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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MRPS18B-EIF3A (FusionGDB2 ID:55144)

Fusion Gene Summary for MRPS18B-EIF3A

check button Fusion gene summary
Fusion gene informationFusion gene name: MRPS18B-EIF3A
Fusion gene ID: 55144
HgeneTgene
Gene symbol

MRPS18B

EIF3A

Gene ID

28973

8661

Gene namemitochondrial ribosomal protein S18Beukaryotic translation initiation factor 3 subunit A
SynonymsC6orf14|HSPC183|HumanS18a|MRP-S18-2|MRPS18-2|PTD017|S18amtEIF3|EIF3S10|P167|TIF32|eIF3-p170|eIF3-theta|p180|p185
Cytomap

6p21.33

10q26.11

Type of geneprotein-codingprotein-coding
Description28S ribosomal protein S18b, mitochondrial28S ribosomal protein S18-2, mitochondrialMRP-S18-bS18mt-bmitochondrial ribosomal protein S18-2mitochondrial small ribosomal subunit protein bS18bmitochondrial small ribosomal subunit protein bS18m-Bmitochoneukaryotic translation initiation factor 3 subunit AEIF3, p180 subunitcentrosomin homologcytoplasmic protein p167eIF-3-thetaeIF3 p167eIF3 p180eIF3 p185eukaryotic translation initiation factor 3 subunit 10eukaryotic translation initiation factor 3
Modification date2020032020200313
UniProtAcc

Q9Y676

Q14152

Ensembl transtripts involved in fusion geneENST00000259873, ENST00000472229, 
ENST00000506373, ENST00000327800, 
ENST00000400594, ENST00000412451, 
ENST00000412843, ENST00000418070, 
ENST00000426945, ENST00000428224, 
ENST00000430402, ENST00000437247, 
ENST00000440992, ENST00000451032, 
ENST00000454427, ENST00000468755, 
ENST00000469397, ENST00000472444, 
ENST00000477010, ENST00000489289, 
ENST00000493769, 		ENST00000369144, 
ENST00000541549, 
Fusion gene scores* DoF score4 X 3 X 2=248 X 9 X 3=216
# samples 49
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MRPS18B [Title/Abstract] AND EIF3A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMRPS18B(30593886)-EIF3A(120808602), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneEIF3A

GO:0001732

formation of cytoplasmic translation initiation complex

17581632

TgeneEIF3A

GO:0075522

IRES-dependent viral translational initiation

9573242|23766293|24357634

TgeneEIF3A

GO:0075525

viral translational termination-reinitiation

21347434


check buttonFusion gene breakpoints across MRPS18B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across EIF3A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAI420562MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+


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Fusion Gene ORF analysis for MRPS18B-EIF3A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000259873ENST00000369144MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
3UTR-intronENST00000259873ENST00000541549MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
3UTR-intronENST00000472229ENST00000369144MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
3UTR-intronENST00000472229ENST00000541549MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
3UTR-intronENST00000506373ENST00000369144MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
3UTR-intronENST00000506373ENST00000541549MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000327800ENST00000369144MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000327800ENST00000541549MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000400594ENST00000369144MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000400594ENST00000541549MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000412451ENST00000369144MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000412451ENST00000541549MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000412843ENST00000369144MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000412843ENST00000541549MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000418070ENST00000369144MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000418070ENST00000541549MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000426945ENST00000369144MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000426945ENST00000541549MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000428224ENST00000369144MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000428224ENST00000541549MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000430402ENST00000369144MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000430402ENST00000541549MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000437247ENST00000369144MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000437247ENST00000541549MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000440992ENST00000369144MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000440992ENST00000541549MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000451032ENST00000369144MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000451032ENST00000541549MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000454427ENST00000369144MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000454427ENST00000541549MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000468755ENST00000369144MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000468755ENST00000541549MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000469397ENST00000369144MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000469397ENST00000541549MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000472444ENST00000369144MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000472444ENST00000541549MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000477010ENST00000369144MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000477010ENST00000541549MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000489289ENST00000369144MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000489289ENST00000541549MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000493769ENST00000369144MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+
intron-intronENST00000493769ENST00000541549MRPS18Bchr6

30593886

-EIF3Achr10

120808602

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MRPS18B-EIF3A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MRPS18B-EIF3A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:30593886/:120808602)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MRPS18B

Q9Y676

EIF3A

Q14152

FUNCTION: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269|PubMed:23766293, ECO:0000269|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MRPS18B-EIF3A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MRPS18B-EIF3A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MRPS18B-EIF3A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MRPS18B-EIF3A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource