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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MSL2-CEP70 (FusionGDB2 ID:55353)

Fusion Gene Summary for MSL2-CEP70

check button Fusion gene summary
Fusion gene informationFusion gene name: MSL2-CEP70
Fusion gene ID: 55353
HgeneTgene
Gene symbol

MSL2

CEP70

Gene ID

55167

80321

Gene nameMSL complex subunit 2centrosomal protein 70
SynonymsMSL-2|MSL2L1|RNF184BITE
Cytomap

3q22.3

3q22.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase MSL2E3 ubiquitin-protein transferase MSL2MSL2-like 1male-specific lethal 2 homologmale-specific lethal 2-like 1male-specific lethal-2 homolog 1ring finger protein 184centrosomal protein of 70 kDacentrosomal protein 70kDap10-binding proteintesticular tissue protein Li 36
Modification date2020031320200327
UniProtAcc

Q9HCI7

Q8NHQ1

Ensembl transtripts involved in fusion geneENST00000309993, ENST00000434835, 
ENST00000464035, ENST00000478673, 
ENST00000264982, ENST00000481834, 
ENST00000484888, ENST00000489254, 
ENST00000542237, 
Fusion gene scores* DoF score10 X 6 X 9=5406 X 6 X 5=180
# samples 147
** MAII scorelog2(14/540*10)=-1.94753258010586
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MSL2 [Title/Abstract] AND CEP70 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMSL2(135913814)-CEP70(138256189), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMSL2

GO:0043984

histone H4-K16 acetylation

20018852


check buttonFusion gene breakpoints across MSL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CEP70 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-EP-A2KA-01AMSL2chr3

135913814

-CEP70chr3

138256189

-


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Fusion Gene ORF analysis for MSL2-CEP70

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000309993ENST00000464035MSL2chr3

135913814

-CEP70chr3

138256189

-
5CDS-5UTRENST00000309993ENST00000478673MSL2chr3

135913814

-CEP70chr3

138256189

-
In-frameENST00000309993ENST00000264982MSL2chr3

135913814

-CEP70chr3

138256189

-
In-frameENST00000309993ENST00000481834MSL2chr3

135913814

-CEP70chr3

138256189

-
In-frameENST00000309993ENST00000484888MSL2chr3

135913814

-CEP70chr3

138256189

-
In-frameENST00000309993ENST00000489254MSL2chr3

135913814

-CEP70chr3

138256189

-
In-frameENST00000309993ENST00000542237MSL2chr3

135913814

-CEP70chr3

138256189

-
intron-3CDSENST00000434835ENST00000264982MSL2chr3

135913814

-CEP70chr3

138256189

-
intron-3CDSENST00000434835ENST00000481834MSL2chr3

135913814

-CEP70chr3

138256189

-
intron-3CDSENST00000434835ENST00000484888MSL2chr3

135913814

-CEP70chr3

138256189

-
intron-3CDSENST00000434835ENST00000489254MSL2chr3

135913814

-CEP70chr3

138256189

-
intron-3CDSENST00000434835ENST00000542237MSL2chr3

135913814

-CEP70chr3

138256189

-
intron-5UTRENST00000434835ENST00000464035MSL2chr3

135913814

-CEP70chr3

138256189

-
intron-5UTRENST00000434835ENST00000478673MSL2chr3

135913814

-CEP70chr3

138256189

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000309993MSL2chr3135913814-ENST00000264982CEP70chr3138256189-28758758182203461
ENST00000309993MSL2chr3135913814-ENST00000542237CEP70chr3138256189-26848758182203461
ENST00000309993MSL2chr3135913814-ENST00000489254CEP70chr3138256189-24618758182203461
ENST00000309993MSL2chr3135913814-ENST00000484888CEP70chr3138256189-22168758182203461
ENST00000309993MSL2chr3135913814-ENST00000481834CEP70chr3138256189-22888758182074418

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000309993ENST00000264982MSL2chr3135913814-CEP70chr3138256189-0.0003572520.9996427
ENST00000309993ENST00000542237MSL2chr3135913814-CEP70chr3138256189-0.0004115560.99958843
ENST00000309993ENST00000489254MSL2chr3135913814-CEP70chr3138256189-0.0003964690.99960357
ENST00000309993ENST00000484888MSL2chr3135913814-CEP70chr3138256189-0.0005920010.999408
ENST00000309993ENST00000481834MSL2chr3135913814-CEP70chr3138256189-0.0007482650.99925166

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Fusion Genomic Features for MSL2-CEP70


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MSL2-CEP70


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:135913814/chr3:138256189)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MSL2

Q9HCI7

CEP70

Q8NHQ1

FUNCTION: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. {ECO:0000269|PubMed:21726816}.FUNCTION: Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCEP70chr3:135913814chr3:138256189ENST00000264982518254_326155598.0Coiled coilOntology_term=ECO:0000255
TgeneCEP70chr3:135913814chr3:138256189ENST0000046403546254_326155213.0Coiled coilOntology_term=ECO:0000255
TgeneCEP70chr3:135913814chr3:138256189ENST00000481834516254_326155555.0Coiled coilOntology_term=ECO:0000255
TgeneCEP70chr3:135913814chr3:138256189ENST00000484888518254_326155598.0Coiled coilOntology_term=ECO:0000255
TgeneCEP70chr3:135913814chr3:138256189ENST00000542237417254_326135578.0Coiled coilOntology_term=ECO:0000255
TgeneCEP70chr3:135913814chr3:138256189ENST00000264982518483_516155598.0RepeatNote=TPR
TgeneCEP70chr3:135913814chr3:138256189ENST0000046403546483_516155213.0RepeatNote=TPR
TgeneCEP70chr3:135913814chr3:138256189ENST00000481834516483_516155555.0RepeatNote=TPR
TgeneCEP70chr3:135913814chr3:138256189ENST00000484888518483_516155598.0RepeatNote=TPR
TgeneCEP70chr3:135913814chr3:138256189ENST00000542237417483_516135578.0RepeatNote=TPR

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMSL2chr3:135913814chr3:138256189ENST00000309993-12396_46347578.0Compositional biasNote=Lys-rich
HgeneMSL2chr3:135913814chr3:138256189ENST00000434835-12396_4630504.0Compositional biasNote=Lys-rich
HgeneMSL2chr3:135913814chr3:138256189ENST00000309993-1244_8547578.0Zinc fingerRING-type
HgeneMSL2chr3:135913814chr3:138256189ENST00000434835-1244_850504.0Zinc fingerRING-type
TgeneCEP70chr3:135913814chr3:138256189ENST0000026498251875_179155598.0Coiled coilOntology_term=ECO:0000255
TgeneCEP70chr3:135913814chr3:138256189ENST000004640354675_179155213.0Coiled coilOntology_term=ECO:0000255
TgeneCEP70chr3:135913814chr3:138256189ENST0000048183451675_179155555.0Coiled coilOntology_term=ECO:0000255
TgeneCEP70chr3:135913814chr3:138256189ENST0000048488851875_179155598.0Coiled coilOntology_term=ECO:0000255
TgeneCEP70chr3:135913814chr3:138256189ENST0000054223741775_179135578.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for MSL2-CEP70


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>55353_55353_1_MSL2-CEP70_MSL2_chr3_135913814_ENST00000309993_CEP70_chr3_138256189_ENST00000264982_length(transcript)=2875nt_BP=875nt
GCACTTCCTCCCCGGCCTTCCCCTCCGGGTTGAGGACTCCCGCCCGCCTCGCCACCTCGGGGAACTGCGGGCTGCAACCCACGGGGCGGA
GAGCCAGGGCGCAGTCTGGGCCCCGCGTCCGATATGGAGAGCGCGGCGGCGGCGTCCGCCAGCCGCAACATCAACCTTCGTCGCCGCCGC
GGCGTCTTGCACTAGATCCGGGAAGCCGCTGCCCGACCGTCGTCCTTGCCGTCGCCGCCGCCTCCGCGCCCTGTACTGGGATGGAGTAAG
AGGCCCTGCAGCCCGGGAGAAGCGTGCCGCGCCTCAGACGGGGCCGGGGCCTGCTCCCGCGCCTGCCAGCTCGACTTGAGGAGGCGCCTC
CGTGTCCGGAGATGGAGCTCGAGTGCAGGCCGCCTGCCGAGCCGCGGGGCTAGACTGAGCTCCGAGTCCCGCCCCGAGCGCCCAAGCCGC
CGCGTTCTGCGCTCTGTGGTCGCTCCGGACGAACTCGAACGCTGGTTTCTCTCTCATATTTTTGGTCTGGAAGTCTCAGGGACGGAGGGG
CGCCAAGGCCCCATGTGTGGGAGGATTGTTTCAGCTCCACAAACTTGCACGGATTTTGGTTACTTGTTTGGCCAATGGTTCGGCTCTGAT
TTCTTCCGAATTGTTGCAAATTCGCCATCGTTCCCTGGCTGCTTACTAAGTTGGATCCGGAATTTCTTTTCAACCGGGAGCCATTGGTGT
CGAAGTGTCTGCAATGAACCCCGTGAATGCTACTGCTCTCTACATTTCCGCGAGCCGCCTAGTGCTCAACTACGACCCCGGAGACCCCAA
GGCGTTTACTGAGATTAACAGGCTCTTGCCTTACTTCCGACAGTCCCTTTCGTGCTGTGTTTGCGGTGAAGTGCCAGCATTATAAGAAAA
AACGAACGGAGCAAGAAGAAACTATTGCTTCTTTGCAAATGGAAGTCTGTAGATTAAAAAAGGAGGAAGAAGATCGCATTGTCACTCAAA
ACAGAGTGTTTGCCTATCTGTGCAAAAGAGTTCCTCATACCGTCTTGGATAGACAGTTGCTTTGTCTAATTGATTACTATGAATCTAAAA
TTAGAAAAATTCATACACAAAGGCAATATAAAGAAGATGAAAGTCAGTCAGAAGAAGAAAACGACTACAGAAATCTGGATGCCTCACCAA
CTTATAAAGGCCTTTTAATGTCATTACAGAATCAACTCAAGGAATCAAAATCTAAGATTGATGCACTTTCAAGTGAAAAGCTGAACCTCC
AAAAAGATTTGGAAACCAGGCCTACGCAGCATGAATTAAGACTTTATAAACAGCAGGTGAAGAAGCTGGAAAAAGCCCTTAAGAAAAACG
TCAAATTACAGGAGCTTATTAATCATAAGAAGGCTGAGGACACAGAGAAGAAAGATGAGCCCAGCAAATATAATCAGCAACAGGCCCTAA
TTGACCAGAGATACTTTCAGGTGCTGTGTAGCATCAATTCAATTATCCACAATCCAAGAGCTCCAGTAATAATTTATAAACAGACCAAAG
GGGGAGTCCAAAATTTTAATAAAGATCTTGTTCAAGATTGTGGATTTGAGCATCTTGTTCCTGTAATAGAAATGTGGGCAGATCAACTGA
CATCCTTAAAGGATTTGTATAAGTCCTTGAAAACACTATCTGCAGAACTGGTACCTTGGCTTAATTTGAAGAAGCAGGATGAAAATGAAG
GTATCAAAGTTGAAGATTTGTTGTTTATAGTAGATACTATGCTGGAAGAAGTTGAAAATAAGGAAAAGGACAGCAATATGCCACACTTTC
AAACTTTGCAAGCTATTGTTTCTCACTTCCAAAAGTTATTTGATGTGCCTTCTTTAAATGGAGTCTATCCCCGAATGAATGAAGTTTATA
CTAGGCTTGGAGAAATGAACAATGCTGTGAGAAACCTCCAAGAACTCTTAGAATTAGATAGTTCATCCTCATTGTGTGTGCTAGTAAGCA
CTGTTGGAAAACTCTGTAGGCTGATTAATGAAGATGTGAATGAGCAGGTTATGCAGGTATTAGGACCTGAAGACCTCCAGAGCATTATCT
ACAAATTGGAAGAACACGAGGAATTTTTCCCAGCATTTCAGGCATTTACTAATGATCTACTTGAAATCTTAGAAATTGATGACTTGGATG
CCATTGTACCTGCAGTAAAGAAATTAAAAGTACTTTCATACTGAAAACAAATCAAATCATTTTTACTGTGTAAATTGTATTCTTAACATT
TTGTATTTTGTAGGATTGATCTTATTTTGAGACAAGGGTTGTAAAATGTATTTGCTCTCAGAATTCATCCCCTTCTTAGTATTAGGTCAT
TCTTCATCTGTATAATTTTTATTAACTTTGAGATTCTTATACAGAAAATAGTTGCAAGGGTAAGGTAATTAACTTTAGATCCCTTCATTT
CTAAAGCAATTATTGAGTGCTTAAAATTTAAGGTTGTTTTAGAGTGGAGTTTGTGAGTAAAAGAGGAGCCCAGGGAGACAGATTGCAAGT
AGTAGGTTGCAATCTTTTAGATTCAGCTTGTAATAATCTTTGAGCCACACCAAAAGGAATGCCAAGGGCTCTCTAAATTTAGCCAGTAGG
AAGCTACTGCTCTCCTGGCAAGGATTAATTGGCACATTCTGTTAAGATATCCCTCATGACAGTTGCCCTTTCAAAGCAGGAGGAAGAAAA
GGAAGAAAGAAAAACTGTTTCATCATTTCTGTTAGGGTAGGAAATGAATCATAGGGTAAAATGGATGAGTAGATAGAAGTCTCTCATTTA

>55353_55353_1_MSL2-CEP70_MSL2_chr3_135913814_ENST00000309993_CEP70_chr3_138256189_ENST00000264982_length(amino acids)=461AA_BP=19
MRLTGSCLTSDSPFRAVFAVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRK
IHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKL
QELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIHNPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSL
KDLYKSLKTLSAELVPWLNLKKQDENEGIKVEDLLFIVDTMLEEVENKEKDSNMPHFQTLQAIVSHFQKLFDVPSLNGVYPRMNEVYTRL
GEMNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEQVMQVLGPEDLQSIIYKLEEHEEFFPAFQAFTNDLLEILEIDDLDAIV

--------------------------------------------------------------
>55353_55353_2_MSL2-CEP70_MSL2_chr3_135913814_ENST00000309993_CEP70_chr3_138256189_ENST00000481834_length(transcript)=2288nt_BP=875nt
GCACTTCCTCCCCGGCCTTCCCCTCCGGGTTGAGGACTCCCGCCCGCCTCGCCACCTCGGGGAACTGCGGGCTGCAACCCACGGGGCGGA
GAGCCAGGGCGCAGTCTGGGCCCCGCGTCCGATATGGAGAGCGCGGCGGCGGCGTCCGCCAGCCGCAACATCAACCTTCGTCGCCGCCGC
GGCGTCTTGCACTAGATCCGGGAAGCCGCTGCCCGACCGTCGTCCTTGCCGTCGCCGCCGCCTCCGCGCCCTGTACTGGGATGGAGTAAG
AGGCCCTGCAGCCCGGGAGAAGCGTGCCGCGCCTCAGACGGGGCCGGGGCCTGCTCCCGCGCCTGCCAGCTCGACTTGAGGAGGCGCCTC
CGTGTCCGGAGATGGAGCTCGAGTGCAGGCCGCCTGCCGAGCCGCGGGGCTAGACTGAGCTCCGAGTCCCGCCCCGAGCGCCCAAGCCGC
CGCGTTCTGCGCTCTGTGGTCGCTCCGGACGAACTCGAACGCTGGTTTCTCTCTCATATTTTTGGTCTGGAAGTCTCAGGGACGGAGGGG
CGCCAAGGCCCCATGTGTGGGAGGATTGTTTCAGCTCCACAAACTTGCACGGATTTTGGTTACTTGTTTGGCCAATGGTTCGGCTCTGAT
TTCTTCCGAATTGTTGCAAATTCGCCATCGTTCCCTGGCTGCTTACTAAGTTGGATCCGGAATTTCTTTTCAACCGGGAGCCATTGGTGT
CGAAGTGTCTGCAATGAACCCCGTGAATGCTACTGCTCTCTACATTTCCGCGAGCCGCCTAGTGCTCAACTACGACCCCGGAGACCCCAA
GGCGTTTACTGAGATTAACAGGCTCTTGCCTTACTTCCGACAGTCCCTTTCGTGCTGTGTTTGCGGTGAAGTGCCAGCATTATAAGAAAA
AACGAACGGAGCAAGAAGAAACTATTGCTTCTTTGCAAATGGAAGTCTGTAGATTAAAAAAGGAGGAAGAAGATCGCATTGTCACTCAAA
ACAGAGTGTTTGCCTATCTGTGCAAAAGAGTTCCTCATACCGTCTTGGATAGACAGTTGCTTTGTCTAATTGATTACTATGAATCTAAAA
TTAGAAAAATTCATACACAAAGGCAATATAAAGAAGATGAAAGTCAGTCAGAAGAAGAAAACGACTACAGAAATCTGGATGCCTCACCAA
CTTATAAAGGCCTTTTAATGTCATTACAGAATCAACTCAAGGAATCAAAATCTAAGATTGATGCACTTTCAAGTGAAAAGCTGAACCTCC
AAAAAGATTTGGAAACCAGGCCTACGCAGCATGAATTAAGACTTTATAAACAGCAGGTGAAGAAGCTGGAAAAAGCCCTTAAGAAAAACG
TCAAATTACAGGAGCTTATTAATCATAAGAAGGCTGAGGACACAGAGAAGAAAGATGAGCCCAGCAAATATAATCAGCAACAGGCCCTAA
TTGACCAGAGATACTTTCAGGTGCTGTGTAGCATCAATTCAATTATCCACAATCCAAGAGCTCCAGTAATAATTTATAAACAGACCAAAG
GGGGAGTCCAAAATTTTAATAAAGATCTTGTTCAAGATTGTGGATTTGAGCATCTTGTTCCTGTAATAGAAATGTGGGCAGATCAACTGA
CATCCTTAAAGGATTTGTATAAGTCCTTGAAAACACTATCTGCAGAACTGGTACCTTGGCTTAATTTGAAGAAGCAGGATGAAAATGAAG
GTATCAAAGTTGAAGATTTGTTGTTTATAGTAGATACTATGCTGGAAGAAGTTGAAAATAAGGAAAAGGACAGCAATATGCCACACTTTC
AAACTTTGCAAGCTATTGTTTCTCACTTCCAAAAGTTATTTGATGTGCCTTCTTTAAATGGAGTCTATCCCCGAATGAATGAAGTTTATA
CTAGGCTTGGAGAAATGAACAATGCTGTGAGAAACCTCCAAGAACTCTTAGAATTAGATAGTTCATCCTCATTGTGTGTGCTAGTAAGCA
CTGTTGGAAAACTCTGTAGGCTGATTAATGAAGATGTGAATGAGCAGGTTATGCAGGTATTAGGACCTGAAGACCTCCAGAGGTATTTGT
TTTAAAAGTTTACAAAGTATCATCCAGAATGGCTGGGTGTGGTGGCACACGCCTGTAGTCCCAGCTACTTGGGAGGCTGATGTGGGAGGA
TCACTTGAACCCAGGAGTTTAAGTCCAGTCTGAGCAAGGCAGTGAGACCCTGTCTCTAAACAATAAAAATTAAAATAAGTATTATCGAGA

>55353_55353_2_MSL2-CEP70_MSL2_chr3_135913814_ENST00000309993_CEP70_chr3_138256189_ENST00000481834_length(amino acids)=418AA_BP=19
MRLTGSCLTSDSPFRAVFAVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRK
IHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKL
QELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIHNPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSL
KDLYKSLKTLSAELVPWLNLKKQDENEGIKVEDLLFIVDTMLEEVENKEKDSNMPHFQTLQAIVSHFQKLFDVPSLNGVYPRMNEVYTRL

--------------------------------------------------------------
>55353_55353_3_MSL2-CEP70_MSL2_chr3_135913814_ENST00000309993_CEP70_chr3_138256189_ENST00000484888_length(transcript)=2216nt_BP=875nt
GCACTTCCTCCCCGGCCTTCCCCTCCGGGTTGAGGACTCCCGCCCGCCTCGCCACCTCGGGGAACTGCGGGCTGCAACCCACGGGGCGGA
GAGCCAGGGCGCAGTCTGGGCCCCGCGTCCGATATGGAGAGCGCGGCGGCGGCGTCCGCCAGCCGCAACATCAACCTTCGTCGCCGCCGC
GGCGTCTTGCACTAGATCCGGGAAGCCGCTGCCCGACCGTCGTCCTTGCCGTCGCCGCCGCCTCCGCGCCCTGTACTGGGATGGAGTAAG
AGGCCCTGCAGCCCGGGAGAAGCGTGCCGCGCCTCAGACGGGGCCGGGGCCTGCTCCCGCGCCTGCCAGCTCGACTTGAGGAGGCGCCTC
CGTGTCCGGAGATGGAGCTCGAGTGCAGGCCGCCTGCCGAGCCGCGGGGCTAGACTGAGCTCCGAGTCCCGCCCCGAGCGCCCAAGCCGC
CGCGTTCTGCGCTCTGTGGTCGCTCCGGACGAACTCGAACGCTGGTTTCTCTCTCATATTTTTGGTCTGGAAGTCTCAGGGACGGAGGGG
CGCCAAGGCCCCATGTGTGGGAGGATTGTTTCAGCTCCACAAACTTGCACGGATTTTGGTTACTTGTTTGGCCAATGGTTCGGCTCTGAT
TTCTTCCGAATTGTTGCAAATTCGCCATCGTTCCCTGGCTGCTTACTAAGTTGGATCCGGAATTTCTTTTCAACCGGGAGCCATTGGTGT
CGAAGTGTCTGCAATGAACCCCGTGAATGCTACTGCTCTCTACATTTCCGCGAGCCGCCTAGTGCTCAACTACGACCCCGGAGACCCCAA
GGCGTTTACTGAGATTAACAGGCTCTTGCCTTACTTCCGACAGTCCCTTTCGTGCTGTGTTTGCGGTGAAGTGCCAGCATTATAAGAAAA
AACGAACGGAGCAAGAAGAAACTATTGCTTCTTTGCAAATGGAAGTCTGTAGATTAAAAAAGGAGGAAGAAGATCGCATTGTCACTCAAA
ACAGAGTGTTTGCCTATCTGTGCAAAAGAGTTCCTCATACCGTCTTGGATAGACAGTTGCTTTGTCTAATTGATTACTATGAATCTAAAA
TTAGAAAAATTCATACACAAAGGCAATATAAAGAAGATGAAAGTCAGTCAGAAGAAGAAAACGACTACAGAAATCTGGATGCCTCACCAA
CTTATAAAGGCCTTTTAATGTCATTACAGAATCAACTCAAGGAATCAAAATCTAAGATTGATGCACTTTCAAGTGAAAAGCTGAACCTCC
AAAAAGATTTGGAAACCAGGCCTACGCAGCATGAATTAAGACTTTATAAACAGCAGGTGAAGAAGCTGGAAAAAGCCCTTAAGAAAAACG
TCAAATTACAGGAGCTTATTAATCATAAGAAGGCTGAGGACACAGAGAAGAAAGATGAGCCCAGCAAATATAATCAGCAACAGGCCCTAA
TTGACCAGAGATACTTTCAGGTGCTGTGTAGCATCAATTCAATTATCCACAATCCAAGAGCTCCAGTAATAATTTATAAACAGACCAAAG
GGGGAGTCCAAAATTTTAATAAAGATCTTGTTCAAGATTGTGGATTTGAGCATCTTGTTCCTGTAATAGAAATGTGGGCAGATCAACTGA
CATCCTTAAAGGATTTGTATAAGTCCTTGAAAACACTATCTGCAGAACTGGTACCTTGGCTTAATTTGAAGAAGCAGGATGAAAATGAAG
GTATCAAAGTTGAAGATTTGTTGTTTATAGTAGATACTATGCTGGAAGAAGTTGAAAATAAGGAAAAGGACAGCAATATGCCACACTTTC
AAACTTTGCAAGCTATTGTTTCTCACTTCCAAAAGTTATTTGATGTGCCTTCTTTAAATGGAGTCTATCCCCGAATGAATGAAGTTTATA
CTAGGCTTGGAGAAATGAACAATGCTGTGAGAAACCTCCAAGAACTCTTAGAATTAGATAGTTCATCCTCATTGTGTGTGCTAGTAAGCA
CTGTTGGAAAACTCTGTAGGCTGATTAATGAAGATGTGAATGAGCAGGTTATGCAGGTATTAGGACCTGAAGACCTCCAGAGCATTATCT
ACAAATTGGAAGAACACGAGGAATTTTTCCCAGCATTTCAGGCATTTACTAATGATCTACTTGAAATCTTAGAAATTGATGACTTGGATG

>55353_55353_3_MSL2-CEP70_MSL2_chr3_135913814_ENST00000309993_CEP70_chr3_138256189_ENST00000484888_length(amino acids)=461AA_BP=19
MRLTGSCLTSDSPFRAVFAVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRK
IHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKL
QELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIHNPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSL
KDLYKSLKTLSAELVPWLNLKKQDENEGIKVEDLLFIVDTMLEEVENKEKDSNMPHFQTLQAIVSHFQKLFDVPSLNGVYPRMNEVYTRL
GEMNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEQVMQVLGPEDLQSIIYKLEEHEEFFPAFQAFTNDLLEILEIDDLDAIV

--------------------------------------------------------------
>55353_55353_4_MSL2-CEP70_MSL2_chr3_135913814_ENST00000309993_CEP70_chr3_138256189_ENST00000489254_length(transcript)=2461nt_BP=875nt
GCACTTCCTCCCCGGCCTTCCCCTCCGGGTTGAGGACTCCCGCCCGCCTCGCCACCTCGGGGAACTGCGGGCTGCAACCCACGGGGCGGA
GAGCCAGGGCGCAGTCTGGGCCCCGCGTCCGATATGGAGAGCGCGGCGGCGGCGTCCGCCAGCCGCAACATCAACCTTCGTCGCCGCCGC
GGCGTCTTGCACTAGATCCGGGAAGCCGCTGCCCGACCGTCGTCCTTGCCGTCGCCGCCGCCTCCGCGCCCTGTACTGGGATGGAGTAAG
AGGCCCTGCAGCCCGGGAGAAGCGTGCCGCGCCTCAGACGGGGCCGGGGCCTGCTCCCGCGCCTGCCAGCTCGACTTGAGGAGGCGCCTC
CGTGTCCGGAGATGGAGCTCGAGTGCAGGCCGCCTGCCGAGCCGCGGGGCTAGACTGAGCTCCGAGTCCCGCCCCGAGCGCCCAAGCCGC
CGCGTTCTGCGCTCTGTGGTCGCTCCGGACGAACTCGAACGCTGGTTTCTCTCTCATATTTTTGGTCTGGAAGTCTCAGGGACGGAGGGG
CGCCAAGGCCCCATGTGTGGGAGGATTGTTTCAGCTCCACAAACTTGCACGGATTTTGGTTACTTGTTTGGCCAATGGTTCGGCTCTGAT
TTCTTCCGAATTGTTGCAAATTCGCCATCGTTCCCTGGCTGCTTACTAAGTTGGATCCGGAATTTCTTTTCAACCGGGAGCCATTGGTGT
CGAAGTGTCTGCAATGAACCCCGTGAATGCTACTGCTCTCTACATTTCCGCGAGCCGCCTAGTGCTCAACTACGACCCCGGAGACCCCAA
GGCGTTTACTGAGATTAACAGGCTCTTGCCTTACTTCCGACAGTCCCTTTCGTGCTGTGTTTGCGGTGAAGTGCCAGCATTATAAGAAAA
AACGAACGGAGCAAGAAGAAACTATTGCTTCTTTGCAAATGGAAGTCTGTAGATTAAAAAAGGAGGAAGAAGATCGCATTGTCACTCAAA
ACAGAGTGTTTGCCTATCTGTGCAAAAGAGTTCCTCATACCGTCTTGGATAGACAGTTGCTTTGTCTAATTGATTACTATGAATCTAAAA
TTAGAAAAATTCATACACAAAGGCAATATAAAGAAGATGAAAGTCAGTCAGAAGAAGAAAACGACTACAGAAATCTGGATGCCTCACCAA
CTTATAAAGGCCTTTTAATGTCATTACAGAATCAACTCAAGGAATCAAAATCTAAGATTGATGCACTTTCAAGTGAAAAGCTGAACCTCC
AAAAAGATTTGGAAACCAGGCCTACGCAGCATGAATTAAGACTTTATAAACAGCAGGTGAAGAAGCTGGAAAAAGCCCTTAAGAAAAACG
TCAAATTACAGGAGCTTATTAATCATAAGAAGGCTGAGGACACAGAGAAGAAAGATGAGCCCAGCAAATATAATCAGCAACAGGCCCTAA
TTGACCAGAGATACTTTCAGGTGCTGTGTAGCATCAATTCAATTATCCACAATCCAAGAGCTCCAGTAATAATTTATAAACAGACCAAAG
GGGGAGTCCAAAATTTTAATAAAGATCTTGTTCAAGATTGTGGATTTGAGCATCTTGTTCCTGTAATAGAAATGTGGGCAGATCAACTGA
CATCCTTAAAGGATTTGTATAAGTCCTTGAAAACACTATCTGCAGAACTGGTACCTTGGCTTAATTTGAAGAAGCAGGATGAAAATGAAG
GTATCAAAGTTGAAGATTTGTTGTTTATAGTAGATACTATGCTGGAAGAAGTTGAAAATAAGGAAAAGGACAGCAATATGCCACACTTTC
AAACTTTGCAAGCTATTGTTTCTCACTTCCAAAAGTTATTTGATGTGCCTTCTTTAAATGGAGTCTATCCCCGAATGAATGAAGTTTATA
CTAGGCTTGGAGAAATGAACAATGCTGTGAGAAACCTCCAAGAACTCTTAGAATTAGATAGTTCATCCTCATTGTGTGTGCTAGTAAGCA
CTGTTGGAAAACTCTGTAGGCTGATTAATGAAGATGTGAATGAGCAGGTTATGCAGGTATTAGGACCTGAAGACCTCCAGAGCATTATCT
ACAAATTGGAAGAACACGAGGAATTTTTCCCAGCATTTCAGGCATTTACTAATGATCTACTTGAAATCTTAGAAATTGATGACTTGGATG
CCATTGTACCTGCAGTAAAGAAATTAAAAGTACTTTCATACTGAAAACAAATCAAATCATTTTTACTGTGTAAATTGTATTCTTAACATT
TTGTATTTTGTAGGATTGATCTTATTTTGAGACAAGGGTTGTAAAATGTATTTGCTCTCAGAATTCATCCCCTTCTTAGTATTAGGTCAT
TCTTCATCTGTATAATTTTTATTAACTTTGAGATTCTTATACAGAAAATAGTTGCAAGGGTAAGGTAATTAACTTTAGATCCCTTCATTT

>55353_55353_4_MSL2-CEP70_MSL2_chr3_135913814_ENST00000309993_CEP70_chr3_138256189_ENST00000489254_length(amino acids)=461AA_BP=19
MRLTGSCLTSDSPFRAVFAVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRK
IHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKL
QELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIHNPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSL
KDLYKSLKTLSAELVPWLNLKKQDENEGIKVEDLLFIVDTMLEEVENKEKDSNMPHFQTLQAIVSHFQKLFDVPSLNGVYPRMNEVYTRL
GEMNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEQVMQVLGPEDLQSIIYKLEEHEEFFPAFQAFTNDLLEILEIDDLDAIV

--------------------------------------------------------------
>55353_55353_5_MSL2-CEP70_MSL2_chr3_135913814_ENST00000309993_CEP70_chr3_138256189_ENST00000542237_length(transcript)=2684nt_BP=875nt
GCACTTCCTCCCCGGCCTTCCCCTCCGGGTTGAGGACTCCCGCCCGCCTCGCCACCTCGGGGAACTGCGGGCTGCAACCCACGGGGCGGA
GAGCCAGGGCGCAGTCTGGGCCCCGCGTCCGATATGGAGAGCGCGGCGGCGGCGTCCGCCAGCCGCAACATCAACCTTCGTCGCCGCCGC
GGCGTCTTGCACTAGATCCGGGAAGCCGCTGCCCGACCGTCGTCCTTGCCGTCGCCGCCGCCTCCGCGCCCTGTACTGGGATGGAGTAAG
AGGCCCTGCAGCCCGGGAGAAGCGTGCCGCGCCTCAGACGGGGCCGGGGCCTGCTCCCGCGCCTGCCAGCTCGACTTGAGGAGGCGCCTC
CGTGTCCGGAGATGGAGCTCGAGTGCAGGCCGCCTGCCGAGCCGCGGGGCTAGACTGAGCTCCGAGTCCCGCCCCGAGCGCCCAAGCCGC
CGCGTTCTGCGCTCTGTGGTCGCTCCGGACGAACTCGAACGCTGGTTTCTCTCTCATATTTTTGGTCTGGAAGTCTCAGGGACGGAGGGG
CGCCAAGGCCCCATGTGTGGGAGGATTGTTTCAGCTCCACAAACTTGCACGGATTTTGGTTACTTGTTTGGCCAATGGTTCGGCTCTGAT
TTCTTCCGAATTGTTGCAAATTCGCCATCGTTCCCTGGCTGCTTACTAAGTTGGATCCGGAATTTCTTTTCAACCGGGAGCCATTGGTGT
CGAAGTGTCTGCAATGAACCCCGTGAATGCTACTGCTCTCTACATTTCCGCGAGCCGCCTAGTGCTCAACTACGACCCCGGAGACCCCAA
GGCGTTTACTGAGATTAACAGGCTCTTGCCTTACTTCCGACAGTCCCTTTCGTGCTGTGTTTGCGGTGAAGTGCCAGCATTATAAGAAAA
AACGAACGGAGCAAGAAGAAACTATTGCTTCTTTGCAAATGGAAGTCTGTAGATTAAAAAAGGAGGAAGAAGATCGCATTGTCACTCAAA
ACAGAGTGTTTGCCTATCTGTGCAAAAGAGTTCCTCATACCGTCTTGGATAGACAGTTGCTTTGTCTAATTGATTACTATGAATCTAAAA
TTAGAAAAATTCATACACAAAGGCAATATAAAGAAGATGAAAGTCAGTCAGAAGAAGAAAACGACTACAGAAATCTGGATGCCTCACCAA
CTTATAAAGGCCTTTTAATGTCATTACAGAATCAACTCAAGGAATCAAAATCTAAGATTGATGCACTTTCAAGTGAAAAGCTGAACCTCC
AAAAAGATTTGGAAACCAGGCCTACGCAGCATGAATTAAGACTTTATAAACAGCAGGTGAAGAAGCTGGAAAAAGCCCTTAAGAAAAACG
TCAAATTACAGGAGCTTATTAATCATAAGAAGGCTGAGGACACAGAGAAGAAAGATGAGCCCAGCAAATATAATCAGCAACAGGCCCTAA
TTGACCAGAGATACTTTCAGGTGCTGTGTAGCATCAATTCAATTATCCACAATCCAAGAGCTCCAGTAATAATTTATAAACAGACCAAAG
GGGGAGTCCAAAATTTTAATAAAGATCTTGTTCAAGATTGTGGATTTGAGCATCTTGTTCCTGTAATAGAAATGTGGGCAGATCAACTGA
CATCCTTAAAGGATTTGTATAAGTCCTTGAAAACACTATCTGCAGAACTGGTACCTTGGCTTAATTTGAAGAAGCAGGATGAAAATGAAG
GTATCAAAGTTGAAGATTTGTTGTTTATAGTAGATACTATGCTGGAAGAAGTTGAAAATAAGGAAAAGGACAGCAATATGCCACACTTTC
AAACTTTGCAAGCTATTGTTTCTCACTTCCAAAAGTTATTTGATGTGCCTTCTTTAAATGGAGTCTATCCCCGAATGAATGAAGTTTATA
CTAGGCTTGGAGAAATGAACAATGCTGTGAGAAACCTCCAAGAACTCTTAGAATTAGATAGTTCATCCTCATTGTGTGTGCTAGTAAGCA
CTGTTGGAAAACTCTGTAGGCTGATTAATGAAGATGTGAATGAGCAGGTTATGCAGGTATTAGGACCTGAAGACCTCCAGAGCATTATCT
ACAAATTGGAAGAACACGAGGAATTTTTCCCAGCATTTCAGGCATTTACTAATGATCTACTTGAAATCTTAGAAATTGATGACTTGGATG
CCATTGTACCTGCAGTAAAGAAATTAAAAGTACTTTCATACTGAAAACAAATCAAATCATTTTTACTGTGTAAATTGTATTCTTAACATT
TTGTATTTTGTAGGATTGATCTTATTTTGAGACAAGGGTTGTAAAATGTATTTGCTCTCAGAATTCATCCCCTTCTTAGTATTAGGTCAT
TCTTCATCTGTATAATTTTTATTAACTTTGAGATTCTTATACAGAAAATAGTTGCAAGGGTAAGGTAATTAACTTTAGATCCCTTCATTT
CTAAAGCAATTATTGAGTGCTTAAAATTTAAGGTTGTTTTAGAGTGGAGTTTGTGAGTAAAAGAGGAGCCCAGGGAGACAGATTGCAAGT
AGTAGGTTGCAATCTTTTAGATTCAGCTTGTAATAATCTTTGAGCCACACCAAAAGGAATGCCAAGGGCTCTCTAAATTTAGCCAGTAGG

>55353_55353_5_MSL2-CEP70_MSL2_chr3_135913814_ENST00000309993_CEP70_chr3_138256189_ENST00000542237_length(amino acids)=461AA_BP=19
MRLTGSCLTSDSPFRAVFAVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRK
IHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKL
QELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIHNPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSL
KDLYKSLKTLSAELVPWLNLKKQDENEGIKVEDLLFIVDTMLEEVENKEKDSNMPHFQTLQAIVSHFQKLFDVPSLNGVYPRMNEVYTRL
GEMNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEQVMQVLGPEDLQSIIYKLEEHEEFFPAFQAFTNDLLEILEIDDLDAIV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MSL2-CEP70


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MSL2-CEP70


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MSL2-CEP70


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource