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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MS4A13-GAS6 (FusionGDB2 ID:55249) |
Fusion Gene Summary for MS4A13-GAS6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MS4A13-GAS6 | Fusion gene ID: 55249 | Hgene | Tgene | Gene symbol | MS4A13 | GAS6 | Gene ID | 503497 | 2621 |
| Gene name | membrane spanning 4-domains A13 | growth arrest specific 6 | |
| Synonyms | - | AXLLG|AXSF | |
| Cytomap | 11q12.2 | 13q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | membrane-spanning 4-domains subfamily A member 13testis-expressed transmembrane protein 4testis-expressed transmembrane-4 protein | growth arrest-specific protein 6AXL receptor tyrosine kinase ligandAXL stimulatory factor | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q14393 | |
| Ensembl transtripts involved in fusion gene | ENST00000378185, ENST00000378186, ENST00000437058, ENST00000527948, | ENST00000327773, ENST00000357389, ENST00000355761, ENST00000418959, ENST00000450766, ENST00000476291, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 6 X 8 X 4=192 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(6/192*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MS4A13 [Title/Abstract] AND GAS6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MS4A13(60309347)-GAS6(114526421), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | GAS6 | GO:0001934 | positive regulation of protein phosphorylation | 7854420|16723520|20103767 |
| Tgene | GAS6 | GO:0006468 | protein phosphorylation | 16359517 |
| Tgene | GAS6 | GO:0006909 | phagocytosis | 21501828 |
| Tgene | GAS6 | GO:0007165 | signal transduction | 7854420|18680538 |
| Tgene | GAS6 | GO:0010628 | positive regulation of gene expression | 19657094 |
| Tgene | GAS6 | GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway | 19657094 |
| Tgene | GAS6 | GO:0018105 | peptidyl-serine phosphorylation | 18680538|20103767 |
| Tgene | GAS6 | GO:0019064 | fusion of virus membrane with host plasma membrane | 21501828 |
| Tgene | GAS6 | GO:0019079 | viral genome replication | 21501828 |
| Tgene | GAS6 | GO:0032689 | negative regulation of interferon-gamma production | 18840707 |
| Tgene | GAS6 | GO:0032715 | negative regulation of interleukin-6 production | 19657094 |
| Tgene | GAS6 | GO:0032720 | negative regulation of tumor necrosis factor production | 19657094|20103767 |
| Tgene | GAS6 | GO:0032825 | positive regulation of natural killer cell differentiation | 18840707 |
| Tgene | GAS6 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 16723520 |
| Tgene | GAS6 | GO:0035457 | cellular response to interferon-alpha | 19657094 |
| Tgene | GAS6 | GO:0035690 | cellular response to drug | 16359517 |
| Tgene | GAS6 | GO:0035754 | B cell chemotaxis | 19922767 |
| Tgene | GAS6 | GO:0043066 | negative regulation of apoptotic process | 19922767 |
| Tgene | GAS6 | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 16723520 |
| Tgene | GAS6 | GO:0043277 | apoptotic cell clearance | 21501828 |
| Tgene | GAS6 | GO:0043433 | negative regulation of DNA-binding transcription factor activity | 18680538 |
| Tgene | GAS6 | GO:0043491 | protein kinase B signaling | 16723520|20103767 |
| Tgene | GAS6 | GO:0045860 | positive regulation of protein kinase activity | 7854420 |
| Tgene | GAS6 | GO:0045892 | negative regulation of transcription, DNA-templated | 18680538 |
| Tgene | GAS6 | GO:0046718 | viral entry into host cell | 21501828 |
| Tgene | GAS6 | GO:0046813 | receptor-mediated virion attachment to host cell | 21501828 |
| Tgene | GAS6 | GO:0046827 | positive regulation of protein export from nucleus | 18680538 |
| Tgene | GAS6 | GO:0048146 | positive regulation of fibroblast proliferation | 7854420|15184064 |
| Tgene | GAS6 | GO:0050711 | negative regulation of interleukin-1 secretion | 20103767 |
| Tgene | GAS6 | GO:0050766 | positive regulation of phagocytosis | 18395422 |
| Tgene | GAS6 | GO:0051897 | positive regulation of protein kinase B signaling | 16359517|16723520|18680538 |
| Tgene | GAS6 | GO:0061098 | positive regulation of protein tyrosine kinase activity | 20103767 |
| Tgene | GAS6 | GO:0070168 | negative regulation of biomineral tissue development | 20048160 |
| Tgene | GAS6 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 15184064 |
| Tgene | GAS6 | GO:0070588 | calcium ion transmembrane transport | 18395422 |
| Tgene | GAS6 | GO:0071307 | cellular response to vitamin K | 16359517 |
| Tgene | GAS6 | GO:0072659 | protein localization to plasma membrane | 16359517 |
| Tgene | GAS6 | GO:0097241 | hematopoietic stem cell migration to bone marrow | 19922767 |
| Tgene | GAS6 | GO:1900142 | negative regulation of oligodendrocyte apoptotic process | 16723520 |
| Tgene | GAS6 | GO:1900165 | negative regulation of interleukin-6 secretion | 20103767 |
| Tgene | GAS6 | GO:2000270 | negative regulation of fibroblast apoptotic process | 16359517 |
| Tgene | GAS6 | GO:2000352 | negative regulation of endothelial cell apoptotic process | 16359517|18680538|18760998 |
| Tgene | GAS6 | GO:2000510 | positive regulation of dendritic cell chemotaxis | 19657094 |
| Tgene | GAS6 | GO:2000669 | negative regulation of dendritic cell apoptotic process | 19657094 |
| Fusion gene breakpoints across MS4A13 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across GAS6 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | BM689183 | MS4A13 | chr11 | 60309347 | - | GAS6 | chr13 | 114526421 | - |
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Fusion Gene ORF analysis for MS4A13-GAS6 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000378185 | ENST00000327773 | MS4A13 | chr11 | 60309347 | - | GAS6 | chr13 | 114526421 | - |
| intron-3CDS | ENST00000378185 | ENST00000357389 | MS4A13 | chr11 | 60309347 | - | GAS6 | chr13 | 114526421 | - |
| intron-3CDS | ENST00000378186 | ENST00000327773 | MS4A13 | chr11 | 60309347 | - | GAS6 | chr13 | 114526421 | - |
| intron-3CDS | ENST00000378186 | ENST00000357389 | MS4A13 | chr11 | 60309347 | - | GAS6 | chr13 | 114526421 | - |
| intron-3CDS | ENST00000437058 | ENST00000327773 | MS4A13 | chr11 | 60309347 | - | GAS6 | chr13 | 114526421 | - |
| intron-3CDS | ENST00000437058 | ENST00000357389 | MS4A13 | chr11 | 60309347 | - | GAS6 | chr13 | 114526421 | - |
| intron-3CDS | ENST00000527948 | ENST00000327773 | MS4A13 | chr11 | 60309347 | - | GAS6 | chr13 | 114526421 | - |
| intron-3CDS | ENST00000527948 | ENST00000357389 | MS4A13 | chr11 | 60309347 | - | GAS6 | chr13 | 114526421 | - |
| intron-intron | ENST00000378185 | ENST00000355761 | MS4A13 | chr11 | 60309347 | - | GAS6 | chr13 | 114526421 | - |
| intron-intron | ENST00000378185 | ENST00000418959 | MS4A13 | chr11 | 60309347 | - | GAS6 | chr13 | 114526421 | - |
| intron-intron | ENST00000378185 | ENST00000450766 | MS4A13 | chr11 | 60309347 | - | GAS6 | chr13 | 114526421 | - |
| intron-intron | ENST00000378185 | ENST00000476291 | MS4A13 | chr11 | 60309347 | - | GAS6 | chr13 | 114526421 | - |
| intron-intron | ENST00000378186 | ENST00000355761 | MS4A13 | chr11 | 60309347 | - | GAS6 | chr13 | 114526421 | - |
| intron-intron | ENST00000378186 | ENST00000418959 | MS4A13 | chr11 | 60309347 | - | GAS6 | chr13 | 114526421 | - |
| intron-intron | ENST00000378186 | ENST00000450766 | MS4A13 | chr11 | 60309347 | - | GAS6 | chr13 | 114526421 | - |
| intron-intron | ENST00000378186 | ENST00000476291 | MS4A13 | chr11 | 60309347 | - | GAS6 | chr13 | 114526421 | - |
| intron-intron | ENST00000437058 | ENST00000355761 | MS4A13 | chr11 | 60309347 | - | GAS6 | chr13 | 114526421 | - |
| intron-intron | ENST00000437058 | ENST00000418959 | MS4A13 | chr11 | 60309347 | - | GAS6 | chr13 | 114526421 | - |
| intron-intron | ENST00000437058 | ENST00000450766 | MS4A13 | chr11 | 60309347 | - | GAS6 | chr13 | 114526421 | - |
| intron-intron | ENST00000437058 | ENST00000476291 | MS4A13 | chr11 | 60309347 | - | GAS6 | chr13 | 114526421 | - |
| intron-intron | ENST00000527948 | ENST00000355761 | MS4A13 | chr11 | 60309347 | - | GAS6 | chr13 | 114526421 | - |
| intron-intron | ENST00000527948 | ENST00000418959 | MS4A13 | chr11 | 60309347 | - | GAS6 | chr13 | 114526421 | - |
| intron-intron | ENST00000527948 | ENST00000450766 | MS4A13 | chr11 | 60309347 | - | GAS6 | chr13 | 114526421 | - |
| intron-intron | ENST00000527948 | ENST00000476291 | MS4A13 | chr11 | 60309347 | - | GAS6 | chr13 | 114526421 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for MS4A13-GAS6 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MS4A13-GAS6 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:60309347/:114526421) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | GAS6 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. {ECO:0000269|PubMed:12364394, ECO:0000269|PubMed:18840707}.; FUNCTION: (Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed:21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed:23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed:21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed:17005688). {ECO:0000269|PubMed:17005688, ECO:0000269|PubMed:21501828, ECO:0000269|PubMed:23084921}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for MS4A13-GAS6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for MS4A13-GAS6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MS4A13-GAS6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MS4A13-GAS6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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