FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MROH1-HSF1 (FusionGDB2 ID:54880)

Fusion Gene Summary for MROH1-HSF1

check button Fusion gene summary
Fusion gene informationFusion gene name: MROH1-HSF1
Fusion gene ID: 54880
HgeneTgene
Gene symbol

MROH1

HSF1

Gene ID

727957

3297

Gene namemaestro heat like repeat family member 1heat shock transcription factor 1
SynonymsHEATR7AHSTF1
Cytomap

8q24.3

8q24.3

Type of geneprotein-codingprotein-coding
Descriptionmaestro heat-like repeat-containing protein family member 1HEAT repeat containing 7AHEAT repeat-containing protein 7Aheat shock factor protein 1
Modification date2020032020200322
UniProtAcc

Q8NDA8

Q00613

Ensembl transtripts involved in fusion geneENST00000326134, ENST00000398656, 
ENST00000528919, ENST00000534366, 
ENST00000423230, ENST00000527071, 
ENST00000544576, 		ENST00000528842, 
ENST00000400780, ENST00000528838, 
Fusion gene scores* DoF score18 X 8 X 8=11528 X 9 X 5=360
# samples 199
** MAII scorelog2(19/1152*10)=-2.60006939311136
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MROH1 [Title/Abstract] AND HSF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHSF1(145515556)-MROH1(145305115), # samples:1
MROH1(145278133)-HSF1(145532592), # samples:1
Anticipated loss of major functional domain due to fusion event.MROH1-HSF1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
MROH1-HSF1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHSF1

GO:0000122

negative regulation of transcription by RNA polymerase II

8926278|9341107

TgeneHSF1

GO:0000165

MAPK cascade

12917326

TgeneHSF1

GO:0009299

mRNA transcription

21597468

TgeneHSF1

GO:0034605

cellular response to heat

7935471|9222587|9341107|10359787|10413683|10747973|11514557|11583998|12917326|14707147|16554823|17897941|21085490|26159920

TgeneHSF1

GO:0034620

cellular response to unfolded protein

15016915

TgeneHSF1

GO:0034622

cellular protein-containing complex assembly

11583998

TgeneHSF1

GO:0045944

positive regulation of transcription by RNA polymerase II

9341107|10561509|11514557|12917326|16278218|21085490

TgeneHSF1

GO:0061408

positive regulation of transcription from RNA polymerase II promoter in response to heat stress

7760831|9499401|10747973|12659875|12665592|15016915|25963659|26754925

TgeneHSF1

GO:0071276

cellular response to cadmium ion

10359787|11514557|15016915|25963659

TgeneHSF1

GO:0071280

cellular response to copper ion

15016915

TgeneHSF1

GO:0071480

cellular response to gamma radiation

26359349

TgeneHSF1

GO:0072738

cellular response to diamide

15016915

TgeneHSF1

GO:1900034

regulation of cellular response to heat

11583998

TgeneHSF1

GO:1903936

cellular response to sodium arsenite

15016915


check buttonFusion gene breakpoints across MROH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HSF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8690-01AMROH1chr8

145278133

+HSF1chr8

145532592

+


Top

Fusion Gene ORF analysis for MROH1-HSF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000326134ENST00000528842MROH1chr8

145278133

+HSF1chr8

145532592

+
5CDS-intronENST00000398656ENST00000528842MROH1chr8

145278133

+HSF1chr8

145532592

+
5CDS-intronENST00000528919ENST00000528842MROH1chr8

145278133

+HSF1chr8

145532592

+
5CDS-intronENST00000534366ENST00000528842MROH1chr8

145278133

+HSF1chr8

145532592

+
Frame-shiftENST00000326134ENST00000400780MROH1chr8

145278133

+HSF1chr8

145532592

+
Frame-shiftENST00000398656ENST00000400780MROH1chr8

145278133

+HSF1chr8

145532592

+
Frame-shiftENST00000528919ENST00000400780MROH1chr8

145278133

+HSF1chr8

145532592

+
Frame-shiftENST00000534366ENST00000400780MROH1chr8

145278133

+HSF1chr8

145532592

+
In-frameENST00000326134ENST00000528838MROH1chr8

145278133

+HSF1chr8

145532592

+
In-frameENST00000398656ENST00000528838MROH1chr8

145278133

+HSF1chr8

145532592

+
In-frameENST00000528919ENST00000528838MROH1chr8

145278133

+HSF1chr8

145532592

+
In-frameENST00000534366ENST00000528838MROH1chr8

145278133

+HSF1chr8

145532592

+
intron-3CDSENST00000423230ENST00000400780MROH1chr8

145278133

+HSF1chr8

145532592

+
intron-3CDSENST00000423230ENST00000528838MROH1chr8

145278133

+HSF1chr8

145532592

+
intron-3CDSENST00000527071ENST00000400780MROH1chr8

145278133

+HSF1chr8

145532592

+
intron-3CDSENST00000527071ENST00000528838MROH1chr8

145278133

+HSF1chr8

145532592

+
intron-3CDSENST00000544576ENST00000400780MROH1chr8

145278133

+HSF1chr8

145532592

+
intron-3CDSENST00000544576ENST00000528838MROH1chr8

145278133

+HSF1chr8

145532592

+
intron-intronENST00000423230ENST00000528842MROH1chr8

145278133

+HSF1chr8

145532592

+
intron-intronENST00000527071ENST00000528842MROH1chr8

145278133

+HSF1chr8

145532592

+
intron-intronENST00000544576ENST00000528842MROH1chr8

145278133

+HSF1chr8

145532592

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398656MROH1chr8145278133+ENST00000528838HSF1chr8145532592+33001435972907936
ENST00000534366MROH1chr8145278133+ENST00000528838HSF1chr8145532592+332714621242934936
ENST00000528919MROH1chr8145278133+ENST00000528838HSF1chr8145532592+33241459372931964
ENST00000326134MROH1chr8145278133+ENST00000528838HSF1chr8145532592+32601395572867936

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398656ENST00000528838MROH1chr8145278133+HSF1chr8145532592+0.0123976840.9876023
ENST00000534366ENST00000528838MROH1chr8145278133+HSF1chr8145532592+0.0122095240.98779047
ENST00000528919ENST00000528838MROH1chr8145278133+HSF1chr8145532592+0.0125756030.98742443
ENST00000326134ENST00000528838MROH1chr8145278133+HSF1chr8145532592+0.011963110.9880369

Top

Fusion Genomic Features for MROH1-HSF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for MROH1-HSF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:145515556/chr8:145305115)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MROH1

Q8NDA8

HSF1

Q00613

FUNCTION: Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage (PubMed:1871105, PubMed:11447121, PubMed:1986252, PubMed:7760831, PubMed:7623826, PubMed:8946918, PubMed:8940068, PubMed:9341107, PubMed:9121459, PubMed:9727490, PubMed:9499401, PubMed:9535852, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:25963659, PubMed:26754925). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:9727490, PubMed:11583998, PubMed:16278218). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:1871105, PubMed:1986252, PubMed:8455624, PubMed:7935471, PubMed:7623826, PubMed:8940068, PubMed:9727490, PubMed:9499401, PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:25963659, PubMed:26754925). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Plays also several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Plays also a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925). {ECO:0000269|PubMed:10359787, ECO:0000269|PubMed:11447121, ECO:0000269|PubMed:11583998, ECO:0000269|PubMed:12659875, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:14707147, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:1871105, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:1986252, ECO:0000269|PubMed:25963659, ECO:0000269|PubMed:26359349, ECO:0000269|PubMed:26727489, ECO:0000269|PubMed:26754925, ECO:0000269|PubMed:7623826, ECO:0000269|PubMed:7760831, ECO:0000269|PubMed:7935471, ECO:0000269|PubMed:8455624, ECO:0000269|PubMed:8940068, ECO:0000269|PubMed:8946918, ECO:0000269|PubMed:9121459, ECO:0000269|PubMed:9341107, ECO:0000269|PubMed:9499401, ECO:0000269|PubMed:9535852, ECO:0000269|PubMed:9727490}.; FUNCTION: (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300. {ECO:0000269|PubMed:27189267}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMROH1chr8:145278133chr8:145532592ENST00000326134+1242159_1984461642.0RepeatNote=HEAT 2
HgeneMROH1chr8:145278133chr8:145532592ENST00000326134+1242344_3824461642.0RepeatNote=HEAT 3
HgeneMROH1chr8:145278133chr8:145532592ENST00000326134+1242385_4234461642.0RepeatNote=HEAT 4
HgeneMROH1chr8:145278133chr8:145532592ENST00000326134+12423_414461642.0RepeatNote=HEAT 1
HgeneMROH1chr8:145278133chr8:145532592ENST00000398656+1343159_1984461642.0RepeatNote=HEAT 2
HgeneMROH1chr8:145278133chr8:145532592ENST00000398656+1343344_3824461642.0RepeatNote=HEAT 3
HgeneMROH1chr8:145278133chr8:145532592ENST00000398656+1343385_4234461642.0RepeatNote=HEAT 4
HgeneMROH1chr8:145278133chr8:145532592ENST00000398656+13433_414461642.0RepeatNote=HEAT 1
HgeneMROH1chr8:145278133chr8:145532592ENST00000528919+1343159_1984461642.0RepeatNote=HEAT 2
HgeneMROH1chr8:145278133chr8:145532592ENST00000528919+1343344_3824461642.0RepeatNote=HEAT 3
HgeneMROH1chr8:145278133chr8:145532592ENST00000528919+1343385_4234461642.0RepeatNote=HEAT 4
HgeneMROH1chr8:145278133chr8:145532592ENST00000528919+13433_414461642.0RepeatNote=HEAT 1
TgeneHSF1chr8:145278133chr8:145532592ENST00000528838013412_42039530.0Motif9aaTAD
TgeneHSF1chr8:145278133chr8:145532592ENST00000528838013130_20339530.0RegionHydrophobic repeat HR-A/B
TgeneHSF1chr8:145278133chr8:145532592ENST00000528838013203_22439530.0RegionD domain
TgeneHSF1chr8:145278133chr8:145532592ENST00000528838013221_31039530.0RegionRegulatory domain
TgeneHSF1chr8:145278133chr8:145532592ENST00000528838013371_52939530.0RegionTransactivation domain
TgeneHSF1chr8:145278133chr8:145532592ENST00000528838013384_40939530.0RegionHydrophobic repeat HR-C

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMROH1chr8:145278133chr8:145532592ENST00000326134+12421048_10864461642.0RepeatNote=HEAT 5
HgeneMROH1chr8:145278133chr8:145532592ENST00000326134+12421358_13964461642.0RepeatNote=HEAT 6
HgeneMROH1chr8:145278133chr8:145532592ENST00000326134+12421605_16414461642.0RepeatNote=HEAT 7
HgeneMROH1chr8:145278133chr8:145532592ENST00000398656+13431048_10864461642.0RepeatNote=HEAT 5
HgeneMROH1chr8:145278133chr8:145532592ENST00000398656+13431358_13964461642.0RepeatNote=HEAT 6
HgeneMROH1chr8:145278133chr8:145532592ENST00000398656+13431605_16414461642.0RepeatNote=HEAT 7
HgeneMROH1chr8:145278133chr8:145532592ENST00000423230+1121048_10860423.0RepeatNote=HEAT 5
HgeneMROH1chr8:145278133chr8:145532592ENST00000423230+1121358_13960423.0RepeatNote=HEAT 6
HgeneMROH1chr8:145278133chr8:145532592ENST00000423230+112159_1980423.0RepeatNote=HEAT 2
HgeneMROH1chr8:145278133chr8:145532592ENST00000423230+1121605_16410423.0RepeatNote=HEAT 7
HgeneMROH1chr8:145278133chr8:145532592ENST00000423230+112344_3820423.0RepeatNote=HEAT 3
HgeneMROH1chr8:145278133chr8:145532592ENST00000423230+112385_4230423.0RepeatNote=HEAT 4
HgeneMROH1chr8:145278133chr8:145532592ENST00000423230+1123_410423.0RepeatNote=HEAT 1
HgeneMROH1chr8:145278133chr8:145532592ENST00000528919+13431048_10864461642.0RepeatNote=HEAT 5
HgeneMROH1chr8:145278133chr8:145532592ENST00000528919+13431358_13964461642.0RepeatNote=HEAT 6
HgeneMROH1chr8:145278133chr8:145532592ENST00000528919+13431605_16414461642.0RepeatNote=HEAT 7
HgeneMROH1chr8:145278133chr8:145532592ENST00000544576+1261048_10860616.0RepeatNote=HEAT 5
HgeneMROH1chr8:145278133chr8:145532592ENST00000544576+1261358_13960616.0RepeatNote=HEAT 6
HgeneMROH1chr8:145278133chr8:145532592ENST00000544576+126159_1980616.0RepeatNote=HEAT 2
HgeneMROH1chr8:145278133chr8:145532592ENST00000544576+1261605_16410616.0RepeatNote=HEAT 7
HgeneMROH1chr8:145278133chr8:145532592ENST00000544576+126344_3820616.0RepeatNote=HEAT 3
HgeneMROH1chr8:145278133chr8:145532592ENST00000544576+126385_4230616.0RepeatNote=HEAT 4
HgeneMROH1chr8:145278133chr8:145532592ENST00000544576+1263_410616.0RepeatNote=HEAT 1
TgeneHSF1chr8:145278133chr8:145532592ENST0000052883801315_12039530.0RegionDNA-binding domain


Top

Fusion Gene Sequence for MROH1-HSF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>54880_54880_1_MROH1-HSF1_MROH1_chr8_145278133_ENST00000326134_HSF1_chr8_145532592_ENST00000528838_length(transcript)=3260nt_BP=1395nt
GATGGGAGAAGAAGTTGTCCATGTTCACACTGGGTGAAGGAAGCTGAAACCACAGACATGACTGAGTCCTCCATGAAGAAGCTGGCCTCC
ACCCTGCTGGACGCCATCACCGATAAGGACCCCCTGGTGCAGGAGCAGGTCTGCAGTGCCCTGTGCTCCCTCGGGGAGGCGCGGCCGGTG
GAGACGCTCCGTGCCTGCGAGGAGTATCTGCGGCAGCATGACAAGCTGGCACACCCATACCGAGCAGCGGTCCTGAGGGCCATGGAGAGG
GTCCTGAGCAGTCGCGCCAGTGAGCTGGACAAGGACACAGCCAGCACCATCATCCTCCTGGCCTCCAGCGAGATGACCAAGACGAAGGAC
CTGGTCTGGGACTGGCAGCAGGCGGCGAGTGGCGTCCTGGTGGCCGTGGGAAGACAGTTCATCAGCAAGGTGATGGAGGAGCTGCTGCGC
AGGCTGCACCCTGGGACCCTGCCACACTGCGCCGTGCTGCACACCCTCGCCAGCCTCTCGGTGGCCAACGCGTTCGGCGTAGTCCCCTTC
CTGCCATCCGTCCTGAGCTCCCTGCTGCCCGTGCTGGGCGTGGCCAAGCAGGACACGGTGCGCGTGGCCTTCTGCTCCGCTCTGCAGCGC
TTCAGCGAGGGTGCCCTGGAGTACCTAGCCAACCTGGACCGAGCCCCAGACCCCACGGTCAGGAAGGACGCCTTTGCCACCGACATCTTC
AGCGCCTACGATGTTCTCTTCCATCAGTGGCTGCAGAGTCGAGAAGCCAAGCTCCGTCTTGCCGTGGTGGAGGCTCTGGGGCCTATGAGC
CATCTGCTGCCCAGTGAGAGGCTGGAAGAGCAGCTGCCCAAGCTCCTCCCTGGGATTCTCGCCCTCTACAAGAAGCACGCAGAGACCTTC
TACTTGTCCAAGAGCCTGGGCCAGATCCTCGAGGCAGCTGTGAGTGTGGGCAGCCGCACACTGGAGACCCAGCTGGATGCCCTCTTGGCT
GCACTGCACTCCCAGATCTGTGTGCCTGTGGAGTCCTCAAGCCCCCTGGTGATGAGTAACCAGAAGGAGGTGCTGCGCTGCTTCACTGTG
CTGGCCTGCAGCTCGCCTGACCGCCTACTGGCCTTCCTGCTGCCCAGGCTGGACACCAGCAATGAGAGGACCCGCGTGGGCACCCTGCAG
GTGGTCAGACATGTCATCAACTCAGCTGCTGCTCAGATGGAAGATAAAAAGCCCTTTATCCTGTCTTCCATGAGGCTTCCTCTCCTGGAC
ACCAACAGCAAGGTGAAGCGGGCAGTGGTGCAGGTGATTAGCGCCATGGCCCACCACGGCTACCTGGAGCAGCCTGGAGGTGAGGCGATG
ATCGAGTACATCGTGCAGCAGTGCGCGCTGCCCCCCGAGCAGGAGAGCGGGAACAGCTTCCACGTGTTCGACCAGGGCCAGTTTGCCAAG
GAGGTGCTGCCCAAGTACTTCAAGCACAACAACATGGCCAGCTTCGTGCGGCAGCTCAACATGTATGGCTTCCGGAAAGTGGTCCACATC
GAGCAGGGCGGCCTGGTCAAGCCAGAGAGAGACGACACGGAGTTCCAGCACCCATGCTTCCTGCGTGGCCAGGAGCAGCTCCTTGAGAAC
ATCAAGAGGAAAGTGACCAGTGTGTCCACCCTGAAGAGTGAAGACATAAAGATCCGCCAGGACAGCGTCACCAAGCTGCTGACGGACGTG
CAGCTGATGAAGGGGAAGCAGGAGTGCATGGACTCCAAGCTCCTGGCCATGAAGCATGAGAATGAGGCTCTGTGGCGGGAGGTGGCCAGC
CTTCGGCAGAAGCATGCCCAGCAACAGAAAGTCGTCAACAAGCTCATTCAGTTCCTGATCTCACTGGTGCAGTCAAACCGGATCCTGGGG
GTGAAGAGAAAGATCCCCCTGATGCTGAACGACAGTGGCTCAGCACATTCCATGCCCAAGTATAGCCGGCAGTTCTCCCTGGAGCACGTC
CACGGCTCGGGCCCCTACTCGGCCCCCTCCCCAGCCTACAGCAGCTCCAGCCTCTACGCCCCTGATGCTGTGGCCAGCTCTGGACCCATC
ATCTCCGACATCACCGAGCTGGCTCCTGCCAGCCCCATGGCCTCCCCCGGCGGGAGCATAGACGAGAGGCCCCTATCCAGCAGCCCCCTG
GTGCGTGTCAAGGAGGAGCCCCCCAGCCCGCCTCAGAGCCCCCGGGTAGAGGAGGCGAGTCCCGGGCGCCCATCTTCCGTGGACACCCTC
TTGTCCCCGACCGCCCTCATTGACTCCATCCTGCGGGAGAGTGAACCTGCCCCCGCCTCCGTCACAGCCCTCACGGACGCCAGGGGCCAC
ACGGACACCGAGGGCCGGCCTCCCTCCCCCCCGCCCACCTCCACCCCTGAAAAGTGCCTCAGCGTAGCCTGCCTGGACAAGAATGAGCTC
AGTGACCACTTGGATGCTATGGACTCCAACCTGGATAACCTGCAGACCATGCTGAGCAGCCACGGCTTCAGCGTGGACACCAGTGCCCTG
CTGGACCTGTTCAGCCCCTCGGTGACCGTGCCCGACATGAGCCTGCCTGACCTTGACAGCAGCCTGGCCAGTATCCAAGAGCTCCTGTCT
CCCCAGGAGCCCCCCAGGCCTCCCGAGGCAGAGAACAGCAGCCCGGATTCAGGGAAGCAGCTGGTGCACTACACAGCGCAGCCGCTGTTC
CTGCTGGACCCCGGCTCCGTGGACACCGGGAGCAACGACCTGCCGGTGCTGTTTGAGCTGGGAGAGGGCTCCTACTTCTCCGAAGGGGAC
GGCTTCGCCGAGGACCCCACCATCTCCCTGCTGACAGGCTCGGAGCCTCCCAAAGCCAAGGACCCCACTGTCTCCTAGAGGCCCCGGAGG
AGCTGGGCCAGCCGCCCACCCCCACCCCCAGTGCAGGGCTGGTCTTGGGGAGGCAGGGCAGCCTCGCGGTCTTGGGCACTGGTGGGTCGG
CCGCCATAGCCCCAGTAGGACAAACGGGCTCGGGTCTGGGCAGCACCTCTGGTCAGGAGGGTCACCCTGGCCTGCCAGTCTGCCTTCCCC
CAACCCCGTGTCCTGTGGTTTGGTTGGGGCTTCACAGCCACACCTGGACTGACCCTGCAGGTTGTTCATAGTCAGAATTGTATTTTGGAT
TTTTACACAACTGTCCCGTTCCCCGCTCCACAGAGATACACAGATATATACACACAGTGGATGGACGGACAAGACAGGCAGAGATCTATA

>54880_54880_1_MROH1-HSF1_MROH1_chr8_145278133_ENST00000326134_HSF1_chr8_145532592_ENST00000528838_length(amino acids)=936AA_BP=0
MTESSMKKLASTLLDAITDKDPLVQEQVCSALCSLGEARPVETLRACEEYLRQHDKLAHPYRAAVLRAMERVLSSRASELDKDTASTIIL
LASSEMTKTKDLVWDWQQAASGVLVAVGRQFISKVMEELLRRLHPGTLPHCAVLHTLASLSVANAFGVVPFLPSVLSSLLPVLGVAKQDT
VRVAFCSALQRFSEGALEYLANLDRAPDPTVRKDAFATDIFSAYDVLFHQWLQSREAKLRLAVVEALGPMSHLLPSERLEEQLPKLLPGI
LALYKKHAETFYLSKSLGQILEAAVSVGSRTLETQLDALLAALHSQICVPVESSSPLVMSNQKEVLRCFTVLACSSPDRLLAFLLPRLDT
SNERTRVGTLQVVRHVINSAAAQMEDKKPFILSSMRLPLLDTNSKVKRAVVQVISAMAHHGYLEQPGGEAMIEYIVQQCALPPEQESGNS
FHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIR
QDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMP
KYSRQFSLEHVHGSGPYSAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEEPPSPPQSPRVEEA
SPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGRPPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLS
SHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTAQPLFLLDPGSVDTGSNDLPVLFE

--------------------------------------------------------------
>54880_54880_2_MROH1-HSF1_MROH1_chr8_145278133_ENST00000398656_HSF1_chr8_145532592_ENST00000528838_length(transcript)=3300nt_BP=1435nt
GGGAAGGCGGCGCCCCGGCCGAGGTGGCGGCGGCTCCTCAGATGGGAGAAGAAGTTGTCCATGTTCACACTGGGTGAAGGAAGCTGAAAC
CACAGACATGACTGAGTCCTCCATGAAGAAGCTGGCCTCCACCCTGCTGGACGCCATCACCGATAAGGACCCCCTGGTGCAGGAGCAGGT
CTGCAGTGCCCTGTGCTCCCTCGGGGAGGCGCGGCCGGTGGAGACGCTCCGTGCCTGCGAGGAGTATCTGCGGCAGCATGACAAGCTGGC
ACACCCATACCGAGCAGCGGTCCTGAGGGCCATGGAGAGGGTCCTGAGCAGTCGCGCCAGTGAGCTGGACAAGGACACAGCCAGCACCAT
CATCCTCCTGGCCTCCAGCGAGATGACCAAGACGAAGGACCTGGTCTGGGACTGGCAGCAGGCGGCGAGTGGCGTCCTGGTGGCCGTGGG
AAGACAGTTCATCAGCAAGGTGATGGAGGAGCTGCTGCGCAGGCTGCACCCTGGGACCCTGCCACACTGCGCCGTGCTGCACACCCTCGC
CAGCCTCTCGGTGGCCAACGCGTTCGGCGTAGTCCCCTTCCTGCCATCCGTCCTGAGCTCCCTGCTGCCCGTGCTGGGCGTGGCCAAGCA
GGACACGGTGCGCGTGGCCTTCTGCTCCGCTCTGCAGCGCTTCAGCGAGGGTGCCCTGGAGTACCTAGCCAACCTGGACCGAGCCCCAGA
CCCCACGGTCAGGAAGGACGCCTTTGCCACCGACATCTTCAGCGCCTACGATGTTCTCTTCCATCAGTGGCTGCAGAGTCGAGAAGCCAA
GCTCCGTCTTGCCGTGGTGGAGGCTCTGGGGCCTATGAGCCATCTGCTGCCCAGTGAGAGGCTGGAAGAGCAGCTGCCCAAGCTCCTCCC
TGGGATTCTCGCCCTCTACAAGAAGCACGCAGAGACCTTCTACTTGTCCAAGAGCCTGGGCCAGATCCTCGAGGCAGCTGTGAGTGTGGG
CAGCCGCACACTGGAGACCCAGCTGGATGCCCTCTTGGCTGCACTGCACTCCCAGATCTGTGTGCCTGTGGAGTCCTCAAGCCCCCTGGT
GATGAGTAACCAGAAGGAGGTGCTGCGCTGCTTCACTGTGCTGGCCTGCAGCTCGCCTGACCGCCTACTGGCCTTCCTGCTGCCCAGGCT
GGACACCAGCAATGAGAGGACCCGCGTGGGCACCCTGCAGGTGGTCAGACATGTCATCAACTCAGCTGCTGCTCAGATGGAAGATAAAAA
GCCCTTTATCCTGTCTTCCATGAGGCTTCCTCTCCTGGACACCAACAGCAAGGTGAAGCGGGCAGTGGTGCAGGTGATTAGCGCCATGGC
CCACCACGGCTACCTGGAGCAGCCTGGAGGTGAGGCGATGATCGAGTACATCGTGCAGCAGTGCGCGCTGCCCCCCGAGCAGGAGAGCGG
GAACAGCTTCCACGTGTTCGACCAGGGCCAGTTTGCCAAGGAGGTGCTGCCCAAGTACTTCAAGCACAACAACATGGCCAGCTTCGTGCG
GCAGCTCAACATGTATGGCTTCCGGAAAGTGGTCCACATCGAGCAGGGCGGCCTGGTCAAGCCAGAGAGAGACGACACGGAGTTCCAGCA
CCCATGCTTCCTGCGTGGCCAGGAGCAGCTCCTTGAGAACATCAAGAGGAAAGTGACCAGTGTGTCCACCCTGAAGAGTGAAGACATAAA
GATCCGCCAGGACAGCGTCACCAAGCTGCTGACGGACGTGCAGCTGATGAAGGGGAAGCAGGAGTGCATGGACTCCAAGCTCCTGGCCAT
GAAGCATGAGAATGAGGCTCTGTGGCGGGAGGTGGCCAGCCTTCGGCAGAAGCATGCCCAGCAACAGAAAGTCGTCAACAAGCTCATTCA
GTTCCTGATCTCACTGGTGCAGTCAAACCGGATCCTGGGGGTGAAGAGAAAGATCCCCCTGATGCTGAACGACAGTGGCTCAGCACATTC
CATGCCCAAGTATAGCCGGCAGTTCTCCCTGGAGCACGTCCACGGCTCGGGCCCCTACTCGGCCCCCTCCCCAGCCTACAGCAGCTCCAG
CCTCTACGCCCCTGATGCTGTGGCCAGCTCTGGACCCATCATCTCCGACATCACCGAGCTGGCTCCTGCCAGCCCCATGGCCTCCCCCGG
CGGGAGCATAGACGAGAGGCCCCTATCCAGCAGCCCCCTGGTGCGTGTCAAGGAGGAGCCCCCCAGCCCGCCTCAGAGCCCCCGGGTAGA
GGAGGCGAGTCCCGGGCGCCCATCTTCCGTGGACACCCTCTTGTCCCCGACCGCCCTCATTGACTCCATCCTGCGGGAGAGTGAACCTGC
CCCCGCCTCCGTCACAGCCCTCACGGACGCCAGGGGCCACACGGACACCGAGGGCCGGCCTCCCTCCCCCCCGCCCACCTCCACCCCTGA
AAAGTGCCTCAGCGTAGCCTGCCTGGACAAGAATGAGCTCAGTGACCACTTGGATGCTATGGACTCCAACCTGGATAACCTGCAGACCAT
GCTGAGCAGCCACGGCTTCAGCGTGGACACCAGTGCCCTGCTGGACCTGTTCAGCCCCTCGGTGACCGTGCCCGACATGAGCCTGCCTGA
CCTTGACAGCAGCCTGGCCAGTATCCAAGAGCTCCTGTCTCCCCAGGAGCCCCCCAGGCCTCCCGAGGCAGAGAACAGCAGCCCGGATTC
AGGGAAGCAGCTGGTGCACTACACAGCGCAGCCGCTGTTCCTGCTGGACCCCGGCTCCGTGGACACCGGGAGCAACGACCTGCCGGTGCT
GTTTGAGCTGGGAGAGGGCTCCTACTTCTCCGAAGGGGACGGCTTCGCCGAGGACCCCACCATCTCCCTGCTGACAGGCTCGGAGCCTCC
CAAAGCCAAGGACCCCACTGTCTCCTAGAGGCCCCGGAGGAGCTGGGCCAGCCGCCCACCCCCACCCCCAGTGCAGGGCTGGTCTTGGGG
AGGCAGGGCAGCCTCGCGGTCTTGGGCACTGGTGGGTCGGCCGCCATAGCCCCAGTAGGACAAACGGGCTCGGGTCTGGGCAGCACCTCT
GGTCAGGAGGGTCACCCTGGCCTGCCAGTCTGCCTTCCCCCAACCCCGTGTCCTGTGGTTTGGTTGGGGCTTCACAGCCACACCTGGACT
GACCCTGCAGGTTGTTCATAGTCAGAATTGTATTTTGGATTTTTACACAACTGTCCCGTTCCCCGCTCCACAGAGATACACAGATATATA

>54880_54880_2_MROH1-HSF1_MROH1_chr8_145278133_ENST00000398656_HSF1_chr8_145532592_ENST00000528838_length(amino acids)=936AA_BP=0
MTESSMKKLASTLLDAITDKDPLVQEQVCSALCSLGEARPVETLRACEEYLRQHDKLAHPYRAAVLRAMERVLSSRASELDKDTASTIIL
LASSEMTKTKDLVWDWQQAASGVLVAVGRQFISKVMEELLRRLHPGTLPHCAVLHTLASLSVANAFGVVPFLPSVLSSLLPVLGVAKQDT
VRVAFCSALQRFSEGALEYLANLDRAPDPTVRKDAFATDIFSAYDVLFHQWLQSREAKLRLAVVEALGPMSHLLPSERLEEQLPKLLPGI
LALYKKHAETFYLSKSLGQILEAAVSVGSRTLETQLDALLAALHSQICVPVESSSPLVMSNQKEVLRCFTVLACSSPDRLLAFLLPRLDT
SNERTRVGTLQVVRHVINSAAAQMEDKKPFILSSMRLPLLDTNSKVKRAVVQVISAMAHHGYLEQPGGEAMIEYIVQQCALPPEQESGNS
FHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIR
QDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMP
KYSRQFSLEHVHGSGPYSAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEEPPSPPQSPRVEEA
SPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGRPPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLS
SHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTAQPLFLLDPGSVDTGSNDLPVLFE

--------------------------------------------------------------
>54880_54880_3_MROH1-HSF1_MROH1_chr8_145278133_ENST00000528919_HSF1_chr8_145532592_ENST00000528838_length(transcript)=3324nt_BP=1459nt
CCAGGCCACCTGCATTCCTTGTCTCAGAGCCTCCCTCCTGCATCCTCCAAGCCAGCAGTTGTGGGATGGGAGAAGAAGTTGTCCATGTTC
ACACTGGGTGAAGGAAGCTGAAACCACAGACATGACTGAGTCCTCCATGAAGAAGCTGGCCTCCACCCTGCTGGACGCCATCACCGATAA
GGACCCCCTGGTGCAGGAGCAGGTCTGCAGTGCCCTGTGCTCCCTCGGGGAGGCGCGGCCGGTGGAGACGCTCCGTGCCTGCGAGGAGTA
TCTGCGGCAGCATGACAAGCTGGCACACCCATACCGAGCAGCGGTCCTGAGGGCCATGGAGAGGGTCCTGAGCAGTCGCGCCAGTGAGCT
GGACAAGGACACAGCCAGCACCATCATCCTCCTGGCCTCCAGCGAGATGACCAAGACGAAGGACCTGGTCTGGGACTGGCAGCAGGCGGC
GAGTGGCGTCCTGGTGGCCGTGGGAAGACAGTTCATCAGCAAGGTGATGGAGGAGCTGCTGCGCAGGCTGCACCCTGGGACCCTGCCACA
CTGCGCCGTGCTGCACACCCTCGCCAGCCTCTCGGTGGCCAACGCGTTCGGCGTAGTCCCCTTCCTGCCATCCGTCCTGAGCTCCCTGCT
GCCCGTGCTGGGCGTGGCCAAGCAGGACACGGTGCGCGTGGCCTTCTGCTCCGCTCTGCAGCGCTTCAGCGAGGGTGCCCTGGAGTACCT
AGCCAACCTGGACCGAGCCCCAGACCCCACGGTCAGGAAGGACGCCTTTGCCACCGACATCTTCAGCGCCTACGATGTTCTCTTCCATCA
GTGGCTGCAGAGTCGAGAAGCCAAGCTCCGTCTTGCCGTGGTGGAGGCTCTGGGGCCTATGAGCCATCTGCTGCCCAGTGAGAGGCTGGA
AGAGCAGCTGCCCAAGCTCCTCCCTGGGATTCTCGCCCTCTACAAGAAGCACGCAGAGACCTTCTACTTGTCCAAGAGCCTGGGCCAGAT
CCTCGAGGCAGCTGTGAGTGTGGGCAGCCGCACACTGGAGACCCAGCTGGATGCCCTCTTGGCTGCACTGCACTCCCAGATCTGTGTGCC
TGTGGAGTCCTCAAGCCCCCTGGTGATGAGTAACCAGAAGGAGGTGCTGCGCTGCTTCACTGTGCTGGCCTGCAGCTCGCCTGACCGCCT
ACTGGCCTTCCTGCTGCCCAGGCTGGACACCAGCAATGAGAGGACCCGCGTGGGCACCCTGCAGGTGGTCAGACATGTCATCAACTCAGC
TGCTGCTCAGATGGAAGATAAAAAGCCCTTTATCCTGTCTTCCATGAGGCTTCCTCTCCTGGACACCAACAGCAAGGTGAAGCGGGCAGT
GGTGCAGGTGATTAGCGCCATGGCCCACCACGGCTACCTGGAGCAGCCTGGAGGTGAGGCGATGATCGAGTACATCGTGCAGCAGTGCGC
GCTGCCCCCCGAGCAGGAGAGCGGGAACAGCTTCCACGTGTTCGACCAGGGCCAGTTTGCCAAGGAGGTGCTGCCCAAGTACTTCAAGCA
CAACAACATGGCCAGCTTCGTGCGGCAGCTCAACATGTATGGCTTCCGGAAAGTGGTCCACATCGAGCAGGGCGGCCTGGTCAAGCCAGA
GAGAGACGACACGGAGTTCCAGCACCCATGCTTCCTGCGTGGCCAGGAGCAGCTCCTTGAGAACATCAAGAGGAAAGTGACCAGTGTGTC
CACCCTGAAGAGTGAAGACATAAAGATCCGCCAGGACAGCGTCACCAAGCTGCTGACGGACGTGCAGCTGATGAAGGGGAAGCAGGAGTG
CATGGACTCCAAGCTCCTGGCCATGAAGCATGAGAATGAGGCTCTGTGGCGGGAGGTGGCCAGCCTTCGGCAGAAGCATGCCCAGCAACA
GAAAGTCGTCAACAAGCTCATTCAGTTCCTGATCTCACTGGTGCAGTCAAACCGGATCCTGGGGGTGAAGAGAAAGATCCCCCTGATGCT
GAACGACAGTGGCTCAGCACATTCCATGCCCAAGTATAGCCGGCAGTTCTCCCTGGAGCACGTCCACGGCTCGGGCCCCTACTCGGCCCC
CTCCCCAGCCTACAGCAGCTCCAGCCTCTACGCCCCTGATGCTGTGGCCAGCTCTGGACCCATCATCTCCGACATCACCGAGCTGGCTCC
TGCCAGCCCCATGGCCTCCCCCGGCGGGAGCATAGACGAGAGGCCCCTATCCAGCAGCCCCCTGGTGCGTGTCAAGGAGGAGCCCCCCAG
CCCGCCTCAGAGCCCCCGGGTAGAGGAGGCGAGTCCCGGGCGCCCATCTTCCGTGGACACCCTCTTGTCCCCGACCGCCCTCATTGACTC
CATCCTGCGGGAGAGTGAACCTGCCCCCGCCTCCGTCACAGCCCTCACGGACGCCAGGGGCCACACGGACACCGAGGGCCGGCCTCCCTC
CCCCCCGCCCACCTCCACCCCTGAAAAGTGCCTCAGCGTAGCCTGCCTGGACAAGAATGAGCTCAGTGACCACTTGGATGCTATGGACTC
CAACCTGGATAACCTGCAGACCATGCTGAGCAGCCACGGCTTCAGCGTGGACACCAGTGCCCTGCTGGACCTGTTCAGCCCCTCGGTGAC
CGTGCCCGACATGAGCCTGCCTGACCTTGACAGCAGCCTGGCCAGTATCCAAGAGCTCCTGTCTCCCCAGGAGCCCCCCAGGCCTCCCGA
GGCAGAGAACAGCAGCCCGGATTCAGGGAAGCAGCTGGTGCACTACACAGCGCAGCCGCTGTTCCTGCTGGACCCCGGCTCCGTGGACAC
CGGGAGCAACGACCTGCCGGTGCTGTTTGAGCTGGGAGAGGGCTCCTACTTCTCCGAAGGGGACGGCTTCGCCGAGGACCCCACCATCTC
CCTGCTGACAGGCTCGGAGCCTCCCAAAGCCAAGGACCCCACTGTCTCCTAGAGGCCCCGGAGGAGCTGGGCCAGCCGCCCACCCCCACC
CCCAGTGCAGGGCTGGTCTTGGGGAGGCAGGGCAGCCTCGCGGTCTTGGGCACTGGTGGGTCGGCCGCCATAGCCCCAGTAGGACAAACG
GGCTCGGGTCTGGGCAGCACCTCTGGTCAGGAGGGTCACCCTGGCCTGCCAGTCTGCCTTCCCCCAACCCCGTGTCCTGTGGTTTGGTTG
GGGCTTCACAGCCACACCTGGACTGACCCTGCAGGTTGTTCATAGTCAGAATTGTATTTTGGATTTTTACACAACTGTCCCGTTCCCCGC

>54880_54880_3_MROH1-HSF1_MROH1_chr8_145278133_ENST00000528919_HSF1_chr8_145532592_ENST00000528838_length(amino acids)=964AA_BP=1
MHPPSQQLWDGRRSCPCSHWVKEAETTDMTESSMKKLASTLLDAITDKDPLVQEQVCSALCSLGEARPVETLRACEEYLRQHDKLAHPYR
AAVLRAMERVLSSRASELDKDTASTIILLASSEMTKTKDLVWDWQQAASGVLVAVGRQFISKVMEELLRRLHPGTLPHCAVLHTLASLSV
ANAFGVVPFLPSVLSSLLPVLGVAKQDTVRVAFCSALQRFSEGALEYLANLDRAPDPTVRKDAFATDIFSAYDVLFHQWLQSREAKLRLA
VVEALGPMSHLLPSERLEEQLPKLLPGILALYKKHAETFYLSKSLGQILEAAVSVGSRTLETQLDALLAALHSQICVPVESSSPLVMSNQ
KEVLRCFTVLACSSPDRLLAFLLPRLDTSNERTRVGTLQVVRHVINSAAAQMEDKKPFILSSMRLPLLDTNSKVKRAVVQVISAMAHHGY
LEQPGGEAMIEYIVQQCALPPEQESGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFL
RGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLIS
LVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPYSAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSID
ERPLSSSPLVRVKEEPPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGRPPSPPPTSTPEKCLS
VACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQL

--------------------------------------------------------------
>54880_54880_4_MROH1-HSF1_MROH1_chr8_145278133_ENST00000534366_HSF1_chr8_145532592_ENST00000528838_length(transcript)=3327nt_BP=1462nt
TGACTGGTCATAGCGTGCCGGGCATAGCGCTGGCAGGGCCGCCGGGAGCCAGCCCTCACTCAGCCAAGATGGGAGAAGAAGTTGTCCATG
TTCACACTGGGTGAAGGAAGCTGAAACCACAGACATGACTGAGTCCTCCATGAAGAAGCTGGCCTCCACCCTGCTGGACGCCATCACCGA
TAAGGACCCCCTGGTGCAGGAGCAGGTCTGCAGTGCCCTGTGCTCCCTCGGGGAGGCGCGGCCGGTGGAGACGCTCCGTGCCTGCGAGGA
GTATCTGCGGCAGCATGACAAGCTGGCACACCCATACCGAGCAGCGGTCCTGAGGGCCATGGAGAGGGTCCTGAGCAGTCGCGCCAGTGA
GCTGGACAAGGACACAGCCAGCACCATCATCCTCCTGGCCTCCAGCGAGATGACCAAGACGAAGGACCTGGTCTGGGACTGGCAGCAGGC
GGCGAGTGGCGTCCTGGTGGCCGTGGGAAGACAGTTCATCAGCAAGGTGATGGAGGAGCTGCTGCGCAGGCTGCACCCTGGGACCCTGCC
ACACTGCGCCGTGCTGCACACCCTCGCCAGCCTCTCGGTGGCCAACGCGTTCGGCGTAGTCCCCTTCCTGCCATCCGTCCTGAGCTCCCT
GCTGCCCGTGCTGGGCGTGGCCAAGCAGGACACGGTGCGCGTGGCCTTCTGCTCCGCTCTGCAGCGCTTCAGCGAGGGTGCCCTGGAGTA
CCTAGCCAACCTGGACCGAGCCCCAGACCCCACGGTCAGGAAGGACGCCTTTGCCACCGACATCTTCAGCGCCTACGATGTTCTCTTCCA
TCAGTGGCTGCAGAGTCGAGAAGCCAAGCTCCGTCTTGCCGTGGTGGAGGCTCTGGGGCCTATGAGCCATCTGCTGCCCAGTGAGAGGCT
GGAAGAGCAGCTGCCCAAGCTCCTCCCTGGGATTCTCGCCCTCTACAAGAAGCACGCAGAGACCTTCTACTTGTCCAAGAGCCTGGGCCA
GATCCTCGAGGCAGCTGTGAGTGTGGGCAGCCGCACACTGGAGACCCAGCTGGATGCCCTCTTGGCTGCACTGCACTCCCAGATCTGTGT
GCCTGTGGAGTCCTCAAGCCCCCTGGTGATGAGTAACCAGAAGGAGGTGCTGCGCTGCTTCACTGTGCTGGCCTGCAGCTCGCCTGACCG
CCTACTGGCCTTCCTGCTGCCCAGGCTGGACACCAGCAATGAGAGGACCCGCGTGGGCACCCTGCAGGTGGTCAGACATGTCATCAACTC
AGCTGCTGCTCAGATGGAAGATAAAAAGCCCTTTATCCTGTCTTCCATGAGGCTTCCTCTCCTGGACACCAACAGCAAGGTGAAGCGGGC
AGTGGTGCAGGTGATTAGCGCCATGGCCCACCACGGCTACCTGGAGCAGCCTGGAGGTGAGGCGATGATCGAGTACATCGTGCAGCAGTG
CGCGCTGCCCCCCGAGCAGGAGAGCGGGAACAGCTTCCACGTGTTCGACCAGGGCCAGTTTGCCAAGGAGGTGCTGCCCAAGTACTTCAA
GCACAACAACATGGCCAGCTTCGTGCGGCAGCTCAACATGTATGGCTTCCGGAAAGTGGTCCACATCGAGCAGGGCGGCCTGGTCAAGCC
AGAGAGAGACGACACGGAGTTCCAGCACCCATGCTTCCTGCGTGGCCAGGAGCAGCTCCTTGAGAACATCAAGAGGAAAGTGACCAGTGT
GTCCACCCTGAAGAGTGAAGACATAAAGATCCGCCAGGACAGCGTCACCAAGCTGCTGACGGACGTGCAGCTGATGAAGGGGAAGCAGGA
GTGCATGGACTCCAAGCTCCTGGCCATGAAGCATGAGAATGAGGCTCTGTGGCGGGAGGTGGCCAGCCTTCGGCAGAAGCATGCCCAGCA
ACAGAAAGTCGTCAACAAGCTCATTCAGTTCCTGATCTCACTGGTGCAGTCAAACCGGATCCTGGGGGTGAAGAGAAAGATCCCCCTGAT
GCTGAACGACAGTGGCTCAGCACATTCCATGCCCAAGTATAGCCGGCAGTTCTCCCTGGAGCACGTCCACGGCTCGGGCCCCTACTCGGC
CCCCTCCCCAGCCTACAGCAGCTCCAGCCTCTACGCCCCTGATGCTGTGGCCAGCTCTGGACCCATCATCTCCGACATCACCGAGCTGGC
TCCTGCCAGCCCCATGGCCTCCCCCGGCGGGAGCATAGACGAGAGGCCCCTATCCAGCAGCCCCCTGGTGCGTGTCAAGGAGGAGCCCCC
CAGCCCGCCTCAGAGCCCCCGGGTAGAGGAGGCGAGTCCCGGGCGCCCATCTTCCGTGGACACCCTCTTGTCCCCGACCGCCCTCATTGA
CTCCATCCTGCGGGAGAGTGAACCTGCCCCCGCCTCCGTCACAGCCCTCACGGACGCCAGGGGCCACACGGACACCGAGGGCCGGCCTCC
CTCCCCCCCGCCCACCTCCACCCCTGAAAAGTGCCTCAGCGTAGCCTGCCTGGACAAGAATGAGCTCAGTGACCACTTGGATGCTATGGA
CTCCAACCTGGATAACCTGCAGACCATGCTGAGCAGCCACGGCTTCAGCGTGGACACCAGTGCCCTGCTGGACCTGTTCAGCCCCTCGGT
GACCGTGCCCGACATGAGCCTGCCTGACCTTGACAGCAGCCTGGCCAGTATCCAAGAGCTCCTGTCTCCCCAGGAGCCCCCCAGGCCTCC
CGAGGCAGAGAACAGCAGCCCGGATTCAGGGAAGCAGCTGGTGCACTACACAGCGCAGCCGCTGTTCCTGCTGGACCCCGGCTCCGTGGA
CACCGGGAGCAACGACCTGCCGGTGCTGTTTGAGCTGGGAGAGGGCTCCTACTTCTCCGAAGGGGACGGCTTCGCCGAGGACCCCACCAT
CTCCCTGCTGACAGGCTCGGAGCCTCCCAAAGCCAAGGACCCCACTGTCTCCTAGAGGCCCCGGAGGAGCTGGGCCAGCCGCCCACCCCC
ACCCCCAGTGCAGGGCTGGTCTTGGGGAGGCAGGGCAGCCTCGCGGTCTTGGGCACTGGTGGGTCGGCCGCCATAGCCCCAGTAGGACAA
ACGGGCTCGGGTCTGGGCAGCACCTCTGGTCAGGAGGGTCACCCTGGCCTGCCAGTCTGCCTTCCCCCAACCCCGTGTCCTGTGGTTTGG
TTGGGGCTTCACAGCCACACCTGGACTGACCCTGCAGGTTGTTCATAGTCAGAATTGTATTTTGGATTTTTACACAACTGTCCCGTTCCC

>54880_54880_4_MROH1-HSF1_MROH1_chr8_145278133_ENST00000534366_HSF1_chr8_145532592_ENST00000528838_length(amino acids)=936AA_BP=0
MTESSMKKLASTLLDAITDKDPLVQEQVCSALCSLGEARPVETLRACEEYLRQHDKLAHPYRAAVLRAMERVLSSRASELDKDTASTIIL
LASSEMTKTKDLVWDWQQAASGVLVAVGRQFISKVMEELLRRLHPGTLPHCAVLHTLASLSVANAFGVVPFLPSVLSSLLPVLGVAKQDT
VRVAFCSALQRFSEGALEYLANLDRAPDPTVRKDAFATDIFSAYDVLFHQWLQSREAKLRLAVVEALGPMSHLLPSERLEEQLPKLLPGI
LALYKKHAETFYLSKSLGQILEAAVSVGSRTLETQLDALLAALHSQICVPVESSSPLVMSNQKEVLRCFTVLACSSPDRLLAFLLPRLDT
SNERTRVGTLQVVRHVINSAAAQMEDKKPFILSSMRLPLLDTNSKVKRAVVQVISAMAHHGYLEQPGGEAMIEYIVQQCALPPEQESGNS
FHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIR
QDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMP
KYSRQFSLEHVHGSGPYSAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEEPPSPPQSPRVEEA
SPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGRPPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLS
SHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTAQPLFLLDPGSVDTGSNDLPVLFE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MROH1-HSF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MROH1-HSF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for MROH1-HSF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource