FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MSRA-SPAG11B (FusionGDB2 ID:55415)

Fusion Gene Summary for MSRA-SPAG11B

check button Fusion gene summary
Fusion gene informationFusion gene name: MSRA-SPAG11B
Fusion gene ID: 55415
HgeneTgene
Gene symbol

MSRA

SPAG11B

Gene ID

4482

10407

Gene namemethionine sulfoxide reductase Asperm associated antigen 11B
SynonymsPMSREDDM2B|EP2|EP2C|EP2D|HE2|HE2C|SPAG11|SPAG11A
Cytomap

8p23.1

8p23.1

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial peptide methionine sulfoxide reductasecytosolic methionine-S-sulfoxide reductasepeptide Met(O) reductasepeptide met (O) reductasepeptide-methionine (S)-S-oxide reductasesperm-associated antigen 11BProtein EP2Sperm-associated antigen 11Aepididymal protein 2Bhuman epididymis-specific protein 2sperm antigen HE2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000317173, ENST00000441698, 
ENST00000518255, ENST00000382490, 
ENST00000517594, ENST00000521209, 
ENST00000528246, 		ENST00000317900, 
ENST00000398462, ENST00000458665, 
ENST00000528168, ENST00000297498, 
ENST00000359758, ENST00000361111, 
Fusion gene scores* DoF score12 X 9 X 6=6483 X 4 X 3=36
# samples 133
** MAII scorelog2(13/648*10)=-2.31748218985617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/36*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MSRA [Title/Abstract] AND SPAG11B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMSRA(9912168)-SPAG11B(7320381), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MSRA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SPAG11B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A1KZ-01AMSRAchr8

9912168

-SPAG11Bchr8

7320381

-
ChimerDB4SARCTCGA-DX-A1KZ-01AMSRAchr8

9912168

+SPAG11Bchr8

7320381

-
ChimerDB4SARCTCGA-RN-AAAQ-01AMSRAchr8

9912168

+SPAG11Bchr8

7320381

-


Top

Fusion Gene ORF analysis for MSRA-SPAG11B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000317173ENST00000317900MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
5CDS-intronENST00000317173ENST00000398462MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
5CDS-intronENST00000317173ENST00000458665MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
5CDS-intronENST00000317173ENST00000528168MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
5CDS-intronENST00000441698ENST00000317900MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
5CDS-intronENST00000441698ENST00000398462MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
5CDS-intronENST00000441698ENST00000458665MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
5CDS-intronENST00000441698ENST00000528168MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
5CDS-intronENST00000518255ENST00000317900MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
5CDS-intronENST00000518255ENST00000398462MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
5CDS-intronENST00000518255ENST00000458665MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
5CDS-intronENST00000518255ENST00000528168MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
In-frameENST00000317173ENST00000297498MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
In-frameENST00000317173ENST00000359758MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
In-frameENST00000317173ENST00000361111MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
In-frameENST00000441698ENST00000297498MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
In-frameENST00000441698ENST00000359758MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
In-frameENST00000441698ENST00000361111MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
In-frameENST00000518255ENST00000297498MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
In-frameENST00000518255ENST00000359758MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
In-frameENST00000518255ENST00000361111MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-3CDSENST00000382490ENST00000297498MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-3CDSENST00000382490ENST00000359758MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-3CDSENST00000382490ENST00000361111MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-3CDSENST00000517594ENST00000297498MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-3CDSENST00000517594ENST00000359758MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-3CDSENST00000517594ENST00000361111MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-3CDSENST00000521209ENST00000297498MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-3CDSENST00000521209ENST00000359758MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-3CDSENST00000521209ENST00000361111MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-3CDSENST00000528246ENST00000297498MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-3CDSENST00000528246ENST00000359758MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-3CDSENST00000528246ENST00000361111MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-intronENST00000382490ENST00000317900MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-intronENST00000382490ENST00000398462MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-intronENST00000382490ENST00000458665MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-intronENST00000382490ENST00000528168MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-intronENST00000517594ENST00000317900MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-intronENST00000517594ENST00000398462MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-intronENST00000517594ENST00000458665MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-intronENST00000517594ENST00000528168MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-intronENST00000521209ENST00000317900MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-intronENST00000521209ENST00000398462MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-intronENST00000521209ENST00000458665MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-intronENST00000521209ENST00000528168MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-intronENST00000528246ENST00000317900MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-intronENST00000528246ENST00000398462MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-intronENST00000528246ENST00000458665MSRAchr8

9912168

+SPAG11Bchr8

7320381

-
intron-intronENST00000528246ENST00000528168MSRAchr8

9912168

+SPAG11Bchr8

7320381

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000317173MSRAchr89912168+ENST00000361111SPAG11Bchr87320381-8413914100137
ENST00000317173MSRAchr89912168+ENST00000359758SPAG11Bchr87320381-9193914100137
ENST00000317173MSRAchr89912168+ENST00000297498SPAG11Bchr87320381-9583914100137
ENST00000441698MSRAchr89912168+ENST00000361111SPAG11Bchr87320381-739289147476109
ENST00000441698MSRAchr89912168+ENST00000359758SPAG11Bchr87320381-817289147554135
ENST00000441698MSRAchr89912168+ENST00000297498SPAG11Bchr87320381-856289147539130
ENST00000518255MSRAchr89912168+ENST00000361111SPAG11Bchr87320381-60815816345109
ENST00000518255MSRAchr89912168+ENST00000359758SPAG11Bchr87320381-68615816423135
ENST00000518255MSRAchr89912168+ENST00000297498SPAG11Bchr87320381-72515816408130

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000317173ENST00000361111MSRAchr89912168+SPAG11Bchr87320381-0.21463940.78536063
ENST00000317173ENST00000359758MSRAchr89912168+SPAG11Bchr87320381-0.142474930.8575251
ENST00000317173ENST00000297498MSRAchr89912168+SPAG11Bchr87320381-0.189833540.8101665
ENST00000441698ENST00000361111MSRAchr89912168+SPAG11Bchr87320381-0.204020.79598
ENST00000441698ENST00000359758MSRAchr89912168+SPAG11Bchr87320381-0.116802760.8831972
ENST00000441698ENST00000297498MSRAchr89912168+SPAG11Bchr87320381-0.166247840.83375216
ENST00000518255ENST00000361111MSRAchr89912168+SPAG11Bchr87320381-0.184476510.8155235
ENST00000518255ENST00000359758MSRAchr89912168+SPAG11Bchr87320381-0.119169110.8808309
ENST00000518255ENST00000297498MSRAchr89912168+SPAG11Bchr87320381-0.14294250.8570575

Top

Fusion Genomic Features for MSRA-SPAG11B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for MSRA-SPAG11B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:9912168/chr8:7320381)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for MSRA-SPAG11B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>55415_55415_1_MSRA-SPAG11B_MSRA_chr8_9912168_ENST00000317173_SPAG11B_chr8_7320381_ENST00000297498_length(transcript)=958nt_BP=391nt
GGAACTCGCCGGGCCACACCCCCTGTCCAGGGAAGGAACACGCCCCCGGTGACAGCCGGTACGGCCCCGGGTTTGGGCAACCTCGATTAC
GGGCGGCCTCCAGCCCCGCCAGCAGCGCCCCGCGCCCGCCCGCCCGCGCCCCTGCCGCCCCCCGGTTCCGGCCGCGGACCCCACTCTCTG
CCGTTCCGGCTGCGGCTCCGCTGCCGGTAGCGCCGTCCCCCGGGACCACCCTTCGGCTGGCGCCCTCCCATGCTCTCGGCCACCCGGAGG
GCTTGCCAGCTCCTCCTCCTCCACAGCCTCTTTCCCGTCCCGAGGATGGGCAACTCGGCCTCGAACATCGTCAGCCCCCAGGAGGCCTTG
CCGGGCCGGAAGGAACAGACCCCTGTAGCGGGATCGTCTCAAGCCAGACATGTGAACCACTCAGCCACTGAGGCTCTCGGAGAACTCAGG
GAAAGAGCCCCTGGGCAAGGCACAAACGGGTTTCAGCTGCTACGCCACGCAGTGAAACGGGACCTCTTACCACCGCGCACCCCACCTTAC
CAAGTGCACATCTCTCACCGGGAGGCTCGAGGACCCTCATTTAGGATCTGTGTGGACTTTTTAGGGCCTAGATGGGCCAGGGGATGTTCC
ACCGGGAATTAGAAATACCATCTGCCATATGCAGCAAGGGATCTGCAGACTTTTTTTCTGCCATTCTGGTGAGAAAAAGCGTGACATTTG
CTCTGATCCCTGGAATAGGTGTTGCGTATCAAATACAGATGAAGAAGGAAAAGAGAAACCAGAGATGGATGGCAGATCTGGGATCTAAAA
TATAAGCTCCCGGAAGGCAGGGATGTTGAAGTATCCCAAGGGCTTAAAGGAATGTGTGGCTTATAGTAGGTGTTCAATAAATATTTGTTG

>55415_55415_1_MSRA-SPAG11B_MSRA_chr8_9912168_ENST00000317173_SPAG11B_chr8_7320381_ENST00000297498_length(amino acids)=137AA_BP=
MSGLRRSRYRGLFLPARQGLLGADDVRGRVAHPRDGKEAVEEEELASPPGGREHGRAPAEGWSRGTALPAAEPQPERQRVGSAAGTGGRQ

--------------------------------------------------------------
>55415_55415_2_MSRA-SPAG11B_MSRA_chr8_9912168_ENST00000317173_SPAG11B_chr8_7320381_ENST00000359758_length(transcript)=919nt_BP=391nt
GGAACTCGCCGGGCCACACCCCCTGTCCAGGGAAGGAACACGCCCCCGGTGACAGCCGGTACGGCCCCGGGTTTGGGCAACCTCGATTAC
GGGCGGCCTCCAGCCCCGCCAGCAGCGCCCCGCGCCCGCCCGCCCGCGCCCCTGCCGCCCCCCGGTTCCGGCCGCGGACCCCACTCTCTG
CCGTTCCGGCTGCGGCTCCGCTGCCGGTAGCGCCGTCCCCCGGGACCACCCTTCGGCTGGCGCCCTCCCATGCTCTCGGCCACCCGGAGG
GCTTGCCAGCTCCTCCTCCTCCACAGCCTCTTTCCCGTCCCGAGGATGGGCAACTCGGCCTCGAACATCGTCAGCCCCCAGGAGGCCTTG
CCGGGCCGGAAGGAACAGACCCCTGTAGCGGGATCGTCTCAAGCCAGACATGTGAACCACTCAGCCACTGAGGCTCTCGGAGAACTCAGG
GAAAGAGCCCCTGGGCAAGGCACAAACGGGTTTCAGCTGCTACGCCACGCAGTGAAACGGGACCTCTTACCACCGCGCACCCCACCTTAC
CAAGGGGATGTTCCACCGGGAATTAGAAATACCATCTGCCATATGCAGCAAGGGATCTGCAGACTTTTTTTCTGCCATTCTGGGACAGGC
CAGCAGCACAGACAACGCTGTGGATAAGGAGAGTAGAGACTTCCTCTTCCTGCCTCCTGTCTTCTGGAGTTGTGACCTCAGGGTGGCCCA
GGTGGATCGGCTTCAGAGGCCAGGAGGCAGCTCTCTGCAGCCGAAGAGCAGGAGCCTCACCCAGGGTCTGTGGCTCTGACTAAGCCTGGA
CTGCCTCTCGGCTGTGCTCCATGGACTGGCTCCCCAGGGATCCATGTGAGAGACCGGAGTATGATCCTCAGTGCGAGGACAAATAAAAGT

>55415_55415_2_MSRA-SPAG11B_MSRA_chr8_9912168_ENST00000317173_SPAG11B_chr8_7320381_ENST00000359758_length(amino acids)=137AA_BP=
MSGLRRSRYRGLFLPARQGLLGADDVRGRVAHPRDGKEAVEEEELASPPGGREHGRAPAEGWSRGTALPAAEPQPERQRVGSAAGTGGRQ

--------------------------------------------------------------
>55415_55415_3_MSRA-SPAG11B_MSRA_chr8_9912168_ENST00000317173_SPAG11B_chr8_7320381_ENST00000361111_length(transcript)=841nt_BP=391nt
GGAACTCGCCGGGCCACACCCCCTGTCCAGGGAAGGAACACGCCCCCGGTGACAGCCGGTACGGCCCCGGGTTTGGGCAACCTCGATTAC
GGGCGGCCTCCAGCCCCGCCAGCAGCGCCCCGCGCCCGCCCGCCCGCGCCCCTGCCGCCCCCCGGTTCCGGCCGCGGACCCCACTCTCTG
CCGTTCCGGCTGCGGCTCCGCTGCCGGTAGCGCCGTCCCCCGGGACCACCCTTCGGCTGGCGCCCTCCCATGCTCTCGGCCACCCGGAGG
GCTTGCCAGCTCCTCCTCCTCCACAGCCTCTTTCCCGTCCCGAGGATGGGCAACTCGGCCTCGAACATCGTCAGCCCCCAGGAGGCCTTG
CCGGGCCGGAAGGAACAGACCCCTGTAGCGGGATCGTCTCAAGCCAGACATGTGAACCACTCAGCCACTGAGGCTCTCGGAGAACTCAGG
GAAAGAGCCCCTGGGCAAGGCACAAACGGGTTTCAGCTGCTACGCCACGCAGTGAAACGGGACCTCTTACCACCGCGCACCCCACCTTAC
CAAGGGACAGGCCAGCAGCACAGACAACGCTGTGGATAAGGAGAGTAGAGACTTCCTCTTCCTGCCTCCTGTCTTCTGGAGTTGTGACCT
CAGGGTGGCCCAGGTGGATCGGCTTCAGAGGCCAGGAGGCAGCTCTCTGCAGCCGAAGAGCAGGAGCCTCACCCAGGGTCTGTGGCTCTG
ACTAAGCCTGGACTGCCTCTCGGCTGTGCTCCATGGACTGGCTCCCCAGGGATCCATGTGAGAGACCGGAGTATGATCCTCAGTGCGAGG

>55415_55415_3_MSRA-SPAG11B_MSRA_chr8_9912168_ENST00000317173_SPAG11B_chr8_7320381_ENST00000361111_length(amino acids)=137AA_BP=
MSGLRRSRYRGLFLPARQGLLGADDVRGRVAHPRDGKEAVEEEELASPPGGREHGRAPAEGWSRGTALPAAEPQPERQRVGSAAGTGGRQ

--------------------------------------------------------------
>55415_55415_4_MSRA-SPAG11B_MSRA_chr8_9912168_ENST00000441698_SPAG11B_chr8_7320381_ENST00000297498_length(transcript)=856nt_BP=289nt
GCCCCGCCAGCAGCGCCCCGCGCCCGCCCGCCCGCGCCCCTGCCGCCCCCCGGTTCCGGCCGCGGACCCCACTCTCTGCCGTTCCGGCTG
CGGCTCCGCTGCCGGTAGCGCCGTCCCCCGGGACCACCCTTCGGCTGGCGCCCTCCCATGCTCTCGGCCACCCGGAGGGCTTGCCAGCTC
CTCCTCCTCCACAGCCTCTTTCCCGTCCCGAGGATGGGCAACTCGGCCTCGAACATCGTCAGCCCCCAGGAGGCCTTGCCGGGCCGGAAG
GAACAGACCCCTGTAGCGGGATCGTCTCAAGCCAGACATGTGAACCACTCAGCCACTGAGGCTCTCGGAGAACTCAGGGAAAGAGCCCCT
GGGCAAGGCACAAACGGGTTTCAGCTGCTACGCCACGCAGTGAAACGGGACCTCTTACCACCGCGCACCCCACCTTACCAAGTGCACATC
TCTCACCGGGAGGCTCGAGGACCCTCATTTAGGATCTGTGTGGACTTTTTAGGGCCTAGATGGGCCAGGGGATGTTCCACCGGGAATTAG
AAATACCATCTGCCATATGCAGCAAGGGATCTGCAGACTTTTTTTCTGCCATTCTGGTGAGAAAAAGCGTGACATTTGCTCTGATCCCTG
GAATAGGTGTTGCGTATCAAATACAGATGAAGAAGGAAAAGAGAAACCAGAGATGGATGGCAGATCTGGGATCTAAAATATAAGCTCCCG
GAAGGCAGGGATGTTGAAGTATCCCAAGGGCTTAAAGGAATGTGTGGCTTATAGTAGGTGTTCAATAAATATTTGTTGAATGAATTTAGC

>55415_55415_4_MSRA-SPAG11B_MSRA_chr8_9912168_ENST00000441698_SPAG11B_chr8_7320381_ENST00000297498_length(amino acids)=130AA_BP=47
MLSATRRACQLLLLHSLFPVPRMGNSASNIVSPQEALPGRKEQTPVAGSSQARHVNHSATEALGELRERAPGQGTNGFQLLRHAVKRDLL

--------------------------------------------------------------
>55415_55415_5_MSRA-SPAG11B_MSRA_chr8_9912168_ENST00000441698_SPAG11B_chr8_7320381_ENST00000359758_length(transcript)=817nt_BP=289nt
GCCCCGCCAGCAGCGCCCCGCGCCCGCCCGCCCGCGCCCCTGCCGCCCCCCGGTTCCGGCCGCGGACCCCACTCTCTGCCGTTCCGGCTG
CGGCTCCGCTGCCGGTAGCGCCGTCCCCCGGGACCACCCTTCGGCTGGCGCCCTCCCATGCTCTCGGCCACCCGGAGGGCTTGCCAGCTC
CTCCTCCTCCACAGCCTCTTTCCCGTCCCGAGGATGGGCAACTCGGCCTCGAACATCGTCAGCCCCCAGGAGGCCTTGCCGGGCCGGAAG
GAACAGACCCCTGTAGCGGGATCGTCTCAAGCCAGACATGTGAACCACTCAGCCACTGAGGCTCTCGGAGAACTCAGGGAAAGAGCCCCT
GGGCAAGGCACAAACGGGTTTCAGCTGCTACGCCACGCAGTGAAACGGGACCTCTTACCACCGCGCACCCCACCTTACCAAGGGGATGTT
CCACCGGGAATTAGAAATACCATCTGCCATATGCAGCAAGGGATCTGCAGACTTTTTTTCTGCCATTCTGGGACAGGCCAGCAGCACAGA
CAACGCTGTGGATAAGGAGAGTAGAGACTTCCTCTTCCTGCCTCCTGTCTTCTGGAGTTGTGACCTCAGGGTGGCCCAGGTGGATCGGCT
TCAGAGGCCAGGAGGCAGCTCTCTGCAGCCGAAGAGCAGGAGCCTCACCCAGGGTCTGTGGCTCTGACTAAGCCTGGACTGCCTCTCGGC
TGTGCTCCATGGACTGGCTCCCCAGGGATCCATGTGAGAGACCGGAGTATGATCCTCAGTGCGAGGACAAATAAAAGTAGTGATTATGTC

>55415_55415_5_MSRA-SPAG11B_MSRA_chr8_9912168_ENST00000441698_SPAG11B_chr8_7320381_ENST00000359758_length(amino acids)=135AA_BP=47
MLSATRRACQLLLLHSLFPVPRMGNSASNIVSPQEALPGRKEQTPVAGSSQARHVNHSATEALGELRERAPGQGTNGFQLLRHAVKRDLL

--------------------------------------------------------------
>55415_55415_6_MSRA-SPAG11B_MSRA_chr8_9912168_ENST00000441698_SPAG11B_chr8_7320381_ENST00000361111_length(transcript)=739nt_BP=289nt
GCCCCGCCAGCAGCGCCCCGCGCCCGCCCGCCCGCGCCCCTGCCGCCCCCCGGTTCCGGCCGCGGACCCCACTCTCTGCCGTTCCGGCTG
CGGCTCCGCTGCCGGTAGCGCCGTCCCCCGGGACCACCCTTCGGCTGGCGCCCTCCCATGCTCTCGGCCACCCGGAGGGCTTGCCAGCTC
CTCCTCCTCCACAGCCTCTTTCCCGTCCCGAGGATGGGCAACTCGGCCTCGAACATCGTCAGCCCCCAGGAGGCCTTGCCGGGCCGGAAG
GAACAGACCCCTGTAGCGGGATCGTCTCAAGCCAGACATGTGAACCACTCAGCCACTGAGGCTCTCGGAGAACTCAGGGAAAGAGCCCCT
GGGCAAGGCACAAACGGGTTTCAGCTGCTACGCCACGCAGTGAAACGGGACCTCTTACCACCGCGCACCCCACCTTACCAAGGGACAGGC
CAGCAGCACAGACAACGCTGTGGATAAGGAGAGTAGAGACTTCCTCTTCCTGCCTCCTGTCTTCTGGAGTTGTGACCTCAGGGTGGCCCA
GGTGGATCGGCTTCAGAGGCCAGGAGGCAGCTCTCTGCAGCCGAAGAGCAGGAGCCTCACCCAGGGTCTGTGGCTCTGACTAAGCCTGGA
CTGCCTCTCGGCTGTGCTCCATGGACTGGCTCCCCAGGGATCCATGTGAGAGACCGGAGTATGATCCTCAGTGCGAGGACAAATAAAAGT

>55415_55415_6_MSRA-SPAG11B_MSRA_chr8_9912168_ENST00000441698_SPAG11B_chr8_7320381_ENST00000361111_length(amino acids)=109AA_BP=47
MLSATRRACQLLLLHSLFPVPRMGNSASNIVSPQEALPGRKEQTPVAGSSQARHVNHSATEALGELRERAPGQGTNGFQLLRHAVKRDLL

--------------------------------------------------------------
>55415_55415_7_MSRA-SPAG11B_MSRA_chr8_9912168_ENST00000518255_SPAG11B_chr8_7320381_ENST00000297498_length(transcript)=725nt_BP=158nt
CGGCTGGCGCCCTCCCATGCTCTCGGCCACCCGGAGGGCTTGCCAGCTCCTCCTCCTCCACAGCCTCTTTCCCGTCCCGAGGATGGGCAA
CTCGGCCTCGAACATCGTCAGCCCCCAGGAGGCCTTGCCGGGCCGGAAGGAACAGACCCCTGTAGCGGGATCGTCTCAAGCCAGACATGT
GAACCACTCAGCCACTGAGGCTCTCGGAGAACTCAGGGAAAGAGCCCCTGGGCAAGGCACAAACGGGTTTCAGCTGCTACGCCACGCAGT
GAAACGGGACCTCTTACCACCGCGCACCCCACCTTACCAAGTGCACATCTCTCACCGGGAGGCTCGAGGACCCTCATTTAGGATCTGTGT
GGACTTTTTAGGGCCTAGATGGGCCAGGGGATGTTCCACCGGGAATTAGAAATACCATCTGCCATATGCAGCAAGGGATCTGCAGACTTT
TTTTCTGCCATTCTGGTGAGAAAAAGCGTGACATTTGCTCTGATCCCTGGAATAGGTGTTGCGTATCAAATACAGATGAAGAAGGAAAAG
AGAAACCAGAGATGGATGGCAGATCTGGGATCTAAAATATAAGCTCCCGGAAGGCAGGGATGTTGAAGTATCCCAAGGGCTTAAAGGAAT
GTGTGGCTTATAGTAGGTGTTCAATAAATATTTGTTGAATGAATTTAGCACCAAAGGTGAAGAGCTGATAAAAGACATTTTTTTAACTTC

>55415_55415_7_MSRA-SPAG11B_MSRA_chr8_9912168_ENST00000518255_SPAG11B_chr8_7320381_ENST00000297498_length(amino acids)=130AA_BP=47
MLSATRRACQLLLLHSLFPVPRMGNSASNIVSPQEALPGRKEQTPVAGSSQARHVNHSATEALGELRERAPGQGTNGFQLLRHAVKRDLL

--------------------------------------------------------------
>55415_55415_8_MSRA-SPAG11B_MSRA_chr8_9912168_ENST00000518255_SPAG11B_chr8_7320381_ENST00000359758_length(transcript)=686nt_BP=158nt
CGGCTGGCGCCCTCCCATGCTCTCGGCCACCCGGAGGGCTTGCCAGCTCCTCCTCCTCCACAGCCTCTTTCCCGTCCCGAGGATGGGCAA
CTCGGCCTCGAACATCGTCAGCCCCCAGGAGGCCTTGCCGGGCCGGAAGGAACAGACCCCTGTAGCGGGATCGTCTCAAGCCAGACATGT
GAACCACTCAGCCACTGAGGCTCTCGGAGAACTCAGGGAAAGAGCCCCTGGGCAAGGCACAAACGGGTTTCAGCTGCTACGCCACGCAGT
GAAACGGGACCTCTTACCACCGCGCACCCCACCTTACCAAGGGGATGTTCCACCGGGAATTAGAAATACCATCTGCCATATGCAGCAAGG
GATCTGCAGACTTTTTTTCTGCCATTCTGGGACAGGCCAGCAGCACAGACAACGCTGTGGATAAGGAGAGTAGAGACTTCCTCTTCCTGC
CTCCTGTCTTCTGGAGTTGTGACCTCAGGGTGGCCCAGGTGGATCGGCTTCAGAGGCCAGGAGGCAGCTCTCTGCAGCCGAAGAGCAGGA
GCCTCACCCAGGGTCTGTGGCTCTGACTAAGCCTGGACTGCCTCTCGGCTGTGCTCCATGGACTGGCTCCCCAGGGATCCATGTGAGAGA

>55415_55415_8_MSRA-SPAG11B_MSRA_chr8_9912168_ENST00000518255_SPAG11B_chr8_7320381_ENST00000359758_length(amino acids)=135AA_BP=47
MLSATRRACQLLLLHSLFPVPRMGNSASNIVSPQEALPGRKEQTPVAGSSQARHVNHSATEALGELRERAPGQGTNGFQLLRHAVKRDLL

--------------------------------------------------------------
>55415_55415_9_MSRA-SPAG11B_MSRA_chr8_9912168_ENST00000518255_SPAG11B_chr8_7320381_ENST00000361111_length(transcript)=608nt_BP=158nt
CGGCTGGCGCCCTCCCATGCTCTCGGCCACCCGGAGGGCTTGCCAGCTCCTCCTCCTCCACAGCCTCTTTCCCGTCCCGAGGATGGGCAA
CTCGGCCTCGAACATCGTCAGCCCCCAGGAGGCCTTGCCGGGCCGGAAGGAACAGACCCCTGTAGCGGGATCGTCTCAAGCCAGACATGT
GAACCACTCAGCCACTGAGGCTCTCGGAGAACTCAGGGAAAGAGCCCCTGGGCAAGGCACAAACGGGTTTCAGCTGCTACGCCACGCAGT
GAAACGGGACCTCTTACCACCGCGCACCCCACCTTACCAAGGGACAGGCCAGCAGCACAGACAACGCTGTGGATAAGGAGAGTAGAGACT
TCCTCTTCCTGCCTCCTGTCTTCTGGAGTTGTGACCTCAGGGTGGCCCAGGTGGATCGGCTTCAGAGGCCAGGAGGCAGCTCTCTGCAGC
CGAAGAGCAGGAGCCTCACCCAGGGTCTGTGGCTCTGACTAAGCCTGGACTGCCTCTCGGCTGTGCTCCATGGACTGGCTCCCCAGGGAT

>55415_55415_9_MSRA-SPAG11B_MSRA_chr8_9912168_ENST00000518255_SPAG11B_chr8_7320381_ENST00000361111_length(amino acids)=109AA_BP=47
MLSATRRACQLLLLHSLFPVPRMGNSASNIVSPQEALPGRKEQTPVAGSSQARHVNHSATEALGELRERAPGQGTNGFQLLRHAVKRDLL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MSRA-SPAG11B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MSRA-SPAG11B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for MSRA-SPAG11B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource