FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MRPL23-MAP3K13 (FusionGDB2 ID:54966)

Fusion Gene Summary for MRPL23-MAP3K13

check button Fusion gene summary
Fusion gene informationFusion gene name: MRPL23-MAP3K13
Fusion gene ID: 54966
HgeneTgene
Gene symbol

MRPL23

MAP3K13

Gene ID

6150

9175

Gene namemitochondrial ribosomal protein L23mitogen-activated protein kinase kinase kinase 13
SynonymsL23MRP|RPL23|RPL23LLZK|MEKK13|MLK
Cytomap

11p15.5

3q27.2

Type of geneprotein-codingprotein-coding
Description39S ribosomal protein L23, mitochondrialL23 mitochondrial-related proteinL23mtMRP-L23mitochondrial large ribosomal subunit protein uL23mribosomal protein related to L23 (mitochondrial)mitogen-activated protein kinase kinase kinase 13leucine zipper-bearing kinasemixed lineage kinase
Modification date2020032020200313
UniProtAcc

Q16540

O43283

Ensembl transtripts involved in fusion geneENST00000381514, ENST00000381519, 
ENST00000397294, ENST00000397297, 
ENST00000397298, ENST00000486931, 
ENST00000265026, ENST00000424227, 
ENST00000438798, ENST00000443863, 
ENST00000446828, ENST00000448876, 
ENST00000454237, ENST00000535426, 
Fusion gene scores* DoF score13 X 13 X 2=33812 X 14 X 9=1512
# samples 1314
** MAII scorelog2(13/338*10)=-1.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1512*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MRPL23 [Title/Abstract] AND MAP3K13 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMRPL23(2018165)-MAP3K13(185136444), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAP3K13

GO:0000186

activation of MAPKK activity

11726277

TgeneMAP3K13

GO:0006468

protein phosphorylation

9353328|11726277

TgeneMAP3K13

GO:0007254

JNK cascade

9353328|11726277

TgeneMAP3K13

GO:0046777

protein autophosphorylation

9353328

TgeneMAP3K13

GO:0051092

positive regulation of NF-kappaB transcription factor activity

12492477


check buttonFusion gene breakpoints across MRPL23 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MAP3K13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABC004532MRPL23chr11

2018165

+MAP3K13chr3

185136444

-


Top

Fusion Gene ORF analysis for MRPL23-MAP3K13

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000381514ENST00000265026MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000381514ENST00000424227MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000381514ENST00000438798MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000381514ENST00000443863MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000381514ENST00000446828MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000381514ENST00000448876MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000381514ENST00000454237MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000381514ENST00000535426MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000381519ENST00000265026MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000381519ENST00000424227MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000381519ENST00000438798MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000381519ENST00000443863MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000381519ENST00000446828MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000381519ENST00000448876MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000381519ENST00000454237MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000381519ENST00000535426MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000397294ENST00000265026MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000397294ENST00000424227MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000397294ENST00000438798MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000397294ENST00000443863MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000397294ENST00000446828MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000397294ENST00000448876MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000397294ENST00000454237MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000397294ENST00000535426MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000397297ENST00000265026MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000397297ENST00000424227MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000397297ENST00000438798MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000397297ENST00000443863MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000397297ENST00000446828MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000397297ENST00000448876MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000397297ENST00000454237MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000397297ENST00000535426MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000397298ENST00000265026MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000397298ENST00000424227MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000397298ENST00000438798MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000397298ENST00000443863MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000397298ENST00000446828MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000397298ENST00000448876MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000397298ENST00000454237MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000397298ENST00000535426MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000486931ENST00000265026MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000486931ENST00000424227MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000486931ENST00000438798MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000486931ENST00000443863MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000486931ENST00000446828MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000486931ENST00000448876MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000486931ENST00000454237MRPL23chr11

2018165

+MAP3K13chr3

185136444

-
intron-intronENST00000486931ENST00000535426MRPL23chr11

2018165

+MAP3K13chr3

185136444

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for MRPL23-MAP3K13


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for MRPL23-MAP3K13


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:2018165/:185136444)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MRPL23

Q16540

MAP3K13

O43283

FUNCTION: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for MRPL23-MAP3K13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for MRPL23-MAP3K13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MRPL23-MAP3K13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for MRPL23-MAP3K13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource