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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MSRB3-CCDC57 (FusionGDB2 ID:55424)

Fusion Gene Summary for MSRB3-CCDC57

check button Fusion gene summary
Fusion gene informationFusion gene name: MSRB3-CCDC57
Fusion gene ID: 55424
HgeneTgene
Gene symbol

MSRB3

CCDC57

Gene ID

253827

284001

Gene namemethionine sulfoxide reductase B3coiled-coil domain containing 57
SynonymsDFNB74-
Cytomap

12q14.3

17q25.3

Type of geneprotein-codingprotein-coding
Descriptionmethionine-R-sulfoxide reductase B3methionine-R-sulfoxide reductase B3, mitochondrialcoiled-coil domain-containing protein 57
Modification date2020031320200313
UniProtAcc

Q8IXL7

Q2TAC2

Ensembl transtripts involved in fusion geneENST00000308259, ENST00000355192, 
ENST00000535664, ENST00000540804, 
ENST00000538725, 		ENST00000327026, 
ENST00000392343, ENST00000392346, 
ENST00000389641, ENST00000392347, 
Fusion gene scores* DoF score7 X 5 X 4=14019 X 12 X 13=2964
# samples 722
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/2964*10)=-3.75197001878117
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MSRB3 [Title/Abstract] AND CCDC57 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMSRB3(65847605)-CCDC57(80059742), # samples:1
Anticipated loss of major functional domain due to fusion event.MSRB3-CCDC57 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMSRB3

GO:0030091

protein repair

14699060


check buttonFusion gene breakpoints across MSRB3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCDC57 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A3U6-01AMSRB3chr12

65847605

+CCDC57chr17

80059742

-


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Fusion Gene ORF analysis for MSRB3-CCDC57

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000308259ENST00000327026MSRB3chr12

65847605

+CCDC57chr17

80059742

-
5CDS-intronENST00000308259ENST00000392343MSRB3chr12

65847605

+CCDC57chr17

80059742

-
5CDS-intronENST00000308259ENST00000392346MSRB3chr12

65847605

+CCDC57chr17

80059742

-
5CDS-intronENST00000355192ENST00000327026MSRB3chr12

65847605

+CCDC57chr17

80059742

-
5CDS-intronENST00000355192ENST00000392343MSRB3chr12

65847605

+CCDC57chr17

80059742

-
5CDS-intronENST00000355192ENST00000392346MSRB3chr12

65847605

+CCDC57chr17

80059742

-
5CDS-intronENST00000535664ENST00000327026MSRB3chr12

65847605

+CCDC57chr17

80059742

-
5CDS-intronENST00000535664ENST00000392343MSRB3chr12

65847605

+CCDC57chr17

80059742

-
5CDS-intronENST00000535664ENST00000392346MSRB3chr12

65847605

+CCDC57chr17

80059742

-
5CDS-intronENST00000540804ENST00000327026MSRB3chr12

65847605

+CCDC57chr17

80059742

-
5CDS-intronENST00000540804ENST00000392343MSRB3chr12

65847605

+CCDC57chr17

80059742

-
5CDS-intronENST00000540804ENST00000392346MSRB3chr12

65847605

+CCDC57chr17

80059742

-
Frame-shiftENST00000540804ENST00000389641MSRB3chr12

65847605

+CCDC57chr17

80059742

-
Frame-shiftENST00000540804ENST00000392347MSRB3chr12

65847605

+CCDC57chr17

80059742

-
In-frameENST00000308259ENST00000389641MSRB3chr12

65847605

+CCDC57chr17

80059742

-
In-frameENST00000308259ENST00000392347MSRB3chr12

65847605

+CCDC57chr17

80059742

-
In-frameENST00000355192ENST00000389641MSRB3chr12

65847605

+CCDC57chr17

80059742

-
In-frameENST00000355192ENST00000392347MSRB3chr12

65847605

+CCDC57chr17

80059742

-
In-frameENST00000535664ENST00000389641MSRB3chr12

65847605

+CCDC57chr17

80059742

-
In-frameENST00000535664ENST00000392347MSRB3chr12

65847605

+CCDC57chr17

80059742

-
intron-3CDSENST00000538725ENST00000389641MSRB3chr12

65847605

+CCDC57chr17

80059742

-
intron-3CDSENST00000538725ENST00000392347MSRB3chr12

65847605

+CCDC57chr17

80059742

-
intron-intronENST00000538725ENST00000327026MSRB3chr12

65847605

+CCDC57chr17

80059742

-
intron-intronENST00000538725ENST00000392343MSRB3chr12

65847605

+CCDC57chr17

80059742

-
intron-intronENST00000538725ENST00000392346MSRB3chr12

65847605

+CCDC57chr17

80059742

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355192MSRB3chr1265847605+ENST00000392347CCDC57chr1780059742-934537111608165
ENST00000355192MSRB3chr1265847605+ENST00000389641CCDC57chr1780059742-934537111608165
ENST00000308259MSRB3chr1265847605+ENST00000392347CCDC57chr1780059742-1061664226735169
ENST00000308259MSRB3chr1265847605+ENST00000389641CCDC57chr1780059742-1061664226735169
ENST00000535664MSRB3chr1265847605+ENST00000392347CCDC57chr1780059742-1126729291800169
ENST00000535664MSRB3chr1265847605+ENST00000389641CCDC57chr1780059742-1126729291800169

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355192ENST00000392347MSRB3chr1265847605+CCDC57chr1780059742-0.0964386760.9035613
ENST00000355192ENST00000389641MSRB3chr1265847605+CCDC57chr1780059742-0.0964386760.9035613
ENST00000308259ENST00000392347MSRB3chr1265847605+CCDC57chr1780059742-0.0525412340.9474588
ENST00000308259ENST00000389641MSRB3chr1265847605+CCDC57chr1780059742-0.0525412340.9474588
ENST00000535664ENST00000392347MSRB3chr1265847605+CCDC57chr1780059742-0.046497550.9535025
ENST00000535664ENST00000389641MSRB3chr1265847605+CCDC57chr1780059742-0.046497550.9535025

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Fusion Genomic Features for MSRB3-CCDC57


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MSRB3-CCDC57


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:65847605/chr17:80059742)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MSRB3

Q8IXL7

CCDC57

Q2TAC2

FUNCTION: Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing. {ECO:0000269|PubMed:14699060, ECO:0000269|PubMed:21185009}.FUNCTION: Pleiotropic regulator of centriole duplication, mitosis, and ciliogenesis. Critical interface between centrosome and microtubule-mediated cellular processes. Centriole duplication protein required for recruitment of CEP63, CEP152, and PLK4 to the centrosome. Independent of its centrosomal targeting, localizes to and interacts with microtubules and regulates microtubule nucleation, stability, and mitotic progression. {ECO:0000269|PubMed:32402286}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCCDC57chr12:65847605chr17:80059742ENST00000392343015214_4220752.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC57chr12:65847605chr17:80059742ENST00000392343015456_4830752.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC57chr12:65847605chr17:80059742ENST00000392343015521_5480752.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC57chr12:65847605chr17:80059742ENST0000039234301592_1730752.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC57chr12:65847605chr17:80059742ENST000003923430151_5020752.0RegionCentrosomal targeting domain
TgeneCCDC57chr12:65847605chr17:80059742ENST00000392343015606_9150752.0RegionMicrotubule binding domain

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMSRB3chr12:65847605chr17:80059742ENST00000308259+6747_169130186.0DomainMsrB
HgeneMSRB3chr12:65847605chr17:80059742ENST00000355192+5647_169137193.0DomainMsrB
HgeneMSRB3chr12:65847605chr17:80059742ENST00000535664+7847_169130186.0DomainMsrB
HgeneMSRB3chr12:65847605chr17:80059742ENST00000308259+67189_192130186.0MotifEndoplasmic reticulum retention signal
HgeneMSRB3chr12:65847605chr17:80059742ENST00000355192+56189_192137193.0MotifEndoplasmic reticulum retention signal
HgeneMSRB3chr12:65847605chr17:80059742ENST00000535664+78189_192130186.0MotifEndoplasmic reticulum retention signal
TgeneCCDC57chr12:65847605chr17:80059742ENST000003896411618214_422855917.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC57chr12:65847605chr17:80059742ENST000003896411618456_483855917.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC57chr12:65847605chr17:80059742ENST000003896411618521_548855917.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC57chr12:65847605chr17:80059742ENST00000389641161892_173855917.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC57chr12:65847605chr17:80059742ENST000003923471517214_422855917.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC57chr12:65847605chr17:80059742ENST000003923471517456_483855917.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC57chr12:65847605chr17:80059742ENST000003923471517521_548855917.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC57chr12:65847605chr17:80059742ENST00000392347151792_173855917.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC57chr12:65847605chr17:80059742ENST0000038964116181_502855917.0RegionCentrosomal targeting domain
TgeneCCDC57chr12:65847605chr17:80059742ENST000003896411618606_915855917.0RegionMicrotubule binding domain
TgeneCCDC57chr12:65847605chr17:80059742ENST0000039234715171_502855917.0RegionCentrosomal targeting domain
TgeneCCDC57chr12:65847605chr17:80059742ENST000003923471517606_915855917.0RegionMicrotubule binding domain


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Fusion Gene Sequence for MSRB3-CCDC57


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>55424_55424_1_MSRB3-CCDC57_MSRB3_chr12_65847605_ENST00000308259_CCDC57_chr17_80059742_ENST00000389641_length(transcript)=1061nt_BP=664nt
ATATTTGGACTCGGCTGCCCGTGCCCAGGAATTTCCCGTCATGCCTCCCGCCGCCCCGTCCGTCGCCCGGAGCCGGGGAGGGAGGGAGCG
AGGTTCGGACACCGGCGGCGGCTGCCTGGCCTTTCCATGAGCCCGCGGCGGACCCTCCCGCGCCCCCTCTCGCTCTGCCTCTCCCTCTGC
CTCTGCCTCTGCCTGGCCGCGGCTCTGGGAAGTGCGCAGTCCGCTCTTGCCCCTGTTCTTTGCTTCTCGTTTTGTTGGTGAAGATATCAC
AGTGATGTCTGCATTCAACCTGCTGCATTTGGTGACAAAGAGCCAGCCAGTAGCCCTTCGAGCCTGTGGGCTTCCCTCAGGGTCGTGTAG
GGATAAAAAGAACTGTAAGGTGGTCTTTTCCCAGCAGGAACTGAGGAAGCGGCTAACACCCCTGCAGTACCATGTCACTCAGGAGAAAGG
GACCGAAAGTGCCTTTGAAGGAGAATACACACATCACAAAGATCCTGGAATATATAAATGTGTTGTTTGTGGAACTCCATTGTTTAAGTC
AGAAACCAAATTTGACTCCGGTTCAGGTTGGCCTTCATTCCACGATGTGATCAATTCTGAGGCAATCACATTCACAGATGACTTTTCCTA
TGGGATGCACAGGGTGGAAACAAGCTGCTCTCAGAGCTCCCAGCTCCTCCAGCAGCCGACAGGAGGCCCGTCAAGATGCAGGCAGGCATT
GCCACCCCAGGGATGAAGACAGCAGCCCAGGCAAAGGCCAAGACCACAGGAGCCTCCCGGTCTCATCCTGCAAAAGCTAAAGGCTGCCAG
AGGCCCCCCAAGATCCGTAACTACAACATTATGGACTGACTTCCTCCCCCCACCCCGCCCCACTAAGGGGTGCTCGGGGCCTCCGCATGG
TGCCTGTGCTTTCACCTACGTGTTGTGGGGGGGTGTGGGCACAGCGTGCAGGGTGGAGGCAGGGAGCTGCAGGGCAGGCTCCCAAATGCT

>55424_55424_1_MSRB3-CCDC57_MSRB3_chr12_65847605_ENST00000308259_CCDC57_chr17_80059742_ENST00000389641_length(amino acids)=169AA_BP=145
MPLFFASRFVGEDITVMSAFNLLHLVTKSQPVALRACGLPSGSCRDKKNCKVVFSQQELRKRLTPLQYHVTQEKGTESAFEGEYTHHKDP

--------------------------------------------------------------
>55424_55424_2_MSRB3-CCDC57_MSRB3_chr12_65847605_ENST00000308259_CCDC57_chr17_80059742_ENST00000392347_length(transcript)=1061nt_BP=664nt
ATATTTGGACTCGGCTGCCCGTGCCCAGGAATTTCCCGTCATGCCTCCCGCCGCCCCGTCCGTCGCCCGGAGCCGGGGAGGGAGGGAGCG
AGGTTCGGACACCGGCGGCGGCTGCCTGGCCTTTCCATGAGCCCGCGGCGGACCCTCCCGCGCCCCCTCTCGCTCTGCCTCTCCCTCTGC
CTCTGCCTCTGCCTGGCCGCGGCTCTGGGAAGTGCGCAGTCCGCTCTTGCCCCTGTTCTTTGCTTCTCGTTTTGTTGGTGAAGATATCAC
AGTGATGTCTGCATTCAACCTGCTGCATTTGGTGACAAAGAGCCAGCCAGTAGCCCTTCGAGCCTGTGGGCTTCCCTCAGGGTCGTGTAG
GGATAAAAAGAACTGTAAGGTGGTCTTTTCCCAGCAGGAACTGAGGAAGCGGCTAACACCCCTGCAGTACCATGTCACTCAGGAGAAAGG
GACCGAAAGTGCCTTTGAAGGAGAATACACACATCACAAAGATCCTGGAATATATAAATGTGTTGTTTGTGGAACTCCATTGTTTAAGTC
AGAAACCAAATTTGACTCCGGTTCAGGTTGGCCTTCATTCCACGATGTGATCAATTCTGAGGCAATCACATTCACAGATGACTTTTCCTA
TGGGATGCACAGGGTGGAAACAAGCTGCTCTCAGAGCTCCCAGCTCCTCCAGCAGCCGACAGGAGGCCCGTCAAGATGCAGGCAGGCATT
GCCACCCCAGGGATGAAGACAGCAGCCCAGGCAAAGGCCAAGACCACAGGAGCCTCCCGGTCTCATCCTGCAAAAGCTAAAGGCTGCCAG
AGGCCCCCCAAGATCCGTAACTACAACATTATGGACTGACTTCCTCCCCCCACCCCGCCCCACTAAGGGGTGCTCGGGGCCTCCGCATGG
TGCCTGTGCTTTCACCTACGTGTTGTGGGGGGGTGTGGGCACAGCGTGCAGGGTGGAGGCAGGGAGCTGCAGGGCAGGCTCCCAAATGCT

>55424_55424_2_MSRB3-CCDC57_MSRB3_chr12_65847605_ENST00000308259_CCDC57_chr17_80059742_ENST00000392347_length(amino acids)=169AA_BP=145
MPLFFASRFVGEDITVMSAFNLLHLVTKSQPVALRACGLPSGSCRDKKNCKVVFSQQELRKRLTPLQYHVTQEKGTESAFEGEYTHHKDP

--------------------------------------------------------------
>55424_55424_3_MSRB3-CCDC57_MSRB3_chr12_65847605_ENST00000355192_CCDC57_chr17_80059742_ENST00000389641_length(transcript)=934nt_BP=537nt
ATATTTGGACTCGGCTGCCCGTGCCCAGGAATTTCCCGTCATGCCTCCCGCCGCCCCGTCCGTCGCCCGGAGCCGGGGAGGGAGGGAGCG
AGGTTCGGACACCGGCGGCGGCTGCCTGGCCTTTCCATGAGCCCGCGGCGGACCCTCCCGCGCCCCCTCTCGCTCTGCCTCTCCCTCTGC
CTCTGCCTCTGCCTGGCCGCGGCTCTGGGAAGTGCGCAGTCCGGGTCGTGTAGGGATAAAAAGAACTGTAAGGTGGTCTTTTCCCAGCAG
GAACTGAGGAAGCGGCTAACACCCCTGCAGTACCATGTCACTCAGGAGAAAGGGACCGAAAGTGCCTTTGAAGGAGAATACACACATCAC
AAAGATCCTGGAATATATAAATGTGTTGTTTGTGGAACTCCATTGTTTAAGTCAGAAACCAAATTTGACTCCGGTTCAGGTTGGCCTTCA
TTCCACGATGTGATCAATTCTGAGGCAATCACATTCACAGATGACTTTTCCTATGGGATGCACAGGGTGGAAACAAGCTGCTCTCAGAGC
TCCCAGCTCCTCCAGCAGCCGACAGGAGGCCCGTCAAGATGCAGGCAGGCATTGCCACCCCAGGGATGAAGACAGCAGCCCAGGCAAAGG
CCAAGACCACAGGAGCCTCCCGGTCTCATCCTGCAAAAGCTAAAGGCTGCCAGAGGCCCCCCAAGATCCGTAACTACAACATTATGGACT
GACTTCCTCCCCCCACCCCGCCCCACTAAGGGGTGCTCGGGGCCTCCGCATGGTGCCTGTGCTTTCACCTACGTGTTGTGGGGGGGTGTG
GGCACAGCGTGCAGGGTGGAGGCAGGGAGCTGCAGGGCAGGCTCCCAAATGCTGCTGAGGCGACCCTGCTGACTGAAGGCCTCCCTGAGC

>55424_55424_3_MSRB3-CCDC57_MSRB3_chr12_65847605_ENST00000355192_CCDC57_chr17_80059742_ENST00000389641_length(amino acids)=165AA_BP=13
MPGLSMSPRRTLPRPLSLCLSLCLCLCLAAALGSAQSGSCRDKKNCKVVFSQQELRKRLTPLQYHVTQEKGTESAFEGEYTHHKDPGIYK

--------------------------------------------------------------
>55424_55424_4_MSRB3-CCDC57_MSRB3_chr12_65847605_ENST00000355192_CCDC57_chr17_80059742_ENST00000392347_length(transcript)=934nt_BP=537nt
ATATTTGGACTCGGCTGCCCGTGCCCAGGAATTTCCCGTCATGCCTCCCGCCGCCCCGTCCGTCGCCCGGAGCCGGGGAGGGAGGGAGCG
AGGTTCGGACACCGGCGGCGGCTGCCTGGCCTTTCCATGAGCCCGCGGCGGACCCTCCCGCGCCCCCTCTCGCTCTGCCTCTCCCTCTGC
CTCTGCCTCTGCCTGGCCGCGGCTCTGGGAAGTGCGCAGTCCGGGTCGTGTAGGGATAAAAAGAACTGTAAGGTGGTCTTTTCCCAGCAG
GAACTGAGGAAGCGGCTAACACCCCTGCAGTACCATGTCACTCAGGAGAAAGGGACCGAAAGTGCCTTTGAAGGAGAATACACACATCAC
AAAGATCCTGGAATATATAAATGTGTTGTTTGTGGAACTCCATTGTTTAAGTCAGAAACCAAATTTGACTCCGGTTCAGGTTGGCCTTCA
TTCCACGATGTGATCAATTCTGAGGCAATCACATTCACAGATGACTTTTCCTATGGGATGCACAGGGTGGAAACAAGCTGCTCTCAGAGC
TCCCAGCTCCTCCAGCAGCCGACAGGAGGCCCGTCAAGATGCAGGCAGGCATTGCCACCCCAGGGATGAAGACAGCAGCCCAGGCAAAGG
CCAAGACCACAGGAGCCTCCCGGTCTCATCCTGCAAAAGCTAAAGGCTGCCAGAGGCCCCCCAAGATCCGTAACTACAACATTATGGACT
GACTTCCTCCCCCCACCCCGCCCCACTAAGGGGTGCTCGGGGCCTCCGCATGGTGCCTGTGCTTTCACCTACGTGTTGTGGGGGGGTGTG
GGCACAGCGTGCAGGGTGGAGGCAGGGAGCTGCAGGGCAGGCTCCCAAATGCTGCTGAGGCGACCCTGCTGACTGAAGGCCTCCCTGAGC

>55424_55424_4_MSRB3-CCDC57_MSRB3_chr12_65847605_ENST00000355192_CCDC57_chr17_80059742_ENST00000392347_length(amino acids)=165AA_BP=13
MPGLSMSPRRTLPRPLSLCLSLCLCLCLAAALGSAQSGSCRDKKNCKVVFSQQELRKRLTPLQYHVTQEKGTESAFEGEYTHHKDPGIYK

--------------------------------------------------------------
>55424_55424_5_MSRB3-CCDC57_MSRB3_chr12_65847605_ENST00000535664_CCDC57_chr17_80059742_ENST00000389641_length(transcript)=1126nt_BP=729nt
CACCGGCGGCGGCTGCCTGGCCTTTCCATGAGCCCGCGGCGGACCCTCCCGCGCCCCCTCTCGCTCTGCCTCTCCCTCTGCCTCTGCCTC
TGCCTGGCCGCGGCTCTGGGAAGTGCGCAGTCCGAGTGACATCACTGCCTCTCTTCCTGTGCGCTGGCTTTGACATAAGCCAGATGGCCA
CCGTGGTTGGTAGGCGCCCAGGCTGCCTGGTACAGGAGTTGATGAAACAGAATAGGAAGACGTTTTATGGTCAGCTGTGGAAGCACAGTG
AGACTGCAGCTTTGCTAACTCTTGCCCCTGTTCTTTGCTTCTCGTTTTGTTGGTGAAGATATCACAGTGATGTCTGCATTCAACCTGCTG
CATTTGGTGACAAAGAGCCAGCCAGTAGCCCTTCGAGCCTGTGGGCTTCCCTCAGGGTCGTGTAGGGATAAAAAGAACTGTAAGGTGGTC
TTTTCCCAGCAGGAACTGAGGAAGCGGCTAACACCCCTGCAGTACCATGTCACTCAGGAGAAAGGGACCGAAAGTGCCTTTGAAGGAGAA
TACACACATCACAAAGATCCTGGAATATATAAATGTGTTGTTTGTGGAACTCCATTGTTTAAGTCAGAAACCAAATTTGACTCCGGTTCA
GGTTGGCCTTCATTCCACGATGTGATCAATTCTGAGGCAATCACATTCACAGATGACTTTTCCTATGGGATGCACAGGGTGGAAACAAGC
TGCTCTCAGAGCTCCCAGCTCCTCCAGCAGCCGACAGGAGGCCCGTCAAGATGCAGGCAGGCATTGCCACCCCAGGGATGAAGACAGCAG
CCCAGGCAAAGGCCAAGACCACAGGAGCCTCCCGGTCTCATCCTGCAAAAGCTAAAGGCTGCCAGAGGCCCCCCAAGATCCGTAACTACA
ACATTATGGACTGACTTCCTCCCCCCACCCCGCCCCACTAAGGGGTGCTCGGGGCCTCCGCATGGTGCCTGTGCTTTCACCTACGTGTTG
TGGGGGGGTGTGGGCACAGCGTGCAGGGTGGAGGCAGGGAGCTGCAGGGCAGGCTCCCAAATGCTGCTGAGGCGACCCTGCTGACTGAAG

>55424_55424_5_MSRB3-CCDC57_MSRB3_chr12_65847605_ENST00000535664_CCDC57_chr17_80059742_ENST00000389641_length(amino acids)=169AA_BP=145
MPLFFASRFVGEDITVMSAFNLLHLVTKSQPVALRACGLPSGSCRDKKNCKVVFSQQELRKRLTPLQYHVTQEKGTESAFEGEYTHHKDP

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>55424_55424_6_MSRB3-CCDC57_MSRB3_chr12_65847605_ENST00000535664_CCDC57_chr17_80059742_ENST00000392347_length(transcript)=1126nt_BP=729nt
CACCGGCGGCGGCTGCCTGGCCTTTCCATGAGCCCGCGGCGGACCCTCCCGCGCCCCCTCTCGCTCTGCCTCTCCCTCTGCCTCTGCCTC
TGCCTGGCCGCGGCTCTGGGAAGTGCGCAGTCCGAGTGACATCACTGCCTCTCTTCCTGTGCGCTGGCTTTGACATAAGCCAGATGGCCA
CCGTGGTTGGTAGGCGCCCAGGCTGCCTGGTACAGGAGTTGATGAAACAGAATAGGAAGACGTTTTATGGTCAGCTGTGGAAGCACAGTG
AGACTGCAGCTTTGCTAACTCTTGCCCCTGTTCTTTGCTTCTCGTTTTGTTGGTGAAGATATCACAGTGATGTCTGCATTCAACCTGCTG
CATTTGGTGACAAAGAGCCAGCCAGTAGCCCTTCGAGCCTGTGGGCTTCCCTCAGGGTCGTGTAGGGATAAAAAGAACTGTAAGGTGGTC
TTTTCCCAGCAGGAACTGAGGAAGCGGCTAACACCCCTGCAGTACCATGTCACTCAGGAGAAAGGGACCGAAAGTGCCTTTGAAGGAGAA
TACACACATCACAAAGATCCTGGAATATATAAATGTGTTGTTTGTGGAACTCCATTGTTTAAGTCAGAAACCAAATTTGACTCCGGTTCA
GGTTGGCCTTCATTCCACGATGTGATCAATTCTGAGGCAATCACATTCACAGATGACTTTTCCTATGGGATGCACAGGGTGGAAACAAGC
TGCTCTCAGAGCTCCCAGCTCCTCCAGCAGCCGACAGGAGGCCCGTCAAGATGCAGGCAGGCATTGCCACCCCAGGGATGAAGACAGCAG
CCCAGGCAAAGGCCAAGACCACAGGAGCCTCCCGGTCTCATCCTGCAAAAGCTAAAGGCTGCCAGAGGCCCCCCAAGATCCGTAACTACA
ACATTATGGACTGACTTCCTCCCCCCACCCCGCCCCACTAAGGGGTGCTCGGGGCCTCCGCATGGTGCCTGTGCTTTCACCTACGTGTTG
TGGGGGGGTGTGGGCACAGCGTGCAGGGTGGAGGCAGGGAGCTGCAGGGCAGGCTCCCAAATGCTGCTGAGGCGACCCTGCTGACTGAAG

>55424_55424_6_MSRB3-CCDC57_MSRB3_chr12_65847605_ENST00000535664_CCDC57_chr17_80059742_ENST00000392347_length(amino acids)=169AA_BP=145
MPLFFASRFVGEDITVMSAFNLLHLVTKSQPVALRACGLPSGSCRDKKNCKVVFSQQELRKRLTPLQYHVTQEKGTESAFEGEYTHHKDP

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Fusion Gene PPI Analysis for MSRB3-CCDC57


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MSRB3-CCDC57


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MSRB3-CCDC57


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource