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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MRAS-NME9 (FusionGDB2 ID:54824)

Fusion Gene Summary for MRAS-NME9

check button Fusion gene summary
Fusion gene informationFusion gene name: MRAS-NME9
Fusion gene ID: 54824
HgeneTgene
Gene symbol

MRAS

NME9

Gene ID

22808

347736

Gene namemuscle RAS oncogene homologNME/NM23 family member 9
SynonymsM-RAs|NS11|R-RAS3|RRAS3NM23-H9|NXL2|TXL-2|TXL2|TXNDC6
Cytomap

3q22.3

3q22.3

Type of geneprotein-codingprotein-coding
Descriptionras-related protein M-Rasmuscle and microspikes RASras-related protein R-Ras3thioredoxin domain-containing protein 6NME gene family member 9thioredoxin-like protein 2
Modification date2020031320200313
UniProtAcc

O14807

Q86XW9

Ensembl transtripts involved in fusion geneENST00000289104, ENST00000423968, 
ENST00000474559, ENST00000461114, 
ENST00000464896, 		ENST00000317876, 
ENST00000333911, ENST00000341790, 
ENST00000383180, ENST00000484930, 
ENST00000536478, 
Fusion gene scores* DoF score3 X 1 X 3=93 X 3 X 3=27
# samples 33
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MRAS [Title/Abstract] AND NME9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMRAS(138091918)-NME9(138025322), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MRAS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NME9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A1KR-01AMRASchr3

138091918

+NME9chr3

138022485

-
ChimerDB4BRCATCGA-AO-A1KR-01AMRASchr3

138091918

+NME9chr3

138025322

-


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Fusion Gene ORF analysis for MRAS-NME9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000289104ENST00000317876MRASchr3

138091918

+NME9chr3

138022485

-
Frame-shiftENST00000289104ENST00000333911MRASchr3

138091918

+NME9chr3

138022485

-
Frame-shiftENST00000289104ENST00000341790MRASchr3

138091918

+NME9chr3

138022485

-
Frame-shiftENST00000289104ENST00000383180MRASchr3

138091918

+NME9chr3

138022485

-
Frame-shiftENST00000289104ENST00000484930MRASchr3

138091918

+NME9chr3

138022485

-
Frame-shiftENST00000289104ENST00000536478MRASchr3

138091918

+NME9chr3

138022485

-
Frame-shiftENST00000423968ENST00000317876MRASchr3

138091918

+NME9chr3

138022485

-
Frame-shiftENST00000423968ENST00000333911MRASchr3

138091918

+NME9chr3

138022485

-
Frame-shiftENST00000423968ENST00000341790MRASchr3

138091918

+NME9chr3

138022485

-
Frame-shiftENST00000423968ENST00000383180MRASchr3

138091918

+NME9chr3

138022485

-
Frame-shiftENST00000423968ENST00000484930MRASchr3

138091918

+NME9chr3

138022485

-
Frame-shiftENST00000423968ENST00000536478MRASchr3

138091918

+NME9chr3

138022485

-
Frame-shiftENST00000474559ENST00000317876MRASchr3

138091918

+NME9chr3

138022485

-
Frame-shiftENST00000474559ENST00000333911MRASchr3

138091918

+NME9chr3

138022485

-
Frame-shiftENST00000474559ENST00000341790MRASchr3

138091918

+NME9chr3

138022485

-
Frame-shiftENST00000474559ENST00000383180MRASchr3

138091918

+NME9chr3

138022485

-
Frame-shiftENST00000474559ENST00000484930MRASchr3

138091918

+NME9chr3

138022485

-
Frame-shiftENST00000474559ENST00000536478MRASchr3

138091918

+NME9chr3

138022485

-
In-frameENST00000289104ENST00000317876MRASchr3

138091918

+NME9chr3

138025322

-
In-frameENST00000289104ENST00000333911MRASchr3

138091918

+NME9chr3

138025322

-
In-frameENST00000289104ENST00000341790MRASchr3

138091918

+NME9chr3

138025322

-
In-frameENST00000289104ENST00000383180MRASchr3

138091918

+NME9chr3

138025322

-
In-frameENST00000289104ENST00000484930MRASchr3

138091918

+NME9chr3

138025322

-
In-frameENST00000289104ENST00000536478MRASchr3

138091918

+NME9chr3

138025322

-
In-frameENST00000423968ENST00000317876MRASchr3

138091918

+NME9chr3

138025322

-
In-frameENST00000423968ENST00000333911MRASchr3

138091918

+NME9chr3

138025322

-
In-frameENST00000423968ENST00000341790MRASchr3

138091918

+NME9chr3

138025322

-
In-frameENST00000423968ENST00000383180MRASchr3

138091918

+NME9chr3

138025322

-
In-frameENST00000423968ENST00000484930MRASchr3

138091918

+NME9chr3

138025322

-
In-frameENST00000423968ENST00000536478MRASchr3

138091918

+NME9chr3

138025322

-
In-frameENST00000474559ENST00000317876MRASchr3

138091918

+NME9chr3

138025322

-
In-frameENST00000474559ENST00000333911MRASchr3

138091918

+NME9chr3

138025322

-
In-frameENST00000474559ENST00000341790MRASchr3

138091918

+NME9chr3

138025322

-
In-frameENST00000474559ENST00000383180MRASchr3

138091918

+NME9chr3

138025322

-
In-frameENST00000474559ENST00000484930MRASchr3

138091918

+NME9chr3

138025322

-
In-frameENST00000474559ENST00000536478MRASchr3

138091918

+NME9chr3

138025322

-
intron-3CDSENST00000461114ENST00000317876MRASchr3

138091918

+NME9chr3

138022485

-
intron-3CDSENST00000461114ENST00000317876MRASchr3

138091918

+NME9chr3

138025322

-
intron-3CDSENST00000461114ENST00000333911MRASchr3

138091918

+NME9chr3

138022485

-
intron-3CDSENST00000461114ENST00000333911MRASchr3

138091918

+NME9chr3

138025322

-
intron-3CDSENST00000461114ENST00000341790MRASchr3

138091918

+NME9chr3

138022485

-
intron-3CDSENST00000461114ENST00000341790MRASchr3

138091918

+NME9chr3

138025322

-
intron-3CDSENST00000461114ENST00000383180MRASchr3

138091918

+NME9chr3

138022485

-
intron-3CDSENST00000461114ENST00000383180MRASchr3

138091918

+NME9chr3

138025322

-
intron-3CDSENST00000461114ENST00000484930MRASchr3

138091918

+NME9chr3

138022485

-
intron-3CDSENST00000461114ENST00000484930MRASchr3

138091918

+NME9chr3

138025322

-
intron-3CDSENST00000461114ENST00000536478MRASchr3

138091918

+NME9chr3

138022485

-
intron-3CDSENST00000461114ENST00000536478MRASchr3

138091918

+NME9chr3

138025322

-
intron-3CDSENST00000464896ENST00000317876MRASchr3

138091918

+NME9chr3

138022485

-
intron-3CDSENST00000464896ENST00000317876MRASchr3

138091918

+NME9chr3

138025322

-
intron-3CDSENST00000464896ENST00000333911MRASchr3

138091918

+NME9chr3

138022485

-
intron-3CDSENST00000464896ENST00000333911MRASchr3

138091918

+NME9chr3

138025322

-
intron-3CDSENST00000464896ENST00000341790MRASchr3

138091918

+NME9chr3

138022485

-
intron-3CDSENST00000464896ENST00000341790MRASchr3

138091918

+NME9chr3

138025322

-
intron-3CDSENST00000464896ENST00000383180MRASchr3

138091918

+NME9chr3

138022485

-
intron-3CDSENST00000464896ENST00000383180MRASchr3

138091918

+NME9chr3

138025322

-
intron-3CDSENST00000464896ENST00000484930MRASchr3

138091918

+NME9chr3

138022485

-
intron-3CDSENST00000464896ENST00000484930MRASchr3

138091918

+NME9chr3

138025322

-
intron-3CDSENST00000464896ENST00000536478MRASchr3

138091918

+NME9chr3

138022485

-
intron-3CDSENST00000464896ENST00000536478MRASchr3

138091918

+NME9chr3

138025322

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MRAS-NME9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MRAS-NME9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:138091918/chr3:138025322)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MRAS

O14807

NME9

Q86XW9

FUNCTION: Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway. {ECO:0000269|PubMed:16630891, ECO:0000269|PubMed:28289718}.FUNCTION: May be a regulator of microtubule physiology. {ECO:0000305|PubMed:12569107}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMRASchr3:138091918chr3:138025322ENST00000289104+2642_5064209.0MotifNote=Effector region
HgeneMRASchr3:138091918chr3:138025322ENST00000423968+2642_5064209.0MotifNote=Effector region
HgeneMRASchr3:138091918chr3:138025322ENST00000474559+2642_5064209.0MotifNote=Effector region
HgeneMRASchr3:138091918chr3:138025322ENST00000289104+2620_2764209.0Nucleotide bindingGTP
HgeneMRASchr3:138091918chr3:138025322ENST00000423968+2620_2764209.0Nucleotide bindingGTP
HgeneMRASchr3:138091918chr3:138025322ENST00000474559+2620_2764209.0Nucleotide bindingGTP
TgeneNME9chr3:138091918chr3:138025322ENST0000031787639157_30392264.0RegionNote=NDK
TgeneNME9chr3:138091918chr3:138025322ENST00000333911511157_303153331.0RegionNote=NDK
TgeneNME9chr3:138091918chr3:138025322ENST0000034179039157_30390262.0RegionNote=NDK
TgeneNME9chr3:138091918chr3:138025322ENST00000383180612157_30392264.0RegionNote=NDK
TgeneNME9chr3:138091918chr3:138025322ENST00000484930410157_30390262.0RegionNote=NDK
TgeneNME9chr3:138091918chr3:138025322ENST00000536478410157_30392264.0RegionNote=NDK

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMRASchr3:138091918chr3:138025322ENST00000289104+26185_19164209.0Compositional biasNote=Poly-Lys
HgeneMRASchr3:138091918chr3:138025322ENST00000423968+26185_19164209.0Compositional biasNote=Poly-Lys
HgeneMRASchr3:138091918chr3:138025322ENST00000464896+15185_1910133.0Compositional biasNote=Poly-Lys
HgeneMRASchr3:138091918chr3:138025322ENST00000474559+26185_19164209.0Compositional biasNote=Poly-Lys
HgeneMRASchr3:138091918chr3:138025322ENST00000464896+1542_500133.0MotifNote=Effector region
HgeneMRASchr3:138091918chr3:138025322ENST00000289104+26126_12964209.0Nucleotide bindingGTP
HgeneMRASchr3:138091918chr3:138025322ENST00000289104+2667_7164209.0Nucleotide bindingGTP
HgeneMRASchr3:138091918chr3:138025322ENST00000423968+26126_12964209.0Nucleotide bindingGTP
HgeneMRASchr3:138091918chr3:138025322ENST00000423968+2667_7164209.0Nucleotide bindingGTP
HgeneMRASchr3:138091918chr3:138025322ENST00000464896+15126_1290133.0Nucleotide bindingGTP
HgeneMRASchr3:138091918chr3:138025322ENST00000464896+1520_270133.0Nucleotide bindingGTP
HgeneMRASchr3:138091918chr3:138025322ENST00000464896+1567_710133.0Nucleotide bindingGTP
HgeneMRASchr3:138091918chr3:138025322ENST00000474559+26126_12964209.0Nucleotide bindingGTP
HgeneMRASchr3:138091918chr3:138025322ENST00000474559+2667_7164209.0Nucleotide bindingGTP
TgeneNME9chr3:138091918chr3:138025322ENST000003178763911_11592264.0DomainNote=Thioredoxin
TgeneNME9chr3:138091918chr3:138025322ENST0000033391151111_115153331.0DomainNote=Thioredoxin
TgeneNME9chr3:138091918chr3:138025322ENST000003417903911_11590262.0DomainNote=Thioredoxin
TgeneNME9chr3:138091918chr3:138025322ENST0000038318061211_11592264.0DomainNote=Thioredoxin
TgeneNME9chr3:138091918chr3:138025322ENST0000048493041011_11590262.0DomainNote=Thioredoxin
TgeneNME9chr3:138091918chr3:138025322ENST0000053647841011_11592264.0DomainNote=Thioredoxin


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Fusion Gene Sequence for MRAS-NME9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MRAS-NME9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MRAS-NME9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MRAS-NME9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource