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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MSI2-SLC39A11 (FusionGDB2 ID:55331)

Fusion Gene Summary for MSI2-SLC39A11

Fusion gene summary

Fusion gene information	Fusion gene name: MSI2-SLC39A11
	Fusion gene ID: 55331
		Hgene	Tgene
	Gene symbol	MSI2	SLC39A11
	Gene ID	124540	201266
	Gene name	musashi RNA binding protein 2	solute carrier family 39 member 11
	Synonyms	MSI2H	C17orf26\|ZIP-11\|ZIP11
	Cytomap	17q22	17q24.3-q25.1
	Type of gene	protein-coding	protein-coding
	Description	RNA-binding protein Musashi homolog 2musashi homolog 2musashi-2	zinc transporter ZIP11Zrt- and Irt-like protein 11solute carrier family 39 (metal ion transporter), member 11
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000284073, ENST00000322684, ENST00000416426, ENST00000442934, ENST00000579180, ENST00000579505,	ENST00000579732, ENST00000579988, ENST00000255559, ENST00000542342,
Fusion gene scores	* DoF score	40 X 16 X 16=10240	24 X 14 X 9=3024
	# samples	45	29
	** MAII score	log2(45/10240*10)=-4.50814690367033 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(29/3024*10)=-3.38233333420614 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MSI2 [Title/Abstract] AND SLC39A11 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MSI2(55339553)-SLC39A11(71027853), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MSI2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SLC39A11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AN-A0FW-01A	MSI2	chr17	55339553	-	SLC39A11	chr17	71027853	-
ChimerDB4	BRCA	TCGA-AN-A0FW-01A	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-
ChimerDB4	BRCA	TCGA-AN-A0FW	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-

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Fusion Gene ORF analysis for MSI2-SLC39A11

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000284073	ENST00000579732	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-
5CDS-intron	ENST00000284073	ENST00000579988	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-
5CDS-intron	ENST00000322684	ENST00000579732	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-
5CDS-intron	ENST00000322684	ENST00000579988	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-
5CDS-intron	ENST00000416426	ENST00000579732	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-
5CDS-intron	ENST00000416426	ENST00000579988	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-
In-frame	ENST00000284073	ENST00000255559	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-
In-frame	ENST00000284073	ENST00000542342	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-
In-frame	ENST00000322684	ENST00000255559	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-
In-frame	ENST00000322684	ENST00000542342	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-
In-frame	ENST00000416426	ENST00000255559	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-
In-frame	ENST00000416426	ENST00000542342	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-
intron-3CDS	ENST00000442934	ENST00000255559	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-
intron-3CDS	ENST00000442934	ENST00000542342	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-
intron-3CDS	ENST00000579180	ENST00000255559	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-
intron-3CDS	ENST00000579180	ENST00000542342	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-
intron-3CDS	ENST00000579505	ENST00000255559	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-
intron-3CDS	ENST00000579505	ENST00000542342	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-
intron-intron	ENST00000442934	ENST00000579732	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-
intron-intron	ENST00000442934	ENST00000579988	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-
intron-intron	ENST00000579180	ENST00000579732	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-
intron-intron	ENST00000579180	ENST00000579988	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-
intron-intron	ENST00000579505	ENST00000579732	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-
intron-intron	ENST00000579505	ENST00000579988	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000416426	MSI2	chr17	55339553	+	ENST00000255559	SLC39A11	chr17	71027853	-	2877	381	93	1241	382
ENST00000416426	MSI2	chr17	55339553	+	ENST00000542342	SLC39A11	chr17	71027853	-	2897	381	93	1262	389
ENST00000284073	MSI2	chr17	55339553	+	ENST00000255559	SLC39A11	chr17	71027853	-	3017	521	179	1381	400
ENST00000284073	MSI2	chr17	55339553	+	ENST00000542342	SLC39A11	chr17	71027853	-	3037	521	179	1402	407
ENST00000322684	MSI2	chr17	55339553	+	ENST00000255559	SLC39A11	chr17	71027853	-	2831	335	35	1195	386
ENST00000322684	MSI2	chr17	55339553	+	ENST00000542342	SLC39A11	chr17	71027853	-	2851	335	35	1216	393

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000416426	ENST00000255559	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-	0.003694717	0.99630535
ENST00000416426	ENST00000542342	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-	0.005200877	0.99479914
ENST00000284073	ENST00000255559	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-	0.003417048	0.9965829
ENST00000284073	ENST00000542342	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-	0.00418955	0.9958105
ENST00000322684	ENST00000255559	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-	0.001956762	0.9980432
ENST00000322684	ENST00000542342	MSI2	chr17	55339553	+	SLC39A11	chr17	71027853	-	0.002002292	0.9979977

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Fusion Genomic Features for MSI2-SLC39A11

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MSI2-SLC39A11

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:55339553/chr17:71027853)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SLC39A11

chr17:55339553

chr17:71027853

ENST00000255559

194_214

336.0

Transmembrane

Helical

Tgene

SLC39A11

chr17:55339553

chr17:71027853

ENST00000255559

263_285

336.0

Transmembrane

Helical

Tgene

SLC39A11

chr17:55339553

chr17:71027853

ENST00000255559

290_307

336.0

Transmembrane

Helical

Tgene

SLC39A11

chr17:55339553

chr17:71027853

ENST00000255559

322_342

336.0

Transmembrane

Helical

Tgene

SLC39A11

chr17:55339553

chr17:71027853

ENST00000255559

72_92

336.0

Transmembrane

Helical

Tgene

SLC39A11

chr17:55339553

chr17:71027853

ENST00000542342

194_214

343.0

Transmembrane

Helical

Tgene

SLC39A11

chr17:55339553

chr17:71027853

ENST00000542342

263_285

343.0

Transmembrane

Helical

Tgene

SLC39A11

chr17:55339553

chr17:71027853

ENST00000542342

290_307

343.0

Transmembrane

Helical

Tgene

SLC39A11

chr17:55339553

chr17:71027853

ENST00000542342

322_342

343.0

Transmembrane

Helical

Tgene

SLC39A11

chr17:55339553

chr17:71027853

ENST00000542342

72_92

343.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MSI2

chr17:55339553

chr17:71027853

ENST00000284073

253_260

104

1951.0

Compositional bias

Note=Poly-Ala

Hgene

MSI2

chr17:55339553

chr17:71027853

ENST00000322684

253_260

100

252.0

Compositional bias

Note=Poly-Ala

Hgene

MSI2

chr17:55339553

chr17:71027853

ENST00000579180

253_260

152.0

Compositional bias

Note=Poly-Ala

Hgene

MSI2

chr17:55339553

chr17:71027853

ENST00000284073

110_187

104

1951.0

Domain

RRM 2

Hgene

MSI2

chr17:55339553

chr17:71027853

ENST00000284073

21_111

104

1951.0

Domain

RRM 1

Hgene

MSI2

chr17:55339553

chr17:71027853

ENST00000322684

110_187

100

252.0

Domain

RRM 2

Hgene

MSI2

chr17:55339553

chr17:71027853

ENST00000322684

21_111

100

252.0

Domain

RRM 1

Hgene

MSI2

chr17:55339553

chr17:71027853

ENST00000579180

110_187

152.0

Domain

RRM 2

Hgene

MSI2

chr17:55339553

chr17:71027853

ENST00000579180

21_111

152.0

Domain

RRM 1

Tgene

SLC39A11

chr17:55339553

chr17:71027853

ENST00000255559

12_32

336.0

Transmembrane

Helical

Tgene

SLC39A11

chr17:55339553

chr17:71027853

ENST00000255559

44_64

336.0

Transmembrane

Helical

Tgene

SLC39A11

chr17:55339553

chr17:71027853

ENST00000542342

12_32

343.0

Transmembrane

Helical

Tgene

SLC39A11

chr17:55339553

chr17:71027853

ENST00000542342

44_64

343.0

Transmembrane

Helical

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Fusion Gene Sequence for MSI2-SLC39A11

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>55331_55331_1_MSI2-SLC39A11_MSI2_chr17_55339553_ENST00000284073_SLC39A11_chr17_71027853_ENST00000255559_length(transcript)=3017nt_BP=521nt
CGGGGCTGAGCTAAGCCGAGCCCACGTGTGACGGCTCTCGCCGCTGCCCCGGCTCCGCCGCTCGCAGAGAGATTCGGAGGAGCCCGGGCG
GGGGGGAGGAGGAGGGGGAGGAGGGAGCGGAGATCTCGGGGCTCGGAGCCGGCCGCCGCTCCGCTCCGATCGCTGTGGGGCTTGGTTTTT
TGGGGGTGGGGGGGCGGGGGGGCTCAGATATGGAGGCAAATGGGAGCCAAGGCACCTCGGGCAGCGCCAACGACTCCCAGCACGACCCCG
GTAAAATGTTTATCGGTGGACTGAGCTGGCAGACCTCACCAGATAGCCTTAGAGACTATTTTAGCAAATTTGGAGAAATTAGAGAATGTA
TGGTCATGAGAGATCCCACTACGAAACGCTCCAGAGGCTTCGGTTTCGTCACGTTCGCAGACCCAGCAAGTGTAGATAAAGTATTAGGTC
AGCCCCACCATGAGTTAGATTCCAAGACGATTGACCCCAAAGTTGCATTTCCTCGTCGAGCGCAACCCAAGGTCATGTTGGCAGCTTCCT
ATTGGTCTCTTCTGGCCCCAGCAGTTGAGATGGCCACGTCCTCTGGGGGCTTCGGTGCCTTTGCCTTCTTCCCTGTGGCTGTTGGCTTCA
CCCTTGGAGCGGCTTTTGTCTACTTGGCTGACCTCCTGATGCCTCACTTGGGTGCAGCAGAAGACCCCCAGACGACCCTGGCACTGAACT
TCGGCTCTACGTTGATGAAGAAGAAGTCTGATCCTGAGGGTCCCGCGCTGCTCTTCCCTGAGAGTGAACTTTCCATCCGGATAGACAAGA
GTGAGAATGGTGAGGCATATCAGAGAAAGAAGGCGGCAGCCACTGGCCTTCCAGAGGGTCCTGCTGTCCCTGTGCCTTCTCGAGGGAATC
TGGCACAGCCCGGCGGCAGCAGCTGGAGGAGGATCGCACTGCTCATCTTGGCCATCACTATACACAACGTTCCAGAGGGTCTCGCTGTTG
GAGTTGGATTTGGGGCTATAGAAAAGACGGCATCTGCTACCTTTGAGAGTGCCAGGAATTTGGCCATTGGAATCGGGATCCAGAATTTCC
CCGAGGGCCTGGCTGTCAGCCTTCCCTTGCGAGGGGCAGGCTTCTCCACCTGGAGAGCTTTCTGGTATGGGCAGCTGAGCGGCATGGTGG
AGCCCCTGGCCGGGGTCTTTGGTGCCTTTGCCGTGGTGCTGGCTGAGCCCATCCTGCCCTACGCTCTGGCCTTTGCTGCCGGTGCCATGG
TCTACGTGGTCATGGACGACATCATCCCCGAAGCCCAGATCAGTGGTAATGGGAAACTGGCATCCTGGGCCTCCATCCTGGGATTTGTAG
TGATGATGTCACTGGACGTTGGCCTGGGCTAGGGCTGAGACGCTTCGGACCCCGGGAAAGGCCATACGAAGAAACAGCAGTGGTTGGCTT
CTATGGGACAACAAGCTTCTTTCTTCACATTAAAACTTTTTTCCTTCCTCTCTTCTTCATCTCATTATCCTGATTGACTCTGATTATAAT
AGAACCATTTTTACTTTGCTTTGAGGGAGATTTTTGATTTAATGGGGAATTTTAAGGTGTCATGGAAATACAGATTCTTTGTTTTGGCCA
CTGAATGGACTCTCTCTTCAGTGGGATTATCAAGGAACTTCAGATCAGGGAAATCTCCACTTCGGGACCTTCTATCTGCCTCCCAACTCC
TCAAGGTCACCTATAGAAGCGAGCTACCAAAAGACGTCTCCTAAGCATTTTGGTGGCCTAGTGACTCAGGGCAGAGTGGCCAGCACACCT
CTCATCCGCCCCTCCTGCTCCATCACTGCTGAGCCTCTCCCCATCTAGAATGTTGGAACTGGAGCATCATAAAGATAGCAAGCTACCTTC
CAAGGCCGAGCCAGCCCAGAGAGGAGCATGTCTTCCTTTACCTCCCCCTAAGGAGATACTACATGGGAGGGGGACACAGAAAAAGGGAAG
GAAATTGGCTAGTCTGGCTTTTTTTTTTTTTTTTTTTAAAGGCAAAGATTGACATTATTGAAGGAAAGGGGATGAGGACAACTGTGAACT
CACAGTGAGCCCTGTGGAAAGAAGAGACAGACAGAGTGTGGGTTTGTTCGGAGGCCTCTGCTGTCAATGGATTCCAGGAGCAAGGCCATT
TGTCGCGCTTTCCAAATTTCTTAGGCATTTATTTTGATAAGTTTATAGCCATCATGTTTCTAAGAGACTTGGAGACACCAGCAAACTGCT
AGAACTCAAACTCTTCAATTACTCAAAGAAGGAGCCATTTCAGTTAACTCAAGTGAATGAAAGAGTTTTGGAATCTGCTGTGGGTCCTTC
CCTGTTGACCATTTGGTAACTTATAATCTGACAAAAACTCTTGAGCTGCAACAGGCCTTGCCAGAGGGCTCAGGATGGGAAAGGAAGAAG
GGGATAGGAAAAGAAGAGGTAATTTTACATTTCCCCTTTAAAGTAAATTTTAGCCAACTCATCATTCTGAAATGTCCCTATAAAGAATGA
GTCGAACTAGACCAGAAGCCAGCCTACTCCTTCTTACATAGCTTCTCCAACAGGGGTAGCAATGACCTGTCCACTTCAAACACAGATAAG
GCCTGCCATCCTCATTGGTTAAAGGCACACGTGAGACTTTCAGTGGGCTCTGCTGAGAAGGAAGGCAGCCCAGGAGTCAGGTATGCAGGC
ATTGCATTGTCAGTGTCTGCTCTCAGAGTTTACACATTCAATTGCTTCCAAGGGTGAATCTCCTGCTCTGTGAATGCTATCAGACCCCAA
AGGCCAACCTTGGGCTGGGTCTATGTACGTTCTTCCGAAGCACTGATGATCAAAATTGAAGACACATTCAGAGGTTTGATTGGTTGAGAT
TAACTGGTGTGGTGGTTGGTGTATGTATGTTTTATTTTTATGTCTTTGTATGTAGTTCTACATAATGCAAATTGTGCTTTCTGATGGACA

>55331_55331_1_MSI2-SLC39A11_MSI2_chr17_55339553_ENST00000284073_SLC39A11_chr17_71027853_ENST00000255559_length(amino acids)=400AA_BP=114
MGVGGRGGSDMEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLG
QPHHELDSKTIDPKVAFPRRAQPKVMLAASYWSLLAPAVEMATSSGGFGAFAFFPVAVGFTLGAAFVYLADLLMPHLGAAEDPQTTLALN
FGSTLMKKKSDPEGPALLFPESELSIRIDKSENGEAYQRKKAAATGLPEGPAVPVPSRGNLAQPGGSSWRRIALLILAITIHNVPEGLAV
GVGFGAIEKTASATFESARNLAIGIGIQNFPEGLAVSLPLRGAGFSTWRAFWYGQLSGMVEPLAGVFGAFAVVLAEPILPYALAFAAGAM

--------------------------------------------------------------
>55331_55331_2_MSI2-SLC39A11_MSI2_chr17_55339553_ENST00000284073_SLC39A11_chr17_71027853_ENST00000542342_length(transcript)=3037nt_BP=521nt
CGGGGCTGAGCTAAGCCGAGCCCACGTGTGACGGCTCTCGCCGCTGCCCCGGCTCCGCCGCTCGCAGAGAGATTCGGAGGAGCCCGGGCG
GGGGGGAGGAGGAGGGGGAGGAGGGAGCGGAGATCTCGGGGCTCGGAGCCGGCCGCCGCTCCGCTCCGATCGCTGTGGGGCTTGGTTTTT
TGGGGGTGGGGGGGCGGGGGGGCTCAGATATGGAGGCAAATGGGAGCCAAGGCACCTCGGGCAGCGCCAACGACTCCCAGCACGACCCCG
GTAAAATGTTTATCGGTGGACTGAGCTGGCAGACCTCACCAGATAGCCTTAGAGACTATTTTAGCAAATTTGGAGAAATTAGAGAATGTA
TGGTCATGAGAGATCCCACTACGAAACGCTCCAGAGGCTTCGGTTTCGTCACGTTCGCAGACCCAGCAAGTGTAGATAAAGTATTAGGTC
AGCCCCACCATGAGTTAGATTCCAAGACGATTGACCCCAAAGTTGCATTTCCTCGTCGAGCGCAACCCAAGGTCATGTTGGCAGCTTCCT
ATTGGTCTCTTCTGGCCCCAGCAGTTGAGATGGCCACGTCCTCTGGGGGCTTCGGTGCCTTTGCCTTCTTCCCTGTGGCTGTTGGCTTCA
CCCTTGGAGCGGCTTTTGTCTACTTGGCTGACCTCCTGATGCCTCACTTGGGTGCAGCAGAAGACCCCCAGACGACCCTGGCACTGAACT
TCGGCTCTACGTTGATGAAGAAGAAGTCTGATCCTGAGGGTCCCGCGCTGCTCTTCCCTGAGAGTGAACTTTCCATCCGGATAGGTAGAG
CTGGGCTTCTTTCAGACAAGAGTGAGAATGGTGAGGCATATCAGAGAAAGAAGGCGGCAGCCACTGGCCTTCCAGAGGGTCCTGCTGTCC
CTGTGCCTTCTCGAGGGAATCTGGCACAGCCCGGCGGCAGCAGCTGGAGGAGGATCGCACTGCTCATCTTGGCCATCACTATACACAACG
TTCCAGAGGGTCTCGCTGTTGGAGTTGGATTTGGGGCTATAGAAAAGACGGCATCTGCTACCTTTGAGAGTGCCAGGAATTTGGCCATTG
GAATCGGGATCCAGAATTTCCCCGAGGGCCTGGCTGTCAGCCTTCCCTTGCGAGGGGCAGGCTTCTCCACCTGGAGAGCTTTCTGGTATG
GGCAGCTGAGCGGCATGGTGGAGCCCCTGGCCGGGGTCTTTGGTGCCTTTGCCGTGGTGCTGGCTGAGCCCATCCTGCCCTACGCTCTGG
CCTTTGCTGCCGGTGCCATGGTCTACGTGGTCATGGACGACATCATCCCCGAAGCCCAGATCAGTGGTAATGGGAAACTGGCATCCTGGG
CCTCCATCCTGGGATTTGTAGTGATGATGTCACTGGACGTTGGCCTGGGCTAGGGCTGAGACGCTTCGGACCCCGGGAAAGGCCATACGA
AGAAACAGCAGTGGTTGGCTTCTATGGGACAACAAGCTTCTTTCTTCACATTAAAACTTTTTTCCTTCCTCTCTTCTTCATCTCATTATC
CTGATTGACTCTGATTATAATAGAACCATTTTTACTTTGCTTTGAGGGAGATTTTTGATTTAATGGGGAATTTTAAGGTGTCATGGAAAT
ACAGATTCTTTGTTTTGGCCACTGAATGGACTCTCTCTTCAGTGGGATTATCAAGGAACTTCAGATCAGGGAAATCTCCACTTCGGGACC
TTCTATCTGCCTCCCAACTCCTCAAGGTCACCTATAGAAGCGAGCTACCAAAAGACGTCTCCTAAGCATTTTGGTGGCCTAGTGACTCAG
GGCAGAGTGGCCAGCACACCTCTCATCCGCCCCTCCTGCTCCATCACTGCTGAGCCTCTCCCCATCTAGAATGTTGGAACTGGAGCATCA
TAAAGATAGCAAGCTACCTTCCAAGGCCGAGCCAGCCCAGAGAGGAGCATGTCTTCCTTTACCTCCCCCTAAGGAGATACTACATGGGAG
GGGGACACAGAAAAAGGGAAGGAAATTGGCTAGTCTGGCTTTTTTTTTTTTTTTTTTTAAAGGCAAAGATTGACATTATTGAAGGAAAGG
GGATGAGGACAACTGTGAACTCACAGTGAGCCCTGTGGAAAGAAGAGACAGACAGAGTGTGGGTTTGTTCGGAGGCCTCTGCTGTCAATG
GATTCCAGGAGCAAGGCCATTTGTCGCGCTTTCCAAATTTCTTAGGCATTTATTTTGATAAGTTTATAGCCATCATGTTTCTAAGAGACT
TGGAGACACCAGCAAACTGCTAGAACTCAAACTCTTCAATTACTCAAAGAAGGAGCCATTTCAGTTAACTCAAGTGAATGAAAGAGTTTT
GGAATCTGCTGTGGGTCCTTCCCTGTTGACCATTTGGTAACTTATAATCTGACAAAAACTCTTGAGCTGCAACAGGCCTTGCCAGAGGGC
TCAGGATGGGAAAGGAAGAAGGGGATAGGAAAAGAAGAGGTAATTTTACATTTCCCCTTTAAAGTAAATTTTAGCCAACTCATCATTCTG
AAATGTCCCTATAAAGAATGAGTCGAACTAGACCAGAAGCCAGCCTACTCCTTCTTACATAGCTTCTCCAACAGGGGTAGCAATGACCTG
TCCACTTCAAACACAGATAAGGCCTGCCATCCTCATTGGTTAAAGGCACACGTGAGACTTTCAGTGGGCTCTGCTGAGAAGGAAGGCAGC
CCAGGAGTCAGGTATGCAGGCATTGCATTGTCAGTGTCTGCTCTCAGAGTTTACACATTCAATTGCTTCCAAGGGTGAATCTCCTGCTCT
GTGAATGCTATCAGACCCCAAAGGCCAACCTTGGGCTGGGTCTATGTACGTTCTTCCGAAGCACTGATGATCAAAATTGAAGACACATTC
AGAGGTTTGATTGGTTGAGATTAACTGGTGTGGTGGTTGGTGTATGTATGTTTTATTTTTATGTCTTTGTATGTAGTTCTACATAATGCA

>55331_55331_2_MSI2-SLC39A11_MSI2_chr17_55339553_ENST00000284073_SLC39A11_chr17_71027853_ENST00000542342_length(amino acids)=407AA_BP=114
MGVGGRGGSDMEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLG
QPHHELDSKTIDPKVAFPRRAQPKVMLAASYWSLLAPAVEMATSSGGFGAFAFFPVAVGFTLGAAFVYLADLLMPHLGAAEDPQTTLALN
FGSTLMKKKSDPEGPALLFPESELSIRIGRAGLLSDKSENGEAYQRKKAAATGLPEGPAVPVPSRGNLAQPGGSSWRRIALLILAITIHN
VPEGLAVGVGFGAIEKTASATFESARNLAIGIGIQNFPEGLAVSLPLRGAGFSTWRAFWYGQLSGMVEPLAGVFGAFAVVLAEPILPYAL

--------------------------------------------------------------
>55331_55331_3_MSI2-SLC39A11_MSI2_chr17_55339553_ENST00000322684_SLC39A11_chr17_71027853_ENST00000255559_length(transcript)=2831nt_BP=335nt
GCTTTCCTTTTAGCTTTTGTAAGTTACACGTCAAAATGGCCGATCTGACATCGGTGCTCACTTCTGTTATGTTTTCTCCCTCTAGTAAAA
TGTTTATCGGTGGACTGAGCTGGCAGACCTCACCAGATAGCCTTAGAGACTATTTTAGCAAATTTGGAGAAATTAGAGAATGTATGGTCA
TGAGAGATCCCACTACGAAACGCTCCAGAGGCTTCGGTTTCGTCACGTTCGCAGACCCAGCAAGTGTAGATAAAGTATTAGGTCAGCCCC
ACCATGAGTTAGATTCCAAGACGATTGACCCCAAAGTTGCATTTCCTCGTCGAGCGCAACCCAAGGTCATGTTGGCAGCTTCCTATTGGT
CTCTTCTGGCCCCAGCAGTTGAGATGGCCACGTCCTCTGGGGGCTTCGGTGCCTTTGCCTTCTTCCCTGTGGCTGTTGGCTTCACCCTTG
GAGCGGCTTTTGTCTACTTGGCTGACCTCCTGATGCCTCACTTGGGTGCAGCAGAAGACCCCCAGACGACCCTGGCACTGAACTTCGGCT
CTACGTTGATGAAGAAGAAGTCTGATCCTGAGGGTCCCGCGCTGCTCTTCCCTGAGAGTGAACTTTCCATCCGGATAGACAAGAGTGAGA
ATGGTGAGGCATATCAGAGAAAGAAGGCGGCAGCCACTGGCCTTCCAGAGGGTCCTGCTGTCCCTGTGCCTTCTCGAGGGAATCTGGCAC
AGCCCGGCGGCAGCAGCTGGAGGAGGATCGCACTGCTCATCTTGGCCATCACTATACACAACGTTCCAGAGGGTCTCGCTGTTGGAGTTG
GATTTGGGGCTATAGAAAAGACGGCATCTGCTACCTTTGAGAGTGCCAGGAATTTGGCCATTGGAATCGGGATCCAGAATTTCCCCGAGG
GCCTGGCTGTCAGCCTTCCCTTGCGAGGGGCAGGCTTCTCCACCTGGAGAGCTTTCTGGTATGGGCAGCTGAGCGGCATGGTGGAGCCCC
TGGCCGGGGTCTTTGGTGCCTTTGCCGTGGTGCTGGCTGAGCCCATCCTGCCCTACGCTCTGGCCTTTGCTGCCGGTGCCATGGTCTACG
TGGTCATGGACGACATCATCCCCGAAGCCCAGATCAGTGGTAATGGGAAACTGGCATCCTGGGCCTCCATCCTGGGATTTGTAGTGATGA
TGTCACTGGACGTTGGCCTGGGCTAGGGCTGAGACGCTTCGGACCCCGGGAAAGGCCATACGAAGAAACAGCAGTGGTTGGCTTCTATGG
GACAACAAGCTTCTTTCTTCACATTAAAACTTTTTTCCTTCCTCTCTTCTTCATCTCATTATCCTGATTGACTCTGATTATAATAGAACC
ATTTTTACTTTGCTTTGAGGGAGATTTTTGATTTAATGGGGAATTTTAAGGTGTCATGGAAATACAGATTCTTTGTTTTGGCCACTGAAT
GGACTCTCTCTTCAGTGGGATTATCAAGGAACTTCAGATCAGGGAAATCTCCACTTCGGGACCTTCTATCTGCCTCCCAACTCCTCAAGG
TCACCTATAGAAGCGAGCTACCAAAAGACGTCTCCTAAGCATTTTGGTGGCCTAGTGACTCAGGGCAGAGTGGCCAGCACACCTCTCATC
CGCCCCTCCTGCTCCATCACTGCTGAGCCTCTCCCCATCTAGAATGTTGGAACTGGAGCATCATAAAGATAGCAAGCTACCTTCCAAGGC
CGAGCCAGCCCAGAGAGGAGCATGTCTTCCTTTACCTCCCCCTAAGGAGATACTACATGGGAGGGGGACACAGAAAAAGGGAAGGAAATT
GGCTAGTCTGGCTTTTTTTTTTTTTTTTTTTAAAGGCAAAGATTGACATTATTGAAGGAAAGGGGATGAGGACAACTGTGAACTCACAGT
GAGCCCTGTGGAAAGAAGAGACAGACAGAGTGTGGGTTTGTTCGGAGGCCTCTGCTGTCAATGGATTCCAGGAGCAAGGCCATTTGTCGC
GCTTTCCAAATTTCTTAGGCATTTATTTTGATAAGTTTATAGCCATCATGTTTCTAAGAGACTTGGAGACACCAGCAAACTGCTAGAACT
CAAACTCTTCAATTACTCAAAGAAGGAGCCATTTCAGTTAACTCAAGTGAATGAAAGAGTTTTGGAATCTGCTGTGGGTCCTTCCCTGTT
GACCATTTGGTAACTTATAATCTGACAAAAACTCTTGAGCTGCAACAGGCCTTGCCAGAGGGCTCAGGATGGGAAAGGAAGAAGGGGATA
GGAAAAGAAGAGGTAATTTTACATTTCCCCTTTAAAGTAAATTTTAGCCAACTCATCATTCTGAAATGTCCCTATAAAGAATGAGTCGAA
CTAGACCAGAAGCCAGCCTACTCCTTCTTACATAGCTTCTCCAACAGGGGTAGCAATGACCTGTCCACTTCAAACACAGATAAGGCCTGC
CATCCTCATTGGTTAAAGGCACACGTGAGACTTTCAGTGGGCTCTGCTGAGAAGGAAGGCAGCCCAGGAGTCAGGTATGCAGGCATTGCA
TTGTCAGTGTCTGCTCTCAGAGTTTACACATTCAATTGCTTCCAAGGGTGAATCTCCTGCTCTGTGAATGCTATCAGACCCCAAAGGCCA
ACCTTGGGCTGGGTCTATGTACGTTCTTCCGAAGCACTGATGATCAAAATTGAAGACACATTCAGAGGTTTGATTGGTTGAGATTAACTG
GTGTGGTGGTTGGTGTATGTATGTTTTATTTTTATGTCTTTGTATGTAGTTCTACATAATGCAAATTGTGCTTTCTGATGGACAAGACCT

>55331_55331_3_MSI2-SLC39A11_MSI2_chr17_55339553_ENST00000322684_SLC39A11_chr17_71027853_ENST00000255559_length(amino acids)=386AA_BP=100
MADLTSVLTSVMFSPSSKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPK
VAFPRRAQPKVMLAASYWSLLAPAVEMATSSGGFGAFAFFPVAVGFTLGAAFVYLADLLMPHLGAAEDPQTTLALNFGSTLMKKKSDPEG
PALLFPESELSIRIDKSENGEAYQRKKAAATGLPEGPAVPVPSRGNLAQPGGSSWRRIALLILAITIHNVPEGLAVGVGFGAIEKTASAT
FESARNLAIGIGIQNFPEGLAVSLPLRGAGFSTWRAFWYGQLSGMVEPLAGVFGAFAVVLAEPILPYALAFAAGAMVYVVMDDIIPEAQI

--------------------------------------------------------------
>55331_55331_4_MSI2-SLC39A11_MSI2_chr17_55339553_ENST00000322684_SLC39A11_chr17_71027853_ENST00000542342_length(transcript)=2851nt_BP=335nt
GCTTTCCTTTTAGCTTTTGTAAGTTACACGTCAAAATGGCCGATCTGACATCGGTGCTCACTTCTGTTATGTTTTCTCCCTCTAGTAAAA
TGTTTATCGGTGGACTGAGCTGGCAGACCTCACCAGATAGCCTTAGAGACTATTTTAGCAAATTTGGAGAAATTAGAGAATGTATGGTCA
TGAGAGATCCCACTACGAAACGCTCCAGAGGCTTCGGTTTCGTCACGTTCGCAGACCCAGCAAGTGTAGATAAAGTATTAGGTCAGCCCC
ACCATGAGTTAGATTCCAAGACGATTGACCCCAAAGTTGCATTTCCTCGTCGAGCGCAACCCAAGGTCATGTTGGCAGCTTCCTATTGGT
CTCTTCTGGCCCCAGCAGTTGAGATGGCCACGTCCTCTGGGGGCTTCGGTGCCTTTGCCTTCTTCCCTGTGGCTGTTGGCTTCACCCTTG
GAGCGGCTTTTGTCTACTTGGCTGACCTCCTGATGCCTCACTTGGGTGCAGCAGAAGACCCCCAGACGACCCTGGCACTGAACTTCGGCT
CTACGTTGATGAAGAAGAAGTCTGATCCTGAGGGTCCCGCGCTGCTCTTCCCTGAGAGTGAACTTTCCATCCGGATAGGTAGAGCTGGGC
TTCTTTCAGACAAGAGTGAGAATGGTGAGGCATATCAGAGAAAGAAGGCGGCAGCCACTGGCCTTCCAGAGGGTCCTGCTGTCCCTGTGC
CTTCTCGAGGGAATCTGGCACAGCCCGGCGGCAGCAGCTGGAGGAGGATCGCACTGCTCATCTTGGCCATCACTATACACAACGTTCCAG
AGGGTCTCGCTGTTGGAGTTGGATTTGGGGCTATAGAAAAGACGGCATCTGCTACCTTTGAGAGTGCCAGGAATTTGGCCATTGGAATCG
GGATCCAGAATTTCCCCGAGGGCCTGGCTGTCAGCCTTCCCTTGCGAGGGGCAGGCTTCTCCACCTGGAGAGCTTTCTGGTATGGGCAGC
TGAGCGGCATGGTGGAGCCCCTGGCCGGGGTCTTTGGTGCCTTTGCCGTGGTGCTGGCTGAGCCCATCCTGCCCTACGCTCTGGCCTTTG
CTGCCGGTGCCATGGTCTACGTGGTCATGGACGACATCATCCCCGAAGCCCAGATCAGTGGTAATGGGAAACTGGCATCCTGGGCCTCCA
TCCTGGGATTTGTAGTGATGATGTCACTGGACGTTGGCCTGGGCTAGGGCTGAGACGCTTCGGACCCCGGGAAAGGCCATACGAAGAAAC
AGCAGTGGTTGGCTTCTATGGGACAACAAGCTTCTTTCTTCACATTAAAACTTTTTTCCTTCCTCTCTTCTTCATCTCATTATCCTGATT
GACTCTGATTATAATAGAACCATTTTTACTTTGCTTTGAGGGAGATTTTTGATTTAATGGGGAATTTTAAGGTGTCATGGAAATACAGAT
TCTTTGTTTTGGCCACTGAATGGACTCTCTCTTCAGTGGGATTATCAAGGAACTTCAGATCAGGGAAATCTCCACTTCGGGACCTTCTAT
CTGCCTCCCAACTCCTCAAGGTCACCTATAGAAGCGAGCTACCAAAAGACGTCTCCTAAGCATTTTGGTGGCCTAGTGACTCAGGGCAGA
GTGGCCAGCACACCTCTCATCCGCCCCTCCTGCTCCATCACTGCTGAGCCTCTCCCCATCTAGAATGTTGGAACTGGAGCATCATAAAGA
TAGCAAGCTACCTTCCAAGGCCGAGCCAGCCCAGAGAGGAGCATGTCTTCCTTTACCTCCCCCTAAGGAGATACTACATGGGAGGGGGAC
ACAGAAAAAGGGAAGGAAATTGGCTAGTCTGGCTTTTTTTTTTTTTTTTTTTAAAGGCAAAGATTGACATTATTGAAGGAAAGGGGATGA
GGACAACTGTGAACTCACAGTGAGCCCTGTGGAAAGAAGAGACAGACAGAGTGTGGGTTTGTTCGGAGGCCTCTGCTGTCAATGGATTCC
AGGAGCAAGGCCATTTGTCGCGCTTTCCAAATTTCTTAGGCATTTATTTTGATAAGTTTATAGCCATCATGTTTCTAAGAGACTTGGAGA
CACCAGCAAACTGCTAGAACTCAAACTCTTCAATTACTCAAAGAAGGAGCCATTTCAGTTAACTCAAGTGAATGAAAGAGTTTTGGAATC
TGCTGTGGGTCCTTCCCTGTTGACCATTTGGTAACTTATAATCTGACAAAAACTCTTGAGCTGCAACAGGCCTTGCCAGAGGGCTCAGGA
TGGGAAAGGAAGAAGGGGATAGGAAAAGAAGAGGTAATTTTACATTTCCCCTTTAAAGTAAATTTTAGCCAACTCATCATTCTGAAATGT
CCCTATAAAGAATGAGTCGAACTAGACCAGAAGCCAGCCTACTCCTTCTTACATAGCTTCTCCAACAGGGGTAGCAATGACCTGTCCACT
TCAAACACAGATAAGGCCTGCCATCCTCATTGGTTAAAGGCACACGTGAGACTTTCAGTGGGCTCTGCTGAGAAGGAAGGCAGCCCAGGA
GTCAGGTATGCAGGCATTGCATTGTCAGTGTCTGCTCTCAGAGTTTACACATTCAATTGCTTCCAAGGGTGAATCTCCTGCTCTGTGAAT
GCTATCAGACCCCAAAGGCCAACCTTGGGCTGGGTCTATGTACGTTCTTCCGAAGCACTGATGATCAAAATTGAAGACACATTCAGAGGT
TTGATTGGTTGAGATTAACTGGTGTGGTGGTTGGTGTATGTATGTTTTATTTTTATGTCTTTGTATGTAGTTCTACATAATGCAAATTGT

>55331_55331_4_MSI2-SLC39A11_MSI2_chr17_55339553_ENST00000322684_SLC39A11_chr17_71027853_ENST00000542342_length(amino acids)=393AA_BP=100
MADLTSVLTSVMFSPSSKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPK
VAFPRRAQPKVMLAASYWSLLAPAVEMATSSGGFGAFAFFPVAVGFTLGAAFVYLADLLMPHLGAAEDPQTTLALNFGSTLMKKKSDPEG
PALLFPESELSIRIGRAGLLSDKSENGEAYQRKKAAATGLPEGPAVPVPSRGNLAQPGGSSWRRIALLILAITIHNVPEGLAVGVGFGAI
EKTASATFESARNLAIGIGIQNFPEGLAVSLPLRGAGFSTWRAFWYGQLSGMVEPLAGVFGAFAVVLAEPILPYALAFAAGAMVYVVMDD

--------------------------------------------------------------
>55331_55331_5_MSI2-SLC39A11_MSI2_chr17_55339553_ENST00000416426_SLC39A11_chr17_71027853_ENST00000255559_length(transcript)=2877nt_BP=381nt
AGAGCCAGAGAGAACTTCCAGCGCAAAAGGAAAATAAAACTTGTGGCTGGTGTTTGTGCAGGAGGGTCTCCGCCATCCTGAAGCCCCCCG
ATCCTGGGGCGTCTCGGGGGCCGCCAAAGGAGCGCCAGGGTTAAAATGTTTATCGGTGGACTGAGCTGGCAGACCTCACCAGATAGCCTT
AGAGACTATTTTAGCAAATTTGGAGAAATTAGAGAATGTATGGTCATGAGAGATCCCACTACGAAACGCTCCAGAGGCTTCGGTTTCGTC
ACGTTCGCAGACCCAGCAAGTGTAGATAAAGTATTAGGTCAGCCCCACCATGAGTTAGATTCCAAGACGATTGACCCCAAAGTTGCATTT
CCTCGTCGAGCGCAACCCAAGGTCATGTTGGCAGCTTCCTATTGGTCTCTTCTGGCCCCAGCAGTTGAGATGGCCACGTCCTCTGGGGGC
TTCGGTGCCTTTGCCTTCTTCCCTGTGGCTGTTGGCTTCACCCTTGGAGCGGCTTTTGTCTACTTGGCTGACCTCCTGATGCCTCACTTG
GGTGCAGCAGAAGACCCCCAGACGACCCTGGCACTGAACTTCGGCTCTACGTTGATGAAGAAGAAGTCTGATCCTGAGGGTCCCGCGCTG
CTCTTCCCTGAGAGTGAACTTTCCATCCGGATAGACAAGAGTGAGAATGGTGAGGCATATCAGAGAAAGAAGGCGGCAGCCACTGGCCTT
CCAGAGGGTCCTGCTGTCCCTGTGCCTTCTCGAGGGAATCTGGCACAGCCCGGCGGCAGCAGCTGGAGGAGGATCGCACTGCTCATCTTG
GCCATCACTATACACAACGTTCCAGAGGGTCTCGCTGTTGGAGTTGGATTTGGGGCTATAGAAAAGACGGCATCTGCTACCTTTGAGAGT
GCCAGGAATTTGGCCATTGGAATCGGGATCCAGAATTTCCCCGAGGGCCTGGCTGTCAGCCTTCCCTTGCGAGGGGCAGGCTTCTCCACC
TGGAGAGCTTTCTGGTATGGGCAGCTGAGCGGCATGGTGGAGCCCCTGGCCGGGGTCTTTGGTGCCTTTGCCGTGGTGCTGGCTGAGCCC
ATCCTGCCCTACGCTCTGGCCTTTGCTGCCGGTGCCATGGTCTACGTGGTCATGGACGACATCATCCCCGAAGCCCAGATCAGTGGTAAT
GGGAAACTGGCATCCTGGGCCTCCATCCTGGGATTTGTAGTGATGATGTCACTGGACGTTGGCCTGGGCTAGGGCTGAGACGCTTCGGAC
CCCGGGAAAGGCCATACGAAGAAACAGCAGTGGTTGGCTTCTATGGGACAACAAGCTTCTTTCTTCACATTAAAACTTTTTTCCTTCCTC
TCTTCTTCATCTCATTATCCTGATTGACTCTGATTATAATAGAACCATTTTTACTTTGCTTTGAGGGAGATTTTTGATTTAATGGGGAAT
TTTAAGGTGTCATGGAAATACAGATTCTTTGTTTTGGCCACTGAATGGACTCTCTCTTCAGTGGGATTATCAAGGAACTTCAGATCAGGG
AAATCTCCACTTCGGGACCTTCTATCTGCCTCCCAACTCCTCAAGGTCACCTATAGAAGCGAGCTACCAAAAGACGTCTCCTAAGCATTT
TGGTGGCCTAGTGACTCAGGGCAGAGTGGCCAGCACACCTCTCATCCGCCCCTCCTGCTCCATCACTGCTGAGCCTCTCCCCATCTAGAA
TGTTGGAACTGGAGCATCATAAAGATAGCAAGCTACCTTCCAAGGCCGAGCCAGCCCAGAGAGGAGCATGTCTTCCTTTACCTCCCCCTA
AGGAGATACTACATGGGAGGGGGACACAGAAAAAGGGAAGGAAATTGGCTAGTCTGGCTTTTTTTTTTTTTTTTTTTAAAGGCAAAGATT
GACATTATTGAAGGAAAGGGGATGAGGACAACTGTGAACTCACAGTGAGCCCTGTGGAAAGAAGAGACAGACAGAGTGTGGGTTTGTTCG
GAGGCCTCTGCTGTCAATGGATTCCAGGAGCAAGGCCATTTGTCGCGCTTTCCAAATTTCTTAGGCATTTATTTTGATAAGTTTATAGCC
ATCATGTTTCTAAGAGACTTGGAGACACCAGCAAACTGCTAGAACTCAAACTCTTCAATTACTCAAAGAAGGAGCCATTTCAGTTAACTC
AAGTGAATGAAAGAGTTTTGGAATCTGCTGTGGGTCCTTCCCTGTTGACCATTTGGTAACTTATAATCTGACAAAAACTCTTGAGCTGCA
ACAGGCCTTGCCAGAGGGCTCAGGATGGGAAAGGAAGAAGGGGATAGGAAAAGAAGAGGTAATTTTACATTTCCCCTTTAAAGTAAATTT
TAGCCAACTCATCATTCTGAAATGTCCCTATAAAGAATGAGTCGAACTAGACCAGAAGCCAGCCTACTCCTTCTTACATAGCTTCTCCAA
CAGGGGTAGCAATGACCTGTCCACTTCAAACACAGATAAGGCCTGCCATCCTCATTGGTTAAAGGCACACGTGAGACTTTCAGTGGGCTC
TGCTGAGAAGGAAGGCAGCCCAGGAGTCAGGTATGCAGGCATTGCATTGTCAGTGTCTGCTCTCAGAGTTTACACATTCAATTGCTTCCA
AGGGTGAATCTCCTGCTCTGTGAATGCTATCAGACCCCAAAGGCCAACCTTGGGCTGGGTCTATGTACGTTCTTCCGAAGCACTGATGAT
CAAAATTGAAGACACATTCAGAGGTTTGATTGGTTGAGATTAACTGGTGTGGTGGTTGGTGTATGTATGTTTTATTTTTATGTCTTTGTA

>55331_55331_5_MSI2-SLC39A11_MSI2_chr17_55339553_ENST00000416426_SLC39A11_chr17_71027853_ENST00000255559_length(amino acids)=382AA_BP=96
MGRLGGRQRSARVKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFP
RRAQPKVMLAASYWSLLAPAVEMATSSGGFGAFAFFPVAVGFTLGAAFVYLADLLMPHLGAAEDPQTTLALNFGSTLMKKKSDPEGPALL
FPESELSIRIDKSENGEAYQRKKAAATGLPEGPAVPVPSRGNLAQPGGSSWRRIALLILAITIHNVPEGLAVGVGFGAIEKTASATFESA
RNLAIGIGIQNFPEGLAVSLPLRGAGFSTWRAFWYGQLSGMVEPLAGVFGAFAVVLAEPILPYALAFAAGAMVYVVMDDIIPEAQISGNG

--------------------------------------------------------------
>55331_55331_6_MSI2-SLC39A11_MSI2_chr17_55339553_ENST00000416426_SLC39A11_chr17_71027853_ENST00000542342_length(transcript)=2897nt_BP=381nt
AGAGCCAGAGAGAACTTCCAGCGCAAAAGGAAAATAAAACTTGTGGCTGGTGTTTGTGCAGGAGGGTCTCCGCCATCCTGAAGCCCCCCG
ATCCTGGGGCGTCTCGGGGGCCGCCAAAGGAGCGCCAGGGTTAAAATGTTTATCGGTGGACTGAGCTGGCAGACCTCACCAGATAGCCTT
AGAGACTATTTTAGCAAATTTGGAGAAATTAGAGAATGTATGGTCATGAGAGATCCCACTACGAAACGCTCCAGAGGCTTCGGTTTCGTC
ACGTTCGCAGACCCAGCAAGTGTAGATAAAGTATTAGGTCAGCCCCACCATGAGTTAGATTCCAAGACGATTGACCCCAAAGTTGCATTT
CCTCGTCGAGCGCAACCCAAGGTCATGTTGGCAGCTTCCTATTGGTCTCTTCTGGCCCCAGCAGTTGAGATGGCCACGTCCTCTGGGGGC
TTCGGTGCCTTTGCCTTCTTCCCTGTGGCTGTTGGCTTCACCCTTGGAGCGGCTTTTGTCTACTTGGCTGACCTCCTGATGCCTCACTTG
GGTGCAGCAGAAGACCCCCAGACGACCCTGGCACTGAACTTCGGCTCTACGTTGATGAAGAAGAAGTCTGATCCTGAGGGTCCCGCGCTG
CTCTTCCCTGAGAGTGAACTTTCCATCCGGATAGGTAGAGCTGGGCTTCTTTCAGACAAGAGTGAGAATGGTGAGGCATATCAGAGAAAG
AAGGCGGCAGCCACTGGCCTTCCAGAGGGTCCTGCTGTCCCTGTGCCTTCTCGAGGGAATCTGGCACAGCCCGGCGGCAGCAGCTGGAGG
AGGATCGCACTGCTCATCTTGGCCATCACTATACACAACGTTCCAGAGGGTCTCGCTGTTGGAGTTGGATTTGGGGCTATAGAAAAGACG
GCATCTGCTACCTTTGAGAGTGCCAGGAATTTGGCCATTGGAATCGGGATCCAGAATTTCCCCGAGGGCCTGGCTGTCAGCCTTCCCTTG
CGAGGGGCAGGCTTCTCCACCTGGAGAGCTTTCTGGTATGGGCAGCTGAGCGGCATGGTGGAGCCCCTGGCCGGGGTCTTTGGTGCCTTT
GCCGTGGTGCTGGCTGAGCCCATCCTGCCCTACGCTCTGGCCTTTGCTGCCGGTGCCATGGTCTACGTGGTCATGGACGACATCATCCCC
GAAGCCCAGATCAGTGGTAATGGGAAACTGGCATCCTGGGCCTCCATCCTGGGATTTGTAGTGATGATGTCACTGGACGTTGGCCTGGGC
TAGGGCTGAGACGCTTCGGACCCCGGGAAAGGCCATACGAAGAAACAGCAGTGGTTGGCTTCTATGGGACAACAAGCTTCTTTCTTCACA
TTAAAACTTTTTTCCTTCCTCTCTTCTTCATCTCATTATCCTGATTGACTCTGATTATAATAGAACCATTTTTACTTTGCTTTGAGGGAG
ATTTTTGATTTAATGGGGAATTTTAAGGTGTCATGGAAATACAGATTCTTTGTTTTGGCCACTGAATGGACTCTCTCTTCAGTGGGATTA
TCAAGGAACTTCAGATCAGGGAAATCTCCACTTCGGGACCTTCTATCTGCCTCCCAACTCCTCAAGGTCACCTATAGAAGCGAGCTACCA
AAAGACGTCTCCTAAGCATTTTGGTGGCCTAGTGACTCAGGGCAGAGTGGCCAGCACACCTCTCATCCGCCCCTCCTGCTCCATCACTGC
TGAGCCTCTCCCCATCTAGAATGTTGGAACTGGAGCATCATAAAGATAGCAAGCTACCTTCCAAGGCCGAGCCAGCCCAGAGAGGAGCAT
GTCTTCCTTTACCTCCCCCTAAGGAGATACTACATGGGAGGGGGACACAGAAAAAGGGAAGGAAATTGGCTAGTCTGGCTTTTTTTTTTT
TTTTTTTTAAAGGCAAAGATTGACATTATTGAAGGAAAGGGGATGAGGACAACTGTGAACTCACAGTGAGCCCTGTGGAAAGAAGAGACA
GACAGAGTGTGGGTTTGTTCGGAGGCCTCTGCTGTCAATGGATTCCAGGAGCAAGGCCATTTGTCGCGCTTTCCAAATTTCTTAGGCATT
TATTTTGATAAGTTTATAGCCATCATGTTTCTAAGAGACTTGGAGACACCAGCAAACTGCTAGAACTCAAACTCTTCAATTACTCAAAGA
AGGAGCCATTTCAGTTAACTCAAGTGAATGAAAGAGTTTTGGAATCTGCTGTGGGTCCTTCCCTGTTGACCATTTGGTAACTTATAATCT
GACAAAAACTCTTGAGCTGCAACAGGCCTTGCCAGAGGGCTCAGGATGGGAAAGGAAGAAGGGGATAGGAAAAGAAGAGGTAATTTTACA
TTTCCCCTTTAAAGTAAATTTTAGCCAACTCATCATTCTGAAATGTCCCTATAAAGAATGAGTCGAACTAGACCAGAAGCCAGCCTACTC
CTTCTTACATAGCTTCTCCAACAGGGGTAGCAATGACCTGTCCACTTCAAACACAGATAAGGCCTGCCATCCTCATTGGTTAAAGGCACA
CGTGAGACTTTCAGTGGGCTCTGCTGAGAAGGAAGGCAGCCCAGGAGTCAGGTATGCAGGCATTGCATTGTCAGTGTCTGCTCTCAGAGT
TTACACATTCAATTGCTTCCAAGGGTGAATCTCCTGCTCTGTGAATGCTATCAGACCCCAAAGGCCAACCTTGGGCTGGGTCTATGTACG
TTCTTCCGAAGCACTGATGATCAAAATTGAAGACACATTCAGAGGTTTGATTGGTTGAGATTAACTGGTGTGGTGGTTGGTGTATGTATG
TTTTATTTTTATGTCTTTGTATGTAGTTCTACATAATGCAAATTGTGCTTTCTGATGGACAAGACCTCATAACTGTGATTAATATCAATA

>55331_55331_6_MSI2-SLC39A11_MSI2_chr17_55339553_ENST00000416426_SLC39A11_chr17_71027853_ENST00000542342_length(amino acids)=389AA_BP=96
MGRLGGRQRSARVKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFP
RRAQPKVMLAASYWSLLAPAVEMATSSGGFGAFAFFPVAVGFTLGAAFVYLADLLMPHLGAAEDPQTTLALNFGSTLMKKKSDPEGPALL
FPESELSIRIGRAGLLSDKSENGEAYQRKKAAATGLPEGPAVPVPSRGNLAQPGGSSWRRIALLILAITIHNVPEGLAVGVGFGAIEKTA
SATFESARNLAIGIGIQNFPEGLAVSLPLRGAGFSTWRAFWYGQLSGMVEPLAGVFGAFAVVLAEPILPYALAFAAGAMVYVVMDDIIPE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MSI2-SLC39A11

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MSI2-SLC39A11

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MSI2-SLC39A11

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source