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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MSH2-M1AP (FusionGDB2 ID:55270)

Fusion Gene Summary for MSH2-M1AP

check button Fusion gene summary
Fusion gene informationFusion gene name: MSH2-M1AP
Fusion gene ID: 55270
HgeneTgene
Gene symbol

MSH2

M1AP

Gene ID

4436

130951

Gene namemutS homolog 2meiosis 1 associated protein
SynonymsCOCA1|FCC1|HNPCC|HNPCC1|LCFS2|hMSH2C2orf65|D6Mm5e|SPATA37
Cytomap

2p21-p16.3

2p13.1

Type of geneprotein-codingprotein-coding
DescriptionDNA mismatch repair protein Msh2DNA mismatch repair protein Msh2 transcriptmutS homolog 2, colon cancer, nonpolyposis type 1meiosis 1 arrest proteinmeiosis 1 arresting proteinspermatogenesis associated 37
Modification date2020032220200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000233146, ENST00000406134, 
ENST00000543555, ENST00000461394, 
ENST00000464686, ENST00000290536, 
ENST00000358434, ENST00000409585, 
ENST00000536235, 
Fusion gene scores* DoF score15 X 12 X 10=18006 X 6 X 5=180
# samples 237
** MAII scorelog2(23/1800*10)=-2.96829114027266
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MSH2 [Title/Abstract] AND M1AP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMSH2(47672796)-M1AP(74787418), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMSH2

GO:0006281

DNA repair

8942985

HgeneMSH2

GO:0006298

mismatch repair

7923193|11555625

HgeneMSH2

GO:0006301

postreplication repair

7923193

HgeneMSH2

GO:0045910

negative regulation of DNA recombination

17715146

HgeneMSH2

GO:0051096

positive regulation of helicase activity

17715146


check buttonFusion gene breakpoints across MSH2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across M1AP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AJ-A23M-01AMSH2chr2

47672796

+M1APchr2

74787418

-


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Fusion Gene ORF analysis for MSH2-M1AP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000233146ENST00000464686MSH2chr2

47672796

+M1APchr2

74787418

-
5CDS-5UTRENST00000406134ENST00000464686MSH2chr2

47672796

+M1APchr2

74787418

-
5CDS-5UTRENST00000543555ENST00000464686MSH2chr2

47672796

+M1APchr2

74787418

-
In-frameENST00000233146ENST00000290536MSH2chr2

47672796

+M1APchr2

74787418

-
In-frameENST00000233146ENST00000358434MSH2chr2

47672796

+M1APchr2

74787418

-
In-frameENST00000233146ENST00000409585MSH2chr2

47672796

+M1APchr2

74787418

-
In-frameENST00000233146ENST00000536235MSH2chr2

47672796

+M1APchr2

74787418

-
In-frameENST00000406134ENST00000290536MSH2chr2

47672796

+M1APchr2

74787418

-
In-frameENST00000406134ENST00000358434MSH2chr2

47672796

+M1APchr2

74787418

-
In-frameENST00000406134ENST00000409585MSH2chr2

47672796

+M1APchr2

74787418

-
In-frameENST00000406134ENST00000536235MSH2chr2

47672796

+M1APchr2

74787418

-
In-frameENST00000543555ENST00000290536MSH2chr2

47672796

+M1APchr2

74787418

-
In-frameENST00000543555ENST00000358434MSH2chr2

47672796

+M1APchr2

74787418

-
In-frameENST00000543555ENST00000409585MSH2chr2

47672796

+M1APchr2

74787418

-
In-frameENST00000543555ENST00000536235MSH2chr2

47672796

+M1APchr2

74787418

-
intron-3CDSENST00000461394ENST00000290536MSH2chr2

47672796

+M1APchr2

74787418

-
intron-3CDSENST00000461394ENST00000358434MSH2chr2

47672796

+M1APchr2

74787418

-
intron-3CDSENST00000461394ENST00000409585MSH2chr2

47672796

+M1APchr2

74787418

-
intron-3CDSENST00000461394ENST00000536235MSH2chr2

47672796

+M1APchr2

74787418

-
intron-5UTRENST00000461394ENST00000464686MSH2chr2

47672796

+M1APchr2

74787418

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000233146MSH2chr247672796+ENST00000290536M1APchr274787418-275416092231920565
ENST00000233146MSH2chr247672796+ENST00000409585M1APchr274787418-273316092231908561
ENST00000233146MSH2chr247672796+ENST00000536235M1APchr274787418-228716092231908561
ENST00000233146MSH2chr247672796+ENST00000358434M1APchr274787418-192116092231920566
ENST00000543555MSH2chr247672796+ENST00000290536M1APchr274787418-2472132771638543
ENST00000543555MSH2chr247672796+ENST00000409585M1APchr274787418-2451132771626539
ENST00000543555MSH2chr247672796+ENST00000536235M1APchr274787418-2005132771626539
ENST00000543555MSH2chr247672796+ENST00000358434M1APchr274787418-1639132771638544
ENST00000406134MSH2chr247672796+ENST00000290536M1APchr274787418-25931448621759565
ENST00000406134MSH2chr247672796+ENST00000409585M1APchr274787418-25721448621747561
ENST00000406134MSH2chr247672796+ENST00000536235M1APchr274787418-21261448621747561
ENST00000406134MSH2chr247672796+ENST00000358434M1APchr274787418-17601448621759566

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000233146ENST00000290536MSH2chr247672796+M1APchr274787418-0.0016309870.99836904
ENST00000233146ENST00000409585MSH2chr247672796+M1APchr274787418-0.0016118270.9983882
ENST00000233146ENST00000536235MSH2chr247672796+M1APchr274787418-0.0026066050.99739337
ENST00000233146ENST00000358434MSH2chr247672796+M1APchr274787418-0.00328190.9967181
ENST00000543555ENST00000290536MSH2chr247672796+M1APchr274787418-0.0010914350.9989085
ENST00000543555ENST00000409585MSH2chr247672796+M1APchr274787418-0.0010125160.9989875
ENST00000543555ENST00000536235MSH2chr247672796+M1APchr274787418-0.0012964860.9987035
ENST00000543555ENST00000358434MSH2chr247672796+M1APchr274787418-0.0017104730.9982895
ENST00000406134ENST00000290536MSH2chr247672796+M1APchr274787418-0.001545560.99845445
ENST00000406134ENST00000409585MSH2chr247672796+M1APchr274787418-0.0015415650.9984584
ENST00000406134ENST00000536235MSH2chr247672796+M1APchr274787418-0.00226510.9977349
ENST00000406134ENST00000358434MSH2chr247672796+M1APchr274787418-0.0029706460.9970293

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Fusion Genomic Features for MSH2-M1AP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MSH2-M1AP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:47672796/chr2:74787418)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMSH2chr2:47672796chr2:74787418ENST00000233146+816669_676462935.0Nucleotide bindingATP
HgeneMSH2chr2:47672796chr2:74787418ENST00000543555+917669_676396869.0Nucleotide bindingATP


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Fusion Gene Sequence for MSH2-M1AP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>55270_55270_1_MSH2-M1AP_MSH2_chr2_47672796_ENST00000233146_M1AP_chr2_74787418_ENST00000290536_length(transcript)=2754nt_BP=1609nt
GCAGTAGCTAAAGTCACCAGCGTGCGCGGGAAGCTGGGCCGCGTCTGCTTATGATTGGTTGCCGCGGCAGACTCCCACCCACCGAAACGC
AGCCCTGGAAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTG
GGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGA
GGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCA
CGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCA
GAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAG
AGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTT
TGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGT
GGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACC
AAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATAATTCAAAGAGGAGGAATTCTGATCACAGA
AAGAAAAAAAGCTGACTTTTCCACAAAAGACATTTATCAGGACCTCAACCGGTTGTTGAAAGGCAAAAAGGGAGAGCAGATGAATAGTGC
TGTATTGCCAGAAATGGAGAATCAGGTTGCAGTTTCATCACTGTCTGCGGTAATCAAGTTTTTAGAACTCTTATCAGATGATTCCAACTT
TGGACAGTTTGAACTGACTACTTTTGACTTCAGCCAGTATATGAAATTGGATATTGCAGCAGTCAGAGCCCTTAACCTTTTTCAGGGTTC
TGTTGAAGATACCACTGGCTCTCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCTCAAGGACAAAGACTTGTTAACCAGTGGAT
TAAGCAGCCTCTCATGGATAAGAACAGAATAGAGGAGAGATTGAATTTAGTGGAAGCTTTTGTAGAAGATGCAGAATTGAGGCAGACTTT
ACAAGAAGATTTACTTCGTCGATTCCCAGATCTTAACCGACTTGCCAAGAAGTTTCAAAGACAAGCAGCAAACTTACAAGATTGTTACCG
ACTCTATCAGGGTATAAATCAACTACCTAATGTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGAAATTATTGTTGGCAGTTTT
TGTGACTCCTCTTACTGATCTTCGTTCTGACTTCTCCAAGTTTCAGGAAATGATAGAAACAACTTTAGATATGGATCAGAGCATGCTGGA
CAGCCTGGAGCTGGAGCCCACCTACAACCCCTTGCATGTTCAAAGCCACCTGTACTCACACCTGAGCAGCATCTATGCCAAGCCTCAGGG
GCGGCTCCACCCACACTGGGAGAGCCGAGCTCCGAGAAAGCATCCCTGCAAGACTGGGCAGTTGCAGACCAACCGAGCTCGAGCTACTGT
GGCCCCCCTGCCTATGACTCCTGTCCCAGGCAGAGCCTCCAAGATGCCAGCAGCCAGCAAATCTTCCTCAGATGCCTTCTTCCTGCCTTC
AGAGTGGGAGAAGGATCCCTCAAGGCCCTAAGTCACCAGCACCAGAGCCCAGCTGCCCAGCTTAACCATATCCATGCTCAGGTTCACATA
ATGGCTATCTGTGGTCAGACTTGCTCTCTATCCGCCTGAGCCTCTGTGAGTGAGGGCTGACTGGGAAACAACAGCCTTCCTGTCCTGTTT
CAGTGCTGTCCCACTCCTCAAGTCTGGAAGCGACACACCCGAGCCTGTCCTTTCTCCAGCAAGGACTTTCATTTTCTTTAGAATCATTTG
CTACTGTTTACACAGGTGAAGATTAAACACCCAGTAAGCTTCTACCATTGTTAGGAGCATTCATAACTCAGAATTTCTTCTTGTAGCTCT
GTGTAAGCAGGTGGATGAGGTCAGATCACCTTTGGTAAACTGGACCTCAGGAACAAGGATGAGGTTTTGAAAGCTCATAAAAGACAAGTA
AGATTGAAATCCAAGCCTCATTTCAGAGCCTGTGCCCTTCCCACTACACCACCAGGCTTCAGCCTCCAAAGAGACAAGTGCTTGGTACCT
ACATGCAAAGTGTGTGTGCTGGGGGGTGGGAGGGCTGCCCAGAACAGGGGAGAGGATGGTGTAAAAAAAGACCTACTCCTTTCCTGTTAC
CCTCTCCCCACATGTACCAACCTTCCTGTTGCTCCCTCCATCCACAGAATAATAGCTACCATTTATAAAATGTTTACTCTGGGCTGGGAG
CAGTGGCTCACACCTGTAATCCCAACACTTTGAGAGGCTGAGGTGGGATGATCACTTGAGGCCAGGAGTTCGAGACCAGCCTGAGCAACA

>55270_55270_1_MSH2-M1AP_MSH2_chr2_47672796_ENST00000233146_M1AP_chr2_74787418_ENST00000290536_length(amino acids)=565AA_BP=461
MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK
DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD
NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSL
SAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERL
NLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKF
QEMIETTLDMDQSMLDSLELEPTYNPLHVQSHLYSHLSSIYAKPQGRLHPHWESRAPRKHPCKTGQLQTNRARATVAPLPMTPVPGRASK

--------------------------------------------------------------
>55270_55270_2_MSH2-M1AP_MSH2_chr2_47672796_ENST00000233146_M1AP_chr2_74787418_ENST00000358434_length(transcript)=1921nt_BP=1609nt
GCAGTAGCTAAAGTCACCAGCGTGCGCGGGAAGCTGGGCCGCGTCTGCTTATGATTGGTTGCCGCGGCAGACTCCCACCCACCGAAACGC
AGCCCTGGAAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTG
GGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGA
GGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCA
CGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCA
GAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAG
AGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTT
TGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGT
GGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACC
AAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATAATTCAAAGAGGAGGAATTCTGATCACAGA
AAGAAAAAAAGCTGACTTTTCCACAAAAGACATTTATCAGGACCTCAACCGGTTGTTGAAAGGCAAAAAGGGAGAGCAGATGAATAGTGC
TGTATTGCCAGAAATGGAGAATCAGGTTGCAGTTTCATCACTGTCTGCGGTAATCAAGTTTTTAGAACTCTTATCAGATGATTCCAACTT
TGGACAGTTTGAACTGACTACTTTTGACTTCAGCCAGTATATGAAATTGGATATTGCAGCAGTCAGAGCCCTTAACCTTTTTCAGGGTTC
TGTTGAAGATACCACTGGCTCTCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCTCAAGGACAAAGACTTGTTAACCAGTGGAT
TAAGCAGCCTCTCATGGATAAGAACAGAATAGAGGAGAGATTGAATTTAGTGGAAGCTTTTGTAGAAGATGCAGAATTGAGGCAGACTTT
ACAAGAAGATTTACTTCGTCGATTCCCAGATCTTAACCGACTTGCCAAGAAGTTTCAAAGACAAGCAGCAAACTTACAAGATTGTTACCG
ACTCTATCAGGGTATAAATCAACTACCTAATGTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGAAATTATTGTTGGCAGTTTT
TGTGACTCCTCTTACTGATCTTCGTTCTGACTTCTCCAAGTTTCAGGAAATGATAGAAACAACTTTAGATATGGATCAGAGCATGCTGGA
CAGCCTGGAGCTGGAGCCCACCTACAACCCCTTGCATGTTCAAAGCCACCTGTACTCACACCTGAGCAGCATCTATGCCAAGCCTCAGGG
GCGGCTCCACCCACACTGGGAGAGCCGAGCTCCGAGAAAGCATCCCTGCAAGACTGGGCAGTTGCAGACCAACCGAGCTCGAGCTACTGT
GGCCCCCCTGCCTATGACTCCTGTCCCAGGCAGAGCCTCCAAGATGCCAGCAGCCAGCAAATCTTCCTCAGATGCCTTCTTCCTGCCTTC

>55270_55270_2_MSH2-M1AP_MSH2_chr2_47672796_ENST00000233146_M1AP_chr2_74787418_ENST00000358434_length(amino acids)=566AA_BP=461
MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK
DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD
NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSL
SAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERL
NLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKF
QEMIETTLDMDQSMLDSLELEPTYNPLHVQSHLYSHLSSIYAKPQGRLHPHWESRAPRKHPCKTGQLQTNRARATVAPLPMTPVPGRASK

--------------------------------------------------------------
>55270_55270_3_MSH2-M1AP_MSH2_chr2_47672796_ENST00000233146_M1AP_chr2_74787418_ENST00000409585_length(transcript)=2733nt_BP=1609nt
GCAGTAGCTAAAGTCACCAGCGTGCGCGGGAAGCTGGGCCGCGTCTGCTTATGATTGGTTGCCGCGGCAGACTCCCACCCACCGAAACGC
AGCCCTGGAAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTG
GGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGA
GGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCA
CGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCA
GAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAG
AGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTT
TGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGT
GGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACC
AAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATAATTCAAAGAGGAGGAATTCTGATCACAGA
AAGAAAAAAAGCTGACTTTTCCACAAAAGACATTTATCAGGACCTCAACCGGTTGTTGAAAGGCAAAAAGGGAGAGCAGATGAATAGTGC
TGTATTGCCAGAAATGGAGAATCAGGTTGCAGTTTCATCACTGTCTGCGGTAATCAAGTTTTTAGAACTCTTATCAGATGATTCCAACTT
TGGACAGTTTGAACTGACTACTTTTGACTTCAGCCAGTATATGAAATTGGATATTGCAGCAGTCAGAGCCCTTAACCTTTTTCAGGGTTC
TGTTGAAGATACCACTGGCTCTCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCTCAAGGACAAAGACTTGTTAACCAGTGGAT
TAAGCAGCCTCTCATGGATAAGAACAGAATAGAGGAGAGATTGAATTTAGTGGAAGCTTTTGTAGAAGATGCAGAATTGAGGCAGACTTT
ACAAGAAGATTTACTTCGTCGATTCCCAGATCTTAACCGACTTGCCAAGAAGTTTCAAAGACAAGCAGCAAACTTACAAGATTGTTACCG
ACTCTATCAGGGTATAAATCAACTACCTAATGTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGAAATTATTGTTGGCAGTTTT
TGTGACTCCTCTTACTGATCTTCGTTCTGACTTCTCCAAGTTTCAGGAAATGATAGAAACAACTTTAGATATGGATCAGAGCATGCTGGA
CAGCCTGGAGCTGGAGCCCACCTACAACCCCTTGCATGTTCAAAGCCACCTGTACTCACACCTGAGCAGCATCTATGCCAAGCCTCAGGG
GCGGCTCCACCCACACTGGGAGAGCCGAGCTCCGAGAAAGACTGGGCAGTTGCAGACCAACCGAGCTCGAGCTACTGTGGCCCCCCTGCC
TATGACTCCTGTCCCAGGCAGAGCCTCCAAGATGCCAGCAGCCAGCAAATCTTCCTCAGATGCCTTCTTCCTGCCTTCAGAGTGGGAGAA
GGATCCCTCAAGGCCCTAAGTCACCAGCACCAGAGCCCAGCTGCCCAGCTTAACCATATCCATGCTCAGGTTCACATAATGGCTATCTGT
GGTCAGACTTGCTCTCTATCCGCCTGAGCCTCTGTGAGTGAGGGCTGACTGGGAAACAACAGCCTTCCTGTCCTGTTTCAGTGCTGTCCC
ACTCCTCAAGTCTGGAAGCGACACACCCGAGCCTGTCCTTTCTCCAGCAAGGACTTTCATTTTCTTTAGAATCATTTGCTACTGTTTACA
CAGGTGAAGATTAAACACCCAGTAAGCTTCTACCATTGTTAGGAGCATTCATAACTCAGAATTTCTTCTTGTAGCTCTGTGTAAGCAGGT
GGATGAGGTCAGATCACCTTTGGTAAACTGGACCTCAGGAACAAGGATGAGGTTTTGAAAGCTCATAAAAGACAAGTAAGATTGAAATCC
AAGCCTCATTTCAGAGCCTGTGCCCTTCCCACTACACCACCAGGCTTCAGCCTCCAAAGAGACAAGTGCTTGGTACCTACATGCAAAGTG
TGTGTGCTGGGGGGTGGGAGGGCTGCCCAGAACAGGGGAGAGGATGGTGTAAAAAAAGACCTACTCCTTTCCTGTTACCCTCTCCCCACA
TGTACCAACCTTCCTGTTGCTCCCTCCATCCACAGAATAATAGCTACCATTTATAAAATGTTTACTCTGGGCTGGGAGCAGTGGCTCACA
CCTGTAATCCCAACACTTTGAGAGGCTGAGGTGGGATGATCACTTGAGGCCAGGAGTTCGAGACCAGCCTGAGCAACACTGTGAGACCCC

>55270_55270_3_MSH2-M1AP_MSH2_chr2_47672796_ENST00000233146_M1AP_chr2_74787418_ENST00000409585_length(amino acids)=561AA_BP=461
MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK
DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD
NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSL
SAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERL
NLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKF
QEMIETTLDMDQSMLDSLELEPTYNPLHVQSHLYSHLSSIYAKPQGRLHPHWESRAPRKTGQLQTNRARATVAPLPMTPVPGRASKMPAA

--------------------------------------------------------------
>55270_55270_4_MSH2-M1AP_MSH2_chr2_47672796_ENST00000233146_M1AP_chr2_74787418_ENST00000536235_length(transcript)=2287nt_BP=1609nt
GCAGTAGCTAAAGTCACCAGCGTGCGCGGGAAGCTGGGCCGCGTCTGCTTATGATTGGTTGCCGCGGCAGACTCCCACCCACCGAAACGC
AGCCCTGGAAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTG
GGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGA
GGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCA
CGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCA
GAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAG
AGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTT
TGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGT
GGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACC
AAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATAATTCAAAGAGGAGGAATTCTGATCACAGA
AAGAAAAAAAGCTGACTTTTCCACAAAAGACATTTATCAGGACCTCAACCGGTTGTTGAAAGGCAAAAAGGGAGAGCAGATGAATAGTGC
TGTATTGCCAGAAATGGAGAATCAGGTTGCAGTTTCATCACTGTCTGCGGTAATCAAGTTTTTAGAACTCTTATCAGATGATTCCAACTT
TGGACAGTTTGAACTGACTACTTTTGACTTCAGCCAGTATATGAAATTGGATATTGCAGCAGTCAGAGCCCTTAACCTTTTTCAGGGTTC
TGTTGAAGATACCACTGGCTCTCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCTCAAGGACAAAGACTTGTTAACCAGTGGAT
TAAGCAGCCTCTCATGGATAAGAACAGAATAGAGGAGAGATTGAATTTAGTGGAAGCTTTTGTAGAAGATGCAGAATTGAGGCAGACTTT
ACAAGAAGATTTACTTCGTCGATTCCCAGATCTTAACCGACTTGCCAAGAAGTTTCAAAGACAAGCAGCAAACTTACAAGATTGTTACCG
ACTCTATCAGGGTATAAATCAACTACCTAATGTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGAAATTATTGTTGGCAGTTTT
TGTGACTCCTCTTACTGATCTTCGTTCTGACTTCTCCAAGTTTCAGGAAATGATAGAAACAACTTTAGATATGGATCAGAGCATGCTGGA
CAGCCTGGAGCTGGAGCCCACCTACAACCCCTTGCATGTTCAAAGCCACCTGTACTCACACCTGAGCAGCATCTATGCCAAGCCTCAGGG
GCGGCTCCACCCACACTGGGAGAGCCGAGCTCCGAGAAAGACTGGGCAGTTGCAGACCAACCGAGCTCGAGCTACTGTGGCCCCCCTGCC
TATGACTCCTGTCCCAGGCAGAGCCTCCAAGATGCCAGCAGCCAGCAAATCTTCCTCAGATGCCTTCTTCCTGCCTTCAGAGTGGGAGAA
GGATCCCTCAAGGCCCTAAGTCACCAGCACCAGAGCCCAGCTGCCCAGCTTAACCATATCCATGCTCAGGTTCACATAATGGCTATCTGT
GGTCAGACTTGCTCTCTATCCGCCTGAGCCTCTGTGAGTGAGGGCTGACTGGGAAACAACAGCCTTCCTGTCCTGTTTCAGTGCTGTCCC
ACTCCTCAAGTCTGGAAGCGACACACCCGAGCCTGTCCTTTCTCCAGCAAGGACTTTCATTTTCTTTAGAATCATTTGCTACTGTTTACA
CAGGTGAAGATTAAACACCCAGTAAGCTTCTACCATTGTTAGGAGCATTCATAACTCAGAATTTCTTCTTGTAGCTCTGTGTAAGCAGGT

>55270_55270_4_MSH2-M1AP_MSH2_chr2_47672796_ENST00000233146_M1AP_chr2_74787418_ENST00000536235_length(amino acids)=561AA_BP=461
MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK
DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD
NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSL
SAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERL
NLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKF
QEMIETTLDMDQSMLDSLELEPTYNPLHVQSHLYSHLSSIYAKPQGRLHPHWESRAPRKTGQLQTNRARATVAPLPMTPVPGRASKMPAA

--------------------------------------------------------------
>55270_55270_5_MSH2-M1AP_MSH2_chr2_47672796_ENST00000406134_M1AP_chr2_74787418_ENST00000290536_length(transcript)=2593nt_BP=1448nt
AAACAGCTTAGTGGGTGTGGGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGC
AGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGG
GCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGG
CAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAG
TTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTC
AGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGAC
AGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTC
TCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATAATTCAAAGAG
GAGGAATTCTGATCACAGAAAGAAAAAAAGCTGACTTTTCCACAAAAGACATTTATCAGGACCTCAACCGGTTGTTGAAAGGCAAAAAGG
GAGAGCAGATGAATAGTGCTGTATTGCCAGAAATGGAGAATCAGGTTGCAGTTTCATCACTGTCTGCGGTAATCAAGTTTTTAGAACTCT
TATCAGATGATTCCAACTTTGGACAGTTTGAACTGACTACTTTTGACTTCAGCCAGTATATGAAATTGGATATTGCAGCAGTCAGAGCCC
TTAACCTTTTTCAGGGTTCTGTTGAAGATACCACTGGCTCTCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCTCAAGGACAAA
GACTTGTTAACCAGTGGATTAAGCAGCCTCTCATGGATAAGAACAGAATAGAGGAGAGATTGAATTTAGTGGAAGCTTTTGTAGAAGATG
CAGAATTGAGGCAGACTTTACAAGAAGATTTACTTCGTCGATTCCCAGATCTTAACCGACTTGCCAAGAAGTTTCAAAGACAAGCAGCAA
ACTTACAAGATTGTTACCGACTCTATCAGGGTATAAATCAACTACCTAATGTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGA
AATTATTGTTGGCAGTTTTTGTGACTCCTCTTACTGATCTTCGTTCTGACTTCTCCAAGTTTCAGGAAATGATAGAAACAACTTTAGATA
TGGATCAGAGCATGCTGGACAGCCTGGAGCTGGAGCCCACCTACAACCCCTTGCATGTTCAAAGCCACCTGTACTCACACCTGAGCAGCA
TCTATGCCAAGCCTCAGGGGCGGCTCCACCCACACTGGGAGAGCCGAGCTCCGAGAAAGCATCCCTGCAAGACTGGGCAGTTGCAGACCA
ACCGAGCTCGAGCTACTGTGGCCCCCCTGCCTATGACTCCTGTCCCAGGCAGAGCCTCCAAGATGCCAGCAGCCAGCAAATCTTCCTCAG
ATGCCTTCTTCCTGCCTTCAGAGTGGGAGAAGGATCCCTCAAGGCCCTAAGTCACCAGCACCAGAGCCCAGCTGCCCAGCTTAACCATAT
CCATGCTCAGGTTCACATAATGGCTATCTGTGGTCAGACTTGCTCTCTATCCGCCTGAGCCTCTGTGAGTGAGGGCTGACTGGGAAACAA
CAGCCTTCCTGTCCTGTTTCAGTGCTGTCCCACTCCTCAAGTCTGGAAGCGACACACCCGAGCCTGTCCTTTCTCCAGCAAGGACTTTCA
TTTTCTTTAGAATCATTTGCTACTGTTTACACAGGTGAAGATTAAACACCCAGTAAGCTTCTACCATTGTTAGGAGCATTCATAACTCAG
AATTTCTTCTTGTAGCTCTGTGTAAGCAGGTGGATGAGGTCAGATCACCTTTGGTAAACTGGACCTCAGGAACAAGGATGAGGTTTTGAA
AGCTCATAAAAGACAAGTAAGATTGAAATCCAAGCCTCATTTCAGAGCCTGTGCCCTTCCCACTACACCACCAGGCTTCAGCCTCCAAAG
AGACAAGTGCTTGGTACCTACATGCAAAGTGTGTGTGCTGGGGGGTGGGAGGGCTGCCCAGAACAGGGGAGAGGATGGTGTAAAAAAAGA
CCTACTCCTTTCCTGTTACCCTCTCCCCACATGTACCAACCTTCCTGTTGCTCCCTCCATCCACAGAATAATAGCTACCATTTATAAAAT
GTTTACTCTGGGCTGGGAGCAGTGGCTCACACCTGTAATCCCAACACTTTGAGAGGCTGAGGTGGGATGATCACTTGAGGCCAGGAGTTC

>55270_55270_5_MSH2-M1AP_MSH2_chr2_47672796_ENST00000406134_M1AP_chr2_74787418_ENST00000290536_length(amino acids)=565AA_BP=461
MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK
DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD
NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSL
SAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERL
NLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKF
QEMIETTLDMDQSMLDSLELEPTYNPLHVQSHLYSHLSSIYAKPQGRLHPHWESRAPRKHPCKTGQLQTNRARATVAPLPMTPVPGRASK

--------------------------------------------------------------
>55270_55270_6_MSH2-M1AP_MSH2_chr2_47672796_ENST00000406134_M1AP_chr2_74787418_ENST00000358434_length(transcript)=1760nt_BP=1448nt
AAACAGCTTAGTGGGTGTGGGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGC
AGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGG
GCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGG
CAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAG
TTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTC
AGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGAC
AGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTC
TCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATAATTCAAAGAG
GAGGAATTCTGATCACAGAAAGAAAAAAAGCTGACTTTTCCACAAAAGACATTTATCAGGACCTCAACCGGTTGTTGAAAGGCAAAAAGG
GAGAGCAGATGAATAGTGCTGTATTGCCAGAAATGGAGAATCAGGTTGCAGTTTCATCACTGTCTGCGGTAATCAAGTTTTTAGAACTCT
TATCAGATGATTCCAACTTTGGACAGTTTGAACTGACTACTTTTGACTTCAGCCAGTATATGAAATTGGATATTGCAGCAGTCAGAGCCC
TTAACCTTTTTCAGGGTTCTGTTGAAGATACCACTGGCTCTCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCTCAAGGACAAA
GACTTGTTAACCAGTGGATTAAGCAGCCTCTCATGGATAAGAACAGAATAGAGGAGAGATTGAATTTAGTGGAAGCTTTTGTAGAAGATG
CAGAATTGAGGCAGACTTTACAAGAAGATTTACTTCGTCGATTCCCAGATCTTAACCGACTTGCCAAGAAGTTTCAAAGACAAGCAGCAA
ACTTACAAGATTGTTACCGACTCTATCAGGGTATAAATCAACTACCTAATGTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGA
AATTATTGTTGGCAGTTTTTGTGACTCCTCTTACTGATCTTCGTTCTGACTTCTCCAAGTTTCAGGAAATGATAGAAACAACTTTAGATA
TGGATCAGAGCATGCTGGACAGCCTGGAGCTGGAGCCCACCTACAACCCCTTGCATGTTCAAAGCCACCTGTACTCACACCTGAGCAGCA
TCTATGCCAAGCCTCAGGGGCGGCTCCACCCACACTGGGAGAGCCGAGCTCCGAGAAAGCATCCCTGCAAGACTGGGCAGTTGCAGACCA
ACCGAGCTCGAGCTACTGTGGCCCCCCTGCCTATGACTCCTGTCCCAGGCAGAGCCTCCAAGATGCCAGCAGCCAGCAAATCTTCCTCAG

>55270_55270_6_MSH2-M1AP_MSH2_chr2_47672796_ENST00000406134_M1AP_chr2_74787418_ENST00000358434_length(amino acids)=566AA_BP=461
MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK
DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD
NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSL
SAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERL
NLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKF
QEMIETTLDMDQSMLDSLELEPTYNPLHVQSHLYSHLSSIYAKPQGRLHPHWESRAPRKHPCKTGQLQTNRARATVAPLPMTPVPGRASK

--------------------------------------------------------------
>55270_55270_7_MSH2-M1AP_MSH2_chr2_47672796_ENST00000406134_M1AP_chr2_74787418_ENST00000409585_length(transcript)=2572nt_BP=1448nt
AAACAGCTTAGTGGGTGTGGGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGC
AGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGG
GCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGG
CAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAG
TTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTC
AGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGAC
AGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTC
TCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATAATTCAAAGAG
GAGGAATTCTGATCACAGAAAGAAAAAAAGCTGACTTTTCCACAAAAGACATTTATCAGGACCTCAACCGGTTGTTGAAAGGCAAAAAGG
GAGAGCAGATGAATAGTGCTGTATTGCCAGAAATGGAGAATCAGGTTGCAGTTTCATCACTGTCTGCGGTAATCAAGTTTTTAGAACTCT
TATCAGATGATTCCAACTTTGGACAGTTTGAACTGACTACTTTTGACTTCAGCCAGTATATGAAATTGGATATTGCAGCAGTCAGAGCCC
TTAACCTTTTTCAGGGTTCTGTTGAAGATACCACTGGCTCTCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCTCAAGGACAAA
GACTTGTTAACCAGTGGATTAAGCAGCCTCTCATGGATAAGAACAGAATAGAGGAGAGATTGAATTTAGTGGAAGCTTTTGTAGAAGATG
CAGAATTGAGGCAGACTTTACAAGAAGATTTACTTCGTCGATTCCCAGATCTTAACCGACTTGCCAAGAAGTTTCAAAGACAAGCAGCAA
ACTTACAAGATTGTTACCGACTCTATCAGGGTATAAATCAACTACCTAATGTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGA
AATTATTGTTGGCAGTTTTTGTGACTCCTCTTACTGATCTTCGTTCTGACTTCTCCAAGTTTCAGGAAATGATAGAAACAACTTTAGATA
TGGATCAGAGCATGCTGGACAGCCTGGAGCTGGAGCCCACCTACAACCCCTTGCATGTTCAAAGCCACCTGTACTCACACCTGAGCAGCA
TCTATGCCAAGCCTCAGGGGCGGCTCCACCCACACTGGGAGAGCCGAGCTCCGAGAAAGACTGGGCAGTTGCAGACCAACCGAGCTCGAG
CTACTGTGGCCCCCCTGCCTATGACTCCTGTCCCAGGCAGAGCCTCCAAGATGCCAGCAGCCAGCAAATCTTCCTCAGATGCCTTCTTCC
TGCCTTCAGAGTGGGAGAAGGATCCCTCAAGGCCCTAAGTCACCAGCACCAGAGCCCAGCTGCCCAGCTTAACCATATCCATGCTCAGGT
TCACATAATGGCTATCTGTGGTCAGACTTGCTCTCTATCCGCCTGAGCCTCTGTGAGTGAGGGCTGACTGGGAAACAACAGCCTTCCTGT
CCTGTTTCAGTGCTGTCCCACTCCTCAAGTCTGGAAGCGACACACCCGAGCCTGTCCTTTCTCCAGCAAGGACTTTCATTTTCTTTAGAA
TCATTTGCTACTGTTTACACAGGTGAAGATTAAACACCCAGTAAGCTTCTACCATTGTTAGGAGCATTCATAACTCAGAATTTCTTCTTG
TAGCTCTGTGTAAGCAGGTGGATGAGGTCAGATCACCTTTGGTAAACTGGACCTCAGGAACAAGGATGAGGTTTTGAAAGCTCATAAAAG
ACAAGTAAGATTGAAATCCAAGCCTCATTTCAGAGCCTGTGCCCTTCCCACTACACCACCAGGCTTCAGCCTCCAAAGAGACAAGTGCTT
GGTACCTACATGCAAAGTGTGTGTGCTGGGGGGTGGGAGGGCTGCCCAGAACAGGGGAGAGGATGGTGTAAAAAAAGACCTACTCCTTTC
CTGTTACCCTCTCCCCACATGTACCAACCTTCCTGTTGCTCCCTCCATCCACAGAATAATAGCTACCATTTATAAAATGTTTACTCTGGG
CTGGGAGCAGTGGCTCACACCTGTAATCCCAACACTTTGAGAGGCTGAGGTGGGATGATCACTTGAGGCCAGGAGTTCGAGACCAGCCTG

>55270_55270_7_MSH2-M1AP_MSH2_chr2_47672796_ENST00000406134_M1AP_chr2_74787418_ENST00000409585_length(amino acids)=561AA_BP=461
MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK
DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD
NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSL
SAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERL
NLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKF
QEMIETTLDMDQSMLDSLELEPTYNPLHVQSHLYSHLSSIYAKPQGRLHPHWESRAPRKTGQLQTNRARATVAPLPMTPVPGRASKMPAA

--------------------------------------------------------------
>55270_55270_8_MSH2-M1AP_MSH2_chr2_47672796_ENST00000406134_M1AP_chr2_74787418_ENST00000536235_length(transcript)=2126nt_BP=1448nt
AAACAGCTTAGTGGGTGTGGGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGC
AGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGG
GCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGG
CAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAG
TTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTC
AGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGAC
AGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTC
TCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATAATTCAAAGAG
GAGGAATTCTGATCACAGAAAGAAAAAAAGCTGACTTTTCCACAAAAGACATTTATCAGGACCTCAACCGGTTGTTGAAAGGCAAAAAGG
GAGAGCAGATGAATAGTGCTGTATTGCCAGAAATGGAGAATCAGGTTGCAGTTTCATCACTGTCTGCGGTAATCAAGTTTTTAGAACTCT
TATCAGATGATTCCAACTTTGGACAGTTTGAACTGACTACTTTTGACTTCAGCCAGTATATGAAATTGGATATTGCAGCAGTCAGAGCCC
TTAACCTTTTTCAGGGTTCTGTTGAAGATACCACTGGCTCTCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCTCAAGGACAAA
GACTTGTTAACCAGTGGATTAAGCAGCCTCTCATGGATAAGAACAGAATAGAGGAGAGATTGAATTTAGTGGAAGCTTTTGTAGAAGATG
CAGAATTGAGGCAGACTTTACAAGAAGATTTACTTCGTCGATTCCCAGATCTTAACCGACTTGCCAAGAAGTTTCAAAGACAAGCAGCAA
ACTTACAAGATTGTTACCGACTCTATCAGGGTATAAATCAACTACCTAATGTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGA
AATTATTGTTGGCAGTTTTTGTGACTCCTCTTACTGATCTTCGTTCTGACTTCTCCAAGTTTCAGGAAATGATAGAAACAACTTTAGATA
TGGATCAGAGCATGCTGGACAGCCTGGAGCTGGAGCCCACCTACAACCCCTTGCATGTTCAAAGCCACCTGTACTCACACCTGAGCAGCA
TCTATGCCAAGCCTCAGGGGCGGCTCCACCCACACTGGGAGAGCCGAGCTCCGAGAAAGACTGGGCAGTTGCAGACCAACCGAGCTCGAG
CTACTGTGGCCCCCCTGCCTATGACTCCTGTCCCAGGCAGAGCCTCCAAGATGCCAGCAGCCAGCAAATCTTCCTCAGATGCCTTCTTCC
TGCCTTCAGAGTGGGAGAAGGATCCCTCAAGGCCCTAAGTCACCAGCACCAGAGCCCAGCTGCCCAGCTTAACCATATCCATGCTCAGGT
TCACATAATGGCTATCTGTGGTCAGACTTGCTCTCTATCCGCCTGAGCCTCTGTGAGTGAGGGCTGACTGGGAAACAACAGCCTTCCTGT
CCTGTTTCAGTGCTGTCCCACTCCTCAAGTCTGGAAGCGACACACCCGAGCCTGTCCTTTCTCCAGCAAGGACTTTCATTTTCTTTAGAA
TCATTTGCTACTGTTTACACAGGTGAAGATTAAACACCCAGTAAGCTTCTACCATTGTTAGGAGCATTCATAACTCAGAATTTCTTCTTG

>55270_55270_8_MSH2-M1AP_MSH2_chr2_47672796_ENST00000406134_M1AP_chr2_74787418_ENST00000536235_length(amino acids)=561AA_BP=461
MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK
DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD
NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSL
SAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERL
NLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKF
QEMIETTLDMDQSMLDSLELEPTYNPLHVQSHLYSHLSSIYAKPQGRLHPHWESRAPRKTGQLQTNRARATVAPLPMTPVPGRASKMPAA

--------------------------------------------------------------
>55270_55270_9_MSH2-M1AP_MSH2_chr2_47672796_ENST00000543555_M1AP_chr2_74787418_ENST00000290536_length(transcript)=2472nt_BP=1327nt
AAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTGGGGTCGCG
CATTTTCTTCAACCAGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCT
TAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAA
GGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGA
TATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACA
GAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGT
TTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATAATTCAAAGAGGAGGAATTCTGATCACAGAAAGAAAAAAAGC
TGACTTTTCCACAAAAGACATTTATCAGGACCTCAACCGGTTGTTGAAAGGCAAAAAGGGAGAGCAGATGAATAGTGCTGTATTGCCAGA
AATGGAGAATCAGGTTGCAGTTTCATCACTGTCTGCGGTAATCAAGTTTTTAGAACTCTTATCAGATGATTCCAACTTTGGACAGTTTGA
ACTGACTACTTTTGACTTCAGCCAGTATATGAAATTGGATATTGCAGCAGTCAGAGCCCTTAACCTTTTTCAGGGTTCTGTTGAAGATAC
CACTGGCTCTCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCTCAAGGACAAAGACTTGTTAACCAGTGGATTAAGCAGCCTCT
CATGGATAAGAACAGAATAGAGGAGAGATTGAATTTAGTGGAAGCTTTTGTAGAAGATGCAGAATTGAGGCAGACTTTACAAGAAGATTT
ACTTCGTCGATTCCCAGATCTTAACCGACTTGCCAAGAAGTTTCAAAGACAAGCAGCAAACTTACAAGATTGTTACCGACTCTATCAGGG
TATAAATCAACTACCTAATGTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGAAATTATTGTTGGCAGTTTTTGTGACTCCTCT
TACTGATCTTCGTTCTGACTTCTCCAAGTTTCAGGAAATGATAGAAACAACTTTAGATATGGATCAGAGCATGCTGGACAGCCTGGAGCT
GGAGCCCACCTACAACCCCTTGCATGTTCAAAGCCACCTGTACTCACACCTGAGCAGCATCTATGCCAAGCCTCAGGGGCGGCTCCACCC
ACACTGGGAGAGCCGAGCTCCGAGAAAGCATCCCTGCAAGACTGGGCAGTTGCAGACCAACCGAGCTCGAGCTACTGTGGCCCCCCTGCC
TATGACTCCTGTCCCAGGCAGAGCCTCCAAGATGCCAGCAGCCAGCAAATCTTCCTCAGATGCCTTCTTCCTGCCTTCAGAGTGGGAGAA
GGATCCCTCAAGGCCCTAAGTCACCAGCACCAGAGCCCAGCTGCCCAGCTTAACCATATCCATGCTCAGGTTCACATAATGGCTATCTGT
GGTCAGACTTGCTCTCTATCCGCCTGAGCCTCTGTGAGTGAGGGCTGACTGGGAAACAACAGCCTTCCTGTCCTGTTTCAGTGCTGTCCC
ACTCCTCAAGTCTGGAAGCGACACACCCGAGCCTGTCCTTTCTCCAGCAAGGACTTTCATTTTCTTTAGAATCATTTGCTACTGTTTACA
CAGGTGAAGATTAAACACCCAGTAAGCTTCTACCATTGTTAGGAGCATTCATAACTCAGAATTTCTTCTTGTAGCTCTGTGTAAGCAGGT
GGATGAGGTCAGATCACCTTTGGTAAACTGGACCTCAGGAACAAGGATGAGGTTTTGAAAGCTCATAAAAGACAAGTAAGATTGAAATCC
AAGCCTCATTTCAGAGCCTGTGCCCTTCCCACTACACCACCAGGCTTCAGCCTCCAAAGAGACAAGTGCTTGGTACCTACATGCAAAGTG
TGTGTGCTGGGGGGTGGGAGGGCTGCCCAGAACAGGGGAGAGGATGGTGTAAAAAAAGACCTACTCCTTTCCTGTTACCCTCTCCCCACA
TGTACCAACCTTCCTGTTGCTCCCTCCATCCACAGAATAATAGCTACCATTTATAAAATGTTTACTCTGGGCTGGGAGCAGTGGCTCACA
CCTGTAATCCCAACACTTTGAGAGGCTGAGGTGGGATGATCACTTGAGGCCAGGAGTTCGAGACCAGCCTGAGCAACACTGTGAGACCCC

>55270_55270_9_MSH2-M1AP_MSH2_chr2_47672796_ENST00000543555_M1AP_chr2_74787418_ENST00000290536_length(amino acids)=543AA_BP=439
MGVVAVAGRRSGDVGGEAGNSLVGVGSRIFFNQEVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKAS
KENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECVLP
GGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELT
TFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQTLQEDLLR
RFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQSMLDSLELEP
TYNPLHVQSHLYSHLSSIYAKPQGRLHPHWESRAPRKHPCKTGQLQTNRARATVAPLPMTPVPGRASKMPAASKSSSDAFFLPSEWEKDP

--------------------------------------------------------------
>55270_55270_10_MSH2-M1AP_MSH2_chr2_47672796_ENST00000543555_M1AP_chr2_74787418_ENST00000358434_length(transcript)=1639nt_BP=1327nt
AAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTGGGGTCGCG
CATTTTCTTCAACCAGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCT
TAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAA
GGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGA
TATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACA
GAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGT
TTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATAATTCAAAGAGGAGGAATTCTGATCACAGAAAGAAAAAAAGC
TGACTTTTCCACAAAAGACATTTATCAGGACCTCAACCGGTTGTTGAAAGGCAAAAAGGGAGAGCAGATGAATAGTGCTGTATTGCCAGA
AATGGAGAATCAGGTTGCAGTTTCATCACTGTCTGCGGTAATCAAGTTTTTAGAACTCTTATCAGATGATTCCAACTTTGGACAGTTTGA
ACTGACTACTTTTGACTTCAGCCAGTATATGAAATTGGATATTGCAGCAGTCAGAGCCCTTAACCTTTTTCAGGGTTCTGTTGAAGATAC
CACTGGCTCTCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCTCAAGGACAAAGACTTGTTAACCAGTGGATTAAGCAGCCTCT
CATGGATAAGAACAGAATAGAGGAGAGATTGAATTTAGTGGAAGCTTTTGTAGAAGATGCAGAATTGAGGCAGACTTTACAAGAAGATTT
ACTTCGTCGATTCCCAGATCTTAACCGACTTGCCAAGAAGTTTCAAAGACAAGCAGCAAACTTACAAGATTGTTACCGACTCTATCAGGG
TATAAATCAACTACCTAATGTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGAAATTATTGTTGGCAGTTTTTGTGACTCCTCT
TACTGATCTTCGTTCTGACTTCTCCAAGTTTCAGGAAATGATAGAAACAACTTTAGATATGGATCAGAGCATGCTGGACAGCCTGGAGCT
GGAGCCCACCTACAACCCCTTGCATGTTCAAAGCCACCTGTACTCACACCTGAGCAGCATCTATGCCAAGCCTCAGGGGCGGCTCCACCC
ACACTGGGAGAGCCGAGCTCCGAGAAAGCATCCCTGCAAGACTGGGCAGTTGCAGACCAACCGAGCTCGAGCTACTGTGGCCCCCCTGCC
TATGACTCCTGTCCCAGGCAGAGCCTCCAAGATGCCAGCAGCCAGCAAATCTTCCTCAGATGCCTTCTTCCTGCCTTCAGAGTGGGAGAA

>55270_55270_10_MSH2-M1AP_MSH2_chr2_47672796_ENST00000543555_M1AP_chr2_74787418_ENST00000358434_length(amino acids)=544AA_BP=439
MGVVAVAGRRSGDVGGEAGNSLVGVGSRIFFNQEVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKAS
KENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECVLP
GGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELT
TFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQTLQEDLLR
RFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQSMLDSLELEP
TYNPLHVQSHLYSHLSSIYAKPQGRLHPHWESRAPRKHPCKTGQLQTNRARATVAPLPMTPVPGRASKMPAASKSSSDAFFLPSEWEKDP

--------------------------------------------------------------
>55270_55270_11_MSH2-M1AP_MSH2_chr2_47672796_ENST00000543555_M1AP_chr2_74787418_ENST00000409585_length(transcript)=2451nt_BP=1327nt
AAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTGGGGTCGCG
CATTTTCTTCAACCAGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCT
TAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAA
GGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGA
TATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACA
GAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGT
TTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATAATTCAAAGAGGAGGAATTCTGATCACAGAAAGAAAAAAAGC
TGACTTTTCCACAAAAGACATTTATCAGGACCTCAACCGGTTGTTGAAAGGCAAAAAGGGAGAGCAGATGAATAGTGCTGTATTGCCAGA
AATGGAGAATCAGGTTGCAGTTTCATCACTGTCTGCGGTAATCAAGTTTTTAGAACTCTTATCAGATGATTCCAACTTTGGACAGTTTGA
ACTGACTACTTTTGACTTCAGCCAGTATATGAAATTGGATATTGCAGCAGTCAGAGCCCTTAACCTTTTTCAGGGTTCTGTTGAAGATAC
CACTGGCTCTCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCTCAAGGACAAAGACTTGTTAACCAGTGGATTAAGCAGCCTCT
CATGGATAAGAACAGAATAGAGGAGAGATTGAATTTAGTGGAAGCTTTTGTAGAAGATGCAGAATTGAGGCAGACTTTACAAGAAGATTT
ACTTCGTCGATTCCCAGATCTTAACCGACTTGCCAAGAAGTTTCAAAGACAAGCAGCAAACTTACAAGATTGTTACCGACTCTATCAGGG
TATAAATCAACTACCTAATGTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGAAATTATTGTTGGCAGTTTTTGTGACTCCTCT
TACTGATCTTCGTTCTGACTTCTCCAAGTTTCAGGAAATGATAGAAACAACTTTAGATATGGATCAGAGCATGCTGGACAGCCTGGAGCT
GGAGCCCACCTACAACCCCTTGCATGTTCAAAGCCACCTGTACTCACACCTGAGCAGCATCTATGCCAAGCCTCAGGGGCGGCTCCACCC
ACACTGGGAGAGCCGAGCTCCGAGAAAGACTGGGCAGTTGCAGACCAACCGAGCTCGAGCTACTGTGGCCCCCCTGCCTATGACTCCTGT
CCCAGGCAGAGCCTCCAAGATGCCAGCAGCCAGCAAATCTTCCTCAGATGCCTTCTTCCTGCCTTCAGAGTGGGAGAAGGATCCCTCAAG
GCCCTAAGTCACCAGCACCAGAGCCCAGCTGCCCAGCTTAACCATATCCATGCTCAGGTTCACATAATGGCTATCTGTGGTCAGACTTGC
TCTCTATCCGCCTGAGCCTCTGTGAGTGAGGGCTGACTGGGAAACAACAGCCTTCCTGTCCTGTTTCAGTGCTGTCCCACTCCTCAAGTC
TGGAAGCGACACACCCGAGCCTGTCCTTTCTCCAGCAAGGACTTTCATTTTCTTTAGAATCATTTGCTACTGTTTACACAGGTGAAGATT
AAACACCCAGTAAGCTTCTACCATTGTTAGGAGCATTCATAACTCAGAATTTCTTCTTGTAGCTCTGTGTAAGCAGGTGGATGAGGTCAG
ATCACCTTTGGTAAACTGGACCTCAGGAACAAGGATGAGGTTTTGAAAGCTCATAAAAGACAAGTAAGATTGAAATCCAAGCCTCATTTC
AGAGCCTGTGCCCTTCCCACTACACCACCAGGCTTCAGCCTCCAAAGAGACAAGTGCTTGGTACCTACATGCAAAGTGTGTGTGCTGGGG
GGTGGGAGGGCTGCCCAGAACAGGGGAGAGGATGGTGTAAAAAAAGACCTACTCCTTTCCTGTTACCCTCTCCCCACATGTACCAACCTT
CCTGTTGCTCCCTCCATCCACAGAATAATAGCTACCATTTATAAAATGTTTACTCTGGGCTGGGAGCAGTGGCTCACACCTGTAATCCCA
ACACTTTGAGAGGCTGAGGTGGGATGATCACTTGAGGCCAGGAGTTCGAGACCAGCCTGAGCAACACTGTGAGACCCCCCCGCCATCTCT

>55270_55270_11_MSH2-M1AP_MSH2_chr2_47672796_ENST00000543555_M1AP_chr2_74787418_ENST00000409585_length(amino acids)=539AA_BP=439
MGVVAVAGRRSGDVGGEAGNSLVGVGSRIFFNQEVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKAS
KENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECVLP
GGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELT
TFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQTLQEDLLR
RFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQSMLDSLELEP

--------------------------------------------------------------
>55270_55270_12_MSH2-M1AP_MSH2_chr2_47672796_ENST00000543555_M1AP_chr2_74787418_ENST00000536235_length(transcript)=2005nt_BP=1327nt
AAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTGGGGTCGCG
CATTTTCTTCAACCAGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCT
TAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAA
GGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGA
TATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACA
GAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGT
TTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATAATTCAAAGAGGAGGAATTCTGATCACAGAAAGAAAAAAAGC
TGACTTTTCCACAAAAGACATTTATCAGGACCTCAACCGGTTGTTGAAAGGCAAAAAGGGAGAGCAGATGAATAGTGCTGTATTGCCAGA
AATGGAGAATCAGGTTGCAGTTTCATCACTGTCTGCGGTAATCAAGTTTTTAGAACTCTTATCAGATGATTCCAACTTTGGACAGTTTGA
ACTGACTACTTTTGACTTCAGCCAGTATATGAAATTGGATATTGCAGCAGTCAGAGCCCTTAACCTTTTTCAGGGTTCTGTTGAAGATAC
CACTGGCTCTCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCTCAAGGACAAAGACTTGTTAACCAGTGGATTAAGCAGCCTCT
CATGGATAAGAACAGAATAGAGGAGAGATTGAATTTAGTGGAAGCTTTTGTAGAAGATGCAGAATTGAGGCAGACTTTACAAGAAGATTT
ACTTCGTCGATTCCCAGATCTTAACCGACTTGCCAAGAAGTTTCAAAGACAAGCAGCAAACTTACAAGATTGTTACCGACTCTATCAGGG
TATAAATCAACTACCTAATGTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGAAATTATTGTTGGCAGTTTTTGTGACTCCTCT
TACTGATCTTCGTTCTGACTTCTCCAAGTTTCAGGAAATGATAGAAACAACTTTAGATATGGATCAGAGCATGCTGGACAGCCTGGAGCT
GGAGCCCACCTACAACCCCTTGCATGTTCAAAGCCACCTGTACTCACACCTGAGCAGCATCTATGCCAAGCCTCAGGGGCGGCTCCACCC
ACACTGGGAGAGCCGAGCTCCGAGAAAGACTGGGCAGTTGCAGACCAACCGAGCTCGAGCTACTGTGGCCCCCCTGCCTATGACTCCTGT
CCCAGGCAGAGCCTCCAAGATGCCAGCAGCCAGCAAATCTTCCTCAGATGCCTTCTTCCTGCCTTCAGAGTGGGAGAAGGATCCCTCAAG
GCCCTAAGTCACCAGCACCAGAGCCCAGCTGCCCAGCTTAACCATATCCATGCTCAGGTTCACATAATGGCTATCTGTGGTCAGACTTGC
TCTCTATCCGCCTGAGCCTCTGTGAGTGAGGGCTGACTGGGAAACAACAGCCTTCCTGTCCTGTTTCAGTGCTGTCCCACTCCTCAAGTC
TGGAAGCGACACACCCGAGCCTGTCCTTTCTCCAGCAAGGACTTTCATTTTCTTTAGAATCATTTGCTACTGTTTACACAGGTGAAGATT
AAACACCCAGTAAGCTTCTACCATTGTTAGGAGCATTCATAACTCAGAATTTCTTCTTGTAGCTCTGTGTAAGCAGGTGGATGAGGTCAG

>55270_55270_12_MSH2-M1AP_MSH2_chr2_47672796_ENST00000543555_M1AP_chr2_74787418_ENST00000536235_length(amino acids)=539AA_BP=439
MGVVAVAGRRSGDVGGEAGNSLVGVGSRIFFNQEVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKAS
KENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECVLP
GGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELT
TFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQTLQEDLLR
RFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQSMLDSLELEP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MSH2-M1AP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMSH2chr2:47672796chr2:74787418ENST00000233146+816601_671462.0935.0EXO1
HgeneMSH2chr2:47672796chr2:74787418ENST00000543555+917601_671396.0869.0EXO1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MSH2-M1AP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MSH2-M1AP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource