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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MRPL30-EIF5B (FusionGDB2 ID:54992)

Fusion Gene Summary for MRPL30-EIF5B

check button Fusion gene summary
Fusion gene informationFusion gene name: MRPL30-EIF5B
Fusion gene ID: 54992
HgeneTgene
Gene symbol

MRPL30

EIF5B

Gene ID

51263

9669

Gene namemitochondrial ribosomal protein L30eukaryotic translation initiation factor 5B
SynonymsL28MT|L30MT|MRP-L28|MRP-L30|MRPL28|MRPL28M|RPML28IF2
Cytomap

2q11.2

2q11.2

Type of geneprotein-codingprotein-coding
Description39S ribosomal protein L30, mitochondrial39S ribosomal protein L28, mitochondrialmitochondrial large ribosomal subunit protein uL30meukaryotic translation initiation factor 5BeIF-5Btranslation initiation factor IF-2translation initiation factor IF2
Modification date2020031320200313
UniProtAcc

Q8TCC3

O60841

Ensembl transtripts involved in fusion geneENST00000338148, ENST00000409145, 
ENST00000410042, ENST00000465432, 
ENST00000289371, 
Fusion gene scores* DoF score9 X 5 X 8=36017 X 18 X 5=1530
# samples 921
** MAII scorelog2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(21/1530*10)=-2.86507041991389
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MRPL30 [Title/Abstract] AND EIF5B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMRPL30(99804720)-EIF5B(99980734), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneEIF5B

GO:0006446

regulation of translational initiation

10432305


check buttonFusion gene breakpoints across MRPL30 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EIF5B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GN-01AMRPL30chr2

99804720

+EIF5Bchr2

99980734

+


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Fusion Gene ORF analysis for MRPL30-EIF5B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000338148ENST00000289371MRPL30chr2

99804720

+EIF5Bchr2

99980734

+
In-frameENST00000409145ENST00000289371MRPL30chr2

99804720

+EIF5Bchr2

99980734

+
In-frameENST00000410042ENST00000289371MRPL30chr2

99804720

+EIF5Bchr2

99980734

+
intron-3CDSENST00000465432ENST00000289371MRPL30chr2

99804720

+EIF5Bchr2

99980734

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000410042MRPL30chr299804720+ENST00000289371EIF5Bchr299980734+47773392072864885
ENST00000338148MRPL30chr299804720+ENST00000289371EIF5Bchr299980734+47683301982855885
ENST00000409145MRPL30chr299804720+ENST00000289371EIF5Bchr299980734+4661223912748885

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000410042ENST00000289371MRPL30chr299804720+EIF5Bchr299980734+0.0001168350.9998832
ENST00000338148ENST00000289371MRPL30chr299804720+EIF5Bchr299980734+0.0001099530.9998901
ENST00000409145ENST00000289371MRPL30chr299804720+EIF5Bchr299980734+0.0001076810.99989235

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Fusion Genomic Features for MRPL30-EIF5B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MRPL30-EIF5B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:99804720/chr2:99980734)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MRPL30

Q8TCC3

EIF5B

O60841

FUNCTION: Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes. {ECO:0000250|UniProtKB:P39730}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEIF5Bchr2:99804720chr2:99980734ENST00000289371424491_4963791221.0Compositional biasNote=Poly-Glu
TgeneEIF5Bchr2:99804720chr2:99980734ENST00000289371424529_5673791221.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneEIF5Bchr2:99804720chr2:99980734ENST00000289371424629_8463791221.0Domaintr-type G
TgeneEIF5Bchr2:99804720chr2:99980734ENST00000289371424638_6453791221.0RegionG1
TgeneEIF5Bchr2:99804720chr2:99980734ENST00000289371424663_6673791221.0RegionG2
TgeneEIF5Bchr2:99804720chr2:99980734ENST00000289371424702_7053791221.0RegionG3
TgeneEIF5Bchr2:99804720chr2:99980734ENST00000289371424756_7593791221.0RegionG4
TgeneEIF5Bchr2:99804720chr2:99980734ENST00000289371424824_8263791221.0RegionG5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEIF5Bchr2:99804720chr2:99980734ENST00000289371424138_1423791221.0Compositional biasNote=Poly-Asp
TgeneEIF5Bchr2:99804720chr2:99980734ENST00000289371424313_3223791221.0Compositional biasNote=Poly-Lys
TgeneEIF5Bchr2:99804720chr2:99980734ENST00000289371424353_3563791221.0Compositional biasNote=Poly-Glu
TgeneEIF5Bchr2:99804720chr2:99980734ENST00000289371424361_3643791221.0Compositional biasNote=Poly-Glu
TgeneEIF5Bchr2:99804720chr2:99980734ENST0000028937142439_503791221.0Compositional biasNote=Poly-Lys
TgeneEIF5Bchr2:99804720chr2:99980734ENST0000028937142494_993791221.0Compositional biasNote=Poly-Lys


