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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MSH6-FBXO11 (FusionGDB2 ID:55291)

Fusion Gene Summary for MSH6-FBXO11

check button Fusion gene summary
Fusion gene informationFusion gene name: MSH6-FBXO11
Fusion gene ID: 55291
HgeneTgene
Gene symbol

MSH6

FBXO11

Gene ID

2956

80204

Gene namemutS homolog 6F-box protein 11
SynonymsGTBP|GTMBP|HNPCC5|HSAP|p160FBX11|IDDFBA|PRMT9|UBR6|UG063H01|VIT1
Cytomap

2p16.3

2p16.3

Type of geneprotein-codingprotein-coding
DescriptionDNA mismatch repair protein Msh6G/T mismatch-binding proteinmutS protein homolog 6mutS-alpha 160 kDa subunitsperm-associated proteinF-box only protein 11protein arginine N-methyltransferase 9ubiquitin protein ligase E3 component n-recognin 6vitiligo-associated protein 1vitiligo-associated protein VIT-1
Modification date2020031320200327
UniProtAcc

P52701

Q86XK2

Ensembl transtripts involved in fusion geneENST00000234420, ENST00000538136, 
ENST00000540021, ENST00000607272, 
ENST00000316377, ENST00000402508, 
ENST00000403359, ENST00000378314, 
ENST00000405808, ENST00000434523, 
ENST00000480038, 
Fusion gene scores* DoF score5 X 13 X 5=3258 X 12 X 6=576
# samples 1315
** MAII scorelog2(13/325*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/576*10)=-1.94110631094643
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MSH6 [Title/Abstract] AND FBXO11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMSH6(48033753)-FBXO11(48034069), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMSH6

GO:0006281

DNA repair

8942985

HgeneMSH6

GO:0006298

mismatch repair

10871409|23622243

HgeneMSH6

GO:0045910

negative regulation of DNA recombination

17715146

HgeneMSH6

GO:0051096

positive regulation of helicase activity

17715146

TgeneFBXO11

GO:0006464

cellular protein modification process

16487488


check buttonFusion gene breakpoints across MSH6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FBXO11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-CJ-6033-01AMSH6chr2

48033764

-FBXO11chr2

48034059

-
ChimerDB4STADTCGA-2H-A9GL-01A8MSH6chr2

48033753

+FBXO11chr2

48034069

-
ChimerDB4STADTCGA-L5-A4OM-01A4MSH6chr2

48033781

+FBXO11chr2

48034071

-
ChimerDB4STADTCGA-L5-A4OR-01A4MSH6chr2

48032786

-FBXO11chr2

48034069

-
ChimerDB4STADTCGA-Q9-A6FW-01A7MSH6chr2

48033753

+FBXO11chr2

48034069

-
ChimerDB4STADTCGA-R6-A8WC-01A6MSH6chr2

48032766

-FBXO11chr2

48034076

-
ChimerDB4UCECTCGA-QS-A5YR-01AMSH6chr2

48033706

-FBXO11chr2

48034058

-
ChiTaRS5.0N/ABG779363MSH6chr2

48031135

-FBXO11chr2

48034721

-


Top

Fusion Gene ORF analysis for MSH6-FBXO11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000234420ENST00000316377MSH6chr2

48033781

+FBXO11chr2

48034071

-
5CDS-3UTRENST00000234420ENST00000316377MSH6chr2

48032786

-FBXO11chr2

48034069

-
5CDS-3UTRENST00000234420ENST00000316377MSH6chr2

48033753

+FBXO11chr2

48034069

-
5CDS-3UTRENST00000234420ENST00000316377MSH6chr2

48032766

-FBXO11chr2

48034076

-
5CDS-3UTRENST00000234420ENST00000402508MSH6chr2

48033781

+FBXO11chr2

48034071

-
5CDS-3UTRENST00000234420ENST00000402508MSH6chr2

48032786

-FBXO11chr2

48034069

-
5CDS-3UTRENST00000234420ENST00000402508MSH6chr2

48033753

+FBXO11chr2

48034069

-
5CDS-3UTRENST00000234420ENST00000402508MSH6chr2

48032766

-FBXO11chr2

48034076

-
5CDS-3UTRENST00000234420ENST00000403359MSH6chr2

48033781

+FBXO11chr2

48034071

-
5CDS-3UTRENST00000234420ENST00000403359MSH6chr2

48032786

-FBXO11chr2

48034069

-
5CDS-3UTRENST00000234420ENST00000403359MSH6chr2

48033753

+FBXO11chr2

48034069

-
5CDS-3UTRENST00000234420ENST00000403359MSH6chr2

48032766

-FBXO11chr2

48034076

-
5CDS-3UTRENST00000538136ENST00000316377MSH6chr2

48033781

+FBXO11chr2

48034071

-
5CDS-3UTRENST00000538136ENST00000316377MSH6chr2

48032786

-FBXO11chr2

48034069

-
5CDS-3UTRENST00000538136ENST00000316377MSH6chr2

48033753

+FBXO11chr2

48034069

-
5CDS-3UTRENST00000538136ENST00000316377MSH6chr2

48032766

-FBXO11chr2

48034076

-
5CDS-3UTRENST00000538136ENST00000402508MSH6chr2

48033781

+FBXO11chr2

48034071

-
5CDS-3UTRENST00000538136ENST00000402508MSH6chr2

48032786

-FBXO11chr2

48034069

-
5CDS-3UTRENST00000538136ENST00000402508MSH6chr2

48033753

+FBXO11chr2

48034069

-
5CDS-3UTRENST00000538136ENST00000402508MSH6chr2

48032766

-FBXO11chr2

48034076

-
5CDS-3UTRENST00000538136ENST00000403359MSH6chr2

48033781

+FBXO11chr2

48034071

-
5CDS-3UTRENST00000538136ENST00000403359MSH6chr2

48032786

-FBXO11chr2

48034069

-
5CDS-3UTRENST00000538136ENST00000403359MSH6chr2

48033753

+FBXO11chr2

48034069

-
5CDS-3UTRENST00000538136ENST00000403359MSH6chr2

48032766

-FBXO11chr2

48034076

-
5CDS-3UTRENST00000540021ENST00000316377MSH6chr2

48033781

+FBXO11chr2

48034071

-
5CDS-3UTRENST00000540021ENST00000316377MSH6chr2

48032786

-FBXO11chr2

48034069

-
5CDS-3UTRENST00000540021ENST00000316377MSH6chr2

48033753

+FBXO11chr2

48034069

-
5CDS-3UTRENST00000540021ENST00000316377MSH6chr2

48032766

-FBXO11chr2

48034076

-
5CDS-3UTRENST00000540021ENST00000402508MSH6chr2

48033781

+FBXO11chr2

48034071

-
5CDS-3UTRENST00000540021ENST00000402508MSH6chr2

48032786

-FBXO11chr2

48034069

-
5CDS-3UTRENST00000540021ENST00000402508MSH6chr2

48033753

+FBXO11chr2

48034069

-
5CDS-3UTRENST00000540021ENST00000402508MSH6chr2

48032766

-FBXO11chr2

48034076

-
5CDS-3UTRENST00000540021ENST00000403359MSH6chr2

48033781

+FBXO11chr2

48034071

-
5CDS-3UTRENST00000540021ENST00000403359MSH6chr2

48032786

-FBXO11chr2

48034069

-
5CDS-3UTRENST00000540021ENST00000403359MSH6chr2

48033753

+FBXO11chr2

48034069

-
5CDS-3UTRENST00000540021ENST00000403359MSH6chr2

48032766

-FBXO11chr2

48034076

-
5CDS-intronENST00000234420ENST00000316377MSH6chr2

48033764

-FBXO11chr2

48034059

-
5CDS-intronENST00000234420ENST00000316377MSH6chr2

48033706

-FBXO11chr2

48034058

-
5CDS-intronENST00000234420ENST00000378314MSH6chr2

48033764

-FBXO11chr2

48034059

-
5CDS-intronENST00000234420ENST00000378314MSH6chr2

48033781

+FBXO11chr2

48034071

-
5CDS-intronENST00000234420ENST00000378314MSH6chr2

48032786

-FBXO11chr2

48034069

-
5CDS-intronENST00000234420ENST00000378314MSH6chr2

48033753

+FBXO11chr2

48034069

-
5CDS-intronENST00000234420ENST00000378314MSH6chr2

48032766

-FBXO11chr2

48034076

-
5CDS-intronENST00000234420ENST00000378314MSH6chr2

48033706

-FBXO11chr2

48034058

-
5CDS-intronENST00000234420ENST00000402508MSH6chr2

48033764

-FBXO11chr2

48034059

-
5CDS-intronENST00000234420ENST00000402508MSH6chr2

48033706

-FBXO11chr2

48034058

-
5CDS-intronENST00000234420ENST00000403359MSH6chr2

48033764

-FBXO11chr2

48034059

-
5CDS-intronENST00000234420ENST00000403359MSH6chr2

48033706

-FBXO11chr2

48034058

-
5CDS-intronENST00000234420ENST00000405808MSH6chr2

48033764

-FBXO11chr2

48034059

-
5CDS-intronENST00000234420ENST00000405808MSH6chr2

48033781

+FBXO11chr2

48034071

-
5CDS-intronENST00000234420ENST00000405808MSH6chr2

48032786

-FBXO11chr2

48034069

-
5CDS-intronENST00000234420ENST00000405808MSH6chr2

48033753

+FBXO11chr2

48034069

-
5CDS-intronENST00000234420ENST00000405808MSH6chr2

48032766

-FBXO11chr2

48034076

-
5CDS-intronENST00000234420ENST00000405808MSH6chr2

48033706

-FBXO11chr2

48034058

-
5CDS-intronENST00000234420ENST00000434523MSH6chr2

48033764

-FBXO11chr2

48034059

-
5CDS-intronENST00000234420ENST00000434523MSH6chr2

48033781

+FBXO11chr2

48034071

-
5CDS-intronENST00000234420ENST00000434523MSH6chr2

48032786

-FBXO11chr2

48034069

-
5CDS-intronENST00000234420ENST00000434523MSH6chr2

48033753

+FBXO11chr2

48034069

-
5CDS-intronENST00000234420ENST00000434523MSH6chr2

48032766

-FBXO11chr2

48034076

-
5CDS-intronENST00000234420ENST00000434523MSH6chr2

48033706

-FBXO11chr2

48034058

-
5CDS-intronENST00000234420ENST00000480038MSH6chr2

48033764

-FBXO11chr2

48034059

-
5CDS-intronENST00000234420ENST00000480038MSH6chr2

48033781

+FBXO11chr2

48034071

-
5CDS-intronENST00000234420ENST00000480038MSH6chr2

48032786

-FBXO11chr2

48034069

-
5CDS-intronENST00000234420ENST00000480038MSH6chr2

48033753

+FBXO11chr2

48034069

-
5CDS-intronENST00000234420ENST00000480038MSH6chr2

48032766

-FBXO11chr2

48034076

-
5CDS-intronENST00000234420ENST00000480038MSH6chr2

48033706

-FBXO11chr2

48034058

-
5CDS-intronENST00000538136ENST00000316377MSH6chr2

48033764

-FBXO11chr2

48034059

-
5CDS-intronENST00000538136ENST00000316377MSH6chr2

48033706

-FBXO11chr2

48034058

-
5CDS-intronENST00000538136ENST00000378314MSH6chr2

48033764

-FBXO11chr2

48034059

-
5CDS-intronENST00000538136ENST00000378314MSH6chr2

48033781

+FBXO11chr2

48034071

-
5CDS-intronENST00000538136ENST00000378314MSH6chr2

48032786

-FBXO11chr2

48034069

-
5CDS-intronENST00000538136ENST00000378314MSH6chr2

48033753

+FBXO11chr2

48034069

-
5CDS-intronENST00000538136ENST00000378314MSH6chr2

48032766

-FBXO11chr2

48034076

-
5CDS-intronENST00000538136ENST00000378314MSH6chr2

48033706

-FBXO11chr2

48034058

-
5CDS-intronENST00000538136ENST00000402508MSH6chr2

48033764

-FBXO11chr2

48034059

-
5CDS-intronENST00000538136ENST00000402508MSH6chr2

48033706

-FBXO11chr2

48034058

-
5CDS-intronENST00000538136ENST00000403359MSH6chr2

48033764

-FBXO11chr2

48034059

-
5CDS-intronENST00000538136ENST00000403359MSH6chr2

48033706

-FBXO11chr2

48034058

-
5CDS-intronENST00000538136ENST00000405808MSH6chr2

48033764

-FBXO11chr2

48034059

-
5CDS-intronENST00000538136ENST00000405808MSH6chr2

48033781

+FBXO11chr2

48034071

-
5CDS-intronENST00000538136ENST00000405808MSH6chr2

48032786

-FBXO11chr2

48034069

-
5CDS-intronENST00000538136ENST00000405808MSH6chr2

48033753

+FBXO11chr2

48034069

-
5CDS-intronENST00000538136ENST00000405808MSH6chr2

48032766

-FBXO11chr2

48034076

-
5CDS-intronENST00000538136ENST00000405808MSH6chr2

48033706

-FBXO11chr2

48034058

-
5CDS-intronENST00000538136ENST00000434523MSH6chr2

48033764

-FBXO11chr2

48034059

-
5CDS-intronENST00000538136ENST00000434523MSH6chr2

48033781

+FBXO11chr2

48034071

-
5CDS-intronENST00000538136ENST00000434523MSH6chr2

48032786

-FBXO11chr2

48034069

-
5CDS-intronENST00000538136ENST00000434523MSH6chr2

48033753

+FBXO11chr2

48034069

-
5CDS-intronENST00000538136ENST00000434523MSH6chr2

48032766

-FBXO11chr2

48034076

-
5CDS-intronENST00000538136ENST00000434523MSH6chr2

48033706

-FBXO11chr2

48034058

-
5CDS-intronENST00000538136ENST00000480038MSH6chr2

48033764

-FBXO11chr2

48034059

-
5CDS-intronENST00000538136ENST00000480038MSH6chr2

48033781

+FBXO11chr2

48034071

-
5CDS-intronENST00000538136ENST00000480038MSH6chr2

48032786

-FBXO11chr2

48034069

-
5CDS-intronENST00000538136ENST00000480038MSH6chr2

48033753

+FBXO11chr2

48034069

-
5CDS-intronENST00000538136ENST00000480038MSH6chr2

48032766

-FBXO11chr2

48034076

-
5CDS-intronENST00000538136ENST00000480038MSH6chr2

48033706

-FBXO11chr2

48034058

-
5CDS-intronENST00000540021ENST00000316377MSH6chr2

48033764

-FBXO11chr2

48034059

-
5CDS-intronENST00000540021ENST00000316377MSH6chr2

48033706

-FBXO11chr2

48034058

-
5CDS-intronENST00000540021ENST00000378314MSH6chr2

48033764

-FBXO11chr2

48034059

-
5CDS-intronENST00000540021ENST00000378314MSH6chr2

48033781

+FBXO11chr2

48034071

-
5CDS-intronENST00000540021ENST00000378314MSH6chr2

48032786

-FBXO11chr2

48034069

-
5CDS-intronENST00000540021ENST00000378314MSH6chr2

48033753

+FBXO11chr2

48034069

-
5CDS-intronENST00000540021ENST00000378314MSH6chr2

48032766

-FBXO11chr2

48034076

-
5CDS-intronENST00000540021ENST00000378314MSH6chr2

48033706

-FBXO11chr2

48034058

-
5CDS-intronENST00000540021ENST00000402508MSH6chr2

48033764

-FBXO11chr2

48034059

-
5CDS-intronENST00000540021ENST00000402508MSH6chr2

48033706

-FBXO11chr2

48034058

-
5CDS-intronENST00000540021ENST00000403359MSH6chr2

48033764

-FBXO11chr2

48034059

-
5CDS-intronENST00000540021ENST00000403359MSH6chr2

48033706

-FBXO11chr2

48034058

-
5CDS-intronENST00000540021ENST00000405808MSH6chr2

48033764

-FBXO11chr2

48034059

-
5CDS-intronENST00000540021ENST00000405808MSH6chr2

48033781

+FBXO11chr2

48034071

-
5CDS-intronENST00000540021ENST00000405808MSH6chr2

48032786

-FBXO11chr2

48034069

-
5CDS-intronENST00000540021ENST00000405808MSH6chr2

48033753

+FBXO11chr2

48034069

-
5CDS-intronENST00000540021ENST00000405808MSH6chr2

48032766

-FBXO11chr2

48034076

-
5CDS-intronENST00000540021ENST00000405808MSH6chr2

48033706

-FBXO11chr2

48034058

-
5CDS-intronENST00000540021ENST00000434523MSH6chr2

48033764

-FBXO11chr2

48034059

-
5CDS-intronENST00000540021ENST00000434523MSH6chr2

48033781

+FBXO11chr2

48034071

-
5CDS-intronENST00000540021ENST00000434523MSH6chr2

48032786

-FBXO11chr2

48034069

-
5CDS-intronENST00000540021ENST00000434523MSH6chr2

48033753

+FBXO11chr2

48034069

-
5CDS-intronENST00000540021ENST00000434523MSH6chr2

48032766

-FBXO11chr2

48034076

-
5CDS-intronENST00000540021ENST00000434523MSH6chr2

48033706

-FBXO11chr2

48034058

-
5CDS-intronENST00000540021ENST00000480038MSH6chr2

48033764

-FBXO11chr2

48034059

-
5CDS-intronENST00000540021ENST00000480038MSH6chr2

48033781

+FBXO11chr2

48034071

-
5CDS-intronENST00000540021ENST00000480038MSH6chr2

48032786

-FBXO11chr2

48034069

-
5CDS-intronENST00000540021ENST00000480038MSH6chr2

48033753

+FBXO11chr2

48034069

-
5CDS-intronENST00000540021ENST00000480038MSH6chr2

48032766

-FBXO11chr2

48034076

-
5CDS-intronENST00000540021ENST00000480038MSH6chr2

48033706

-FBXO11chr2

48034058

-
intron-3UTRENST00000234420ENST00000316377MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-3UTRENST00000234420ENST00000402508MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-3UTRENST00000234420ENST00000403359MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-3UTRENST00000234420ENST00000434523MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-3UTRENST00000538136ENST00000316377MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-3UTRENST00000538136ENST00000402508MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-3UTRENST00000538136ENST00000403359MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-3UTRENST00000538136ENST00000434523MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-3UTRENST00000540021ENST00000316377MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-3UTRENST00000540021ENST00000402508MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-3UTRENST00000540021ENST00000403359MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-3UTRENST00000540021ENST00000434523MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-3UTRENST00000607272ENST00000316377MSH6chr2

48033781

+FBXO11chr2

48034071

-
intron-3UTRENST00000607272ENST00000316377MSH6chr2

48032786

-FBXO11chr2

48034069

-
intron-3UTRENST00000607272ENST00000316377MSH6chr2

48033753

+FBXO11chr2

48034069

-
intron-3UTRENST00000607272ENST00000316377MSH6chr2

48032766

-FBXO11chr2

48034076

-
intron-3UTRENST00000607272ENST00000316377MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-3UTRENST00000607272ENST00000402508MSH6chr2

48033781

+FBXO11chr2

48034071

-
intron-3UTRENST00000607272ENST00000402508MSH6chr2

48032786

-FBXO11chr2

48034069

-
intron-3UTRENST00000607272ENST00000402508MSH6chr2

48033753

+FBXO11chr2

48034069

-
intron-3UTRENST00000607272ENST00000402508MSH6chr2

48032766

-FBXO11chr2

48034076

-
intron-3UTRENST00000607272ENST00000402508MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-3UTRENST00000607272ENST00000403359MSH6chr2

48033781

+FBXO11chr2

48034071

-
intron-3UTRENST00000607272ENST00000403359MSH6chr2

48032786

-FBXO11chr2

48034069

-
intron-3UTRENST00000607272ENST00000403359MSH6chr2

48033753

+FBXO11chr2

48034069

-
intron-3UTRENST00000607272ENST00000403359MSH6chr2

48032766

-FBXO11chr2

48034076

-
intron-3UTRENST00000607272ENST00000403359MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-3UTRENST00000607272ENST00000434523MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-intronENST00000234420ENST00000378314MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-intronENST00000234420ENST00000405808MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-intronENST00000234420ENST00000480038MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-intronENST00000538136ENST00000378314MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-intronENST00000538136ENST00000405808MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-intronENST00000538136ENST00000480038MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-intronENST00000540021ENST00000378314MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-intronENST00000540021ENST00000405808MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-intronENST00000540021ENST00000480038MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-intronENST00000607272ENST00000316377MSH6chr2

48033764

-FBXO11chr2

48034059

-
intron-intronENST00000607272ENST00000316377MSH6chr2

48033706

-FBXO11chr2

48034058

-
intron-intronENST00000607272ENST00000378314MSH6chr2

48033764

-FBXO11chr2

48034059

-
intron-intronENST00000607272ENST00000378314MSH6chr2

48033781

+FBXO11chr2

48034071

-
intron-intronENST00000607272ENST00000378314MSH6chr2

48032786

-FBXO11chr2

48034069

-
intron-intronENST00000607272ENST00000378314MSH6chr2

48033753

+FBXO11chr2

48034069

-
intron-intronENST00000607272ENST00000378314MSH6chr2

48032766

-FBXO11chr2

48034076

-
intron-intronENST00000607272ENST00000378314MSH6chr2

48033706

-FBXO11chr2

48034058

-
intron-intronENST00000607272ENST00000378314MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-intronENST00000607272ENST00000402508MSH6chr2

48033764

-FBXO11chr2

48034059

-
intron-intronENST00000607272ENST00000402508MSH6chr2

48033706

-FBXO11chr2

48034058

-
intron-intronENST00000607272ENST00000403359MSH6chr2

48033764

-FBXO11chr2

48034059

-
intron-intronENST00000607272ENST00000403359MSH6chr2

48033706

-FBXO11chr2

48034058

-
intron-intronENST00000607272ENST00000405808MSH6chr2

48033764

-FBXO11chr2

48034059

-
intron-intronENST00000607272ENST00000405808MSH6chr2

48033781

+FBXO11chr2

48034071

-
intron-intronENST00000607272ENST00000405808MSH6chr2

48032786

-FBXO11chr2

48034069

-
intron-intronENST00000607272ENST00000405808MSH6chr2

48033753

+FBXO11chr2

48034069

-
intron-intronENST00000607272ENST00000405808MSH6chr2

48032766

-FBXO11chr2

48034076

-
intron-intronENST00000607272ENST00000405808MSH6chr2

48033706

-FBXO11chr2

48034058

-
intron-intronENST00000607272ENST00000405808MSH6chr2

48031135

-FBXO11chr2

48034721

-
intron-intronENST00000607272ENST00000434523MSH6chr2

48033764

-FBXO11chr2

48034059

-
intron-intronENST00000607272ENST00000434523MSH6chr2

48033781

+FBXO11chr2

48034071

-
intron-intronENST00000607272ENST00000434523MSH6chr2

48032786

-FBXO11chr2

48034069

-
intron-intronENST00000607272ENST00000434523MSH6chr2

48033753

+FBXO11chr2

48034069

-
intron-intronENST00000607272ENST00000434523MSH6chr2

48032766

-FBXO11chr2

48034076

-
intron-intronENST00000607272ENST00000434523MSH6chr2

48033706

-FBXO11chr2

48034058

-
intron-intronENST00000607272ENST00000480038MSH6chr2

48033764

-FBXO11chr2

48034059

-
intron-intronENST00000607272ENST00000480038MSH6chr2

48033781

+FBXO11chr2

48034071

-
intron-intronENST00000607272ENST00000480038MSH6chr2

48032786

-FBXO11chr2

48034069

-
intron-intronENST00000607272ENST00000480038MSH6chr2

48033753

+FBXO11chr2

48034069

-
intron-intronENST00000607272ENST00000480038MSH6chr2

48032766

-FBXO11chr2

48034076

-
intron-intronENST00000607272ENST00000480038MSH6chr2

48033706

-FBXO11chr2

48034058

-
intron-intronENST00000607272ENST00000480038MSH6chr2

48031135

-FBXO11chr2

48034721

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MSH6-FBXO11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MSH6-FBXO11


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:48033753/:48034069)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MSH6

P52701

FBXO11

Q86XK2

FUNCTION: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}.FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53. {ECO:0000269|PubMed:17098746, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23892434, ECO:0000269|PubMed:24613396}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MSH6-FBXO11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MSH6-FBXO11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MSH6-FBXO11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MSH6-FBXO11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource