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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MRPS35-LYRM5 (FusionGDB2 ID:55210)

Fusion Gene Summary for MRPS35-LYRM5

check button Fusion gene summary
Fusion gene informationFusion gene name: MRPS35-LYRM5
Fusion gene ID: 55210
HgeneTgene
Gene symbol

MRPS35

LYRM5

Gene ID

60488

144363

Gene namemitochondrial ribosomal protein S35electron transfer flavoprotein regulatory factor 1
SynonymsHDCMD11P|MDS023|MRP-S28|MRPS28LYRM5
Cytomap

12p11.22

12p12.1

Type of geneprotein-codingprotein-coding
Description28S ribosomal protein S35, mitochondrial28S ribosomal protein S28, mitochondrialMRP-S35S28mtS35mtmitochondrial ribosomal protein S28mitochondrial small ribosomal subunit protein mS35electron transfer flavoprotein regulatory factor 1LYR motif containing 5LYR motif-containing protein 5
Modification date2020031320200313
UniProtAcc

P82673

.
Ensembl transtripts involved in fusion geneENST00000081029, ENST00000538315, 
ENST00000554266, ENST00000556351, 
ENST00000556402, ENST00000556927, 
ENST00000381356, ENST00000553788, 
ENST00000555711, ENST00000556885, 
ENST00000557540, ENST00000555151, 
Fusion gene scores* DoF score8 X 7 X 7=3923 X 3 X 2=18
# samples 104
** MAII scorelog2(10/392*10)=-1.97085365434048
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MRPS35 [Title/Abstract] AND LYRM5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMRPS35(27869391)-LYRM5(25356854), # samples:2
Anticipated loss of major functional domain due to fusion event.MRPS35-LYRM5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MRPS35 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LYRM5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-IP-7968-01AMRPS35chr12

27869391

-LYRM5chr12

25356854

+
ChimerDB4STADTCGA-IP-7968-01AMRPS35chr12

27869391

+LYRM5chr12

25356854

+
ChimerDB4STADTCGA-IP-7968-01AMRPS35chr12

27869391

+LYRM5chr12

25357025

+


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Fusion Gene ORF analysis for MRPS35-LYRM5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000081029ENST00000554266MRPS35chr12

27869391

+LYRM5chr12

25357025

+
5CDS-3UTRENST00000081029ENST00000556351MRPS35chr12

27869391

+LYRM5chr12

25357025

+
5CDS-3UTRENST00000081029ENST00000556402MRPS35chr12

27869391

+LYRM5chr12

25357025

+
5CDS-3UTRENST00000081029ENST00000556927MRPS35chr12

27869391

+LYRM5chr12

25357025

+
5CDS-3UTRENST00000538315ENST00000554266MRPS35chr12

27869391

+LYRM5chr12

25357025

+
5CDS-3UTRENST00000538315ENST00000556351MRPS35chr12

27869391

+LYRM5chr12

25357025

+
5CDS-3UTRENST00000538315ENST00000556402MRPS35chr12

27869391

+LYRM5chr12

25357025

+
5CDS-3UTRENST00000538315ENST00000556927MRPS35chr12

27869391

+LYRM5chr12

25357025

+
5CDS-5UTRENST00000081029ENST00000381356MRPS35chr12

27869391

+LYRM5chr12

25356854

+
5CDS-5UTRENST00000081029ENST00000553788MRPS35chr12

27869391

+LYRM5chr12

25356854

+
5CDS-5UTRENST00000081029ENST00000554266MRPS35chr12

27869391

+LYRM5chr12

25356854

+
5CDS-5UTRENST00000081029ENST00000555711MRPS35chr12

27869391

+LYRM5chr12

25356854

+
5CDS-5UTRENST00000081029ENST00000556351MRPS35chr12

27869391

+LYRM5chr12

25356854

+
5CDS-5UTRENST00000081029ENST00000556402MRPS35chr12

27869391

+LYRM5chr12

25356854

+
5CDS-5UTRENST00000081029ENST00000556885MRPS35chr12

27869391

+LYRM5chr12

25356854

+
5CDS-5UTRENST00000081029ENST00000556927MRPS35chr12

27869391

+LYRM5chr12

25356854

+
5CDS-5UTRENST00000081029ENST00000557540MRPS35chr12

27869391

+LYRM5chr12

25356854

+
5CDS-5UTRENST00000538315ENST00000381356MRPS35chr12

27869391

+LYRM5chr12

25356854

+
5CDS-5UTRENST00000538315ENST00000553788MRPS35chr12

27869391

+LYRM5chr12

25356854

+
5CDS-5UTRENST00000538315ENST00000554266MRPS35chr12

27869391

+LYRM5chr12

25356854

+
5CDS-5UTRENST00000538315ENST00000555711MRPS35chr12

27869391

+LYRM5chr12

25356854

+
5CDS-5UTRENST00000538315ENST00000556351MRPS35chr12

27869391

+LYRM5chr12

25356854

+
5CDS-5UTRENST00000538315ENST00000556402MRPS35chr12

27869391

+LYRM5chr12

25356854

+
5CDS-5UTRENST00000538315ENST00000556885MRPS35chr12

27869391

+LYRM5chr12

25356854

+
5CDS-5UTRENST00000538315ENST00000556927MRPS35chr12

27869391

+LYRM5chr12

25356854

+
5CDS-5UTRENST00000538315ENST00000557540MRPS35chr12

27869391

+LYRM5chr12

25356854

+
5CDS-intronENST00000081029ENST00000553788MRPS35chr12

27869391

+LYRM5chr12

25357025

+
5CDS-intronENST00000081029ENST00000555151MRPS35chr12

27869391

+LYRM5chr12

25356854

+
5CDS-intronENST00000081029ENST00000555151MRPS35chr12

27869391

+LYRM5chr12

25357025

+
5CDS-intronENST00000538315ENST00000553788MRPS35chr12

27869391

+LYRM5chr12

25357025

+
5CDS-intronENST00000538315ENST00000555151MRPS35chr12

27869391

+LYRM5chr12

25356854

+
5CDS-intronENST00000538315ENST00000555151MRPS35chr12

27869391

+LYRM5chr12

25357025

+
Frame-shiftENST00000081029ENST00000556885MRPS35chr12

27869391

+LYRM5chr12

25357025

+
Frame-shiftENST00000081029ENST00000557540MRPS35chr12

27869391

+LYRM5chr12

25357025

+
Frame-shiftENST00000538315ENST00000556885MRPS35chr12

27869391

+LYRM5chr12

25357025

+
Frame-shiftENST00000538315ENST00000557540MRPS35chr12

27869391

+LYRM5chr12

25357025

+
In-frameENST00000081029ENST00000381356MRPS35chr12

27869391

+LYRM5chr12

25357025

+
In-frameENST00000081029ENST00000555711MRPS35chr12

27869391

+LYRM5chr12

25357025

+
In-frameENST00000538315ENST00000381356MRPS35chr12

27869391

+LYRM5chr12

25357025

+
In-frameENST00000538315ENST00000555711MRPS35chr12

27869391

+LYRM5chr12

25357025

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000081029MRPS35chr1227869391+ENST00000381356LYRM5chr1225357025+131639223613196
ENST00000081029MRPS35chr1227869391+ENST00000555711LYRM5chr1225357025+98439223448141
ENST00000538315MRPS35chr1227869391+ENST00000381356LYRM5chr1225357025+12543309551180
ENST00000538315MRPS35chr1227869391+ENST00000555711LYRM5chr1225357025+9223309386125

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000081029ENST00000381356MRPS35chr1227869391+LYRM5chr1225357025+0.0009639590.9990361
ENST00000081029ENST00000555711MRPS35chr1227869391+LYRM5chr1225357025+0.0317602570.9682397
ENST00000538315ENST00000381356MRPS35chr1227869391+LYRM5chr1225357025+0.0008209230.99917907
ENST00000538315ENST00000555711MRPS35chr1227869391+LYRM5chr1225357025+0.0293514320.9706486

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Fusion Genomic Features for MRPS35-LYRM5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MRPS35-LYRM5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:27869391/chr12:25356854)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MRPS35

P82673

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMRPS35chr12:27869391chr12:25357025ENST00000081029+38257_321107324.0Coiled coilOntology_term=ECO:0000255
HgeneMRPS35chr12:27869391chr12:25357025ENST00000538315+37257_321107526.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for MRPS35-LYRM5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>55210_55210_1_MRPS35-LYRM5_MRPS35_chr12_27869391_ENST00000081029_LYRM5_chr12_25357025_ENST00000381356_length(transcript)=1316nt_BP=392nt
GCTTAGCGGCCCCAGGCCCGCCCCTGACACTGAACGCCGCTTGTCCCCTCCGGCTTGCCGTCCTCGCAGCCATGGCGGCCGCCGCGCTCC
CAGCATGGCTGTCTCTGCAGTCGAGGGCAAGGACTCTGCGTGCATTCTCCACTGCCGTCTACTCGGCCACTCCGGTCCCGACACCTAGCC
TGCCGGAAAGAACACCCGGAAATGAAAGGCCACCAAGAAGAAAGGCACTACCTCCTAGGACAGAGAAAATGGCTGTTGACCAGGACTGGC
CTAGTGTTTACCCAGTTGCAGCACCATTTAAACCCTCTGCAGTACCTCTTCCTGTTCGAATGGGTTATCCAGTAAAAAAGGGCGTGCCCA
TGGCAAAGGAGGGAAATCTAGAACTTTTAAAGCTGCTGTATCTTGGACGAGACTATCCAAAAGGAGCAGACTATTTTAAAAAGCGTTTGA
AGAACATTTTCCTTAAAAACAAAGATGTGAAGAATCCAGAGAAGATCAAAGAACTTATTGCACAGGGCGAATTTGTAATGAAAGAGCTAG
AAGCTTTGTACTTCCTTAGGAAATACAGAGCTATGAAACAACGCTATTATTCAGATACCAACAAAACTAATTGATCATTACTACTTTAAT
TTAGCTATCAGTGCCAGCTGTTTATGTATACCAGATGTTGTAAAATAATTCTAACTTAAAATGGGAAGATATACATGTTGTGTAAAAAAT
CCCTGAGCTGCCCTACTGAACTAAATAGGTTTCAACTTCTGTTCATACGGAGAAAGTATCAGCAACTTTATGCTCAATTTTGATACAAAC
ATAGCAATTTAGCTATACTACCGATCATAAATTAATGAGCACCCAATTTTGAATGAAAATATAATACACTTAATCCTCTAACTTAATAGG
ACTTAGCCAATTATTTTTAGCTTATTTCTCCATTTTACTGACAAGAGAATGCCATTTACCGAACATTTAATAAGCAAAATAATTTCTTAC
ACACTTACTTCTCTTAACTTTTGAAAGGAATCCCTTATTTTTTCACCCAATTTGGTATATTAACAGCACATACTCAAGGTTCACTACAAA
ACAAACAGTTCCTGGTAATGATTTAAATGTAGTTATAGAAATAAATAATATGTATGGAGTCATTACTTCTGACCTTGAAATAGCCTGCTG
GTGACTGGCATTAACATACATAACTAACTATTCAATTATTTCCATTATTAATGTTGCTGCTGCTACCTTTGGGCCTAAAACCAAGTCACC

>55210_55210_1_MRPS35-LYRM5_MRPS35_chr12_27869391_ENST00000081029_LYRM5_chr12_25357025_ENST00000381356_length(amino acids)=196AA_BP=121
MTLNAACPLRLAVLAAMAAAALPAWLSLQSRARTLRAFSTAVYSATPVPTPSLPERTPGNERPPRRKALPPRTEKMAVDQDWPSVYPVAA
PFKPSAVPLPVRMGYPVKKGVPMAKEGNLELLKLLYLGRDYPKGADYFKKRLKNIFLKNKDVKNPEKIKELIAQGEFVMKELEALYFLRK

--------------------------------------------------------------
>55210_55210_2_MRPS35-LYRM5_MRPS35_chr12_27869391_ENST00000081029_LYRM5_chr12_25357025_ENST00000555711_length(transcript)=984nt_BP=392nt
GCTTAGCGGCCCCAGGCCCGCCCCTGACACTGAACGCCGCTTGTCCCCTCCGGCTTGCCGTCCTCGCAGCCATGGCGGCCGCCGCGCTCC
CAGCATGGCTGTCTCTGCAGTCGAGGGCAAGGACTCTGCGTGCATTCTCCACTGCCGTCTACTCGGCCACTCCGGTCCCGACACCTAGCC
TGCCGGAAAGAACACCCGGAAATGAAAGGCCACCAAGAAGAAAGGCACTACCTCCTAGGACAGAGAAAATGGCTGTTGACCAGGACTGGC
CTAGTGTTTACCCAGTTGCAGCACCATTTAAACCCTCTGCAGTACCTCTTCCTGTTCGAATGGGTTATCCAGTAAAAAAGGGCGTGCCCA
TGGCAAAGGAGGGAAATCTAGAACTTTTAAAGTGCTGTATCTTGGACGAGACTATCCAAAAGGAGCAGACTATTTTAAAAAGCGTTTGAA
GAACATTTTCCTTAAAAACAAAGATGTGAAGAATCCAGAGAAGATCAAAGAACTTATTGCACAGGGCGAATTTGTAATGAAAGAGCTAGA
AGCTTTGTACTTCCTTAGGAAATACAGAGCTATGAAACAACGCTATTATTCAGATACCAACAAAACTAATTGATCATTACTACTTTAATT
TAGCTATCAGTGCCAGCTGTTTATGTATACCAGATGTTGTAAAATAATTCTAACTTAAAATGGGAAGATATACATGTTGTGTAAAAAATC
CCTGAGCTGCCCTACTGAACTAAATAGGTTTCAACTTCTGTTCATACGGAGAAAGTATCAGCAACTTTATGCTCAATTTTGATACAAACA
TAGCAATTTAGCTATACTACCGATCATAAATTAATGAGCACCCAATTTTGAATGAAAATATAATACACTTAATCCTCTAACTTAATAGGA

>55210_55210_2_MRPS35-LYRM5_MRPS35_chr12_27869391_ENST00000081029_LYRM5_chr12_25357025_ENST00000555711_length(amino acids)=141AA_BP=123
MTLNAACPLRLAVLAAMAAAALPAWLSLQSRARTLRAFSTAVYSATPVPTPSLPERTPGNERPPRRKALPPRTEKMAVDQDWPSVYPVAA

--------------------------------------------------------------
>55210_55210_3_MRPS35-LYRM5_MRPS35_chr12_27869391_ENST00000538315_LYRM5_chr12_25357025_ENST00000381356_length(transcript)=1254nt_BP=330nt
CTCGCAGCCATGGCGGCCGCCGCGCTCCCAGCATGGCTGTCTCTGCAGTCGAGGGCAAGGACTCTGCGTGCATTCTCCACTGCCGTCTAC
TCGGCCACTCCGGTCCCGACACCTAGCCTGCCGGAAAGAACACCCGGAAATGAAAGGCCACCAAGAAGAAAGGCACTACCTCCTAGGACA
GAGAAAATGGCTGTTGACCAGGACTGGCCTAGTGTTTACCCAGTTGCAGCACCATTTAAACCCTCTGCAGTACCTCTTCCTGTTCGAATG
GGTTATCCAGTAAAAAAGGGCGTGCCCATGGCAAAGGAGGGAAATCTAGAACTTTTAAAGCTGCTGTATCTTGGACGAGACTATCCAAAA
GGAGCAGACTATTTTAAAAAGCGTTTGAAGAACATTTTCCTTAAAAACAAAGATGTGAAGAATCCAGAGAAGATCAAAGAACTTATTGCA
CAGGGCGAATTTGTAATGAAAGAGCTAGAAGCTTTGTACTTCCTTAGGAAATACAGAGCTATGAAACAACGCTATTATTCAGATACCAAC
AAAACTAATTGATCATTACTACTTTAATTTAGCTATCAGTGCCAGCTGTTTATGTATACCAGATGTTGTAAAATAATTCTAACTTAAAAT
GGGAAGATATACATGTTGTGTAAAAAATCCCTGAGCTGCCCTACTGAACTAAATAGGTTTCAACTTCTGTTCATACGGAGAAAGTATCAG
CAACTTTATGCTCAATTTTGATACAAACATAGCAATTTAGCTATACTACCGATCATAAATTAATGAGCACCCAATTTTGAATGAAAATAT
AATACACTTAATCCTCTAACTTAATAGGACTTAGCCAATTATTTTTAGCTTATTTCTCCATTTTACTGACAAGAGAATGCCATTTACCGA
ACATTTAATAAGCAAAATAATTTCTTACACACTTACTTCTCTTAACTTTTGAAAGGAATCCCTTATTTTTTCACCCAATTTGGTATATTA
ACAGCACATACTCAAGGTTCACTACAAAACAAACAGTTCCTGGTAATGATTTAAATGTAGTTATAGAAATAAATAATATGTATGGAGTCA
TTACTTCTGACCTTGAAATAGCCTGCTGGTGACTGGCATTAACATACATAACTAACTATTCAATTATTTCCATTATTAATGTTGCTGCTG

>55210_55210_3_MRPS35-LYRM5_MRPS35_chr12_27869391_ENST00000538315_LYRM5_chr12_25357025_ENST00000381356_length(amino acids)=180AA_BP=105
MAAAALPAWLSLQSRARTLRAFSTAVYSATPVPTPSLPERTPGNERPPRRKALPPRTEKMAVDQDWPSVYPVAAPFKPSAVPLPVRMGYP
VKKGVPMAKEGNLELLKLLYLGRDYPKGADYFKKRLKNIFLKNKDVKNPEKIKELIAQGEFVMKELEALYFLRKYRAMKQRYYSDTNKTN

--------------------------------------------------------------
>55210_55210_4_MRPS35-LYRM5_MRPS35_chr12_27869391_ENST00000538315_LYRM5_chr12_25357025_ENST00000555711_length(transcript)=922nt_BP=330nt
CTCGCAGCCATGGCGGCCGCCGCGCTCCCAGCATGGCTGTCTCTGCAGTCGAGGGCAAGGACTCTGCGTGCATTCTCCACTGCCGTCTAC
TCGGCCACTCCGGTCCCGACACCTAGCCTGCCGGAAAGAACACCCGGAAATGAAAGGCCACCAAGAAGAAAGGCACTACCTCCTAGGACA
GAGAAAATGGCTGTTGACCAGGACTGGCCTAGTGTTTACCCAGTTGCAGCACCATTTAAACCCTCTGCAGTACCTCTTCCTGTTCGAATG
GGTTATCCAGTAAAAAAGGGCGTGCCCATGGCAAAGGAGGGAAATCTAGAACTTTTAAAGTGCTGTATCTTGGACGAGACTATCCAAAAG
GAGCAGACTATTTTAAAAAGCGTTTGAAGAACATTTTCCTTAAAAACAAAGATGTGAAGAATCCAGAGAAGATCAAAGAACTTATTGCAC
AGGGCGAATTTGTAATGAAAGAGCTAGAAGCTTTGTACTTCCTTAGGAAATACAGAGCTATGAAACAACGCTATTATTCAGATACCAACA
AAACTAATTGATCATTACTACTTTAATTTAGCTATCAGTGCCAGCTGTTTATGTATACCAGATGTTGTAAAATAATTCTAACTTAAAATG
GGAAGATATACATGTTGTGTAAAAAATCCCTGAGCTGCCCTACTGAACTAAATAGGTTTCAACTTCTGTTCATACGGAGAAAGTATCAGC
AACTTTATGCTCAATTTTGATACAAACATAGCAATTTAGCTATACTACCGATCATAAATTAATGAGCACCCAATTTTGAATGAAAATATA
ATACACTTAATCCTCTAACTTAATAGGACTTAGCCAATTATTTTTAGCTTATTTCTCCATTTTACTGACAAGAGAATGCCATTTACCGAA

>55210_55210_4_MRPS35-LYRM5_MRPS35_chr12_27869391_ENST00000538315_LYRM5_chr12_25357025_ENST00000555711_length(amino acids)=125AA_BP=107
MAAAALPAWLSLQSRARTLRAFSTAVYSATPVPTPSLPERTPGNERPPRRKALPPRTEKMAVDQDWPSVYPVAAPFKPSAVPLPVRMGYP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MRPS35-LYRM5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MRPS35-LYRM5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MRPS35-LYRM5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource