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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MRPL4-TRIM26 (FusionGDB2 ID:55088)

Fusion Gene Summary for MRPL4-TRIM26

check button Fusion gene summary
Fusion gene informationFusion gene name: MRPL4-TRIM26
Fusion gene ID: 55088
HgeneTgene
Gene symbol

MRPL4

TRIM26

Gene ID

51073

7726

Gene namemitochondrial ribosomal protein L4tripartite motif containing 26
SynonymsCGI-28|L4mtAFP|RNF95|ZNF173
Cytomap

19p13.2

6p22.1

Type of geneprotein-codingprotein-coding
Description39S ribosomal protein L4, mitochondrialMRP-L4mitochondrial large ribosomal subunit protein uL4mtripartite motif-containing protein 26RING finger protein 95acid finger proteinwidely expressed acid zinc finger proteinzinc finger protein 173
Modification date2020031320200313
UniProtAcc

Q9BYD3

.
Ensembl transtripts involved in fusion geneENST00000393733, ENST00000253099, 
ENST00000307422, ENST00000588502, 
ENST00000590669, 		ENST00000437089, 
ENST00000453195, ENST00000454678, 
ENST00000327357, ENST00000383607, 
ENST00000396558, ENST00000415923, 
ENST00000422349, ENST00000425523, 
ENST00000425831, ENST00000427535, 
ENST00000428486, ENST00000432326, 
ENST00000433314, ENST00000436219, 
ENST00000438384, ENST00000438908, 
ENST00000439094, ENST00000445259, 
ENST00000447711, ENST00000450392, 
ENST00000455000, ENST00000456093, 
ENST00000456770, ENST00000463977, 
ENST00000475230, ENST00000477353, 
ENST00000477569, ENST00000481596, 
ENST00000484938, ENST00000486529, 
ENST00000487829, 
Fusion gene scores* DoF score6 X 7 X 2=845 X 5 X 5=125
# samples 78
** MAII scorelog2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/125*10)=-0.643856189774725
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MRPL4 [Title/Abstract] AND TRIM26 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMRPL4(10370369)-TRIM26(30154297), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTRIM26

GO:0045087

innate immune response

18248090

TgeneTRIM26

GO:0046597

negative regulation of viral entry into host cell

18248090

TgeneTRIM26

GO:0051091

positive regulation of DNA-binding transcription factor activity

23077300

TgeneTRIM26

GO:1902187

negative regulation of viral release from host cell

18248090


check buttonFusion gene breakpoints across MRPL4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TRIM26 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-5721-01AMRPL4chr19

10370369

+TRIM26chr6

30154297

-


Top

Fusion Gene ORF analysis for MRPL4-TRIM26

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000393733ENST00000437089MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-3CDSENST00000393733ENST00000453195MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-3CDSENST00000393733ENST00000454678MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000327357MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000383607MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000396558MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000415923MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000422349MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000425523MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000425831MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000427535MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000428486MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000432326MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000433314MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000436219MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000438384MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000438908MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000439094MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000445259MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000447711MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000450392MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000455000MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000456093MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000456770MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000463977MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000475230MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000477353MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000477569MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000481596MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000484938MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000486529MRPL4chr19

10370369

+TRIM26chr6

30154297

-
3UTR-intronENST00000393733ENST00000487829MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000327357MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000383607MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000396558MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000415923MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000422349MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000425523MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000425831MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000427535MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000428486MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000432326MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000433314MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000436219MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000438384MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000438908MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000439094MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000445259MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000447711MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000450392MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000455000MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000456093MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000456770MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000463977MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000475230MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000477353MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000477569MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000481596MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000484938MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000486529MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000253099ENST00000487829MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000327357MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000383607MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000396558MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000415923MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000422349MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000425523MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000425831MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000427535MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000428486MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000432326MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000433314MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000436219MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000438384MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000438908MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000439094MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000445259MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000447711MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000450392MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000455000MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000456093MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000456770MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000463977MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000475230MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000477353MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000477569MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000481596MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000484938MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000486529MRPL4chr19

10370369

+TRIM26chr6

30154297

-
5CDS-intronENST00000307422ENST00000487829MRPL4chr19

10370369

+TRIM26chr6

30154297

-
Frame-shiftENST00000253099ENST00000453195MRPL4chr19

10370369

+TRIM26chr6

30154297

-
Frame-shiftENST00000307422ENST00000437089MRPL4chr19

10370369

+TRIM26chr6

30154297

-
Frame-shiftENST00000307422ENST00000453195MRPL4chr19

10370369

+TRIM26chr6

30154297

-
Frame-shiftENST00000307422ENST00000454678MRPL4chr19

10370369

+TRIM26chr6

30154297

-
In-frameENST00000253099ENST00000437089MRPL4chr19

10370369

+TRIM26chr6

30154297

-
In-frameENST00000253099ENST00000454678MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-3CDSENST00000588502ENST00000437089MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-3CDSENST00000588502ENST00000453195MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-3CDSENST00000588502ENST00000454678MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-3CDSENST00000590669ENST00000437089MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-3CDSENST00000590669ENST00000453195MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-3CDSENST00000590669ENST00000454678MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000327357MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000383607MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000396558MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000415923MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000422349MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000425523MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000425831MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000427535MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000428486MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000432326MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000433314MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000436219MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000438384MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000438908MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000439094MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000445259MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000447711MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000450392MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000455000MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000456093MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000456770MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000463977MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000475230MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000477353MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000477569MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000481596MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000484938MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000486529MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000588502ENST00000487829MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000327357MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000383607MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000396558MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000415923MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000422349MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000425523MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000425831MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000427535MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000428486MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000432326MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000433314MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000436219MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000438384MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000438908MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000439094MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000445259MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000447711MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000450392MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000455000MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000456093MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000456770MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000463977MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000475230MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000477353MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000477569MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000481596MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000484938MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000486529MRPL4chr19

10370369

+TRIM26chr6

30154297

-
intron-intronENST00000590669ENST00000487829MRPL4chr19

10370369

+TRIM26chr6

30154297

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000253099MRPL4chr1910370369+ENST00000437089TRIM26chr630154297-344413782541150298
ENST00000253099MRPL4chr1910370369+ENST00000454678TRIM26chr630154297-344413782541150298

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000253099ENST00000437089MRPL4chr1910370369+TRIM26chr630154297-0.080018980.91998106
ENST00000253099ENST00000454678MRPL4chr1910370369+TRIM26chr630154297-0.080018980.91998106

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Fusion Genomic Features for MRPL4-TRIM26


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MRPL4-TRIM26


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:10370369/chr6:30154297)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MRPL4

Q9BYD3

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTRIM26chr19:10370369chr6:30154297ENST00000327357010188_2270540.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM26chr19:10370369chr6:30154297ENST0000038360709188_2270540.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM26chr19:10370369chr6:30154297ENST0000039655809188_2270540.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM26chr19:10370369chr6:30154297ENST00000415923010188_2270540.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM26chr19:10370369chr6:30154297ENST0000042234909188_2270540.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM26chr19:10370369chr6:30154297ENST0000042552309188_2270540.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM26chr19:10370369chr6:30154297ENST0000042583109188_2270540.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM26chr19:10370369chr6:30154297ENST0000042753509188_2270540.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM26chr19:10370369chr6:30154297ENST0000042848609188_2270540.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM26chr19:10370369chr6:30154297ENST00000432326010188_2270540.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM26chr19:10370369chr6:30154297ENST0000043331409188_2270540.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM26chr19:10370369chr6:30154297ENST0000043621909188_2270540.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM26chr19:10370369chr6:30154297ENST0000043708909188_2270540.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM26chr19:10370369chr6:30154297ENST0000043838409188_2270540.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM26chr19:10370369chr6:30154297ENST0000043890809188_2270540.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM26chr19:10370369chr6:30154297ENST00000439094010188_2270540.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM26chr19:10370369chr6:30154297ENST00000445259010188_2270540.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM26chr19:10370369chr6:30154297ENST00000447711010188_2270540.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM26chr19:10370369chr6:30154297ENST0000045039209188_2270540.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM26chr19:10370369chr6:30154297ENST0000045319509188_2270540.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM26chr19:10370369chr6:30154297ENST00000454678010188_2270540.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM26chr19:10370369chr6:30154297ENST00000455000010188_2270540.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM26chr19:10370369chr6:30154297ENST0000045609309188_2270540.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM26chr19:10370369chr6:30154297ENST0000045677009188_2270540.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM26chr19:10370369chr6:30154297ENST00000327357010388_4000540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST00000327357010422_4320540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000038360709388_4000540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000038360709422_4320540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000039655809388_4000540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000039655809422_4320540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST00000415923010388_4000540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST00000415923010422_4320540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000042234909388_4000540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000042234909422_4320540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000042552309388_4000540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000042552309422_4320540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000042583109388_4000540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000042583109422_4320540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000042753509388_4000540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000042753509422_4320540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000042848609388_4000540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000042848609422_4320540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST00000432326010388_4000540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST00000432326010422_4320540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000043331409388_4000540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000043331409422_4320540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000043621909388_4000540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000043621909422_4320540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000043708909388_4000540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000043708909422_4320540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000043838409388_4000540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000043838409422_4320540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000043890809388_4000540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000043890809422_4320540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST00000439094010388_4000540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST00000439094010422_4320540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST00000445259010388_4000540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST00000445259010422_4320540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST00000447711010388_4000540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST00000447711010422_4320540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000045039209388_4000540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000045039209422_4320540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000045319509388_4000540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000045319509422_4320540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST00000454678010388_4000540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST00000454678010422_4320540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST00000455000010388_4000540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST00000455000010422_4320540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000045609309388_4000540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000045609309422_4320540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000045677009388_4000540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST0000045677009422_4320540.0Compositional biasNote=Poly-Glu
TgeneTRIM26chr19:10370369chr6:30154297ENST00000327357010295_5390540.0DomainB30.2/SPRY
TgeneTRIM26chr19:10370369chr6:30154297ENST0000038360709295_5390540.0DomainB30.2/SPRY
TgeneTRIM26chr19:10370369chr6:30154297ENST0000039655809295_5390540.0DomainB30.2/SPRY
TgeneTRIM26chr19:10370369chr6:30154297ENST00000415923010295_5390540.0DomainB30.2/SPRY
TgeneTRIM26chr19:10370369chr6:30154297ENST0000042234909295_5390540.0DomainB30.2/SPRY
TgeneTRIM26chr19:10370369chr6:30154297ENST0000042552309295_5390540.0DomainB30.2/SPRY
TgeneTRIM26chr19:10370369chr6:30154297ENST0000042583109295_5390540.0DomainB30.2/SPRY
TgeneTRIM26chr19:10370369chr6:30154297ENST0000042753509295_5390540.0DomainB30.2/SPRY
TgeneTRIM26chr19:10370369chr6:30154297ENST0000042848609295_5390540.0DomainB30.2/SPRY
TgeneTRIM26chr19:10370369chr6:30154297ENST00000432326010295_5390540.0DomainB30.2/SPRY
TgeneTRIM26chr19:10370369chr6:30154297ENST0000043331409295_5390540.0DomainB30.2/SPRY
TgeneTRIM26chr19:10370369chr6:30154297ENST0000043621909295_5390540.0DomainB30.2/SPRY
TgeneTRIM26chr19:10370369chr6:30154297ENST0000043708909295_5390540.0DomainB30.2/SPRY
TgeneTRIM26chr19:10370369chr6:30154297ENST0000043838409295_5390540.0DomainB30.2/SPRY
TgeneTRIM26chr19:10370369chr6:30154297ENST0000043890809295_5390540.0DomainB30.2/SPRY
TgeneTRIM26chr19:10370369chr6:30154297ENST00000439094010295_5390540.0DomainB30.2/SPRY
TgeneTRIM26chr19:10370369chr6:30154297ENST00000445259010295_5390540.0DomainB30.2/SPRY
TgeneTRIM26chr19:10370369chr6:30154297ENST00000447711010295_5390540.0DomainB30.2/SPRY
TgeneTRIM26chr19:10370369chr6:30154297ENST0000045039209295_5390540.0DomainB30.2/SPRY
TgeneTRIM26chr19:10370369chr6:30154297ENST0000045319509295_5390540.0DomainB30.2/SPRY
TgeneTRIM26chr19:10370369chr6:30154297ENST00000454678010295_5390540.0DomainB30.2/SPRY
TgeneTRIM26chr19:10370369chr6:30154297ENST00000455000010295_5390540.0DomainB30.2/SPRY
TgeneTRIM26chr19:10370369chr6:30154297ENST0000045609309295_5390540.0DomainB30.2/SPRY
TgeneTRIM26chr19:10370369chr6:30154297ENST0000045677009295_5390540.0DomainB30.2/SPRY
TgeneTRIM26chr19:10370369chr6:30154297ENST0000032735701016_570540.0Zinc fingerRING-type
TgeneTRIM26chr19:10370369chr6:30154297ENST0000032735701097_1380540.0Zinc fingerB box-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000003836070916_570540.0Zinc fingerRING-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000003836070997_1380540.0Zinc fingerB box-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000003965580916_570540.0Zinc fingerRING-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000003965580997_1380540.0Zinc fingerB box-type
TgeneTRIM26chr19:10370369chr6:30154297ENST0000041592301016_570540.0Zinc fingerRING-type
TgeneTRIM26chr19:10370369chr6:30154297ENST0000041592301097_1380540.0Zinc fingerB box-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004223490916_570540.0Zinc fingerRING-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004223490997_1380540.0Zinc fingerB box-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004255230916_570540.0Zinc fingerRING-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004255230997_1380540.0Zinc fingerB box-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004258310916_570540.0Zinc fingerRING-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004258310997_1380540.0Zinc fingerB box-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004275350916_570540.0Zinc fingerRING-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004275350997_1380540.0Zinc fingerB box-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004284860916_570540.0Zinc fingerRING-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004284860997_1380540.0Zinc fingerB box-type
TgeneTRIM26chr19:10370369chr6:30154297ENST0000043232601016_570540.0Zinc fingerRING-type
TgeneTRIM26chr19:10370369chr6:30154297ENST0000043232601097_1380540.0Zinc fingerB box-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004333140916_570540.0Zinc fingerRING-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004333140997_1380540.0Zinc fingerB box-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004362190916_570540.0Zinc fingerRING-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004362190997_1380540.0Zinc fingerB box-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004370890916_570540.0Zinc fingerRING-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004370890997_1380540.0Zinc fingerB box-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004383840916_570540.0Zinc fingerRING-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004383840997_1380540.0Zinc fingerB box-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004389080916_570540.0Zinc fingerRING-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004389080997_1380540.0Zinc fingerB box-type
TgeneTRIM26chr19:10370369chr6:30154297ENST0000043909401016_570540.0Zinc fingerRING-type
TgeneTRIM26chr19:10370369chr6:30154297ENST0000043909401097_1380540.0Zinc fingerB box-type
TgeneTRIM26chr19:10370369chr6:30154297ENST0000044525901016_570540.0Zinc fingerRING-type
TgeneTRIM26chr19:10370369chr6:30154297ENST0000044525901097_1380540.0Zinc fingerB box-type
TgeneTRIM26chr19:10370369chr6:30154297ENST0000044771101016_570540.0Zinc fingerRING-type
TgeneTRIM26chr19:10370369chr6:30154297ENST0000044771101097_1380540.0Zinc fingerB box-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004503920916_570540.0Zinc fingerRING-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004503920997_1380540.0Zinc fingerB box-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004531950916_570540.0Zinc fingerRING-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004531950997_1380540.0Zinc fingerB box-type
TgeneTRIM26chr19:10370369chr6:30154297ENST0000045467801016_570540.0Zinc fingerRING-type
TgeneTRIM26chr19:10370369chr6:30154297ENST0000045467801097_1380540.0Zinc fingerB box-type
TgeneTRIM26chr19:10370369chr6:30154297ENST0000045500001016_570540.0Zinc fingerRING-type
TgeneTRIM26chr19:10370369chr6:30154297ENST0000045500001097_1380540.0Zinc fingerB box-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004560930916_570540.0Zinc fingerRING-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004560930997_1380540.0Zinc fingerB box-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004567700916_570540.0Zinc fingerRING-type
TgeneTRIM26chr19:10370369chr6:30154297ENST000004567700997_1380540.0Zinc fingerB box-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MRPL4-TRIM26


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>55088_55088_1_MRPL4-TRIM26_MRPL4_chr19_10370369_ENST00000253099_TRIM26_chr6_30154297_ENST00000437089_length(transcript)=3444nt_BP=1378nt
AAAGTAGGCTAGGCCTACGGAAGCTGGGTCTTCTTGCTGTGAGGTCGCGTTCCCCAGTGTTACGGAGGGTCCTTGAGGCAGGAGTGAAAA
TTGGGTCTGGGGGTTAGTCCTGGGGTGGAGGTCTGGGCACGCCGGGTCGGACCCCCTCCATCTTCGGTTTTGCACACCCCGCTTTCCAGC
GCGGAGTCGCGGCGGGTAGGGCGGCGTCGCGTGCGTGACGTCATCCAGCGGCGCCTCGCGAGGCTCCAGTGGCCTTGACCTCCCGCGGCG
TGGGAGGCTGCGCGGCGATGCTGCAGTTCGTCCGGGCCGGGGCGCGGGCCTGGCTTCGGCCTACCGGCAGCCAGGGCCTGAGTTCCCTGG
CGGAAGAGGCAGCGCGTGCGACCGAGAACCCGGAGCAGGTGGCGAGCGAGGGTCTCCCGGAGCCCGTGCTGCGCAAAGTCGAGCTCCCGG
TACCCACTCATCGACGCCCAGTGCAGGCCTGGGTCGAGTCCTTGCGGGGCTTCGAGCAGGAGCGCGTGGGCCTGGCCGACCTGCACCCCG
ATGTTTTCGCCACCGCGCCCAGGCTGGACATACTGCACCAGGTTGCTATGTGGCAGAAGAACTTCAAGAGAATTAGCTATGCCAAGACCA
AGACGAGAGCCGAGGTGCGGGGCGGTGGCCGGAAGCCTTGGCCGCAGAAAGGCACTGGGCGGGCCCGGCATGGCAGCATCCGCTCTCCGC
TCTGGCGAGGAGGAGGTGTTGCCCATGGCCCCCGGGGCCCCACAAGTTACTACTACATGCTGCCCATGAAGGTGCGGGCGCTGGGTCTCA
AAGTGGCACTGACCGTCAAGCTGGCCCAGGACGACCTGCACATCATGGACTCCCTAGAGCTGCCCACCGGAGACCCACAGTACCTGACAG
AGCTGGCGCACTACCGCCGCTGGGGGGACTCCGTACTCCTCGTGGACTTAACACACGAGGAGATGCCACAGAGCATCGTGGAGGCCACCT
CTAGGCTTAAGACCTTCAACTTGATCCCGGCTGTTGCTGCTCTGGCAGGACTCACGTTACAGACCCCTCTACCCCTTCAGCCTGCCCTAC
AGCGACTTCCCCCGACCCCTACCCCACGCTACCCAGGGCCCAGCGGCCACCCCGTACCACTGTTGATGTGAAGCACCTCTTCTGAGCCAG
GCCGAGCCCCTGGCCGACTTGGGAGCCTCAGGCCCACGCCCACCCTTCGAGGAAGGTGTCACCTGGACCCCTTCATTCCACGGAGGAAGC
TGAGGCCACAGGGAGCGGCCATCGCCATTGGGAAGGGGCGACTCCACGGAAAGCCCAGACGGGCTTCTGCATCCATTCCCTCTTTTTGTT
TTTAAAATAAATTGTATTTTTGAATCAACTGCAGCTGTCAGAGGACTGGAAGTGCGTGACCTACACCAGCCTGTACAAGAGTGCCTACCT
GCACCCCCAGCAGTTTGACTGTGAGCCTGGGGTGCTAGGCAGCAAGGGCTTCACCTGGGGCAAGGTCTACTGGGAAGTGGAAGTGGAGAG
GGAGGGCTGGTCTGAGGATGAAGAAGAGGGGGATGAGGAGGAAGAGGGAGAAGAGGAGGAGGAGGAAGAGGAGGCCGGCTATGGGGATGG
ATATGACGACTGGGAAACGGACGAAGATGAGGAATCGTTGGGCGATGAAGAGGAAGAAGAGGAGGAGGAAGAGGAGGAAGTTCTGGAAAG
CTGCATGGTGGGGGTGGCTAGAGACTCTGTGAAGAGGAAGGGAGACCTCTCCCTGCGGCCAGAGGATGGCGTGTGGGCGCTGCGCCTCTC
CTCCTCCGGCATCTGGGCCAACACCAGCCCCGAGGCTGAGCTTTTCCCAGCACTGCGGCCCCGGAGAGTGGGCATCGCCCTGGATTATGA
AGGGGGCACCGTGACTTTCACCAACGCAGAGTCACAGGAACTCATCTACACCTTCACTGCCACCTTCACCCGGCGCCTGGTCCCCTTCCT
GTGGCTCAAGTGGCCAGGAACACGCCTCCTGCTAAGACCCTGAGCCCTGACATCTGCCCCCAGCCCCAACCCTCAGATGCTTCACTTCTT
TGGAATTCCAGGACTCTCAATGGGGGGACGGGATGCCTGGCCTAAGCACCTGGAGCAGGGGACCCCATATCCACTGGTAGCCACCTCCCC
ATTGCTGTGGCCCCCTGAAATCTCACTCAGTGCTGTTGCTCCATCTACTGCCCTAATGGGGCTCTTTTCCCACCTCCTGCTGGTTTCCCG
AGGGAACTTCTGACCCTGGAGTCCATGAGGGCTCCTTTCCTTTTTGACCACGACCTTGGCCCCAGCTCTGCACTCTCTGGAATAAGGGCC
CGATGCAGCATTTTCTTGCCCAGTGTGGCAAGACCTCAGAAAAACCAGTCAATTACGCCTAAGATCATTTTGCTGTCCTTAAACCCCCCA
GGTTCCTTCTTGCACAAATCCACTCTGCTGCCCACCTTCCCTGGCATTTTAAACAGACCTACCCCACCCCAACTCAGAGTTAAGCATACA
TGGCAATGCTGAAAATAAACAAAATCCACTGAGGCTTCCCAGGCCATTTAAAGCCTGGAGTACCAGCGCATATCATCTCATGGGGTCCAG
AGTGGAGTCCAGGCTTCTCTGAAACCAGGGCTGAGCATATTTCCATAGCCAAGGAGGTGGGACTCCCTGGAGCTATCTGTGGTCTTAGGG
AAGGATCCAGACATACACGGCTTTGGGGTACAAGCTGTGATCACTGATCAATAAATTATCTCTAGATTGGTCCTTGTGAGGGGAGTTTTA
AGAATCCAGAACATCTTGCTCTTGATCAGCACATCCAAAAACACCAAGACAAACATCCAGTGGAGCAGAACCTCTCCTGCCTCGGGAGTT
CTGACCGGGTTCCCCAGCAGGGTGTTAAGCCTCTGTCTCTGGCCCTACCAGCATCCAGGTTCCACTTTCCTAGGAGAGAGTGGAGATGGG
AAGACAGGGAAAGGAAGGCAGCAGGAGGCCACAAGCCCACCAGGTCTTCATGTCAAGAGAGGGAGTAACATGTCTTCTCATTGCCCACGG
ACCCAACCTCTGTCCAGGTGCCCCTCATCATCACAGTTTAACACAAGCTCCCCTGCTCCAGCCAAATTGATCTCCCAGTCTTGTCCTTAC
CCATTCCAAGTGCTCTGCCAGCCCCTGTTCATCCAAGTTTTAAGTCCTCCACCCTGTTCTAAGAGACTGTTCCAACGGCTCTGGGCCTCA
GTGGTCACTTGACCACCATTGTCTCAGAGCTGCCCACTTTGTGTGTGTCACATGCTGCCTGAGTCACATGTACATCTTATTTCTGCCTCT
AGTTTTGTAAGCTCCTGGAGGGCGGATAACATCTTATACTACTCTTGTATTCTCATGGCACCTAGTGCAGTGCTGGGCACAGAGTAGGTG

>55088_55088_1_MRPL4-TRIM26_MRPL4_chr19_10370369_ENST00000253099_TRIM26_chr6_30154297_ENST00000437089_length(amino acids)=298AA_BP=
MTSRGVGGCAAMLQFVRAGARAWLRPTGSQGLSSLAEEAARATENPEQVASEGLPEPVLRKVELPVPTHRRPVQAWVESLRGFEQERVGL
ADLHPDVFATAPRLDILHQVAMWQKNFKRISYAKTKTRAEVRGGGRKPWPQKGTGRARHGSIRSPLWRGGGVAHGPRGPTSYYYMLPMKV
RALGLKVALTVKLAQDDLHIMDSLELPTGDPQYLTELAHYRRWGDSVLLVDLTHEEMPQSIVEATSRLKTFNLIPAVAALAGLTLQTPLP

--------------------------------------------------------------
>55088_55088_2_MRPL4-TRIM26_MRPL4_chr19_10370369_ENST00000253099_TRIM26_chr6_30154297_ENST00000454678_length(transcript)=3444nt_BP=1378nt
AAAGTAGGCTAGGCCTACGGAAGCTGGGTCTTCTTGCTGTGAGGTCGCGTTCCCCAGTGTTACGGAGGGTCCTTGAGGCAGGAGTGAAAA
TTGGGTCTGGGGGTTAGTCCTGGGGTGGAGGTCTGGGCACGCCGGGTCGGACCCCCTCCATCTTCGGTTTTGCACACCCCGCTTTCCAGC
GCGGAGTCGCGGCGGGTAGGGCGGCGTCGCGTGCGTGACGTCATCCAGCGGCGCCTCGCGAGGCTCCAGTGGCCTTGACCTCCCGCGGCG
TGGGAGGCTGCGCGGCGATGCTGCAGTTCGTCCGGGCCGGGGCGCGGGCCTGGCTTCGGCCTACCGGCAGCCAGGGCCTGAGTTCCCTGG
CGGAAGAGGCAGCGCGTGCGACCGAGAACCCGGAGCAGGTGGCGAGCGAGGGTCTCCCGGAGCCCGTGCTGCGCAAAGTCGAGCTCCCGG
TACCCACTCATCGACGCCCAGTGCAGGCCTGGGTCGAGTCCTTGCGGGGCTTCGAGCAGGAGCGCGTGGGCCTGGCCGACCTGCACCCCG
ATGTTTTCGCCACCGCGCCCAGGCTGGACATACTGCACCAGGTTGCTATGTGGCAGAAGAACTTCAAGAGAATTAGCTATGCCAAGACCA
AGACGAGAGCCGAGGTGCGGGGCGGTGGCCGGAAGCCTTGGCCGCAGAAAGGCACTGGGCGGGCCCGGCATGGCAGCATCCGCTCTCCGC
TCTGGCGAGGAGGAGGTGTTGCCCATGGCCCCCGGGGCCCCACAAGTTACTACTACATGCTGCCCATGAAGGTGCGGGCGCTGGGTCTCA
AAGTGGCACTGACCGTCAAGCTGGCCCAGGACGACCTGCACATCATGGACTCCCTAGAGCTGCCCACCGGAGACCCACAGTACCTGACAG
AGCTGGCGCACTACCGCCGCTGGGGGGACTCCGTACTCCTCGTGGACTTAACACACGAGGAGATGCCACAGAGCATCGTGGAGGCCACCT
CTAGGCTTAAGACCTTCAACTTGATCCCGGCTGTTGCTGCTCTGGCAGGACTCACGTTACAGACCCCTCTACCCCTTCAGCCTGCCCTAC
AGCGACTTCCCCCGACCCCTACCCCACGCTACCCAGGGCCCAGCGGCCACCCCGTACCACTGTTGATGTGAAGCACCTCTTCTGAGCCAG
GCCGAGCCCCTGGCCGACTTGGGAGCCTCAGGCCCACGCCCACCCTTCGAGGAAGGTGTCACCTGGACCCCTTCATTCCACGGAGGAAGC
TGAGGCCACAGGGAGCGGCCATCGCCATTGGGAAGGGGCGACTCCACGGAAAGCCCAGACGGGCTTCTGCATCCATTCCCTCTTTTTGTT
TTTAAAATAAATTGTATTTTTGAATCAACTGCAGCTGTCAGAGGACTGGAAGTGCGTGACCTACACCAGCCTGTACAAGAGTGCCTACCT
GCACCCCCAGCAGTTTGACTGTGAGCCTGGGGTGCTAGGCAGCAAGGGCTTCACCTGGGGCAAGGTCTACTGGGAAGTGGAAGTGGAGAG
GGAGGGCTGGTCTGAGGATGAAGAAGAGGGGGATGAGGAGGAAGAGGGAGAAGAGGAGGAGGAGGAAGAGGAGGCCGGCTATGGGGATGG
ATATGACGACTGGGAAACGGACGAAGATGAGGAATCGTTGGGCGATGAAGAGGAAGAAGAGGAGGAGGAAGAGGAGGAAGTTCTGGAAAG
CTGCATGGTGGGGGTGGCTAGAGACTCTGTGAAGAGGAAGGGAGACCTCTCCCTGCGGCCAGAGGATGGCGTGTGGGCGCTGCGCCTCTC
CTCCTCCGGCATCTGGGCCAACACCAGCCCCGAGGCTGAGCTTTTCCCAGCACTGCGGCCCCGGAGAGTGGGCATCGCCCTGGATTATGA
AGGGGGCACCGTGACTTTCACCAACGCAGAGTCACAGGAACTCATCTACACCTTCACTGCCACCTTCACCCGGCGCCTGGTCCCCTTCCT
GTGGCTCAAGTGGCCAGGAACACGCCTCCTGCTAAGACCCTGAGCCCTGACATCTGCCCCCAGCCCCAACCCTCAGATGCTTCACTTCTT
TGGAATTCCAGGACTCTCAATGGGGGGACGGGATGCCTGGCCTAAGCACCTGGAGCAGGGGACCCCATATCCACTGGTAGCCACCTCCCC
ATTGCTGTGGCCCCCTGAAATCTCACTCAGTGCTGTTGCTCCATCTACTGCCCTAATGGGGCTCTTTTCCCACCTCCTGCTGGTTTCCCG
AGGGAACTTCTGACCCTGGAGTCCATGAGGGCTCCTTTCCTTTTTGACCACGACCTTGGCCCCAGCTCTGCACTCTCTGGAATAAGGGCC
CGATGCAGCATTTTCTTGCCCAGTGTGGCAAGACCTCAGAAAAACCAGTCAATTACGCCTAAGATCATTTTGCTGTCCTTAAACCCCCCA
GGTTCCTTCTTGCACAAATCCACTCTGCTGCCCACCTTCCCTGGCATTTTAAACAGACCTACCCCACCCCAACTCAGAGTTAAGCATACA
TGGCAATGCTGAAAATAAACAAAATCCACTGAGGCTTCCCAGGCCATTTAAAGCCTGGAGTACCAGCGCATATCATCTCATGGGGTCCAG
AGTGGAGTCCAGGCTTCTCTGAAACCAGGGCTGAGCATATTTCCATAGCCAAGGAGGTGGGACTCCCTGGAGCTATCTGTGGTCTTAGGG
AAGGATCCAGACATACACGGCTTTGGGGTACAAGCTGTGATCACTGATCAATAAATTATCTCTAGATTGGTCCTTGTGAGGGGAGTTTTA
AGAATCCAGAACATCTTGCTCTTGATCAGCACATCCAAAAACACCAAGACAAACATCCAGTGGAGCAGAACCTCTCCTGCCTCGGGAGTT
CTGACCGGGTTCCCCAGCAGGGTGTTAAGCCTCTGTCTCTGGCCCTACCAGCATCCAGGTTCCACTTTCCTAGGAGAGAGTGGAGATGGG
AAGACAGGGAAAGGAAGGCAGCAGGAGGCCACAAGCCCACCAGGTCTTCATGTCAAGAGAGGGAGTAACATGTCTTCTCATTGCCCACGG
ACCCAACCTCTGTCCAGGTGCCCCTCATCATCACAGTTTAACACAAGCTCCCCTGCTCCAGCCAAATTGATCTCCCAGTCTTGTCCTTAC
CCATTCCAAGTGCTCTGCCAGCCCCTGTTCATCCAAGTTTTAAGTCCTCCACCCTGTTCTAAGAGACTGTTCCAACGGCTCTGGGCCTCA
GTGGTCACTTGACCACCATTGTCTCAGAGCTGCCCACTTTGTGTGTGTCACATGCTGCCTGAGTCACATGTACATCTTATTTCTGCCTCT
AGTTTTGTAAGCTCCTGGAGGGCGGATAACATCTTATACTACTCTTGTATTCTCATGGCACCTAGTGCAGTGCTGGGCACAGAGTAGGTG

>55088_55088_2_MRPL4-TRIM26_MRPL4_chr19_10370369_ENST00000253099_TRIM26_chr6_30154297_ENST00000454678_length(amino acids)=298AA_BP=
MTSRGVGGCAAMLQFVRAGARAWLRPTGSQGLSSLAEEAARATENPEQVASEGLPEPVLRKVELPVPTHRRPVQAWVESLRGFEQERVGL
ADLHPDVFATAPRLDILHQVAMWQKNFKRISYAKTKTRAEVRGGGRKPWPQKGTGRARHGSIRSPLWRGGGVAHGPRGPTSYYYMLPMKV
RALGLKVALTVKLAQDDLHIMDSLELPTGDPQYLTELAHYRRWGDSVLLVDLTHEEMPQSIVEATSRLKTFNLIPAVAALAGLTLQTPLP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MRPL4-TRIM26


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MRPL4-TRIM26


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MRPL4-TRIM26


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource