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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MSI2-TRIM25 (FusionGDB2 ID:55336)

Fusion Gene Summary for MSI2-TRIM25

check button Fusion gene summary
Fusion gene informationFusion gene name: MSI2-TRIM25
Fusion gene ID: 55336
HgeneTgene
Gene symbol

MSI2

TRIM25

Gene ID

124540

7706

Gene namemusashi RNA binding protein 2tripartite motif containing 25
SynonymsMSI2HEFP|RNF147|Z147|ZNF147
Cytomap

17q22

17q22

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein Musashi homolog 2musashi homolog 2musashi-2E3 ubiquitin/ISG15 ligase TRIM25RING finger protein 147RING-type E3 ubiquitin transferaseRING-type E3 ubiquitin transferase TRIM25estrogen-responsive finger proteintripartite motif protein TRIM25tripartite motif-containing protein 25ubiquitin/ISG15
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000284073, ENST00000322684, 
ENST00000416426, ENST00000442934, 
ENST00000579180, ENST00000579505, 
ENST00000537230, ENST00000573108, 
ENST00000316881, 
Fusion gene scores* DoF score40 X 16 X 16=102406 X 7 X 2=84
# samples 457
** MAII scorelog2(45/10240*10)=-4.50814690367033
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MSI2 [Title/Abstract] AND TRIM25 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRIM25(54972704)-MSI2(55674229), # samples:2
TRIM25(54972704)-MSI2(55607037), # samples:2
MSI2(55339553)-TRIM25(54985924), # samples:1
Anticipated loss of major functional domain due to fusion event.TRIM25-MSI2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
TRIM25-MSI2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTRIM25

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

23077300

TgeneTRIM25

GO:0043627

response to estrogen

22452784

TgeneTRIM25

GO:0045087

innate immune response

18248090

TgeneTRIM25

GO:0046596

regulation of viral entry into host cell

18248090


check buttonFusion gene breakpoints across MSI2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TRIM25 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A12M-01AMSI2chr17

55339553

+TRIM25chr17

54985924

-


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Fusion Gene ORF analysis for MSI2-TRIM25

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000284073ENST00000537230MSI2chr17

55339553

+TRIM25chr17

54985924

-
5CDS-intronENST00000284073ENST00000573108MSI2chr17

55339553

+TRIM25chr17

54985924

-
5CDS-intronENST00000322684ENST00000537230MSI2chr17

55339553

+TRIM25chr17

54985924

-
5CDS-intronENST00000322684ENST00000573108MSI2chr17

55339553

+TRIM25chr17

54985924

-
5CDS-intronENST00000416426ENST00000537230MSI2chr17

55339553

+TRIM25chr17

54985924

-
5CDS-intronENST00000416426ENST00000573108MSI2chr17

55339553

+TRIM25chr17

54985924

-
In-frameENST00000284073ENST00000316881MSI2chr17

55339553

+TRIM25chr17

54985924

-
In-frameENST00000322684ENST00000316881MSI2chr17

55339553

+TRIM25chr17

54985924

-
In-frameENST00000416426ENST00000316881MSI2chr17

55339553

+TRIM25chr17

54985924

-
intron-3CDSENST00000442934ENST00000316881MSI2chr17

55339553

+TRIM25chr17

54985924

-
intron-3CDSENST00000579180ENST00000316881MSI2chr17

55339553

+TRIM25chr17

54985924

-
intron-3CDSENST00000579505ENST00000316881MSI2chr17

55339553

+TRIM25chr17

54985924

-
intron-intronENST00000442934ENST00000537230MSI2chr17

55339553

+TRIM25chr17

54985924

-
intron-intronENST00000442934ENST00000573108MSI2chr17

55339553

+TRIM25chr17

54985924

-
intron-intronENST00000579180ENST00000537230MSI2chr17

55339553

+TRIM25chr17

54985924

-
intron-intronENST00000579180ENST00000573108MSI2chr17

55339553

+TRIM25chr17

54985924

-
intron-intronENST00000579505ENST00000537230MSI2chr17

55339553

+TRIM25chr17

54985924

-
intron-intronENST00000579505ENST00000573108MSI2chr17

55339553

+TRIM25chr17

54985924

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000416426MSI2chr1755339553+ENST00000316881TRIM25chr1754985924-5468381931676527
ENST00000284073MSI2chr1755339553+ENST00000316881TRIM25chr1754985924-56085211791816545
ENST00000322684MSI2chr1755339553+ENST00000316881TRIM25chr1754985924-5422335351630531

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000416426ENST00000316881MSI2chr1755339553+TRIM25chr1754985924-0.0016165150.9983835
ENST00000284073ENST00000316881MSI2chr1755339553+TRIM25chr1754985924-0.0015690280.9984309
ENST00000322684ENST00000316881MSI2chr1755339553+TRIM25chr1754985924-0.0013859660.9986141

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Fusion Genomic Features for MSI2-TRIM25


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MSI2-TRIM25


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:54972704/chr17:55674229)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTRIM25chr17:55339553chr17:54985924ENST0000031688109217_307199631.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM25chr17:55339553chr17:54985924ENST00000537230010217_307199684.3333333333334Coiled coilOntology_term=ECO:0000255
TgeneTRIM25chr17:55339553chr17:54985924ENST0000031688109439_630199631.0DomainB30.2/SPRY
TgeneTRIM25chr17:55339553chr17:54985924ENST00000537230010439_630199684.3333333333334DomainB30.2/SPRY

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMSI2chr17:55339553chr17:54985924ENST00000284073+514253_2601041951.0Compositional biasNote=Poly-Ala
HgeneMSI2chr17:55339553chr17:54985924ENST00000322684+410253_260100252.0Compositional biasNote=Poly-Ala
HgeneMSI2chr17:55339553chr17:54985924ENST00000579180+17253_2600152.0Compositional biasNote=Poly-Ala
HgeneMSI2chr17:55339553chr17:54985924ENST00000284073+514110_1871041951.0DomainRRM 2
HgeneMSI2chr17:55339553chr17:54985924ENST00000284073+51421_1111041951.0DomainRRM 1
HgeneMSI2chr17:55339553chr17:54985924ENST00000322684+410110_187100252.0DomainRRM 2
HgeneMSI2chr17:55339553chr17:54985924ENST00000322684+41021_111100252.0DomainRRM 1
HgeneMSI2chr17:55339553chr17:54985924ENST00000579180+17110_1870152.0DomainRRM 2
HgeneMSI2chr17:55339553chr17:54985924ENST00000579180+1721_1110152.0DomainRRM 1
TgeneTRIM25chr17:55339553chr17:54985924ENST000003168810913_54199631.0Zinc fingerRING-type
TgeneTRIM25chr17:55339553chr17:54985924ENST0000053723001013_54199684.3333333333334Zinc fingerRING-type


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Fusion Gene Sequence for MSI2-TRIM25


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>55336_55336_1_MSI2-TRIM25_MSI2_chr17_55339553_ENST00000284073_TRIM25_chr17_54985924_ENST00000316881_length(transcript)=5608nt_BP=521nt
CGGGGCTGAGCTAAGCCGAGCCCACGTGTGACGGCTCTCGCCGCTGCCCCGGCTCCGCCGCTCGCAGAGAGATTCGGAGGAGCCCGGGCG
GGGGGGAGGAGGAGGGGGAGGAGGGAGCGGAGATCTCGGGGCTCGGAGCCGGCCGCCGCTCCGCTCCGATCGCTGTGGGGCTTGGTTTTT
TGGGGGTGGGGGGGCGGGGGGGCTCAGATATGGAGGCAAATGGGAGCCAAGGCACCTCGGGCAGCGCCAACGACTCCCAGCACGACCCCG
GTAAAATGTTTATCGGTGGACTGAGCTGGCAGACCTCACCAGATAGCCTTAGAGACTATTTTAGCAAATTTGGAGAAATTAGAGAATGTA
TGGTCATGAGAGATCCCACTACGAAACGCTCCAGAGGCTTCGGTTTCGTCACGTTCGCAGACCCAGCAAGTGTAGATAAAGTATTAGGTC
AGCCCCACCATGAGTTAGATTCCAAGACGATTGACCCCAAAGTTGCATTTCCTCGTCGAGCGCAACCCAAGGCCACCCTGAGGCACAAAC
TAACTGTCATGTACAGTCAGATCAACGGGGCGTCGAGAGCACTGGATGATGTGAGAAACAGGCAGCAGGATGTGCGGATGACTGCAAACA
GAAAGGTGGAGCAGCTACAACAAGAATACACGGAAATGAAGGCTCTCTTGGACGCCTCAGAGACCACCTCGACAAGGAAGATAAAGGAAG
AGGAGAAGAGGGTCAACAGCAAGTTTGACACCATTTATCAGATTCTCCTCAAGAAGAAGAGTGAGATCCAGACCTTGAAGGAGGAGATTG
AACAGAGCCTGACCAAGAGGGATGAGTTCGAGTTTCTGGAGAAAGCATCAAAACTGCGAGGAATCTCAACAAAGCCAGTCTACATCCCCG
AGGTGGAACTGAACCACAAGCTGATAAAAGGCATCCACCAGAGCACCATAGACCTCAAAAACGAGCTGAAGCAGTGCATCGGGCGGCTCC
AGGAGCCCACCCCCAGTTCAGGTGACCCTGGAGAGCATGACCCAGCGTCCACACACAAATCCACACGCCCTGTGAAGAAGGTCTCCAAAG
AGGAAAAGAAATCCAAGAAACCTCCCCCTGTCCCTGCCTTACCCAGCAAGCTTCCCACGTTTGGAGCCCCGGAACAGTTAGTGGATTTAA
AACAAGCTGGCTTGGAGGCTGCAGCCAAAGCCACCAGCTCACATCCGAACTCAACATCTCTCAAGGCCAAGGTGCTGGAGACCTTCCTGG
CCAAGTCCAGACCTGAGCTCCTGGAGTATTACATTAAAGTCATCCTGGACTACAACACCGCCCACAACAAAGTGGCTCTGTCAGAGTGCT
ATACAGTAGCTTCTGTGGCTGAGATGCCTCAGAACTACCGGCCGCATCCCCAGAGGTTCACATACTGCTCTCAGGTGCTGGGCCTGCACT
GCTACAAGAAGGGGATCCACTACTGGGAGGTGGAGCTGCAGAAGAACAACTTCTGTGGGGTAGGCATCTGCTACGGAAGCATGAACCGGC
AGGGCCCAGAAAGCAGGCTCGGCCGCAACAGCGCCTCCTGGTGCGTGGAGTGGTTCAACACCAAGATCTCTGCCTGGCACAATAACGTGG
AGAAAACCCTGCCCTCCACCAAGGCCACGCGGGTGGGCGTGCTTCTCAACTGTGACCACGGCTTTGTCATCTTCTTCGCTGTTGCCGACA
AGGTCCACCTGATGTATAAGTTCAGGGTGGACTTTACTGAGGCTTTGTACCCGGCTTTCTGGGTATTTTCTGCTGGTGCCACACTCTCCA
TCTGCTCCCCCAAGTAGGCAGGCTGTAGGCACTTGGGCTGACTGCCTGCAGAAGTCCCAAGACCCTAGTGAAAATACAGCAGGCAGAACT
CTCCTTGGATAATTCCCCAAGAGGTCCCAAGGATTGGGAGCATGGGAGGGGAGCTGGCGGGAGGGTGGGAGGTGGGATTTAGCCAGGAAA
GGGGTGAGAGTGATTGTGTTGTGGGCGAGGAGGCGTTTCCACCCCCTGGTGCCTATCAGGGCAGGGTGACCTACTCCCCATTGTTCTGGA
AATCTCCAGGCTGCTGGGCAGCTGGGCAGAGCTCTGGGAAGTGAAGTCATGAGTGCCCGATTCCTCTTAGAGAAAATCCATAGCTACTGT
AGGTTCTGTCTTGGGCCACTTGGATCTGAAGGCTGCCCCTTTGCTCTCTGGGGTAGCCTTCAGATCTTGGTGTTTTGAATTCTTACTATA
GATGTTTTTAAAGTTCCAAAGTCATTGAGTTTCAATGTTACATAAACTCCATTACCCGCATGTTGGGGCTTGATCTCCTGGTTATTATCT
GTGCTTGAGGAAACACCCACAGCAGTCTCTACCCAGAACAGTTTCCTAAAGAGGCATACCCTCTTCCTCCACTGGAAAATAGTGCGTTCC
CTTCCTACCCTGCACACCCATCGCCCCCACATTGATGGTTTTCAAACAGCAAACTTTTCAGCTAAAGCTTCAAACCATGATTGGAATCAG
CCTGTGTTGGATTTGTGATTCAGGGTCATGGTGACCCTGATCCAGTTTGGGTGGAAATCCTTCCTAAGTATCATAAGAAGCATCTTGGCA
GAGATGCTTTGGTGGCAGCCATGAGCTTTGCTGGAGGCCTTGCTTCCCATAGCCTTGGCTGTGGGGCAAGGAACTCTGCCAGGCGAGGGG
GATGCTGCCCTGGATCAACAGAAGCCTGGTGGGTTTGCTCGTGTTAGAGTGTCCTGCCTTCTTACTGACAACTCTTCTCGGTGATAGCCT
CTCTTCCCTGGATTGTGACATATGGAATGACAGTGCAGGTACCACCGAGGCTAGCACAGTCAAGCCTCCAGCTAAGCTGGATCCCTGAAG
CCTGCTATCATGCAGACAGGCTATGCGGCTGCCTCGGACCATGCTAGGCCACTTGCTGGGGTGTCAACCTACCACCAAAGGGGTCTTTTA
GCAAACCTCATGGGGAACAGGAACATTCCTGTTCATCCCTGGCCACAGGCTGCAGACCCAGCACTGGCCCTTGCGTGAGTCAGAGCCTGG
GGCTGGCCCTAGCCCCTTCTACTGACTTCCTCATTTAAGCCAATTATATAAGCTCACATTGATCAGGGAGGGAGGGAAAGAGCTAAAGAG
GGTCACACAAGTGGCTATTTTCCCTGCAGTGTTTCTGTGTGGTGAAAATAACCCAGTCCACTAAGGGGCGGGAGTGAATGGATGGCTGGA
TTTTCCCCAAGCTCCTTATAGCCTAATGTTGTCAGGATGTGAGTATGAGGAATTTAGCCTCTTATAGTGAAATGAGTCCAACTCTGGGCT
TTGCTTAGAGGAGAGCTCCTGTCAGGCTTCCTATAATATGAAAAGAAGTCACCATTGGGGAACTAGAGACCCCAGACCTTTTCATATGGA
TATTTGAGAATGTAATGCATCTCAGGCCTCGTGCTGGAACTCTAGGGCACTCTAGGCAGGCTCAGAACACTTGATATTCCTGACAGCTAC
ACACCTGACATGCAGGTACATACCTGATCGGTGTCATCTCCTAACAAGGATTTTCAGTTCCTCGGGAGAGCAATAATCTTTGTAGGAAAG
ACATCCCTGCAATAGGTGATATGTGGTCCTTAGAAGTTTTATTCCTTTACTACTTGGAAGAAAAGTTCTTTGGTGATTCTTCTCTGCTTT
TGAAGATGATCAAAAGCATCTTCATTGATTTTCTGAAACGAAAGCCTTGTCTGAAACCAATTAATACTTGGGAAACAGCTGGGCTTGGAG
GAGTAGAATGCCAGAGATAAATCCATGGCTCCTGCTCTGGCTCTCTTCTGCAGAAATGAGGGCAACAGTGAGGCCACTTCCCTGGCAAAT
GTGCAGCTCAGGATAGGGAAGCATAAGACCCTCTGTTTAAAAGAGAGTCAAGTAGGTAACCAAAGCCAAGCTCTGTGCAAGGTGCTTTGG
AGTTGTAAATTGAGGAGTGCATCCTTGCTGTCTTGAACCATTCTGTTTGCAATGGTGAGACCTTACATAACCTAGCCTTGCAGGGCCGCC
ACACAACCCTGGAGTCCTAGAGTTGGAGGAACCTTTGTATCCATCTGACTTCTCATTTTGCAGAATATGATGAGAAAGTAGAGGATCGCT
CTGTTCACCACTCTTGCTATTCCATTAGTGGGGAGATGCCTGCTAGCATGTGTGAGGGGAACACTCTGATACACTGGGAAGTATCGGAAA
TTCCCAGAAACACAAACATAAAATAACTCTCCTAGACCCAGGTACTGGGGACTGTCTCAGTCCGTGTGGCATGATAAATAAAAGGTTAGG
ATCAAGTCTTTGTATTTTTCAAGATGTGGTAGCTGATTATTCCTGTTTTAAGTACTCTGAAATTGATCTGTGATCAATAATACTAATATG
TTATCTTTTACCGTATTCTGCCTCTCACTATTGATTTTAATTAGTTAGGAGTATTTGAGCTGTTATTTCTTGAGCTTAATATTTTTTTAG
AGTTAACTCTTTAAGGAGATAATCATGGCTGTAGACAAGGCCAGGGCTGGCTGACGTGCCTTAGAAGGTTTGAATGCAATAAAGCGGTGT
TTGGCGTTCTCCTGCATTGTAGTGCGGGTACAAAATGCTATTTGTTCGTCATACTGTTGTCAGCAGATGAGCCGCCCACTACAGACGGCT
ACTGCCCAGGGACCTGCCCAGGCCCCACCCAAGGGCTCCCAAGGGTTGAGATTTCTGCAGACCTATAGCCAGCACACTTAGTCCTGCCCT
ATATAGAGTTCCTCTTCGGGAAGCTTTTGATAAGGAATTCTCAGACCGATAGGATGTCTGTCTGGGCTTTGCTGCGGGACAGTCTAACTG
TGGGGGCTAGGGGAAAGCAGGAGAGTATCGATCAAAGAGTAAGCCACACACGGATAATCAGTTACTAGGGATGGAGGTGTGAGGGTTCAT
TATATTATTCATTTTACTGTTGTATATGTTTGAAAATGTCTATAATAAAAAGCTTTAAAAAAAAAAAAGAAACAAAAATAGTTCAGGCCA
GCAATGGGCCCTCCATGTTCAGTGGATTTTATCCTTGTTTCAATTGGGGTAGGAGTTCCAGGAGGTGTGGATTGGAGGTTGTCTAAAGAA
TTGAACTGGCCTTTGTCCCTGCTTCCTGGGAGGGAGACTTTCAGTCCTTGACATTTCCAGGGTAATAGGAGTGTCTTTGTTATTTGTGAG
GCCATGGGATCACACCTGAGCTTATGCTAAAAGGTGGGATGACTCAGAGCTGGGGCTGGTCACCAGACAGACTGACCATGTGATTAGAGG
TTTGAGGCTTTGAGTCAGCCTGACCTATGGGGCGGGGGACTGGAGGCTGAGTTTAATCATCTGGCCAGTGCTTTAATCAGTACATCATGA
AACCCTAATAAAAACTCTGGACACTAAAGCTCAGCATAGCTTCCTGGGTGGTGAAGCTGTGGCTATGCCGGCAGGGCAGTGTGCCCTAAT
TCCACGAAGAGGGGGCATGGGAGCACTGTGCTCAAGACCCTTCCAGACCTTTCCCTGTGTCTTCCTTGGCTTGTGGAGCTGATTTGTATC

>55336_55336_1_MSI2-TRIM25_MSI2_chr17_55339553_ENST00000284073_TRIM25_chr17_54985924_ENST00000316881_length(amino acids)=545AA_BP=114
MGVGGRGGSDMEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLG
QPHHELDSKTIDPKVAFPRRAQPKATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQLQQEYTEMKALLDASETTSTRKIKE
EEKRVNSKFDTIYQILLKKKSEIQTLKEEIEQSLTKRDEFEFLEKASKLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRL
QEPTPSSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGLEAAAKATSSHPNSTSLKAKVLETFL
AKSRPELLEYYIKVILDYNTAHNKVALSECYTVASVAEMPQNYRPHPQRFTYCSQVLGLHCYKKGIHYWEVELQKNNFCGVGICYGSMNR
QGPESRLGRNSASWCVEWFNTKISAWHNNVEKTLPSTKATRVGVLLNCDHGFVIFFAVADKVHLMYKFRVDFTEALYPAFWVFSAGATLS

--------------------------------------------------------------
>55336_55336_2_MSI2-TRIM25_MSI2_chr17_55339553_ENST00000322684_TRIM25_chr17_54985924_ENST00000316881_length(transcript)=5422nt_BP=335nt
GCTTTCCTTTTAGCTTTTGTAAGTTACACGTCAAAATGGCCGATCTGACATCGGTGCTCACTTCTGTTATGTTTTCTCCCTCTAGTAAAA
TGTTTATCGGTGGACTGAGCTGGCAGACCTCACCAGATAGCCTTAGAGACTATTTTAGCAAATTTGGAGAAATTAGAGAATGTATGGTCA
TGAGAGATCCCACTACGAAACGCTCCAGAGGCTTCGGTTTCGTCACGTTCGCAGACCCAGCAAGTGTAGATAAAGTATTAGGTCAGCCCC
ACCATGAGTTAGATTCCAAGACGATTGACCCCAAAGTTGCATTTCCTCGTCGAGCGCAACCCAAGGCCACCCTGAGGCACAAACTAACTG
TCATGTACAGTCAGATCAACGGGGCGTCGAGAGCACTGGATGATGTGAGAAACAGGCAGCAGGATGTGCGGATGACTGCAAACAGAAAGG
TGGAGCAGCTACAACAAGAATACACGGAAATGAAGGCTCTCTTGGACGCCTCAGAGACCACCTCGACAAGGAAGATAAAGGAAGAGGAGA
AGAGGGTCAACAGCAAGTTTGACACCATTTATCAGATTCTCCTCAAGAAGAAGAGTGAGATCCAGACCTTGAAGGAGGAGATTGAACAGA
GCCTGACCAAGAGGGATGAGTTCGAGTTTCTGGAGAAAGCATCAAAACTGCGAGGAATCTCAACAAAGCCAGTCTACATCCCCGAGGTGG
AACTGAACCACAAGCTGATAAAAGGCATCCACCAGAGCACCATAGACCTCAAAAACGAGCTGAAGCAGTGCATCGGGCGGCTCCAGGAGC
CCACCCCCAGTTCAGGTGACCCTGGAGAGCATGACCCAGCGTCCACACACAAATCCACACGCCCTGTGAAGAAGGTCTCCAAAGAGGAAA
AGAAATCCAAGAAACCTCCCCCTGTCCCTGCCTTACCCAGCAAGCTTCCCACGTTTGGAGCCCCGGAACAGTTAGTGGATTTAAAACAAG
CTGGCTTGGAGGCTGCAGCCAAAGCCACCAGCTCACATCCGAACTCAACATCTCTCAAGGCCAAGGTGCTGGAGACCTTCCTGGCCAAGT
CCAGACCTGAGCTCCTGGAGTATTACATTAAAGTCATCCTGGACTACAACACCGCCCACAACAAAGTGGCTCTGTCAGAGTGCTATACAG
TAGCTTCTGTGGCTGAGATGCCTCAGAACTACCGGCCGCATCCCCAGAGGTTCACATACTGCTCTCAGGTGCTGGGCCTGCACTGCTACA
AGAAGGGGATCCACTACTGGGAGGTGGAGCTGCAGAAGAACAACTTCTGTGGGGTAGGCATCTGCTACGGAAGCATGAACCGGCAGGGCC
CAGAAAGCAGGCTCGGCCGCAACAGCGCCTCCTGGTGCGTGGAGTGGTTCAACACCAAGATCTCTGCCTGGCACAATAACGTGGAGAAAA
CCCTGCCCTCCACCAAGGCCACGCGGGTGGGCGTGCTTCTCAACTGTGACCACGGCTTTGTCATCTTCTTCGCTGTTGCCGACAAGGTCC
ACCTGATGTATAAGTTCAGGGTGGACTTTACTGAGGCTTTGTACCCGGCTTTCTGGGTATTTTCTGCTGGTGCCACACTCTCCATCTGCT
CCCCCAAGTAGGCAGGCTGTAGGCACTTGGGCTGACTGCCTGCAGAAGTCCCAAGACCCTAGTGAAAATACAGCAGGCAGAACTCTCCTT
GGATAATTCCCCAAGAGGTCCCAAGGATTGGGAGCATGGGAGGGGAGCTGGCGGGAGGGTGGGAGGTGGGATTTAGCCAGGAAAGGGGTG
AGAGTGATTGTGTTGTGGGCGAGGAGGCGTTTCCACCCCCTGGTGCCTATCAGGGCAGGGTGACCTACTCCCCATTGTTCTGGAAATCTC
CAGGCTGCTGGGCAGCTGGGCAGAGCTCTGGGAAGTGAAGTCATGAGTGCCCGATTCCTCTTAGAGAAAATCCATAGCTACTGTAGGTTC
TGTCTTGGGCCACTTGGATCTGAAGGCTGCCCCTTTGCTCTCTGGGGTAGCCTTCAGATCTTGGTGTTTTGAATTCTTACTATAGATGTT
TTTAAAGTTCCAAAGTCATTGAGTTTCAATGTTACATAAACTCCATTACCCGCATGTTGGGGCTTGATCTCCTGGTTATTATCTGTGCTT
GAGGAAACACCCACAGCAGTCTCTACCCAGAACAGTTTCCTAAAGAGGCATACCCTCTTCCTCCACTGGAAAATAGTGCGTTCCCTTCCT
ACCCTGCACACCCATCGCCCCCACATTGATGGTTTTCAAACAGCAAACTTTTCAGCTAAAGCTTCAAACCATGATTGGAATCAGCCTGTG
TTGGATTTGTGATTCAGGGTCATGGTGACCCTGATCCAGTTTGGGTGGAAATCCTTCCTAAGTATCATAAGAAGCATCTTGGCAGAGATG
CTTTGGTGGCAGCCATGAGCTTTGCTGGAGGCCTTGCTTCCCATAGCCTTGGCTGTGGGGCAAGGAACTCTGCCAGGCGAGGGGGATGCT
GCCCTGGATCAACAGAAGCCTGGTGGGTTTGCTCGTGTTAGAGTGTCCTGCCTTCTTACTGACAACTCTTCTCGGTGATAGCCTCTCTTC
CCTGGATTGTGACATATGGAATGACAGTGCAGGTACCACCGAGGCTAGCACAGTCAAGCCTCCAGCTAAGCTGGATCCCTGAAGCCTGCT
ATCATGCAGACAGGCTATGCGGCTGCCTCGGACCATGCTAGGCCACTTGCTGGGGTGTCAACCTACCACCAAAGGGGTCTTTTAGCAAAC
CTCATGGGGAACAGGAACATTCCTGTTCATCCCTGGCCACAGGCTGCAGACCCAGCACTGGCCCTTGCGTGAGTCAGAGCCTGGGGCTGG
CCCTAGCCCCTTCTACTGACTTCCTCATTTAAGCCAATTATATAAGCTCACATTGATCAGGGAGGGAGGGAAAGAGCTAAAGAGGGTCAC
ACAAGTGGCTATTTTCCCTGCAGTGTTTCTGTGTGGTGAAAATAACCCAGTCCACTAAGGGGCGGGAGTGAATGGATGGCTGGATTTTCC
CCAAGCTCCTTATAGCCTAATGTTGTCAGGATGTGAGTATGAGGAATTTAGCCTCTTATAGTGAAATGAGTCCAACTCTGGGCTTTGCTT
AGAGGAGAGCTCCTGTCAGGCTTCCTATAATATGAAAAGAAGTCACCATTGGGGAACTAGAGACCCCAGACCTTTTCATATGGATATTTG
AGAATGTAATGCATCTCAGGCCTCGTGCTGGAACTCTAGGGCACTCTAGGCAGGCTCAGAACACTTGATATTCCTGACAGCTACACACCT
GACATGCAGGTACATACCTGATCGGTGTCATCTCCTAACAAGGATTTTCAGTTCCTCGGGAGAGCAATAATCTTTGTAGGAAAGACATCC
CTGCAATAGGTGATATGTGGTCCTTAGAAGTTTTATTCCTTTACTACTTGGAAGAAAAGTTCTTTGGTGATTCTTCTCTGCTTTTGAAGA
TGATCAAAAGCATCTTCATTGATTTTCTGAAACGAAAGCCTTGTCTGAAACCAATTAATACTTGGGAAACAGCTGGGCTTGGAGGAGTAG
AATGCCAGAGATAAATCCATGGCTCCTGCTCTGGCTCTCTTCTGCAGAAATGAGGGCAACAGTGAGGCCACTTCCCTGGCAAATGTGCAG
CTCAGGATAGGGAAGCATAAGACCCTCTGTTTAAAAGAGAGTCAAGTAGGTAACCAAAGCCAAGCTCTGTGCAAGGTGCTTTGGAGTTGT
AAATTGAGGAGTGCATCCTTGCTGTCTTGAACCATTCTGTTTGCAATGGTGAGACCTTACATAACCTAGCCTTGCAGGGCCGCCACACAA
CCCTGGAGTCCTAGAGTTGGAGGAACCTTTGTATCCATCTGACTTCTCATTTTGCAGAATATGATGAGAAAGTAGAGGATCGCTCTGTTC
ACCACTCTTGCTATTCCATTAGTGGGGAGATGCCTGCTAGCATGTGTGAGGGGAACACTCTGATACACTGGGAAGTATCGGAAATTCCCA
GAAACACAAACATAAAATAACTCTCCTAGACCCAGGTACTGGGGACTGTCTCAGTCCGTGTGGCATGATAAATAAAAGGTTAGGATCAAG
TCTTTGTATTTTTCAAGATGTGGTAGCTGATTATTCCTGTTTTAAGTACTCTGAAATTGATCTGTGATCAATAATACTAATATGTTATCT
TTTACCGTATTCTGCCTCTCACTATTGATTTTAATTAGTTAGGAGTATTTGAGCTGTTATTTCTTGAGCTTAATATTTTTTTAGAGTTAA
CTCTTTAAGGAGATAATCATGGCTGTAGACAAGGCCAGGGCTGGCTGACGTGCCTTAGAAGGTTTGAATGCAATAAAGCGGTGTTTGGCG
TTCTCCTGCATTGTAGTGCGGGTACAAAATGCTATTTGTTCGTCATACTGTTGTCAGCAGATGAGCCGCCCACTACAGACGGCTACTGCC
CAGGGACCTGCCCAGGCCCCACCCAAGGGCTCCCAAGGGTTGAGATTTCTGCAGACCTATAGCCAGCACACTTAGTCCTGCCCTATATAG
AGTTCCTCTTCGGGAAGCTTTTGATAAGGAATTCTCAGACCGATAGGATGTCTGTCTGGGCTTTGCTGCGGGACAGTCTAACTGTGGGGG
CTAGGGGAAAGCAGGAGAGTATCGATCAAAGAGTAAGCCACACACGGATAATCAGTTACTAGGGATGGAGGTGTGAGGGTTCATTATATT
ATTCATTTTACTGTTGTATATGTTTGAAAATGTCTATAATAAAAAGCTTTAAAAAAAAAAAAGAAACAAAAATAGTTCAGGCCAGCAATG
GGCCCTCCATGTTCAGTGGATTTTATCCTTGTTTCAATTGGGGTAGGAGTTCCAGGAGGTGTGGATTGGAGGTTGTCTAAAGAATTGAAC
TGGCCTTTGTCCCTGCTTCCTGGGAGGGAGACTTTCAGTCCTTGACATTTCCAGGGTAATAGGAGTGTCTTTGTTATTTGTGAGGCCATG
GGATCACACCTGAGCTTATGCTAAAAGGTGGGATGACTCAGAGCTGGGGCTGGTCACCAGACAGACTGACCATGTGATTAGAGGTTTGAG
GCTTTGAGTCAGCCTGACCTATGGGGCGGGGGACTGGAGGCTGAGTTTAATCATCTGGCCAGTGCTTTAATCAGTACATCATGAAACCCT
AATAAAAACTCTGGACACTAAAGCTCAGCATAGCTTCCTGGGTGGTGAAGCTGTGGCTATGCCGGCAGGGCAGTGTGCCCTAATTCCACG
AAGAGGGGGCATGGGAGCACTGTGCTCAAGACCCTTCCAGACCTTTCCCTGTGTCTTCCTTGGCTTGTGGAGCTGATTTGTATCCTTTAT

>55336_55336_2_MSI2-TRIM25_MSI2_chr17_55339553_ENST00000322684_TRIM25_chr17_54985924_ENST00000316881_length(amino acids)=531AA_BP=100
MADLTSVLTSVMFSPSSKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPK
VAFPRRAQPKATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQLQQEYTEMKALLDASETTSTRKIKEEEKRVNSKFDTIYQ
ILLKKKSEIQTLKEEIEQSLTKRDEFEFLEKASKLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQEPTPSSGDPGEHD
PASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGLEAAAKATSSHPNSTSLKAKVLETFLAKSRPELLEYYIKV
ILDYNTAHNKVALSECYTVASVAEMPQNYRPHPQRFTYCSQVLGLHCYKKGIHYWEVELQKNNFCGVGICYGSMNRQGPESRLGRNSASW

--------------------------------------------------------------
>55336_55336_3_MSI2-TRIM25_MSI2_chr17_55339553_ENST00000416426_TRIM25_chr17_54985924_ENST00000316881_length(transcript)=5468nt_BP=381nt
AGAGCCAGAGAGAACTTCCAGCGCAAAAGGAAAATAAAACTTGTGGCTGGTGTTTGTGCAGGAGGGTCTCCGCCATCCTGAAGCCCCCCG
ATCCTGGGGCGTCTCGGGGGCCGCCAAAGGAGCGCCAGGGTTAAAATGTTTATCGGTGGACTGAGCTGGCAGACCTCACCAGATAGCCTT
AGAGACTATTTTAGCAAATTTGGAGAAATTAGAGAATGTATGGTCATGAGAGATCCCACTACGAAACGCTCCAGAGGCTTCGGTTTCGTC
ACGTTCGCAGACCCAGCAAGTGTAGATAAAGTATTAGGTCAGCCCCACCATGAGTTAGATTCCAAGACGATTGACCCCAAAGTTGCATTT
CCTCGTCGAGCGCAACCCAAGGCCACCCTGAGGCACAAACTAACTGTCATGTACAGTCAGATCAACGGGGCGTCGAGAGCACTGGATGAT
GTGAGAAACAGGCAGCAGGATGTGCGGATGACTGCAAACAGAAAGGTGGAGCAGCTACAACAAGAATACACGGAAATGAAGGCTCTCTTG
GACGCCTCAGAGACCACCTCGACAAGGAAGATAAAGGAAGAGGAGAAGAGGGTCAACAGCAAGTTTGACACCATTTATCAGATTCTCCTC
AAGAAGAAGAGTGAGATCCAGACCTTGAAGGAGGAGATTGAACAGAGCCTGACCAAGAGGGATGAGTTCGAGTTTCTGGAGAAAGCATCA
AAACTGCGAGGAATCTCAACAAAGCCAGTCTACATCCCCGAGGTGGAACTGAACCACAAGCTGATAAAAGGCATCCACCAGAGCACCATA
GACCTCAAAAACGAGCTGAAGCAGTGCATCGGGCGGCTCCAGGAGCCCACCCCCAGTTCAGGTGACCCTGGAGAGCATGACCCAGCGTCC
ACACACAAATCCACACGCCCTGTGAAGAAGGTCTCCAAAGAGGAAAAGAAATCCAAGAAACCTCCCCCTGTCCCTGCCTTACCCAGCAAG
CTTCCCACGTTTGGAGCCCCGGAACAGTTAGTGGATTTAAAACAAGCTGGCTTGGAGGCTGCAGCCAAAGCCACCAGCTCACATCCGAAC
TCAACATCTCTCAAGGCCAAGGTGCTGGAGACCTTCCTGGCCAAGTCCAGACCTGAGCTCCTGGAGTATTACATTAAAGTCATCCTGGAC
TACAACACCGCCCACAACAAAGTGGCTCTGTCAGAGTGCTATACAGTAGCTTCTGTGGCTGAGATGCCTCAGAACTACCGGCCGCATCCC
CAGAGGTTCACATACTGCTCTCAGGTGCTGGGCCTGCACTGCTACAAGAAGGGGATCCACTACTGGGAGGTGGAGCTGCAGAAGAACAAC
TTCTGTGGGGTAGGCATCTGCTACGGAAGCATGAACCGGCAGGGCCCAGAAAGCAGGCTCGGCCGCAACAGCGCCTCCTGGTGCGTGGAG
TGGTTCAACACCAAGATCTCTGCCTGGCACAATAACGTGGAGAAAACCCTGCCCTCCACCAAGGCCACGCGGGTGGGCGTGCTTCTCAAC
TGTGACCACGGCTTTGTCATCTTCTTCGCTGTTGCCGACAAGGTCCACCTGATGTATAAGTTCAGGGTGGACTTTACTGAGGCTTTGTAC
CCGGCTTTCTGGGTATTTTCTGCTGGTGCCACACTCTCCATCTGCTCCCCCAAGTAGGCAGGCTGTAGGCACTTGGGCTGACTGCCTGCA
GAAGTCCCAAGACCCTAGTGAAAATACAGCAGGCAGAACTCTCCTTGGATAATTCCCCAAGAGGTCCCAAGGATTGGGAGCATGGGAGGG
GAGCTGGCGGGAGGGTGGGAGGTGGGATTTAGCCAGGAAAGGGGTGAGAGTGATTGTGTTGTGGGCGAGGAGGCGTTTCCACCCCCTGGT
GCCTATCAGGGCAGGGTGACCTACTCCCCATTGTTCTGGAAATCTCCAGGCTGCTGGGCAGCTGGGCAGAGCTCTGGGAAGTGAAGTCAT
GAGTGCCCGATTCCTCTTAGAGAAAATCCATAGCTACTGTAGGTTCTGTCTTGGGCCACTTGGATCTGAAGGCTGCCCCTTTGCTCTCTG
GGGTAGCCTTCAGATCTTGGTGTTTTGAATTCTTACTATAGATGTTTTTAAAGTTCCAAAGTCATTGAGTTTCAATGTTACATAAACTCC
ATTACCCGCATGTTGGGGCTTGATCTCCTGGTTATTATCTGTGCTTGAGGAAACACCCACAGCAGTCTCTACCCAGAACAGTTTCCTAAA
GAGGCATACCCTCTTCCTCCACTGGAAAATAGTGCGTTCCCTTCCTACCCTGCACACCCATCGCCCCCACATTGATGGTTTTCAAACAGC
AAACTTTTCAGCTAAAGCTTCAAACCATGATTGGAATCAGCCTGTGTTGGATTTGTGATTCAGGGTCATGGTGACCCTGATCCAGTTTGG
GTGGAAATCCTTCCTAAGTATCATAAGAAGCATCTTGGCAGAGATGCTTTGGTGGCAGCCATGAGCTTTGCTGGAGGCCTTGCTTCCCAT
AGCCTTGGCTGTGGGGCAAGGAACTCTGCCAGGCGAGGGGGATGCTGCCCTGGATCAACAGAAGCCTGGTGGGTTTGCTCGTGTTAGAGT
GTCCTGCCTTCTTACTGACAACTCTTCTCGGTGATAGCCTCTCTTCCCTGGATTGTGACATATGGAATGACAGTGCAGGTACCACCGAGG
CTAGCACAGTCAAGCCTCCAGCTAAGCTGGATCCCTGAAGCCTGCTATCATGCAGACAGGCTATGCGGCTGCCTCGGACCATGCTAGGCC
ACTTGCTGGGGTGTCAACCTACCACCAAAGGGGTCTTTTAGCAAACCTCATGGGGAACAGGAACATTCCTGTTCATCCCTGGCCACAGGC
TGCAGACCCAGCACTGGCCCTTGCGTGAGTCAGAGCCTGGGGCTGGCCCTAGCCCCTTCTACTGACTTCCTCATTTAAGCCAATTATATA
AGCTCACATTGATCAGGGAGGGAGGGAAAGAGCTAAAGAGGGTCACACAAGTGGCTATTTTCCCTGCAGTGTTTCTGTGTGGTGAAAATA
ACCCAGTCCACTAAGGGGCGGGAGTGAATGGATGGCTGGATTTTCCCCAAGCTCCTTATAGCCTAATGTTGTCAGGATGTGAGTATGAGG
AATTTAGCCTCTTATAGTGAAATGAGTCCAACTCTGGGCTTTGCTTAGAGGAGAGCTCCTGTCAGGCTTCCTATAATATGAAAAGAAGTC
ACCATTGGGGAACTAGAGACCCCAGACCTTTTCATATGGATATTTGAGAATGTAATGCATCTCAGGCCTCGTGCTGGAACTCTAGGGCAC
TCTAGGCAGGCTCAGAACACTTGATATTCCTGACAGCTACACACCTGACATGCAGGTACATACCTGATCGGTGTCATCTCCTAACAAGGA
TTTTCAGTTCCTCGGGAGAGCAATAATCTTTGTAGGAAAGACATCCCTGCAATAGGTGATATGTGGTCCTTAGAAGTTTTATTCCTTTAC
TACTTGGAAGAAAAGTTCTTTGGTGATTCTTCTCTGCTTTTGAAGATGATCAAAAGCATCTTCATTGATTTTCTGAAACGAAAGCCTTGT
CTGAAACCAATTAATACTTGGGAAACAGCTGGGCTTGGAGGAGTAGAATGCCAGAGATAAATCCATGGCTCCTGCTCTGGCTCTCTTCTG
CAGAAATGAGGGCAACAGTGAGGCCACTTCCCTGGCAAATGTGCAGCTCAGGATAGGGAAGCATAAGACCCTCTGTTTAAAAGAGAGTCA
AGTAGGTAACCAAAGCCAAGCTCTGTGCAAGGTGCTTTGGAGTTGTAAATTGAGGAGTGCATCCTTGCTGTCTTGAACCATTCTGTTTGC
AATGGTGAGACCTTACATAACCTAGCCTTGCAGGGCCGCCACACAACCCTGGAGTCCTAGAGTTGGAGGAACCTTTGTATCCATCTGACT
TCTCATTTTGCAGAATATGATGAGAAAGTAGAGGATCGCTCTGTTCACCACTCTTGCTATTCCATTAGTGGGGAGATGCCTGCTAGCATG
TGTGAGGGGAACACTCTGATACACTGGGAAGTATCGGAAATTCCCAGAAACACAAACATAAAATAACTCTCCTAGACCCAGGTACTGGGG
ACTGTCTCAGTCCGTGTGGCATGATAAATAAAAGGTTAGGATCAAGTCTTTGTATTTTTCAAGATGTGGTAGCTGATTATTCCTGTTTTA
AGTACTCTGAAATTGATCTGTGATCAATAATACTAATATGTTATCTTTTACCGTATTCTGCCTCTCACTATTGATTTTAATTAGTTAGGA
GTATTTGAGCTGTTATTTCTTGAGCTTAATATTTTTTTAGAGTTAACTCTTTAAGGAGATAATCATGGCTGTAGACAAGGCCAGGGCTGG
CTGACGTGCCTTAGAAGGTTTGAATGCAATAAAGCGGTGTTTGGCGTTCTCCTGCATTGTAGTGCGGGTACAAAATGCTATTTGTTCGTC
ATACTGTTGTCAGCAGATGAGCCGCCCACTACAGACGGCTACTGCCCAGGGACCTGCCCAGGCCCCACCCAAGGGCTCCCAAGGGTTGAG
ATTTCTGCAGACCTATAGCCAGCACACTTAGTCCTGCCCTATATAGAGTTCCTCTTCGGGAAGCTTTTGATAAGGAATTCTCAGACCGAT
AGGATGTCTGTCTGGGCTTTGCTGCGGGACAGTCTAACTGTGGGGGCTAGGGGAAAGCAGGAGAGTATCGATCAAAGAGTAAGCCACACA
CGGATAATCAGTTACTAGGGATGGAGGTGTGAGGGTTCATTATATTATTCATTTTACTGTTGTATATGTTTGAAAATGTCTATAATAAAA
AGCTTTAAAAAAAAAAAAGAAACAAAAATAGTTCAGGCCAGCAATGGGCCCTCCATGTTCAGTGGATTTTATCCTTGTTTCAATTGGGGT
AGGAGTTCCAGGAGGTGTGGATTGGAGGTTGTCTAAAGAATTGAACTGGCCTTTGTCCCTGCTTCCTGGGAGGGAGACTTTCAGTCCTTG
ACATTTCCAGGGTAATAGGAGTGTCTTTGTTATTTGTGAGGCCATGGGATCACACCTGAGCTTATGCTAAAAGGTGGGATGACTCAGAGC
TGGGGCTGGTCACCAGACAGACTGACCATGTGATTAGAGGTTTGAGGCTTTGAGTCAGCCTGACCTATGGGGCGGGGGACTGGAGGCTGA
GTTTAATCATCTGGCCAGTGCTTTAATCAGTACATCATGAAACCCTAATAAAAACTCTGGACACTAAAGCTCAGCATAGCTTCCTGGGTG
GTGAAGCTGTGGCTATGCCGGCAGGGCAGTGTGCCCTAATTCCACGAAGAGGGGGCATGGGAGCACTGTGCTCAAGACCCTTCCAGACCT

>55336_55336_3_MSI2-TRIM25_MSI2_chr17_55339553_ENST00000416426_TRIM25_chr17_54985924_ENST00000316881_length(amino acids)=527AA_BP=96
MGRLGGRQRSARVKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFP
RRAQPKATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQLQQEYTEMKALLDASETTSTRKIKEEEKRVNSKFDTIYQILLK
KKSEIQTLKEEIEQSLTKRDEFEFLEKASKLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQEPTPSSGDPGEHDPAST
HKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGLEAAAKATSSHPNSTSLKAKVLETFLAKSRPELLEYYIKVILDY
NTAHNKVALSECYTVASVAEMPQNYRPHPQRFTYCSQVLGLHCYKKGIHYWEVELQKNNFCGVGICYGSMNRQGPESRLGRNSASWCVEW

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MSI2-TRIM25


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneTRIM25chr17:55339553chr17:54985924ENST0000031688109180_450199.0631.0influenza A virus NS1
TgeneTRIM25chr17:55339553chr17:54985924ENST00000537230010180_450199.0684.3333333333334influenza A virus NS1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MSI2-TRIM25


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MSI2-TRIM25


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource