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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MROH2B-MRPS30 (FusionGDB2 ID:54890)

Fusion Gene Summary for MROH2B-MRPS30

check button Fusion gene summary
Fusion gene informationFusion gene name: MROH2B-MRPS30
Fusion gene ID: 54890
HgeneTgene
Gene symbol

MROH2B

MRPS30

Gene ID

133558

10884

Gene namemaestro heat like repeat family member 2Bmitochondrial ribosomal protein S30
SynonymsHEATR7B2|SPIFMRP-S30|PAP|PDCD9|S30mt
Cytomap

5p13.1

5p12

Type of geneprotein-codingprotein-coding
Descriptionmaestro heat-like repeat-containing protein family member 2BHEAT repeat family member 7B2HEAT repeat family member B2HEAT repeat-containing protein 7B2sperm PKA-interacting factor39S ribosomal protein S30, mitochondrial28S ribosomal protein S30, mitochondrialmitochondrial large ribosomal subunit protein mL65mitochondrial large ribosomal subunit protein mS30programmed cell death 9
Modification date2020032020200313
UniProtAcc

Q7Z745

Q9NP92

Ensembl transtripts involved in fusion geneENST00000399564, ENST00000506092, 
ENST00000230914, ENST00000507110, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 6 X 3=90
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MROH2B [Title/Abstract] AND MRPS30 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMROH2B(41017952)-MRPS30(44813208), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MROH2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MRPS30 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-55-1596-01AMROH2Bchr5

41017952

-MRPS30chr5

44813208

+


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Fusion Gene ORF analysis for MROH2B-MRPS30

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000399564ENST00000230914MROH2Bchr5

41017952

-MRPS30chr5

44813208

+
5CDS-intronENST00000506092ENST00000230914MROH2Bchr5

41017952

-MRPS30chr5

44813208

+
In-frameENST00000399564ENST00000507110MROH2Bchr5

41017952

-MRPS30chr5

44813208

+
In-frameENST00000506092ENST00000507110MROH2Bchr5

41017952

-MRPS30chr5

44813208

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000506092MROH2Bchr541017952-ENST00000507110MRPS30chr544813208+2627184062306766
ENST00000399564MROH2Bchr541017952-ENST00000507110MRPS30chr544813208+4122333545138011116

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000506092ENST00000507110MROH2Bchr541017952-MRPS30chr544813208+0.0010452860.99895465
ENST00000399564ENST00000507110MROH2Bchr541017952-MRPS30chr544813208+0.000580430.99941957

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Fusion Genomic Features for MROH2B-MRPS30


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MROH2B-MRPS30


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:41017952/chr5:44813208)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MROH2B

Q7Z745

MRPS30

Q9NP92

FUNCTION: May play a role in the process of sperm capacitation. {ECO:0000250|UniProtKB:Q7M6Y6}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMROH2Bchr5:41017952chr5:44813208ENST00000399564-2842228_2639611586.0RepeatNote=HEAT 2
HgeneMROH2Bchr5:41017952chr5:44813208ENST00000399564-2842272_3099611586.0RepeatNote=HEAT 3
HgeneMROH2Bchr5:41017952chr5:44813208ENST00000399564-284228_659611586.0RepeatNote=HEAT 1
HgeneMROH2Bchr5:41017952chr5:44813208ENST00000399564-2842310_3469611586.0RepeatNote=HEAT 4
HgeneMROH2Bchr5:41017952chr5:44813208ENST00000399564-2842405_4459611586.0RepeatNote=HEAT 5
HgeneMROH2Bchr5:41017952chr5:44813208ENST00000399564-2842531_5699611586.0RepeatNote=HEAT 6
HgeneMROH2Bchr5:41017952chr5:44813208ENST00000399564-2842572_6119611586.0RepeatNote=HEAT 7
HgeneMROH2Bchr5:41017952chr5:44813208ENST00000399564-2842662_6999611586.0RepeatNote=HEAT 8
HgeneMROH2Bchr5:41017952chr5:44813208ENST00000399564-2842777_8199611586.0RepeatNote=HEAT 9

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMROH2Bchr5:41017952chr5:44813208ENST00000399564-28421021_10599611586.0RepeatNote=HEAT 11
HgeneMROH2Bchr5:41017952chr5:44813208ENST00000399564-28421112_11519611586.0RepeatNote=HEAT 12
HgeneMROH2Bchr5:41017952chr5:44813208ENST00000399564-28421157_11959611586.0RepeatNote=HEAT 13
HgeneMROH2Bchr5:41017952chr5:44813208ENST00000399564-28421258_12959611586.0RepeatNote=HEAT 14
HgeneMROH2Bchr5:41017952chr5:44813208ENST00000399564-28421363_14029611586.0RepeatNote=HEAT 15
HgeneMROH2Bchr5:41017952chr5:44813208ENST00000399564-2842964_10019611586.0RepeatNote=HEAT 10


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Fusion Gene Sequence for MROH2B-MRPS30


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>54890_54890_1_MROH2B-MRPS30_MROH2B_chr5_41017952_ENST00000399564_MRPS30_chr5_44813208_ENST00000507110_length(transcript)=4122nt_BP=3335nt
GAGTTCACCATAAAGCCTTTCCCAACATCAGGACAGTAAAGCAACTACTGAAAACCATTCCTGAATTTGTGATCAATGGACTCAAGTTTA
GGGAGAGGAGCACCTTTGGTCTGCAACAATGGTTTGAATCCCAGTCTCTAATTACTTCTTTCCCAAATACTCTGGTCACCAAAGGGACAA
TATTTGGTGAGATGCAGCCATTTTGTTGGTTAGCAGGAGTTCAGACGCAAGACAATGTCATAGTGGTAGAATACAGTATCAACTTCAACA
GCAAGCCCATCTCTGGAAGCTCCCAGACCATTGTGCCAATCAAGTGGAGGAGGCACTTTCATTTAGAGAGGCTTATGTGAACCTTATATG
AGAAACTTGCCAACCTGCCTCTTTGATTTTTTAGCCTTACTATTTCTAATACTTAGGTGCTATCTTTTAGAGACCCTGAAACAGCCAAGA
CATGACACTTAGTACAGAGGAATCCATAGAGATGTTTGGGGATATTAACCTCACTCTTGGCATGCTGAACAAGGAAGATATTGTTAACAA
GGAAGACATTTACAGTCATCTCACTTCTGTTATTCAGAATACTGACATCTTGGATGATGCAATTGTCCAACGATTGATTTATTATGCTTC
TAAGGATATGAGAGACAACAATATGCTCAGAGAAATCAGAATGCTAGCTGGTGAGGTTTTGGTGTCTCTTGCTGCACATGATTTCAACTC
TGTGATGTATGAAGTACAAAGTAACTTCAGGATCTTAGAGCTACCAGATGAATTCGTTGTGCTTGCCCTGGCTGAATTGGCAACCAGCTA
TGTGTCCCAGAGTATTCCTTTCATGATGATGACCCTGCTCACCATGCAAACCATGCTCAGGCTGGCCGAGGATGAAAGGATGAAGGGGAC
TTTCTGTATTGCCCTTGAGAAATTCAGCAAAGCCATTTACAAATATGTCAACCACTGGAGAGATTTTCCCTACCCCAGACTGGATGCCAA
CCGACTGTCTGACAAGATCTTCATGCTGTTCTGGTATATAATGGAGAAGTGGGCCCCTTTGGCCTCACCCATGCAGACTTTGAGCATCGT
TAAGGCCCACGGGCCCACGGTGAGCTTGCTGCTGCATCGGGAAGACTTCCGTGGATACGCCCTGGGCCAGGTGCCCTGGCTCCTGAACCA
GTATAAAGACAAAGAGATTGATTTCCATGTCACTCAGAGCCTAAAACAAATACTGACTGCAGCAGTTCTTTATGACATTGGCCTTCCAAG
GAGCTTGAGAAGATCCATCTTTATCAATTTACTCCAGCAGATCTGCAGAGCTCCAGAGCCTCCAGTAAAGGAAAATGAAATGAAAGCTTC
AAGCTGTTTTCTCATTCTAGCCCATTCCAATCCTGGAGAGCTGATGGAATTTTTTGATGAACAAGTAAGAAGTAATAATGAAGCCATTCG
AGTGGGAATCTTGACTTTGTTAAGATTGGCTGTCAATGCTGATGAGCCCAGGTTGAGGGATCACATCATTTCAATAGAAAGAACAGTCAA
AATCGTCATGGGTGATCTCAGTACAAAAGTAAGAAATTCTGTTCTTCTCCTCATCCAAACCATGTGTGAAAAGTCCTATATTGAAGCTCG
GGAAGGATGGCCATTGATTGATTATGTCTTCTCCCAGTTTGCAACGTTGAACAGGAATCTGGAGAAACCAGTGAAAACTAACTTTCATGA
GAATGAAAAGGAAGAGGAATCTGTCCGAGAAACAAGCCTTGAGGTCTTAAAAACCCTGGACCCACTGGTCATTGGAATGCCTCAGGTGCT
ATGGCCAAGGATCCTGACTTTTGTGGTACCTGCAGAATACACAGAAGCTCTGGAGCCCCTGTTTAGTATCATCAGAATTCTGATTATGGC
AGAGGAGAAGAAGCAGCACAGTGCCAAGGAGTCGACAGCACTTGTCGTCTCTACAGGAGCTGTGAAACTTCCTTCACCACAGCAGCTACT
GGCCAGACTTCTGGTAATATCTATGCCTGCCAGTTTAGGGGAGTTACGTGGGGCTGGTGCAATAGGGCTTTTGAAGATACTGCCTGAGAT
AATTCACCCAAAATTGGTAGACCTATGGAAAACACGTTTACCTGAGCTTCTGCAGCCTCTGGAAGGAAAGAACATCAGTACCGTTCTATG
GGAAACCATGCTGCTTCAGTTGCTCAAAGAATCCTTATGGAAGATCAGTGATGTGGCCTGGACCATTCAGCTGACTCAGGATTTCAAACA
GCAAATGGGCAGTTACAGCAATAACTCCACTGAGAAGAAATTCCTTTGGAAAGCCTTGGGAACCACCTTAGCATGCTGCCAAGATTCAGA
CTTTGTAAACTCACAGATTAAGGAGTTTCTGACTGCTCCCAACCAACTGGGGGATCAAAGACAGGGAATAACATCTATTTTAGGATACTG
TGCCGAGAACCATTTGGATATTGTTTTAAAAGTTCTTAAAACATTCCAAAATCAGGAAAAGTTTTTCATGAATCGATGTAAGAGCCTTTT
TTCTGGGAAAAAGAGCCTGACCAAGACAGATGTCATGGTCATCTATGGAGCAGTGGCCCTCCATGCTCCCAAGAAGCAACTTCTCTCCAG
ACTTAATCAAGATATCATATCCCAAGTCCTGTCTCTTCATGGCCAGTGCTCTCAGGTTCTGGGCATGTCTGTGATGAACAAGGACATGGA
TCTGCAAATGAGTTTCACAAGAAGCATCACTGAGATTGGCATTGCTGTCCAAGATGCTGAGGATCAGGGGTTCCAGTTTTCCTACAAGGA
GATGCTGATTGGTTACATGCTGGACTTCATTAGAGACGAGCCCCTGGATTCCTTAGCTAGCCCTATTCGGTGGAAAGCCTTAATCGCCAT
TAGGTATCTCAGTAAACTGAAACCTCAGCTCTCACTACAAGACCACCTTAACATTCTTGAGGAGAATATTCGGAGGCTGCTGCCCCTTCC
ACCTCTGGAAAATCTGAAAAGTGAAGGCCAGACAGACAAGGACAAGGAGCACATTCAATTTCTCTATGAACGATCCATGGACGCCCTAGG
AAAACTTCTGAAGACCATGATGTGGGATAATGTGAATGCAGAGGACTGTCAAGAAATGTTTAATCTTCTCCAAATGTGGCTTGTTTCACA
AAAAGAGTGGGAAAGAGAAAGAGCCTTCCAGATCACTGCGAAAGTGCTGACAAATGATATTGAGGCACCAGAGAACTTTAAAATTGGTTC
ACTGCTTGGACTTCTGGCTCCTCACTCCTGTGATACCCTGCCCACCATCCGTCAGGCGGCTGCTAGCTCAACTATTGGTCTGTTCTATAT
AAAAGGCTCAAAAACTGCAGATCCTTGCTGTTACGGTCACACCCAGTTTCATCTGTTACCTGACAAATTAAGAAGGGAAAGGCTTTTGAG
ACAAAACTGTGCTGATCAGATAGAAGTTGTTTTTAGAGCTAATGCTATTGCAAGCCTTTTTGCTTGGACTGGAGCACAAGCTATGTATCA
AGGATTCTGGAGTGAAGCAGATGTTACTCGACCTTTTGTCTCCCAGGCTGTGATCACAGATGGAAAATACTTTTCCTTTTTCTGCTACCA
GCTAAATACTTTGGCACTGACTACACAAGCTGATCAAAATAACCCTCGTAAAAATATATGTTGGGGTACACAAAGTAAGCCTCTTTATGA
AACAATTGAGGATAATGATGTGAAAGGTTTTAATGATGATGTTCTACTTCAGATAGTTCACTTTCTACTGAATAGACCAAAAGAAGAAAA
ATCACAGCTGTTGGAAAACTGAAAAAGCATATTTGATTGAGAACTGTGGGAATATTTAAATTTTACTGAAGGAACAATAATGATGAGATT
TGTAACTGTCAACTATTAAATACATTGATTTTTGAGACAAATATTTCTTATGTCAACCTGTTATTAGATCTCTTACTCTGCTCAAATTCA
TCACTGAAAGATTTAATTTTAGTTACCTTTTGTTGATTTAAAAATAATTGCATTTGTATATTGCTAACTGATAAGACAAATTGAGTTATT

>54890_54890_1_MROH2B-MRPS30_MROH2B_chr5_41017952_ENST00000399564_MRPS30_chr5_44813208_ENST00000507110_length(amino acids)=1116AA_BP=951
MTLSTEESIEMFGDINLTLGMLNKEDIVNKEDIYSHLTSVIQNTDILDDAIVQRLIYYASKDMRDNNMLREIRMLAGEVLVSLAAHDFNS
VMYEVQSNFRILELPDEFVVLALAELATSYVSQSIPFMMMTLLTMQTMLRLAEDERMKGTFCIALEKFSKAIYKYVNHWRDFPYPRLDAN
RLSDKIFMLFWYIMEKWAPLASPMQTLSIVKAHGPTVSLLLHREDFRGYALGQVPWLLNQYKDKEIDFHVTQSLKQILTAAVLYDIGLPR
SLRRSIFINLLQQICRAPEPPVKENEMKASSCFLILAHSNPGELMEFFDEQVRSNNEAIRVGILTLLRLAVNADEPRLRDHIISIERTVK
IVMGDLSTKVRNSVLLLIQTMCEKSYIEAREGWPLIDYVFSQFATLNRNLEKPVKTNFHENEKEEESVRETSLEVLKTLDPLVIGMPQVL
WPRILTFVVPAEYTEALEPLFSIIRILIMAEEKKQHSAKESTALVVSTGAVKLPSPQQLLARLLVISMPASLGELRGAGAIGLLKILPEI
IHPKLVDLWKTRLPELLQPLEGKNISTVLWETMLLQLLKESLWKISDVAWTIQLTQDFKQQMGSYSNNSTEKKFLWKALGTTLACCQDSD
FVNSQIKEFLTAPNQLGDQRQGITSILGYCAENHLDIVLKVLKTFQNQEKFFMNRCKSLFSGKKSLTKTDVMVIYGAVALHAPKKQLLSR
LNQDIISQVLSLHGQCSQVLGMSVMNKDMDLQMSFTRSITEIGIAVQDAEDQGFQFSYKEMLIGYMLDFIRDEPLDSLASPIRWKALIAI
RYLSKLKPQLSLQDHLNILEENIRRLLPLPPLENLKSEGQTDKDKEHIQFLYERSMDALGKLLKTMMWDNVNAEDCQEMFNLLQMWLVSQ
KEWERERAFQITAKVLTNDIEAPENFKIGSLLGLLAPHSCDTLPTIRQAAASSTIGLFYIKGSKTADPCCYGHTQFHLLPDKLRRERLLR
QNCADQIEVVFRANAIASLFAWTGAQAMYQGFWSEADVTRPFVSQAVITDGKYFSFFCYQLNTLALTTQADQNNPRKNICWGTQSKPLYE

--------------------------------------------------------------
>54890_54890_2_MROH2B-MRPS30_MROH2B_chr5_41017952_ENST00000506092_MRPS30_chr5_44813208_ENST00000507110_length(transcript)=2627nt_BP=1840nt
ATTTGTTTGCTGCCTGTACAGACTTTGAGCATCGTTAAGGCCCACGGGCCCACGGTGAGCTTGCTGCTGCATCGGGAAGACTTCCGTGGA
TACGCCCTGGGCCAGGTGCCCTGGCTCCTGAACCAGTATAAAGACAAAGAGATTGATTTCCATGTCACTCAGTTTGCAACGTTGAACAGG
AATCTGGAGAAACCAGTGAAAACTAACTTTCATGAGAATGAAAAGGAAGAGGAATCTGTCCGAGAAACAAGCCTTGAGGTCTTAAAAACC
CTGGACCCACTGGTCATTGGAATGCCTCAGGTGCTATGGCCAAGGATCCTGACTTTTGTGGTACCTGCAGAATACACAGAAGCTCTGGAG
CCCCTGTTTAGTATCATCAGAATTCTGATTATGGCAGAGGAGAAGAAGCAGCACAGTGCCAAGGAGTCGACAGCACTTGTCGTCTCTACA
GGAGCTGTGAAACTTCCTTCACCACAGCAGCTACTGGCCAGACTTCTGGTAATATCTATGCCTGCCAGTTTAGGGGAGTTACGTGGGGCT
GGTGCAATAGGGCTTTTGAAGATACTGCCTGAGATAATTCACCCAAAATTGGTAGACCTATGGAAAACACGTTTACCTGAGCTTCTGCAG
CCTCTGGAAGGAAAGAACATCAGTACCGTTCTATGGGAAACCATGCTGCTTCAGTTGCTCAAAGAATCCTTATGGAAGATCAGTGATGTG
GCCTGGACCATTCAGCTGACTCAGGATTTCAAACAGCAAATGGGCAGTTACAGCAATAACTCCACTGAGAAGAAATTCCTTTGGAAAGCC
TTGGGAACCACCTTAGCATGCTGCCAAGATTCAGACTTTGTAAACTCACAGATTAAGGAGTTTCTGACTGCTCCCAACCAACTGGGGGAT
CAAAGACAGGGAATAACATCTATTTTAGGATACTGTGCCGAGAACCATTTGGATATTGTTTTAAAAGTTCTTAAAACATTCCAAAATCAG
GAAAAGTTTTTCATGAATCGATGTAAGAGCCTTTTTTCTGGGAAAAAGAGCCTGACCAAGACAGATGTCATGGTCATCTATGGAGCAGTG
GCCCTCCATGCTCCCAAGAAGCAACTTCTCTCCAGACTTAATCAAGATATCATATCCCAAGTCCTGTCTCTTCATGGCCAGTGCTCTCAG
GTTCTGGGCATGTCTGTGATGAACAAGGACATGGATCTGCAAATGAGTTTCACAAGAAGCATCACTGAGATTGGCATTGCTGTCCAAGAT
GCTGAGGATCAGGGGTTCCAGTTTTCCTACAAGGAGATGCTGATTGGTTACATGCTGGACTTCATTAGAGACGAGCCCCTGGATTCCTTA
GCTAGCCCTATTCGGTGGAAAGCCTTAATCGCCATTAGGTATCTCAGTAAACTGAAACCTCAGCTCTCACTACAAGACCACCTTAACATT
CTTGAGGAGAATATTCGGAGGCTGCTGCCCCTTCCACCTCTGGAAAATCTGAAAAGTGAAGGCCAGACAGACAAGGACAAGGAGCACATT
CAATTTCTCTATGAACGATCCATGGACGCCCTAGGAAAACTTCTGAAGACCATGATGTGGGATAATGTGAATGCAGAGGACTGTCAAGAA
ATGTTTAATCTTCTCCAAATGTGGCTTGTTTCACAAAAAGAGTGGGAAAGAGAAAGAGCCTTCCAGATCACTGCGAAAGTGCTGACAAAT
GATATTGAGGCACCAGAGAACTTTAAAATTGGTTCACTGCTTGGACTTCTGGCTCCTCACTCCTGTGATACCCTGCCCACCATCCGTCAG
GCGGCTGCTAGCTCAACTATTGGTCTGTTCTATATAAAAGGCTCAAAAACTGCAGATCCTTGCTGTTACGGTCACACCCAGTTTCATCTG
TTACCTGACAAATTAAGAAGGGAAAGGCTTTTGAGACAAAACTGTGCTGATCAGATAGAAGTTGTTTTTAGAGCTAATGCTATTGCAAGC
CTTTTTGCTTGGACTGGAGCACAAGCTATGTATCAAGGATTCTGGAGTGAAGCAGATGTTACTCGACCTTTTGTCTCCCAGGCTGTGATC
ACAGATGGAAAATACTTTTCCTTTTTCTGCTACCAGCTAAATACTTTGGCACTGACTACACAAGCTGATCAAAATAACCCTCGTAAAAAT
ATATGTTGGGGTACACAAAGTAAGCCTCTTTATGAAACAATTGAGGATAATGATGTGAAAGGTTTTAATGATGATGTTCTACTTCAGATA
GTTCACTTTCTACTGAATAGACCAAAAGAAGAAAAATCACAGCTGTTGGAAAACTGAAAAAGCATATTTGATTGAGAACTGTGGGAATAT
TTAAATTTTACTGAAGGAACAATAATGATGAGATTTGTAACTGTCAACTATTAAATACATTGATTTTTGAGACAAATATTTCTTATGTCA
ACCTGTTATTAGATCTCTTACTCTGCTCAAATTCATCACTGAAAGATTTAATTTTAGTTACCTTTTGTTGATTTAAAAATAATTGCATTT
GTATATTGCTAACTGATAAGACAAATTGAGTTATTGAGCTATTAAATGCACATTTTAATATAAATGCAGAAATCCCAAATAAAATGCTAA

>54890_54890_2_MROH2B-MRPS30_MROH2B_chr5_41017952_ENST00000506092_MRPS30_chr5_44813208_ENST00000507110_length(amino acids)=766AA_BP=601
MLPVQTLSIVKAHGPTVSLLLHREDFRGYALGQVPWLLNQYKDKEIDFHVTQFATLNRNLEKPVKTNFHENEKEEESVRETSLEVLKTLD
PLVIGMPQVLWPRILTFVVPAEYTEALEPLFSIIRILIMAEEKKQHSAKESTALVVSTGAVKLPSPQQLLARLLVISMPASLGELRGAGA
IGLLKILPEIIHPKLVDLWKTRLPELLQPLEGKNISTVLWETMLLQLLKESLWKISDVAWTIQLTQDFKQQMGSYSNNSTEKKFLWKALG
TTLACCQDSDFVNSQIKEFLTAPNQLGDQRQGITSILGYCAENHLDIVLKVLKTFQNQEKFFMNRCKSLFSGKKSLTKTDVMVIYGAVAL
HAPKKQLLSRLNQDIISQVLSLHGQCSQVLGMSVMNKDMDLQMSFTRSITEIGIAVQDAEDQGFQFSYKEMLIGYMLDFIRDEPLDSLAS
PIRWKALIAIRYLSKLKPQLSLQDHLNILEENIRRLLPLPPLENLKSEGQTDKDKEHIQFLYERSMDALGKLLKTMMWDNVNAEDCQEMF
NLLQMWLVSQKEWERERAFQITAKVLTNDIEAPENFKIGSLLGLLAPHSCDTLPTIRQAAASSTIGLFYIKGSKTADPCCYGHTQFHLLP
DKLRRERLLRQNCADQIEVVFRANAIASLFAWTGAQAMYQGFWSEADVTRPFVSQAVITDGKYFSFFCYQLNTLALTTQADQNNPRKNIC

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Fusion Gene PPI Analysis for MROH2B-MRPS30


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MROH2B-MRPS30


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MROH2B-MRPS30


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource