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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MTA1-MTA1 (FusionGDB2 ID:55479)

Fusion Gene Summary for MTA1-MTA1

check button Fusion gene summary
Fusion gene informationFusion gene name: MTA1-MTA1
Fusion gene ID: 55479
HgeneTgene
Gene symbol

MTA1

MTA1

Gene ID

9112

9112

Gene namemetastasis associated 1metastasis associated 1
Synonyms--
Cytomap

14q32.33

14q32.33

Type of geneprotein-codingprotein-coding
Descriptionmetastasis-associated protein MTA1metastasis associated gene 1 proteinmetastasis-associated protein MTA1metastasis associated gene 1 protein
Modification date2020031320200313
UniProtAcc.

Q13330

Ensembl transtripts involved in fusion geneENST00000331320, ENST00000405646, 
ENST00000406191, ENST00000435036, 
ENST00000331320, ENST00000405646, 
ENST00000406191, ENST00000435036, 
Fusion gene scores* DoF score4 X 7 X 5=1406 X 9 X 5=270
# samples 910
** MAII scorelog2(9/140*10)=-0.637429920615292
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/270*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MTA1 [Title/Abstract] AND MTA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMTA1(105935291)-MTA1(105934539), # samples:1
MTA1(105930788)-MTA1(105931052), # samples:1
MTA1(105936993)-MTA1(105936971), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMTA1

GO:0010212

response to ionizing radiation

19805145

HgeneMTA1

GO:1902499

positive regulation of protein autoubiquitination

19805145

TgeneMTA1

GO:0010212

response to ionizing radiation

19805145

TgeneMTA1

GO:1902499

positive regulation of protein autoubiquitination

19805145


check buttonFusion gene breakpoints across MTA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MTA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA460861MTA1chr14

105935291

+MTA1chr14

105934539

+
ChiTaRS5.0N/ABE159770MTA1chr14

105930788

+MTA1chr14

105931052

-
ChiTaRS5.0N/AEC505603MTA1chr14

105936993

+MTA1chr14

105936971

-


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Fusion Gene ORF analysis for MTA1-MTA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000331320ENST00000331320MTA1chr14

105936993

+MTA1chr14

105936971

-
3UTR-3UTRENST00000331320ENST00000405646MTA1chr14

105936993

+MTA1chr14

105936971

-
3UTR-3UTRENST00000331320ENST00000406191MTA1chr14

105936993

+MTA1chr14

105936971

-
3UTR-3UTRENST00000331320ENST00000435036MTA1chr14

105936993

+MTA1chr14

105936971

-
3UTR-3UTRENST00000405646ENST00000331320MTA1chr14

105936993

+MTA1chr14

105936971

-
3UTR-3UTRENST00000405646ENST00000405646MTA1chr14

105936993

+MTA1chr14

105936971

-
3UTR-3UTRENST00000405646ENST00000406191MTA1chr14

105936993

+MTA1chr14

105936971

-
3UTR-3UTRENST00000405646ENST00000435036MTA1chr14

105936993

+MTA1chr14

105936971

-
3UTR-3UTRENST00000406191ENST00000331320MTA1chr14

105936993

+MTA1chr14

105936971

-
3UTR-3UTRENST00000406191ENST00000405646MTA1chr14

105936993

+MTA1chr14

105936971

-
3UTR-3UTRENST00000406191ENST00000406191MTA1chr14

105936993

+MTA1chr14

105936971

-
3UTR-3UTRENST00000406191ENST00000435036MTA1chr14

105936993

+MTA1chr14

105936971

-
3UTR-3UTRENST00000435036ENST00000331320MTA1chr14

105936993

+MTA1chr14

105936971

-
3UTR-3UTRENST00000435036ENST00000405646MTA1chr14

105936993

+MTA1chr14

105936971

-
3UTR-3UTRENST00000435036ENST00000406191MTA1chr14

105936993

+MTA1chr14

105936971

-
3UTR-3UTRENST00000435036ENST00000435036MTA1chr14

105936993

+MTA1chr14

105936971

-
5CDS-5UTRENST00000331320ENST00000435036MTA1chr14

105930788

+MTA1chr14

105931052

-
5CDS-5UTRENST00000405646ENST00000435036MTA1chr14

105930788

+MTA1chr14

105931052

-
5CDS-5UTRENST00000406191ENST00000435036MTA1chr14

105930788

+MTA1chr14

105931052

-
5UTR-3CDSENST00000435036ENST00000331320MTA1chr14

105930788

+MTA1chr14

105931052

-
5UTR-3CDSENST00000435036ENST00000405646MTA1chr14

105930788

+MTA1chr14

105931052

-
5UTR-3CDSENST00000435036ENST00000406191MTA1chr14

105930788

+MTA1chr14

105931052

-
5UTR-5UTRENST00000435036ENST00000435036MTA1chr14

105930788

+MTA1chr14

105931052

-
In-frameENST00000331320ENST00000331320MTA1chr14

105930788

+MTA1chr14

105931052

-
In-frameENST00000331320ENST00000405646MTA1chr14

105930788

+MTA1chr14

105931052

-
In-frameENST00000331320ENST00000406191MTA1chr14

105930788

+MTA1chr14

105931052

-
In-frameENST00000405646ENST00000331320MTA1chr14

105930788

+MTA1chr14

105931052

-
In-frameENST00000405646ENST00000405646MTA1chr14

105930788

+MTA1chr14

105931052

-
In-frameENST00000405646ENST00000406191MTA1chr14

105930788

+MTA1chr14

105931052

-
In-frameENST00000406191ENST00000331320MTA1chr14

105930788

+MTA1chr14

105931052

-
In-frameENST00000406191ENST00000405646MTA1chr14

105930788

+MTA1chr14

105931052

-
In-frameENST00000406191ENST00000406191MTA1chr14

105930788

+MTA1chr14

105931052

-
intron-intronENST00000331320ENST00000331320MTA1chr14

105935291

+MTA1chr14

105934539

+
intron-intronENST00000331320ENST00000405646MTA1chr14

105935291

+MTA1chr14

105934539

+
intron-intronENST00000331320ENST00000406191MTA1chr14

105935291

+MTA1chr14

105934539

+
intron-intronENST00000331320ENST00000435036MTA1chr14

105935291

+MTA1chr14

105934539

+
intron-intronENST00000405646ENST00000331320MTA1chr14

105935291

+MTA1chr14

105934539

+
intron-intronENST00000405646ENST00000405646MTA1chr14

105935291

+MTA1chr14

105934539

+
intron-intronENST00000405646ENST00000406191MTA1chr14

105935291

+MTA1chr14

105934539

+
intron-intronENST00000405646ENST00000435036MTA1chr14

105935291

+MTA1chr14

105934539

+
intron-intronENST00000406191ENST00000331320MTA1chr14

105935291

+MTA1chr14

105934539

+
intron-intronENST00000406191ENST00000405646MTA1chr14

105935291

+MTA1chr14

105934539

+
intron-intronENST00000406191ENST00000406191MTA1chr14

105935291

+MTA1chr14

105934539

+
intron-intronENST00000406191ENST00000435036MTA1chr14

105935291

+MTA1chr14

105934539

+
intron-intronENST00000435036ENST00000331320MTA1chr14

105935291

+MTA1chr14

105934539

+
intron-intronENST00000435036ENST00000405646MTA1chr14

105935291

+MTA1chr14

105934539

+
intron-intronENST00000435036ENST00000406191MTA1chr14

105935291

+MTA1chr14

105934539

+
intron-intronENST00000435036ENST00000435036MTA1chr14

105935291

+MTA1chr14

105934539

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MTA1-MTA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MTA1-MTA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:105935291/chr14:105934539)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MTA1

Q13330

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone-deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3. Regulates p53-dependent and -independent DNA repair processes following genotoxic stress. Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair. Plays an important role in tumorigenesis, tumor invasion, and metastasis. Involved in the epigenetic regulation of ESR1 expression in breast cancer in a TFAP2C, IFI16 and HDAC4/5/6-dependent manner. Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles. Positively regulates the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1. Regulates deacetylation of ARNTL/BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression. Isoform Short binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). {ECO:0000250|UniProtKB:Q8K4B0, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17671180, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24413532}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMTA1chr14:105930788chr14:105931052ENST00000331320021697_7050716.0Compositional biasNote=Poly-Pro
TgeneMTA1chr14:105930788chr14:105931052ENST00000405646020697_7050699.0Compositional biasNote=Poly-Pro
TgeneMTA1chr14:105930788chr14:105931052ENST00000331320021165_2760716.0DomainELM2
TgeneMTA1chr14:105930788chr14:105931052ENST000003313200211_1640716.0DomainBAH
TgeneMTA1chr14:105930788chr14:105931052ENST00000331320021283_3350716.0DomainSANT
TgeneMTA1chr14:105930788chr14:105931052ENST00000405646020165_2760699.0DomainELM2
TgeneMTA1chr14:105930788chr14:105931052ENST000004056460201_1640699.0DomainBAH
TgeneMTA1chr14:105930788chr14:105931052ENST00000405646020283_3350699.0DomainSANT
TgeneMTA1chr14:105930788chr14:105931052ENST00000331320021545_5520716.0MotifSH3-binding
TgeneMTA1chr14:105930788chr14:105931052ENST00000331320021696_7050716.0MotifSH3-binding
TgeneMTA1chr14:105930788chr14:105931052ENST00000405646020545_5520699.0MotifSH3-binding
TgeneMTA1chr14:105930788chr14:105931052ENST00000405646020696_7050699.0MotifSH3-binding
TgeneMTA1chr14:105930788chr14:105931052ENST00000331320021393_4200716.0Zinc fingerNote=GATA-type%3B atypical
TgeneMTA1chr14:105930788chr14:105931052ENST00000405646020393_4200699.0Zinc fingerNote=GATA-type%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTA1chr14:105930788chr14:105931052ENST00000331320+121697_7050716.0Compositional biasNote=Poly-Pro
HgeneMTA1chr14:105930788chr14:105931052ENST00000405646+120697_7050699.0Compositional biasNote=Poly-Pro
HgeneMTA1chr14:105930788chr14:105931052ENST00000331320+121165_2760716.0DomainELM2
HgeneMTA1chr14:105930788chr14:105931052ENST00000331320+1211_1640716.0DomainBAH
HgeneMTA1chr14:105930788chr14:105931052ENST00000331320+121283_3350716.0DomainSANT
HgeneMTA1chr14:105930788chr14:105931052ENST00000405646+120165_2760699.0DomainELM2
HgeneMTA1chr14:105930788chr14:105931052ENST00000405646+1201_1640699.0DomainBAH
HgeneMTA1chr14:105930788chr14:105931052ENST00000405646+120283_3350699.0DomainSANT
HgeneMTA1chr14:105930788chr14:105931052ENST00000331320+121545_5520716.0MotifSH3-binding
HgeneMTA1chr14:105930788chr14:105931052ENST00000331320+121696_7050716.0MotifSH3-binding
HgeneMTA1chr14:105930788chr14:105931052ENST00000405646+120545_5520699.0MotifSH3-binding
HgeneMTA1chr14:105930788chr14:105931052ENST00000405646+120696_7050699.0MotifSH3-binding
HgeneMTA1chr14:105930788chr14:105931052ENST00000331320+121393_4200716.0Zinc fingerNote=GATA-type%3B atypical
HgeneMTA1chr14:105930788chr14:105931052ENST00000405646+120393_4200699.0Zinc fingerNote=GATA-type%3B atypical


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Fusion Gene Sequence for MTA1-MTA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MTA1-MTA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MTA1-MTA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MTA1-MTA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource