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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MRPL33-GPN1 (FusionGDB2 ID:55006)

Fusion Gene Summary for MRPL33-GPN1

Fusion gene summary

Fusion gene information	Fusion gene name: MRPL33-GPN1
	Fusion gene ID: 55006
		Hgene	Tgene
	Gene symbol	MRPL33	GPN1
	Gene ID	9553	11321
	Gene name	mitochondrial ribosomal protein L33	GPN-loop GTPase 1
	Synonyms	C2orf1\|L33mt\|MRP-L33\|RPL33L	ATPBD1A\|MBDIN\|NTPBP\|RPAP4\|XAB1
	Cytomap	2p23.2	2p23.3
	Type of gene	protein-coding	protein-coding
	Description	39S ribosomal protein L33, mitochondrialmitochondrial large ribosomal subunit protein bL33m	GPN-loop GTPase 1ATP(GTP)-binding proteinMBD2-interacting proteinRNA polymerase II associated protein 4RNAPII-associated protein 4XPA binding protein 1, GTPase
	Modification date	20200313	20200328
	UniProtAcc	O75394	Q9HCN4
	Ensembl transtripts involved in fusion gene	ENST00000483992, ENST00000296102, ENST00000379666,	ENST00000461249, ENST00000264718, ENST00000407583, ENST00000424214, ENST00000458167, ENST00000610189, ENST00000503738, ENST00000515877,
Fusion gene scores	* DoF score	10 X 8 X 9=720	7 X 8 X 7=392
	# samples	15	11
	** MAII score	log2(15/720*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/392*10)=-1.83335013059055 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MRPL33 [Title/Abstract] AND GPN1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MRPL33(27995559)-GPN1(27852726), # samples:1 MRPL33(28152775)-GPN1(27852726), # samples:1 MRPL33(27997397)-GPN1(27870703), # samples:1 MRPL33(28152775)-GPN1(27872982), # samples:1 MRPL33(28117551)-GPN1(27870703), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MRPL33 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GPN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ACC	TCGA-OR-A5LO-01A	MRPL33	chr2	27995559	+	GPN1	chr2	27852726	+
ChimerDB4	STAD	TCGA-BR-8077-01A	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+
ChimerDB4	STAD	TCGA-VQ-A91K-01A	MRPL33	chr2	28152775	+	GPN1	chr2	27852726	+
ChimerDB4	UCEC	TCGA-B5-A0JN-01A	MRPL33	chr2	28152775	+	GPN1	chr2	27872982	+
ChimerDB4	UCS	TCGA-N9-A4Q1	MRPL33	chr2	28117551	+	GPN1	chr2	27870703	+

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Fusion Gene ORF analysis for MRPL33-GPN1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3UTR	ENST00000483992	ENST00000461249	MRPL33	chr2	27995559	+	GPN1	chr2	27852726	+
3UTR-5UTR	ENST00000483992	ENST00000264718	MRPL33	chr2	27995559	+	GPN1	chr2	27852726	+
3UTR-5UTR	ENST00000483992	ENST00000407583	MRPL33	chr2	27995559	+	GPN1	chr2	27852726	+
3UTR-5UTR	ENST00000483992	ENST00000424214	MRPL33	chr2	27995559	+	GPN1	chr2	27852726	+
3UTR-5UTR	ENST00000483992	ENST00000458167	MRPL33	chr2	27995559	+	GPN1	chr2	27852726	+
3UTR-5UTR	ENST00000483992	ENST00000610189	MRPL33	chr2	27995559	+	GPN1	chr2	27852726	+
3UTR-intron	ENST00000483992	ENST00000503738	MRPL33	chr2	27995559	+	GPN1	chr2	27852726	+
3UTR-intron	ENST00000483992	ENST00000515877	MRPL33	chr2	27995559	+	GPN1	chr2	27852726	+
5CDS-3UTR	ENST00000296102	ENST00000461249	MRPL33	chr2	27995559	+	GPN1	chr2	27852726	+
5CDS-3UTR	ENST00000296102	ENST00000461249	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+
5CDS-3UTR	ENST00000379666	ENST00000461249	MRPL33	chr2	27995559	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000296102	ENST00000264718	MRPL33	chr2	27995559	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000296102	ENST00000407583	MRPL33	chr2	27995559	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000296102	ENST00000424214	MRPL33	chr2	27995559	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000296102	ENST00000458167	MRPL33	chr2	27995559	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000296102	ENST00000610189	MRPL33	chr2	27995559	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000379666	ENST00000264718	MRPL33	chr2	27995559	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000379666	ENST00000407583	MRPL33	chr2	27995559	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000379666	ENST00000424214	MRPL33	chr2	27995559	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000379666	ENST00000458167	MRPL33	chr2	27995559	+	GPN1	chr2	27852726	+
5CDS-5UTR	ENST00000379666	ENST00000610189	MRPL33	chr2	27995559	+	GPN1	chr2	27852726	+
5CDS-intron	ENST00000296102	ENST00000503738	MRPL33	chr2	27995559	+	GPN1	chr2	27852726	+
5CDS-intron	ENST00000296102	ENST00000515877	MRPL33	chr2	27995559	+	GPN1	chr2	27852726	+
5CDS-intron	ENST00000379666	ENST00000503738	MRPL33	chr2	27995559	+	GPN1	chr2	27852726	+
5CDS-intron	ENST00000379666	ENST00000515877	MRPL33	chr2	27995559	+	GPN1	chr2	27852726	+
In-frame	ENST00000296102	ENST00000264718	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+
In-frame	ENST00000296102	ENST00000407583	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+
In-frame	ENST00000296102	ENST00000424214	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+
In-frame	ENST00000296102	ENST00000458167	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+
In-frame	ENST00000296102	ENST00000503738	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+
In-frame	ENST00000296102	ENST00000515877	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+
In-frame	ENST00000296102	ENST00000610189	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000296102	ENST00000264718	MRPL33	chr2	28152775	+	GPN1	chr2	27872982	+
intron-3CDS	ENST00000296102	ENST00000264718	MRPL33	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000296102	ENST00000407583	MRPL33	chr2	28152775	+	GPN1	chr2	27872982	+
intron-3CDS	ENST00000296102	ENST00000407583	MRPL33	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000296102	ENST00000424214	MRPL33	chr2	28152775	+	GPN1	chr2	27872982	+
intron-3CDS	ENST00000296102	ENST00000424214	MRPL33	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000296102	ENST00000458167	MRPL33	chr2	28152775	+	GPN1	chr2	27872982	+
intron-3CDS	ENST00000296102	ENST00000458167	MRPL33	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000296102	ENST00000503738	MRPL33	chr2	28152775	+	GPN1	chr2	27872982	+
intron-3CDS	ENST00000296102	ENST00000503738	MRPL33	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000296102	ENST00000515877	MRPL33	chr2	28152775	+	GPN1	chr2	27872982	+
intron-3CDS	ENST00000296102	ENST00000515877	MRPL33	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000296102	ENST00000610189	MRPL33	chr2	28152775	+	GPN1	chr2	27872982	+
intron-3CDS	ENST00000296102	ENST00000610189	MRPL33	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000379666	ENST00000264718	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000379666	ENST00000264718	MRPL33	chr2	28152775	+	GPN1	chr2	27872982	+
intron-3CDS	ENST00000379666	ENST00000264718	MRPL33	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000379666	ENST00000407583	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000379666	ENST00000407583	MRPL33	chr2	28152775	+	GPN1	chr2	27872982	+
intron-3CDS	ENST00000379666	ENST00000407583	MRPL33	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000379666	ENST00000424214	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000379666	ENST00000424214	MRPL33	chr2	28152775	+	GPN1	chr2	27872982	+
intron-3CDS	ENST00000379666	ENST00000424214	MRPL33	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000379666	ENST00000458167	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000379666	ENST00000458167	MRPL33	chr2	28152775	+	GPN1	chr2	27872982	+
intron-3CDS	ENST00000379666	ENST00000458167	MRPL33	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000379666	ENST00000503738	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000379666	ENST00000503738	MRPL33	chr2	28152775	+	GPN1	chr2	27872982	+
intron-3CDS	ENST00000379666	ENST00000503738	MRPL33	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000379666	ENST00000515877	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000379666	ENST00000515877	MRPL33	chr2	28152775	+	GPN1	chr2	27872982	+
intron-3CDS	ENST00000379666	ENST00000515877	MRPL33	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000379666	ENST00000610189	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000379666	ENST00000610189	MRPL33	chr2	28152775	+	GPN1	chr2	27872982	+
intron-3CDS	ENST00000379666	ENST00000610189	MRPL33	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000483992	ENST00000264718	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000483992	ENST00000264718	MRPL33	chr2	28152775	+	GPN1	chr2	27872982	+
intron-3CDS	ENST00000483992	ENST00000264718	MRPL33	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000483992	ENST00000407583	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000483992	ENST00000407583	MRPL33	chr2	28152775	+	GPN1	chr2	27872982	+
intron-3CDS	ENST00000483992	ENST00000407583	MRPL33	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000483992	ENST00000424214	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000483992	ENST00000424214	MRPL33	chr2	28152775	+	GPN1	chr2	27872982	+
intron-3CDS	ENST00000483992	ENST00000424214	MRPL33	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000483992	ENST00000458167	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000483992	ENST00000458167	MRPL33	chr2	28152775	+	GPN1	chr2	27872982	+
intron-3CDS	ENST00000483992	ENST00000458167	MRPL33	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000483992	ENST00000503738	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000483992	ENST00000503738	MRPL33	chr2	28152775	+	GPN1	chr2	27872982	+
intron-3CDS	ENST00000483992	ENST00000503738	MRPL33	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000483992	ENST00000515877	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000483992	ENST00000515877	MRPL33	chr2	28152775	+	GPN1	chr2	27872982	+
intron-3CDS	ENST00000483992	ENST00000515877	MRPL33	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000483992	ENST00000610189	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+
intron-3CDS	ENST00000483992	ENST00000610189	MRPL33	chr2	28152775	+	GPN1	chr2	27872982	+
intron-3CDS	ENST00000483992	ENST00000610189	MRPL33	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3UTR	ENST00000296102	ENST00000461249	MRPL33	chr2	28152775	+	GPN1	chr2	27852726	+
intron-3UTR	ENST00000296102	ENST00000461249	MRPL33	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3UTR	ENST00000379666	ENST00000461249	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+
intron-3UTR	ENST00000379666	ENST00000461249	MRPL33	chr2	28152775	+	GPN1	chr2	27852726	+
intron-3UTR	ENST00000379666	ENST00000461249	MRPL33	chr2	28117551	+	GPN1	chr2	27870703	+
intron-3UTR	ENST00000483992	ENST00000461249	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+
intron-3UTR	ENST00000483992	ENST00000461249	MRPL33	chr2	28152775	+	GPN1	chr2	27852726	+
intron-3UTR	ENST00000483992	ENST00000461249	MRPL33	chr2	28117551	+	GPN1	chr2	27870703	+
intron-5UTR	ENST00000296102	ENST00000264718	MRPL33	chr2	28152775	+	GPN1	chr2	27852726	+
intron-5UTR	ENST00000296102	ENST00000407583	MRPL33	chr2	28152775	+	GPN1	chr2	27852726	+
intron-5UTR	ENST00000296102	ENST00000424214	MRPL33	chr2	28152775	+	GPN1	chr2	27852726	+
intron-5UTR	ENST00000296102	ENST00000458167	MRPL33	chr2	28152775	+	GPN1	chr2	27852726	+
intron-5UTR	ENST00000296102	ENST00000610189	MRPL33	chr2	28152775	+	GPN1	chr2	27852726	+
intron-5UTR	ENST00000379666	ENST00000264718	MRPL33	chr2	28152775	+	GPN1	chr2	27852726	+
intron-5UTR	ENST00000379666	ENST00000407583	MRPL33	chr2	28152775	+	GPN1	chr2	27852726	+
intron-5UTR	ENST00000379666	ENST00000424214	MRPL33	chr2	28152775	+	GPN1	chr2	27852726	+
intron-5UTR	ENST00000379666	ENST00000458167	MRPL33	chr2	28152775	+	GPN1	chr2	27852726	+
intron-5UTR	ENST00000379666	ENST00000610189	MRPL33	chr2	28152775	+	GPN1	chr2	27852726	+
intron-5UTR	ENST00000483992	ENST00000264718	MRPL33	chr2	28152775	+	GPN1	chr2	27852726	+
intron-5UTR	ENST00000483992	ENST00000407583	MRPL33	chr2	28152775	+	GPN1	chr2	27852726	+
intron-5UTR	ENST00000483992	ENST00000424214	MRPL33	chr2	28152775	+	GPN1	chr2	27852726	+
intron-5UTR	ENST00000483992	ENST00000458167	MRPL33	chr2	28152775	+	GPN1	chr2	27852726	+
intron-5UTR	ENST00000483992	ENST00000610189	MRPL33	chr2	28152775	+	GPN1	chr2	27852726	+
intron-intron	ENST00000296102	ENST00000461249	MRPL33	chr2	28152775	+	GPN1	chr2	27872982	+
intron-intron	ENST00000296102	ENST00000503738	MRPL33	chr2	28152775	+	GPN1	chr2	27852726	+
intron-intron	ENST00000296102	ENST00000515877	MRPL33	chr2	28152775	+	GPN1	chr2	27852726	+
intron-intron	ENST00000379666	ENST00000461249	MRPL33	chr2	28152775	+	GPN1	chr2	27872982	+
intron-intron	ENST00000379666	ENST00000503738	MRPL33	chr2	28152775	+	GPN1	chr2	27852726	+
intron-intron	ENST00000379666	ENST00000515877	MRPL33	chr2	28152775	+	GPN1	chr2	27852726	+
intron-intron	ENST00000483992	ENST00000461249	MRPL33	chr2	28152775	+	GPN1	chr2	27872982	+
intron-intron	ENST00000483992	ENST00000503738	MRPL33	chr2	28152775	+	GPN1	chr2	27852726	+
intron-intron	ENST00000483992	ENST00000515877	MRPL33	chr2	28152775	+	GPN1	chr2	27852726	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000296102	MRPL33	chr2	27997397	+	ENST00000515877	GPN1	chr2	27870703	+	566	209	4	402	132
ENST00000296102	MRPL33	chr2	27997397	+	ENST00000503738	GPN1	chr2	27870703	+	412	209	4	402	132
ENST00000296102	MRPL33	chr2	27997397	+	ENST00000458167	GPN1	chr2	27870703	+	1047	209	4	402	132
ENST00000296102	MRPL33	chr2	27997397	+	ENST00000424214	GPN1	chr2	27870703	+	1047	209	4	402	132
ENST00000296102	MRPL33	chr2	27997397	+	ENST00000407583	GPN1	chr2	27870703	+	659	209	4	402	132
ENST00000296102	MRPL33	chr2	27997397	+	ENST00000264718	GPN1	chr2	27870703	+	1711	209	4	402	132
ENST00000296102	MRPL33	chr2	27997397	+	ENST00000610189	GPN1	chr2	27870703	+	1049	209	4	402	132

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000296102	ENST00000515877	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+	0.008137914	0.99186206
ENST00000296102	ENST00000503738	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+	0.008574724	0.9914253
ENST00000296102	ENST00000458167	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+	0.011210502	0.98878944
ENST00000296102	ENST00000424214	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+	0.011210502	0.98878944
ENST00000296102	ENST00000407583	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+	0.013373609	0.9866263
ENST00000296102	ENST00000264718	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+	0.012890339	0.98710966
ENST00000296102	ENST00000610189	MRPL33	chr2	27997397	+	GPN1	chr2	27870703	+	0.01115881	0.98884124

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Fusion Genomic Features for MRPL33-GPN1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MRPL33-GPN1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:27995559/chr2:27852726)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MRPL33 O75394	GPN1 Q9HCN4
	FUNCTION: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119). {ECO:0000269\|PubMed:17643375, ECO:0000269\|PubMed:20855544, ECO:0000269\|PubMed:21768307, ECO:0000305\|PubMed:11058119}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

GPN1

chr2:27997397

chr2:27870703

ENST00000407583

86_88

298

363.0

Motif

Gly-Pro-Asn (GPN)-loop%3B involved in dimer interface

Tgene

GPN1

chr2:27997397

chr2:27870703

ENST00000424214

86_88

231

296.0

Motif

Gly-Pro-Asn (GPN)-loop%3B involved in dimer interface

Tgene

GPN1

chr2:27997397

chr2:27870703

ENST00000458167

86_88

215

280.0

Motif

Gly-Pro-Asn (GPN)-loop%3B involved in dimer interface

Tgene

GPN1

chr2:27997397

chr2:27870703

ENST00000503738

86_88

215

280.0

Motif

Gly-Pro-Asn (GPN)-loop%3B involved in dimer interface

Tgene

GPN1

chr2:27997397

chr2:27870703

ENST00000515877

86_88

231

296.0

Motif

Gly-Pro-Asn (GPN)-loop%3B involved in dimer interface

Tgene

GPN1

chr2:27997397

chr2:27870703

ENST00000407583

189_192

298

363.0

Nucleotide binding

GTP

Tgene

GPN1

chr2:27997397

chr2:27870703

ENST00000407583

29_34

298

363.0

Nucleotide binding

GTP

Tgene

GPN1

chr2:27997397

chr2:27870703

ENST00000424214

189_192

231

296.0

Nucleotide binding

GTP

Tgene

GPN1

chr2:27997397

chr2:27870703

ENST00000424214

29_34

231

296.0

Nucleotide binding

GTP

Tgene

GPN1

chr2:27997397

chr2:27870703

ENST00000458167

189_192

215

280.0

Nucleotide binding

GTP

Tgene

GPN1

chr2:27997397

chr2:27870703

ENST00000458167

29_34

215

280.0

Nucleotide binding

GTP

Tgene

GPN1

chr2:27997397

chr2:27870703

ENST00000503738

189_192

215

280.0

Nucleotide binding

GTP

Tgene

GPN1

chr2:27997397

chr2:27870703

ENST00000503738

29_34

215

280.0

Nucleotide binding

GTP

Tgene

GPN1

chr2:27997397

chr2:27870703

ENST00000515877

189_192

231

296.0

Nucleotide binding

GTP

Tgene

GPN1

chr2:27997397

chr2:27870703

ENST00000515877

29_34

231

296.0

Nucleotide binding

GTP

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Fusion Gene Sequence for MRPL33-GPN1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>55006_55006_1_MRPL33-GPN1_MRPL33_chr2_27997397_ENST00000296102_GPN1_chr2_27870703_ENST00000264718_length(transcript)=1711nt_BP=209nt
GCAGTTGTTGTTGGTTGGGGGCCTTTTGGCCGGTGACGGAGACTGCCCAGGTGTGGTCACCATGTTCCTCTCCGCGGTCTTCTTTGCCAA
GAGCAAGTCAAAAAACATTCTGGTGAGAATGGTGAGCGAAGCTGGGACAGGTTTCTGCTTCAACACCAAGAGAAACCGACTGCGGGAAAA
ACTGACTCTTTTGCATTATGATCCAGTTGACAGCTTATCTCCTGTGCTGCACCCTTCTGATTTGATCCTGACTCGAGGAACCTTGGATGA
AGAGGATGAGGAAGCAGACAGCGATACTGATGACATTGACCACAGAGTTACAGAGGAAAGCCATGAAGAGCCAGCATTCCAGAATTTTAT
GCAAGAATCGATGGCACAATACTGGAAGAGAAACAATAAATAGGAGACTTTAGCACACTTCACTTGTTTCTAGAAGTCCAGAATTTTGGA
CCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGGGGCTCCCATAAGGGATAATTTTCCTCAGAGTAGCAAAGTTTCTCTTATTAGA
GAAATCTTGTGACTCAGATGAAGTCAGGGATAGAAGACCCTTGGACCTGGCAGGTTAATGCTGATTATTCCTTGGCCTTTCCCTTGTATT
TATGCAAGGAAGGATATACTGAGCTGATACTCTTCCAAGCCTACAACTTCAAGTTTTATCATTTGAACTCAAGTACTTTTGCTGCTGAGG
AATGGAATCAAAAGAACGTAGTCTCCTGGTGACCACCTCAGATCTCTATTATTAGGCTAGATGTATAGCCTCTACTCCCCCAGCTTCTTG
CTCTTGACCCTGCACTGTAAGTTGCCCTTCTATTAGCAGCCAAGGAAAAGGGAAACATGAGCTTATCCAGAACGGTGGCAGAGTCTCCTT
GGCAATCAACCAACGTTGCTATGAAATATGCCTCACACTGTATAGCTCATTATAGGACGTCAGGTTTGTTGAAAAAAGTGGGCAAGACAT
GATTAATGAATCAGAATCCTGTTTCATTGGTGACTTGGATAAAGACTTTTTAATTTTAACTTTGTTCTAAGACTGCTTGTCATGATTTCA
AATTAGAAAATTATATAATTGCAAACAGCTTCACTTCTCCTGTTCAACAGAGGCTTAAGGCCAGATGTCCAAACTTGTCTCAATAAGGAG
GTGATATTTTACTAAAGTTTCCCACGTGCACATACTGACTAAATACAGAGCTAGGCCCAGTTTGTATTGTACTCTGAACTTAATGCAAAG
TCTCCTTGGTGATTTTCGCAAAGTCCGTGGATTTGGGTCAGAGGCACATTTCATACATAACAGCCCTTATAAACGTTTGCCCTGCCTCCA
CATTTTACAGTATCTTAAAACAGTACATTTCTTTCAAAGAATTTTATCTCTATGAGTCAGTACTCCAACTTAGTGGTTCTCACATTGTGG
ACCAGGAGCATCAGCATCATCTGGGGAATTGTTCAACTTACCTCTTATAACCTATGAACTCAGAAACCCTGGGGGTGGGCTGAGCAGTCT
GTTTTAGAAAGCCCTCCATGTGATTCTGATGCATAGTAGCCTATGACATAATTCCAGACCAGGTGAATCTCAAGATACTAATCCTCACAT
CATTTGCCTTCTCATATTTCCCTCGTCTTGACCATCTGGTGCCTGTTATGCAGTTTAACATTCTGCAGCAATAAAAGTGTTTTATTATAA

>55006_55006_1_MRPL33-GPN1_MRPL33_chr2_27997397_ENST00000296102_GPN1_chr2_27870703_ENST00000264718_length(amino acids)=132AA_BP=67
MLLVGGLLAGDGDCPGVVTMFLSAVFFAKSKSKNILVRMVSEAGTGFCFNTKRNRLREKLTLLHYDPVDSLSPVLHPSDLILTRGTLDEE

--------------------------------------------------------------
>55006_55006_2_MRPL33-GPN1_MRPL33_chr2_27997397_ENST00000296102_GPN1_chr2_27870703_ENST00000407583_length(transcript)=659nt_BP=209nt
GCAGTTGTTGTTGGTTGGGGGCCTTTTGGCCGGTGACGGAGACTGCCCAGGTGTGGTCACCATGTTCCTCTCCGCGGTCTTCTTTGCCAA
GAGCAAGTCAAAAAACATTCTGGTGAGAATGGTGAGCGAAGCTGGGACAGGTTTCTGCTTCAACACCAAGAGAAACCGACTGCGGGAAAA
ACTGACTCTTTTGCATTATGATCCAGTTGACAGCTTATCTCCTGTGCTGCACCCTTCTGATTTGATCCTGACTCGAGGAACCTTGGATGA
AGAGGATGAGGAAGCAGACAGCGATACTGATGACATTGACCACAGAGTTACAGAGGAAAGCCATGAAGAGCCAGCATTCCAGAATTTTAT
GCAAGAATCGATGGCACAATACTGGAAGAGAAACAATAAATAGGAGACTTTAGCACACTTCACTTGTTTCTAGAAGTCCAGAATTTTGGA
CCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGGGGCTCCCATAAGGGATAATTTTCCTCAGAGTAGCAAAGTTTCTCTTATTAGA
GAAATCTTGTGACTCAGATGAAGTCAGGGATAGAAGACCCTTGGACCTGGCAGGTTAATGCTGATTATTCCTTGGCCTTTCCCTTGTATT

>55006_55006_2_MRPL33-GPN1_MRPL33_chr2_27997397_ENST00000296102_GPN1_chr2_27870703_ENST00000407583_length(amino acids)=132AA_BP=67
MLLVGGLLAGDGDCPGVVTMFLSAVFFAKSKSKNILVRMVSEAGTGFCFNTKRNRLREKLTLLHYDPVDSLSPVLHPSDLILTRGTLDEE

--------------------------------------------------------------
>55006_55006_3_MRPL33-GPN1_MRPL33_chr2_27997397_ENST00000296102_GPN1_chr2_27870703_ENST00000424214_length(transcript)=1047nt_BP=209nt
GCAGTTGTTGTTGGTTGGGGGCCTTTTGGCCGGTGACGGAGACTGCCCAGGTGTGGTCACCATGTTCCTCTCCGCGGTCTTCTTTGCCAA
GAGCAAGTCAAAAAACATTCTGGTGAGAATGGTGAGCGAAGCTGGGACAGGTTTCTGCTTCAACACCAAGAGAAACCGACTGCGGGAAAA
ACTGACTCTTTTGCATTATGATCCAGTTGACAGCTTATCTCCTGTGCTGCACCCTTCTGATTTGATCCTGACTCGAGGAACCTTGGATGA
AGAGGATGAGGAAGCAGACAGCGATACTGATGACATTGACCACAGAGTTACAGAGGAAAGCCATGAAGAGCCAGCATTCCAGAATTTTAT
GCAAGAATCGATGGCACAATACTGGAAGAGAAACAATAAATAGGAGACTTTAGCACACTTCACTTGTTTCTAGAAGTCCAGAATTTTGGA
CCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGGGGCTCCCATAAGGGATAATTTTCCTCAGAGTAGCAAAGTTTCTCTTATTAGA
GAAATCTTGTGACTCAGATGAAGTCAGGGATAGAAGACCCTTGGACCTGGCAGGTTAATGCTGATTATTCCTTGGCCTTTCCCTTGTATT
TATGCAAGGAAGGATATACTGAGCTGATACTCTTCCAAGCCTACAACTTCAAGTTTTATCATTTGAACTCAAGTACTTTTGCTGCTGAGG
AATGGAATCAAAAGAACGTAGTCTCCTGGTGACCACCTCAGATCTCTATTATTAGGCTAGATGTATAGCCTCTACTCCCCCAGCTTCTTG
CTCTTGACCCTGCACTGTAAGTTGCCCTTCTATTAGCAGCCAAGGAAAAGGGAAACATGAGCTTATCCAGAACGGTGGCAGAGTCTCCTT
GGCAATCAACCAACGTTGCTATGAAATATGCCTCACACTGTATAGCTCATTATAGGACGTCAGGTTTGTTGAAAAAAGTGGGCAAGACAT

>55006_55006_3_MRPL33-GPN1_MRPL33_chr2_27997397_ENST00000296102_GPN1_chr2_27870703_ENST00000424214_length(amino acids)=132AA_BP=67
MLLVGGLLAGDGDCPGVVTMFLSAVFFAKSKSKNILVRMVSEAGTGFCFNTKRNRLREKLTLLHYDPVDSLSPVLHPSDLILTRGTLDEE

--------------------------------------------------------------
>55006_55006_4_MRPL33-GPN1_MRPL33_chr2_27997397_ENST00000296102_GPN1_chr2_27870703_ENST00000458167_length(transcript)=1047nt_BP=209nt
GCAGTTGTTGTTGGTTGGGGGCCTTTTGGCCGGTGACGGAGACTGCCCAGGTGTGGTCACCATGTTCCTCTCCGCGGTCTTCTTTGCCAA
GAGCAAGTCAAAAAACATTCTGGTGAGAATGGTGAGCGAAGCTGGGACAGGTTTCTGCTTCAACACCAAGAGAAACCGACTGCGGGAAAA
ACTGACTCTTTTGCATTATGATCCAGTTGACAGCTTATCTCCTGTGCTGCACCCTTCTGATTTGATCCTGACTCGAGGAACCTTGGATGA
AGAGGATGAGGAAGCAGACAGCGATACTGATGACATTGACCACAGAGTTACAGAGGAAAGCCATGAAGAGCCAGCATTCCAGAATTTTAT
GCAAGAATCGATGGCACAATACTGGAAGAGAAACAATAAATAGGAGACTTTAGCACACTTCACTTGTTTCTAGAAGTCCAGAATTTTGGA
CCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGGGGCTCCCATAAGGGATAATTTTCCTCAGAGTAGCAAAGTTTCTCTTATTAGA
GAAATCTTGTGACTCAGATGAAGTCAGGGATAGAAGACCCTTGGACCTGGCAGGTTAATGCTGATTATTCCTTGGCCTTTCCCTTGTATT
TATGCAAGGAAGGATATACTGAGCTGATACTCTTCCAAGCCTACAACTTCAAGTTTTATCATTTGAACTCAAGTACTTTTGCTGCTGAGG
AATGGAATCAAAAGAACGTAGTCTCCTGGTGACCACCTCAGATCTCTATTATTAGGCTAGATGTATAGCCTCTACTCCCCCAGCTTCTTG
CTCTTGACCCTGCACTGTAAGTTGCCCTTCTATTAGCAGCCAAGGAAAAGGGAAACATGAGCTTATCCAGAACGGTGGCAGAGTCTCCTT
GGCAATCAACCAACGTTGCTATGAAATATGCCTCACACTGTATAGCTCATTATAGGACGTCAGGTTTGTTGAAAAAAGTGGGCAAGACAT

>55006_55006_4_MRPL33-GPN1_MRPL33_chr2_27997397_ENST00000296102_GPN1_chr2_27870703_ENST00000458167_length(amino acids)=132AA_BP=67
MLLVGGLLAGDGDCPGVVTMFLSAVFFAKSKSKNILVRMVSEAGTGFCFNTKRNRLREKLTLLHYDPVDSLSPVLHPSDLILTRGTLDEE

--------------------------------------------------------------
>55006_55006_5_MRPL33-GPN1_MRPL33_chr2_27997397_ENST00000296102_GPN1_chr2_27870703_ENST00000503738_length(transcript)=412nt_BP=209nt
GCAGTTGTTGTTGGTTGGGGGCCTTTTGGCCGGTGACGGAGACTGCCCAGGTGTGGTCACCATGTTCCTCTCCGCGGTCTTCTTTGCCAA
GAGCAAGTCAAAAAACATTCTGGTGAGAATGGTGAGCGAAGCTGGGACAGGTTTCTGCTTCAACACCAAGAGAAACCGACTGCGGGAAAA
ACTGACTCTTTTGCATTATGATCCAGTTGACAGCTTATCTCCTGTGCTGCACCCTTCTGATTTGATCCTGACTCGAGGAACCTTGGATGA
AGAGGATGAGGAAGCAGACAGCGATACTGATGACATTGACCACAGAGTTACAGAGGAAAGCCATGAAGAGCCAGCATTCCAGAATTTTAT

>55006_55006_5_MRPL33-GPN1_MRPL33_chr2_27997397_ENST00000296102_GPN1_chr2_27870703_ENST00000503738_length(amino acids)=132AA_BP=67
MLLVGGLLAGDGDCPGVVTMFLSAVFFAKSKSKNILVRMVSEAGTGFCFNTKRNRLREKLTLLHYDPVDSLSPVLHPSDLILTRGTLDEE

--------------------------------------------------------------
>55006_55006_6_MRPL33-GPN1_MRPL33_chr2_27997397_ENST00000296102_GPN1_chr2_27870703_ENST00000515877_length(transcript)=566nt_BP=209nt
GCAGTTGTTGTTGGTTGGGGGCCTTTTGGCCGGTGACGGAGACTGCCCAGGTGTGGTCACCATGTTCCTCTCCGCGGTCTTCTTTGCCAA
GAGCAAGTCAAAAAACATTCTGGTGAGAATGGTGAGCGAAGCTGGGACAGGTTTCTGCTTCAACACCAAGAGAAACCGACTGCGGGAAAA
ACTGACTCTTTTGCATTATGATCCAGTTGACAGCTTATCTCCTGTGCTGCACCCTTCTGATTTGATCCTGACTCGAGGAACCTTGGATGA
AGAGGATGAGGAAGCAGACAGCGATACTGATGACATTGACCACAGAGTTACAGAGGAAAGCCATGAAGAGCCAGCATTCCAGAATTTTAT
GCAAGAATCGATGGCACAATACTGGAAGAGAAACAATAAATAGGAGACTTTAGCACACTTCACTTGTTTCTAGAAGTCCAGAATTTTGGA
CCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGGGGCTCCCATAAGGGATAATTTTCCTCAGAGTAGCAAAGTTTCTCTTATTAGA

>55006_55006_6_MRPL33-GPN1_MRPL33_chr2_27997397_ENST00000296102_GPN1_chr2_27870703_ENST00000515877_length(amino acids)=132AA_BP=67
MLLVGGLLAGDGDCPGVVTMFLSAVFFAKSKSKNILVRMVSEAGTGFCFNTKRNRLREKLTLLHYDPVDSLSPVLHPSDLILTRGTLDEE

--------------------------------------------------------------
>55006_55006_7_MRPL33-GPN1_MRPL33_chr2_27997397_ENST00000296102_GPN1_chr2_27870703_ENST00000610189_length(transcript)=1049nt_BP=209nt
GCAGTTGTTGTTGGTTGGGGGCCTTTTGGCCGGTGACGGAGACTGCCCAGGTGTGGTCACCATGTTCCTCTCCGCGGTCTTCTTTGCCAA
GAGCAAGTCAAAAAACATTCTGGTGAGAATGGTGAGCGAAGCTGGGACAGGTTTCTGCTTCAACACCAAGAGAAACCGACTGCGGGAAAA
ACTGACTCTTTTGCATTATGATCCAGTTGACAGCTTATCTCCTGTGCTGCACCCTTCTGATTTGATCCTGACTCGAGGAACCTTGGATGA
AGAGGATGAGGAAGCAGACAGCGATACTGATGACATTGACCACAGAGTTACAGAGGAAAGCCATGAAGAGCCAGCATTCCAGAATTTTAT
GCAAGAATCGATGGCACAATACTGGAAGAGAAACAATAAATAGGAGACTTTAGCACACTTCACTTGTTTCTAGAAGTCCAGAATTTTGGA
CCTCCACGTGAAAGAACTGTTCTTACCTCTGAACTGGGGGCTCCCATAAGGGATAATTTTCCTCAGAGTAGCAAAGTTTCTCTTATTAGA
GAAATCTTGTGACTCAGATGAAGTCAGGGATAGAAGACCCTTGGACCTGGCAGGTTAATGCTGATTATTCCTTGGCCTTTCCCTTGTATT
TATGCAAGGAAGGATATACTGAGCTGATACTCTTCCAAGCCTACAACTTCAAGTTTTATCATTTGAACTCAAGTACTTTTGCTGCTGAGG
AATGGAATCAAAAGAACGTAGTCTCCTGGTGACCACCTCAGATCTCTATTATTAGGCTAGATGTATAGCCTCTACTCCCCCAGCTTCTTG
CTCTTGACCCTGCACTGTAAGTTGCCCTTCTATTAGCAGCCAAGGAAAAGGGAAACATGAGCTTATCCAGAACGGTGGCAGAGTCTCCTT
GGCAATCAACCAACGTTGCTATGAAATATGCCTCACACTGTATAGCTCATTATAGGACGTCAGGTTTGTTGAAAAAAGTGGGCAAGACAT

>55006_55006_7_MRPL33-GPN1_MRPL33_chr2_27997397_ENST00000296102_GPN1_chr2_27870703_ENST00000610189_length(amino acids)=132AA_BP=67
MLLVGGLLAGDGDCPGVVTMFLSAVFFAKSKSKNILVRMVSEAGTGFCFNTKRNRLREKLTLLHYDPVDSLSPVLHPSDLILTRGTLDEE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MRPL33-GPN1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MRPL33-GPN1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MRPL33-GPN1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source