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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MSI2-CISD3 (FusionGDB2 ID:55308)

Fusion Gene Summary for MSI2-CISD3

Fusion gene summary

Fusion gene information	Fusion gene name: MSI2-CISD3
	Fusion gene ID: 55308
		Hgene	Tgene
	Gene symbol	MSI2	CISD3
	Gene ID	124540	284106
	Gene name	musashi RNA binding protein 2	CDGSH iron sulfur domain 3
	Synonyms	MSI2H	MiNT\|Miner2
	Cytomap	17q22	17q12
	Type of gene	protein-coding	protein-coding
	Description	RNA-binding protein Musashi homolog 2musashi homolog 2musashi-2	CDGSH iron-sulfur domain-containing protein 3, mitochondrialmitoNEET related 2mitoNEET-related protein 2mitochondrial inner NEET protein
	Modification date	20200313	20200313
	UniProtAcc	.	P0C7P0
	Ensembl transtripts involved in fusion gene	ENST00000284073, ENST00000322684, ENST00000416426, ENST00000442934, ENST00000579180, ENST00000579505,	ENST00000578573, ENST00000439660,
Fusion gene scores	* DoF score	40 X 16 X 16=10240	8 X 6 X 5=240
	# samples	45	10
	** MAII score	log2(45/10240*10)=-4.50814690367033 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/240*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MSI2 [Title/Abstract] AND CISD3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MSI2(55478832)-CISD3(36887013), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CISD3	GO:0106034	protein maturation by [2Fe-2S] cluster transfer	29259115

Fusion gene breakpoints across MSI2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CISD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCS	TCGA-N8-A4PL-01A	MSI2	chr17	55478832	-	CISD3	chr17	36887013	+
ChimerDB4	UCS	TCGA-N8-A4PL-01A	MSI2	chr17	55478832	+	CISD3	chr17	36887013	+
ChimerDB4	UCS	TCGA-N8-A4PL	MSI2	chr17	55478832	+	CISD3	chr17	36887012	+
ChimerDB4	UCS	TCGA-N8-A4PL	MSI2	chr17	55478832	+	CISD3	chr17	36887013	+

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Fusion Gene ORF analysis for MSI2-CISD3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000284073	ENST00000578573	MSI2	chr17	55478832	+	CISD3	chr17	36887013	+
5CDS-3UTR	ENST00000284073	ENST00000578573	MSI2	chr17	55478832	+	CISD3	chr17	36887012	+
5CDS-3UTR	ENST00000322684	ENST00000578573	MSI2	chr17	55478832	+	CISD3	chr17	36887013	+
5CDS-3UTR	ENST00000322684	ENST00000578573	MSI2	chr17	55478832	+	CISD3	chr17	36887012	+
5CDS-3UTR	ENST00000416426	ENST00000578573	MSI2	chr17	55478832	+	CISD3	chr17	36887013	+
5CDS-3UTR	ENST00000416426	ENST00000578573	MSI2	chr17	55478832	+	CISD3	chr17	36887012	+
5CDS-3UTR	ENST00000442934	ENST00000578573	MSI2	chr17	55478832	+	CISD3	chr17	36887013	+
5CDS-3UTR	ENST00000442934	ENST00000578573	MSI2	chr17	55478832	+	CISD3	chr17	36887012	+
5CDS-3UTR	ENST00000579180	ENST00000578573	MSI2	chr17	55478832	+	CISD3	chr17	36887013	+
5CDS-3UTR	ENST00000579180	ENST00000578573	MSI2	chr17	55478832	+	CISD3	chr17	36887012	+
In-frame	ENST00000284073	ENST00000439660	MSI2	chr17	55478832	+	CISD3	chr17	36887013	+
In-frame	ENST00000284073	ENST00000439660	MSI2	chr17	55478832	+	CISD3	chr17	36887012	+
In-frame	ENST00000322684	ENST00000439660	MSI2	chr17	55478832	+	CISD3	chr17	36887013	+
In-frame	ENST00000322684	ENST00000439660	MSI2	chr17	55478832	+	CISD3	chr17	36887012	+
In-frame	ENST00000416426	ENST00000439660	MSI2	chr17	55478832	+	CISD3	chr17	36887013	+
In-frame	ENST00000416426	ENST00000439660	MSI2	chr17	55478832	+	CISD3	chr17	36887012	+
In-frame	ENST00000442934	ENST00000439660	MSI2	chr17	55478832	+	CISD3	chr17	36887013	+
In-frame	ENST00000442934	ENST00000439660	MSI2	chr17	55478832	+	CISD3	chr17	36887012	+
In-frame	ENST00000579180	ENST00000439660	MSI2	chr17	55478832	+	CISD3	chr17	36887013	+
In-frame	ENST00000579180	ENST00000439660	MSI2	chr17	55478832	+	CISD3	chr17	36887012	+
intron-3CDS	ENST00000579505	ENST00000439660	MSI2	chr17	55478832	+	CISD3	chr17	36887013	+
intron-3CDS	ENST00000579505	ENST00000439660	MSI2	chr17	55478832	+	CISD3	chr17	36887012	+
intron-3UTR	ENST00000579505	ENST00000578573	MSI2	chr17	55478832	+	CISD3	chr17	36887013	+
intron-3UTR	ENST00000579505	ENST00000578573	MSI2	chr17	55478832	+	CISD3	chr17	36887012	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000416426	MSI2	chr17	55478832	+	ENST00000439660	CISD3	chr17	36887013	+	2376	474	93	809	238
ENST00000284073	MSI2	chr17	55478832	+	ENST00000439660	CISD3	chr17	36887013	+	2516	614	179	949	256
ENST00000322684	MSI2	chr17	55478832	+	ENST00000439660	CISD3	chr17	36887013	+	2330	428	35	763	242
ENST00000442934	MSI2	chr17	55478832	+	ENST00000439660	CISD3	chr17	36887013	+	2164	262	40	597	185
ENST00000579180	MSI2	chr17	55478832	+	ENST00000439660	CISD3	chr17	36887013	+	2100	198	105	533	142
ENST00000416426	MSI2	chr17	55478832	+	ENST00000439660	CISD3	chr17	36887012	+	2376	474	93	809	238
ENST00000284073	MSI2	chr17	55478832	+	ENST00000439660	CISD3	chr17	36887012	+	2516	614	179	949	256
ENST00000322684	MSI2	chr17	55478832	+	ENST00000439660	CISD3	chr17	36887012	+	2330	428	35	763	242
ENST00000442934	MSI2	chr17	55478832	+	ENST00000439660	CISD3	chr17	36887012	+	2164	262	40	597	185
ENST00000579180	MSI2	chr17	55478832	+	ENST00000439660	CISD3	chr17	36887012	+	2100	198	105	533	142

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000416426	ENST00000439660	MSI2	chr17	55478832	+	CISD3	chr17	36887013	+	0.06248564	0.9375144
ENST00000284073	ENST00000439660	MSI2	chr17	55478832	+	CISD3	chr17	36887013	+	0.086354434	0.9136456
ENST00000322684	ENST00000439660	MSI2	chr17	55478832	+	CISD3	chr17	36887013	+	0.0488184	0.95118165
ENST00000442934	ENST00000439660	MSI2	chr17	55478832	+	CISD3	chr17	36887013	+	0.06980632	0.9301937
ENST00000579180	ENST00000439660	MSI2	chr17	55478832	+	CISD3	chr17	36887013	+	0.41777393	0.5822261
ENST00000416426	ENST00000439660	MSI2	chr17	55478832	+	CISD3	chr17	36887012	+	0.06248564	0.9375144
ENST00000284073	ENST00000439660	MSI2	chr17	55478832	+	CISD3	chr17	36887012	+	0.086354434	0.9136456
ENST00000322684	ENST00000439660	MSI2	chr17	55478832	+	CISD3	chr17	36887012	+	0.0488184	0.95118165
ENST00000442934	ENST00000439660	MSI2	chr17	55478832	+	CISD3	chr17	36887012	+	0.06980632	0.9301937
ENST00000579180	ENST00000439660	MSI2	chr17	55478832	+	CISD3	chr17	36887012	+	0.41777393	0.5822261

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Fusion Genomic Features for MSI2-CISD3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MSI2-CISD3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:55478832/chr17:36887013)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CISD3 P0C7P0
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2. Contributes to mitochondrial iron homeostasis and in maintaining normal levels of free iron and reactive oxygen species, and thereby contributes to normal mitochondrial function. {ECO:0000269\|PubMed:29259115}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MSI2

chr17:55478832

chr17:36887012

ENST00000284073

21_111

135

1951.0

Domain

RRM 1

Hgene

MSI2

chr17:55478832

chr17:36887012

ENST00000322684

21_111

131

252.0

Domain

RRM 1

Hgene

MSI2

chr17:55478832

chr17:36887013

ENST00000284073

21_111

135

1951.0

Domain

RRM 1

Hgene

MSI2

chr17:55478832

chr17:36887013

ENST00000322684

21_111

131

252.0

Domain

RRM 1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MSI2

chr17:55478832

chr17:36887012

ENST00000284073

253_260

135

1951.0

Compositional bias

Note=Poly-Ala

Hgene

MSI2

chr17:55478832

chr17:36887012

ENST00000322684

253_260

131

252.0

Compositional bias

Note=Poly-Ala

Hgene

MSI2

chr17:55478832

chr17:36887012

ENST00000579180

253_260

152.0

Compositional bias

Note=Poly-Ala

Hgene

MSI2

chr17:55478832

chr17:36887013

ENST00000284073

253_260

135

1951.0

Compositional bias

Note=Poly-Ala

Hgene

MSI2

chr17:55478832

chr17:36887013

ENST00000322684

253_260

131

252.0

Compositional bias

Note=Poly-Ala

Hgene

MSI2

chr17:55478832

chr17:36887013

ENST00000579180

253_260

152.0

Compositional bias

Note=Poly-Ala

Hgene

MSI2

chr17:55478832

chr17:36887012

ENST00000284073

110_187

135

1951.0

Domain

RRM 2

Hgene

MSI2

chr17:55478832

chr17:36887012

ENST00000322684

110_187

131

252.0

Domain

RRM 2

Hgene

MSI2

chr17:55478832

chr17:36887012

ENST00000579180

110_187

152.0

Domain

RRM 2

Hgene

MSI2

chr17:55478832

chr17:36887012

ENST00000579180

21_111

152.0

Domain

RRM 1

Hgene

MSI2

chr17:55478832

chr17:36887013

ENST00000284073

110_187

135

1951.0

Domain

RRM 2

Hgene

MSI2

chr17:55478832

chr17:36887013

ENST00000322684

110_187

131

252.0

Domain

RRM 2

Hgene

MSI2

chr17:55478832

chr17:36887013

ENST00000579180

110_187

152.0

Domain

RRM 2

Hgene

MSI2

chr17:55478832

chr17:36887013

ENST00000579180

21_111

152.0

Domain

RRM 1

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Fusion Gene Sequence for MSI2-CISD3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>55308_55308_1_MSI2-CISD3_MSI2_chr17_55478832_ENST00000284073_CISD3_chr17_36887012_ENST00000439660_length(transcript)=2516nt_BP=614nt
CGGGGCTGAGCTAAGCCGAGCCCACGTGTGACGGCTCTCGCCGCTGCCCCGGCTCCGCCGCTCGCAGAGAGATTCGGAGGAGCCCGGGCG
GGGGGGAGGAGGAGGGGGAGGAGGGAGCGGAGATCTCGGGGCTCGGAGCCGGCCGCCGCTCCGCTCCGATCGCTGTGGGGCTTGGTTTTT
TGGGGGTGGGGGGGCGGGGGGGCTCAGATATGGAGGCAAATGGGAGCCAAGGCACCTCGGGCAGCGCCAACGACTCCCAGCACGACCCCG
GTAAAATGTTTATCGGTGGACTGAGCTGGCAGACCTCACCAGATAGCCTTAGAGACTATTTTAGCAAATTTGGAGAAATTAGAGAATGTA
TGGTCATGAGAGATCCCACTACGAAACGCTCCAGAGGCTTCGGTTTCGTCACGTTCGCAGACCCAGCAAGTGTAGATAAAGTATTAGGTC
AGCCCCACCATGAGTTAGATTCCAAGACGATTGACCCCAAAGTTGCATTTCCTCGTCGAGCGCAACCCAAGATGGTCACAAGAACAAAGA
AAATATTTGTAGGCGGGTTATCTGCGAACACAGTAGTGGAAGATGTAAAGCAATATTTCGAGCAGTTTGGCAAGGACCTGAACCCGCGGC
GGGACATCTCCTCCTGGCTGGCCCAGTGGTTCCCTAGAACCCCAGCCAGGTCCGTGGTGGCCCTGAAGACCCCCATCAAGGTGGAGCTGG
TGGCAGGGAAAACCTACAGGTGGTGTGTGTGTGGCCGCAGCAAGAAGCAGCCCTTCTGTGACGGCTCCCACTTCTTCCAACGCACTGGCC
TATCTCCACTCAAGTTCAAGGCCCAAGAGACCCGCATGGTGGCACTCTGTACCTGCAAGGCCACTCAGAGGCCCCCGTACTGCGATGGCA
CCCACAGGAGTGAGCGCGTGCAGAAGGCAGAAGTGGGCTCCCCACTCTGAGGGGGCTGCTGCTGTCCAGCCACAGGTGGCCTTGGCTCCA
GGCCTCTGACAGGCACCCCCTTCTGTGGGAAAGGAAACAGGTGCTGAGCCCAAGAGACTCTGGTACCCACTGCTGGCTCATGAAGGAAGA
ATTATTCCTTATAACCTAAAAGTCTCCAGTCTGGGGCAGGCGGGAGTGGGCCCTGGTTCAATGTTTGCTGATGGGGAAGATGGCAAAAAC
AAGCCTGCCCAACCAGACTGGTAGTCCTGCAGTCACTGCTATGAGGCCCACGTGCTGCCTCCTGCTCCAGATTTTAACCTCTCTGTGGGC
TGGGGGCACCTGACCAGCCACAGGAGAGGGCAGTTCAGATTCATTCTGTATGGGGTCCCCAAGCCAGGCTAAACCCAGAGATGAGAGGCA
CCCTTCCCTTCTTCCCTCCACCCCAAAGAACTACAGGCTCCAGAAAGTATGCAGCATTTATTACAAAGCCAAGAGATACAGATGTCCCAG
GGCAAAGGAGGGTACAGTCACAGGACCTCAGACACAGGACAAGGTGCAAACACAGACAAGCCCATCAGGGGGCTCCCAACCCCACACACC
TACGCTATGATGGAATCTCGAGTCTCGACTCCCGACTCCTCTCAGATCTATGCACACTTGAGGAAATCTCGGTGGGCAGCGACCTGCCAG
GGTCTGTCCCTAAGGAGGTGGTCCGCTGACCTCTCAAGGGGTGGGGGTGGGGTCAGAGCTTACAGGTTTCTGTCTTCTTGTGCTTTTAGA
TGCAGTTGCTCTGTCCTGACCAGGTGACCGGGCCTCAGCTGGGGGTGGAGGGGCAATTGGAAGGCTGTTTGCCTCTGGCAAAGTCTGGGA
TCTGTGCTTGTGTGAGGTTAACCCACCCCCACTTCCACTCTAGGCCCCAGGTGAGACTCCACCACCAGTCCTGCTAGTGAGGGTTCCCCG
GTGAGGGTAAGGTTGGTGGGGGTGCAGCGCTTCACAATGCTAAAGCCTTAGCCCTCCTCCAAGAGCTGAGACCTCTCAGGGCCTGAATCT
TCTTTTCCACAAGATAAATGATGCAAAGGCCACACACACAGGAAAAAAAAAAAAAGAGGCAGAACTATCTATTCTTTGCACAAAGTTTCC
ACTGCAAGAGGAGGAGGTGATGCAGGTGCCACCTCCACCCTGCACTTGCTCCTCAGAACCAGGGATAAACTGCATTTGTAAAAGGCACTG
TTCTTAGCAATTTCTGGACATTCAACAACGTGGGGGGCGGCCACTGGTCAGAGGCAGGACAGCAGCCAAGATGGGGAGAGAAACGGGGAG
AGAAAGAAACGATTCTAACTGACTCCTATATGCAGCCAGTTGGAATCATGCCTAAAGCTTTGGGTCTGAAGGGGCCCCCAACACACCACC
TGCCTTGGGAAACAGCGAGGATGGTGCAGAGCTTTATTGAGACTCCAGTGGCCCATCCAGTTCATCTCCAGGCACCCCCAAAAACAGCAA

>55308_55308_1_MSI2-CISD3_MSI2_chr17_55478832_ENST00000284073_CISD3_chr17_36887012_ENST00000439660_length(amino acids)=256AA_BP=145
MGVGGRGGSDMEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLG
QPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKDLNPRRDISSWLAQWFPRTPARSVVALKTPIKVEL

--------------------------------------------------------------
>55308_55308_2_MSI2-CISD3_MSI2_chr17_55478832_ENST00000284073_CISD3_chr17_36887013_ENST00000439660_length(transcript)=2516nt_BP=614nt
CGGGGCTGAGCTAAGCCGAGCCCACGTGTGACGGCTCTCGCCGCTGCCCCGGCTCCGCCGCTCGCAGAGAGATTCGGAGGAGCCCGGGCG
GGGGGGAGGAGGAGGGGGAGGAGGGAGCGGAGATCTCGGGGCTCGGAGCCGGCCGCCGCTCCGCTCCGATCGCTGTGGGGCTTGGTTTTT
TGGGGGTGGGGGGGCGGGGGGGCTCAGATATGGAGGCAAATGGGAGCCAAGGCACCTCGGGCAGCGCCAACGACTCCCAGCACGACCCCG
GTAAAATGTTTATCGGTGGACTGAGCTGGCAGACCTCACCAGATAGCCTTAGAGACTATTTTAGCAAATTTGGAGAAATTAGAGAATGTA
TGGTCATGAGAGATCCCACTACGAAACGCTCCAGAGGCTTCGGTTTCGTCACGTTCGCAGACCCAGCAAGTGTAGATAAAGTATTAGGTC
AGCCCCACCATGAGTTAGATTCCAAGACGATTGACCCCAAAGTTGCATTTCCTCGTCGAGCGCAACCCAAGATGGTCACAAGAACAAAGA
AAATATTTGTAGGCGGGTTATCTGCGAACACAGTAGTGGAAGATGTAAAGCAATATTTCGAGCAGTTTGGCAAGGACCTGAACCCGCGGC
GGGACATCTCCTCCTGGCTGGCCCAGTGGTTCCCTAGAACCCCAGCCAGGTCCGTGGTGGCCCTGAAGACCCCCATCAAGGTGGAGCTGG
TGGCAGGGAAAACCTACAGGTGGTGTGTGTGTGGCCGCAGCAAGAAGCAGCCCTTCTGTGACGGCTCCCACTTCTTCCAACGCACTGGCC
TATCTCCACTCAAGTTCAAGGCCCAAGAGACCCGCATGGTGGCACTCTGTACCTGCAAGGCCACTCAGAGGCCCCCGTACTGCGATGGCA
CCCACAGGAGTGAGCGCGTGCAGAAGGCAGAAGTGGGCTCCCCACTCTGAGGGGGCTGCTGCTGTCCAGCCACAGGTGGCCTTGGCTCCA
GGCCTCTGACAGGCACCCCCTTCTGTGGGAAAGGAAACAGGTGCTGAGCCCAAGAGACTCTGGTACCCACTGCTGGCTCATGAAGGAAGA
ATTATTCCTTATAACCTAAAAGTCTCCAGTCTGGGGCAGGCGGGAGTGGGCCCTGGTTCAATGTTTGCTGATGGGGAAGATGGCAAAAAC
AAGCCTGCCCAACCAGACTGGTAGTCCTGCAGTCACTGCTATGAGGCCCACGTGCTGCCTCCTGCTCCAGATTTTAACCTCTCTGTGGGC
TGGGGGCACCTGACCAGCCACAGGAGAGGGCAGTTCAGATTCATTCTGTATGGGGTCCCCAAGCCAGGCTAAACCCAGAGATGAGAGGCA
CCCTTCCCTTCTTCCCTCCACCCCAAAGAACTACAGGCTCCAGAAAGTATGCAGCATTTATTACAAAGCCAAGAGATACAGATGTCCCAG
GGCAAAGGAGGGTACAGTCACAGGACCTCAGACACAGGACAAGGTGCAAACACAGACAAGCCCATCAGGGGGCTCCCAACCCCACACACC
TACGCTATGATGGAATCTCGAGTCTCGACTCCCGACTCCTCTCAGATCTATGCACACTTGAGGAAATCTCGGTGGGCAGCGACCTGCCAG
GGTCTGTCCCTAAGGAGGTGGTCCGCTGACCTCTCAAGGGGTGGGGGTGGGGTCAGAGCTTACAGGTTTCTGTCTTCTTGTGCTTTTAGA
TGCAGTTGCTCTGTCCTGACCAGGTGACCGGGCCTCAGCTGGGGGTGGAGGGGCAATTGGAAGGCTGTTTGCCTCTGGCAAAGTCTGGGA
TCTGTGCTTGTGTGAGGTTAACCCACCCCCACTTCCACTCTAGGCCCCAGGTGAGACTCCACCACCAGTCCTGCTAGTGAGGGTTCCCCG
GTGAGGGTAAGGTTGGTGGGGGTGCAGCGCTTCACAATGCTAAAGCCTTAGCCCTCCTCCAAGAGCTGAGACCTCTCAGGGCCTGAATCT
TCTTTTCCACAAGATAAATGATGCAAAGGCCACACACACAGGAAAAAAAAAAAAAGAGGCAGAACTATCTATTCTTTGCACAAAGTTTCC
ACTGCAAGAGGAGGAGGTGATGCAGGTGCCACCTCCACCCTGCACTTGCTCCTCAGAACCAGGGATAAACTGCATTTGTAAAAGGCACTG
TTCTTAGCAATTTCTGGACATTCAACAACGTGGGGGGCGGCCACTGGTCAGAGGCAGGACAGCAGCCAAGATGGGGAGAGAAACGGGGAG
AGAAAGAAACGATTCTAACTGACTCCTATATGCAGCCAGTTGGAATCATGCCTAAAGCTTTGGGTCTGAAGGGGCCCCCAACACACCACC
TGCCTTGGGAAACAGCGAGGATGGTGCAGAGCTTTATTGAGACTCCAGTGGCCCATCCAGTTCATCTCCAGGCACCCCCAAAAACAGCAA

>55308_55308_2_MSI2-CISD3_MSI2_chr17_55478832_ENST00000284073_CISD3_chr17_36887013_ENST00000439660_length(amino acids)=256AA_BP=145
MGVGGRGGSDMEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLG
QPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKDLNPRRDISSWLAQWFPRTPARSVVALKTPIKVEL

--------------------------------------------------------------
>55308_55308_3_MSI2-CISD3_MSI2_chr17_55478832_ENST00000322684_CISD3_chr17_36887012_ENST00000439660_length(transcript)=2330nt_BP=428nt
GCTTTCCTTTTAGCTTTTGTAAGTTACACGTCAAAATGGCCGATCTGACATCGGTGCTCACTTCTGTTATGTTTTCTCCCTCTAGTAAAA
TGTTTATCGGTGGACTGAGCTGGCAGACCTCACCAGATAGCCTTAGAGACTATTTTAGCAAATTTGGAGAAATTAGAGAATGTATGGTCA
TGAGAGATCCCACTACGAAACGCTCCAGAGGCTTCGGTTTCGTCACGTTCGCAGACCCAGCAAGTGTAGATAAAGTATTAGGTCAGCCCC
ACCATGAGTTAGATTCCAAGACGATTGACCCCAAAGTTGCATTTCCTCGTCGAGCGCAACCCAAGATGGTCACAAGAACAAAGAAAATAT
TTGTAGGCGGGTTATCTGCGAACACAGTAGTGGAAGATGTAAAGCAATATTTCGAGCAGTTTGGCAAGGACCTGAACCCGCGGCGGGACA
TCTCCTCCTGGCTGGCCCAGTGGTTCCCTAGAACCCCAGCCAGGTCCGTGGTGGCCCTGAAGACCCCCATCAAGGTGGAGCTGGTGGCAG
GGAAAACCTACAGGTGGTGTGTGTGTGGCCGCAGCAAGAAGCAGCCCTTCTGTGACGGCTCCCACTTCTTCCAACGCACTGGCCTATCTC
CACTCAAGTTCAAGGCCCAAGAGACCCGCATGGTGGCACTCTGTACCTGCAAGGCCACTCAGAGGCCCCCGTACTGCGATGGCACCCACA
GGAGTGAGCGCGTGCAGAAGGCAGAAGTGGGCTCCCCACTCTGAGGGGGCTGCTGCTGTCCAGCCACAGGTGGCCTTGGCTCCAGGCCTC
TGACAGGCACCCCCTTCTGTGGGAAAGGAAACAGGTGCTGAGCCCAAGAGACTCTGGTACCCACTGCTGGCTCATGAAGGAAGAATTATT
CCTTATAACCTAAAAGTCTCCAGTCTGGGGCAGGCGGGAGTGGGCCCTGGTTCAATGTTTGCTGATGGGGAAGATGGCAAAAACAAGCCT
GCCCAACCAGACTGGTAGTCCTGCAGTCACTGCTATGAGGCCCACGTGCTGCCTCCTGCTCCAGATTTTAACCTCTCTGTGGGCTGGGGG
CACCTGACCAGCCACAGGAGAGGGCAGTTCAGATTCATTCTGTATGGGGTCCCCAAGCCAGGCTAAACCCAGAGATGAGAGGCACCCTTC
CCTTCTTCCCTCCACCCCAAAGAACTACAGGCTCCAGAAAGTATGCAGCATTTATTACAAAGCCAAGAGATACAGATGTCCCAGGGCAAA
GGAGGGTACAGTCACAGGACCTCAGACACAGGACAAGGTGCAAACACAGACAAGCCCATCAGGGGGCTCCCAACCCCACACACCTACGCT
ATGATGGAATCTCGAGTCTCGACTCCCGACTCCTCTCAGATCTATGCACACTTGAGGAAATCTCGGTGGGCAGCGACCTGCCAGGGTCTG
TCCCTAAGGAGGTGGTCCGCTGACCTCTCAAGGGGTGGGGGTGGGGTCAGAGCTTACAGGTTTCTGTCTTCTTGTGCTTTTAGATGCAGT
TGCTCTGTCCTGACCAGGTGACCGGGCCTCAGCTGGGGGTGGAGGGGCAATTGGAAGGCTGTTTGCCTCTGGCAAAGTCTGGGATCTGTG
CTTGTGTGAGGTTAACCCACCCCCACTTCCACTCTAGGCCCCAGGTGAGACTCCACCACCAGTCCTGCTAGTGAGGGTTCCCCGGTGAGG
GTAAGGTTGGTGGGGGTGCAGCGCTTCACAATGCTAAAGCCTTAGCCCTCCTCCAAGAGCTGAGACCTCTCAGGGCCTGAATCTTCTTTT
CCACAAGATAAATGATGCAAAGGCCACACACACAGGAAAAAAAAAAAAAGAGGCAGAACTATCTATTCTTTGCACAAAGTTTCCACTGCA
AGAGGAGGAGGTGATGCAGGTGCCACCTCCACCCTGCACTTGCTCCTCAGAACCAGGGATAAACTGCATTTGTAAAAGGCACTGTTCTTA
GCAATTTCTGGACATTCAACAACGTGGGGGGCGGCCACTGGTCAGAGGCAGGACAGCAGCCAAGATGGGGAGAGAAACGGGGAGAGAAAG
AAACGATTCTAACTGACTCCTATATGCAGCCAGTTGGAATCATGCCTAAAGCTTTGGGTCTGAAGGGGCCCCCAACACACCACCTGCCTT
GGGAAACAGCGAGGATGGTGCAGAGCTTTATTGAGACTCCAGTGGCCCATCCAGTTCATCTCCAGGCACCCCCAAAAACAGCAAATTACA

>55308_55308_3_MSI2-CISD3_MSI2_chr17_55478832_ENST00000322684_CISD3_chr17_36887012_ENST00000439660_length(amino acids)=242AA_BP=131
MADLTSVLTSVMFSPSSKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPK
VAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKDLNPRRDISSWLAQWFPRTPARSVVALKTPIKVELVAGKTYRWCVCGRS

--------------------------------------------------------------
>55308_55308_4_MSI2-CISD3_MSI2_chr17_55478832_ENST00000322684_CISD3_chr17_36887013_ENST00000439660_length(transcript)=2330nt_BP=428nt
GCTTTCCTTTTAGCTTTTGTAAGTTACACGTCAAAATGGCCGATCTGACATCGGTGCTCACTTCTGTTATGTTTTCTCCCTCTAGTAAAA
TGTTTATCGGTGGACTGAGCTGGCAGACCTCACCAGATAGCCTTAGAGACTATTTTAGCAAATTTGGAGAAATTAGAGAATGTATGGTCA
TGAGAGATCCCACTACGAAACGCTCCAGAGGCTTCGGTTTCGTCACGTTCGCAGACCCAGCAAGTGTAGATAAAGTATTAGGTCAGCCCC
ACCATGAGTTAGATTCCAAGACGATTGACCCCAAAGTTGCATTTCCTCGTCGAGCGCAACCCAAGATGGTCACAAGAACAAAGAAAATAT
TTGTAGGCGGGTTATCTGCGAACACAGTAGTGGAAGATGTAAAGCAATATTTCGAGCAGTTTGGCAAGGACCTGAACCCGCGGCGGGACA
TCTCCTCCTGGCTGGCCCAGTGGTTCCCTAGAACCCCAGCCAGGTCCGTGGTGGCCCTGAAGACCCCCATCAAGGTGGAGCTGGTGGCAG
GGAAAACCTACAGGTGGTGTGTGTGTGGCCGCAGCAAGAAGCAGCCCTTCTGTGACGGCTCCCACTTCTTCCAACGCACTGGCCTATCTC
CACTCAAGTTCAAGGCCCAAGAGACCCGCATGGTGGCACTCTGTACCTGCAAGGCCACTCAGAGGCCCCCGTACTGCGATGGCACCCACA
GGAGTGAGCGCGTGCAGAAGGCAGAAGTGGGCTCCCCACTCTGAGGGGGCTGCTGCTGTCCAGCCACAGGTGGCCTTGGCTCCAGGCCTC
TGACAGGCACCCCCTTCTGTGGGAAAGGAAACAGGTGCTGAGCCCAAGAGACTCTGGTACCCACTGCTGGCTCATGAAGGAAGAATTATT
CCTTATAACCTAAAAGTCTCCAGTCTGGGGCAGGCGGGAGTGGGCCCTGGTTCAATGTTTGCTGATGGGGAAGATGGCAAAAACAAGCCT
GCCCAACCAGACTGGTAGTCCTGCAGTCACTGCTATGAGGCCCACGTGCTGCCTCCTGCTCCAGATTTTAACCTCTCTGTGGGCTGGGGG
CACCTGACCAGCCACAGGAGAGGGCAGTTCAGATTCATTCTGTATGGGGTCCCCAAGCCAGGCTAAACCCAGAGATGAGAGGCACCCTTC
CCTTCTTCCCTCCACCCCAAAGAACTACAGGCTCCAGAAAGTATGCAGCATTTATTACAAAGCCAAGAGATACAGATGTCCCAGGGCAAA
GGAGGGTACAGTCACAGGACCTCAGACACAGGACAAGGTGCAAACACAGACAAGCCCATCAGGGGGCTCCCAACCCCACACACCTACGCT
ATGATGGAATCTCGAGTCTCGACTCCCGACTCCTCTCAGATCTATGCACACTTGAGGAAATCTCGGTGGGCAGCGACCTGCCAGGGTCTG
TCCCTAAGGAGGTGGTCCGCTGACCTCTCAAGGGGTGGGGGTGGGGTCAGAGCTTACAGGTTTCTGTCTTCTTGTGCTTTTAGATGCAGT
TGCTCTGTCCTGACCAGGTGACCGGGCCTCAGCTGGGGGTGGAGGGGCAATTGGAAGGCTGTTTGCCTCTGGCAAAGTCTGGGATCTGTG
CTTGTGTGAGGTTAACCCACCCCCACTTCCACTCTAGGCCCCAGGTGAGACTCCACCACCAGTCCTGCTAGTGAGGGTTCCCCGGTGAGG
GTAAGGTTGGTGGGGGTGCAGCGCTTCACAATGCTAAAGCCTTAGCCCTCCTCCAAGAGCTGAGACCTCTCAGGGCCTGAATCTTCTTTT
CCACAAGATAAATGATGCAAAGGCCACACACACAGGAAAAAAAAAAAAAGAGGCAGAACTATCTATTCTTTGCACAAAGTTTCCACTGCA
AGAGGAGGAGGTGATGCAGGTGCCACCTCCACCCTGCACTTGCTCCTCAGAACCAGGGATAAACTGCATTTGTAAAAGGCACTGTTCTTA
GCAATTTCTGGACATTCAACAACGTGGGGGGCGGCCACTGGTCAGAGGCAGGACAGCAGCCAAGATGGGGAGAGAAACGGGGAGAGAAAG
AAACGATTCTAACTGACTCCTATATGCAGCCAGTTGGAATCATGCCTAAAGCTTTGGGTCTGAAGGGGCCCCCAACACACCACCTGCCTT
GGGAAACAGCGAGGATGGTGCAGAGCTTTATTGAGACTCCAGTGGCCCATCCAGTTCATCTCCAGGCACCCCCAAAAACAGCAAATTACA

>55308_55308_4_MSI2-CISD3_MSI2_chr17_55478832_ENST00000322684_CISD3_chr17_36887013_ENST00000439660_length(amino acids)=242AA_BP=131
MADLTSVLTSVMFSPSSKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPK
VAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKDLNPRRDISSWLAQWFPRTPARSVVALKTPIKVELVAGKTYRWCVCGRS

--------------------------------------------------------------
>55308_55308_5_MSI2-CISD3_MSI2_chr17_55478832_ENST00000416426_CISD3_chr17_36887012_ENST00000439660_length(transcript)=2376nt_BP=474nt
AGAGCCAGAGAGAACTTCCAGCGCAAAAGGAAAATAAAACTTGTGGCTGGTGTTTGTGCAGGAGGGTCTCCGCCATCCTGAAGCCCCCCG
ATCCTGGGGCGTCTCGGGGGCCGCCAAAGGAGCGCCAGGGTTAAAATGTTTATCGGTGGACTGAGCTGGCAGACCTCACCAGATAGCCTT
AGAGACTATTTTAGCAAATTTGGAGAAATTAGAGAATGTATGGTCATGAGAGATCCCACTACGAAACGCTCCAGAGGCTTCGGTTTCGTC
ACGTTCGCAGACCCAGCAAGTGTAGATAAAGTATTAGGTCAGCCCCACCATGAGTTAGATTCCAAGACGATTGACCCCAAAGTTGCATTT
CCTCGTCGAGCGCAACCCAAGATGGTCACAAGAACAAAGAAAATATTTGTAGGCGGGTTATCTGCGAACACAGTAGTGGAAGATGTAAAG
CAATATTTCGAGCAGTTTGGCAAGGACCTGAACCCGCGGCGGGACATCTCCTCCTGGCTGGCCCAGTGGTTCCCTAGAACCCCAGCCAGG
TCCGTGGTGGCCCTGAAGACCCCCATCAAGGTGGAGCTGGTGGCAGGGAAAACCTACAGGTGGTGTGTGTGTGGCCGCAGCAAGAAGCAG
CCCTTCTGTGACGGCTCCCACTTCTTCCAACGCACTGGCCTATCTCCACTCAAGTTCAAGGCCCAAGAGACCCGCATGGTGGCACTCTGT
ACCTGCAAGGCCACTCAGAGGCCCCCGTACTGCGATGGCACCCACAGGAGTGAGCGCGTGCAGAAGGCAGAAGTGGGCTCCCCACTCTGA
GGGGGCTGCTGCTGTCCAGCCACAGGTGGCCTTGGCTCCAGGCCTCTGACAGGCACCCCCTTCTGTGGGAAAGGAAACAGGTGCTGAGCC
CAAGAGACTCTGGTACCCACTGCTGGCTCATGAAGGAAGAATTATTCCTTATAACCTAAAAGTCTCCAGTCTGGGGCAGGCGGGAGTGGG
CCCTGGTTCAATGTTTGCTGATGGGGAAGATGGCAAAAACAAGCCTGCCCAACCAGACTGGTAGTCCTGCAGTCACTGCTATGAGGCCCA
CGTGCTGCCTCCTGCTCCAGATTTTAACCTCTCTGTGGGCTGGGGGCACCTGACCAGCCACAGGAGAGGGCAGTTCAGATTCATTCTGTA
TGGGGTCCCCAAGCCAGGCTAAACCCAGAGATGAGAGGCACCCTTCCCTTCTTCCCTCCACCCCAAAGAACTACAGGCTCCAGAAAGTAT
GCAGCATTTATTACAAAGCCAAGAGATACAGATGTCCCAGGGCAAAGGAGGGTACAGTCACAGGACCTCAGACACAGGACAAGGTGCAAA
CACAGACAAGCCCATCAGGGGGCTCCCAACCCCACACACCTACGCTATGATGGAATCTCGAGTCTCGACTCCCGACTCCTCTCAGATCTA
TGCACACTTGAGGAAATCTCGGTGGGCAGCGACCTGCCAGGGTCTGTCCCTAAGGAGGTGGTCCGCTGACCTCTCAAGGGGTGGGGGTGG
GGTCAGAGCTTACAGGTTTCTGTCTTCTTGTGCTTTTAGATGCAGTTGCTCTGTCCTGACCAGGTGACCGGGCCTCAGCTGGGGGTGGAG
GGGCAATTGGAAGGCTGTTTGCCTCTGGCAAAGTCTGGGATCTGTGCTTGTGTGAGGTTAACCCACCCCCACTTCCACTCTAGGCCCCAG
GTGAGACTCCACCACCAGTCCTGCTAGTGAGGGTTCCCCGGTGAGGGTAAGGTTGGTGGGGGTGCAGCGCTTCACAATGCTAAAGCCTTA
GCCCTCCTCCAAGAGCTGAGACCTCTCAGGGCCTGAATCTTCTTTTCCACAAGATAAATGATGCAAAGGCCACACACACAGGAAAAAAAA
AAAAAGAGGCAGAACTATCTATTCTTTGCACAAAGTTTCCACTGCAAGAGGAGGAGGTGATGCAGGTGCCACCTCCACCCTGCACTTGCT
CCTCAGAACCAGGGATAAACTGCATTTGTAAAAGGCACTGTTCTTAGCAATTTCTGGACATTCAACAACGTGGGGGGCGGCCACTGGTCA
GAGGCAGGACAGCAGCCAAGATGGGGAGAGAAACGGGGAGAGAAAGAAACGATTCTAACTGACTCCTATATGCAGCCAGTTGGAATCATG
CCTAAAGCTTTGGGTCTGAAGGGGCCCCCAACACACCACCTGCCTTGGGAAACAGCGAGGATGGTGCAGAGCTTTATTGAGACTCCAGTG
GCCCATCCAGTTCATCTCCAGGCACCCCCAAAAACAGCAAATTACACAAGACCCCCCCCAAAAAAAATGAACACCATTTTCCACACATAC

>55308_55308_5_MSI2-CISD3_MSI2_chr17_55478832_ENST00000416426_CISD3_chr17_36887012_ENST00000439660_length(amino acids)=238AA_BP=127
MGRLGGRQRSARVKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFP
RRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKDLNPRRDISSWLAQWFPRTPARSVVALKTPIKVELVAGKTYRWCVCGRSKKQP

--------------------------------------------------------------
>55308_55308_6_MSI2-CISD3_MSI2_chr17_55478832_ENST00000416426_CISD3_chr17_36887013_ENST00000439660_length(transcript)=2376nt_BP=474nt
AGAGCCAGAGAGAACTTCCAGCGCAAAAGGAAAATAAAACTTGTGGCTGGTGTTTGTGCAGGAGGGTCTCCGCCATCCTGAAGCCCCCCG
ATCCTGGGGCGTCTCGGGGGCCGCCAAAGGAGCGCCAGGGTTAAAATGTTTATCGGTGGACTGAGCTGGCAGACCTCACCAGATAGCCTT
AGAGACTATTTTAGCAAATTTGGAGAAATTAGAGAATGTATGGTCATGAGAGATCCCACTACGAAACGCTCCAGAGGCTTCGGTTTCGTC
ACGTTCGCAGACCCAGCAAGTGTAGATAAAGTATTAGGTCAGCCCCACCATGAGTTAGATTCCAAGACGATTGACCCCAAAGTTGCATTT
CCTCGTCGAGCGCAACCCAAGATGGTCACAAGAACAAAGAAAATATTTGTAGGCGGGTTATCTGCGAACACAGTAGTGGAAGATGTAAAG
CAATATTTCGAGCAGTTTGGCAAGGACCTGAACCCGCGGCGGGACATCTCCTCCTGGCTGGCCCAGTGGTTCCCTAGAACCCCAGCCAGG
TCCGTGGTGGCCCTGAAGACCCCCATCAAGGTGGAGCTGGTGGCAGGGAAAACCTACAGGTGGTGTGTGTGTGGCCGCAGCAAGAAGCAG
CCCTTCTGTGACGGCTCCCACTTCTTCCAACGCACTGGCCTATCTCCACTCAAGTTCAAGGCCCAAGAGACCCGCATGGTGGCACTCTGT
ACCTGCAAGGCCACTCAGAGGCCCCCGTACTGCGATGGCACCCACAGGAGTGAGCGCGTGCAGAAGGCAGAAGTGGGCTCCCCACTCTGA
GGGGGCTGCTGCTGTCCAGCCACAGGTGGCCTTGGCTCCAGGCCTCTGACAGGCACCCCCTTCTGTGGGAAAGGAAACAGGTGCTGAGCC
CAAGAGACTCTGGTACCCACTGCTGGCTCATGAAGGAAGAATTATTCCTTATAACCTAAAAGTCTCCAGTCTGGGGCAGGCGGGAGTGGG
CCCTGGTTCAATGTTTGCTGATGGGGAAGATGGCAAAAACAAGCCTGCCCAACCAGACTGGTAGTCCTGCAGTCACTGCTATGAGGCCCA
CGTGCTGCCTCCTGCTCCAGATTTTAACCTCTCTGTGGGCTGGGGGCACCTGACCAGCCACAGGAGAGGGCAGTTCAGATTCATTCTGTA
TGGGGTCCCCAAGCCAGGCTAAACCCAGAGATGAGAGGCACCCTTCCCTTCTTCCCTCCACCCCAAAGAACTACAGGCTCCAGAAAGTAT
GCAGCATTTATTACAAAGCCAAGAGATACAGATGTCCCAGGGCAAAGGAGGGTACAGTCACAGGACCTCAGACACAGGACAAGGTGCAAA
CACAGACAAGCCCATCAGGGGGCTCCCAACCCCACACACCTACGCTATGATGGAATCTCGAGTCTCGACTCCCGACTCCTCTCAGATCTA
TGCACACTTGAGGAAATCTCGGTGGGCAGCGACCTGCCAGGGTCTGTCCCTAAGGAGGTGGTCCGCTGACCTCTCAAGGGGTGGGGGTGG
GGTCAGAGCTTACAGGTTTCTGTCTTCTTGTGCTTTTAGATGCAGTTGCTCTGTCCTGACCAGGTGACCGGGCCTCAGCTGGGGGTGGAG
GGGCAATTGGAAGGCTGTTTGCCTCTGGCAAAGTCTGGGATCTGTGCTTGTGTGAGGTTAACCCACCCCCACTTCCACTCTAGGCCCCAG
GTGAGACTCCACCACCAGTCCTGCTAGTGAGGGTTCCCCGGTGAGGGTAAGGTTGGTGGGGGTGCAGCGCTTCACAATGCTAAAGCCTTA
GCCCTCCTCCAAGAGCTGAGACCTCTCAGGGCCTGAATCTTCTTTTCCACAAGATAAATGATGCAAAGGCCACACACACAGGAAAAAAAA
AAAAAGAGGCAGAACTATCTATTCTTTGCACAAAGTTTCCACTGCAAGAGGAGGAGGTGATGCAGGTGCCACCTCCACCCTGCACTTGCT
CCTCAGAACCAGGGATAAACTGCATTTGTAAAAGGCACTGTTCTTAGCAATTTCTGGACATTCAACAACGTGGGGGGCGGCCACTGGTCA
GAGGCAGGACAGCAGCCAAGATGGGGAGAGAAACGGGGAGAGAAAGAAACGATTCTAACTGACTCCTATATGCAGCCAGTTGGAATCATG
CCTAAAGCTTTGGGTCTGAAGGGGCCCCCAACACACCACCTGCCTTGGGAAACAGCGAGGATGGTGCAGAGCTTTATTGAGACTCCAGTG
GCCCATCCAGTTCATCTCCAGGCACCCCCAAAAACAGCAAATTACACAAGACCCCCCCCAAAAAAAATGAACACCATTTTCCACACATAC

>55308_55308_6_MSI2-CISD3_MSI2_chr17_55478832_ENST00000416426_CISD3_chr17_36887013_ENST00000439660_length(amino acids)=238AA_BP=127
MGRLGGRQRSARVKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFP
RRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKDLNPRRDISSWLAQWFPRTPARSVVALKTPIKVELVAGKTYRWCVCGRSKKQP

--------------------------------------------------------------
>55308_55308_7_MSI2-CISD3_MSI2_chr17_55478832_ENST00000442934_CISD3_chr17_36887012_ENST00000439660_length(transcript)=2164nt_BP=262nt
TTTCTGTTGTGTAGTTCTGATTTTCCGAACAGGTGTTTAGATGATGAGGGGTTATATTAAGAAAGTACTAAAGAATACGTCTTATCACGT
GAATCAGTATCTTTTTATTCAACATGGATGGAGTGGGAGTGGAGACCAATCTGTTTTATATTCCTGCAATCTGATGAGGATGGTCACAAG
AACAAAGAAAATATTTGTAGGCGGGTTATCTGCGAACACAGTAGTGGAAGATGTAAAGCAATATTTCGAGCAGTTTGGCAAGGACCTGAA
CCCGCGGCGGGACATCTCCTCCTGGCTGGCCCAGTGGTTCCCTAGAACCCCAGCCAGGTCCGTGGTGGCCCTGAAGACCCCCATCAAGGT
GGAGCTGGTGGCAGGGAAAACCTACAGGTGGTGTGTGTGTGGCCGCAGCAAGAAGCAGCCCTTCTGTGACGGCTCCCACTTCTTCCAACG
CACTGGCCTATCTCCACTCAAGTTCAAGGCCCAAGAGACCCGCATGGTGGCACTCTGTACCTGCAAGGCCACTCAGAGGCCCCCGTACTG
CGATGGCACCCACAGGAGTGAGCGCGTGCAGAAGGCAGAAGTGGGCTCCCCACTCTGAGGGGGCTGCTGCTGTCCAGCCACAGGTGGCCT
TGGCTCCAGGCCTCTGACAGGCACCCCCTTCTGTGGGAAAGGAAACAGGTGCTGAGCCCAAGAGACTCTGGTACCCACTGCTGGCTCATG
AAGGAAGAATTATTCCTTATAACCTAAAAGTCTCCAGTCTGGGGCAGGCGGGAGTGGGCCCTGGTTCAATGTTTGCTGATGGGGAAGATG
GCAAAAACAAGCCTGCCCAACCAGACTGGTAGTCCTGCAGTCACTGCTATGAGGCCCACGTGCTGCCTCCTGCTCCAGATTTTAACCTCT
CTGTGGGCTGGGGGCACCTGACCAGCCACAGGAGAGGGCAGTTCAGATTCATTCTGTATGGGGTCCCCAAGCCAGGCTAAACCCAGAGAT
GAGAGGCACCCTTCCCTTCTTCCCTCCACCCCAAAGAACTACAGGCTCCAGAAAGTATGCAGCATTTATTACAAAGCCAAGAGATACAGA
TGTCCCAGGGCAAAGGAGGGTACAGTCACAGGACCTCAGACACAGGACAAGGTGCAAACACAGACAAGCCCATCAGGGGGCTCCCAACCC
CACACACCTACGCTATGATGGAATCTCGAGTCTCGACTCCCGACTCCTCTCAGATCTATGCACACTTGAGGAAATCTCGGTGGGCAGCGA
CCTGCCAGGGTCTGTCCCTAAGGAGGTGGTCCGCTGACCTCTCAAGGGGTGGGGGTGGGGTCAGAGCTTACAGGTTTCTGTCTTCTTGTG
CTTTTAGATGCAGTTGCTCTGTCCTGACCAGGTGACCGGGCCTCAGCTGGGGGTGGAGGGGCAATTGGAAGGCTGTTTGCCTCTGGCAAA
GTCTGGGATCTGTGCTTGTGTGAGGTTAACCCACCCCCACTTCCACTCTAGGCCCCAGGTGAGACTCCACCACCAGTCCTGCTAGTGAGG
GTTCCCCGGTGAGGGTAAGGTTGGTGGGGGTGCAGCGCTTCACAATGCTAAAGCCTTAGCCCTCCTCCAAGAGCTGAGACCTCTCAGGGC
CTGAATCTTCTTTTCCACAAGATAAATGATGCAAAGGCCACACACACAGGAAAAAAAAAAAAAGAGGCAGAACTATCTATTCTTTGCACA
AAGTTTCCACTGCAAGAGGAGGAGGTGATGCAGGTGCCACCTCCACCCTGCACTTGCTCCTCAGAACCAGGGATAAACTGCATTTGTAAA
AGGCACTGTTCTTAGCAATTTCTGGACATTCAACAACGTGGGGGGCGGCCACTGGTCAGAGGCAGGACAGCAGCCAAGATGGGGAGAGAA
ACGGGGAGAGAAAGAAACGATTCTAACTGACTCCTATATGCAGCCAGTTGGAATCATGCCTAAAGCTTTGGGTCTGAAGGGGCCCCCAAC
ACACCACCTGCCTTGGGAAACAGCGAGGATGGTGCAGAGCTTTATTGAGACTCCAGTGGCCCATCCAGTTCATCTCCAGGCACCCCCAAA
AACAGCAAATTACACAAGACCCCCCCCAAAAAAAATGAACACCATTTTCCACACATACACACACACATAAAGTTTGTTTCCTGTGGCATT

>55308_55308_7_MSI2-CISD3_MSI2_chr17_55478832_ENST00000442934_CISD3_chr17_36887012_ENST00000439660_length(amino acids)=185AA_BP=74
MMRGYIKKVLKNTSYHVNQYLFIQHGWSGSGDQSVLYSCNLMRMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKDLNPRRDISSWLAQWF
PRTPARSVVALKTPIKVELVAGKTYRWCVCGRSKKQPFCDGSHFFQRTGLSPLKFKAQETRMVALCTCKATQRPPYCDGTHRSERVQKAE

--------------------------------------------------------------
>55308_55308_8_MSI2-CISD3_MSI2_chr17_55478832_ENST00000442934_CISD3_chr17_36887013_ENST00000439660_length(transcript)=2164nt_BP=262nt
TTTCTGTTGTGTAGTTCTGATTTTCCGAACAGGTGTTTAGATGATGAGGGGTTATATTAAGAAAGTACTAAAGAATACGTCTTATCACGT
GAATCAGTATCTTTTTATTCAACATGGATGGAGTGGGAGTGGAGACCAATCTGTTTTATATTCCTGCAATCTGATGAGGATGGTCACAAG
AACAAAGAAAATATTTGTAGGCGGGTTATCTGCGAACACAGTAGTGGAAGATGTAAAGCAATATTTCGAGCAGTTTGGCAAGGACCTGAA
CCCGCGGCGGGACATCTCCTCCTGGCTGGCCCAGTGGTTCCCTAGAACCCCAGCCAGGTCCGTGGTGGCCCTGAAGACCCCCATCAAGGT
GGAGCTGGTGGCAGGGAAAACCTACAGGTGGTGTGTGTGTGGCCGCAGCAAGAAGCAGCCCTTCTGTGACGGCTCCCACTTCTTCCAACG
CACTGGCCTATCTCCACTCAAGTTCAAGGCCCAAGAGACCCGCATGGTGGCACTCTGTACCTGCAAGGCCACTCAGAGGCCCCCGTACTG
CGATGGCACCCACAGGAGTGAGCGCGTGCAGAAGGCAGAAGTGGGCTCCCCACTCTGAGGGGGCTGCTGCTGTCCAGCCACAGGTGGCCT
TGGCTCCAGGCCTCTGACAGGCACCCCCTTCTGTGGGAAAGGAAACAGGTGCTGAGCCCAAGAGACTCTGGTACCCACTGCTGGCTCATG
AAGGAAGAATTATTCCTTATAACCTAAAAGTCTCCAGTCTGGGGCAGGCGGGAGTGGGCCCTGGTTCAATGTTTGCTGATGGGGAAGATG
GCAAAAACAAGCCTGCCCAACCAGACTGGTAGTCCTGCAGTCACTGCTATGAGGCCCACGTGCTGCCTCCTGCTCCAGATTTTAACCTCT
CTGTGGGCTGGGGGCACCTGACCAGCCACAGGAGAGGGCAGTTCAGATTCATTCTGTATGGGGTCCCCAAGCCAGGCTAAACCCAGAGAT
GAGAGGCACCCTTCCCTTCTTCCCTCCACCCCAAAGAACTACAGGCTCCAGAAAGTATGCAGCATTTATTACAAAGCCAAGAGATACAGA
TGTCCCAGGGCAAAGGAGGGTACAGTCACAGGACCTCAGACACAGGACAAGGTGCAAACACAGACAAGCCCATCAGGGGGCTCCCAACCC
CACACACCTACGCTATGATGGAATCTCGAGTCTCGACTCCCGACTCCTCTCAGATCTATGCACACTTGAGGAAATCTCGGTGGGCAGCGA
CCTGCCAGGGTCTGTCCCTAAGGAGGTGGTCCGCTGACCTCTCAAGGGGTGGGGGTGGGGTCAGAGCTTACAGGTTTCTGTCTTCTTGTG
CTTTTAGATGCAGTTGCTCTGTCCTGACCAGGTGACCGGGCCTCAGCTGGGGGTGGAGGGGCAATTGGAAGGCTGTTTGCCTCTGGCAAA
GTCTGGGATCTGTGCTTGTGTGAGGTTAACCCACCCCCACTTCCACTCTAGGCCCCAGGTGAGACTCCACCACCAGTCCTGCTAGTGAGG
GTTCCCCGGTGAGGGTAAGGTTGGTGGGGGTGCAGCGCTTCACAATGCTAAAGCCTTAGCCCTCCTCCAAGAGCTGAGACCTCTCAGGGC
CTGAATCTTCTTTTCCACAAGATAAATGATGCAAAGGCCACACACACAGGAAAAAAAAAAAAAGAGGCAGAACTATCTATTCTTTGCACA
AAGTTTCCACTGCAAGAGGAGGAGGTGATGCAGGTGCCACCTCCACCCTGCACTTGCTCCTCAGAACCAGGGATAAACTGCATTTGTAAA
AGGCACTGTTCTTAGCAATTTCTGGACATTCAACAACGTGGGGGGCGGCCACTGGTCAGAGGCAGGACAGCAGCCAAGATGGGGAGAGAA
ACGGGGAGAGAAAGAAACGATTCTAACTGACTCCTATATGCAGCCAGTTGGAATCATGCCTAAAGCTTTGGGTCTGAAGGGGCCCCCAAC
ACACCACCTGCCTTGGGAAACAGCGAGGATGGTGCAGAGCTTTATTGAGACTCCAGTGGCCCATCCAGTTCATCTCCAGGCACCCCCAAA
AACAGCAAATTACACAAGACCCCCCCCAAAAAAAATGAACACCATTTTCCACACATACACACACACATAAAGTTTGTTTCCTGTGGCATT

>55308_55308_8_MSI2-CISD3_MSI2_chr17_55478832_ENST00000442934_CISD3_chr17_36887013_ENST00000439660_length(amino acids)=185AA_BP=74
MMRGYIKKVLKNTSYHVNQYLFIQHGWSGSGDQSVLYSCNLMRMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKDLNPRRDISSWLAQWF
PRTPARSVVALKTPIKVELVAGKTYRWCVCGRSKKQPFCDGSHFFQRTGLSPLKFKAQETRMVALCTCKATQRPPYCDGTHRSERVQKAE

--------------------------------------------------------------
>55308_55308_9_MSI2-CISD3_MSI2_chr17_55478832_ENST00000579180_CISD3_chr17_36887012_ENST00000439660_length(transcript)=2100nt_BP=198nt
CAAGTCAGTCGATCCTGTGTTTGTGCTCCCGAAGGACTTGGCGACTTGGCTAACAAGGAGACATTTGTTATTTCATTTCCTCATCCATTA
TTCATGCAGTGAGAGATGGTCACAAGAACAAAGAAAATATTTGTAGGCGGGTTATCTGCGAACACAGTAGTGGAAGATGTAAAGCAATAT
TTCGAGCAGTTTGGCAAGGACCTGAACCCGCGGCGGGACATCTCCTCCTGGCTGGCCCAGTGGTTCCCTAGAACCCCAGCCAGGTCCGTG
GTGGCCCTGAAGACCCCCATCAAGGTGGAGCTGGTGGCAGGGAAAACCTACAGGTGGTGTGTGTGTGGCCGCAGCAAGAAGCAGCCCTTC
TGTGACGGCTCCCACTTCTTCCAACGCACTGGCCTATCTCCACTCAAGTTCAAGGCCCAAGAGACCCGCATGGTGGCACTCTGTACCTGC
AAGGCCACTCAGAGGCCCCCGTACTGCGATGGCACCCACAGGAGTGAGCGCGTGCAGAAGGCAGAAGTGGGCTCCCCACTCTGAGGGGGC
TGCTGCTGTCCAGCCACAGGTGGCCTTGGCTCCAGGCCTCTGACAGGCACCCCCTTCTGTGGGAAAGGAAACAGGTGCTGAGCCCAAGAG
ACTCTGGTACCCACTGCTGGCTCATGAAGGAAGAATTATTCCTTATAACCTAAAAGTCTCCAGTCTGGGGCAGGCGGGAGTGGGCCCTGG
TTCAATGTTTGCTGATGGGGAAGATGGCAAAAACAAGCCTGCCCAACCAGACTGGTAGTCCTGCAGTCACTGCTATGAGGCCCACGTGCT
GCCTCCTGCTCCAGATTTTAACCTCTCTGTGGGCTGGGGGCACCTGACCAGCCACAGGAGAGGGCAGTTCAGATTCATTCTGTATGGGGT
CCCCAAGCCAGGCTAAACCCAGAGATGAGAGGCACCCTTCCCTTCTTCCCTCCACCCCAAAGAACTACAGGCTCCAGAAAGTATGCAGCA
TTTATTACAAAGCCAAGAGATACAGATGTCCCAGGGCAAAGGAGGGTACAGTCACAGGACCTCAGACACAGGACAAGGTGCAAACACAGA
CAAGCCCATCAGGGGGCTCCCAACCCCACACACCTACGCTATGATGGAATCTCGAGTCTCGACTCCCGACTCCTCTCAGATCTATGCACA
CTTGAGGAAATCTCGGTGGGCAGCGACCTGCCAGGGTCTGTCCCTAAGGAGGTGGTCCGCTGACCTCTCAAGGGGTGGGGGTGGGGTCAG
AGCTTACAGGTTTCTGTCTTCTTGTGCTTTTAGATGCAGTTGCTCTGTCCTGACCAGGTGACCGGGCCTCAGCTGGGGGTGGAGGGGCAA
TTGGAAGGCTGTTTGCCTCTGGCAAAGTCTGGGATCTGTGCTTGTGTGAGGTTAACCCACCCCCACTTCCACTCTAGGCCCCAGGTGAGA
CTCCACCACCAGTCCTGCTAGTGAGGGTTCCCCGGTGAGGGTAAGGTTGGTGGGGGTGCAGCGCTTCACAATGCTAAAGCCTTAGCCCTC
CTCCAAGAGCTGAGACCTCTCAGGGCCTGAATCTTCTTTTCCACAAGATAAATGATGCAAAGGCCACACACACAGGAAAAAAAAAAAAAG
AGGCAGAACTATCTATTCTTTGCACAAAGTTTCCACTGCAAGAGGAGGAGGTGATGCAGGTGCCACCTCCACCCTGCACTTGCTCCTCAG
AACCAGGGATAAACTGCATTTGTAAAAGGCACTGTTCTTAGCAATTTCTGGACATTCAACAACGTGGGGGGCGGCCACTGGTCAGAGGCA
GGACAGCAGCCAAGATGGGGAGAGAAACGGGGAGAGAAAGAAACGATTCTAACTGACTCCTATATGCAGCCAGTTGGAATCATGCCTAAA
GCTTTGGGTCTGAAGGGGCCCCCAACACACCACCTGCCTTGGGAAACAGCGAGGATGGTGCAGAGCTTTATTGAGACTCCAGTGGCCCAT
CCAGTTCATCTCCAGGCACCCCCAAAAACAGCAAATTACACAAGACCCCCCCCAAAAAAAATGAACACCATTTTCCACACATACACACAC

>55308_55308_9_MSI2-CISD3_MSI2_chr17_55478832_ENST00000579180_CISD3_chr17_36887012_ENST00000439660_length(amino acids)=142AA_BP=31
MVTRTKKIFVGGLSANTVVEDVKQYFEQFGKDLNPRRDISSWLAQWFPRTPARSVVALKTPIKVELVAGKTYRWCVCGRSKKQPFCDGSH

--------------------------------------------------------------
>55308_55308_10_MSI2-CISD3_MSI2_chr17_55478832_ENST00000579180_CISD3_chr17_36887013_ENST00000439660_length(transcript)=2100nt_BP=198nt
CAAGTCAGTCGATCCTGTGTTTGTGCTCCCGAAGGACTTGGCGACTTGGCTAACAAGGAGACATTTGTTATTTCATTTCCTCATCCATTA
TTCATGCAGTGAGAGATGGTCACAAGAACAAAGAAAATATTTGTAGGCGGGTTATCTGCGAACACAGTAGTGGAAGATGTAAAGCAATAT
TTCGAGCAGTTTGGCAAGGACCTGAACCCGCGGCGGGACATCTCCTCCTGGCTGGCCCAGTGGTTCCCTAGAACCCCAGCCAGGTCCGTG
GTGGCCCTGAAGACCCCCATCAAGGTGGAGCTGGTGGCAGGGAAAACCTACAGGTGGTGTGTGTGTGGCCGCAGCAAGAAGCAGCCCTTC
TGTGACGGCTCCCACTTCTTCCAACGCACTGGCCTATCTCCACTCAAGTTCAAGGCCCAAGAGACCCGCATGGTGGCACTCTGTACCTGC
AAGGCCACTCAGAGGCCCCCGTACTGCGATGGCACCCACAGGAGTGAGCGCGTGCAGAAGGCAGAAGTGGGCTCCCCACTCTGAGGGGGC
TGCTGCTGTCCAGCCACAGGTGGCCTTGGCTCCAGGCCTCTGACAGGCACCCCCTTCTGTGGGAAAGGAAACAGGTGCTGAGCCCAAGAG
ACTCTGGTACCCACTGCTGGCTCATGAAGGAAGAATTATTCCTTATAACCTAAAAGTCTCCAGTCTGGGGCAGGCGGGAGTGGGCCCTGG
TTCAATGTTTGCTGATGGGGAAGATGGCAAAAACAAGCCTGCCCAACCAGACTGGTAGTCCTGCAGTCACTGCTATGAGGCCCACGTGCT
GCCTCCTGCTCCAGATTTTAACCTCTCTGTGGGCTGGGGGCACCTGACCAGCCACAGGAGAGGGCAGTTCAGATTCATTCTGTATGGGGT
CCCCAAGCCAGGCTAAACCCAGAGATGAGAGGCACCCTTCCCTTCTTCCCTCCACCCCAAAGAACTACAGGCTCCAGAAAGTATGCAGCA
TTTATTACAAAGCCAAGAGATACAGATGTCCCAGGGCAAAGGAGGGTACAGTCACAGGACCTCAGACACAGGACAAGGTGCAAACACAGA
CAAGCCCATCAGGGGGCTCCCAACCCCACACACCTACGCTATGATGGAATCTCGAGTCTCGACTCCCGACTCCTCTCAGATCTATGCACA
CTTGAGGAAATCTCGGTGGGCAGCGACCTGCCAGGGTCTGTCCCTAAGGAGGTGGTCCGCTGACCTCTCAAGGGGTGGGGGTGGGGTCAG
AGCTTACAGGTTTCTGTCTTCTTGTGCTTTTAGATGCAGTTGCTCTGTCCTGACCAGGTGACCGGGCCTCAGCTGGGGGTGGAGGGGCAA
TTGGAAGGCTGTTTGCCTCTGGCAAAGTCTGGGATCTGTGCTTGTGTGAGGTTAACCCACCCCCACTTCCACTCTAGGCCCCAGGTGAGA
CTCCACCACCAGTCCTGCTAGTGAGGGTTCCCCGGTGAGGGTAAGGTTGGTGGGGGTGCAGCGCTTCACAATGCTAAAGCCTTAGCCCTC
CTCCAAGAGCTGAGACCTCTCAGGGCCTGAATCTTCTTTTCCACAAGATAAATGATGCAAAGGCCACACACACAGGAAAAAAAAAAAAAG
AGGCAGAACTATCTATTCTTTGCACAAAGTTTCCACTGCAAGAGGAGGAGGTGATGCAGGTGCCACCTCCACCCTGCACTTGCTCCTCAG
AACCAGGGATAAACTGCATTTGTAAAAGGCACTGTTCTTAGCAATTTCTGGACATTCAACAACGTGGGGGGCGGCCACTGGTCAGAGGCA
GGACAGCAGCCAAGATGGGGAGAGAAACGGGGAGAGAAAGAAACGATTCTAACTGACTCCTATATGCAGCCAGTTGGAATCATGCCTAAA
GCTTTGGGTCTGAAGGGGCCCCCAACACACCACCTGCCTTGGGAAACAGCGAGGATGGTGCAGAGCTTTATTGAGACTCCAGTGGCCCAT
CCAGTTCATCTCCAGGCACCCCCAAAAACAGCAAATTACACAAGACCCCCCCCAAAAAAAATGAACACCATTTTCCACACATACACACAC

>55308_55308_10_MSI2-CISD3_MSI2_chr17_55478832_ENST00000579180_CISD3_chr17_36887013_ENST00000439660_length(amino acids)=142AA_BP=31
MVTRTKKIFVGGLSANTVVEDVKQYFEQFGKDLNPRRDISSWLAQWFPRTPARSVVALKTPIKVELVAGKTYRWCVCGRSKKQPFCDGSH

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MSI2-CISD3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MSI2-CISD3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MSI2-CISD3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source