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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MRAS-DIAPH3 (FusionGDB2 ID:54823)

Fusion Gene Summary for MRAS-DIAPH3

check button Fusion gene summary
Fusion gene informationFusion gene name: MRAS-DIAPH3
Fusion gene ID: 54823
HgeneTgene
Gene symbol

MRAS

DIAPH3

Gene ID

22808

81624

Gene namemuscle RAS oncogene homologdiaphanous related formin 3
SynonymsM-RAs|NS11|R-RAS3|RRAS3AN|AUNA1|DIA2|DRF3|NSDAN|diap3|mDia2
Cytomap

3q22.3

13q21.2

Type of geneprotein-codingprotein-coding
Descriptionras-related protein M-Rasmuscle and microspikes RASras-related protein R-Ras3protein diaphanous homolog 3diaphanous homolog 3
Modification date2020031320200313
UniProtAcc

O14807

Q9NSV4

Ensembl transtripts involved in fusion geneENST00000289104, ENST00000423968, 
ENST00000474559, ENST00000461114, 
ENST00000464896, 		ENST00000465066, 
ENST00000267215, ENST00000377908, 
ENST00000400319, ENST00000400320, 
ENST00000400324, ENST00000400330, 
Fusion gene scores* DoF score3 X 1 X 3=920 X 18 X 9=3240
# samples 323
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(23/3240*10)=-3.81628804682761
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MRAS [Title/Abstract] AND DIAPH3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMRAS(138091918)-DIAPH3(60348957), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MRAS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DIAPH3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4READTCGA-AG-3601MRASchr3

138091918

+DIAPH3chr13

60348957

-


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Fusion Gene ORF analysis for MRAS-DIAPH3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000289104ENST00000465066MRASchr3

138091918

+DIAPH3chr13

60348957

-
5CDS-5UTRENST00000423968ENST00000465066MRASchr3

138091918

+DIAPH3chr13

60348957

-
5CDS-5UTRENST00000474559ENST00000465066MRASchr3

138091918

+DIAPH3chr13

60348957

-
In-frameENST00000289104ENST00000267215MRASchr3

138091918

+DIAPH3chr13

60348957

-
In-frameENST00000289104ENST00000377908MRASchr3

138091918

+DIAPH3chr13

60348957

-
In-frameENST00000289104ENST00000400319MRASchr3

138091918

+DIAPH3chr13

60348957

-
In-frameENST00000289104ENST00000400320MRASchr3

138091918

+DIAPH3chr13

60348957

-
In-frameENST00000289104ENST00000400324MRASchr3

138091918

+DIAPH3chr13

60348957

-
In-frameENST00000289104ENST00000400330MRASchr3

138091918

+DIAPH3chr13

60348957

-
In-frameENST00000423968ENST00000267215MRASchr3

138091918

+DIAPH3chr13

60348957

-
In-frameENST00000423968ENST00000377908MRASchr3

138091918

+DIAPH3chr13

60348957

-
In-frameENST00000423968ENST00000400319MRASchr3

138091918

+DIAPH3chr13

60348957

-
In-frameENST00000423968ENST00000400320MRASchr3

138091918

+DIAPH3chr13

60348957

-
In-frameENST00000423968ENST00000400324MRASchr3

138091918

+DIAPH3chr13

60348957

-
In-frameENST00000423968ENST00000400330MRASchr3

138091918

+DIAPH3chr13

60348957

-
In-frameENST00000474559ENST00000267215MRASchr3

138091918

+DIAPH3chr13

60348957

-
In-frameENST00000474559ENST00000377908MRASchr3

138091918

+DIAPH3chr13

60348957

-
In-frameENST00000474559ENST00000400319MRASchr3

138091918

+DIAPH3chr13

60348957

-
In-frameENST00000474559ENST00000400320MRASchr3

138091918

+DIAPH3chr13

60348957

-
In-frameENST00000474559ENST00000400324MRASchr3

138091918

+DIAPH3chr13

60348957

-
In-frameENST00000474559ENST00000400330MRASchr3

138091918

+DIAPH3chr13

60348957

-
intron-3CDSENST00000461114ENST00000267215MRASchr3

138091918

+DIAPH3chr13

60348957

-
intron-3CDSENST00000461114ENST00000377908MRASchr3

138091918

+DIAPH3chr13

60348957

-
intron-3CDSENST00000461114ENST00000400319MRASchr3

138091918

+DIAPH3chr13

60348957

-
intron-3CDSENST00000461114ENST00000400320MRASchr3

138091918

+DIAPH3chr13

60348957

-
intron-3CDSENST00000461114ENST00000400324MRASchr3

138091918

+DIAPH3chr13

60348957

-
intron-3CDSENST00000461114ENST00000400330MRASchr3

138091918

+DIAPH3chr13

60348957

-
intron-3CDSENST00000464896ENST00000267215MRASchr3

138091918

+DIAPH3chr13

60348957

-
intron-3CDSENST00000464896ENST00000377908MRASchr3

138091918

+DIAPH3chr13

60348957

-
intron-3CDSENST00000464896ENST00000400319MRASchr3

138091918

+DIAPH3chr13

60348957

-
intron-3CDSENST00000464896ENST00000400320MRASchr3

138091918

+DIAPH3chr13

60348957

-
intron-3CDSENST00000464896ENST00000400324MRASchr3

138091918

+DIAPH3chr13

60348957

-
intron-3CDSENST00000464896ENST00000400330MRASchr3

138091918

+DIAPH3chr13

60348957

-
intron-5UTRENST00000461114ENST00000465066MRASchr3

138091918

+DIAPH3chr13

60348957

-
intron-5UTRENST00000464896ENST00000465066MRASchr3

138091918

+DIAPH3chr13

60348957

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000289104MRASchr3138091918+ENST00000400324DIAPH3chr1360348957-22608406471258203
ENST00000289104MRASchr3138091918+ENST00000400330DIAPH3chr1360348957-22528406471258203
ENST00000289104MRASchr3138091918+ENST00000400319DIAPH3chr1360348957-12598406471258204
ENST00000289104MRASchr3138091918+ENST00000400320DIAPH3chr1360348957-12598406471258204
ENST00000289104MRASchr3138091918+ENST00000377908DIAPH3chr1360348957-12598406471258204
ENST00000289104MRASchr3138091918+ENST00000267215DIAPH3chr1360348957-1126840994554146
ENST00000423968MRASchr3138091918+ENST00000400324DIAPH3chr1360348957-1927507314925203
ENST00000423968MRASchr3138091918+ENST00000400330DIAPH3chr1360348957-1919507314925203
ENST00000423968MRASchr3138091918+ENST00000400319DIAPH3chr1360348957-926507314925204
ENST00000423968MRASchr3138091918+ENST00000400320DIAPH3chr1360348957-926507314925204
ENST00000423968MRASchr3138091918+ENST00000377908DIAPH3chr1360348957-926507314925204
ENST00000423968MRASchr3138091918+ENST00000267215DIAPH3chr1360348957-793507661245138
ENST00000474559MRASchr3138091918+ENST00000400324DIAPH3chr1360348957-1749329136747203
ENST00000474559MRASchr3138091918+ENST00000400330DIAPH3chr1360348957-1741329136747203
ENST00000474559MRASchr3138091918+ENST00000400319DIAPH3chr1360348957-748329136747204
ENST00000474559MRASchr3138091918+ENST00000400320DIAPH3chr1360348957-748329136747204
ENST00000474559MRASchr3138091918+ENST00000377908DIAPH3chr1360348957-748329136747204
ENST00000474559MRASchr3138091918+ENST00000267215DIAPH3chr1360348957-615329136504122

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000289104ENST00000400324MRASchr3138091918+DIAPH3chr1360348957-0.0018505730.9981494
ENST00000289104ENST00000400330MRASchr3138091918+DIAPH3chr1360348957-0.0018310670.99816895
ENST00000289104ENST00000400319MRASchr3138091918+DIAPH3chr1360348957-0.0032068880.9967931
ENST00000289104ENST00000400320MRASchr3138091918+DIAPH3chr1360348957-0.0032068880.9967931
ENST00000289104ENST00000377908MRASchr3138091918+DIAPH3chr1360348957-0.0032068880.9967931
ENST00000289104ENST00000267215MRASchr3138091918+DIAPH3chr1360348957-0.0164114440.9835886
ENST00000423968ENST00000400324MRASchr3138091918+DIAPH3chr1360348957-0.0012735740.9987264
ENST00000423968ENST00000400330MRASchr3138091918+DIAPH3chr1360348957-0.0012941550.99870586
ENST00000423968ENST00000400319MRASchr3138091918+DIAPH3chr1360348957-0.0042886180.99571145
ENST00000423968ENST00000400320MRASchr3138091918+DIAPH3chr1360348957-0.0042886180.99571145
ENST00000423968ENST00000377908MRASchr3138091918+DIAPH3chr1360348957-0.0042886180.99571145
ENST00000423968ENST00000267215MRASchr3138091918+DIAPH3chr1360348957-0.0168568830.98314315
ENST00000474559ENST00000400324MRASchr3138091918+DIAPH3chr1360348957-0.0011865330.9988135
ENST00000474559ENST00000400330MRASchr3138091918+DIAPH3chr1360348957-0.0012304880.99876946
ENST00000474559ENST00000400319MRASchr3138091918+DIAPH3chr1360348957-0.0022927560.99770725
ENST00000474559ENST00000400320MRASchr3138091918+DIAPH3chr1360348957-0.0022927560.99770725
ENST00000474559ENST00000377908MRASchr3138091918+DIAPH3chr1360348957-0.0022927560.99770725
ENST00000474559ENST00000267215MRASchr3138091918+DIAPH3chr1360348957-0.0062700180.99372995

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Fusion Genomic Features for MRAS-DIAPH3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MRAS-DIAPH3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:138091918/chr13:60348957)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MRAS

O14807

DIAPH3

Q9NSV4

FUNCTION: Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway. {ECO:0000269|PubMed:16630891, ECO:0000269|PubMed:28289718}.FUNCTION: Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity. {ECO:0000250|UniProtKB:Q9Z207}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMRASchr3:138091918chr13:60348957ENST00000289104+2642_5064209.0MotifNote=Effector region
HgeneMRASchr3:138091918chr13:60348957ENST00000423968+2642_5064209.0MotifNote=Effector region
HgeneMRASchr3:138091918chr13:60348957ENST00000474559+2642_5064209.0MotifNote=Effector region
HgeneMRASchr3:138091918chr13:60348957ENST00000289104+2620_2764209.0Nucleotide bindingGTP
HgeneMRASchr3:138091918chr13:60348957ENST00000423968+2620_2764209.0Nucleotide bindingGTP
HgeneMRASchr3:138091918chr13:60348957ENST00000474559+2620_2764209.0Nucleotide bindingGTP
TgeneDIAPH3chr3:138091918chr13:60348957ENST0000040031922261013_10569841124.0Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr3:138091918chr13:60348957ENST0000040032022261013_105610081148.0Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr3:138091918chr13:60348957ENST0000026721524271057_108710541113.0DomainDAD
TgeneDIAPH3chr3:138091918chr13:60348957ENST0000037790823271057_108710431183.0DomainDAD
TgeneDIAPH3chr3:138091918chr13:60348957ENST0000040031922261057_10879841124.0DomainDAD
TgeneDIAPH3chr3:138091918chr13:60348957ENST0000040032022261057_108710081148.0DomainDAD
TgeneDIAPH3chr3:138091918chr13:60348957ENST0000040032424281057_108710541194.0DomainDAD
TgeneDIAPH3chr3:138091918chr13:60348957ENST0000026721524271184_119310541113.0MotifNuclear export signal
TgeneDIAPH3chr3:138091918chr13:60348957ENST0000037790823271184_119310431183.0MotifNuclear export signal
TgeneDIAPH3chr3:138091918chr13:60348957ENST0000040031922261184_11939841124.0MotifNuclear export signal
TgeneDIAPH3chr3:138091918chr13:60348957ENST0000040032022261184_119310081148.0MotifNuclear export signal
TgeneDIAPH3chr3:138091918chr13:60348957ENST0000040032424281184_119310541194.0MotifNuclear export signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMRASchr3:138091918chr13:60348957ENST00000289104+26185_19164209.0Compositional biasNote=Poly-Lys
HgeneMRASchr3:138091918chr13:60348957ENST00000423968+26185_19164209.0Compositional biasNote=Poly-Lys
HgeneMRASchr3:138091918chr13:60348957ENST00000464896+15185_1910133.0Compositional biasNote=Poly-Lys
HgeneMRASchr3:138091918chr13:60348957ENST00000474559+26185_19164209.0Compositional biasNote=Poly-Lys
HgeneMRASchr3:138091918chr13:60348957ENST00000464896+1542_500133.0MotifNote=Effector region
HgeneMRASchr3:138091918chr13:60348957ENST00000289104+26126_12964209.0Nucleotide bindingGTP
HgeneMRASchr3:138091918chr13:60348957ENST00000289104+2667_7164209.0Nucleotide bindingGTP
HgeneMRASchr3:138091918chr13:60348957ENST00000423968+26126_12964209.0Nucleotide bindingGTP
HgeneMRASchr3:138091918chr13:60348957ENST00000423968+2667_7164209.0Nucleotide bindingGTP
HgeneMRASchr3:138091918chr13:60348957ENST00000464896+15126_1290133.0Nucleotide bindingGTP
HgeneMRASchr3:138091918chr13:60348957ENST00000464896+1520_270133.0Nucleotide bindingGTP
HgeneMRASchr3:138091918chr13:60348957ENST00000464896+1567_710133.0Nucleotide bindingGTP
HgeneMRASchr3:138091918chr13:60348957ENST00000474559+26126_12964209.0Nucleotide bindingGTP
HgeneMRASchr3:138091918chr13:60348957ENST00000474559+2667_7164209.0Nucleotide bindingGTP
TgeneDIAPH3chr3:138091918chr13:60348957ENST0000026721524271013_105610541113.0Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr3:138091918chr13:60348957ENST000002672152427497_55410541113.0Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr3:138091918chr13:60348957ENST0000037790823271013_105610431183.0Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr3:138091918chr13:60348957ENST000003779082327497_55410431183.0Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr3:138091918chr13:60348957ENST000004003192226497_5549841124.0Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr3:138091918chr13:60348957ENST000004003202226497_55410081148.0Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr3:138091918chr13:60348957ENST0000040032424281013_105610541194.0Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr3:138091918chr13:60348957ENST000004003242428497_55410541194.0Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr3:138091918chr13:60348957ENST000002672152427561_63610541113.0Compositional biasNote=Pro-rich
TgeneDIAPH3chr3:138091918chr13:60348957ENST000003779082327561_63610431183.0Compositional biasNote=Pro-rich
TgeneDIAPH3chr3:138091918chr13:60348957ENST000004003192226561_6369841124.0Compositional biasNote=Pro-rich
TgeneDIAPH3chr3:138091918chr13:60348957ENST000004003202226561_63610081148.0Compositional biasNote=Pro-rich
TgeneDIAPH3chr3:138091918chr13:60348957ENST000004003242428561_63610541194.0Compositional biasNote=Pro-rich
TgeneDIAPH3chr3:138091918chr13:60348957ENST000002672152427114_47610541113.0DomainGBD/FH3
TgeneDIAPH3chr3:138091918chr13:60348957ENST000002672152427561_63110541113.0DomainNote=FH1
TgeneDIAPH3chr3:138091918chr13:60348957ENST000002672152427636_103410541113.0DomainFH2
TgeneDIAPH3chr3:138091918chr13:60348957ENST000003779082327114_47610431183.0DomainGBD/FH3
TgeneDIAPH3chr3:138091918chr13:60348957ENST000003779082327561_63110431183.0DomainNote=FH1
TgeneDIAPH3chr3:138091918chr13:60348957ENST000003779082327636_103410431183.0DomainFH2
TgeneDIAPH3chr3:138091918chr13:60348957ENST000004003192226114_4769841124.0DomainGBD/FH3
TgeneDIAPH3chr3:138091918chr13:60348957ENST000004003192226561_6319841124.0DomainNote=FH1
TgeneDIAPH3chr3:138091918chr13:60348957ENST000004003192226636_10349841124.0DomainFH2
TgeneDIAPH3chr3:138091918chr13:60348957ENST000004003202226114_47610081148.0DomainGBD/FH3
TgeneDIAPH3chr3:138091918chr13:60348957ENST000004003202226561_63110081148.0DomainNote=FH1
TgeneDIAPH3chr3:138091918chr13:60348957ENST000004003202226636_103410081148.0DomainFH2
TgeneDIAPH3chr3:138091918chr13:60348957ENST000004003242428114_47610541194.0DomainGBD/FH3
TgeneDIAPH3chr3:138091918chr13:60348957ENST000004003242428561_63110541194.0DomainNote=FH1
TgeneDIAPH3chr3:138091918chr13:60348957ENST000004003242428636_103410541194.0DomainFH2
TgeneDIAPH3chr3:138091918chr13:60348957ENST00000267215242736_6010541113.0MotifNuclear localization signal
TgeneDIAPH3chr3:138091918chr13:60348957ENST00000377908232736_6010431183.0MotifNuclear localization signal
TgeneDIAPH3chr3:138091918chr13:60348957ENST00000400319222636_609841124.0MotifNuclear localization signal
TgeneDIAPH3chr3:138091918chr13:60348957ENST00000400320222636_6010081148.0MotifNuclear localization signal
TgeneDIAPH3chr3:138091918chr13:60348957ENST00000400324242836_6010541194.0MotifNuclear localization signal


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Fusion Gene Sequence for MRAS-DIAPH3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>54823_54823_1_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000289104_DIAPH3_chr13_60348957_ENST00000267215_length(transcript)=1126nt_BP=840nt
ATTCTCCTGCCTCAGCCTCCCGAGTAGATGAGATCACAGGCACGTGCCGCCATGCCGGGTTGACTTTTGTATTTTTAGTAGAGACGGGGT
TTCACCATGTTGCCTAGGCTGGTCTTGAACTCCTGACCTCAGGCGATTCACCCGCCTCGGCCTCCCAAAGTGTTAGGATTACAGGCGTGA
GCCACCGCGCCCGGCTTGAATTGTACACTTCAAAAGGTGGAATTTTATGGTGTTGAATTATATCTTTATTTTTTTAACGGGGGGAAAATG
ACGCCGCTGGAGAGGAGTTAGCGGAACTGAAACAATGAAATGGTGCGCGAGTGTCGCCTGTCCCCGTCGCATCCATCCCAACGAAGTTTG
GGCCCTGGAACGGTGCACCCAGAAGGCCTGCGGGGAGAGACGCTGGGGCATGATCTGGAAGAAAGACGTCTCAGGATTCGAAGGGAATGC
AGCTAAGGTGGCGGCGGAGGTTCGCCTAGGACTGGGGAGGCGTCCCTAGGCTCAGAAGTTGGCCCGGCCGGAGCGGAGATTTAAAGGTTG
GAGCGCAGAGGCTCTTAAAGAGGCCGAGTCGAATTCCCACTCGGCGTCCACCTTAAAGCCAGCTCCCCGGCACCACGGATCTGACCCGGG
TCTGACCTACGAGAAACATGGCAACCAGCGCCGTCCCCAGTGACAACCTCCCCACATACAAGCTGGTGGTGGTGGGGGATGGGGGTGTGG
GCAAAAGTGCCCTCACCATCCAGTTTTTCCAGAAGATCTTTGTGCCTGACTATGACCCCACCATTGAAGACTCCTACCTGAAACATACGG
AGATTGACAATCAATGGGCCATCTTGGACGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCT
TCCGCGACAGAAGAAAAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTA
ACCATGGTAATAAACCGTATTTATAAATTGCACATTCTTCTTATCTACTTTTATCCTATTGATCTGTGATTTTAGTAGACTGCTGTGAAA

>54823_54823_1_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000289104_DIAPH3_chr13_60348957_ENST00000267215_length(amino acids)=146AA_BP=0
MVTNFQNRPLRHWTETLPNIFWHRCPFSSVAEGSPGLQGLQQIIHHSCLITLVQDGPLIVNLRMFQVGVFNGGVIVRHKDLLEKLDGEGT

--------------------------------------------------------------
>54823_54823_2_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000289104_DIAPH3_chr13_60348957_ENST00000377908_length(transcript)=1259nt_BP=840nt
ATTCTCCTGCCTCAGCCTCCCGAGTAGATGAGATCACAGGCACGTGCCGCCATGCCGGGTTGACTTTTGTATTTTTAGTAGAGACGGGGT
TTCACCATGTTGCCTAGGCTGGTCTTGAACTCCTGACCTCAGGCGATTCACCCGCCTCGGCCTCCCAAAGTGTTAGGATTACAGGCGTGA
GCCACCGCGCCCGGCTTGAATTGTACACTTCAAAAGGTGGAATTTTATGGTGTTGAATTATATCTTTATTTTTTTAACGGGGGGAAAATG
ACGCCGCTGGAGAGGAGTTAGCGGAACTGAAACAATGAAATGGTGCGCGAGTGTCGCCTGTCCCCGTCGCATCCATCCCAACGAAGTTTG
GGCCCTGGAACGGTGCACCCAGAAGGCCTGCGGGGAGAGACGCTGGGGCATGATCTGGAAGAAAGACGTCTCAGGATTCGAAGGGAATGC
AGCTAAGGTGGCGGCGGAGGTTCGCCTAGGACTGGGGAGGCGTCCCTAGGCTCAGAAGTTGGCCCGGCCGGAGCGGAGATTTAAAGGTTG
GAGCGCAGAGGCTCTTAAAGAGGCCGAGTCGAATTCCCACTCGGCGTCCACCTTAAAGCCAGCTCCCCGGCACCACGGATCTGACCCGGG
TCTGACCTACGAGAAACATGGCAACCAGCGCCGTCCCCAGTGACAACCTCCCCACATACAAGCTGGTGGTGGTGGGGGATGGGGGTGTGG
GCAAAAGTGCCCTCACCATCCAGTTTTTCCAGAAGATCTTTGTGCCTGACTATGACCCCACCATTGAAGACTCCTACCTGAAACATACGG
AGATTGACAATCAATGGGCCATCTTGGACGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCT
TCCGCGACAGAAGAAAAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTA
ACCATGAAAATCAGAAAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGG
AGCTTAATTATAATCTAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAA

>54823_54823_2_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000289104_DIAPH3_chr13_60348957_ENST00000377908_length(amino acids)=204AA_BP=64
MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDEGDETGVMDNLLEALQSGAAFRDRRK
RTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVESNRKKETEL

--------------------------------------------------------------
>54823_54823_3_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000289104_DIAPH3_chr13_60348957_ENST00000400319_length(transcript)=1259nt_BP=840nt
ATTCTCCTGCCTCAGCCTCCCGAGTAGATGAGATCACAGGCACGTGCCGCCATGCCGGGTTGACTTTTGTATTTTTAGTAGAGACGGGGT
TTCACCATGTTGCCTAGGCTGGTCTTGAACTCCTGACCTCAGGCGATTCACCCGCCTCGGCCTCCCAAAGTGTTAGGATTACAGGCGTGA
GCCACCGCGCCCGGCTTGAATTGTACACTTCAAAAGGTGGAATTTTATGGTGTTGAATTATATCTTTATTTTTTTAACGGGGGGAAAATG
ACGCCGCTGGAGAGGAGTTAGCGGAACTGAAACAATGAAATGGTGCGCGAGTGTCGCCTGTCCCCGTCGCATCCATCCCAACGAAGTTTG
GGCCCTGGAACGGTGCACCCAGAAGGCCTGCGGGGAGAGACGCTGGGGCATGATCTGGAAGAAAGACGTCTCAGGATTCGAAGGGAATGC
AGCTAAGGTGGCGGCGGAGGTTCGCCTAGGACTGGGGAGGCGTCCCTAGGCTCAGAAGTTGGCCCGGCCGGAGCGGAGATTTAAAGGTTG
GAGCGCAGAGGCTCTTAAAGAGGCCGAGTCGAATTCCCACTCGGCGTCCACCTTAAAGCCAGCTCCCCGGCACCACGGATCTGACCCGGG
TCTGACCTACGAGAAACATGGCAACCAGCGCCGTCCCCAGTGACAACCTCCCCACATACAAGCTGGTGGTGGTGGGGGATGGGGGTGTGG
GCAAAAGTGCCCTCACCATCCAGTTTTTCCAGAAGATCTTTGTGCCTGACTATGACCCCACCATTGAAGACTCCTACCTGAAACATACGG
AGATTGACAATCAATGGGCCATCTTGGACGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCT
TCCGCGACAGAAGAAAAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTA
ACCATGAAAATCAGAAAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGG
AGCTTAATTATAATCTAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAA

>54823_54823_3_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000289104_DIAPH3_chr13_60348957_ENST00000400319_length(amino acids)=204AA_BP=64
MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDEGDETGVMDNLLEALQSGAAFRDRRK
RTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVESNRKKETEL

--------------------------------------------------------------
>54823_54823_4_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000289104_DIAPH3_chr13_60348957_ENST00000400320_length(transcript)=1259nt_BP=840nt
ATTCTCCTGCCTCAGCCTCCCGAGTAGATGAGATCACAGGCACGTGCCGCCATGCCGGGTTGACTTTTGTATTTTTAGTAGAGACGGGGT
TTCACCATGTTGCCTAGGCTGGTCTTGAACTCCTGACCTCAGGCGATTCACCCGCCTCGGCCTCCCAAAGTGTTAGGATTACAGGCGTGA
GCCACCGCGCCCGGCTTGAATTGTACACTTCAAAAGGTGGAATTTTATGGTGTTGAATTATATCTTTATTTTTTTAACGGGGGGAAAATG
ACGCCGCTGGAGAGGAGTTAGCGGAACTGAAACAATGAAATGGTGCGCGAGTGTCGCCTGTCCCCGTCGCATCCATCCCAACGAAGTTTG
GGCCCTGGAACGGTGCACCCAGAAGGCCTGCGGGGAGAGACGCTGGGGCATGATCTGGAAGAAAGACGTCTCAGGATTCGAAGGGAATGC
AGCTAAGGTGGCGGCGGAGGTTCGCCTAGGACTGGGGAGGCGTCCCTAGGCTCAGAAGTTGGCCCGGCCGGAGCGGAGATTTAAAGGTTG
GAGCGCAGAGGCTCTTAAAGAGGCCGAGTCGAATTCCCACTCGGCGTCCACCTTAAAGCCAGCTCCCCGGCACCACGGATCTGACCCGGG
TCTGACCTACGAGAAACATGGCAACCAGCGCCGTCCCCAGTGACAACCTCCCCACATACAAGCTGGTGGTGGTGGGGGATGGGGGTGTGG
GCAAAAGTGCCCTCACCATCCAGTTTTTCCAGAAGATCTTTGTGCCTGACTATGACCCCACCATTGAAGACTCCTACCTGAAACATACGG
AGATTGACAATCAATGGGCCATCTTGGACGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCT
TCCGCGACAGAAGAAAAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTA
ACCATGAAAATCAGAAAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGG
AGCTTAATTATAATCTAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAA

>54823_54823_4_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000289104_DIAPH3_chr13_60348957_ENST00000400320_length(amino acids)=204AA_BP=64
MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDEGDETGVMDNLLEALQSGAAFRDRRK
RTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVESNRKKETEL

--------------------------------------------------------------
>54823_54823_5_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000289104_DIAPH3_chr13_60348957_ENST00000400324_length(transcript)=2260nt_BP=840nt
ATTCTCCTGCCTCAGCCTCCCGAGTAGATGAGATCACAGGCACGTGCCGCCATGCCGGGTTGACTTTTGTATTTTTAGTAGAGACGGGGT
TTCACCATGTTGCCTAGGCTGGTCTTGAACTCCTGACCTCAGGCGATTCACCCGCCTCGGCCTCCCAAAGTGTTAGGATTACAGGCGTGA
GCCACCGCGCCCGGCTTGAATTGTACACTTCAAAAGGTGGAATTTTATGGTGTTGAATTATATCTTTATTTTTTTAACGGGGGGAAAATG
ACGCCGCTGGAGAGGAGTTAGCGGAACTGAAACAATGAAATGGTGCGCGAGTGTCGCCTGTCCCCGTCGCATCCATCCCAACGAAGTTTG
GGCCCTGGAACGGTGCACCCAGAAGGCCTGCGGGGAGAGACGCTGGGGCATGATCTGGAAGAAAGACGTCTCAGGATTCGAAGGGAATGC
AGCTAAGGTGGCGGCGGAGGTTCGCCTAGGACTGGGGAGGCGTCCCTAGGCTCAGAAGTTGGCCCGGCCGGAGCGGAGATTTAAAGGTTG
GAGCGCAGAGGCTCTTAAAGAGGCCGAGTCGAATTCCCACTCGGCGTCCACCTTAAAGCCAGCTCCCCGGCACCACGGATCTGACCCGGG
TCTGACCTACGAGAAACATGGCAACCAGCGCCGTCCCCAGTGACAACCTCCCCACATACAAGCTGGTGGTGGTGGGGGATGGGGGTGTGG
GCAAAAGTGCCCTCACCATCCAGTTTTTCCAGAAGATCTTTGTGCCTGACTATGACCCCACCATTGAAGACTCCTACCTGAAACATACGG
AGATTGACAATCAATGGGCCATCTTGGACGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCT
TCCGCGACAGAAGAAAAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTA
ACCATGAAAATCAGAAAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGG
AGCTTAATTATAATCTAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAA
AAAAGGAAACGGAACTTCTTGGCTCTTTTTCTAAAAATGAATCAGTTCCCGAAGTTGAAGCCCTGCTGGCAAGATTACGAGCTTTATAAG
TTAAACTGGTTTTTAAAAAAAATGATTAAGCCAAATATAAAGCCATGCTCTAAACTATAACACTTGAAAAAATTGCTTTTATGTAAGTGA
CTTTATATAGTTTTAAATTATGATATATATTAGAAAAATAAAGCTAAATATATGATTGCAATGCTTTTTCTATGTACTGGAGGTTTTGGT
TTATTCAAGATTGTACCGGGCTTTAATCCTTTTTTTTTTTTTTTTGTCTCCTGGTATTCCTCAGTTCTTTATTTGGTGGTTAAATTATAC
ATATTGCTTTAGAGAGCAGGTAGGTGGCCATGTGTTCAGCAGTGTGTCCTTAAGAAAATACCATCTTTCTAAGCCACTGGAATTTTTACT
TTACTATTTTTAACATTAATGGATGTCAGGTCATCAACCTCAAGTCTTTACATATCCATGTATATTCCATATATATTGTTTATATAGGCC
CAAGTTTCTCCTTAATTGGGATCTATATACTACCAGCACAACATCAAAAACATGTAATTGAATACATCAGAGCTATATATGTAAGGAAAT
GACTGGTGACCCCATTATCATCATTGTTGAATTCATGTTAAGTAGACCCTCTAGGGGACCATAAGGCAATTGAGCACATAACGAAAAATG
ATGCAATAAGAATGTATGCACTCTCTTTGCCAAATGCATGTGCTTTTGTGTAACGTGGATGTAAACAGAATTGCAGTGCTGCCGAAATTC
TTGATCTTGGCTAAGAGAGTATTTTTCCCCTTGTAATTATGACTCTGAGATAAAATTGCCATTTTGAAATTTCCAAAGTAACAACTTTTT
TTATTTTATGAATAAACTTGGGATTGCAATTTCTCTGATCTGACAATCAATAACTTTAACAAAGATCTAAATAAGTGTTTCAAGGAAAGT
TTTCCTAAGCAAATGTAATATTACCTCATTTGGGCATCATTACTCTGTTAATTCTATATCAAAGGAAATAAACTTGCTACTTGCACTAAA

>54823_54823_5_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000289104_DIAPH3_chr13_60348957_ENST00000400324_length(amino acids)=203AA_BP=64
MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDEGDETGVMDNLLEALQSGAAFRDRRK
RTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVESNRKKETEL

--------------------------------------------------------------
>54823_54823_6_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000289104_DIAPH3_chr13_60348957_ENST00000400330_length(transcript)=2252nt_BP=840nt
ATTCTCCTGCCTCAGCCTCCCGAGTAGATGAGATCACAGGCACGTGCCGCCATGCCGGGTTGACTTTTGTATTTTTAGTAGAGACGGGGT
TTCACCATGTTGCCTAGGCTGGTCTTGAACTCCTGACCTCAGGCGATTCACCCGCCTCGGCCTCCCAAAGTGTTAGGATTACAGGCGTGA
GCCACCGCGCCCGGCTTGAATTGTACACTTCAAAAGGTGGAATTTTATGGTGTTGAATTATATCTTTATTTTTTTAACGGGGGGAAAATG
ACGCCGCTGGAGAGGAGTTAGCGGAACTGAAACAATGAAATGGTGCGCGAGTGTCGCCTGTCCCCGTCGCATCCATCCCAACGAAGTTTG
GGCCCTGGAACGGTGCACCCAGAAGGCCTGCGGGGAGAGACGCTGGGGCATGATCTGGAAGAAAGACGTCTCAGGATTCGAAGGGAATGC
AGCTAAGGTGGCGGCGGAGGTTCGCCTAGGACTGGGGAGGCGTCCCTAGGCTCAGAAGTTGGCCCGGCCGGAGCGGAGATTTAAAGGTTG
GAGCGCAGAGGCTCTTAAAGAGGCCGAGTCGAATTCCCACTCGGCGTCCACCTTAAAGCCAGCTCCCCGGCACCACGGATCTGACCCGGG
TCTGACCTACGAGAAACATGGCAACCAGCGCCGTCCCCAGTGACAACCTCCCCACATACAAGCTGGTGGTGGTGGGGGATGGGGGTGTGG
GCAAAAGTGCCCTCACCATCCAGTTTTTCCAGAAGATCTTTGTGCCTGACTATGACCCCACCATTGAAGACTCCTACCTGAAACATACGG
AGATTGACAATCAATGGGCCATCTTGGACGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCT
TCCGCGACAGAAGAAAAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTA
ACCATGAAAATCAGAAAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGG
AGCTTAATTATAATCTAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAA
AAAAGGAAACGGAACTTCTTGGCTCTTTTTCTAAAAATGAATCAGTTCCCGAAGTTGAAGCCCTGCTGGCAAGATTACGAGCTTTATAAG
TTAAACTGGTTTTTAAAAAAAATGATTAAGCCAAATATAAAGCCATGCTCTAAACTATAACACTTGAAAAAATTGCTTTTATGTAAGTGA
CTTTATATAGTTTTAAATTATGATATATATTAGAAAAATAAAGCTAAATATATGATTGCAATGCTTTTTCTATGTACTGGAGGTTTTGGT
TTATTCAAGATTGTACCGGGCTTTAATCCTTTTTTTTTTTTTTTTGTCTCCTGGTATTCCTCAGTTCTTTATTTGGTGGTTAAATTATAC
ATATTGCTTTAGAGAGCAGGTAGGTGGCCATGTGTTCAGCAGTGTGTCCTTAAGAAAATACCATCTTTCTAAGCCACTGGAATTTTTACT
TTACTATTTTTAACATTAATGGATGTCAGGTCATCAACCTCAAGTCTTTACATATCCATGTATATTCCATATATATTGTTTATATAGGCC
CAAGTTTCTCCTTAATTGGGATCTATATACTACCAGCACAACATCAAAAACATGTAATTGAATACATCAGAGCTATATATGTAAGGAAAT
GACTGGTGACCCCATTATCATCATTGTTGAATTCATGTTAAGTAGACCCTCTAGGGGACCATAAGGCAATTGAGCACATAACGAAAAATG
ATGCAATAAGAATGTATGCACTCTCTTTGCCAAATGCATGTGCTTTTGTGTAACGTGGATGTAAACAGAATTGCAGTGCTGCCGAAATTC
TTGATCTTGGCTAAGAGAGTATTTTTCCCCTTGTAATTATGACTCTGAGATAAAATTGCCATTTTGAAATTTCCAAAGTAACAACTTTTT
TTATTTTATGAATAAACTTGGGATTGCAATTTCTCTGATCTGACAATCAATAACTTTAACAAAGATCTAAATAAGTGTTTCAAGGAAAGT
TTTCCTAAGCAAATGTAATATTACCTCATTTGGGCATCATTACTCTGTTAATTCTATATCAAAGGAAATAAACTTGCTACTTGCACTAAA

>54823_54823_6_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000289104_DIAPH3_chr13_60348957_ENST00000400330_length(amino acids)=203AA_BP=64
MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDEGDETGVMDNLLEALQSGAAFRDRRK
RTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVESNRKKETEL

--------------------------------------------------------------
>54823_54823_7_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000423968_DIAPH3_chr13_60348957_ENST00000267215_length(transcript)=793nt_BP=507nt
AGGGTCGAGGCACCCGGCCCGGGCTCCCCACTGGCGCGCCCGCAGCGGCGCTCTATTTTTAGCAGGCGCTGTGGCAATATAAGGAATGCG
CGGCGCGCTAGGCGCTCGGGGCGCACGCTGGCGGCGCGGTCGCTTTAAGGAGGCGCCGGGGCGGGGACGGACCGGAGTGGCCGGCTGGCG
GGGAGCCGTCAGTCCGGCGGCCGCGGGGCCCGGCGGGCGCGACGCTGCCTCCTCACCGGCGCAGGCTAGGAGGGGGCGGCCTGAGTGCCG
TAGCCGAGCCGGGGCTGGAGCGCGCGGTCTGACCTACGAGAAACATGGCAACCAGCGCCGTCCCCAGTGACAACCTCCCCACATACAAGC
TGGTGGTGGTGGGGGATGGGGGTGTGGGCAAAAGTGCCCTCACCATCCAGTTTTTCCAGAAGATCTTTGTGCCTGACTATGACCCCACCA
TTGAAGACTCCTACCTGAAACATACGGAGATTGACAATCAATGGGCCATCTTGGACGAGGGTGATGAGACAGGAGTGATGGATAATCTGC
TGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAAAAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGT
CTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGGTAATAAACCGTATTTATAAATTGCACATTCTTCTTATCTACTTTTATCCTATTGAT

>54823_54823_7_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000423968_DIAPH3_chr13_60348957_ENST00000267215_length(amino acids)=138AA_BP=0
MVTNFQNRPLRHWTETLPNIFWHRCPFSSVAEGSPGLQGLQQIIHHSCLITLVQDGPLIVNLRMFQVGVFNGGVIVRHKDLLEKLDGEGT

--------------------------------------------------------------
>54823_54823_8_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000423968_DIAPH3_chr13_60348957_ENST00000377908_length(transcript)=926nt_BP=507nt
AGGGTCGAGGCACCCGGCCCGGGCTCCCCACTGGCGCGCCCGCAGCGGCGCTCTATTTTTAGCAGGCGCTGTGGCAATATAAGGAATGCG
CGGCGCGCTAGGCGCTCGGGGCGCACGCTGGCGGCGCGGTCGCTTTAAGGAGGCGCCGGGGCGGGGACGGACCGGAGTGGCCGGCTGGCG
GGGAGCCGTCAGTCCGGCGGCCGCGGGGCCCGGCGGGCGCGACGCTGCCTCCTCACCGGCGCAGGCTAGGAGGGGGCGGCCTGAGTGCCG
TAGCCGAGCCGGGGCTGGAGCGCGCGGTCTGACCTACGAGAAACATGGCAACCAGCGCCGTCCCCAGTGACAACCTCCCCACATACAAGC
TGGTGGTGGTGGGGGATGGGGGTGTGGGCAAAAGTGCCCTCACCATCCAGTTTTTCCAGAAGATCTTTGTGCCTGACTATGACCCCACCA
TTGAAGACTCCTACCTGAAACATACGGAGATTGACAATCAATGGGCCATCTTGGACGAGGGTGATGAGACAGGAGTGATGGATAATCTGC
TGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAAAAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGT
CTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGAAAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCA
ACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATCTAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGG
AAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAACTTCTTGGCTCTTTTTCTAAAAATGAATCAGTTCCCGAAGTTGAAGCCC

>54823_54823_8_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000423968_DIAPH3_chr13_60348957_ENST00000377908_length(amino acids)=204AA_BP=64
MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDEGDETGVMDNLLEALQSGAAFRDRRK
RTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVESNRKKETEL

--------------------------------------------------------------
>54823_54823_9_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000423968_DIAPH3_chr13_60348957_ENST00000400319_length(transcript)=926nt_BP=507nt
AGGGTCGAGGCACCCGGCCCGGGCTCCCCACTGGCGCGCCCGCAGCGGCGCTCTATTTTTAGCAGGCGCTGTGGCAATATAAGGAATGCG
CGGCGCGCTAGGCGCTCGGGGCGCACGCTGGCGGCGCGGTCGCTTTAAGGAGGCGCCGGGGCGGGGACGGACCGGAGTGGCCGGCTGGCG
GGGAGCCGTCAGTCCGGCGGCCGCGGGGCCCGGCGGGCGCGACGCTGCCTCCTCACCGGCGCAGGCTAGGAGGGGGCGGCCTGAGTGCCG
TAGCCGAGCCGGGGCTGGAGCGCGCGGTCTGACCTACGAGAAACATGGCAACCAGCGCCGTCCCCAGTGACAACCTCCCCACATACAAGC
TGGTGGTGGTGGGGGATGGGGGTGTGGGCAAAAGTGCCCTCACCATCCAGTTTTTCCAGAAGATCTTTGTGCCTGACTATGACCCCACCA
TTGAAGACTCCTACCTGAAACATACGGAGATTGACAATCAATGGGCCATCTTGGACGAGGGTGATGAGACAGGAGTGATGGATAATCTGC
TGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAAAAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGT
CTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGAAAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCA
ACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATCTAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGG
AAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAACTTCTTGGCTCTTTTTCTAAAAATGAATCAGTTCCCGAAGTTGAAGCCC

>54823_54823_9_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000423968_DIAPH3_chr13_60348957_ENST00000400319_length(amino acids)=204AA_BP=64
MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDEGDETGVMDNLLEALQSGAAFRDRRK
RTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVESNRKKETEL

--------------------------------------------------------------
>54823_54823_10_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000423968_DIAPH3_chr13_60348957_ENST00000400320_length(transcript)=926nt_BP=507nt
AGGGTCGAGGCACCCGGCCCGGGCTCCCCACTGGCGCGCCCGCAGCGGCGCTCTATTTTTAGCAGGCGCTGTGGCAATATAAGGAATGCG
CGGCGCGCTAGGCGCTCGGGGCGCACGCTGGCGGCGCGGTCGCTTTAAGGAGGCGCCGGGGCGGGGACGGACCGGAGTGGCCGGCTGGCG
GGGAGCCGTCAGTCCGGCGGCCGCGGGGCCCGGCGGGCGCGACGCTGCCTCCTCACCGGCGCAGGCTAGGAGGGGGCGGCCTGAGTGCCG
TAGCCGAGCCGGGGCTGGAGCGCGCGGTCTGACCTACGAGAAACATGGCAACCAGCGCCGTCCCCAGTGACAACCTCCCCACATACAAGC
TGGTGGTGGTGGGGGATGGGGGTGTGGGCAAAAGTGCCCTCACCATCCAGTTTTTCCAGAAGATCTTTGTGCCTGACTATGACCCCACCA
TTGAAGACTCCTACCTGAAACATACGGAGATTGACAATCAATGGGCCATCTTGGACGAGGGTGATGAGACAGGAGTGATGGATAATCTGC
TGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAAAAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGT
CTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGAAAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCA
ACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATCTAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGG
AAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAACTTCTTGGCTCTTTTTCTAAAAATGAATCAGTTCCCGAAGTTGAAGCCC

>54823_54823_10_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000423968_DIAPH3_chr13_60348957_ENST00000400320_length(amino acids)=204AA_BP=64
MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDEGDETGVMDNLLEALQSGAAFRDRRK
RTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVESNRKKETEL

--------------------------------------------------------------
>54823_54823_11_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000423968_DIAPH3_chr13_60348957_ENST00000400324_length(transcript)=1927nt_BP=507nt
AGGGTCGAGGCACCCGGCCCGGGCTCCCCACTGGCGCGCCCGCAGCGGCGCTCTATTTTTAGCAGGCGCTGTGGCAATATAAGGAATGCG
CGGCGCGCTAGGCGCTCGGGGCGCACGCTGGCGGCGCGGTCGCTTTAAGGAGGCGCCGGGGCGGGGACGGACCGGAGTGGCCGGCTGGCG
GGGAGCCGTCAGTCCGGCGGCCGCGGGGCCCGGCGGGCGCGACGCTGCCTCCTCACCGGCGCAGGCTAGGAGGGGGCGGCCTGAGTGCCG
TAGCCGAGCCGGGGCTGGAGCGCGCGGTCTGACCTACGAGAAACATGGCAACCAGCGCCGTCCCCAGTGACAACCTCCCCACATACAAGC
TGGTGGTGGTGGGGGATGGGGGTGTGGGCAAAAGTGCCCTCACCATCCAGTTTTTCCAGAAGATCTTTGTGCCTGACTATGACCCCACCA
TTGAAGACTCCTACCTGAAACATACGGAGATTGACAATCAATGGGCCATCTTGGACGAGGGTGATGAGACAGGAGTGATGGATAATCTGC
TGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAAAAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGT
CTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGAAAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCA
ACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATCTAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGG
AAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAACTTCTTGGCTCTTTTTCTAAAAATGAATCAGTTCCCGAAGTTGAAGCCC
TGCTGGCAAGATTACGAGCTTTATAAGTTAAACTGGTTTTTAAAAAAAATGATTAAGCCAAATATAAAGCCATGCTCTAAACTATAACAC
TTGAAAAAATTGCTTTTATGTAAGTGACTTTATATAGTTTTAAATTATGATATATATTAGAAAAATAAAGCTAAATATATGATTGCAATG
CTTTTTCTATGTACTGGAGGTTTTGGTTTATTCAAGATTGTACCGGGCTTTAATCCTTTTTTTTTTTTTTTTGTCTCCTGGTATTCCTCA
GTTCTTTATTTGGTGGTTAAATTATACATATTGCTTTAGAGAGCAGGTAGGTGGCCATGTGTTCAGCAGTGTGTCCTTAAGAAAATACCA
TCTTTCTAAGCCACTGGAATTTTTACTTTACTATTTTTAACATTAATGGATGTCAGGTCATCAACCTCAAGTCTTTACATATCCATGTAT
ATTCCATATATATTGTTTATATAGGCCCAAGTTTCTCCTTAATTGGGATCTATATACTACCAGCACAACATCAAAAACATGTAATTGAAT
ACATCAGAGCTATATATGTAAGGAAATGACTGGTGACCCCATTATCATCATTGTTGAATTCATGTTAAGTAGACCCTCTAGGGGACCATA
AGGCAATTGAGCACATAACGAAAAATGATGCAATAAGAATGTATGCACTCTCTTTGCCAAATGCATGTGCTTTTGTGTAACGTGGATGTA
AACAGAATTGCAGTGCTGCCGAAATTCTTGATCTTGGCTAAGAGAGTATTTTTCCCCTTGTAATTATGACTCTGAGATAAAATTGCCATT
TTGAAATTTCCAAAGTAACAACTTTTTTTATTTTATGAATAAACTTGGGATTGCAATTTCTCTGATCTGACAATCAATAACTTTAACAAA
GATCTAAATAAGTGTTTCAAGGAAAGTTTTCCTAAGCAAATGTAATATTACCTCATTTGGGCATCATTACTCTGTTAATTCTATATCAAA

>54823_54823_11_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000423968_DIAPH3_chr13_60348957_ENST00000400324_length(amino acids)=203AA_BP=64
MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDEGDETGVMDNLLEALQSGAAFRDRRK
RTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVESNRKKETEL

--------------------------------------------------------------
>54823_54823_12_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000423968_DIAPH3_chr13_60348957_ENST00000400330_length(transcript)=1919nt_BP=507nt
AGGGTCGAGGCACCCGGCCCGGGCTCCCCACTGGCGCGCCCGCAGCGGCGCTCTATTTTTAGCAGGCGCTGTGGCAATATAAGGAATGCG
CGGCGCGCTAGGCGCTCGGGGCGCACGCTGGCGGCGCGGTCGCTTTAAGGAGGCGCCGGGGCGGGGACGGACCGGAGTGGCCGGCTGGCG
GGGAGCCGTCAGTCCGGCGGCCGCGGGGCCCGGCGGGCGCGACGCTGCCTCCTCACCGGCGCAGGCTAGGAGGGGGCGGCCTGAGTGCCG
TAGCCGAGCCGGGGCTGGAGCGCGCGGTCTGACCTACGAGAAACATGGCAACCAGCGCCGTCCCCAGTGACAACCTCCCCACATACAAGC
TGGTGGTGGTGGGGGATGGGGGTGTGGGCAAAAGTGCCCTCACCATCCAGTTTTTCCAGAAGATCTTTGTGCCTGACTATGACCCCACCA
TTGAAGACTCCTACCTGAAACATACGGAGATTGACAATCAATGGGCCATCTTGGACGAGGGTGATGAGACAGGAGTGATGGATAATCTGC
TGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAAAAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGT
CTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGAAAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCA
ACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATCTAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGG
AAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAACTTCTTGGCTCTTTTTCTAAAAATGAATCAGTTCCCGAAGTTGAAGCCC
TGCTGGCAAGATTACGAGCTTTATAAGTTAAACTGGTTTTTAAAAAAAATGATTAAGCCAAATATAAAGCCATGCTCTAAACTATAACAC
TTGAAAAAATTGCTTTTATGTAAGTGACTTTATATAGTTTTAAATTATGATATATATTAGAAAAATAAAGCTAAATATATGATTGCAATG
CTTTTTCTATGTACTGGAGGTTTTGGTTTATTCAAGATTGTACCGGGCTTTAATCCTTTTTTTTTTTTTTTTGTCTCCTGGTATTCCTCA
GTTCTTTATTTGGTGGTTAAATTATACATATTGCTTTAGAGAGCAGGTAGGTGGCCATGTGTTCAGCAGTGTGTCCTTAAGAAAATACCA
TCTTTCTAAGCCACTGGAATTTTTACTTTACTATTTTTAACATTAATGGATGTCAGGTCATCAACCTCAAGTCTTTACATATCCATGTAT
ATTCCATATATATTGTTTATATAGGCCCAAGTTTCTCCTTAATTGGGATCTATATACTACCAGCACAACATCAAAAACATGTAATTGAAT
ACATCAGAGCTATATATGTAAGGAAATGACTGGTGACCCCATTATCATCATTGTTGAATTCATGTTAAGTAGACCCTCTAGGGGACCATA
AGGCAATTGAGCACATAACGAAAAATGATGCAATAAGAATGTATGCACTCTCTTTGCCAAATGCATGTGCTTTTGTGTAACGTGGATGTA
AACAGAATTGCAGTGCTGCCGAAATTCTTGATCTTGGCTAAGAGAGTATTTTTCCCCTTGTAATTATGACTCTGAGATAAAATTGCCATT
TTGAAATTTCCAAAGTAACAACTTTTTTTATTTTATGAATAAACTTGGGATTGCAATTTCTCTGATCTGACAATCAATAACTTTAACAAA
GATCTAAATAAGTGTTTCAAGGAAAGTTTTCCTAAGCAAATGTAATATTACCTCATTTGGGCATCATTACTCTGTTAATTCTATATCAAA

>54823_54823_12_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000423968_DIAPH3_chr13_60348957_ENST00000400330_length(amino acids)=203AA_BP=64
MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDEGDETGVMDNLLEALQSGAAFRDRRK
RTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVESNRKKETEL

--------------------------------------------------------------
>54823_54823_13_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000474559_DIAPH3_chr13_60348957_ENST00000267215_length(transcript)=615nt_BP=329nt
GCTGTGGTCACAACTAGGGCCTGGGCTCATGCATTGAACTGATCTGGCTGAGGCATCAGACACGGTGCCAGTCCTGCCCTGCGGGGAAGA
CAAGAGCACAAAGTGACAAGCCAGTGTGGTCTGACCTACGAGAAACATGGCAACCAGCGCCGTCCCCAGTGACAACCTCCCCACATACAA
GCTGGTGGTGGTGGGGGATGGGGGTGTGGGCAAAAGTGCCCTCACCATCCAGTTTTTCCAGAAGATCTTTGTGCCTGACTATGACCCCAC
CATTGAAGACTCCTACCTGAAACATACGGAGATTGACAATCAATGGGCCATCTTGGACGAGGGTGATGAGACAGGAGTGATGGATAATCT
GCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAAAAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAAT
GTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGGTAATAAACCGTATTTATAAATTGCACATTCTTCTTATCTACTTTTATCCTATTG

>54823_54823_13_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000474559_DIAPH3_chr13_60348957_ENST00000267215_length(amino acids)=122AA_BP=64
MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDEGDETGVMDNLLEALQSGAAFRDRRK

--------------------------------------------------------------
>54823_54823_14_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000474559_DIAPH3_chr13_60348957_ENST00000377908_length(transcript)=748nt_BP=329nt
GCTGTGGTCACAACTAGGGCCTGGGCTCATGCATTGAACTGATCTGGCTGAGGCATCAGACACGGTGCCAGTCCTGCCCTGCGGGGAAGA
CAAGAGCACAAAGTGACAAGCCAGTGTGGTCTGACCTACGAGAAACATGGCAACCAGCGCCGTCCCCAGTGACAACCTCCCCACATACAA
GCTGGTGGTGGTGGGGGATGGGGGTGTGGGCAAAAGTGCCCTCACCATCCAGTTTTTCCAGAAGATCTTTGTGCCTGACTATGACCCCAC
CATTGAAGACTCCTACCTGAAACATACGGAGATTGACAATCAATGGGCCATCTTGGACGAGGGTGATGAGACAGGAGTGATGGATAATCT
GCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAAAAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAAT
GTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGAAAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTG
CAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATCTAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAA
GGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAACTTCTTGGCTCTTTTTCTAAAAATGAATCAGTTCCCGAAGTTGAAGC

>54823_54823_14_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000474559_DIAPH3_chr13_60348957_ENST00000377908_length(amino acids)=204AA_BP=64
MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDEGDETGVMDNLLEALQSGAAFRDRRK
RTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVESNRKKETEL

--------------------------------------------------------------
>54823_54823_15_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000474559_DIAPH3_chr13_60348957_ENST00000400319_length(transcript)=748nt_BP=329nt
GCTGTGGTCACAACTAGGGCCTGGGCTCATGCATTGAACTGATCTGGCTGAGGCATCAGACACGGTGCCAGTCCTGCCCTGCGGGGAAGA
CAAGAGCACAAAGTGACAAGCCAGTGTGGTCTGACCTACGAGAAACATGGCAACCAGCGCCGTCCCCAGTGACAACCTCCCCACATACAA
GCTGGTGGTGGTGGGGGATGGGGGTGTGGGCAAAAGTGCCCTCACCATCCAGTTTTTCCAGAAGATCTTTGTGCCTGACTATGACCCCAC
CATTGAAGACTCCTACCTGAAACATACGGAGATTGACAATCAATGGGCCATCTTGGACGAGGGTGATGAGACAGGAGTGATGGATAATCT
GCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAAAAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAAT
GTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGAAAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTG
CAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATCTAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAA
GGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAACTTCTTGGCTCTTTTTCTAAAAATGAATCAGTTCCCGAAGTTGAAGC

>54823_54823_15_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000474559_DIAPH3_chr13_60348957_ENST00000400319_length(amino acids)=204AA_BP=64
MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDEGDETGVMDNLLEALQSGAAFRDRRK
RTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVESNRKKETEL

--------------------------------------------------------------
>54823_54823_16_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000474559_DIAPH3_chr13_60348957_ENST00000400320_length(transcript)=748nt_BP=329nt
GCTGTGGTCACAACTAGGGCCTGGGCTCATGCATTGAACTGATCTGGCTGAGGCATCAGACACGGTGCCAGTCCTGCCCTGCGGGGAAGA
CAAGAGCACAAAGTGACAAGCCAGTGTGGTCTGACCTACGAGAAACATGGCAACCAGCGCCGTCCCCAGTGACAACCTCCCCACATACAA
GCTGGTGGTGGTGGGGGATGGGGGTGTGGGCAAAAGTGCCCTCACCATCCAGTTTTTCCAGAAGATCTTTGTGCCTGACTATGACCCCAC
CATTGAAGACTCCTACCTGAAACATACGGAGATTGACAATCAATGGGCCATCTTGGACGAGGGTGATGAGACAGGAGTGATGGATAATCT
GCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAAAAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAAT
GTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGAAAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTG
CAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATCTAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAA
GGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAACTTCTTGGCTCTTTTTCTAAAAATGAATCAGTTCCCGAAGTTGAAGC

>54823_54823_16_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000474559_DIAPH3_chr13_60348957_ENST00000400320_length(amino acids)=204AA_BP=64
MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDEGDETGVMDNLLEALQSGAAFRDRRK
RTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVESNRKKETEL

--------------------------------------------------------------
>54823_54823_17_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000474559_DIAPH3_chr13_60348957_ENST00000400324_length(transcript)=1749nt_BP=329nt
GCTGTGGTCACAACTAGGGCCTGGGCTCATGCATTGAACTGATCTGGCTGAGGCATCAGACACGGTGCCAGTCCTGCCCTGCGGGGAAGA
CAAGAGCACAAAGTGACAAGCCAGTGTGGTCTGACCTACGAGAAACATGGCAACCAGCGCCGTCCCCAGTGACAACCTCCCCACATACAA
GCTGGTGGTGGTGGGGGATGGGGGTGTGGGCAAAAGTGCCCTCACCATCCAGTTTTTCCAGAAGATCTTTGTGCCTGACTATGACCCCAC
CATTGAAGACTCCTACCTGAAACATACGGAGATTGACAATCAATGGGCCATCTTGGACGAGGGTGATGAGACAGGAGTGATGGATAATCT
GCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAAAAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAAT
GTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGAAAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTG
CAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATCTAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAA
GGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAACTTCTTGGCTCTTTTTCTAAAAATGAATCAGTTCCCGAAGTTGAAGC
CCTGCTGGCAAGATTACGAGCTTTATAAGTTAAACTGGTTTTTAAAAAAAATGATTAAGCCAAATATAAAGCCATGCTCTAAACTATAAC
ACTTGAAAAAATTGCTTTTATGTAAGTGACTTTATATAGTTTTAAATTATGATATATATTAGAAAAATAAAGCTAAATATATGATTGCAA
TGCTTTTTCTATGTACTGGAGGTTTTGGTTTATTCAAGATTGTACCGGGCTTTAATCCTTTTTTTTTTTTTTTTGTCTCCTGGTATTCCT
CAGTTCTTTATTTGGTGGTTAAATTATACATATTGCTTTAGAGAGCAGGTAGGTGGCCATGTGTTCAGCAGTGTGTCCTTAAGAAAATAC
CATCTTTCTAAGCCACTGGAATTTTTACTTTACTATTTTTAACATTAATGGATGTCAGGTCATCAACCTCAAGTCTTTACATATCCATGT
ATATTCCATATATATTGTTTATATAGGCCCAAGTTTCTCCTTAATTGGGATCTATATACTACCAGCACAACATCAAAAACATGTAATTGA
ATACATCAGAGCTATATATGTAAGGAAATGACTGGTGACCCCATTATCATCATTGTTGAATTCATGTTAAGTAGACCCTCTAGGGGACCA
TAAGGCAATTGAGCACATAACGAAAAATGATGCAATAAGAATGTATGCACTCTCTTTGCCAAATGCATGTGCTTTTGTGTAACGTGGATG
TAAACAGAATTGCAGTGCTGCCGAAATTCTTGATCTTGGCTAAGAGAGTATTTTTCCCCTTGTAATTATGACTCTGAGATAAAATTGCCA
TTTTGAAATTTCCAAAGTAACAACTTTTTTTATTTTATGAATAAACTTGGGATTGCAATTTCTCTGATCTGACAATCAATAACTTTAACA
AAGATCTAAATAAGTGTTTCAAGGAAAGTTTTCCTAAGCAAATGTAATATTACCTCATTTGGGCATCATTACTCTGTTAATTCTATATCA

>54823_54823_17_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000474559_DIAPH3_chr13_60348957_ENST00000400324_length(amino acids)=203AA_BP=64
MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDEGDETGVMDNLLEALQSGAAFRDRRK
RTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVESNRKKETEL

--------------------------------------------------------------
>54823_54823_18_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000474559_DIAPH3_chr13_60348957_ENST00000400330_length(transcript)=1741nt_BP=329nt
GCTGTGGTCACAACTAGGGCCTGGGCTCATGCATTGAACTGATCTGGCTGAGGCATCAGACACGGTGCCAGTCCTGCCCTGCGGGGAAGA
CAAGAGCACAAAGTGACAAGCCAGTGTGGTCTGACCTACGAGAAACATGGCAACCAGCGCCGTCCCCAGTGACAACCTCCCCACATACAA
GCTGGTGGTGGTGGGGGATGGGGGTGTGGGCAAAAGTGCCCTCACCATCCAGTTTTTCCAGAAGATCTTTGTGCCTGACTATGACCCCAC
CATTGAAGACTCCTACCTGAAACATACGGAGATTGACAATCAATGGGCCATCTTGGACGAGGGTGATGAGACAGGAGTGATGGATAATCT
GCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAAAAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAAT
GTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGAAAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTG
CAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATCTAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAA
GGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAACTTCTTGGCTCTTTTTCTAAAAATGAATCAGTTCCCGAAGTTGAAGC
CCTGCTGGCAAGATTACGAGCTTTATAAGTTAAACTGGTTTTTAAAAAAAATGATTAAGCCAAATATAAAGCCATGCTCTAAACTATAAC
ACTTGAAAAAATTGCTTTTATGTAAGTGACTTTATATAGTTTTAAATTATGATATATATTAGAAAAATAAAGCTAAATATATGATTGCAA
TGCTTTTTCTATGTACTGGAGGTTTTGGTTTATTCAAGATTGTACCGGGCTTTAATCCTTTTTTTTTTTTTTTTGTCTCCTGGTATTCCT
CAGTTCTTTATTTGGTGGTTAAATTATACATATTGCTTTAGAGAGCAGGTAGGTGGCCATGTGTTCAGCAGTGTGTCCTTAAGAAAATAC
CATCTTTCTAAGCCACTGGAATTTTTACTTTACTATTTTTAACATTAATGGATGTCAGGTCATCAACCTCAAGTCTTTACATATCCATGT
ATATTCCATATATATTGTTTATATAGGCCCAAGTTTCTCCTTAATTGGGATCTATATACTACCAGCACAACATCAAAAACATGTAATTGA
ATACATCAGAGCTATATATGTAAGGAAATGACTGGTGACCCCATTATCATCATTGTTGAATTCATGTTAAGTAGACCCTCTAGGGGACCA
TAAGGCAATTGAGCACATAACGAAAAATGATGCAATAAGAATGTATGCACTCTCTTTGCCAAATGCATGTGCTTTTGTGTAACGTGGATG
TAAACAGAATTGCAGTGCTGCCGAAATTCTTGATCTTGGCTAAGAGAGTATTTTTCCCCTTGTAATTATGACTCTGAGATAAAATTGCCA
TTTTGAAATTTCCAAAGTAACAACTTTTTTTATTTTATGAATAAACTTGGGATTGCAATTTCTCTGATCTGACAATCAATAACTTTAACA
AAGATCTAAATAAGTGTTTCAAGGAAAGTTTTCCTAAGCAAATGTAATATTACCTCATTTGGGCATCATTACTCTGTTAATTCTATATCA

>54823_54823_18_MRAS-DIAPH3_MRAS_chr3_138091918_ENST00000474559_DIAPH3_chr13_60348957_ENST00000400330_length(amino acids)=203AA_BP=64
MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDEGDETGVMDNLLEALQSGAAFRDRRK
RTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVESNRKKETEL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MRAS-DIAPH3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MRAS-DIAPH3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MRAS-DIAPH3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource