FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MRRF-GLIS3 (FusionGDB2 ID:55234)

Fusion Gene Summary for MRRF-GLIS3

check button Fusion gene summary
Fusion gene informationFusion gene name: MRRF-GLIS3
Fusion gene ID: 55234
HgeneTgene
Gene symbol

MRRF

GLIS3

Gene ID

92399

169792

Gene namemitochondrial ribosome recycling factorGLIS family zinc finger 3
SynonymsMRFF|MTRRF|RRFNDH|ZNF515
Cytomap

9q33.2

9p24.2

Type of geneprotein-codingprotein-coding
Descriptionribosome-recycling factor, mitochondrialribosome-releasing factor, mitochondrialzinc finger protein GLIS3GLI-similar 3OK/KNS-cl.4zinc finger protein 515
Modification date2020031320200313
UniProtAcc.

Q8NEA6

Ensembl transtripts involved in fusion geneENST00000297908, ENST00000344641, 
ENST00000373729, ENST00000373723, 
ENST00000373724, ENST00000373730, 
ENST00000394315, ENST00000546115, 
ENST00000461870, ENST00000324333, 
ENST00000381971, 
Fusion gene scores* DoF score6 X 4 X 6=14410 X 7 X 7=490
# samples 610
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/490*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MRRF [Title/Abstract] AND GLIS3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMRRF(125075665)-GLIS3(3937189), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMRRF

GO:0032790

ribosome disassembly

19716793


check buttonFusion gene breakpoints across MRRF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GLIS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-4436-01AMRRFchr9

125075665

+GLIS3chr9

3937189

-


Top

Fusion Gene ORF analysis for MRRF-GLIS3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000297908ENST00000461870MRRFchr9

125075665

+GLIS3chr9

3937189

-
5CDS-5UTRENST00000344641ENST00000461870MRRFchr9

125075665

+GLIS3chr9

3937189

-
5CDS-5UTRENST00000373729ENST00000461870MRRFchr9

125075665

+GLIS3chr9

3937189

-
In-frameENST00000297908ENST00000324333MRRFchr9

125075665

+GLIS3chr9

3937189

-
In-frameENST00000297908ENST00000381971MRRFchr9

125075665

+GLIS3chr9

3937189

-
In-frameENST00000344641ENST00000324333MRRFchr9

125075665

+GLIS3chr9

3937189

-
In-frameENST00000344641ENST00000381971MRRFchr9

125075665

+GLIS3chr9

3937189

-
In-frameENST00000373729ENST00000324333MRRFchr9

125075665

+GLIS3chr9

3937189

-
In-frameENST00000373729ENST00000381971MRRFchr9

125075665

+GLIS3chr9

3937189

-
intron-3CDSENST00000373723ENST00000324333MRRFchr9

125075665

+GLIS3chr9

3937189

-
intron-3CDSENST00000373723ENST00000381971MRRFchr9

125075665

+GLIS3chr9

3937189

-
intron-3CDSENST00000373724ENST00000324333MRRFchr9

125075665

+GLIS3chr9

3937189

-
intron-3CDSENST00000373724ENST00000381971MRRFchr9

125075665

+GLIS3chr9

3937189

-
intron-3CDSENST00000373730ENST00000324333MRRFchr9

125075665

+GLIS3chr9

3937189

-
intron-3CDSENST00000373730ENST00000381971MRRFchr9

125075665

+GLIS3chr9

3937189

-
intron-3CDSENST00000394315ENST00000324333MRRFchr9

125075665

+GLIS3chr9

3937189

-
intron-3CDSENST00000394315ENST00000381971MRRFchr9

125075665

+GLIS3chr9

3937189

-
intron-3CDSENST00000546115ENST00000324333MRRFchr9

125075665

+GLIS3chr9

3937189

-
intron-3CDSENST00000546115ENST00000381971MRRFchr9

125075665

+GLIS3chr9

3937189

-
intron-5UTRENST00000373723ENST00000461870MRRFchr9

125075665

+GLIS3chr9

3937189

-
intron-5UTRENST00000373724ENST00000461870MRRFchr9

125075665

+GLIS3chr9

3937189

-
intron-5UTRENST00000373730ENST00000461870MRRFchr9

125075665

+GLIS3chr9

3937189

-
intron-5UTRENST00000394315ENST00000461870MRRFchr9

125075665

+GLIS3chr9

3937189

-
intron-5UTRENST00000546115ENST00000461870MRRFchr9

125075665

+GLIS3chr9

3937189

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000297908MRRFchr9125075665+ENST00000381971GLIS3chr93937189-25769192832001572
ENST00000297908MRRFchr9125075665+ENST00000324333GLIS3chr93937189-61479192832001572
ENST00000344641MRRFchr9125075665+ENST00000381971GLIS3chr93937189-267910222302104624
ENST00000344641MRRFchr9125075665+ENST00000324333GLIS3chr93937189-625010222302104624
ENST00000373729MRRFchr9125075665+ENST00000381971GLIS3chr93937189-2342685641767567
ENST00000373729MRRFchr9125075665+ENST00000324333GLIS3chr93937189-5913685641767567

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000297908ENST00000381971MRRFchr9125075665+GLIS3chr93937189-0.0283399540.97166
ENST00000297908ENST00000324333MRRFchr9125075665+GLIS3chr93937189-0.0030266130.9969734
ENST00000344641ENST00000381971MRRFchr9125075665+GLIS3chr93937189-0.012111940.98788804
ENST00000344641ENST00000324333MRRFchr9125075665+GLIS3chr93937189-0.0015752320.99842477
ENST00000373729ENST00000381971MRRFchr9125075665+GLIS3chr93937189-0.0061600490.9938399
ENST00000373729ENST00000324333MRRFchr9125075665+GLIS3chr93937189-0.0005264430.99947363

Top

Fusion Genomic Features for MRRF-GLIS3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for MRRF-GLIS3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:125075665/chr9:3937189)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GLIS3

Q8NEA6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGLIS3chr9:125075665chr9:3937189ENST00000324333210491_507415776.0MotifBipartite nuclear localization signal
TgeneGLIS3chr9:125075665chr9:3937189ENST00000324333210412_436415776.0Zinc fingerC2H2-type 3
TgeneGLIS3chr9:125075665chr9:3937189ENST00000324333210442_466415776.0Zinc fingerC2H2-type 4
TgeneGLIS3chr9:125075665chr9:3937189ENST00000324333210472_496415776.0Zinc fingerC2H2-type 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGLIS3chr9:125075665chr9:3937189ENST00000324333210289_306415776.0Compositional biasNote=Pro-rich
TgeneGLIS3chr9:125075665chr9:3937189ENST0000032433321041_154415776.0Compositional biasNote=Ser-rich
TgeneGLIS3chr9:125075665chr9:3937189ENST00000381971311289_306570931.0Compositional biasNote=Pro-rich
TgeneGLIS3chr9:125075665chr9:3937189ENST0000038197131141_154570931.0Compositional biasNote=Ser-rich
TgeneGLIS3chr9:125075665chr9:3937189ENST00000381971311491_507570931.0MotifBipartite nuclear localization signal
TgeneGLIS3chr9:125075665chr9:3937189ENST00000324333210345_370415776.0Zinc fingerC2H2-type 1
TgeneGLIS3chr9:125075665chr9:3937189ENST00000324333210379_406415776.0Zinc fingerC2H2-type 2%3B atypical
TgeneGLIS3chr9:125075665chr9:3937189ENST00000381971311345_370570931.0Zinc fingerC2H2-type 1
TgeneGLIS3chr9:125075665chr9:3937189ENST00000381971311379_406570931.0Zinc fingerC2H2-type 2%3B atypical
TgeneGLIS3chr9:125075665chr9:3937189ENST00000381971311412_436570931.0Zinc fingerC2H2-type 3
TgeneGLIS3chr9:125075665chr9:3937189ENST00000381971311442_466570931.0Zinc fingerC2H2-type 4
TgeneGLIS3chr9:125075665chr9:3937189ENST00000381971311472_496570931.0Zinc fingerC2H2-type 5


Top

Fusion Gene Sequence for MRRF-GLIS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>55234_55234_1_MRRF-GLIS3_MRRF_chr9_125075665_ENST00000297908_GLIS3_chr9_3937189_ENST00000324333_length(transcript)=6147nt_BP=919nt
ACAGGACAATCCGGGGCGGGGCCTGAGATGCAGTCCTGCGAGGGCGGCCTCCTGTAAGACCTCTTAGCGGGCCCATCGCTGAGGTGCAGG
GACATGTCGCGGCCGAACTCACCTCGTGGCCTCGGCGTGGTGCTCTCAGCTCATGCCCGGAAACCAGGTCCCGACGCCGCGGTCAGACGG
ACCTCTAGACGCGTCCGCCTCAATGCCGCCAGCTGCCAGGCCGCCCGTGACGCGTTAAGCCTGCGCCGCCTCCTGGCTTCGTGACGTCAC
GACGTCCGCGCAGCTGCGGTCGCCGCCGTCGCACGAGTCTTTCCTTAGTAACCTGGGCGATAGCTGTGGATGTTTCCAAGGATTGTCTTC
AGTCATGGCCTTGGGATTAAAGTGCTTCCGCATGGTCCACCCTACCTTTCGCAATTATCTTGCAGCCTCTATCAGACCCGTTTCAGAAGT
TACACTGAAGACAGTGCATGAAAGACAACATGGCCATAGGCAATACATGGCCTATTCAGCTGTACCAGTCCGCCATTTTGCTACCAAGAA
AGCCAAAGGATCCCTTGACAAGATTGCTGTGGTAACTGCTGACGGGAAGCTTGCTTTAAACCAGATTAGCCAGATCTCCATGAAGTCGCC
ACAGCTGATTTTGGTGAATATGGCCAGCTTCCCAGAGTGTACAGCTGCAGCTATCAAGGCTATAAGAGAAAGTGGAATGAATCTGAACCC
AGAAGTGGAAGGGACGCTAATTCGGGTACCCATTCCCCAAGTAACCAGAGAGCACAGAGAAATGCTGGTGAAACTGGCCAAACAGAACAC
CAACAAGGCCAAAGACTCTTTACGGAAGGTTCGCACCAACTCAATGAACAAGCTGAAGAAATCCAAGGATACAGTCTCAGAGGACACCAT
TAGGCTAATAGAGAAACAGTTTGAAGGTTGCGAGAAGGCCTTTTCAAGGCTTGAAAATCTCAAGATCCACTTGCGGAGCCACACAGGCGA
GAAGCCGTATTTGTGCCAGCATCCGGGTTGTCAGAAGGCCTTCAGTAACTCCAGTGACCGCGCCAAACACCAGCGGACGCATCTGGACAC
CAAACCTTATGCTTGTCAAATTCCAGGATGTACCAAACGCTACACAGACCCAAGTTCCCTAAGAAAGCATGTGAAGGCACATTCTTCCAA
AGAGCAACAAGCAAGGAAAAAGTTGCGGTCCAGCACAGAGCTCCATCCAGACCTGCTCACAGATTGCCTCACCGTGCAGTCCCTGCAGCC
GGCCACTTCCCCTAGAGATGCTGCTGCTGAAGGGACCGTGGGACGCTCCCCTGGACCCGGGCCTGACCTCTATTCAGCTCCCATTTTCTC
CAGCAATTATTCAAGCCGAAGTGGAACAGCTGCTGGGGCCGTACCACCCCCACATCCTGTCAGTCACCCTTCTCCAGGACATAATGTACA
GGGGAGCCCTCACAACCCCTCCTCCCAGTTACCTCCACTCACAGCTGTGGACGCAGGAGCTGAGAGGTTTGCACCTTCTGCTCCATCTCC
TCACCACATCAGCCCCCGGAGAGTTCCAGCTCCTTCTTCAATACTGCAAAGAACACAGCCTCCCTATACCCAGCAGCCATCAGGTTCACA
CCTGAAGTCCTATCAGCCAGAAACAAACTCTTCTTTTCAACCAAATGGTATCCATGTCCATGGATTTTATGGGCAGCTGCAGAAGTTCTG
TCCCCCACACTACCCCGATTCCCAGAGAATTGTGCCGCCTGTCAGCTCCTGCAGTGTGGTGCCTTCGTTTGAGGACTGCCTAGTCCCTAC
ATCCATGGGCCAGGCCAGTTTTGATGTTTTCCACAGAGCCTTCTCGACTCACTCGGGCATTACAGTGTATGATTTACCTTCAAGTTCCTC
GAGCCTCTTTGGGGAGTCTCTCCGCAGCGGGGCTGAAGATGCTACCTTCTTGCAGATCAGCACCGTGGACCGCTGTCCTAGCCAGCTCTC
CTCTGTCTACACCGAAGGCTAAAAGCTCTCTTGGCCACTCCTGCACACCCAGGACCTTGATGTTGCTTGCCACCTTTTGTTTTCGTACTC
TCACAGACTGCTTGAGGAAGGATGTCAGCCCAATCAGCGGGCCCTGCAGAGTTACTGATGTTCTTTCAGAAGGCAGGACTGAATGGCAGA
GCTAGCTTTGCAGGAATCATTACAGTTGCTCCTTTTTCTCTCTGGTTTTCCTGGACTATGTGACCAGGAGGACTGTCTTTTCAAAGGGAA
TTTAGAGCCTCACTCTCCTGGATACCTGTTACTTCCTGGCTGTCAACCCTTAAAGGACCCCAGTGAAATGATGTGCATATGAAAATGTAG
TTTGGGGATGACTCTACCTGAAAACTCCAAACAGGGAAAAAGACCTCAATTACGAGAGGCATAGTGACCTGCCTCACCTAATCCTCACCC
TTGCTGCTCCTGATGCAAAGCCAGGCACAACAAGGGAAATCCATGTCCAAAGCATAGTGTGGTCTCAACTCTTAGAAACTCCCTGGGTTT
CCCTTTTCTCTTAGCCACATGCTAACCAGTTGCTTCTCAGTGTTTCTCTTCAATAGAAAAATAAGGTTTTATATGCCAGCAGCCTATCCT
TGTTTTTGCATTTTAAAGACTTAGTTATTTATACGTATTTTAAAATGAAAAAAAAATGTAAAGGTCTGTGCTTTGGATGGAAATCATTAT
TATTGTAATCACCCCAGCTATAGACATTTTGCACAGCTGTGGTTCTGCCTGGCCCCACCTCTAGCATGTTAGTTTTGCAGTTAGCAAAGG
TTACCTGAGGGAAATGGAGTGGGCACCTCCCGCACCAACAGTCCTGTAGCTGGAACCTTCCTGAGTTGACTGTTTAGTAACTCCACCTCA
AAGACTGTGTTCAAAGAAAAATGTTGTTTGACTGGTTTACCCATTGCCTCCACTCTGGTGCTGCACCCAGAGAAGTGCCAGATGTGAGAA
CTGGGACAGACTGAGTCATGTGCCAGCTTCCCTTGGAAAACCAAACCTAGTGATACTTGACTTCCAGTGCTCAGATTTTACTAACGTTTT
TCAGGATATCCACTCATCTGTCTGTCTCTTCCCTACACTTCTCTCCACCCTCTTTTTGCATCCCTCTTACCCTCTTCCTGACTGTGGTTC
ATATATCCCCACCAGCCGCCATTGTCTGATCATCTTGGGAAGGTAGAGGTGACAGTTCTCGAAAAGTCTACAGAAAGAGGCAATTCTTTT
TCTGAGTTCCAGTTTGAAGGCCTGGAATTTTCACATAGCACTTGGTCGAAAATATCAAGCCTAAATAGGAAGTCATTTTCTGTGACACCT
CTACATAGCTATTACAGATCCTAAGTCCTAGGGCATCAGCTATAAAAATTGGCCAGTCCCAAAGACACAGTAAGTTCTAACATTCTGGTA
CTATCATATTTCAAGTATTTTTTCTCACTTTTTAAAAATGTTTTTCTGAACAAAAGTGAAACAATGCCATTTATCAAACTGAGATCATTA
CAATCTTCAACAAGACAACTAAAACAGCTTGATGTTAGATGGGATTCTGTGACAGTTTGTATACTGACAGGTCCTTCCAGTCTCCCTCCA
CAGTCCCACAAGCGGAAGTATTCTACCTGATTCCAGAGTTCATTCCAACATGCAGTAGAATGAGGTGAATGAAGAACCAAGTGTGGGTTT
TGTTTTCACAGTGCACTTGGTCAATCTAGTTTCTCTGAGTAGTGGGCTGTATTCTAAGAAAAGCTTTCACGTAGACGTCAAAGTCTGCAA
AAGAGATGAGTTAGCCACTTTAAAAAACCTGCTCTGCTTTACAAAAGATGCACACCAGGCTTCCTTTACAAGTGAACTCCAAGGCTGCTT
GTAAAGTACCACCCTTCCTGCAGACTTTGTGGGTCGTGTCACTTGGCCTAAACAAGTGGCCTAACATATGCATGCTCACAGCTAGTAGCA
TCCCTCATGCGTCCTTTGTCATACTCTGGAAAGAAAAAAACTCTGCTATCTTCAGAGAAACCATCTATTCATACTTAAATATGGAAGCCT
TTACAAGGAACTCAAAATACATTTCATTTCATTTGTACAATGAGAAAAAAGATGAAAAGGCAAGGTTGTTATTGCAGTTGACATTGTCAG
CCCTGCCTTTTGGCTTTATGTAATTTAAAATAGAAAGGGGGAAGGAGGACAAGACAGAAGCTCAACTTTAGAAACCATGGACATCACCTC
CCTCTTTGAGAGGAGCTGCTTGTGAACCAGGCTCCAGTCTTCCTGTGGCCTCTCACAGTAACCCTGCCCCTTTCTTACCTCACAGGGGCA
AGAGGGACTCTAAAGAGGGCGTAAGCAATAGAGGCACCTGCAGCCCTCCTTCCTCAGCAGGAAATCAATGTGGAGCCCCAGAGGGACATT
TTATCTCAGAGAGAGCATGCTGGCCACAGGACCCAGTGCAGCCCTGCTTCCCGCACCGTGGGTCTTTCCTGATAGCTGCAGGCTTGAGAT
TGCAGCCTCAGGATAGGACACGTTCAGATGCCTTCCAGACTACACACACTATGCTTAGATTCGAGAGTCTTTCCTGACCTTAAAATTTGT
CCCTTGCTTACTTTCACACTGCAGAAGATTTATATATATATTCATCATTATTTTTGCAGCAGTACAAGTGGAAACTTCAAAAAAATCATT
CCCTTTCATGTCCTGGTCTTTTTAAGTCTTGATATGTAACCATTTTCATAAATGTCCAAACAGAGATTGTCATTCCCCTTAAAAACAGAA
ACAAAACACAAAACTAGTGCTTGTGAAAACACACAGCGCAAAGACAATTATCCTATTGCATTAAAAAAAAAATCAGTCTGCCTAGAGACA
TTTCATTGGCTGCATTGTCTTAATTCCCTAACGAAACTGCATCAAAATGTCAGTTGTAATTTAGCCTCTGATCAGCTGTTAAATATTATT
TAAATATTTACAGGTCCTGTGGGGTATCTCCCATTACCCATGTCGCCCTCAAATTACATAAGCGATCATAAAATAAGAAGAAAAAAAAAG
GTCTTTAGTAGATCACAGCAGAGTTACCACTGATAAGAGTGTTGGCTTTGTTCAGTTGTTTCTAAATTACCAGCCGTCAAGCACAGTAGC
CCCTAAAACCAATTTTGAGCAAGGATAAATTCAACTCCCTCATCTGAGAACCTTGACTTTCCAGTTGCCTTGAAGTATTGGGAATAGTAA
CTGTACATTTTCAATTTAATTATTTGGTATTTTATTTGACTGTCTTGGCCATGTCATTTTATGGAAGCATTTTTAAATAGCACTTTTTGT
TAGTGGTGTGGAATTTCTGCGGTTATTATTTTTTTTTTTTTTTGCAACAGATGAAGCAAAAAAAAAAAAGCACTCATTGGAGAAATAGTG
AGTGTAAAAAGAGATTTATTTTGTACAGACAGCAAAGTATCCTGTGTAATGTTGCTGACATAAAGCACTTTGGGGGAAAAAAGTGGAAAT
CTGTTTTCCATAAATCACACAGACTCTTGTACATAGTTATATACACTCACGTAGAGAAATGAACTGCATATATCATACTGGATATGGGGC
CGATTTTACTCTAGAGGCACATCTGGTGCTTATTGTCATAAATCTTTTAAAGAATTAGGTACACTTTTTTCTATTAATATGTATAGTTTT
GTGATTTGTCACAGTTATGTTTCATATAATCATAAGTTATTTTGTCTTGTTCATGAAGTCCTTTTTTTATGTCAAAAGTAAAATGAAGGG
ATTGTGCACTTGGTACAGAATAAAACTGGAAATAGAGAAGACGCCCTCCTGCCTAAAATCCTCCTTCAGCCTGTCGGTTTAAAACACAAT
GGCAACCATCATTGTTTGTTTGTTTGTTTTTTTGTTTTGTTTTACCATCAGCCTCTTACATACTGGGAATGGTAATTATAATTAAAGGCA
GATGATGCGGGAGGGAATGTTCAAGTCCAGCTTTAAAATGCTGCATTGCTTTGGGCCAGAGCTGTAGCCTGGATTTAATTATAGATATGA
GGAGGAAATGGCAGTAAAAATGAATGTCTCCCTGAGTCCTTTACATGTTGGGAGTGTCCATAAATAAAACATGAAGTTTTATTTCATCAG

>55234_55234_1_MRRF-GLIS3_MRRF_chr9_125075665_ENST00000297908_GLIS3_chr9_3937189_ENST00000324333_length(amino acids)=572AA_BP=211
MRSPPSHESFLSNLGDSCGCFQGLSSVMALGLKCFRMVHPTFRNYLAASIRPVSEVTLKTVHERQHGHRQYMAYSAVPVRHFATKKAKGS
LDKIAVVTADGKLALNQISQISMKSPQLILVNMASFPECTAAAIKAIRESGMNLNPEVEGTLIRVPIPQVTREHREMLVKLAKQNTNKAK
DSLRKVRTNSMNKLKKSKDTVSEDTIRLIEKQFEGCEKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYA
CQIPGCTKRYTDPSSLRKHVKAHSSKEQQARKKLRSSTELHPDLLTDCLTVQSLQPATSPRDAAAEGTVGRSPGPGPDLYSAPIFSSNYS
SRSGTAAGAVPPPHPVSHPSPGHNVQGSPHNPSSQLPPLTAVDAGAERFAPSAPSPHHISPRRVPAPSSILQRTQPPYTQQPSGSHLKSY
QPETNSSFQPNGIHVHGFYGQLQKFCPPHYPDSQRIVPPVSSCSVVPSFEDCLVPTSMGQASFDVFHRAFSTHSGITVYDLPSSSSSLFG

--------------------------------------------------------------
>55234_55234_2_MRRF-GLIS3_MRRF_chr9_125075665_ENST00000297908_GLIS3_chr9_3937189_ENST00000381971_length(transcript)=2576nt_BP=919nt
ACAGGACAATCCGGGGCGGGGCCTGAGATGCAGTCCTGCGAGGGCGGCCTCCTGTAAGACCTCTTAGCGGGCCCATCGCTGAGGTGCAGG
GACATGTCGCGGCCGAACTCACCTCGTGGCCTCGGCGTGGTGCTCTCAGCTCATGCCCGGAAACCAGGTCCCGACGCCGCGGTCAGACGG
ACCTCTAGACGCGTCCGCCTCAATGCCGCCAGCTGCCAGGCCGCCCGTGACGCGTTAAGCCTGCGCCGCCTCCTGGCTTCGTGACGTCAC
GACGTCCGCGCAGCTGCGGTCGCCGCCGTCGCACGAGTCTTTCCTTAGTAACCTGGGCGATAGCTGTGGATGTTTCCAAGGATTGTCTTC
AGTCATGGCCTTGGGATTAAAGTGCTTCCGCATGGTCCACCCTACCTTTCGCAATTATCTTGCAGCCTCTATCAGACCCGTTTCAGAAGT
TACACTGAAGACAGTGCATGAAAGACAACATGGCCATAGGCAATACATGGCCTATTCAGCTGTACCAGTCCGCCATTTTGCTACCAAGAA
AGCCAAAGGATCCCTTGACAAGATTGCTGTGGTAACTGCTGACGGGAAGCTTGCTTTAAACCAGATTAGCCAGATCTCCATGAAGTCGCC
ACAGCTGATTTTGGTGAATATGGCCAGCTTCCCAGAGTGTACAGCTGCAGCTATCAAGGCTATAAGAGAAAGTGGAATGAATCTGAACCC
AGAAGTGGAAGGGACGCTAATTCGGGTACCCATTCCCCAAGTAACCAGAGAGCACAGAGAAATGCTGGTGAAACTGGCCAAACAGAACAC
CAACAAGGCCAAAGACTCTTTACGGAAGGTTCGCACCAACTCAATGAACAAGCTGAAGAAATCCAAGGATACAGTCTCAGAGGACACCAT
TAGGCTAATAGAGAAACAGTTTGAAGGTTGCGAGAAGGCCTTTTCAAGGCTTGAAAATCTCAAGATCCACTTGCGGAGCCACACAGGCGA
GAAGCCGTATTTGTGCCAGCATCCGGGTTGTCAGAAGGCCTTCAGTAACTCCAGTGACCGCGCCAAACACCAGCGGACGCATCTGGACAC
CAAACCTTATGCTTGTCAAATTCCAGGATGTACCAAACGCTACACAGACCCAAGTTCCCTAAGAAAGCATGTGAAGGCACATTCTTCCAA
AGAGCAACAAGCAAGGAAAAAGTTGCGGTCCAGCACAGAGCTCCATCCAGACCTGCTCACAGATTGCCTCACCGTGCAGTCCCTGCAGCC
GGCCACTTCCCCTAGAGATGCTGCTGCTGAAGGGACCGTGGGACGCTCCCCTGGACCCGGGCCTGACCTCTATTCAGCTCCCATTTTCTC
CAGCAATTATTCAAGCCGAAGTGGAACAGCTGCTGGGGCCGTACCACCCCCACATCCTGTCAGTCACCCTTCTCCAGGACATAATGTACA
GGGGAGCCCTCACAACCCCTCCTCCCAGTTACCTCCACTCACAGCTGTGGACGCAGGAGCTGAGAGGTTTGCACCTTCTGCTCCATCTCC
TCACCACATCAGCCCCCGGAGAGTTCCAGCTCCTTCTTCAATACTGCAAAGAACACAGCCTCCCTATACCCAGCAGCCATCAGGTTCACA
CCTGAAGTCCTATCAGCCAGAAACAAACTCTTCTTTTCAACCAAATGGTATCCATGTCCATGGATTTTATGGGCAGCTGCAGAAGTTCTG
TCCCCCACACTACCCCGATTCCCAGAGAATTGTGCCGCCTGTCAGCTCCTGCAGTGTGGTGCCTTCGTTTGAGGACTGCCTAGTCCCTAC
ATCCATGGGCCAGGCCAGTTTTGATGTTTTCCACAGAGCCTTCTCGACTCACTCGGGCATTACAGTGTATGATTTACCTTCAAGTTCCTC
GAGCCTCTTTGGGGAGTCTCTCCGCAGCGGGGCTGAAGATGCTACCTTCTTGCAGATCAGCACCGTGGACCGCTGTCCTAGCCAGCTCTC
CTCTGTCTACACCGAAGGCTAAAAGCTCTCTTGGCCACTCCTGCACACCCAGGACCTTGATGTTGCTTGCCACCTTTTGTTTTCGTACTC
TCACAGACTGCTTGAGGAAGGATGTCAGCCCAATCAGCGGGCCCTGCAGAGTTACTGATGTTCTTTCAGAAGGCAGGACTGAATGGCAGA
GCTAGCTTTGCAGGAATCATTACAGTTGCTCCTTTTTCTCTCTGGTTTTCCTGGACTATGTGACCAGGAGGACTGTCTTTTCAAAGGGAA
TTTAGAGCCTCACTCTCCTGGATACCTGTTACTTCCTGGCTGTCAACCCTTAAAGGACCCCAGTGAAATGATGTGCATATGAAAATGTAG
TTTGGGGATGACTCTACCTGAAAACTCCAAACAGGGAAAAAGACCTCAATTACGAGAGGCATAGTGACCTGCCTCACCTAATCCTCACCC
TTGCTGCTCCTGATGCAAAGCCAGGCACAACAAGGGAAATCCATGTCCAAAGCATAGTGTGGTCTCAACTCTTAGAAACTCCCTGGGTTT

>55234_55234_2_MRRF-GLIS3_MRRF_chr9_125075665_ENST00000297908_GLIS3_chr9_3937189_ENST00000381971_length(amino acids)=572AA_BP=211
MRSPPSHESFLSNLGDSCGCFQGLSSVMALGLKCFRMVHPTFRNYLAASIRPVSEVTLKTVHERQHGHRQYMAYSAVPVRHFATKKAKGS
LDKIAVVTADGKLALNQISQISMKSPQLILVNMASFPECTAAAIKAIRESGMNLNPEVEGTLIRVPIPQVTREHREMLVKLAKQNTNKAK
DSLRKVRTNSMNKLKKSKDTVSEDTIRLIEKQFEGCEKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYA
CQIPGCTKRYTDPSSLRKHVKAHSSKEQQARKKLRSSTELHPDLLTDCLTVQSLQPATSPRDAAAEGTVGRSPGPGPDLYSAPIFSSNYS
SRSGTAAGAVPPPHPVSHPSPGHNVQGSPHNPSSQLPPLTAVDAGAERFAPSAPSPHHISPRRVPAPSSILQRTQPPYTQQPSGSHLKSY
QPETNSSFQPNGIHVHGFYGQLQKFCPPHYPDSQRIVPPVSSCSVVPSFEDCLVPTSMGQASFDVFHRAFSTHSGITVYDLPSSSSSLFG

--------------------------------------------------------------
>55234_55234_3_MRRF-GLIS3_MRRF_chr9_125075665_ENST00000344641_GLIS3_chr9_3937189_ENST00000324333_length(transcript)=6250nt_BP=1022nt
GTAAGACCTCTTAGCGGGCCCATCGCTGAGGTGCAGGGACATGTCGCGGCCGAACTCACCTCGTGGCCTCGGCGTGGTGCTCTCAGCTCA
TGCCCGGAAACCAGGTCCCGACGCCGCGGTCAGACGGACCTCTAGACGCGTCCGCCTCAATGCCGCCAGCTGCCAGGCCGCCCGTGACGC
GTTAAGCCTGCGCCGCCTCCTGGCTTCGTGACGTCACGACGTCCGCGCAGCTGCGGTCGCCGCCGTCGCACGAGTCTTTCCTTAGTAACC
TGGGCGATAGCTGTGGATGTTTCCAAGGATTGTCTTCAGTCATGGCCTTGGGATTAAAGTGCTTCCGCATGGTCCACCCTACCTTTCGCA
ATTATCTTGCAGCCTCTATCAGACCCGTTTCAGAAGTTACACTGAAGACAGTGCATGAAAGACAACATGGCCATAGGCAATACATGGCCT
ATTCAGCTGTACCAGTCCGCCATTTTGCTACCAAGAAAGCCAAAGCCAAAGGGAAAGGACAGTCCCAAACCAGAGTGAATATTAATGCTG
CCTTGGTTGAGGATATAATCAACTTGGAAGAGGTGAATGAAGAAATGAAGTCTGTGATAGAAGCTCTCAAGGATAATTTCAATAAGACTC
TCAATATAAGGACCTCACCAGGATCCCTTGACAAGATTGCTGTGGTAACTGCTGACGGGAAGCTTGCTTTAAACCAGATTAGCCAGATCT
CCATGAAGTCGCCACAGCTGATTTTGGTGAATATGGCCAGCTTCCCAGAGTGTACAGCTGCAGCTATCAAGGCTATAAGAGAAAGTGGAA
TGAATCTGAACCCAGAAGTGGAAGGGACGCTAATTCGGGTACCCATTCCCCAAGTAACCAGAGAGCACAGAGAAATGCTGGTGAAACTGG
CCAAACAGAACACCAACAAGGCCAAAGACTCTTTACGGAAGGTTCGCACCAACTCAATGAACAAGCTGAAGAAATCCAAGGATACAGTCT
CAGAGGACACCATTAGGCTAATAGAGAAACAGTTTGAAGGTTGCGAGAAGGCCTTTTCAAGGCTTGAAAATCTCAAGATCCACTTGCGGA
GCCACACAGGCGAGAAGCCGTATTTGTGCCAGCATCCGGGTTGTCAGAAGGCCTTCAGTAACTCCAGTGACCGCGCCAAACACCAGCGGA
CGCATCTGGACACCAAACCTTATGCTTGTCAAATTCCAGGATGTACCAAACGCTACACAGACCCAAGTTCCCTAAGAAAGCATGTGAAGG
CACATTCTTCCAAAGAGCAACAAGCAAGGAAAAAGTTGCGGTCCAGCACAGAGCTCCATCCAGACCTGCTCACAGATTGCCTCACCGTGC
AGTCCCTGCAGCCGGCCACTTCCCCTAGAGATGCTGCTGCTGAAGGGACCGTGGGACGCTCCCCTGGACCCGGGCCTGACCTCTATTCAG
CTCCCATTTTCTCCAGCAATTATTCAAGCCGAAGTGGAACAGCTGCTGGGGCCGTACCACCCCCACATCCTGTCAGTCACCCTTCTCCAG
GACATAATGTACAGGGGAGCCCTCACAACCCCTCCTCCCAGTTACCTCCACTCACAGCTGTGGACGCAGGAGCTGAGAGGTTTGCACCTT
CTGCTCCATCTCCTCACCACATCAGCCCCCGGAGAGTTCCAGCTCCTTCTTCAATACTGCAAAGAACACAGCCTCCCTATACCCAGCAGC
CATCAGGTTCACACCTGAAGTCCTATCAGCCAGAAACAAACTCTTCTTTTCAACCAAATGGTATCCATGTCCATGGATTTTATGGGCAGC
TGCAGAAGTTCTGTCCCCCACACTACCCCGATTCCCAGAGAATTGTGCCGCCTGTCAGCTCCTGCAGTGTGGTGCCTTCGTTTGAGGACT
GCCTAGTCCCTACATCCATGGGCCAGGCCAGTTTTGATGTTTTCCACAGAGCCTTCTCGACTCACTCGGGCATTACAGTGTATGATTTAC
CTTCAAGTTCCTCGAGCCTCTTTGGGGAGTCTCTCCGCAGCGGGGCTGAAGATGCTACCTTCTTGCAGATCAGCACCGTGGACCGCTGTC
CTAGCCAGCTCTCCTCTGTCTACACCGAAGGCTAAAAGCTCTCTTGGCCACTCCTGCACACCCAGGACCTTGATGTTGCTTGCCACCTTT
TGTTTTCGTACTCTCACAGACTGCTTGAGGAAGGATGTCAGCCCAATCAGCGGGCCCTGCAGAGTTACTGATGTTCTTTCAGAAGGCAGG
ACTGAATGGCAGAGCTAGCTTTGCAGGAATCATTACAGTTGCTCCTTTTTCTCTCTGGTTTTCCTGGACTATGTGACCAGGAGGACTGTC
TTTTCAAAGGGAATTTAGAGCCTCACTCTCCTGGATACCTGTTACTTCCTGGCTGTCAACCCTTAAAGGACCCCAGTGAAATGATGTGCA
TATGAAAATGTAGTTTGGGGATGACTCTACCTGAAAACTCCAAACAGGGAAAAAGACCTCAATTACGAGAGGCATAGTGACCTGCCTCAC
CTAATCCTCACCCTTGCTGCTCCTGATGCAAAGCCAGGCACAACAAGGGAAATCCATGTCCAAAGCATAGTGTGGTCTCAACTCTTAGAA
ACTCCCTGGGTTTCCCTTTTCTCTTAGCCACATGCTAACCAGTTGCTTCTCAGTGTTTCTCTTCAATAGAAAAATAAGGTTTTATATGCC
AGCAGCCTATCCTTGTTTTTGCATTTTAAAGACTTAGTTATTTATACGTATTTTAAAATGAAAAAAAAATGTAAAGGTCTGTGCTTTGGA
TGGAAATCATTATTATTGTAATCACCCCAGCTATAGACATTTTGCACAGCTGTGGTTCTGCCTGGCCCCACCTCTAGCATGTTAGTTTTG
CAGTTAGCAAAGGTTACCTGAGGGAAATGGAGTGGGCACCTCCCGCACCAACAGTCCTGTAGCTGGAACCTTCCTGAGTTGACTGTTTAG
TAACTCCACCTCAAAGACTGTGTTCAAAGAAAAATGTTGTTTGACTGGTTTACCCATTGCCTCCACTCTGGTGCTGCACCCAGAGAAGTG
CCAGATGTGAGAACTGGGACAGACTGAGTCATGTGCCAGCTTCCCTTGGAAAACCAAACCTAGTGATACTTGACTTCCAGTGCTCAGATT
TTACTAACGTTTTTCAGGATATCCACTCATCTGTCTGTCTCTTCCCTACACTTCTCTCCACCCTCTTTTTGCATCCCTCTTACCCTCTTC
CTGACTGTGGTTCATATATCCCCACCAGCCGCCATTGTCTGATCATCTTGGGAAGGTAGAGGTGACAGTTCTCGAAAAGTCTACAGAAAG
AGGCAATTCTTTTTCTGAGTTCCAGTTTGAAGGCCTGGAATTTTCACATAGCACTTGGTCGAAAATATCAAGCCTAAATAGGAAGTCATT
TTCTGTGACACCTCTACATAGCTATTACAGATCCTAAGTCCTAGGGCATCAGCTATAAAAATTGGCCAGTCCCAAAGACACAGTAAGTTC
TAACATTCTGGTACTATCATATTTCAAGTATTTTTTCTCACTTTTTAAAAATGTTTTTCTGAACAAAAGTGAAACAATGCCATTTATCAA
ACTGAGATCATTACAATCTTCAACAAGACAACTAAAACAGCTTGATGTTAGATGGGATTCTGTGACAGTTTGTATACTGACAGGTCCTTC
CAGTCTCCCTCCACAGTCCCACAAGCGGAAGTATTCTACCTGATTCCAGAGTTCATTCCAACATGCAGTAGAATGAGGTGAATGAAGAAC
CAAGTGTGGGTTTTGTTTTCACAGTGCACTTGGTCAATCTAGTTTCTCTGAGTAGTGGGCTGTATTCTAAGAAAAGCTTTCACGTAGACG
TCAAAGTCTGCAAAAGAGATGAGTTAGCCACTTTAAAAAACCTGCTCTGCTTTACAAAAGATGCACACCAGGCTTCCTTTACAAGTGAAC
TCCAAGGCTGCTTGTAAAGTACCACCCTTCCTGCAGACTTTGTGGGTCGTGTCACTTGGCCTAAACAAGTGGCCTAACATATGCATGCTC
ACAGCTAGTAGCATCCCTCATGCGTCCTTTGTCATACTCTGGAAAGAAAAAAACTCTGCTATCTTCAGAGAAACCATCTATTCATACTTA
AATATGGAAGCCTTTACAAGGAACTCAAAATACATTTCATTTCATTTGTACAATGAGAAAAAAGATGAAAAGGCAAGGTTGTTATTGCAG
TTGACATTGTCAGCCCTGCCTTTTGGCTTTATGTAATTTAAAATAGAAAGGGGGAAGGAGGACAAGACAGAAGCTCAACTTTAGAAACCA
TGGACATCACCTCCCTCTTTGAGAGGAGCTGCTTGTGAACCAGGCTCCAGTCTTCCTGTGGCCTCTCACAGTAACCCTGCCCCTTTCTTA
CCTCACAGGGGCAAGAGGGACTCTAAAGAGGGCGTAAGCAATAGAGGCACCTGCAGCCCTCCTTCCTCAGCAGGAAATCAATGTGGAGCC
CCAGAGGGACATTTTATCTCAGAGAGAGCATGCTGGCCACAGGACCCAGTGCAGCCCTGCTTCCCGCACCGTGGGTCTTTCCTGATAGCT
GCAGGCTTGAGATTGCAGCCTCAGGATAGGACACGTTCAGATGCCTTCCAGACTACACACACTATGCTTAGATTCGAGAGTCTTTCCTGA
CCTTAAAATTTGTCCCTTGCTTACTTTCACACTGCAGAAGATTTATATATATATTCATCATTATTTTTGCAGCAGTACAAGTGGAAACTT
CAAAAAAATCATTCCCTTTCATGTCCTGGTCTTTTTAAGTCTTGATATGTAACCATTTTCATAAATGTCCAAACAGAGATTGTCATTCCC
CTTAAAAACAGAAACAAAACACAAAACTAGTGCTTGTGAAAACACACAGCGCAAAGACAATTATCCTATTGCATTAAAAAAAAAATCAGT
CTGCCTAGAGACATTTCATTGGCTGCATTGTCTTAATTCCCTAACGAAACTGCATCAAAATGTCAGTTGTAATTTAGCCTCTGATCAGCT
GTTAAATATTATTTAAATATTTACAGGTCCTGTGGGGTATCTCCCATTACCCATGTCGCCCTCAAATTACATAAGCGATCATAAAATAAG
AAGAAAAAAAAAGGTCTTTAGTAGATCACAGCAGAGTTACCACTGATAAGAGTGTTGGCTTTGTTCAGTTGTTTCTAAATTACCAGCCGT
CAAGCACAGTAGCCCCTAAAACCAATTTTGAGCAAGGATAAATTCAACTCCCTCATCTGAGAACCTTGACTTTCCAGTTGCCTTGAAGTA
TTGGGAATAGTAACTGTACATTTTCAATTTAATTATTTGGTATTTTATTTGACTGTCTTGGCCATGTCATTTTATGGAAGCATTTTTAAA
TAGCACTTTTTGTTAGTGGTGTGGAATTTCTGCGGTTATTATTTTTTTTTTTTTTTGCAACAGATGAAGCAAAAAAAAAAAAGCACTCAT
TGGAGAAATAGTGAGTGTAAAAAGAGATTTATTTTGTACAGACAGCAAAGTATCCTGTGTAATGTTGCTGACATAAAGCACTTTGGGGGA
AAAAAGTGGAAATCTGTTTTCCATAAATCACACAGACTCTTGTACATAGTTATATACACTCACGTAGAGAAATGAACTGCATATATCATA
CTGGATATGGGGCCGATTTTACTCTAGAGGCACATCTGGTGCTTATTGTCATAAATCTTTTAAAGAATTAGGTACACTTTTTTCTATTAA
TATGTATAGTTTTGTGATTTGTCACAGTTATGTTTCATATAATCATAAGTTATTTTGTCTTGTTCATGAAGTCCTTTTTTTATGTCAAAA
GTAAAATGAAGGGATTGTGCACTTGGTACAGAATAAAACTGGAAATAGAGAAGACGCCCTCCTGCCTAAAATCCTCCTTCAGCCTGTCGG
TTTAAAACACAATGGCAACCATCATTGTTTGTTTGTTTGTTTTTTTGTTTTGTTTTACCATCAGCCTCTTACATACTGGGAATGGTAATT
ATAATTAAAGGCAGATGATGCGGGAGGGAATGTTCAAGTCCAGCTTTAAAATGCTGCATTGCTTTGGGCCAGAGCTGTAGCCTGGATTTA
ATTATAGATATGAGGAGGAAATGGCAGTAAAAATGAATGTCTCCCTGAGTCCTTTACATGTTGGGAGTGTCCATAAATAAAACATGAAGT

>55234_55234_3_MRRF-GLIS3_MRRF_chr9_125075665_ENST00000344641_GLIS3_chr9_3937189_ENST00000324333_length(amino acids)=624AA_BP=263
MRSPPSHESFLSNLGDSCGCFQGLSSVMALGLKCFRMVHPTFRNYLAASIRPVSEVTLKTVHERQHGHRQYMAYSAVPVRHFATKKAKAK
GKGQSQTRVNINAALVEDIINLEEVNEEMKSVIEALKDNFNKTLNIRTSPGSLDKIAVVTADGKLALNQISQISMKSPQLILVNMASFPE
CTAAAIKAIRESGMNLNPEVEGTLIRVPIPQVTREHREMLVKLAKQNTNKAKDSLRKVRTNSMNKLKKSKDTVSEDTIRLIEKQFEGCEK
AFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCTKRYTDPSSLRKHVKAHSSKEQQARKKLRSST
ELHPDLLTDCLTVQSLQPATSPRDAAAEGTVGRSPGPGPDLYSAPIFSSNYSSRSGTAAGAVPPPHPVSHPSPGHNVQGSPHNPSSQLPP
LTAVDAGAERFAPSAPSPHHISPRRVPAPSSILQRTQPPYTQQPSGSHLKSYQPETNSSFQPNGIHVHGFYGQLQKFCPPHYPDSQRIVP

--------------------------------------------------------------
>55234_55234_4_MRRF-GLIS3_MRRF_chr9_125075665_ENST00000344641_GLIS3_chr9_3937189_ENST00000381971_length(transcript)=2679nt_BP=1022nt
GTAAGACCTCTTAGCGGGCCCATCGCTGAGGTGCAGGGACATGTCGCGGCCGAACTCACCTCGTGGCCTCGGCGTGGTGCTCTCAGCTCA
TGCCCGGAAACCAGGTCCCGACGCCGCGGTCAGACGGACCTCTAGACGCGTCCGCCTCAATGCCGCCAGCTGCCAGGCCGCCCGTGACGC
GTTAAGCCTGCGCCGCCTCCTGGCTTCGTGACGTCACGACGTCCGCGCAGCTGCGGTCGCCGCCGTCGCACGAGTCTTTCCTTAGTAACC
TGGGCGATAGCTGTGGATGTTTCCAAGGATTGTCTTCAGTCATGGCCTTGGGATTAAAGTGCTTCCGCATGGTCCACCCTACCTTTCGCA
ATTATCTTGCAGCCTCTATCAGACCCGTTTCAGAAGTTACACTGAAGACAGTGCATGAAAGACAACATGGCCATAGGCAATACATGGCCT
ATTCAGCTGTACCAGTCCGCCATTTTGCTACCAAGAAAGCCAAAGCCAAAGGGAAAGGACAGTCCCAAACCAGAGTGAATATTAATGCTG
CCTTGGTTGAGGATATAATCAACTTGGAAGAGGTGAATGAAGAAATGAAGTCTGTGATAGAAGCTCTCAAGGATAATTTCAATAAGACTC
TCAATATAAGGACCTCACCAGGATCCCTTGACAAGATTGCTGTGGTAACTGCTGACGGGAAGCTTGCTTTAAACCAGATTAGCCAGATCT
CCATGAAGTCGCCACAGCTGATTTTGGTGAATATGGCCAGCTTCCCAGAGTGTACAGCTGCAGCTATCAAGGCTATAAGAGAAAGTGGAA
TGAATCTGAACCCAGAAGTGGAAGGGACGCTAATTCGGGTACCCATTCCCCAAGTAACCAGAGAGCACAGAGAAATGCTGGTGAAACTGG
CCAAACAGAACACCAACAAGGCCAAAGACTCTTTACGGAAGGTTCGCACCAACTCAATGAACAAGCTGAAGAAATCCAAGGATACAGTCT
CAGAGGACACCATTAGGCTAATAGAGAAACAGTTTGAAGGTTGCGAGAAGGCCTTTTCAAGGCTTGAAAATCTCAAGATCCACTTGCGGA
GCCACACAGGCGAGAAGCCGTATTTGTGCCAGCATCCGGGTTGTCAGAAGGCCTTCAGTAACTCCAGTGACCGCGCCAAACACCAGCGGA
CGCATCTGGACACCAAACCTTATGCTTGTCAAATTCCAGGATGTACCAAACGCTACACAGACCCAAGTTCCCTAAGAAAGCATGTGAAGG
CACATTCTTCCAAAGAGCAACAAGCAAGGAAAAAGTTGCGGTCCAGCACAGAGCTCCATCCAGACCTGCTCACAGATTGCCTCACCGTGC
AGTCCCTGCAGCCGGCCACTTCCCCTAGAGATGCTGCTGCTGAAGGGACCGTGGGACGCTCCCCTGGACCCGGGCCTGACCTCTATTCAG
CTCCCATTTTCTCCAGCAATTATTCAAGCCGAAGTGGAACAGCTGCTGGGGCCGTACCACCCCCACATCCTGTCAGTCACCCTTCTCCAG
GACATAATGTACAGGGGAGCCCTCACAACCCCTCCTCCCAGTTACCTCCACTCACAGCTGTGGACGCAGGAGCTGAGAGGTTTGCACCTT
CTGCTCCATCTCCTCACCACATCAGCCCCCGGAGAGTTCCAGCTCCTTCTTCAATACTGCAAAGAACACAGCCTCCCTATACCCAGCAGC
CATCAGGTTCACACCTGAAGTCCTATCAGCCAGAAACAAACTCTTCTTTTCAACCAAATGGTATCCATGTCCATGGATTTTATGGGCAGC
TGCAGAAGTTCTGTCCCCCACACTACCCCGATTCCCAGAGAATTGTGCCGCCTGTCAGCTCCTGCAGTGTGGTGCCTTCGTTTGAGGACT
GCCTAGTCCCTACATCCATGGGCCAGGCCAGTTTTGATGTTTTCCACAGAGCCTTCTCGACTCACTCGGGCATTACAGTGTATGATTTAC
CTTCAAGTTCCTCGAGCCTCTTTGGGGAGTCTCTCCGCAGCGGGGCTGAAGATGCTACCTTCTTGCAGATCAGCACCGTGGACCGCTGTC
CTAGCCAGCTCTCCTCTGTCTACACCGAAGGCTAAAAGCTCTCTTGGCCACTCCTGCACACCCAGGACCTTGATGTTGCTTGCCACCTTT
TGTTTTCGTACTCTCACAGACTGCTTGAGGAAGGATGTCAGCCCAATCAGCGGGCCCTGCAGAGTTACTGATGTTCTTTCAGAAGGCAGG
ACTGAATGGCAGAGCTAGCTTTGCAGGAATCATTACAGTTGCTCCTTTTTCTCTCTGGTTTTCCTGGACTATGTGACCAGGAGGACTGTC
TTTTCAAAGGGAATTTAGAGCCTCACTCTCCTGGATACCTGTTACTTCCTGGCTGTCAACCCTTAAAGGACCCCAGTGAAATGATGTGCA
TATGAAAATGTAGTTTGGGGATGACTCTACCTGAAAACTCCAAACAGGGAAAAAGACCTCAATTACGAGAGGCATAGTGACCTGCCTCAC
CTAATCCTCACCCTTGCTGCTCCTGATGCAAAGCCAGGCACAACAAGGGAAATCCATGTCCAAAGCATAGTGTGGTCTCAACTCTTAGAA

>55234_55234_4_MRRF-GLIS3_MRRF_chr9_125075665_ENST00000344641_GLIS3_chr9_3937189_ENST00000381971_length(amino acids)=624AA_BP=263
MRSPPSHESFLSNLGDSCGCFQGLSSVMALGLKCFRMVHPTFRNYLAASIRPVSEVTLKTVHERQHGHRQYMAYSAVPVRHFATKKAKAK
GKGQSQTRVNINAALVEDIINLEEVNEEMKSVIEALKDNFNKTLNIRTSPGSLDKIAVVTADGKLALNQISQISMKSPQLILVNMASFPE
CTAAAIKAIRESGMNLNPEVEGTLIRVPIPQVTREHREMLVKLAKQNTNKAKDSLRKVRTNSMNKLKKSKDTVSEDTIRLIEKQFEGCEK
AFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCTKRYTDPSSLRKHVKAHSSKEQQARKKLRSST
ELHPDLLTDCLTVQSLQPATSPRDAAAEGTVGRSPGPGPDLYSAPIFSSNYSSRSGTAAGAVPPPHPVSHPSPGHNVQGSPHNPSSQLPP
LTAVDAGAERFAPSAPSPHHISPRRVPAPSSILQRTQPPYTQQPSGSHLKSYQPETNSSFQPNGIHVHGFYGQLQKFCPPHYPDSQRIVP

--------------------------------------------------------------
>55234_55234_5_MRRF-GLIS3_MRRF_chr9_125075665_ENST00000373729_GLIS3_chr9_3937189_ENST00000324333_length(transcript)=5913nt_BP=685nt
CACGAGTCTTTCCTTAGTAACCTGGGCGATAGCTGCCTCTATCAGACCCGTTTCAGAAGTTACACTGAAGACAGTGCATGAAAGACAACA
TGGCCATAGGCAATACATGGCCTATTCAGCTGTACCAGTCCGCCATTTTGCTACCAAGAAAGCCAAAGCCAAAGGGAAAGGACAGTCCCA
AACCAGAGTGAATATTAATGCTGCCTTGGTTGAGGATATAATCAACTTGGAAGAGGTGAATGAAGAAATGAAGTCTGTGATAGAAGCTCT
CAAGGATAATTTCAATAAGACTCTCAATATAAGGACCTCACCAGGATCCCTTGACAAGATTGCTGTGGTAACTGCTGACGGGAAGCTTGC
TTTAAACCAGATTAGCCAGATCTCCATGAAGTCGCCACAGCTGATTTTGGTGAATATGGCCAGCTTCCCAGAGTGTACAGCTGCAGCTAT
CAAGGCTATAAGAGAAAGTGGAATGAATCTGAACCCAGAAGTGGAAGGGACGCTAATTCGGGTACCCATTCCCCAAGTAACCAGAGAGCA
CAGAGAAATGCTGGTGAAACTGGCCAAACAGAACACCAACAAGGCCAAAGACTCTTTACGGAAGGTTCGCACCAACTCAATGAACAAGCT
GAAGAAATCCAAGGATACAGTCTCAGAGGACACCATTAGGCTAATAGAGAAACAGTTTGAAGGTTGCGAGAAGGCCTTTTCAAGGCTTGA
AAATCTCAAGATCCACTTGCGGAGCCACACAGGCGAGAAGCCGTATTTGTGCCAGCATCCGGGTTGTCAGAAGGCCTTCAGTAACTCCAG
TGACCGCGCCAAACACCAGCGGACGCATCTGGACACCAAACCTTATGCTTGTCAAATTCCAGGATGTACCAAACGCTACACAGACCCAAG
TTCCCTAAGAAAGCATGTGAAGGCACATTCTTCCAAAGAGCAACAAGCAAGGAAAAAGTTGCGGTCCAGCACAGAGCTCCATCCAGACCT
GCTCACAGATTGCCTCACCGTGCAGTCCCTGCAGCCGGCCACTTCCCCTAGAGATGCTGCTGCTGAAGGGACCGTGGGACGCTCCCCTGG
ACCCGGGCCTGACCTCTATTCAGCTCCCATTTTCTCCAGCAATTATTCAAGCCGAAGTGGAACAGCTGCTGGGGCCGTACCACCCCCACA
TCCTGTCAGTCACCCTTCTCCAGGACATAATGTACAGGGGAGCCCTCACAACCCCTCCTCCCAGTTACCTCCACTCACAGCTGTGGACGC
AGGAGCTGAGAGGTTTGCACCTTCTGCTCCATCTCCTCACCACATCAGCCCCCGGAGAGTTCCAGCTCCTTCTTCAATACTGCAAAGAAC
ACAGCCTCCCTATACCCAGCAGCCATCAGGTTCACACCTGAAGTCCTATCAGCCAGAAACAAACTCTTCTTTTCAACCAAATGGTATCCA
TGTCCATGGATTTTATGGGCAGCTGCAGAAGTTCTGTCCCCCACACTACCCCGATTCCCAGAGAATTGTGCCGCCTGTCAGCTCCTGCAG
TGTGGTGCCTTCGTTTGAGGACTGCCTAGTCCCTACATCCATGGGCCAGGCCAGTTTTGATGTTTTCCACAGAGCCTTCTCGACTCACTC
GGGCATTACAGTGTATGATTTACCTTCAAGTTCCTCGAGCCTCTTTGGGGAGTCTCTCCGCAGCGGGGCTGAAGATGCTACCTTCTTGCA
GATCAGCACCGTGGACCGCTGTCCTAGCCAGCTCTCCTCTGTCTACACCGAAGGCTAAAAGCTCTCTTGGCCACTCCTGCACACCCAGGA
CCTTGATGTTGCTTGCCACCTTTTGTTTTCGTACTCTCACAGACTGCTTGAGGAAGGATGTCAGCCCAATCAGCGGGCCCTGCAGAGTTA
CTGATGTTCTTTCAGAAGGCAGGACTGAATGGCAGAGCTAGCTTTGCAGGAATCATTACAGTTGCTCCTTTTTCTCTCTGGTTTTCCTGG
ACTATGTGACCAGGAGGACTGTCTTTTCAAAGGGAATTTAGAGCCTCACTCTCCTGGATACCTGTTACTTCCTGGCTGTCAACCCTTAAA
GGACCCCAGTGAAATGATGTGCATATGAAAATGTAGTTTGGGGATGACTCTACCTGAAAACTCCAAACAGGGAAAAAGACCTCAATTACG
AGAGGCATAGTGACCTGCCTCACCTAATCCTCACCCTTGCTGCTCCTGATGCAAAGCCAGGCACAACAAGGGAAATCCATGTCCAAAGCA
TAGTGTGGTCTCAACTCTTAGAAACTCCCTGGGTTTCCCTTTTCTCTTAGCCACATGCTAACCAGTTGCTTCTCAGTGTTTCTCTTCAAT
AGAAAAATAAGGTTTTATATGCCAGCAGCCTATCCTTGTTTTTGCATTTTAAAGACTTAGTTATTTATACGTATTTTAAAATGAAAAAAA
AATGTAAAGGTCTGTGCTTTGGATGGAAATCATTATTATTGTAATCACCCCAGCTATAGACATTTTGCACAGCTGTGGTTCTGCCTGGCC
CCACCTCTAGCATGTTAGTTTTGCAGTTAGCAAAGGTTACCTGAGGGAAATGGAGTGGGCACCTCCCGCACCAACAGTCCTGTAGCTGGA
ACCTTCCTGAGTTGACTGTTTAGTAACTCCACCTCAAAGACTGTGTTCAAAGAAAAATGTTGTTTGACTGGTTTACCCATTGCCTCCACT
CTGGTGCTGCACCCAGAGAAGTGCCAGATGTGAGAACTGGGACAGACTGAGTCATGTGCCAGCTTCCCTTGGAAAACCAAACCTAGTGAT
ACTTGACTTCCAGTGCTCAGATTTTACTAACGTTTTTCAGGATATCCACTCATCTGTCTGTCTCTTCCCTACACTTCTCTCCACCCTCTT
TTTGCATCCCTCTTACCCTCTTCCTGACTGTGGTTCATATATCCCCACCAGCCGCCATTGTCTGATCATCTTGGGAAGGTAGAGGTGACA
GTTCTCGAAAAGTCTACAGAAAGAGGCAATTCTTTTTCTGAGTTCCAGTTTGAAGGCCTGGAATTTTCACATAGCACTTGGTCGAAAATA
TCAAGCCTAAATAGGAAGTCATTTTCTGTGACACCTCTACATAGCTATTACAGATCCTAAGTCCTAGGGCATCAGCTATAAAAATTGGCC
AGTCCCAAAGACACAGTAAGTTCTAACATTCTGGTACTATCATATTTCAAGTATTTTTTCTCACTTTTTAAAAATGTTTTTCTGAACAAA
AGTGAAACAATGCCATTTATCAAACTGAGATCATTACAATCTTCAACAAGACAACTAAAACAGCTTGATGTTAGATGGGATTCTGTGACA
GTTTGTATACTGACAGGTCCTTCCAGTCTCCCTCCACAGTCCCACAAGCGGAAGTATTCTACCTGATTCCAGAGTTCATTCCAACATGCA
GTAGAATGAGGTGAATGAAGAACCAAGTGTGGGTTTTGTTTTCACAGTGCACTTGGTCAATCTAGTTTCTCTGAGTAGTGGGCTGTATTC
TAAGAAAAGCTTTCACGTAGACGTCAAAGTCTGCAAAAGAGATGAGTTAGCCACTTTAAAAAACCTGCTCTGCTTTACAAAAGATGCACA
CCAGGCTTCCTTTACAAGTGAACTCCAAGGCTGCTTGTAAAGTACCACCCTTCCTGCAGACTTTGTGGGTCGTGTCACTTGGCCTAAACA
AGTGGCCTAACATATGCATGCTCACAGCTAGTAGCATCCCTCATGCGTCCTTTGTCATACTCTGGAAAGAAAAAAACTCTGCTATCTTCA
GAGAAACCATCTATTCATACTTAAATATGGAAGCCTTTACAAGGAACTCAAAATACATTTCATTTCATTTGTACAATGAGAAAAAAGATG
AAAAGGCAAGGTTGTTATTGCAGTTGACATTGTCAGCCCTGCCTTTTGGCTTTATGTAATTTAAAATAGAAAGGGGGAAGGAGGACAAGA
CAGAAGCTCAACTTTAGAAACCATGGACATCACCTCCCTCTTTGAGAGGAGCTGCTTGTGAACCAGGCTCCAGTCTTCCTGTGGCCTCTC
ACAGTAACCCTGCCCCTTTCTTACCTCACAGGGGCAAGAGGGACTCTAAAGAGGGCGTAAGCAATAGAGGCACCTGCAGCCCTCCTTCCT
CAGCAGGAAATCAATGTGGAGCCCCAGAGGGACATTTTATCTCAGAGAGAGCATGCTGGCCACAGGACCCAGTGCAGCCCTGCTTCCCGC
ACCGTGGGTCTTTCCTGATAGCTGCAGGCTTGAGATTGCAGCCTCAGGATAGGACACGTTCAGATGCCTTCCAGACTACACACACTATGC
TTAGATTCGAGAGTCTTTCCTGACCTTAAAATTTGTCCCTTGCTTACTTTCACACTGCAGAAGATTTATATATATATTCATCATTATTTT
TGCAGCAGTACAAGTGGAAACTTCAAAAAAATCATTCCCTTTCATGTCCTGGTCTTTTTAAGTCTTGATATGTAACCATTTTCATAAATG
TCCAAACAGAGATTGTCATTCCCCTTAAAAACAGAAACAAAACACAAAACTAGTGCTTGTGAAAACACACAGCGCAAAGACAATTATCCT
ATTGCATTAAAAAAAAAATCAGTCTGCCTAGAGACATTTCATTGGCTGCATTGTCTTAATTCCCTAACGAAACTGCATCAAAATGTCAGT
TGTAATTTAGCCTCTGATCAGCTGTTAAATATTATTTAAATATTTACAGGTCCTGTGGGGTATCTCCCATTACCCATGTCGCCCTCAAAT
TACATAAGCGATCATAAAATAAGAAGAAAAAAAAAGGTCTTTAGTAGATCACAGCAGAGTTACCACTGATAAGAGTGTTGGCTTTGTTCA
GTTGTTTCTAAATTACCAGCCGTCAAGCACAGTAGCCCCTAAAACCAATTTTGAGCAAGGATAAATTCAACTCCCTCATCTGAGAACCTT
GACTTTCCAGTTGCCTTGAAGTATTGGGAATAGTAACTGTACATTTTCAATTTAATTATTTGGTATTTTATTTGACTGTCTTGGCCATGT
CATTTTATGGAAGCATTTTTAAATAGCACTTTTTGTTAGTGGTGTGGAATTTCTGCGGTTATTATTTTTTTTTTTTTTTGCAACAGATGA
AGCAAAAAAAAAAAAGCACTCATTGGAGAAATAGTGAGTGTAAAAAGAGATTTATTTTGTACAGACAGCAAAGTATCCTGTGTAATGTTG
CTGACATAAAGCACTTTGGGGGAAAAAAGTGGAAATCTGTTTTCCATAAATCACACAGACTCTTGTACATAGTTATATACACTCACGTAG
AGAAATGAACTGCATATATCATACTGGATATGGGGCCGATTTTACTCTAGAGGCACATCTGGTGCTTATTGTCATAAATCTTTTAAAGAA
TTAGGTACACTTTTTTCTATTAATATGTATAGTTTTGTGATTTGTCACAGTTATGTTTCATATAATCATAAGTTATTTTGTCTTGTTCAT
GAAGTCCTTTTTTTATGTCAAAAGTAAAATGAAGGGATTGTGCACTTGGTACAGAATAAAACTGGAAATAGAGAAGACGCCCTCCTGCCT
AAAATCCTCCTTCAGCCTGTCGGTTTAAAACACAATGGCAACCATCATTGTTTGTTTGTTTGTTTTTTTGTTTTGTTTTACCATCAGCCT
CTTACATACTGGGAATGGTAATTATAATTAAAGGCAGATGATGCGGGAGGGAATGTTCAAGTCCAGCTTTAAAATGCTGCATTGCTTTGG
GCCAGAGCTGTAGCCTGGATTTAATTATAGATATGAGGAGGAAATGGCAGTAAAAATGAATGTCTCCCTGAGTCCTTTACATGTTGGGAG

>55234_55234_5_MRRF-GLIS3_MRRF_chr9_125075665_ENST00000373729_GLIS3_chr9_3937189_ENST00000324333_length(amino acids)=567AA_BP=206
MKTVHERQHGHRQYMAYSAVPVRHFATKKAKAKGKGQSQTRVNINAALVEDIINLEEVNEEMKSVIEALKDNFNKTLNIRTSPGSLDKIA
VVTADGKLALNQISQISMKSPQLILVNMASFPECTAAAIKAIRESGMNLNPEVEGTLIRVPIPQVTREHREMLVKLAKQNTNKAKDSLRK
VRTNSMNKLKKSKDTVSEDTIRLIEKQFEGCEKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPG
CTKRYTDPSSLRKHVKAHSSKEQQARKKLRSSTELHPDLLTDCLTVQSLQPATSPRDAAAEGTVGRSPGPGPDLYSAPIFSSNYSSRSGT
AAGAVPPPHPVSHPSPGHNVQGSPHNPSSQLPPLTAVDAGAERFAPSAPSPHHISPRRVPAPSSILQRTQPPYTQQPSGSHLKSYQPETN
SSFQPNGIHVHGFYGQLQKFCPPHYPDSQRIVPPVSSCSVVPSFEDCLVPTSMGQASFDVFHRAFSTHSGITVYDLPSSSSSLFGESLRS

--------------------------------------------------------------
>55234_55234_6_MRRF-GLIS3_MRRF_chr9_125075665_ENST00000373729_GLIS3_chr9_3937189_ENST00000381971_length(transcript)=2342nt_BP=685nt
CACGAGTCTTTCCTTAGTAACCTGGGCGATAGCTGCCTCTATCAGACCCGTTTCAGAAGTTACACTGAAGACAGTGCATGAAAGACAACA
TGGCCATAGGCAATACATGGCCTATTCAGCTGTACCAGTCCGCCATTTTGCTACCAAGAAAGCCAAAGCCAAAGGGAAAGGACAGTCCCA
AACCAGAGTGAATATTAATGCTGCCTTGGTTGAGGATATAATCAACTTGGAAGAGGTGAATGAAGAAATGAAGTCTGTGATAGAAGCTCT
CAAGGATAATTTCAATAAGACTCTCAATATAAGGACCTCACCAGGATCCCTTGACAAGATTGCTGTGGTAACTGCTGACGGGAAGCTTGC
TTTAAACCAGATTAGCCAGATCTCCATGAAGTCGCCACAGCTGATTTTGGTGAATATGGCCAGCTTCCCAGAGTGTACAGCTGCAGCTAT
CAAGGCTATAAGAGAAAGTGGAATGAATCTGAACCCAGAAGTGGAAGGGACGCTAATTCGGGTACCCATTCCCCAAGTAACCAGAGAGCA
CAGAGAAATGCTGGTGAAACTGGCCAAACAGAACACCAACAAGGCCAAAGACTCTTTACGGAAGGTTCGCACCAACTCAATGAACAAGCT
GAAGAAATCCAAGGATACAGTCTCAGAGGACACCATTAGGCTAATAGAGAAACAGTTTGAAGGTTGCGAGAAGGCCTTTTCAAGGCTTGA
AAATCTCAAGATCCACTTGCGGAGCCACACAGGCGAGAAGCCGTATTTGTGCCAGCATCCGGGTTGTCAGAAGGCCTTCAGTAACTCCAG
TGACCGCGCCAAACACCAGCGGACGCATCTGGACACCAAACCTTATGCTTGTCAAATTCCAGGATGTACCAAACGCTACACAGACCCAAG
TTCCCTAAGAAAGCATGTGAAGGCACATTCTTCCAAAGAGCAACAAGCAAGGAAAAAGTTGCGGTCCAGCACAGAGCTCCATCCAGACCT
GCTCACAGATTGCCTCACCGTGCAGTCCCTGCAGCCGGCCACTTCCCCTAGAGATGCTGCTGCTGAAGGGACCGTGGGACGCTCCCCTGG
ACCCGGGCCTGACCTCTATTCAGCTCCCATTTTCTCCAGCAATTATTCAAGCCGAAGTGGAACAGCTGCTGGGGCCGTACCACCCCCACA
TCCTGTCAGTCACCCTTCTCCAGGACATAATGTACAGGGGAGCCCTCACAACCCCTCCTCCCAGTTACCTCCACTCACAGCTGTGGACGC
AGGAGCTGAGAGGTTTGCACCTTCTGCTCCATCTCCTCACCACATCAGCCCCCGGAGAGTTCCAGCTCCTTCTTCAATACTGCAAAGAAC
ACAGCCTCCCTATACCCAGCAGCCATCAGGTTCACACCTGAAGTCCTATCAGCCAGAAACAAACTCTTCTTTTCAACCAAATGGTATCCA
TGTCCATGGATTTTATGGGCAGCTGCAGAAGTTCTGTCCCCCACACTACCCCGATTCCCAGAGAATTGTGCCGCCTGTCAGCTCCTGCAG
TGTGGTGCCTTCGTTTGAGGACTGCCTAGTCCCTACATCCATGGGCCAGGCCAGTTTTGATGTTTTCCACAGAGCCTTCTCGACTCACTC
GGGCATTACAGTGTATGATTTACCTTCAAGTTCCTCGAGCCTCTTTGGGGAGTCTCTCCGCAGCGGGGCTGAAGATGCTACCTTCTTGCA
GATCAGCACCGTGGACCGCTGTCCTAGCCAGCTCTCCTCTGTCTACACCGAAGGCTAAAAGCTCTCTTGGCCACTCCTGCACACCCAGGA
CCTTGATGTTGCTTGCCACCTTTTGTTTTCGTACTCTCACAGACTGCTTGAGGAAGGATGTCAGCCCAATCAGCGGGCCCTGCAGAGTTA
CTGATGTTCTTTCAGAAGGCAGGACTGAATGGCAGAGCTAGCTTTGCAGGAATCATTACAGTTGCTCCTTTTTCTCTCTGGTTTTCCTGG
ACTATGTGACCAGGAGGACTGTCTTTTCAAAGGGAATTTAGAGCCTCACTCTCCTGGATACCTGTTACTTCCTGGCTGTCAACCCTTAAA
GGACCCCAGTGAAATGATGTGCATATGAAAATGTAGTTTGGGGATGACTCTACCTGAAAACTCCAAACAGGGAAAAAGACCTCAATTACG
AGAGGCATAGTGACCTGCCTCACCTAATCCTCACCCTTGCTGCTCCTGATGCAAAGCCAGGCACAACAAGGGAAATCCATGTCCAAAGCA
TAGTGTGGTCTCAACTCTTAGAAACTCCCTGGGTTTCCCTTTTCTCTTAGCCACATGCTAACCAGTTGCTTCTCAGTGTTTCTCTTCAAT

>55234_55234_6_MRRF-GLIS3_MRRF_chr9_125075665_ENST00000373729_GLIS3_chr9_3937189_ENST00000381971_length(amino acids)=567AA_BP=206
MKTVHERQHGHRQYMAYSAVPVRHFATKKAKAKGKGQSQTRVNINAALVEDIINLEEVNEEMKSVIEALKDNFNKTLNIRTSPGSLDKIA
VVTADGKLALNQISQISMKSPQLILVNMASFPECTAAAIKAIRESGMNLNPEVEGTLIRVPIPQVTREHREMLVKLAKQNTNKAKDSLRK
VRTNSMNKLKKSKDTVSEDTIRLIEKQFEGCEKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPG
CTKRYTDPSSLRKHVKAHSSKEQQARKKLRSSTELHPDLLTDCLTVQSLQPATSPRDAAAEGTVGRSPGPGPDLYSAPIFSSNYSSRSGT
AAGAVPPPHPVSHPSPGHNVQGSPHNPSSQLPPLTAVDAGAERFAPSAPSPHHISPRRVPAPSSILQRTQPPYTQQPSGSHLKSYQPETN
SSFQPNGIHVHGFYGQLQKFCPPHYPDSQRIVPPVSSCSVVPSFEDCLVPTSMGQASFDVFHRAFSTHSGITVYDLPSSSSSLFGESLRS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MRRF-GLIS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MRRF-GLIS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for MRRF-GLIS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource