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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MTAP-EXOC6B (FusionGDB2 ID:55507)

Fusion Gene Summary for MTAP-EXOC6B

Fusion gene summary

Fusion gene information	Fusion gene name: MTAP-EXOC6B
	Fusion gene ID: 55507
		Hgene	Tgene
	Gene symbol	MTAP	EXOC6B
	Gene ID	4507	23233
	Gene name	methylthioadenosine phosphorylase	exocyst complex component 6B
	Synonyms	BDMF\|DMSFH\|DMSMFH\|HEL-249\|LGMBF\|MSAP\|c86fus	SEC15B\|SEC15L2\|SEMDJL3
	Cytomap	9p21.3	2p13.2
	Type of gene	protein-coding	protein-coding
	Description	S-methyl-5'-thioadenosine phosphorylase5'-methylthioadenosine phosphorylaseMTA phosphorylaseMTAPaseMeSAdo phosphorylaseepididymis luminal protein 249epididymis secretory sperm binding protein	exocyst complex component 6BSEC15 homolog BSEC15-like protein 2exocyst complex component Sec15B
	Modification date	20200313	20200313
	UniProtAcc	Q13126	Q9Y2D4
	Ensembl transtripts involved in fusion gene	ENST00000380172, ENST00000460874, ENST00000580900, ENST00000427788,	ENST00000410104, ENST00000490919, ENST00000272427,
Fusion gene scores	* DoF score	13 X 9 X 9=1053	10 X 8 X 6=480
	# samples	17	11
	** MAII score	log2(17/1053*10)=-2.63089878488802 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/480*10)=-2.12553088208386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MTAP [Title/Abstract] AND EXOC6B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MTAP(21854869)-EXOC6B(72606999), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MTAP	GO:0006738	nicotinamide riboside catabolic process	19001417

Fusion gene breakpoints across MTAP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EXOC6B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-97-8176-01A	MTAP	chr9	21854869	-	EXOC6B	chr2	72606999	-

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Fusion Gene ORF analysis for MTAP-EXOC6B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000380172	ENST00000410104	MTAP	chr9	21854869	-	EXOC6B	chr2	72606999	-
5CDS-intron	ENST00000380172	ENST00000490919	MTAP	chr9	21854869	-	EXOC6B	chr2	72606999	-
5CDS-intron	ENST00000460874	ENST00000410104	MTAP	chr9	21854869	-	EXOC6B	chr2	72606999	-
5CDS-intron	ENST00000460874	ENST00000490919	MTAP	chr9	21854869	-	EXOC6B	chr2	72606999	-
5CDS-intron	ENST00000580900	ENST00000410104	MTAP	chr9	21854869	-	EXOC6B	chr2	72606999	-
5CDS-intron	ENST00000580900	ENST00000490919	MTAP	chr9	21854869	-	EXOC6B	chr2	72606999	-
In-frame	ENST00000380172	ENST00000272427	MTAP	chr9	21854869	-	EXOC6B	chr2	72606999	-
In-frame	ENST00000460874	ENST00000272427	MTAP	chr9	21854869	-	EXOC6B	chr2	72606999	-
In-frame	ENST00000580900	ENST00000272427	MTAP	chr9	21854869	-	EXOC6B	chr2	72606999	-
intron-3CDS	ENST00000427788	ENST00000272427	MTAP	chr9	21854869	-	EXOC6B	chr2	72606999	-
intron-intron	ENST00000427788	ENST00000410104	MTAP	chr9	21854869	-	EXOC6B	chr2	72606999	-
intron-intron	ENST00000427788	ENST00000490919	MTAP	chr9	21854869	-	EXOC6B	chr2	72606999	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000580900	MTAP	chr9	21854869	-	ENST00000272427	EXOC6B	chr2	72606999	-	4597	790	100	1245	381
ENST00000380172	MTAP	chr9	21854869	-	ENST00000272427	EXOC6B	chr2	72606999	-	4703	896	206	1351	381
ENST00000460874	MTAP	chr9	21854869	-	ENST00000272427	EXOC6B	chr2	72606999	-	4773	966	174	1421	415

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000580900	ENST00000272427	MTAP	chr9	21854869	-	EXOC6B	chr2	72606999	-	0.004143594	0.99585634
ENST00000380172	ENST00000272427	MTAP	chr9	21854869	-	EXOC6B	chr2	72606999	-	0.00431306	0.99568695
ENST00000460874	ENST00000272427	MTAP	chr9	21854869	-	EXOC6B	chr2	72606999	-	0.001087474	0.9989126

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Fusion Genomic Features for MTAP-EXOC6B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MTAP-EXOC6B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:21854869/chr2:72606999)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MTAP Q13126	EXOC6B Q9Y2D4
FUNCTION: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. {ECO:0000255\|HAMAP-Rule:MF_03155, ECO:0000269\|PubMed:3091600}.	FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MTAP

chr9:21854869

chr2:72606999

ENST00000380172

220_222

230

284.0

Region

Note=Substrate binding

Hgene

MTAP

chr9:21854869

chr2:72606999

ENST00000380172

60_61

230

284.0

Region

Note=Phosphate binding

Hgene

MTAP

chr9:21854869

chr2:72606999

ENST00000380172

93_94

230

284.0

Region

Note=Phosphate binding

Hgene

MTAP

chr9:21854869

chr2:72606999

ENST00000580900

220_222

230

335.0

Region

Note=Substrate binding

Hgene

MTAP

chr9:21854869

chr2:72606999

ENST00000580900

60_61

230

335.0

Region

Note=Phosphate binding

Hgene

MTAP

chr9:21854869

chr2:72606999

ENST00000580900

93_94

230

335.0

Region

Note=Phosphate binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

EXOC6B

chr9:21854869

chr2:72606999

ENST00000272427

50_119

660

812.0

Coiled coil

Ontology_term=ECO:0000255

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Fusion Gene Sequence for MTAP-EXOC6B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>55507_55507_1_MTAP-EXOC6B_MTAP_chr9_21854869_ENST00000380172_EXOC6B_chr2_72606999_ENST00000272427_length(transcript)=4703nt_BP=896nt
GATTTGGGGAAGGGGTGGCGGGGGAGATCCCACACAAGCAGCCAATCCAGCTGTCCCGGGGAGGAAGAGGAGGAGTCAAGGCCCGCCCCT
GGTCTCCGCACTGCTCACTCCCGCGCAGTGAGGTTGGCACAGCCACCGCTCTGTGGCTCGCTTGGTTCCCTTAGTCCCGAGCGCTCGCCC
ACTGCAGATTCCTTTCCCGTGCAGACATGGCCTCTGGCACCACCACCACCGCCGTGAAGATTGGAATAATTGGTGGAACAGGCCTGGATG
ATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAGCCATCTGATGCCTTAATTTTGGGGAAGATAAAAA
ATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATGCCTTCAAAGGTCAACTACCAGGCGAACATCTGGGCTTTGA
AGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAGGAGATTCAGCCCGGCGATATTGTCATTATTGATC
AGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGTCATTCTTGTGCCAGAGGAGTGTGCCATATTCCAATGGCTG
AGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGACTCCGGTGCCACTCAAAGGGGACAATGGTCACAA
TCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACCTGGGGGGCGGATGTTATCAACATGACCACAGTTCCAGAGG
TGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGATTATGACTGCTGGAAGGAGCACGAGGAAGCAGGAA
AGGTGGCCCAGACAGCGTGTATGTCAGCTTGCAAGCATTTAGCCACATCCTTGATGCAACTTTTGTTGGAAGCTGAAGTGCGGCAGCTCA
CCTTGGGAGCATTACAGCAGTTCAACTTGGACGTCAGAGAATGTGAACAGTTTGCCAGATCCGGCCCGGTGCCTGGGTTCCAGGAGGACA
CGCTGCAGTTGGCCTTCATCGACTTGAGACAACTTTTGGATCTTTTCATCCAGTGGGATTGGTCAACCTACCTTGCTGACTATGGTCAGC
CCAACTGCAAGTACCTCCGGGTAAACCCAGTGACTGCTCTGACCCTGCTTGAGAAGATGAAGGATACTAGCCGCAAGAACAACATGTTTG
CACAGTTTCGGAAAAATGAGCGAGACAAGCAGAAACTCATTGACACCGTGGCCAAGCAGCTCCGAGGACTCATCAGCAGCCACCACTCAT
GAAGGGTGACCCCGGACCCACAGAGGCGACCTGCTGCAGCCTCTGTGTCAGTCTGGGGTCCAGCCCCAGCTGACCCTGCATTTGTGCATT
CTTCTTCAAAGAGAGCATATGTATTTTTTTATTAACCCCTGTGCAGTATTCACATAACATTTCCCTATAGTAAAAGAGGCACAAGAATAA
GCAAGTACATGAGATGTTGCTAGGCTGGGACTCAGGGGAAGTTATTACTACACTATCTGTGTTATCTTAGAGATGGTGGTATCATCAATT
CCACAGTGATGAACCACCTTTCATCCATGGCTCTAAAGCTTAGGTCTGGGGCTTAGGAACCATAAAAAGTGGGTATCTGGCGCTGGGAGG
TAGAGTGAGTAAGCAAAAGGATACTAAAATATGTCCTGTTCACTCTTGGATGCCCATTCACCACATAGATGAGGCTGATTCTTCTCAATA
CAAGGAAAGGGCATGGCAAACATTACTATTTAGTACACTAAGGGCAGCTCTGGAGGGTCATCTCCTCAGTCTGCTGACTTTCACTGGCTT
GTGAACAAGCATGGCATATGGCAAGATGACAGCTTCATTCCAATCCCCCAAGAATGGCGGTTTCTTTAGCCTGATCTAACCCCAGGCTTT
TATTGCAATTTTTTCTAGGGCAGGATACAGCTAAGTAGACAGCAGTAATAATTGGATCCCATGTTTAACTGCATATTGCCCCAGCTCTAG
GAGTGTTGAGTCTCAACTCGAAGAGTTTTTCTGGATCTTGAAAGCCAGTTTTCATGGAATCAGAGACCCAATCCCTTCCCTGTTCATCTC
ATTTCCTTCACTTACAGTCAGAGCACTTGGTTCAGGACATAAATCAACAGTTACTTCCATAGGCCTTCACAGGGCGTTTCAGACTTAGCC
TCCTCCAGTAATGCCATTGAAATAGTTCAGATTTCGGAAGCCTAAAAATGGCCTTTACCTTACCCTTAGGTGTAACCTGAGGATTAGTTG
GGATTGTTCCTTTATGTTTTAAAACCAGCTTTTTGGTTATCATCTTTAAGGAAATGTCACCAGCTCTGCACTGTGGGGGCAGCCATGCCT
GGACTGGATGCCTCTAGGGATGGAGACATTGTTACCATAAAGTCGACAGAGCCAACCATGGCTTGTGGCTTGTTGCCTCTGGCCCAACTG
TCCTTCACTAAATAATATCCTAGATATTATTTTGTTGCTCAAGCCCAAGGTTCCCACCCTCTTTTGAGATCCCCAAAGCCATCTTTGGCC
TTGTCTAAGAAAGATTGCCTATAATCCTGTCCTCCAAACTCTAAAGCCTGGAGCAGCTTAGCGTGGAGGCTGCACTCATTGACCCAGATG
GACTCCTGAGACTTAACGCAAGGGCTTTGCTATGAGGTCAGTCGGGGGAAACTGTACTTTAAGACACTTCAGAAAGATGCTACTGGCTAG
TAGCAGAAAGATGGCTAGTGGCAAGAGTATAATTGTGCATCACCAAACAATGACAAATAAGCCACACAGGCATTTCCAGCTTGGATTGAT
GGGAGGAGAGACTCATCAAACAGAATTCTTCACTACCTTTGTCAGCTACTGAGTTGCTTCTGGGGAGGGAAGTACTTCCTTGCCCCTCCC
CAACCCCCCTACCTCACCATATCCTATCATATCTTGATAGTCATGGGGAAGAGGATGTGCACACAGACATACAAATTTCCTCAAAGCTGG
AGAGACCAGGCTACATGTGAGCTCATAGATGCTGCTGAGGCTCATCCTGAGGGCTGGATGGTTGGCCAGGGTTTCAGAATGAGGGTAAGG
GATGAGCACTGCCACCCAGAACTTGATAAGCCAAGAGAAGGCAGGAGCCAAAATGGCATCGCCAAGCTCTCATCTTTGTTGAAACAAGTG
AGAAACGATTATATTAATCTGAAGTTCTATTGCTTGAGAAGAGTTCAAAACACTTCTCTTTGCTAGTACCCAGTTTGCAGCAAGATCTCT
TCAGCTTTAAGTGCTGAGAGACTTTGAAGTGGAAATGGAGAGATGTGTAAGCATGGCACAGTGTTTGTCTTTTTAGAGGATCATCATTGC
TGGTCTGGTCTCAAACCTCTGCCTTGGAAGAACTGTGCTATACAGGAAAAAGTGAACAAGGTGGAGGAATAGGGGTTATTCTGCACAGAA
GTCCCATGAAAGGAAAAGCTTATTCAAGCTCAAGACATAAAGATGGACCCTTTGATATATCTTCTCTCCATTCTTAGTCTGCCTTCACCT
TATCTAACAAAAAACAACATGCAGCTACTGAGTTGTATGTAGAGACATACTCTTGGTGGGCCAGGGAAGGTAAAAACAGGGACCAGCAAT
GTCAAGTTTTTGAACTAGAAAAGTGGGATGTTTTTAGTTTTGTCTATAACCTGTAGCTGGGCCAACCCTTGAGAGGACTTGTGCAAAGCA
TGTGTGCCCAGACCCATCAGACTCCTCAGATATGGCCTCAAATACCTAGAGATGTAGAAGTACCGTGGAGGGCCTCAATAAGAGGGCAAG
CACACAGATGGCTAGAAGCCTGTATGGCTTCTGGTCAGGATGAACCCTTGGCCAAGTTCTTGAGGAAACCAGGTCTATATTCCTGAAGGG
ACAGTTCAGTTTGGGACTCTATTAGGTTTCAGTAGTAATATAGGCTGCTTGCATCATTTTAACATTCATAGGGAAAATCTCTTTGAGCAG
GCTATAAATGAAGCTGTTGCAGGTAGGGAAGAACAGGACCTGAAAATGGGAACCAGGAAGTGAGATCCTGTTGGCAAAGGGAATGTAGAG
CTTCCAGGGTGCATTGCCCACTGTTCTCATTGCATACCAGTCCTCCAAGTCAGTCTAGCCTTACTGTACACTTGACAAGTGCTTACTCAG
CAAGTCCCAGACCCACGGCCTTTTATCTCCCAAGACTGGCTTTGGCCATGACCTTCCTCATCAGGCCTCTGAGCACACTCTCTAGGAACT
GCTGCAGAAATTCCCCTACCTTAGCCTCCCTTCTCCCAGGACTCCTCTCTTGACTGCAATTGCCTCTTCTTCTTCTTCTTCTTCTTCCTT
TTTGTTTTTTTTTTTTTTGCCTGCATTCACAATTACTTTTCACAAAGGTGTTGGAAATGGCATTTTTATTTTACACAGATAGTTGCACAT
ATATAGAGAAAATTAGGAAAGTCCATTTTTAACTCTAAAGGGAACTTTTTTCTCTAAAACTTACTTGTAAAGCTACTGATACAGATGGGC
CGCATGGTTAGGGGAAAGCTCCTCTGTGAAAAGAGCATGTTTATTCCTCTTGTACATTTTCCTCTTTTAACTGCTATTAAACAAGAAAGC

>55507_55507_1_MTAP-EXOC6B_MTAP_chr9_21854869_ENST00000380172_EXOC6B_chr2_72606999_ENST00000272427_length(amino acids)=381AA_BP=230
MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVI
VTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSR
AESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAGKVAQTACMSACKHLATSLMQLLLEAEVRQLTLGALQQFN
LDVRECEQFARSGPVPGFQEDTLQLAFIDLRQLLDLFIQWDWSTYLADYGQPNCKYLRVNPVTALTLLEKMKDTSRKNNMFAQFRKNERD

--------------------------------------------------------------
>55507_55507_2_MTAP-EXOC6B_MTAP_chr9_21854869_ENST00000460874_EXOC6B_chr2_72606999_ENST00000272427_length(transcript)=4773nt_BP=966nt
ACTGCTCACTCCCGCGCAGTGAGGTTGGCACAGCCACCGCTCTGTGGCTCGCTTGGTTCCCTTAGTCCCGAGCGCTCGCCCACTGCAGAT
TCCTTTCCCGTGCAGACATGGCCTCTGGCACCACCACCACCGCCGTGAAGGTGAGATGAGCCCTCCCAGCCGCAGCGGTTCGCCCTGCCG
GATGCCTTCTCGCCCCCGCGCCGGGGGACCGCGCCTCCGGGGGCCATGCGCCCGGCCCGTGCGTCCCTTGCCGCCGCGGGGAGGGACTGG
GGCGCGGCACTCGGGACTCACTTGCCGCGCGAGGAGAGGATTGGAATAATTGGTGGAACAGGCCTGGATGATCCAGAAATTTTAGAAGGA
AGAACTGAAAAATATGTGGATACTCCATTTGGCAAGCCATCTGATGCCTTAATTTTGGGGAAGATAAAAAATGTTGATTGCGTCCTCCTT
GCAAGGCATGGAAGGCAGCACACCATCATGCCTTCAAAGGTCAACTACCAGGCGAACATCTGGGCTTTGAAGGAAGAGGGCTGTACACAT
GTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAGGAGATTCAGCCCGGCGATATTGTCATTATTGATCAGTTCATTGACAGGACCACT
ATGAGACCTCAGTCCTTCTATGATGGAAGTCATTCTTGTGCCAGAGGAGTGTGCCATATTCCAATGGCTGAGCCGTTTTGCCCCAAAACG
AGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGACTCCGGTGCCACTCAAAGGGGACAATGGTCACAATCGAGGGACCTCGTTTTAGC
TCCCGGGCAGAAAGCTTCATGTTCCGCACCTGGGGGGCGGATGTTATCAACATGACCACAGTTCCAGAGGTGGTTCTTGCTAAGGAGGCT
GGAATTTGTTACGCAAGTATCGCCATGGCGACAGATTATGACTGCTGGAAGGAGCACGAGGAAGCAGGAAAGGTGGCCCAGACAGCGTGT
ATGTCAGCTTGCAAGCATTTAGCCACATCCTTGATGCAACTTTTGTTGGAAGCTGAAGTGCGGCAGCTCACCTTGGGAGCATTACAGCAG
TTCAACTTGGACGTCAGAGAATGTGAACAGTTTGCCAGATCCGGCCCGGTGCCTGGGTTCCAGGAGGACACGCTGCAGTTGGCCTTCATC
GACTTGAGACAACTTTTGGATCTTTTCATCCAGTGGGATTGGTCAACCTACCTTGCTGACTATGGTCAGCCCAACTGCAAGTACCTCCGG
GTAAACCCAGTGACTGCTCTGACCCTGCTTGAGAAGATGAAGGATACTAGCCGCAAGAACAACATGTTTGCACAGTTTCGGAAAAATGAG
CGAGACAAGCAGAAACTCATTGACACCGTGGCCAAGCAGCTCCGAGGACTCATCAGCAGCCACCACTCATGAAGGGTGACCCCGGACCCA
CAGAGGCGACCTGCTGCAGCCTCTGTGTCAGTCTGGGGTCCAGCCCCAGCTGACCCTGCATTTGTGCATTCTTCTTCAAAGAGAGCATAT
GTATTTTTTTATTAACCCCTGTGCAGTATTCACATAACATTTCCCTATAGTAAAAGAGGCACAAGAATAAGCAAGTACATGAGATGTTGC
TAGGCTGGGACTCAGGGGAAGTTATTACTACACTATCTGTGTTATCTTAGAGATGGTGGTATCATCAATTCCACAGTGATGAACCACCTT
TCATCCATGGCTCTAAAGCTTAGGTCTGGGGCTTAGGAACCATAAAAAGTGGGTATCTGGCGCTGGGAGGTAGAGTGAGTAAGCAAAAGG
ATACTAAAATATGTCCTGTTCACTCTTGGATGCCCATTCACCACATAGATGAGGCTGATTCTTCTCAATACAAGGAAAGGGCATGGCAAA
CATTACTATTTAGTACACTAAGGGCAGCTCTGGAGGGTCATCTCCTCAGTCTGCTGACTTTCACTGGCTTGTGAACAAGCATGGCATATG
GCAAGATGACAGCTTCATTCCAATCCCCCAAGAATGGCGGTTTCTTTAGCCTGATCTAACCCCAGGCTTTTATTGCAATTTTTTCTAGGG
CAGGATACAGCTAAGTAGACAGCAGTAATAATTGGATCCCATGTTTAACTGCATATTGCCCCAGCTCTAGGAGTGTTGAGTCTCAACTCG
AAGAGTTTTTCTGGATCTTGAAAGCCAGTTTTCATGGAATCAGAGACCCAATCCCTTCCCTGTTCATCTCATTTCCTTCACTTACAGTCA
GAGCACTTGGTTCAGGACATAAATCAACAGTTACTTCCATAGGCCTTCACAGGGCGTTTCAGACTTAGCCTCCTCCAGTAATGCCATTGA
AATAGTTCAGATTTCGGAAGCCTAAAAATGGCCTTTACCTTACCCTTAGGTGTAACCTGAGGATTAGTTGGGATTGTTCCTTTATGTTTT
AAAACCAGCTTTTTGGTTATCATCTTTAAGGAAATGTCACCAGCTCTGCACTGTGGGGGCAGCCATGCCTGGACTGGATGCCTCTAGGGA
TGGAGACATTGTTACCATAAAGTCGACAGAGCCAACCATGGCTTGTGGCTTGTTGCCTCTGGCCCAACTGTCCTTCACTAAATAATATCC
TAGATATTATTTTGTTGCTCAAGCCCAAGGTTCCCACCCTCTTTTGAGATCCCCAAAGCCATCTTTGGCCTTGTCTAAGAAAGATTGCCT
ATAATCCTGTCCTCCAAACTCTAAAGCCTGGAGCAGCTTAGCGTGGAGGCTGCACTCATTGACCCAGATGGACTCCTGAGACTTAACGCA
AGGGCTTTGCTATGAGGTCAGTCGGGGGAAACTGTACTTTAAGACACTTCAGAAAGATGCTACTGGCTAGTAGCAGAAAGATGGCTAGTG
GCAAGAGTATAATTGTGCATCACCAAACAATGACAAATAAGCCACACAGGCATTTCCAGCTTGGATTGATGGGAGGAGAGACTCATCAAA
CAGAATTCTTCACTACCTTTGTCAGCTACTGAGTTGCTTCTGGGGAGGGAAGTACTTCCTTGCCCCTCCCCAACCCCCCTACCTCACCAT
ATCCTATCATATCTTGATAGTCATGGGGAAGAGGATGTGCACACAGACATACAAATTTCCTCAAAGCTGGAGAGACCAGGCTACATGTGA
GCTCATAGATGCTGCTGAGGCTCATCCTGAGGGCTGGATGGTTGGCCAGGGTTTCAGAATGAGGGTAAGGGATGAGCACTGCCACCCAGA
ACTTGATAAGCCAAGAGAAGGCAGGAGCCAAAATGGCATCGCCAAGCTCTCATCTTTGTTGAAACAAGTGAGAAACGATTATATTAATCT
GAAGTTCTATTGCTTGAGAAGAGTTCAAAACACTTCTCTTTGCTAGTACCCAGTTTGCAGCAAGATCTCTTCAGCTTTAAGTGCTGAGAG
ACTTTGAAGTGGAAATGGAGAGATGTGTAAGCATGGCACAGTGTTTGTCTTTTTAGAGGATCATCATTGCTGGTCTGGTCTCAAACCTCT
GCCTTGGAAGAACTGTGCTATACAGGAAAAAGTGAACAAGGTGGAGGAATAGGGGTTATTCTGCACAGAAGTCCCATGAAAGGAAAAGCT
TATTCAAGCTCAAGACATAAAGATGGACCCTTTGATATATCTTCTCTCCATTCTTAGTCTGCCTTCACCTTATCTAACAAAAAACAACAT
GCAGCTACTGAGTTGTATGTAGAGACATACTCTTGGTGGGCCAGGGAAGGTAAAAACAGGGACCAGCAATGTCAAGTTTTTGAACTAGAA
AAGTGGGATGTTTTTAGTTTTGTCTATAACCTGTAGCTGGGCCAACCCTTGAGAGGACTTGTGCAAAGCATGTGTGCCCAGACCCATCAG
ACTCCTCAGATATGGCCTCAAATACCTAGAGATGTAGAAGTACCGTGGAGGGCCTCAATAAGAGGGCAAGCACACAGATGGCTAGAAGCC
TGTATGGCTTCTGGTCAGGATGAACCCTTGGCCAAGTTCTTGAGGAAACCAGGTCTATATTCCTGAAGGGACAGTTCAGTTTGGGACTCT
ATTAGGTTTCAGTAGTAATATAGGCTGCTTGCATCATTTTAACATTCATAGGGAAAATCTCTTTGAGCAGGCTATAAATGAAGCTGTTGC
AGGTAGGGAAGAACAGGACCTGAAAATGGGAACCAGGAAGTGAGATCCTGTTGGCAAAGGGAATGTAGAGCTTCCAGGGTGCATTGCCCA
CTGTTCTCATTGCATACCAGTCCTCCAAGTCAGTCTAGCCTTACTGTACACTTGACAAGTGCTTACTCAGCAAGTCCCAGACCCACGGCC
TTTTATCTCCCAAGACTGGCTTTGGCCATGACCTTCCTCATCAGGCCTCTGAGCACACTCTCTAGGAACTGCTGCAGAAATTCCCCTACC
TTAGCCTCCCTTCTCCCAGGACTCCTCTCTTGACTGCAATTGCCTCTTCTTCTTCTTCTTCTTCTTCCTTTTTGTTTTTTTTTTTTTTGC
CTGCATTCACAATTACTTTTCACAAAGGTGTTGGAAATGGCATTTTTATTTTACACAGATAGTTGCACATATATAGAGAAAATTAGGAAA
GTCCATTTTTAACTCTAAAGGGAACTTTTTTCTCTAAAACTTACTTGTAAAGCTACTGATACAGATGGGCCGCATGGTTAGGGGAAAGCT
CCTCTGTGAAAAGAGCATGTTTATTCCTCTTGTACATTTTCCTCTTTTAACTGCTATTAAACAAGAAAGCCTACATACCTGTTTCAAAAG

>55507_55507_2_MTAP-EXOC6B_MTAP_chr9_21854869_ENST00000460874_EXOC6B_chr2_72606999_ENST00000272427_length(amino acids)=415AA_BP=264
MPDAFSPPRRGTAPPGAMRPARASLAAAGRDWGAALGTHLPREERIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCV
LLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCP
KTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAGKVAQT
ACMSACKHLATSLMQLLLEAEVRQLTLGALQQFNLDVRECEQFARSGPVPGFQEDTLQLAFIDLRQLLDLFIQWDWSTYLADYGQPNCKY

--------------------------------------------------------------
>55507_55507_3_MTAP-EXOC6B_MTAP_chr9_21854869_ENST00000580900_EXOC6B_chr2_72606999_ENST00000272427_length(transcript)=4597nt_BP=790nt
ACTCCCGCGCAGTGAGGTTGGCACAGCCACCGCTCTGTGGCTCGCTTGGTTCCCTTAGTCCCGAGCGCTCGCCCACTGCAGATTCCTTTC
CCGTGCAGACATGGCCTCTGGCACCACCACCACCGCCGTGAAGATTGGAATAATTGGTGGAACAGGCCTGGATGATCCAGAAATTTTAGA
AGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAGCCATCTGATGCCTTAATTTTGGGGAAGATAAAAAATGTTGATTGCGTCCT
CCTTGCAAGGCATGGAAGGCAGCACACCATCATGCCTTCAAAGGTCAACTACCAGGCGAACATCTGGGCTTTGAAGGAAGAGGGCTGTAC
ACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAGGAGATTCAGCCCGGCGATATTGTCATTATTGATCAGTTCATTGACAGGAC
CACTATGAGACCTCAGTCCTTCTATGATGGAAGTCATTCTTGTGCCAGAGGAGTGTGCCATATTCCAATGGCTGAGCCGTTTTGCCCCAA
AACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGACTCCGGTGCCACTCAAAGGGGACAATGGTCACAATCGAGGGACCTCGTTT
TAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACCTGGGGGGCGGATGTTATCAACATGACCACAGTTCCAGAGGTGGTTCTTGCTAAGGA
GGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGATTATGACTGCTGGAAGGAGCACGAGGAAGCAGGAAAGGTGGCCCAGACAGC
GTGTATGTCAGCTTGCAAGCATTTAGCCACATCCTTGATGCAACTTTTGTTGGAAGCTGAAGTGCGGCAGCTCACCTTGGGAGCATTACA
GCAGTTCAACTTGGACGTCAGAGAATGTGAACAGTTTGCCAGATCCGGCCCGGTGCCTGGGTTCCAGGAGGACACGCTGCAGTTGGCCTT
CATCGACTTGAGACAACTTTTGGATCTTTTCATCCAGTGGGATTGGTCAACCTACCTTGCTGACTATGGTCAGCCCAACTGCAAGTACCT
CCGGGTAAACCCAGTGACTGCTCTGACCCTGCTTGAGAAGATGAAGGATACTAGCCGCAAGAACAACATGTTTGCACAGTTTCGGAAAAA
TGAGCGAGACAAGCAGAAACTCATTGACACCGTGGCCAAGCAGCTCCGAGGACTCATCAGCAGCCACCACTCATGAAGGGTGACCCCGGA
CCCACAGAGGCGACCTGCTGCAGCCTCTGTGTCAGTCTGGGGTCCAGCCCCAGCTGACCCTGCATTTGTGCATTCTTCTTCAAAGAGAGC
ATATGTATTTTTTTATTAACCCCTGTGCAGTATTCACATAACATTTCCCTATAGTAAAAGAGGCACAAGAATAAGCAAGTACATGAGATG
TTGCTAGGCTGGGACTCAGGGGAAGTTATTACTACACTATCTGTGTTATCTTAGAGATGGTGGTATCATCAATTCCACAGTGATGAACCA
CCTTTCATCCATGGCTCTAAAGCTTAGGTCTGGGGCTTAGGAACCATAAAAAGTGGGTATCTGGCGCTGGGAGGTAGAGTGAGTAAGCAA
AAGGATACTAAAATATGTCCTGTTCACTCTTGGATGCCCATTCACCACATAGATGAGGCTGATTCTTCTCAATACAAGGAAAGGGCATGG
CAAACATTACTATTTAGTACACTAAGGGCAGCTCTGGAGGGTCATCTCCTCAGTCTGCTGACTTTCACTGGCTTGTGAACAAGCATGGCA
TATGGCAAGATGACAGCTTCATTCCAATCCCCCAAGAATGGCGGTTTCTTTAGCCTGATCTAACCCCAGGCTTTTATTGCAATTTTTTCT
AGGGCAGGATACAGCTAAGTAGACAGCAGTAATAATTGGATCCCATGTTTAACTGCATATTGCCCCAGCTCTAGGAGTGTTGAGTCTCAA
CTCGAAGAGTTTTTCTGGATCTTGAAAGCCAGTTTTCATGGAATCAGAGACCCAATCCCTTCCCTGTTCATCTCATTTCCTTCACTTACA
GTCAGAGCACTTGGTTCAGGACATAAATCAACAGTTACTTCCATAGGCCTTCACAGGGCGTTTCAGACTTAGCCTCCTCCAGTAATGCCA
TTGAAATAGTTCAGATTTCGGAAGCCTAAAAATGGCCTTTACCTTACCCTTAGGTGTAACCTGAGGATTAGTTGGGATTGTTCCTTTATG
TTTTAAAACCAGCTTTTTGGTTATCATCTTTAAGGAAATGTCACCAGCTCTGCACTGTGGGGGCAGCCATGCCTGGACTGGATGCCTCTA
GGGATGGAGACATTGTTACCATAAAGTCGACAGAGCCAACCATGGCTTGTGGCTTGTTGCCTCTGGCCCAACTGTCCTTCACTAAATAAT
ATCCTAGATATTATTTTGTTGCTCAAGCCCAAGGTTCCCACCCTCTTTTGAGATCCCCAAAGCCATCTTTGGCCTTGTCTAAGAAAGATT
GCCTATAATCCTGTCCTCCAAACTCTAAAGCCTGGAGCAGCTTAGCGTGGAGGCTGCACTCATTGACCCAGATGGACTCCTGAGACTTAA
CGCAAGGGCTTTGCTATGAGGTCAGTCGGGGGAAACTGTACTTTAAGACACTTCAGAAAGATGCTACTGGCTAGTAGCAGAAAGATGGCT
AGTGGCAAGAGTATAATTGTGCATCACCAAACAATGACAAATAAGCCACACAGGCATTTCCAGCTTGGATTGATGGGAGGAGAGACTCAT
CAAACAGAATTCTTCACTACCTTTGTCAGCTACTGAGTTGCTTCTGGGGAGGGAAGTACTTCCTTGCCCCTCCCCAACCCCCCTACCTCA
CCATATCCTATCATATCTTGATAGTCATGGGGAAGAGGATGTGCACACAGACATACAAATTTCCTCAAAGCTGGAGAGACCAGGCTACAT
GTGAGCTCATAGATGCTGCTGAGGCTCATCCTGAGGGCTGGATGGTTGGCCAGGGTTTCAGAATGAGGGTAAGGGATGAGCACTGCCACC
CAGAACTTGATAAGCCAAGAGAAGGCAGGAGCCAAAATGGCATCGCCAAGCTCTCATCTTTGTTGAAACAAGTGAGAAACGATTATATTA
ATCTGAAGTTCTATTGCTTGAGAAGAGTTCAAAACACTTCTCTTTGCTAGTACCCAGTTTGCAGCAAGATCTCTTCAGCTTTAAGTGCTG
AGAGACTTTGAAGTGGAAATGGAGAGATGTGTAAGCATGGCACAGTGTTTGTCTTTTTAGAGGATCATCATTGCTGGTCTGGTCTCAAAC
CTCTGCCTTGGAAGAACTGTGCTATACAGGAAAAAGTGAACAAGGTGGAGGAATAGGGGTTATTCTGCACAGAAGTCCCATGAAAGGAAA
AGCTTATTCAAGCTCAAGACATAAAGATGGACCCTTTGATATATCTTCTCTCCATTCTTAGTCTGCCTTCACCTTATCTAACAAAAAACA
ACATGCAGCTACTGAGTTGTATGTAGAGACATACTCTTGGTGGGCCAGGGAAGGTAAAAACAGGGACCAGCAATGTCAAGTTTTTGAACT
AGAAAAGTGGGATGTTTTTAGTTTTGTCTATAACCTGTAGCTGGGCCAACCCTTGAGAGGACTTGTGCAAAGCATGTGTGCCCAGACCCA
TCAGACTCCTCAGATATGGCCTCAAATACCTAGAGATGTAGAAGTACCGTGGAGGGCCTCAATAAGAGGGCAAGCACACAGATGGCTAGA
AGCCTGTATGGCTTCTGGTCAGGATGAACCCTTGGCCAAGTTCTTGAGGAAACCAGGTCTATATTCCTGAAGGGACAGTTCAGTTTGGGA
CTCTATTAGGTTTCAGTAGTAATATAGGCTGCTTGCATCATTTTAACATTCATAGGGAAAATCTCTTTGAGCAGGCTATAAATGAAGCTG
TTGCAGGTAGGGAAGAACAGGACCTGAAAATGGGAACCAGGAAGTGAGATCCTGTTGGCAAAGGGAATGTAGAGCTTCCAGGGTGCATTG
CCCACTGTTCTCATTGCATACCAGTCCTCCAAGTCAGTCTAGCCTTACTGTACACTTGACAAGTGCTTACTCAGCAAGTCCCAGACCCAC
GGCCTTTTATCTCCCAAGACTGGCTTTGGCCATGACCTTCCTCATCAGGCCTCTGAGCACACTCTCTAGGAACTGCTGCAGAAATTCCCC
TACCTTAGCCTCCCTTCTCCCAGGACTCCTCTCTTGACTGCAATTGCCTCTTCTTCTTCTTCTTCTTCTTCCTTTTTGTTTTTTTTTTTT
TTGCCTGCATTCACAATTACTTTTCACAAAGGTGTTGGAAATGGCATTTTTATTTTACACAGATAGTTGCACATATATAGAGAAAATTAG
GAAAGTCCATTTTTAACTCTAAAGGGAACTTTTTTCTCTAAAACTTACTTGTAAAGCTACTGATACAGATGGGCCGCATGGTTAGGGGAA
AGCTCCTCTGTGAAAAGAGCATGTTTATTCCTCTTGTACATTTTCCTCTTTTAACTGCTATTAAACAAGAAAGCCTACATACCTGTTTCA

>55507_55507_3_MTAP-EXOC6B_MTAP_chr9_21854869_ENST00000580900_EXOC6B_chr2_72606999_ENST00000272427_length(amino acids)=381AA_BP=230
MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVI
VTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSR
AESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAGKVAQTACMSACKHLATSLMQLLLEAEVRQLTLGALQQFN
LDVRECEQFARSGPVPGFQEDTLQLAFIDLRQLLDLFIQWDWSTYLADYGQPNCKYLRVNPVTALTLLEKMKDTSRKNNMFAQFRKNERD

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MTAP-EXOC6B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MTAP-EXOC6B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MTAP-EXOC6B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source