Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MRPL35-ADK (FusionGDB2 ID:55014)

Fusion Gene Summary for MRPL35-ADK

Fusion gene summary

Fusion gene information	Fusion gene name: MRPL35-ADK
	Fusion gene ID: 55014
		Hgene	Tgene
	Gene symbol	MRPL35	ADK
	Gene ID	51318	132
	Gene name	mitochondrial ribosomal protein L35	adenosine kinase
	Synonyms	L35mt\|MRP-L35	AK
	Cytomap	2p11.2	10q22.2\|10q11-q24
	Type of gene	protein-coding	protein-coding
	Description	39S ribosomal protein L35, mitochondrialmitochondrial large ribosomal subunit protein bL35m	adenosine kinaseadenosine 5'-phosphotransferasetesticular tissue protein Li 14
	Modification date	20200313	20200313
	UniProtAcc	Q9NZE8	P55263
	Ensembl transtripts involved in fusion gene	ENST00000605125, ENST00000254644, ENST00000337109, ENST00000409180,	ENST00000286621, ENST00000372734, ENST00000539909, ENST00000541550, ENST00000467840,
Fusion gene scores	* DoF score	10 X 8 X 4=320	30 X 17 X 14=7140
	# samples	10	64
	** MAII score	log2(10/320*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(64/7140*10)=-3.4797802640291 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MRPL35 [Title/Abstract] AND ADK [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MRPL35(86437736)-ADK(76349039), # samples:2
Anticipated loss of major functional domain due to fusion event.	MRPL35-ADK seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. MRPL35-ADK seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. MRPL35-ADK seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MRPL35 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ADK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-HU-A4GY	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+

Top

Fusion Gene ORF analysis for MRPL35-ADK

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000605125	ENST00000286621	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+
3UTR-3CDS	ENST00000605125	ENST00000372734	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+
3UTR-3CDS	ENST00000605125	ENST00000539909	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+
3UTR-3CDS	ENST00000605125	ENST00000541550	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+
3UTR-intron	ENST00000605125	ENST00000467840	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+
5CDS-intron	ENST00000254644	ENST00000467840	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+
5CDS-intron	ENST00000337109	ENST00000467840	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+
5CDS-intron	ENST00000409180	ENST00000467840	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+
Frame-shift	ENST00000254644	ENST00000286621	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+
Frame-shift	ENST00000254644	ENST00000372734	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+
Frame-shift	ENST00000254644	ENST00000539909	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+
Frame-shift	ENST00000254644	ENST00000541550	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+
Frame-shift	ENST00000409180	ENST00000286621	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+
Frame-shift	ENST00000409180	ENST00000372734	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+
Frame-shift	ENST00000409180	ENST00000539909	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+
Frame-shift	ENST00000409180	ENST00000541550	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+
In-frame	ENST00000337109	ENST00000286621	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+
In-frame	ENST00000337109	ENST00000372734	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+
In-frame	ENST00000337109	ENST00000539909	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+
In-frame	ENST00000337109	ENST00000541550	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000337109

MRPL35

chr2

86437736

ENST00000539909

ADK

chr10

76349039

4210

3593

2611

2114

165

ENST00000337109

MRPL35

chr2

86437736

ENST00000286621

ADK

chr10

76349039

3986

3593

2611

2114

165

ENST00000337109

MRPL35

chr2

86437736

ENST00000372734

ADK

chr10

76349039

4814

3593

2611

2114

165

ENST00000337109

MRPL35

chr2

86437736

ENST00000541550

ADK

chr10

76349039

4049

3593

2611

2114

165

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000337109	ENST00000539909	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+	0.14222784	0.8577722
ENST00000337109	ENST00000286621	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+	0.26345548	0.73654455
ENST00000337109	ENST00000372734	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+	0.39274532	0.6072547
ENST00000337109	ENST00000541550	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+	0.23510435	0.7648956

Top

Fusion Genomic Features for MRPL35-ADK

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for MRPL35-ADK

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:86437736/chr10:76349039)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MRPL35 Q9NZE8	ADK P55263
	FUNCTION: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ADK

chr2:86437736

chr10:76349039

ENST00000286621

8_16

242

363.0

Motif

Nuclear localization signal

Tgene

ADK

chr2:86437736

chr10:76349039

ENST00000372734

8_16

225

346.0

Motif

Nuclear localization signal

Tgene

ADK

chr2:86437736

chr10:76349039

ENST00000539909

8_16

185

306.0

Motif

Nuclear localization signal

Tgene

ADK

chr2:86437736

chr10:76349039

ENST00000541550

8_16

207

328.0

Motif

Nuclear localization signal

Top

Fusion Gene Sequence for MRPL35-ADK

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>55014_55014_1_MRPL35-ADK_MRPL35_chr2_86437736_ENST00000337109_ADK_chr10_76349039_ENST00000286621_length(transcript)=3986nt_BP=3593nt
AAACCCAAAGCGGCCGCCGTAGGCGAAGGTGAAGATGGCTGCCTCTGCCTTTGCTGGTGCAGTGAGAGCAGCTTCAGGAATCCTACGGCC
CCTGAATATTTTGGCATCTTCAACCTACCGCAACTGTGTCAAGAATGCCTCTCTTATTTCTGCATTGTCCACTGGACGTTTTAGTCATAT
TCAGACACCAGTTGTTTCCTCCACTCCCAGACTTACCACATCTGAGAGAAACCTGACATGTGGGCATACCTCAGTGATCCTTAATAGAAT
GGCCCCCGTGCTTCCAAGTGTCCTGAAGCTGCCAGTCAGATCTCTAACATACTTCAGTGCAAGAAAAGGCAAGAGAAAGACCGTGAAAGC
TGTCATCGATAGGTTTCTTCGACTTCATTGTGGCCTTTGGGTGAGGAGAAAGGTACGTTGATGATCCTTATCAGAAGTATCATGATCGAA
CAAACCTGAAAGTATAGATCAGAAGTTTCACTTGTTTCTCAGTTATTGGATATGTATCTTTGTGTACATATCTTTGCAAAAATGGATAAG
TACAAAACTTGATGTAAATTGTACCAATGAATACGTAAACATACAGTGACAACATTAAACTTAGAAAAGTTTTAAAACTTAATGGATCAG
ACTTTGCCAGATTTGGTTAGGGAAACAGAAATTTAGAATGGTGCATTATTTTTAACAAATGGTATTGGCTTAACTAGTTGTTTCAGTTAT
GCTCTTTTAGTTGCAAGGAATCTCAAGTGGGACAAACATAAAAAGACTCAAAAGCTACAAGTTAGCTCAAGCAATGTGACATTATTTCAA
GGATATGTGCCAGGGAATTCAGGAACCACCTCACCAACCCCATCTCCCACTCAGAAATCACCTCCCAGCCTCAGGAAGAGTAGAAATTGG
GTGGTGCTCCTCAGCAGGGGAAGGTGGATGTTTAGGCTTGGGCTCTGCATGCATGTGACTTGCTTCTTTTTGCATTGTTAACTCCATTCT
CTCTATTCACCAACTTCTCTACACAGCTTTTGCATACTTACAGTTTCTGTTCCTTTGTAATAACTTTAACTTGCACCTTTGAGGTTCTTT
TCTACATGATGACCTTCAGCTCCTGCTGCTAGTCTCCAATTGCCAAGGGAATTTAACTGGGCCAGACTACCTTTTTATACTAGGTCTGGT
TGGGTCATTGTCTAGAGTAGGGATTGGCTGTCCTTAAGTCAGGAGCCCGCTTTGTATTAGCAGGTTTGCATGCAGCAAAAAAACAGTTAT
GTGAGCAGTTTCACTTGGAGGTTCACATGGGGTGGCAGCACACTTAACATCTAACACACCAGGTTCATTGTGTTCATAACACTTGTCATT
TACTGTAACAACATTTTTTCATAGGAGAGTAAATAGCCCTTCAGCATGCTCATTCATGAAACAGAAGAGGCTGTACAAGTGAAGACAAGG
GCTTTTTATGCAAGTTTTGAAAGATAGGTATTTATTTTTTCTAGAGACAGGAGTTTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCA
ATCATAGCTCATTGAAGCCTCGCACTCCTGGGCTCAAGTGGTCCTCCTGCCTCAGCTTACTGAGTAAGGATATGTATTTCTTAAAAGTTA
GTTTATCCACTTCAGATTTCATGTTTTCATTTGTAAGGATAAACTTTTCCCACAAATTTTCAACAATCATTGTAGAAACTAAGGGGGAGA
AAGTAATCTCAGTTGTTTTAGAAACGAAAAAGTTAAGCATTGTTTACTTGAAGTGGGCAGGGAAGCAGCACTGAGTAAAGTTCAATTGAG
TGGTTACAGTCTAGGGCAGTGGTTCCCAACTCTCCGATCAGAATCATCTGGGAAGCATTTTCAAACAGCAAAGTACTTTGAAAACCATTA
TTAAATAGAATTATGCATGAATTACTGTTTCAGATCCTTTAATGTGGTAGTTGGTAATAATAAGATGAAATTCCTCTGTTGTTAGTAAAA
TTATGAAATTGAAGTTCTGCAGCATGTCAGGCCAGGATTATTAGGGAGATTCCTCGAAACTAGTGTGTGTTTATTAAAAGGAGAAAGGAT
AACAATAGAATGTTCTAAAACCAGAAGTCCAAGTGCGTGTCTACTTATGGGACCAATAAATAAAGAACAGACATTTGATTTGAGGTGAGG
TAAAAGCCTGAAACATGGAATGGCATTCTGTTTTGATGGATTTTCATTTCTTCGCACTTCTGAGACGGCAAAGCCAACCACTTAGAAGCC
TTCCACATCTTTGTCACCTGCCTGGCTCCTGCTCTCTGATGTACCTCTGGGTAGTGAGATGGAAATGGTGCCTGCAGAAGTTGGGGAGAA
GGATACTTTTGCACAGCCTCCATGATGTCTTTATTGCAAATATGGATGACAAGGGTCTCTGTTACAGGGGCCTCAGAGCACCTTCGTTTC
TCCTCTAGACCAGGGACAGGTGTAGAGATAAGGACTGGCAACCAGAGCCTCAGCATCCAAAGATGGACTGAAGTGGGATGGCTGACAGGC
ACATAACTTACGGGAAAGGGAATTTCATACATACGATTTTTGTTTTGTGGGTAGGAGGGCTTATCATCAACACTGATTTTATAATCTGAC
AATAAATGTCTTTCATTAAAGAGTTTACCTAAATGATGTTCGATTATATGTATAATTTATAAAATATTTATGTATAGTTTGTTTATTCAG
GTATATGTATAATTTATTGAACACCTACTATGTCCCAGCATATCTACAAAACTGGGTACATACATACTGTCTAACTGCTAATCCACATTT
CCAGTCTTACAAAGGACATAATGATTAGTTAAGCCCTAATTTAGATTTGAGGAAACTGAAGCTGAGAGAGGGTTAAGTAAATTACCCAAA
GTACAGCTAATAAGACCCAGAATCTCAGTCTCACTCCTTGGGATCCTGTGTATTTCCCTGAGTCTTCTAACATATGAAAATTCATATCTA
AATCAACAAGTGACTGTAATCTGGTACTATAAATACTAAATAAACACTTCTTCATAACACTGTACCAATTCAGCTTTTAAATTTTATTAC
TTTGCTTTCCTGTCCTTTGCCAACTCTTAACCTAGTTAATCCTAGTTCTGTTGACATTGGACCAGGCTCAGTAAATAAACGAATGGATTT
CCAGCCTTTTTTTCCCATCTGTTCCTGCTTTTAGTCCTCTGAATCTGCTTCTTTTCTTACTGCTGCTTTATTTTACAGTGATTTTGTCAA
ACATAGAATACAGGACTAAAAATGCAAAGAAATTGGGTCTGTGTTTAATTTTGATGTTTCAAATTTTGAGCTTCCAAGTCTTTGTGGCCA
CCCAATGAAGTTTGAGTCTGCCTGTTCAGATGTGAAAGGTAAGGGCTGCAGCAGGTTTAAGGGTGGCCCTTCACCACCCTGTTGTCACCT
GCACAGGCACTCCCCCATTTGCAGATGAAGAAATGTTCAGAGAAGAAAAATGATGGACCAAACGTCTGTTTGCACAATTGAAACTCTACC
AGTGGACTATTCTATTTTCACAGCTACCTAGTTTCTGCCGATGATTTTTTTAAATGTGAAATAAACAGTGATACTTTCAGGTTGAAGCTG
CCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGACATTAAAGAGATAGCCAAAAAGACACAAGCCCTGCCAAAGATGAACTCAAAGA
GGCAGCGAATCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACAGAAAGTGAAGTCACTGCTTTTGCTGTCTTGGATCAAG
ACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGATGCATTTGTTGGAGGTTTTCTGTCTCAACTGGTCTCTGACAAGCCTCTGACTG
AATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTTTCCTGAGAAGCCAGACTTCCACTGATGGA

>55014_55014_1_MRPL35-ADK_MRPL35_chr2_86437736_ENST00000337109_ADK_chr10_76349039_ENST00000286621_length(amino acids)=165AA_BP=
MSDYKISVDDKPSYPQNKNRMYEIPFPVSYVPVSHPTSVHLWMLRLWLPVLISTPVPGLEEKRRCSEAPVTETLVIHICNKDIMEAVQKY

--------------------------------------------------------------
>55014_55014_2_MRPL35-ADK_MRPL35_chr2_86437736_ENST00000337109_ADK_chr10_76349039_ENST00000372734_length(transcript)=4814nt_BP=3593nt
AAACCCAAAGCGGCCGCCGTAGGCGAAGGTGAAGATGGCTGCCTCTGCCTTTGCTGGTGCAGTGAGAGCAGCTTCAGGAATCCTACGGCC
CCTGAATATTTTGGCATCTTCAACCTACCGCAACTGTGTCAAGAATGCCTCTCTTATTTCTGCATTGTCCACTGGACGTTTTAGTCATAT
TCAGACACCAGTTGTTTCCTCCACTCCCAGACTTACCACATCTGAGAGAAACCTGACATGTGGGCATACCTCAGTGATCCTTAATAGAAT
GGCCCCCGTGCTTCCAAGTGTCCTGAAGCTGCCAGTCAGATCTCTAACATACTTCAGTGCAAGAAAAGGCAAGAGAAAGACCGTGAAAGC
TGTCATCGATAGGTTTCTTCGACTTCATTGTGGCCTTTGGGTGAGGAGAAAGGTACGTTGATGATCCTTATCAGAAGTATCATGATCGAA
CAAACCTGAAAGTATAGATCAGAAGTTTCACTTGTTTCTCAGTTATTGGATATGTATCTTTGTGTACATATCTTTGCAAAAATGGATAAG
TACAAAACTTGATGTAAATTGTACCAATGAATACGTAAACATACAGTGACAACATTAAACTTAGAAAAGTTTTAAAACTTAATGGATCAG
ACTTTGCCAGATTTGGTTAGGGAAACAGAAATTTAGAATGGTGCATTATTTTTAACAAATGGTATTGGCTTAACTAGTTGTTTCAGTTAT
GCTCTTTTAGTTGCAAGGAATCTCAAGTGGGACAAACATAAAAAGACTCAAAAGCTACAAGTTAGCTCAAGCAATGTGACATTATTTCAA
GGATATGTGCCAGGGAATTCAGGAACCACCTCACCAACCCCATCTCCCACTCAGAAATCACCTCCCAGCCTCAGGAAGAGTAGAAATTGG
GTGGTGCTCCTCAGCAGGGGAAGGTGGATGTTTAGGCTTGGGCTCTGCATGCATGTGACTTGCTTCTTTTTGCATTGTTAACTCCATTCT
CTCTATTCACCAACTTCTCTACACAGCTTTTGCATACTTACAGTTTCTGTTCCTTTGTAATAACTTTAACTTGCACCTTTGAGGTTCTTT
TCTACATGATGACCTTCAGCTCCTGCTGCTAGTCTCCAATTGCCAAGGGAATTTAACTGGGCCAGACTACCTTTTTATACTAGGTCTGGT
TGGGTCATTGTCTAGAGTAGGGATTGGCTGTCCTTAAGTCAGGAGCCCGCTTTGTATTAGCAGGTTTGCATGCAGCAAAAAAACAGTTAT
GTGAGCAGTTTCACTTGGAGGTTCACATGGGGTGGCAGCACACTTAACATCTAACACACCAGGTTCATTGTGTTCATAACACTTGTCATT
TACTGTAACAACATTTTTTCATAGGAGAGTAAATAGCCCTTCAGCATGCTCATTCATGAAACAGAAGAGGCTGTACAAGTGAAGACAAGG
GCTTTTTATGCAAGTTTTGAAAGATAGGTATTTATTTTTTCTAGAGACAGGAGTTTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCA
ATCATAGCTCATTGAAGCCTCGCACTCCTGGGCTCAAGTGGTCCTCCTGCCTCAGCTTACTGAGTAAGGATATGTATTTCTTAAAAGTTA
GTTTATCCACTTCAGATTTCATGTTTTCATTTGTAAGGATAAACTTTTCCCACAAATTTTCAACAATCATTGTAGAAACTAAGGGGGAGA
AAGTAATCTCAGTTGTTTTAGAAACGAAAAAGTTAAGCATTGTTTACTTGAAGTGGGCAGGGAAGCAGCACTGAGTAAAGTTCAATTGAG
TGGTTACAGTCTAGGGCAGTGGTTCCCAACTCTCCGATCAGAATCATCTGGGAAGCATTTTCAAACAGCAAAGTACTTTGAAAACCATTA
TTAAATAGAATTATGCATGAATTACTGTTTCAGATCCTTTAATGTGGTAGTTGGTAATAATAAGATGAAATTCCTCTGTTGTTAGTAAAA
TTATGAAATTGAAGTTCTGCAGCATGTCAGGCCAGGATTATTAGGGAGATTCCTCGAAACTAGTGTGTGTTTATTAAAAGGAGAAAGGAT
AACAATAGAATGTTCTAAAACCAGAAGTCCAAGTGCGTGTCTACTTATGGGACCAATAAATAAAGAACAGACATTTGATTTGAGGTGAGG
TAAAAGCCTGAAACATGGAATGGCATTCTGTTTTGATGGATTTTCATTTCTTCGCACTTCTGAGACGGCAAAGCCAACCACTTAGAAGCC
TTCCACATCTTTGTCACCTGCCTGGCTCCTGCTCTCTGATGTACCTCTGGGTAGTGAGATGGAAATGGTGCCTGCAGAAGTTGGGGAGAA
GGATACTTTTGCACAGCCTCCATGATGTCTTTATTGCAAATATGGATGACAAGGGTCTCTGTTACAGGGGCCTCAGAGCACCTTCGTTTC
TCCTCTAGACCAGGGACAGGTGTAGAGATAAGGACTGGCAACCAGAGCCTCAGCATCCAAAGATGGACTGAAGTGGGATGGCTGACAGGC
ACATAACTTACGGGAAAGGGAATTTCATACATACGATTTTTGTTTTGTGGGTAGGAGGGCTTATCATCAACACTGATTTTATAATCTGAC
AATAAATGTCTTTCATTAAAGAGTTTACCTAAATGATGTTCGATTATATGTATAATTTATAAAATATTTATGTATAGTTTGTTTATTCAG
GTATATGTATAATTTATTGAACACCTACTATGTCCCAGCATATCTACAAAACTGGGTACATACATACTGTCTAACTGCTAATCCACATTT
CCAGTCTTACAAAGGACATAATGATTAGTTAAGCCCTAATTTAGATTTGAGGAAACTGAAGCTGAGAGAGGGTTAAGTAAATTACCCAAA
GTACAGCTAATAAGACCCAGAATCTCAGTCTCACTCCTTGGGATCCTGTGTATTTCCCTGAGTCTTCTAACATATGAAAATTCATATCTA
AATCAACAAGTGACTGTAATCTGGTACTATAAATACTAAATAAACACTTCTTCATAACACTGTACCAATTCAGCTTTTAAATTTTATTAC
TTTGCTTTCCTGTCCTTTGCCAACTCTTAACCTAGTTAATCCTAGTTCTGTTGACATTGGACCAGGCTCAGTAAATAAACGAATGGATTT
CCAGCCTTTTTTTCCCATCTGTTCCTGCTTTTAGTCCTCTGAATCTGCTTCTTTTCTTACTGCTGCTTTATTTTACAGTGATTTTGTCAA
ACATAGAATACAGGACTAAAAATGCAAAGAAATTGGGTCTGTGTTTAATTTTGATGTTTCAAATTTTGAGCTTCCAAGTCTTTGTGGCCA
CCCAATGAAGTTTGAGTCTGCCTGTTCAGATGTGAAAGGTAAGGGCTGCAGCAGGTTTAAGGGTGGCCCTTCACCACCCTGTTGTCACCT
GCACAGGCACTCCCCCATTTGCAGATGAAGAAATGTTCAGAGAAGAAAAATGATGGACCAAACGTCTGTTTGCACAATTGAAACTCTACC
AGTGGACTATTCTATTTTCACAGCTACCTAGTTTCTGCCGATGATTTTTTTAAATGTGAAATAAACAGTGATACTTTCAGGTTGAAGCTG
CCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGACATTAAAGAGATAGCCAAAAAGACACAAGCCCTGCCAAAGATGAACTCAAAGA
GGCAGCGAATCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACAGAAAGTGAAGTCACTGCTTTTGCTGTCTTGGATCAAG
ACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGATGCATTTGTTGGAGGTTTTCTGTCTCAACTGGTCTCTGACAAGCCTCTGACTG
AATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTTTCCTGAGAAGCCAGACTTCCACTGATGGA
AGAGCTGAAAACACAAGCCCAGGAGTGCAGACACTGCCCTAATTGCTTCCTGAGAATTCCCATATTAATAAAGAAGAAAATTATCTGCCA
TTTTTTCCTACTATAATAATGCTGAATCTTAATTTAGAGGGTACAAGGGTATGGTAATGCTTGTAGAATCTTTATTATCTCAACAATCTA
AAAAATGATGTTTATTTCCATAGTTTGATAGTGCCACTTAAATGCCAATTAAACAAGAATATAACATTTCAATAGAAATTTTTATTTCAT
TTTCAATTACTTTGTAAATTCGTGTGTATTTAGTACACTGATTTGTTTTTTTACATTTCTGCTTTGAATGCAGATGCAATTTAATATAAT
AGATTTTTTAATGAATTAATCTTAACATAGTAATCTTTAGCTTTTTATACAAATATATTTAATTTAGGAGTATATGTGTGTCTATACACA
CACATACATAAATATACCACATATACACCTGATAGTCAAATAAGGTACAGAAATTTTATCTTGTCAATTATGCCAAATAATCTCTTTAAT
GTGCACTCAAACATGTAATAAACTTTGGATAATTAAATAATGTGCCAAATTTAAGTTGTACCACAATATTCAAATCATAGTCTTATGGAA
CTCTGTAATTGGACACAAACAAAAACTTGTCATATAGGAATTTTTTTCTGTCTTTTCCCTGTGTACAGCAAACTGAGGAAGAAAGATCAT
TATTTAATACTGGGCCCTGAAATGACACCCAATTTGTTAATGGAATTATGAAGAACAGCAATATAATACACTGAAGAATAACTTAGTATC

>55014_55014_2_MRPL35-ADK_MRPL35_chr2_86437736_ENST00000337109_ADK_chr10_76349039_ENST00000372734_length(amino acids)=165AA_BP=
MSDYKISVDDKPSYPQNKNRMYEIPFPVSYVPVSHPTSVHLWMLRLWLPVLISTPVPGLEEKRRCSEAPVTETLVIHICNKDIMEAVQKY

--------------------------------------------------------------
>55014_55014_3_MRPL35-ADK_MRPL35_chr2_86437736_ENST00000337109_ADK_chr10_76349039_ENST00000539909_length(transcript)=4210nt_BP=3593nt
AAACCCAAAGCGGCCGCCGTAGGCGAAGGTGAAGATGGCTGCCTCTGCCTTTGCTGGTGCAGTGAGAGCAGCTTCAGGAATCCTACGGCC
CCTGAATATTTTGGCATCTTCAACCTACCGCAACTGTGTCAAGAATGCCTCTCTTATTTCTGCATTGTCCACTGGACGTTTTAGTCATAT
TCAGACACCAGTTGTTTCCTCCACTCCCAGACTTACCACATCTGAGAGAAACCTGACATGTGGGCATACCTCAGTGATCCTTAATAGAAT
GGCCCCCGTGCTTCCAAGTGTCCTGAAGCTGCCAGTCAGATCTCTAACATACTTCAGTGCAAGAAAAGGCAAGAGAAAGACCGTGAAAGC
TGTCATCGATAGGTTTCTTCGACTTCATTGTGGCCTTTGGGTGAGGAGAAAGGTACGTTGATGATCCTTATCAGAAGTATCATGATCGAA
CAAACCTGAAAGTATAGATCAGAAGTTTCACTTGTTTCTCAGTTATTGGATATGTATCTTTGTGTACATATCTTTGCAAAAATGGATAAG
TACAAAACTTGATGTAAATTGTACCAATGAATACGTAAACATACAGTGACAACATTAAACTTAGAAAAGTTTTAAAACTTAATGGATCAG
ACTTTGCCAGATTTGGTTAGGGAAACAGAAATTTAGAATGGTGCATTATTTTTAACAAATGGTATTGGCTTAACTAGTTGTTTCAGTTAT
GCTCTTTTAGTTGCAAGGAATCTCAAGTGGGACAAACATAAAAAGACTCAAAAGCTACAAGTTAGCTCAAGCAATGTGACATTATTTCAA
GGATATGTGCCAGGGAATTCAGGAACCACCTCACCAACCCCATCTCCCACTCAGAAATCACCTCCCAGCCTCAGGAAGAGTAGAAATTGG
GTGGTGCTCCTCAGCAGGGGAAGGTGGATGTTTAGGCTTGGGCTCTGCATGCATGTGACTTGCTTCTTTTTGCATTGTTAACTCCATTCT
CTCTATTCACCAACTTCTCTACACAGCTTTTGCATACTTACAGTTTCTGTTCCTTTGTAATAACTTTAACTTGCACCTTTGAGGTTCTTT
TCTACATGATGACCTTCAGCTCCTGCTGCTAGTCTCCAATTGCCAAGGGAATTTAACTGGGCCAGACTACCTTTTTATACTAGGTCTGGT
TGGGTCATTGTCTAGAGTAGGGATTGGCTGTCCTTAAGTCAGGAGCCCGCTTTGTATTAGCAGGTTTGCATGCAGCAAAAAAACAGTTAT
GTGAGCAGTTTCACTTGGAGGTTCACATGGGGTGGCAGCACACTTAACATCTAACACACCAGGTTCATTGTGTTCATAACACTTGTCATT
TACTGTAACAACATTTTTTCATAGGAGAGTAAATAGCCCTTCAGCATGCTCATTCATGAAACAGAAGAGGCTGTACAAGTGAAGACAAGG
GCTTTTTATGCAAGTTTTGAAAGATAGGTATTTATTTTTTCTAGAGACAGGAGTTTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCA
ATCATAGCTCATTGAAGCCTCGCACTCCTGGGCTCAAGTGGTCCTCCTGCCTCAGCTTACTGAGTAAGGATATGTATTTCTTAAAAGTTA
GTTTATCCACTTCAGATTTCATGTTTTCATTTGTAAGGATAAACTTTTCCCACAAATTTTCAACAATCATTGTAGAAACTAAGGGGGAGA
AAGTAATCTCAGTTGTTTTAGAAACGAAAAAGTTAAGCATTGTTTACTTGAAGTGGGCAGGGAAGCAGCACTGAGTAAAGTTCAATTGAG
TGGTTACAGTCTAGGGCAGTGGTTCCCAACTCTCCGATCAGAATCATCTGGGAAGCATTTTCAAACAGCAAAGTACTTTGAAAACCATTA
TTAAATAGAATTATGCATGAATTACTGTTTCAGATCCTTTAATGTGGTAGTTGGTAATAATAAGATGAAATTCCTCTGTTGTTAGTAAAA
TTATGAAATTGAAGTTCTGCAGCATGTCAGGCCAGGATTATTAGGGAGATTCCTCGAAACTAGTGTGTGTTTATTAAAAGGAGAAAGGAT
AACAATAGAATGTTCTAAAACCAGAAGTCCAAGTGCGTGTCTACTTATGGGACCAATAAATAAAGAACAGACATTTGATTTGAGGTGAGG
TAAAAGCCTGAAACATGGAATGGCATTCTGTTTTGATGGATTTTCATTTCTTCGCACTTCTGAGACGGCAAAGCCAACCACTTAGAAGCC
TTCCACATCTTTGTCACCTGCCTGGCTCCTGCTCTCTGATGTACCTCTGGGTAGTGAGATGGAAATGGTGCCTGCAGAAGTTGGGGAGAA
GGATACTTTTGCACAGCCTCCATGATGTCTTTATTGCAAATATGGATGACAAGGGTCTCTGTTACAGGGGCCTCAGAGCACCTTCGTTTC
TCCTCTAGACCAGGGACAGGTGTAGAGATAAGGACTGGCAACCAGAGCCTCAGCATCCAAAGATGGACTGAAGTGGGATGGCTGACAGGC
ACATAACTTACGGGAAAGGGAATTTCATACATACGATTTTTGTTTTGTGGGTAGGAGGGCTTATCATCAACACTGATTTTATAATCTGAC
AATAAATGTCTTTCATTAAAGAGTTTACCTAAATGATGTTCGATTATATGTATAATTTATAAAATATTTATGTATAGTTTGTTTATTCAG
GTATATGTATAATTTATTGAACACCTACTATGTCCCAGCATATCTACAAAACTGGGTACATACATACTGTCTAACTGCTAATCCACATTT
CCAGTCTTACAAAGGACATAATGATTAGTTAAGCCCTAATTTAGATTTGAGGAAACTGAAGCTGAGAGAGGGTTAAGTAAATTACCCAAA
GTACAGCTAATAAGACCCAGAATCTCAGTCTCACTCCTTGGGATCCTGTGTATTTCCCTGAGTCTTCTAACATATGAAAATTCATATCTA
AATCAACAAGTGACTGTAATCTGGTACTATAAATACTAAATAAACACTTCTTCATAACACTGTACCAATTCAGCTTTTAAATTTTATTAC
TTTGCTTTCCTGTCCTTTGCCAACTCTTAACCTAGTTAATCCTAGTTCTGTTGACATTGGACCAGGCTCAGTAAATAAACGAATGGATTT
CCAGCCTTTTTTTCCCATCTGTTCCTGCTTTTAGTCCTCTGAATCTGCTTCTTTTCTTACTGCTGCTTTATTTTACAGTGATTTTGTCAA
ACATAGAATACAGGACTAAAAATGCAAAGAAATTGGGTCTGTGTTTAATTTTGATGTTTCAAATTTTGAGCTTCCAAGTCTTTGTGGCCA
CCCAATGAAGTTTGAGTCTGCCTGTTCAGATGTGAAAGGTAAGGGCTGCAGCAGGTTTAAGGGTGGCCCTTCACCACCCTGTTGTCACCT
GCACAGGCACTCCCCCATTTGCAGATGAAGAAATGTTCAGAGAAGAAAAATGATGGACCAAACGTCTGTTTGCACAATTGAAACTCTACC
AGTGGACTATTCTATTTTCACAGCTACCTAGTTTCTGCCGATGATTTTTTTAAATGTGAAATAAACAGTGATACTTTCAGGTTGAAGCTG
CCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGACATTAAAGAGATAGCCAAAAAGACACAAGCCCTGCCAAAGATGAACTCAAAGA
GGCAGCGAATCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACAGAAAGTGAAGTCACTGCTTTTGCTGTCTTGGATCAAG
ACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGATGCATTTGTTGGAGGTTTTCTGTCTCAACTGGTCTCTGACAAGCCTCTGACTG
AATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTTTCCTGAGAAGCCAGACTTCCACTGATGGA
AGAGCTGAAAACACAAGCCCAGGAGTGCAGACACTGCCCTAATTGCTTCCTGAGAATTCCCATATTAATAAAGAAGAAAATTATCTGCCA
TTTTTTCCTACTATAATAATGCTGAATCTTAATTTAGAGGGTACAAGGGTATGGTAATGCTTGTAGAATCTTTATTATCTCAACAATCTA

>55014_55014_3_MRPL35-ADK_MRPL35_chr2_86437736_ENST00000337109_ADK_chr10_76349039_ENST00000539909_length(amino acids)=165AA_BP=
MSDYKISVDDKPSYPQNKNRMYEIPFPVSYVPVSHPTSVHLWMLRLWLPVLISTPVPGLEEKRRCSEAPVTETLVIHICNKDIMEAVQKY

--------------------------------------------------------------
>55014_55014_4_MRPL35-ADK_MRPL35_chr2_86437736_ENST00000337109_ADK_chr10_76349039_ENST00000541550_length(transcript)=4049nt_BP=3593nt
AAACCCAAAGCGGCCGCCGTAGGCGAAGGTGAAGATGGCTGCCTCTGCCTTTGCTGGTGCAGTGAGAGCAGCTTCAGGAATCCTACGGCC
CCTGAATATTTTGGCATCTTCAACCTACCGCAACTGTGTCAAGAATGCCTCTCTTATTTCTGCATTGTCCACTGGACGTTTTAGTCATAT
TCAGACACCAGTTGTTTCCTCCACTCCCAGACTTACCACATCTGAGAGAAACCTGACATGTGGGCATACCTCAGTGATCCTTAATAGAAT
GGCCCCCGTGCTTCCAAGTGTCCTGAAGCTGCCAGTCAGATCTCTAACATACTTCAGTGCAAGAAAAGGCAAGAGAAAGACCGTGAAAGC
TGTCATCGATAGGTTTCTTCGACTTCATTGTGGCCTTTGGGTGAGGAGAAAGGTACGTTGATGATCCTTATCAGAAGTATCATGATCGAA
CAAACCTGAAAGTATAGATCAGAAGTTTCACTTGTTTCTCAGTTATTGGATATGTATCTTTGTGTACATATCTTTGCAAAAATGGATAAG
TACAAAACTTGATGTAAATTGTACCAATGAATACGTAAACATACAGTGACAACATTAAACTTAGAAAAGTTTTAAAACTTAATGGATCAG
ACTTTGCCAGATTTGGTTAGGGAAACAGAAATTTAGAATGGTGCATTATTTTTAACAAATGGTATTGGCTTAACTAGTTGTTTCAGTTAT
GCTCTTTTAGTTGCAAGGAATCTCAAGTGGGACAAACATAAAAAGACTCAAAAGCTACAAGTTAGCTCAAGCAATGTGACATTATTTCAA
GGATATGTGCCAGGGAATTCAGGAACCACCTCACCAACCCCATCTCCCACTCAGAAATCACCTCCCAGCCTCAGGAAGAGTAGAAATTGG
GTGGTGCTCCTCAGCAGGGGAAGGTGGATGTTTAGGCTTGGGCTCTGCATGCATGTGACTTGCTTCTTTTTGCATTGTTAACTCCATTCT
CTCTATTCACCAACTTCTCTACACAGCTTTTGCATACTTACAGTTTCTGTTCCTTTGTAATAACTTTAACTTGCACCTTTGAGGTTCTTT
TCTACATGATGACCTTCAGCTCCTGCTGCTAGTCTCCAATTGCCAAGGGAATTTAACTGGGCCAGACTACCTTTTTATACTAGGTCTGGT
TGGGTCATTGTCTAGAGTAGGGATTGGCTGTCCTTAAGTCAGGAGCCCGCTTTGTATTAGCAGGTTTGCATGCAGCAAAAAAACAGTTAT
GTGAGCAGTTTCACTTGGAGGTTCACATGGGGTGGCAGCACACTTAACATCTAACACACCAGGTTCATTGTGTTCATAACACTTGTCATT
TACTGTAACAACATTTTTTCATAGGAGAGTAAATAGCCCTTCAGCATGCTCATTCATGAAACAGAAGAGGCTGTACAAGTGAAGACAAGG
GCTTTTTATGCAAGTTTTGAAAGATAGGTATTTATTTTTTCTAGAGACAGGAGTTTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCA
ATCATAGCTCATTGAAGCCTCGCACTCCTGGGCTCAAGTGGTCCTCCTGCCTCAGCTTACTGAGTAAGGATATGTATTTCTTAAAAGTTA
GTTTATCCACTTCAGATTTCATGTTTTCATTTGTAAGGATAAACTTTTCCCACAAATTTTCAACAATCATTGTAGAAACTAAGGGGGAGA
AAGTAATCTCAGTTGTTTTAGAAACGAAAAAGTTAAGCATTGTTTACTTGAAGTGGGCAGGGAAGCAGCACTGAGTAAAGTTCAATTGAG
TGGTTACAGTCTAGGGCAGTGGTTCCCAACTCTCCGATCAGAATCATCTGGGAAGCATTTTCAAACAGCAAAGTACTTTGAAAACCATTA
TTAAATAGAATTATGCATGAATTACTGTTTCAGATCCTTTAATGTGGTAGTTGGTAATAATAAGATGAAATTCCTCTGTTGTTAGTAAAA
TTATGAAATTGAAGTTCTGCAGCATGTCAGGCCAGGATTATTAGGGAGATTCCTCGAAACTAGTGTGTGTTTATTAAAAGGAGAAAGGAT
AACAATAGAATGTTCTAAAACCAGAAGTCCAAGTGCGTGTCTACTTATGGGACCAATAAATAAAGAACAGACATTTGATTTGAGGTGAGG
TAAAAGCCTGAAACATGGAATGGCATTCTGTTTTGATGGATTTTCATTTCTTCGCACTTCTGAGACGGCAAAGCCAACCACTTAGAAGCC
TTCCACATCTTTGTCACCTGCCTGGCTCCTGCTCTCTGATGTACCTCTGGGTAGTGAGATGGAAATGGTGCCTGCAGAAGTTGGGGAGAA
GGATACTTTTGCACAGCCTCCATGATGTCTTTATTGCAAATATGGATGACAAGGGTCTCTGTTACAGGGGCCTCAGAGCACCTTCGTTTC
TCCTCTAGACCAGGGACAGGTGTAGAGATAAGGACTGGCAACCAGAGCCTCAGCATCCAAAGATGGACTGAAGTGGGATGGCTGACAGGC
ACATAACTTACGGGAAAGGGAATTTCATACATACGATTTTTGTTTTGTGGGTAGGAGGGCTTATCATCAACACTGATTTTATAATCTGAC
AATAAATGTCTTTCATTAAAGAGTTTACCTAAATGATGTTCGATTATATGTATAATTTATAAAATATTTATGTATAGTTTGTTTATTCAG
GTATATGTATAATTTATTGAACACCTACTATGTCCCAGCATATCTACAAAACTGGGTACATACATACTGTCTAACTGCTAATCCACATTT
CCAGTCTTACAAAGGACATAATGATTAGTTAAGCCCTAATTTAGATTTGAGGAAACTGAAGCTGAGAGAGGGTTAAGTAAATTACCCAAA
GTACAGCTAATAAGACCCAGAATCTCAGTCTCACTCCTTGGGATCCTGTGTATTTCCCTGAGTCTTCTAACATATGAAAATTCATATCTA
AATCAACAAGTGACTGTAATCTGGTACTATAAATACTAAATAAACACTTCTTCATAACACTGTACCAATTCAGCTTTTAAATTTTATTAC
TTTGCTTTCCTGTCCTTTGCCAACTCTTAACCTAGTTAATCCTAGTTCTGTTGACATTGGACCAGGCTCAGTAAATAAACGAATGGATTT
CCAGCCTTTTTTTCCCATCTGTTCCTGCTTTTAGTCCTCTGAATCTGCTTCTTTTCTTACTGCTGCTTTATTTTACAGTGATTTTGTCAA
ACATAGAATACAGGACTAAAAATGCAAAGAAATTGGGTCTGTGTTTAATTTTGATGTTTCAAATTTTGAGCTTCCAAGTCTTTGTGGCCA
CCCAATGAAGTTTGAGTCTGCCTGTTCAGATGTGAAAGGTAAGGGCTGCAGCAGGTTTAAGGGTGGCCCTTCACCACCCTGTTGTCACCT
GCACAGGCACTCCCCCATTTGCAGATGAAGAAATGTTCAGAGAAGAAAAATGATGGACCAAACGTCTGTTTGCACAATTGAAACTCTACC
AGTGGACTATTCTATTTTCACAGCTACCTAGTTTCTGCCGATGATTTTTTTAAATGTGAAATAAACAGTGATACTTTCAGGTTGAAGCTG
CCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGACATTAAAGAGATAGCCAAAAAGACACAAGCCCTGCCAAAGATGAACTCAAAGA
GGCAGCGAATCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACAGAAAGTGAAGTCACTGCTTTTGCTGTCTTGGATCAAG
ACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGATGCATTTGTTGGAGGTTTTCTGTCTCAACTGGTCTCTGACAAGCCTCTGACTG
AATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTTTCCTGAGAAGCCAGACTTCCACTGATGGA

>55014_55014_4_MRPL35-ADK_MRPL35_chr2_86437736_ENST00000337109_ADK_chr10_76349039_ENST00000541550_length(amino acids)=165AA_BP=
MSDYKISVDDKPSYPQNKNRMYEIPFPVSYVPVSHPTSVHLWMLRLWLPVLISTPVPGLEEKRRCSEAPVTETLVIHICNKDIMEAVQKY

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MRPL35-ADK

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MRPL35-ADK

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MRPL35-ADK

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source