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Fusion Gene Sequence for MRPL30-EIF5B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>54992_54992_1_MRPL30-EIF5B_MRPL30_chr2_99804720_ENST00000338148_EIF5B_chr2_99980734_ENST00000289371_length(transcript)=4768nt_BP=330nt
CTCTTTCTAGGGACTTTCCTGAGTGGGAGGGATTTCGCCGGAACAAAAATGCCTCAGTTTGGAGGTCGCGCTCACTGCGACGGCAGGCTT
TGAGTGTAGCACTTGGTAGTTCTTCCTCTGCTCTGCTTCCCTTCGGAGGAAAATTTCAGGCTGAAGGTTTAGCGGGTGCCGCCTCTAAAG
AGAGCAATCACTACACTTATGGCTGGGATTTTGCGCTTAGTAGTTCAATGGCCCCCAGGCAGACTACAGACTGTGACAAAAGGTGTGGAG
TCTCTTATTTGTACAGATTGGATTCGTCACAAATTCACCAGATCAAGAATTCCAGAAAAAGAACGATTGGAACAAGAAAAAAGAGAAAGG
AAAAAGCAAAAAGAAAAAGAAAGAAAAGAACGCTTGAAAAAAGAAGGGAAACTTTTAACTAAATCCCAGAGAGAAGCCAGAGCCAGAGCC
GAAGCTACTCTTAAACTGCTACAAGCTCAGGGTGTTGAAGTGCCATCAAAAGACTCTTTGCCAAAGAAGAGGCCAATTTATGAAGATAAA
AAGAGGAAAAAAATACCACAGCAGCTAGAAAGTAAAGAAGTGTCTGAATCAATGGAATTATGTGCTGCTGTAGAAGTTATGGAACAAGGA
GTACCAGAAAAGGAAGAGACACCACCTCCTGTTGAACCAGAAGAAGAAGAAGATACTGAGGATGCTGGATTGGATGATTGGGAAGCTATG
GCCAGTGATGAGGAGACAGAAAAAGTAGAAGGAAACAAAGTTCATATAGAAGTAAAAGAAAACCCTGAAGAGGAGGAGGAGGAGGAAGAA
GAGGAAGAAGAAGATGAAGAAAGTGAAGAAGAGGAGGAAGAGGAGGGAGAAAGTGAAGGCAGTGAAGGTGATGAGGAAGATGAAAAGGTG
TCAGATGAGAAGGATTCAGGGAAGACATTAGATAAAAAGCCAAGTAAAGAAATGAGCTCAGATTCTGAATATGACTCTGATGATGATCGG
ACTAAAGAAGAAAGGGCTTATGACAAAGCAAAACGGAGGATTGAGAAACGGCGACTTGAACATAGTAAAAATGTAAACACCGAAAAGCTA
AGAGCCCCTATTATCTGCGTACTTGGGCATGTGGACACAGGGAAGACAAAAATTCTAGATAAGCTCCGTCACACACATGTACAAGATGGT
GAAGCAGGTGGTATCACACAACAAATTGGGGCCACCAATGTTCCTCTTGAAGCTATTAATGAACAGACTAAGATGATTAAAAATTTTGAT
AGAGAGAATGTACGGATTCCAGGAATGCTAATTATTGATACTCCTGGGCATGAATCTTTCAGTAATCTGAGAAATAGAGGAAGCTCTCTT
TGTGACATTGCCATTTTAGTTGTTGATATTATGCATGGTTTGGAGCCCCAGACAATTGAGTCTATCAACCTTCTCAAATCTAAAAAATGT
CCCTTCATTGTTGCACTCAATAAGATTGATAGGTTATATGATTGGAAAAAGAGTCCTGACTCTGATGTGGCTGCTACTTTAAAGAAGCAG
AAAAAGAATACAAAAGATGAATTTGAGGAGCGAGCAAAGGCTATTATTGTAGAATTTGCACAGCAGGGTTTGAATGCTGCTTTGTTTTAT
GAGAATAAAGATCCCCGCACTTTTGTGTCTTTGGTACCTACCTCTGCACATACTGGTGATGGCATGGGAAGTCTGATCTACCTTCTTGTA
GAGTTAACTCAGACCATGTTGAGCAAGAGACTTGCACACTGTGAAGAGCTGAGAGCACAGGTGATGGAGGTTAAAGCTCTCCCGGGGATG
GGCACCACTATAGATGTCATCTTGATCAATGGGCGTTTGAAGGAAGGAGATACAATCATTGTTCCTGGAGTAGAAGGGCCCATTGTAACT
CAGATTCGAGGCCTCCTGTTACCTCCTCCTATGAAGGAATTACGAGTGAAGAACCAGTATGAAAAGCATAAAGAAGTAGAAGCAGCTCAG
GGGGTAAAGATTCTTGGAAAAGACCTGGAGAAAACATTGGCTGGTTTACCCCTCCTTGTGGCTTATAAAGAAGATGAAATCCCTGTTCTT
AAAGATGAATTGATCCATGAGTTAAAGCAGACACTAAATGCTATCAAATTAGAAGAAAAAGGAGTCTATGTCCAGGCATCTACACTGGGT
TCTTTGGAAGCTCTACTGGAATTTCTGAAAACATCAGAAGTGCCCTATGCAGGAATTAACATTGGCCCAGTGCATAAAAAAGATGTTATG
AAGGCTTCAGTGATGTTGGAACATGACCCTCAGTATGCAGTAATTTTGGCCTTCGATGTGAGAATTGAACGAGATGCACAAGAAATGGCT
GATAGTTTAGGAGTTAGAATTTTTAGTGCAGAAATTATTTATCATTTATTTGATGCCTTTACAAAATATAGACAAGACTACAAGAAACAG
AAACAAGAAGAATTTAAGCACATAGCAGTATTTCCCTGCAAGATAAAAATCCTCCCTCAGTACATTTTTAATTCTCGAGATCCGATAGTG
ATGGGGGTGACGGTGGAAGCAGGTCAGGTGAAACAGGGGACACCCATGTGTGTCCCAAGCAAAAATTTTGTTGACATCGGAATAGTAACA
AGTATTGAAATAAACCATAAACAAGTGGATGTTGCAAAAAAAGGACAAGAAGTTTGTGTAAAAATAGAACCTATCCCTGGTGAGTCACCC
AAAATGTTTGGAAGACATTTTGAAGCTACAGATATTCTTGTTAGTAAGATCAGCCGGCAGTCCATTGATGCACTCAAAGACTGGTTCAGA
GATGAAATGCAGAAGAGTGACTGGCAGCTTATTGTGGAGCTGAAGAAAGTATTTGAAATCATCTAATTTTTTCACATGGAGCAGGAACTG
GAGTAAATGCAATACTGTGTTGTAATATCCCAACAAAAATCAGACAAAAAATGGAACAGACGTATTTGGACACTGATGGACTTAAGTATG
GAAGGAAGAAAAATAGGTGTATAAAATGTTTTCCATGAGAAACCAAGAAACTTACACTGGTTTGACAGTGGTCAGTTACATGTCCCCACA
GTTCCAATGTGCCTGTTCACTCACCTCTCCCTTCCCCAACCCTTCTCTACTTGGCTGCTGTTTTAAAGTTTGCCCTTCCCCAAATTTGGA
TTTTTATTACAGATCTAAAGCTCTTTCGATTTTATACTGATTAAATCAGTACTGCAGTATTTGATTAACCAAGCTTCTGCAGATTTTGTG
ATTCTTGGGACTTTTTTGACGTAAGAAATACTTCTTTATTTATGCATATTCTTCCCACAGTGATTTTTCCAGCATTCTTCTGCCATATGC
CTTTAGGGCTTTTATAAAATAGAAAATTAGGCATTCTGATATTTCTTTAGCTGCTTTGTGTGAAACCATGGTGTAAAAGCACAGCTGGCT
GCTTTTTACTGCTTGTGTAGTCACGAGTCCATTGTAATCATCACAATTCTAAACCAAACTACCAATAAAGAAAACAGACATCCACCAGTA
AGCAAGCTCTGTTAGGCTTCCATGTTAGTGTAGCTTCTCTCCCACAAGTTGTCCTCCTAGGACAAGAATTATCTTACAAACTAAACTATC
ATCACACTACCTTGTATGCCAGCACCTGGTAACAGTAGAGATTTTTATACATTAATCTTGATCTGTTTTAATCTTGATCTGTTTTAGTAG
AGATTTTTATACATTAATCTTGATCTGTTTTAATCTTGATCTGTTTTGTCCTAGAAAATTCCATCATACACACATTTCCTGATATTTGGG
CTTAGTGCTTCTAAATTGTTGCAGACACAAAACTTAATGATTCATTCGTAGTAGTAATCTGTAGCTAGTTTTAGGGTTTTGCTGAAGTCA
GTGTGGGGTGTTTGTTTGAGGAAAAAGTTCCAAATATCCACTAGCATAGAATTTTAAACTATTTTTATTTTAAAGTTATGGCATAACATA
TAACATAAAAATATTTTATATACGTTTGAAAAATCTATACCGTTCTTTTTTATCATCAAAGTTTCTCAATGGCCAGTAGAAGCAAAAAGA
CAACACCACCTCTGATCTACGGGACATAATGTTCCCAGGAAAAAAATCTTCAAGTGGGTGTGAGGGTGTTTCTAATTCAAAATATGTAGA
TTTCTCCGCATGGAAGAAGTAGTAAAGATTTTCTTAACATGCTCCTGTGTTCATGCTTGGAGACAAGAATAAGATGGTTTAGAAGCTTTA
CCCTTTCTTGGAACAAGTAGAATCCCGGTCTGAGACCTCTCAGGAATTTCAGAGCTTAGCAGTCTGGCCTGGAGGTTTTTCAGCCTTTTA
GTATAATAAACAGTAGTTGCTTCCTAGAGTTGAGTTTTTAAGGATTCACAAAAAGGAGCCTGTACAAAATATACATACAGTTCTTTATTA
AACAACTGTAAACACTTCACTGTAAAAATCCATAAAACTTTATAAACAAACATTTTGTAAATAGAATCTATGCTACAGTAAAATAATTAA
CACAATTATTTACATGCAATACTGACAAATTTGGCACTTTTTGAAAAGAAATGTACAAAACACTTGCTTTAAAAGAAATTTAAAATTATA
AAAACTCCGAGCATTACTATCATGCACTTTGCAAATACCTCACAAGCACTTATGGCACAGCTATCAGAGAGCATCAGGCTCTCTGGTAAT

>54992_54992_1_MRPL30-EIF5B_MRPL30_chr2_99804720_ENST00000338148_EIF5B_chr2_99980734_ENST00000289371_length(amino acids)=885AA_BP=0
MAGILRLVVQWPPGRLQTVTKGVESLICTDWIRHKFTRSRIPEKERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKL
LQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEET
EKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERA
YDKAKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTGKTKILDKLRHTHVQDGEAGGITQQIGATNVPLEAINEQTKMIKNFDRENVRI
PGMLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINLLKSKKCPFIVALNKIDRLYDWKKSPDSDVAATLKKQKKNTKD
EFEERAKAIIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVELTQTMLSKRLAHCEELRAQVMEVKALPGMGTTIDV
ILINGRLKEGDTIIVPGVEGPIVTQIRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVAYKEDEIPVLKDELIH
ELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKTSEVPYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVR
IFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIAVFPCKIKILPQYIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEINH

--------------------------------------------------------------
>54992_54992_2_MRPL30-EIF5B_MRPL30_chr2_99804720_ENST00000409145_EIF5B_chr2_99980734_ENST00000289371_length(transcript)=4661nt_BP=223nt
AGTTCTTCCTCTGCTCTGCTTCCCTTCGGAGGAAAATTTCAGGCTGAAGGTTTAGCGGGTGCCGCCTCTAAAGAGAGCAATCACTACACT
TATGGCTGGGATTTTGCGCTTAGTAGTTCAATGGCCCCCAGGCAGACTACAGACTGTGACAAAAGGTGTGGAGTCTCTTATTTGTACAGA
TTGGATTCGTCACAAATTCACCAGATCAAGAATTCCAGAAAAAGAACGATTGGAACAAGAAAAAAGAGAAAGGAAAAAGCAAAAAGAAAA
AGAAAGAAAAGAACGCTTGAAAAAAGAAGGGAAACTTTTAACTAAATCCCAGAGAGAAGCCAGAGCCAGAGCCGAAGCTACTCTTAAACT
GCTACAAGCTCAGGGTGTTGAAGTGCCATCAAAAGACTCTTTGCCAAAGAAGAGGCCAATTTATGAAGATAAAAAGAGGAAAAAAATACC
ACAGCAGCTAGAAAGTAAAGAAGTGTCTGAATCAATGGAATTATGTGCTGCTGTAGAAGTTATGGAACAAGGAGTACCAGAAAAGGAAGA
GACACCACCTCCTGTTGAACCAGAAGAAGAAGAAGATACTGAGGATGCTGGATTGGATGATTGGGAAGCTATGGCCAGTGATGAGGAGAC
AGAAAAAGTAGAAGGAAACAAAGTTCATATAGAAGTAAAAGAAAACCCTGAAGAGGAGGAGGAGGAGGAAGAAGAGGAAGAAGAAGATGA
AGAAAGTGAAGAAGAGGAGGAAGAGGAGGGAGAAAGTGAAGGCAGTGAAGGTGATGAGGAAGATGAAAAGGTGTCAGATGAGAAGGATTC
AGGGAAGACATTAGATAAAAAGCCAAGTAAAGAAATGAGCTCAGATTCTGAATATGACTCTGATGATGATCGGACTAAAGAAGAAAGGGC
TTATGACAAAGCAAAACGGAGGATTGAGAAACGGCGACTTGAACATAGTAAAAATGTAAACACCGAAAAGCTAAGAGCCCCTATTATCTG
CGTACTTGGGCATGTGGACACAGGGAAGACAAAAATTCTAGATAAGCTCCGTCACACACATGTACAAGATGGTGAAGCAGGTGGTATCAC
ACAACAAATTGGGGCCACCAATGTTCCTCTTGAAGCTATTAATGAACAGACTAAGATGATTAAAAATTTTGATAGAGAGAATGTACGGAT
TCCAGGAATGCTAATTATTGATACTCCTGGGCATGAATCTTTCAGTAATCTGAGAAATAGAGGAAGCTCTCTTTGTGACATTGCCATTTT
AGTTGTTGATATTATGCATGGTTTGGAGCCCCAGACAATTGAGTCTATCAACCTTCTCAAATCTAAAAAATGTCCCTTCATTGTTGCACT
CAATAAGATTGATAGGTTATATGATTGGAAAAAGAGTCCTGACTCTGATGTGGCTGCTACTTTAAAGAAGCAGAAAAAGAATACAAAAGA
TGAATTTGAGGAGCGAGCAAAGGCTATTATTGTAGAATTTGCACAGCAGGGTTTGAATGCTGCTTTGTTTTATGAGAATAAAGATCCCCG
CACTTTTGTGTCTTTGGTACCTACCTCTGCACATACTGGTGATGGCATGGGAAGTCTGATCTACCTTCTTGTAGAGTTAACTCAGACCAT
GTTGAGCAAGAGACTTGCACACTGTGAAGAGCTGAGAGCACAGGTGATGGAGGTTAAAGCTCTCCCGGGGATGGGCACCACTATAGATGT
CATCTTGATCAATGGGCGTTTGAAGGAAGGAGATACAATCATTGTTCCTGGAGTAGAAGGGCCCATTGTAACTCAGATTCGAGGCCTCCT
GTTACCTCCTCCTATGAAGGAATTACGAGTGAAGAACCAGTATGAAAAGCATAAAGAAGTAGAAGCAGCTCAGGGGGTAAAGATTCTTGG
AAAAGACCTGGAGAAAACATTGGCTGGTTTACCCCTCCTTGTGGCTTATAAAGAAGATGAAATCCCTGTTCTTAAAGATGAATTGATCCA
TGAGTTAAAGCAGACACTAAATGCTATCAAATTAGAAGAAAAAGGAGTCTATGTCCAGGCATCTACACTGGGTTCTTTGGAAGCTCTACT
GGAATTTCTGAAAACATCAGAAGTGCCCTATGCAGGAATTAACATTGGCCCAGTGCATAAAAAAGATGTTATGAAGGCTTCAGTGATGTT
GGAACATGACCCTCAGTATGCAGTAATTTTGGCCTTCGATGTGAGAATTGAACGAGATGCACAAGAAATGGCTGATAGTTTAGGAGTTAG
AATTTTTAGTGCAGAAATTATTTATCATTTATTTGATGCCTTTACAAAATATAGACAAGACTACAAGAAACAGAAACAAGAAGAATTTAA
GCACATAGCAGTATTTCCCTGCAAGATAAAAATCCTCCCTCAGTACATTTTTAATTCTCGAGATCCGATAGTGATGGGGGTGACGGTGGA
AGCAGGTCAGGTGAAACAGGGGACACCCATGTGTGTCCCAAGCAAAAATTTTGTTGACATCGGAATAGTAACAAGTATTGAAATAAACCA
TAAACAAGTGGATGTTGCAAAAAAAGGACAAGAAGTTTGTGTAAAAATAGAACCTATCCCTGGTGAGTCACCCAAAATGTTTGGAAGACA
TTTTGAAGCTACAGATATTCTTGTTAGTAAGATCAGCCGGCAGTCCATTGATGCACTCAAAGACTGGTTCAGAGATGAAATGCAGAAGAG
TGACTGGCAGCTTATTGTGGAGCTGAAGAAAGTATTTGAAATCATCTAATTTTTTCACATGGAGCAGGAACTGGAGTAAATGCAATACTG
TGTTGTAATATCCCAACAAAAATCAGACAAAAAATGGAACAGACGTATTTGGACACTGATGGACTTAAGTATGGAAGGAAGAAAAATAGG
TGTATAAAATGTTTTCCATGAGAAACCAAGAAACTTACACTGGTTTGACAGTGGTCAGTTACATGTCCCCACAGTTCCAATGTGCCTGTT
CACTCACCTCTCCCTTCCCCAACCCTTCTCTACTTGGCTGCTGTTTTAAAGTTTGCCCTTCCCCAAATTTGGATTTTTATTACAGATCTA
AAGCTCTTTCGATTTTATACTGATTAAATCAGTACTGCAGTATTTGATTAACCAAGCTTCTGCAGATTTTGTGATTCTTGGGACTTTTTT
GACGTAAGAAATACTTCTTTATTTATGCATATTCTTCCCACAGTGATTTTTCCAGCATTCTTCTGCCATATGCCTTTAGGGCTTTTATAA
AATAGAAAATTAGGCATTCTGATATTTCTTTAGCTGCTTTGTGTGAAACCATGGTGTAAAAGCACAGCTGGCTGCTTTTTACTGCTTGTG
TAGTCACGAGTCCATTGTAATCATCACAATTCTAAACCAAACTACCAATAAAGAAAACAGACATCCACCAGTAAGCAAGCTCTGTTAGGC
TTCCATGTTAGTGTAGCTTCTCTCCCACAAGTTGTCCTCCTAGGACAAGAATTATCTTACAAACTAAACTATCATCACACTACCTTGTAT
GCCAGCACCTGGTAACAGTAGAGATTTTTATACATTAATCTTGATCTGTTTTAATCTTGATCTGTTTTAGTAGAGATTTTTATACATTAA
TCTTGATCTGTTTTAATCTTGATCTGTTTTGTCCTAGAAAATTCCATCATACACACATTTCCTGATATTTGGGCTTAGTGCTTCTAAATT
GTTGCAGACACAAAACTTAATGATTCATTCGTAGTAGTAATCTGTAGCTAGTTTTAGGGTTTTGCTGAAGTCAGTGTGGGGTGTTTGTTT
GAGGAAAAAGTTCCAAATATCCACTAGCATAGAATTTTAAACTATTTTTATTTTAAAGTTATGGCATAACATATAACATAAAAATATTTT
ATATACGTTTGAAAAATCTATACCGTTCTTTTTTATCATCAAAGTTTCTCAATGGCCAGTAGAAGCAAAAAGACAACACCACCTCTGATC
TACGGGACATAATGTTCCCAGGAAAAAAATCTTCAAGTGGGTGTGAGGGTGTTTCTAATTCAAAATATGTAGATTTCTCCGCATGGAAGA
AGTAGTAAAGATTTTCTTAACATGCTCCTGTGTTCATGCTTGGAGACAAGAATAAGATGGTTTAGAAGCTTTACCCTTTCTTGGAACAAG
TAGAATCCCGGTCTGAGACCTCTCAGGAATTTCAGAGCTTAGCAGTCTGGCCTGGAGGTTTTTCAGCCTTTTAGTATAATAAACAGTAGT
TGCTTCCTAGAGTTGAGTTTTTAAGGATTCACAAAAAGGAGCCTGTACAAAATATACATACAGTTCTTTATTAAACAACTGTAAACACTT
CACTGTAAAAATCCATAAAACTTTATAAACAAACATTTTGTAAATAGAATCTATGCTACAGTAAAATAATTAACACAATTATTTACATGC
AATACTGACAAATTTGGCACTTTTTGAAAAGAAATGTACAAAACACTTGCTTTAAAAGAAATTTAAAATTATAAAAACTCCGAGCATTAC
TATCATGCACTTTGCAAATACCTCACAAGCACTTATGGCACAGCTATCAGAGAGCATCAGGCTCTCTGGTAATATTTATGTAACTTTTAA

>54992_54992_2_MRPL30-EIF5B_MRPL30_chr2_99804720_ENST00000409145_EIF5B_chr2_99980734_ENST00000289371_length(amino acids)=885AA_BP=0
MAGILRLVVQWPPGRLQTVTKGVESLICTDWIRHKFTRSRIPEKERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKL
LQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEET
EKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERA
YDKAKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTGKTKILDKLRHTHVQDGEAGGITQQIGATNVPLEAINEQTKMIKNFDRENVRI
PGMLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINLLKSKKCPFIVALNKIDRLYDWKKSPDSDVAATLKKQKKNTKD
EFEERAKAIIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVELTQTMLSKRLAHCEELRAQVMEVKALPGMGTTIDV
ILINGRLKEGDTIIVPGVEGPIVTQIRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVAYKEDEIPVLKDELIH
ELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKTSEVPYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVR
IFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIAVFPCKIKILPQYIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEINH

--------------------------------------------------------------
>54992_54992_3_MRPL30-EIF5B_MRPL30_chr2_99804720_ENST00000410042_EIF5B_chr2_99980734_ENST00000289371_length(transcript)=4777nt_BP=339nt
GCACTTTTCCAGCTCGAGCCCTCACGAGGCCGTGGGTACGACCGGAAGCCGCAGACTGAATCTCGCTCTGTTGCCCAGCCCATCTCGGCC
CACTGAAACCTCCACCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGAGATTACAGGCGCCTGCCACCACGCCCAG
CCTCTAAAGAGAGCAATCACTACACTTATGGCTGGGATTTTGCGCTTAGTAGTTCAATGGCCCCCAGGCAGACTACAGACTGTGACAAAA
GGTGTGGAGTCTCTTATTTGTACAGATTGGATTCGTCACAAATTCACCAGATCAAGAATTCCAGAAAAAGAACGATTGGAACAAGAAAAA
AGAGAAAGGAAAAAGCAAAAAGAAAAAGAAAGAAAAGAACGCTTGAAAAAAGAAGGGAAACTTTTAACTAAATCCCAGAGAGAAGCCAGA
GCCAGAGCCGAAGCTACTCTTAAACTGCTACAAGCTCAGGGTGTTGAAGTGCCATCAAAAGACTCTTTGCCAAAGAAGAGGCCAATTTAT
GAAGATAAAAAGAGGAAAAAAATACCACAGCAGCTAGAAAGTAAAGAAGTGTCTGAATCAATGGAATTATGTGCTGCTGTAGAAGTTATG
GAACAAGGAGTACCAGAAAAGGAAGAGACACCACCTCCTGTTGAACCAGAAGAAGAAGAAGATACTGAGGATGCTGGATTGGATGATTGG
GAAGCTATGGCCAGTGATGAGGAGACAGAAAAAGTAGAAGGAAACAAAGTTCATATAGAAGTAAAAGAAAACCCTGAAGAGGAGGAGGAG
GAGGAAGAAGAGGAAGAAGAAGATGAAGAAAGTGAAGAAGAGGAGGAAGAGGAGGGAGAAAGTGAAGGCAGTGAAGGTGATGAGGAAGAT
GAAAAGGTGTCAGATGAGAAGGATTCAGGGAAGACATTAGATAAAAAGCCAAGTAAAGAAATGAGCTCAGATTCTGAATATGACTCTGAT
GATGATCGGACTAAAGAAGAAAGGGCTTATGACAAAGCAAAACGGAGGATTGAGAAACGGCGACTTGAACATAGTAAAAATGTAAACACC
GAAAAGCTAAGAGCCCCTATTATCTGCGTACTTGGGCATGTGGACACAGGGAAGACAAAAATTCTAGATAAGCTCCGTCACACACATGTA
CAAGATGGTGAAGCAGGTGGTATCACACAACAAATTGGGGCCACCAATGTTCCTCTTGAAGCTATTAATGAACAGACTAAGATGATTAAA
AATTTTGATAGAGAGAATGTACGGATTCCAGGAATGCTAATTATTGATACTCCTGGGCATGAATCTTTCAGTAATCTGAGAAATAGAGGA
AGCTCTCTTTGTGACATTGCCATTTTAGTTGTTGATATTATGCATGGTTTGGAGCCCCAGACAATTGAGTCTATCAACCTTCTCAAATCT
AAAAAATGTCCCTTCATTGTTGCACTCAATAAGATTGATAGGTTATATGATTGGAAAAAGAGTCCTGACTCTGATGTGGCTGCTACTTTA
AAGAAGCAGAAAAAGAATACAAAAGATGAATTTGAGGAGCGAGCAAAGGCTATTATTGTAGAATTTGCACAGCAGGGTTTGAATGCTGCT
TTGTTTTATGAGAATAAAGATCCCCGCACTTTTGTGTCTTTGGTACCTACCTCTGCACATACTGGTGATGGCATGGGAAGTCTGATCTAC
CTTCTTGTAGAGTTAACTCAGACCATGTTGAGCAAGAGACTTGCACACTGTGAAGAGCTGAGAGCACAGGTGATGGAGGTTAAAGCTCTC
CCGGGGATGGGCACCACTATAGATGTCATCTTGATCAATGGGCGTTTGAAGGAAGGAGATACAATCATTGTTCCTGGAGTAGAAGGGCCC
ATTGTAACTCAGATTCGAGGCCTCCTGTTACCTCCTCCTATGAAGGAATTACGAGTGAAGAACCAGTATGAAAAGCATAAAGAAGTAGAA
GCAGCTCAGGGGGTAAAGATTCTTGGAAAAGACCTGGAGAAAACATTGGCTGGTTTACCCCTCCTTGTGGCTTATAAAGAAGATGAAATC
CCTGTTCTTAAAGATGAATTGATCCATGAGTTAAAGCAGACACTAAATGCTATCAAATTAGAAGAAAAAGGAGTCTATGTCCAGGCATCT
ACACTGGGTTCTTTGGAAGCTCTACTGGAATTTCTGAAAACATCAGAAGTGCCCTATGCAGGAATTAACATTGGCCCAGTGCATAAAAAA
GATGTTATGAAGGCTTCAGTGATGTTGGAACATGACCCTCAGTATGCAGTAATTTTGGCCTTCGATGTGAGAATTGAACGAGATGCACAA
GAAATGGCTGATAGTTTAGGAGTTAGAATTTTTAGTGCAGAAATTATTTATCATTTATTTGATGCCTTTACAAAATATAGACAAGACTAC
AAGAAACAGAAACAAGAAGAATTTAAGCACATAGCAGTATTTCCCTGCAAGATAAAAATCCTCCCTCAGTACATTTTTAATTCTCGAGAT
CCGATAGTGATGGGGGTGACGGTGGAAGCAGGTCAGGTGAAACAGGGGACACCCATGTGTGTCCCAAGCAAAAATTTTGTTGACATCGGA
ATAGTAACAAGTATTGAAATAAACCATAAACAAGTGGATGTTGCAAAAAAAGGACAAGAAGTTTGTGTAAAAATAGAACCTATCCCTGGT
GAGTCACCCAAAATGTTTGGAAGACATTTTGAAGCTACAGATATTCTTGTTAGTAAGATCAGCCGGCAGTCCATTGATGCACTCAAAGAC
TGGTTCAGAGATGAAATGCAGAAGAGTGACTGGCAGCTTATTGTGGAGCTGAAGAAAGTATTTGAAATCATCTAATTTTTTCACATGGAG
CAGGAACTGGAGTAAATGCAATACTGTGTTGTAATATCCCAACAAAAATCAGACAAAAAATGGAACAGACGTATTTGGACACTGATGGAC
TTAAGTATGGAAGGAAGAAAAATAGGTGTATAAAATGTTTTCCATGAGAAACCAAGAAACTTACACTGGTTTGACAGTGGTCAGTTACAT
GTCCCCACAGTTCCAATGTGCCTGTTCACTCACCTCTCCCTTCCCCAACCCTTCTCTACTTGGCTGCTGTTTTAAAGTTTGCCCTTCCCC
AAATTTGGATTTTTATTACAGATCTAAAGCTCTTTCGATTTTATACTGATTAAATCAGTACTGCAGTATTTGATTAACCAAGCTTCTGCA
GATTTTGTGATTCTTGGGACTTTTTTGACGTAAGAAATACTTCTTTATTTATGCATATTCTTCCCACAGTGATTTTTCCAGCATTCTTCT
GCCATATGCCTTTAGGGCTTTTATAAAATAGAAAATTAGGCATTCTGATATTTCTTTAGCTGCTTTGTGTGAAACCATGGTGTAAAAGCA
CAGCTGGCTGCTTTTTACTGCTTGTGTAGTCACGAGTCCATTGTAATCATCACAATTCTAAACCAAACTACCAATAAAGAAAACAGACAT
CCACCAGTAAGCAAGCTCTGTTAGGCTTCCATGTTAGTGTAGCTTCTCTCCCACAAGTTGTCCTCCTAGGACAAGAATTATCTTACAAAC
TAAACTATCATCACACTACCTTGTATGCCAGCACCTGGTAACAGTAGAGATTTTTATACATTAATCTTGATCTGTTTTAATCTTGATCTG
TTTTAGTAGAGATTTTTATACATTAATCTTGATCTGTTTTAATCTTGATCTGTTTTGTCCTAGAAAATTCCATCATACACACATTTCCTG
ATATTTGGGCTTAGTGCTTCTAAATTGTTGCAGACACAAAACTTAATGATTCATTCGTAGTAGTAATCTGTAGCTAGTTTTAGGGTTTTG
CTGAAGTCAGTGTGGGGTGTTTGTTTGAGGAAAAAGTTCCAAATATCCACTAGCATAGAATTTTAAACTATTTTTATTTTAAAGTTATGG
CATAACATATAACATAAAAATATTTTATATACGTTTGAAAAATCTATACCGTTCTTTTTTATCATCAAAGTTTCTCAATGGCCAGTAGAA
GCAAAAAGACAACACCACCTCTGATCTACGGGACATAATGTTCCCAGGAAAAAAATCTTCAAGTGGGTGTGAGGGTGTTTCTAATTCAAA
ATATGTAGATTTCTCCGCATGGAAGAAGTAGTAAAGATTTTCTTAACATGCTCCTGTGTTCATGCTTGGAGACAAGAATAAGATGGTTTA
GAAGCTTTACCCTTTCTTGGAACAAGTAGAATCCCGGTCTGAGACCTCTCAGGAATTTCAGAGCTTAGCAGTCTGGCCTGGAGGTTTTTC
AGCCTTTTAGTATAATAAACAGTAGTTGCTTCCTAGAGTTGAGTTTTTAAGGATTCACAAAAAGGAGCCTGTACAAAATATACATACAGT
TCTTTATTAAACAACTGTAAACACTTCACTGTAAAAATCCATAAAACTTTATAAACAAACATTTTGTAAATAGAATCTATGCTACAGTAA
AATAATTAACACAATTATTTACATGCAATACTGACAAATTTGGCACTTTTTGAAAAGAAATGTACAAAACACTTGCTTTAAAAGAAATTT
AAAATTATAAAAACTCCGAGCATTACTATCATGCACTTTGCAAATACCTCACAAGCACTTATGGCACAGCTATCAGAGAGCATCAGGCTC
TCTGGTAATATTTATGTAACTTTTAATGTGCTTCCATAAGTTTGTTGTAAAACCACCTGGACATTGTCAAGAATAAAGTCAAATGCCATA

>54992_54992_3_MRPL30-EIF5B_MRPL30_chr2_99804720_ENST00000410042_EIF5B_chr2_99980734_ENST00000289371_length(amino acids)=885AA_BP=0
MAGILRLVVQWPPGRLQTVTKGVESLICTDWIRHKFTRSRIPEKERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKL
LQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEET
EKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERA
YDKAKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTGKTKILDKLRHTHVQDGEAGGITQQIGATNVPLEAINEQTKMIKNFDRENVRI
PGMLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINLLKSKKCPFIVALNKIDRLYDWKKSPDSDVAATLKKQKKNTKD
EFEERAKAIIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVELTQTMLSKRLAHCEELRAQVMEVKALPGMGTTIDV
ILINGRLKEGDTIIVPGVEGPIVTQIRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVAYKEDEIPVLKDELIH
ELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKTSEVPYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVR
IFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIAVFPCKIKILPQYIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEINH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MRPL30-EIF5B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MRPL30-EIF5B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MRPL30-EIF5B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource