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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MRPL42-POLR3B (FusionGDB2 ID:55047)

Fusion Gene Summary for MRPL42-POLR3B

check button Fusion gene summary
Fusion gene informationFusion gene name: MRPL42-POLR3B
Fusion gene ID: 55047
HgeneTgene
Gene symbol

MRPL42

POLR3B

Gene ID

28977

55703

Gene namemitochondrial ribosomal protein L42RNA polymerase III subunit B
SynonymsHSPC204|L31MT|L42MT|MRP-L31|MRP-L42|MRP-S32|MRPL31|MRPS32|PTD007|RPML31|S32MTC128|HLD8|INMAP|RPC2
Cytomap

12q22

12q23.3

Type of geneprotein-codingprotein-coding
Description39S ribosomal protein L42, mitochondrial28S ribosomal protein S32, mitochondrial39S ribosomal protein L31, mitochondrialmitochondrial large ribosomal subunit protein mL42DNA-directed RNA polymerase III subunit RPC2DNA-directed RNA polymerase III 127.6 kDa polypeptideDNA-directed RNA polymerase III subunit BRNA polymerase III subunit C2interphase nucleus and mitotic apparatus associated proteinpolymerase (RNA) III (DN
Modification date2020031320200313
UniProtAcc

Q9Y6G3

.
Ensembl transtripts involved in fusion geneENST00000361630, ENST00000393128, 
ENST00000547098, ENST00000548545, 
ENST00000549982, ENST00000552217, 
ENST00000552938, 		ENST00000549195, 
ENST00000539066, ENST00000228347, 
Fusion gene scores* DoF score8 X 6 X 5=2402 X 2 X 2=8
# samples 82
** MAII scorelog2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: MRPL42 [Title/Abstract] AND POLR3B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMRPL42(93881436)-POLR3B(106903198), # samples:2
Anticipated loss of major functional domain due to fusion event.MRPL42-POLR3B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MRPL42-POLR3B seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MRPL42-POLR3B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MRPL42 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across POLR3B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-CF-A7I0-01AMRPL42chr12

93881436

-POLR3Bchr12

106903198

+
ChimerDB4BLCATCGA-CF-A7I0-01AMRPL42chr12

93881436

+POLR3Bchr12

106903198

+


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Fusion Gene ORF analysis for MRPL42-POLR3B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000361630ENST00000549195MRPL42chr12

93881436

+POLR3Bchr12

106903198

+
5CDS-intronENST00000393128ENST00000549195MRPL42chr12

93881436

+POLR3Bchr12

106903198

+
5CDS-intronENST00000547098ENST00000549195MRPL42chr12

93881436

+POLR3Bchr12

106903198

+
5CDS-intronENST00000548545ENST00000549195MRPL42chr12

93881436

+POLR3Bchr12

106903198

+
5CDS-intronENST00000549982ENST00000549195MRPL42chr12

93881436

+POLR3Bchr12

106903198

+
5CDS-intronENST00000552217ENST00000549195MRPL42chr12

93881436

+POLR3Bchr12

106903198

+
Frame-shiftENST00000361630ENST00000539066MRPL42chr12

93881436

+POLR3Bchr12

106903198

+
Frame-shiftENST00000393128ENST00000539066MRPL42chr12

93881436

+POLR3Bchr12

106903198

+
Frame-shiftENST00000547098ENST00000539066MRPL42chr12

93881436

+POLR3Bchr12

106903198

+
Frame-shiftENST00000548545ENST00000539066MRPL42chr12

93881436

+POLR3Bchr12

106903198

+
Frame-shiftENST00000549982ENST00000539066MRPL42chr12

93881436

+POLR3Bchr12

106903198

+
Frame-shiftENST00000552217ENST00000539066MRPL42chr12

93881436

+POLR3Bchr12

106903198

+
In-frameENST00000361630ENST00000228347MRPL42chr12

93881436

+POLR3Bchr12

106903198

+
In-frameENST00000393128ENST00000228347MRPL42chr12

93881436

+POLR3Bchr12

106903198

+
In-frameENST00000547098ENST00000228347MRPL42chr12

93881436

+POLR3Bchr12

106903198

+
In-frameENST00000548545ENST00000228347MRPL42chr12

93881436

+POLR3Bchr12

106903198

+
In-frameENST00000549982ENST00000228347MRPL42chr12

93881436

+POLR3Bchr12

106903198

+
In-frameENST00000552217ENST00000228347MRPL42chr12

93881436

+POLR3Bchr12

106903198

+
intron-3CDSENST00000552938ENST00000228347MRPL42chr12

93881436

+POLR3Bchr12

106903198

+
intron-3CDSENST00000552938ENST00000539066MRPL42chr12

93881436

+POLR3Bchr12

106903198

+
intron-intronENST00000552938ENST00000549195MRPL42chr12

93881436

+POLR3Bchr12

106903198

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000549982MRPL42chr1293881436+ENST00000228347POLR3Bchr12106903198+1323544161673170
ENST00000361630MRPL42chr1293881436+ENST00000228347POLR3Bchr12106903198+134056173690205
ENST00000552217MRPL42chr1293881436+ENST00000228347POLR3Bchr12106903198+1298519136648170
ENST00000393128MRPL42chr1293881436+ENST00000228347POLR3Bchr12106903198+1294515132644170
ENST00000547098MRPL42chr1293881436+ENST00000228347POLR3Bchr12106903198+1296517134646170
ENST00000548545MRPL42chr1293881436+ENST00000228347POLR3Bchr12106903198+130752872389105

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000549982ENST00000228347MRPL42chr1293881436+POLR3Bchr12106903198+0.0058549010.9941451
ENST00000361630ENST00000228347MRPL42chr1293881436+POLR3Bchr12106903198+0.0039606360.9960394
ENST00000552217ENST00000228347MRPL42chr1293881436+POLR3Bchr12106903198+0.0062270460.9937729
ENST00000393128ENST00000228347MRPL42chr1293881436+POLR3Bchr12106903198+0.0060144790.9939856
ENST00000547098ENST00000228347MRPL42chr1293881436+POLR3Bchr12106903198+0.0061295630.9938704
ENST00000548545ENST00000228347MRPL42chr1293881436+POLR3Bchr12106903198+0.0687527360.93124723

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Fusion Genomic Features for MRPL42-POLR3B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MRPL42-POLR3B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:93881436/chr12:106903198)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MRPL42

Q9Y6G3

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePOLR3Bchr12:93881436chr12:106903198ENST0000053906626281080_109510321076.0Zinc fingerNote=C4-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePOLR3Bchr12:93881436chr12:106903198ENST0000022834726281080_109510901134.0Zinc fingerNote=C4-type


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Fusion Gene Sequence for MRPL42-POLR3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>55047_55047_1_MRPL42-POLR3B_MRPL42_chr12_93881436_ENST00000361630_POLR3B_chr12_106903198_ENST00000228347_length(transcript)=1340nt_BP=561nt
CGCTGTTTCGTGGGACCAGGATTGAAACAAGATGGCGGGTTCGTGGTGAGAAGCCGTCAAGCAGGAGTAGAAATTGGTATGCTTAGAAGC
AGATTCTAAAAGCAGTTTCTCTTCAGAACATCTTTTTTCATACCACTTGATAAGCATCTTGAAACACCATGGCTGTAGCTGCAGTAAAAT
GGGTGATGTCAAAGAGAACTATCTTGAAACATTTATTTCCAGTCCAAAATTCGGGCGTACATGTGCAGATGGAGCTTTATATTGTGTTTG
TCATAAATCTACGTATTCTCCTCTACCAGATGACTATAATTGCAACGTAGAGCTTGCTCTGACTTCTGATGGCAGGACAATAGTATGCTA
CCACCCTTCTGTGGACATTCCATATGAACACACAAAACCTATCCCTCGGCCAGATCCTGTGCATAATAATGAAGAAACACATGATCAAGT
GCTGAAAACCAGATTGGAAGAAAAAGTTGAACACCTTGAGGAAGGACCTATGATAGAACAACTTAGCAAAATGTTCTTTACTACTAAGCA
CCGTTGGTATCCTCATGGACGGTGCCATTACTGCAAGTCATCCTGCCACGTGTCTTCCCTCCGTATTCCGTATGCCTGCAAGCTGCTCTT
CCAGGAACTACAGTCTATGAACATCATCCCCAGGTTAAAACTGTCCAAGTACAATGAATGAGGATGGAAAAAATGATTATTAAAGAGAAC
AAGTGATACATCCAATGCAACGGAAAGCAGAAGGGATTTAGGACTACGTCTCCTCCTGTGAAGAATTCCCTTGCGTATTCTCTCTCTAAA
ACAACCAAAAAAAAATGGAGAGGCTTTTTATATACTCTAAGACTGGCTAAACAACCTTGATCATTGAGCCTCGAGCCATGGGAGAGATGC
TGACCATGTGGACTGCAAGGCTGCTTGATTCACAGATGGATGTGACCTAAAGGATAAATAAGCTATTACTTATGTGCTGATCTCTTGACA
TTCACTCATTAGAAGACCTTACTCCTTCAAGCAAATGTTTGGGGTCAAATTTACCATATCTTCTGGCTAACCATATTCAAGATTCTTCTG
AAACTTGGAGGATGTAAAGAATCCATTTGATTTGGTCAGCCTGGCTTTTGTCGTGGTGGCTGGCTCGGATAAATTTTCCCAACAATTAAA
TCTTGCCTTTACACACCCAAACTTTGTAATTTTAGTCTTGGTGAAATATAATGAATTTGTTCCTACCTTGTCAAGCAAGAATGTCGTCTT

>55047_55047_1_MRPL42-POLR3B_MRPL42_chr12_93881436_ENST00000361630_POLR3B_chr12_106903198_ENST00000228347_length(amino acids)=205AA_BP=162
MVCLEADSKSSFSSEHLFSYHLISILKHHGCSCSKMGDVKENYLETFISSPKFGRTCADGALYCVCHKSTYSPLPDDYNCNVELALTSDG
RTIVCYHPSVDIPYEHTKPIPRPDPVHNNEETHDQVLKTRLEEKVEHLEEGPMIEQLSKMFFTTKHRWYPHGRCHYCKSSCHVSSLRIPY

--------------------------------------------------------------
>55047_55047_2_MRPL42-POLR3B_MRPL42_chr12_93881436_ENST00000393128_POLR3B_chr12_106903198_ENST00000228347_length(transcript)=1294nt_BP=515nt
GAAACAAGATGGCGGGTTCGTGGTGAGAAGCCGTCAAGGAGTAGAAATTGGTATGCTTAGAAGCAGATTCTAAAAGCAGTTTCTCTTCAG
AACATCTTTTTTCATACCACTTGATAAGCATCTTGAAACACCATGGCTGTAGCTGCAGTAAAATGGGTGATGTCAAAGAGAACTATCTTG
AAACATTTATTTCCAGTCCAAAATGGAGCTTTATATTGTGTTTGTCATAAATCTACGTATTCTCCTCTACCAGATGACTATAATTGCAAC
GTAGAGCTTGCTCTGACTTCTGATGGCAGGACAATAGTATGCTACCACCCTTCTGTGGACATTCCATATGAACACACAAAACCTATCCCT
CGGCCAGATCCTGTGCATAATAATGAAGAAACACATGATCAAGTGCTGAAAACCAGATTGGAAGAAAAAGTTGAACACCTTGAGGAAGGA
CCTATGATAGAACAACTTAGCAAAATGTTCTTTACTACTAAGCACCGTTGGTATCCTCATGGACGGTGCCATTACTGCAAGTCATCCTGC
CACGTGTCTTCCCTCCGTATTCCGTATGCCTGCAAGCTGCTCTTCCAGGAACTACAGTCTATGAACATCATCCCCAGGTTAAAACTGTCC
AAGTACAATGAATGAGGATGGAAAAAATGATTATTAAAGAGAACAAGTGATACATCCAATGCAACGGAAAGCAGAAGGGATTTAGGACTA
CGTCTCCTCCTGTGAAGAATTCCCTTGCGTATTCTCTCTCTAAAACAACCAAAAAAAAATGGAGAGGCTTTTTATATACTCTAAGACTGG
CTAAACAACCTTGATCATTGAGCCTCGAGCCATGGGAGAGATGCTGACCATGTGGACTGCAAGGCTGCTTGATTCACAGATGGATGTGAC
CTAAAGGATAAATAAGCTATTACTTATGTGCTGATCTCTTGACATTCACTCATTAGAAGACCTTACTCCTTCAAGCAAATGTTTGGGGTC
AAATTTACCATATCTTCTGGCTAACCATATTCAAGATTCTTCTGAAACTTGGAGGATGTAAAGAATCCATTTGATTTGGTCAGCCTGGCT
TTTGTCGTGGTGGCTGGCTCGGATAAATTTTCCCAACAATTAAATCTTGCCTTTACACACCCAAACTTTGTAATTTTAGTCTTGGTGAAA
TATAATGAATTTGTTCCTACCTTGTCAAGCAAGAATGTCGTCTTCTCCTATGGACTCAATTGCTATTATTTTAAACCTGCATGATTGTAC

>55047_55047_2_MRPL42-POLR3B_MRPL42_chr12_93881436_ENST00000393128_POLR3B_chr12_106903198_ENST00000228347_length(amino acids)=170AA_BP=127
MAVAAVKWVMSKRTILKHLFPVQNGALYCVCHKSTYSPLPDDYNCNVELALTSDGRTIVCYHPSVDIPYEHTKPIPRPDPVHNNEETHDQ

--------------------------------------------------------------
>55047_55047_3_MRPL42-POLR3B_MRPL42_chr12_93881436_ENST00000547098_POLR3B_chr12_106903198_ENST00000228347_length(transcript)=1296nt_BP=517nt
AAACAAGATGGCGGGTTCGTGGTGAGAAGCCGTCAAGCAGGAGTAGAAATTGGTATGCTTAGAAGCAGATTCTAAAAGCAGTTTCTCTTC
AGAACATCTTTTTTCATACCACTTGATAAGCATCTTGAAACACCATGGCTGTAGCTGCAGTAAAATGGGTGATGTCAAAGAGAACTATCT
TGAAACATTTATTTCCAGTCCAAAATGGAGCTTTATATTGTGTTTGTCATAAATCTACGTATTCTCCTCTACCAGATGACTATAATTGCA
ACGTAGAGCTTGCTCTGACTTCTGATGGCAGGACAATAGTATGCTACCACCCTTCTGTGGACATTCCATATGAACACACAAAACCTATCC
CTCGGCCAGATCCTGTGCATAATAATGAAGAAACACATGATCAAGTGCTGAAAACCAGATTGGAAGAAAAAGTTGAACACCTTGAGGAAG
GACCTATGATAGAACAACTTAGCAAAATGTTCTTTACTACTAAGCACCGTTGGTATCCTCATGGACGGTGCCATTACTGCAAGTCATCCT
GCCACGTGTCTTCCCTCCGTATTCCGTATGCCTGCAAGCTGCTCTTCCAGGAACTACAGTCTATGAACATCATCCCCAGGTTAAAACTGT
CCAAGTACAATGAATGAGGATGGAAAAAATGATTATTAAAGAGAACAAGTGATACATCCAATGCAACGGAAAGCAGAAGGGATTTAGGAC
TACGTCTCCTCCTGTGAAGAATTCCCTTGCGTATTCTCTCTCTAAAACAACCAAAAAAAAATGGAGAGGCTTTTTATATACTCTAAGACT
GGCTAAACAACCTTGATCATTGAGCCTCGAGCCATGGGAGAGATGCTGACCATGTGGACTGCAAGGCTGCTTGATTCACAGATGGATGTG
ACCTAAAGGATAAATAAGCTATTACTTATGTGCTGATCTCTTGACATTCACTCATTAGAAGACCTTACTCCTTCAAGCAAATGTTTGGGG
TCAAATTTACCATATCTTCTGGCTAACCATATTCAAGATTCTTCTGAAACTTGGAGGATGTAAAGAATCCATTTGATTTGGTCAGCCTGG
CTTTTGTCGTGGTGGCTGGCTCGGATAAATTTTCCCAACAATTAAATCTTGCCTTTACACACCCAAACTTTGTAATTTTAGTCTTGGTGA
AATATAATGAATTTGTTCCTACCTTGTCAAGCAAGAATGTCGTCTTCTCCTATGGACTCAATTGCTATTATTTTAAACCTGCATGATTGT

>55047_55047_3_MRPL42-POLR3B_MRPL42_chr12_93881436_ENST00000547098_POLR3B_chr12_106903198_ENST00000228347_length(amino acids)=170AA_BP=127
MAVAAVKWVMSKRTILKHLFPVQNGALYCVCHKSTYSPLPDDYNCNVELALTSDGRTIVCYHPSVDIPYEHTKPIPRPDPVHNNEETHDQ

--------------------------------------------------------------
>55047_55047_4_MRPL42-POLR3B_MRPL42_chr12_93881436_ENST00000548545_POLR3B_chr12_106903198_ENST00000228347_length(transcript)=1307nt_BP=528nt
AAGCAGATTCTAAAAGCAGTTTCTCTTCAGAACATCTTTTTTCATACCACTTGATAAGCATCTTGAAACACCATGGCTGTAGCTGCAGTA
AAATGGGTGATGTCAAAGAGAACTATCTTGAAACATTTATTTCCAGTCCAAAATGGAGCTTTATATTGTGTTTGTCATAAATCTACGTAT
TCTCCTCTACCAGATGACTATAATTGCAACGTAGAGCTTGCTCTGACTTCTGATGGCAGGACAATAGTATGCTACCACCCTTCTGTGGAC
ATTCCATATGAACACACAAAAGTAAGTTTTCTTTTCTTTTCTTCAATCCCTACTACATACAGTAAAGGAACACATGGATTTTCTTGCAAT
AACAAACTTCTGAAGTGGTGTTTTGCATGAGGAAATTAACCCTAAGTAGAATCACCTACTATGTTGTACTTTTTTTTTCTTTTCTGAGAC
AGGATCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGCCACAATCTCAGCTCACTGCAGCCTCAACCTCCAGTGCTCAAGTGCCATTACTG
CAAGTCATCCTGCCACGTGTCTTCCCTCCGTATTCCGTATGCCTGCAAGCTGCTCTTCCAGGAACTACAGTCTATGAACATCATCCCCAG
GTTAAAACTGTCCAAGTACAATGAATGAGGATGGAAAAAATGATTATTAAAGAGAACAAGTGATACATCCAATGCAACGGAAAGCAGAAG
GGATTTAGGACTACGTCTCCTCCTGTGAAGAATTCCCTTGCGTATTCTCTCTCTAAAACAACCAAAAAAAAATGGAGAGGCTTTTTATAT
ACTCTAAGACTGGCTAAACAACCTTGATCATTGAGCCTCGAGCCATGGGAGAGATGCTGACCATGTGGACTGCAAGGCTGCTTGATTCAC
AGATGGATGTGACCTAAAGGATAAATAAGCTATTACTTATGTGCTGATCTCTTGACATTCACTCATTAGAAGACCTTACTCCTTCAAGCA
AATGTTTGGGGTCAAATTTACCATATCTTCTGGCTAACCATATTCAAGATTCTTCTGAAACTTGGAGGATGTAAAGAATCCATTTGATTT
GGTCAGCCTGGCTTTTGTCGTGGTGGCTGGCTCGGATAAATTTTCCCAACAATTAAATCTTGCCTTTACACACCCAAACTTTGTAATTTT
AGTCTTGGTGAAATATAATGAATTTGTTCCTACCTTGTCAAGCAAGAATGTCGTCTTCTCCTATGGACTCAATTGCTATTATTTTAAACC

>55047_55047_4_MRPL42-POLR3B_MRPL42_chr12_93881436_ENST00000548545_POLR3B_chr12_106903198_ENST00000228347_length(amino acids)=105AA_BP=
MAVAAVKWVMSKRTILKHLFPVQNGALYCVCHKSTYSPLPDDYNCNVELALTSDGRTIVCYHPSVDIPYEHTKVSFLFFSSIPTTYSKGT

--------------------------------------------------------------
>55047_55047_5_MRPL42-POLR3B_MRPL42_chr12_93881436_ENST00000549982_POLR3B_chr12_106903198_ENST00000228347_length(transcript)=1323nt_BP=544nt
GCGCAGCGCTGTTTCGTGGGACCAGGATTGAAACAAGATGGCGGGTTCGTGGTGAGAAGCCGTCAAGGAGTAGAAATTGGTATGCTTAGA
AGCAGATTCTAAAAGCAGTTTCTCTTCAGAACATCTTTTTTCATACCACTTGATAAGCATCTTGAAACACCATGGCTGTAGCTGCAGTAA
AATGGGTGATGTCAAAGAGAACTATCTTGAAACATTTATTTCCAGTCCAAAATGGAGCTTTATATTGTGTTTGTCATAAATCTACGTATT
CTCCTCTACCAGATGACTATAATTGCAACGTAGAGCTTGCTCTGACTTCTGATGGCAGGACAATAGTATGCTACCACCCTTCTGTGGACA
TTCCATATGAACACACAAAACCTATCCCTCGGCCAGATCCTGTGCATAATAATGAAGAAACACATGATCAAGTGCTGAAAACCAGATTGG
AAGAAAAAGTTGAACACCTTGAGGAAGGACCTATGATAGAACAACTTAGCAAAATGTTCTTTACTACTAAGCACCGTTGGTATCCTCATG
GACGGTGCCATTACTGCAAGTCATCCTGCCACGTGTCTTCCCTCCGTATTCCGTATGCCTGCAAGCTGCTCTTCCAGGAACTACAGTCTA
TGAACATCATCCCCAGGTTAAAACTGTCCAAGTACAATGAATGAGGATGGAAAAAATGATTATTAAAGAGAACAAGTGATACATCCAATG
CAACGGAAAGCAGAAGGGATTTAGGACTACGTCTCCTCCTGTGAAGAATTCCCTTGCGTATTCTCTCTCTAAAACAACCAAAAAAAAATG
GAGAGGCTTTTTATATACTCTAAGACTGGCTAAACAACCTTGATCATTGAGCCTCGAGCCATGGGAGAGATGCTGACCATGTGGACTGCA
AGGCTGCTTGATTCACAGATGGATGTGACCTAAAGGATAAATAAGCTATTACTTATGTGCTGATCTCTTGACATTCACTCATTAGAAGAC
CTTACTCCTTCAAGCAAATGTTTGGGGTCAAATTTACCATATCTTCTGGCTAACCATATTCAAGATTCTTCTGAAACTTGGAGGATGTAA
AGAATCCATTTGATTTGGTCAGCCTGGCTTTTGTCGTGGTGGCTGGCTCGGATAAATTTTCCCAACAATTAAATCTTGCCTTTACACACC
CAAACTTTGTAATTTTAGTCTTGGTGAAATATAATGAATTTGTTCCTACCTTGTCAAGCAAGAATGTCGTCTTCTCCTATGGACTCAATT

>55047_55047_5_MRPL42-POLR3B_MRPL42_chr12_93881436_ENST00000549982_POLR3B_chr12_106903198_ENST00000228347_length(amino acids)=170AA_BP=127
MAVAAVKWVMSKRTILKHLFPVQNGALYCVCHKSTYSPLPDDYNCNVELALTSDGRTIVCYHPSVDIPYEHTKPIPRPDPVHNNEETHDQ

--------------------------------------------------------------
>55047_55047_6_MRPL42-POLR3B_MRPL42_chr12_93881436_ENST00000552217_POLR3B_chr12_106903198_ENST00000228347_length(transcript)=1298nt_BP=519nt
TGAAACAAGATGGCGGGTTCGTGGTGAGAAGCCGTCAAGCAGGAGTAGAAATTGGTATGCTTAGAAGCAGATTCTAAAAGCAGTTTCTCT
TCAGAACATCTTTTTTCATACCACTTGATAAGCATCTTGAAACACCATGGCTGTAGCTGCAGTAAAATGGGTGATGTCAAAGAGAACTAT
CTTGAAACATTTATTTCCAGTCCAAAATGGAGCTTTATATTGTGTTTGTCATAAATCTACGTATTCTCCTCTACCAGATGACTATAATTG
CAACGTAGAGCTTGCTCTGACTTCTGATGGCAGGACAATAGTATGCTACCACCCTTCTGTGGACATTCCATATGAACACACAAAACCTAT
CCCTCGGCCAGATCCTGTGCATAATAATGAAGAAACACATGATCAAGTGCTGAAAACCAGATTGGAAGAAAAAGTTGAACACCTTGAGGA
AGGACCTATGATAGAACAACTTAGCAAAATGTTCTTTACTACTAAGCACCGTTGGTATCCTCATGGACGGTGCCATTACTGCAAGTCATC
CTGCCACGTGTCTTCCCTCCGTATTCCGTATGCCTGCAAGCTGCTCTTCCAGGAACTACAGTCTATGAACATCATCCCCAGGTTAAAACT
GTCCAAGTACAATGAATGAGGATGGAAAAAATGATTATTAAAGAGAACAAGTGATACATCCAATGCAACGGAAAGCAGAAGGGATTTAGG
ACTACGTCTCCTCCTGTGAAGAATTCCCTTGCGTATTCTCTCTCTAAAACAACCAAAAAAAAATGGAGAGGCTTTTTATATACTCTAAGA
CTGGCTAAACAACCTTGATCATTGAGCCTCGAGCCATGGGAGAGATGCTGACCATGTGGACTGCAAGGCTGCTTGATTCACAGATGGATG
TGACCTAAAGGATAAATAAGCTATTACTTATGTGCTGATCTCTTGACATTCACTCATTAGAAGACCTTACTCCTTCAAGCAAATGTTTGG
GGTCAAATTTACCATATCTTCTGGCTAACCATATTCAAGATTCTTCTGAAACTTGGAGGATGTAAAGAATCCATTTGATTTGGTCAGCCT
GGCTTTTGTCGTGGTGGCTGGCTCGGATAAATTTTCCCAACAATTAAATCTTGCCTTTACACACCCAAACTTTGTAATTTTAGTCTTGGT
GAAATATAATGAATTTGTTCCTACCTTGTCAAGCAAGAATGTCGTCTTCTCCTATGGACTCAATTGCTATTATTTTAAACCTGCATGATT

>55047_55047_6_MRPL42-POLR3B_MRPL42_chr12_93881436_ENST00000552217_POLR3B_chr12_106903198_ENST00000228347_length(amino acids)=170AA_BP=127
MAVAAVKWVMSKRTILKHLFPVQNGALYCVCHKSTYSPLPDDYNCNVELALTSDGRTIVCYHPSVDIPYEHTKPIPRPDPVHNNEETHDQ

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Fusion Gene PPI Analysis for MRPL42-POLR3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MRPL42-POLR3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MRPL42-POLR3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource