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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MTDH-CALB1 (FusionGDB2 ID:55597)

Fusion Gene Summary for MTDH-CALB1

Fusion gene summary

Fusion gene information	Fusion gene name: MTDH-CALB1
	Fusion gene ID: 55597
		Hgene	Tgene
	Gene symbol	MTDH	CALB1
	Gene ID	92140	793
	Gene name	metadherin	calbindin 1
	Synonyms	3D3\|AEG-1\|AEG1\|LYRIC\|LYRIC/3D3	CALB\|D-28K
	Cytomap	8q22.1	8q21.3
	Type of gene	protein-coding	protein-coding
	Description	protein LYRIC3D3/LYRICastrocyte elevated gene 1astrocyte elevated gene-1 proteinlysine-rich CEACAM1 co-isolated proteinmetastasis adhesion protein	calbindinRTVL-H proteincalbindin 1, (28kD)calbindin 1, 28kDacalbindin 27calbindin D28vitamin D-dependent calcium-binding protein, avian-type
	Modification date	20200313	20200313
	UniProtAcc	Q86UE4	.
	Ensembl transtripts involved in fusion gene	ENST00000336273, ENST00000519934,	ENST00000518457, ENST00000265431,
Fusion gene scores	* DoF score	15 X 10 X 9=1350	3 X 3 X 3=27
	# samples	20	3
	** MAII score	log2(20/1350*10)=-2.75488750216347 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: MTDH [Title/Abstract] AND CALB1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MTDH(98735263)-CALB1(91094330), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MTDH	GO:0000122	negative regulation of transcription by RNA polymerase II	15927426
Hgene	MTDH	GO:0010508	positive regulation of autophagy	21127263
Hgene	MTDH	GO:0043066	negative regulation of apoptotic process	17704808
Hgene	MTDH	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	16452207\|18316612
Hgene	MTDH	GO:0045766	positive regulation of angiogenesis	19940250
Hgene	MTDH	GO:0051092	positive regulation of NF-kappaB transcription factor activity	16452207\|18316612
Hgene	MTDH	GO:0051897	positive regulation of protein kinase B signaling	17704808

Fusion gene breakpoints across MTDH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CALB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A8-A07C-01A	MTDH	chr8	98735263	+	CALB1	chr8	91094330	-

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Fusion Gene ORF analysis for MTDH-CALB1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000336273	ENST00000518457	MTDH	chr8	98735263	+	CALB1	chr8	91094330	-
5CDS-intron	ENST00000519934	ENST00000518457	MTDH	chr8	98735263	+	CALB1	chr8	91094330	-
In-frame	ENST00000336273	ENST00000265431	MTDH	chr8	98735263	+	CALB1	chr8	91094330	-
In-frame	ENST00000519934	ENST00000265431	MTDH	chr8	98735263	+	CALB1	chr8	91094330	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000336273

MTDH

chr8

98735263

ENST00000265431

CALB1

chr8

91094330

4278

2006

301

2712

803

ENST00000519934

MTDH

chr8

98735263

ENST00000265431

CALB1

chr8

91094330

3812

1540

2246

741

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000336273	ENST00000265431	MTDH	chr8	98735263	+	CALB1	chr8	91094330	-	0.000985832	0.99901414
ENST00000519934	ENST00000265431	MTDH	chr8	98735263	+	CALB1	chr8	91094330	-	0.000345773	0.9996542

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Fusion Genomic Features for MTDH-CALB1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MTDH-CALB1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:98735263/chr8:91094330)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MTDH Q86UE4	.
FUNCTION: Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269\|PubMed:15927426, ECO:0000269\|PubMed:16452207, ECO:0000269\|PubMed:18316612, ECO:0000269\|PubMed:19111877}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MTDH

chr8:98735263

chr8:91094330

ENST00000336273

441_451

559

583.0

Compositional bias

Note=Poly-Lys

Hgene

MTDH

chr8:98735263

chr8:91094330

ENST00000336273

59_67

559

583.0

Compositional bias

Note=Poly-Leu

Hgene

MTDH

chr8:98735263

chr8:91094330

ENST00000336273

1_71

559

583.0

Region

Note=Activation of NF-kappa-B

Hgene

MTDH

chr8:98735263

chr8:91094330

ENST00000336273

381_443

559

583.0

Region

Lung-homing for mammary tumors

Hgene

MTDH

chr8:98735263

chr8:91094330

ENST00000336273

1_48

559

583.0

Topological domain

Lumenal

Hgene

MTDH

chr8:98735263

chr8:91094330

ENST00000336273

49_69

559

583.0

Transmembrane

Helical

Tgene

CALB1

chr8:98735263

chr8:91094330

ENST00000265431

111_122

262.0

Calcium binding

Tgene

CALB1

chr8:98735263

chr8:91094330

ENST00000265431

155_166

262.0

Calcium binding

Tgene

CALB1

chr8:98735263

chr8:91094330

ENST00000265431

199_210

262.0

Calcium binding

Tgene

CALB1

chr8:98735263

chr8:91094330

ENST00000265431

24_35

262.0

Calcium binding

Tgene

CALB1

chr8:98735263

chr8:91094330

ENST00000265431

142_177

262.0

Domain

EF-hand 4

Tgene

CALB1

chr8:98735263

chr8:91094330

ENST00000265431

186_221

262.0

Domain

EF-hand 5

Tgene

CALB1

chr8:98735263

chr8:91094330

ENST00000265431

53_88

262.0

Domain

EF-hand 2

Tgene

CALB1

chr8:98735263

chr8:91094330

ENST00000265431

98_133

262.0

Domain

EF-hand 3

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MTDH

chr8:98735263

chr8:91094330

ENST00000336273

573_577

559

583.0

Compositional bias

Note=Poly-Lys

Hgene

MTDH

chr8:98735263

chr8:91094330

ENST00000336273

70_582

559

583.0

Topological domain

Cytoplasmic

Tgene

CALB1

chr8:98735263

chr8:91094330

ENST00000265431

11_46

262.0

Domain

EF-hand 1

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Fusion Gene Sequence for MTDH-CALB1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>55597_55597_1_MTDH-CALB1_MTDH_chr8_98735263_ENST00000336273_CALB1_chr8_91094330_ENST00000265431_length(transcript)=4278nt_BP=2006nt
GGCCCAAGCCGCCATTGTTCCGCCGAGGGAGGACAGCGGGGCCTGGCGCTGGCGCCGAGACGCCGCTTAGCGGCCGCCACTGGAGACACT
CCCTCCCGCCTCCCGGGTCTCCTGGCGGCGGCGGAGTGAGGCTGACAGCGGGGAACCTGGGAGACCCCTCCGCCCTCCCCGCGGTGGCAG
CGGCCGATCCCCGGCTCCGGCGCGAGGGACGGCCGCGATGCGCTCGGCCTGAGGTTACCCGGCCCGGCCCTTCCTCGCTTCCCTCGACTA
TTCCACTGCGTCTCCGCGCCCCGGCGTCATCCTGCGAGTCCCTCTGACGGGAGGGAAGATGGCTGCACGGAGCTGGCAGGACGAGCTGGC
CCAGCAGGCCGAGGAGGGCTCGGCCCGGCTGCGGGAAATGCTCTCGGTCGGCCTAGGCTTTCTGCGCACCGAGCTGGGCCTCGACCTGGG
GCTGGAGCCGAAACGGTACCCCGGCTGGGTGATCCTGGTGGGCACTGGCGCGCTCGGGCTGCTGCTGCTGTTTCTGCTGGGCTACGGCTG
GGCCGCGGCTTGCGCCGGCGCCCGCAAAAAGCGGAGGAGCCCGCCCCGCAAGCGGGAGGAGGCGGCGGCCGTGCCGGCCGCGGCCCCCGA
CGACCTGGCCTTGCTGAAGAATCTCCGGAGCGAGGAACAGAAGAAGAAGAACCGGAAGAAACTGTCCGAGAAGCCCAAACCAAATGGGCG
GACTGTTGAAGTGGCTGAGGGTGAAGCTGTTCGAACACCTCAAAGTGTAACAGCAAAGCAGCCACCAGAGATTGACAAGAAAAATGAAAA
GTCAAAGAAAAATAAGAAGAAATCAAAGTCAGATGCTAAAGCAGTGCAAAACAGTTCACGCCATGATGGAAAGGAAGTTGATGAAGGAGC
CTGGGAAACTAAAATTAGTCACAGAGAGAAACGACAGCAGCGTAAACGTGATAAGGTGCTGACTGATTCTGGTTCATTGGATTCAACTAT
CCCTGGGATAGAAAATACCATCACAGTTACCACCGAGCAACTTACAACCGCATCATTTCCTGTTGGTTCCAAGAAGAATAAAGGTGATTC
TCATCTAAATGTTCAAGTTAGCAACTTTAAATCTGGAAAAGGAGATTCTACACTTCAGGTTTCTTCAGGATTGAATGAAAACCTCACTGT
CAATGGAGGAGGCTGGAATGAAAAGTCTGTAAAACTCTCCTCACAGATCAGTGCAGGTGAGGAGAAGTGGAACTCCGTTTCACCTGCTTC
TGCAGGAAAGAGGAAAACTGAGCCATCTGCCTGGAGTCAAGACACTGGAGATGCTAATACAAATGGAAAAGACTGGGGAAGGAGTTGGAG
TGACCGTTCAATATTTTCTGGCATTGGGTCTACTGCTGAGCCAGTTTCTCAGTCTACCACTTCTGATTATCAGTGGGATGTTAGCCGTAA
TCAACCCTATATCGATGATGAATGGTCTGGGTTAAATGGTCTGTCTTCTGCTGATCCCAACTCTGATTGGAATGCACCAGCAGAAGAGTG
GGGCAATTGGGTAGACGAAGAAAGAGCTTCACTTCTAAAGTCCCAGGAACCAATTCCTGATGATCAAAAGGTCTCAGATGATGATAAAGA
AAAGGGAGAGGGAGCTCTTCCAACTGGGAAATCCAAAAAGAAAAAAAAGAAAAAGAAGAAGCAAGGTGAAGATAACTCTACTGCACAGGA
CACAGAAGAATTAGAAAAAGAGATTAGAGAAGACCTTCCAGTGAATACCTCTAAAACCCGTCCAAAACAGGAAAAAGCTTTTTCCTTGAA
GACCATAAGCACTAGTGATCCAGCCGAAGTACTCGTCAAAAATAGCCAGCCTATCAAGACTCTTCCACCTGCTACTTCTACCGAGCCATC
TGTAATCTTATCAAAAAGTGATTCTGACAAGAGCTCTTCCCAAGTGCCGCCAATACTACAAGAGACAGATAAATCCAAGTCAAATACCAA
GCAAAATAGTGTGCCTCCTTCACAGAGAAGTGGTTACCTGGAAGGAAAGGAGCTGCAGAACTTGATCCAGGAGCTCCAGCAGGCGCGAAA
GAAGGCTGGATTGGAGTTATCACCTGAAATGAAAACTTTTGTGGATCAGTATGGGCAAAGAGATGATGGAAAAATAGGAATTGTAGAGTT
GGCTCACGTATTACCCACAGAAGAGAATTTCCTGCTGCTCTTCCGATGCCAGCAGCTGAAGTCCTGTGAGGAATTCATGAAGACATGGAG
AAAATATGATACTGACCACAGTGGCTTCATAGAAACTGAGGAGCTTAAGAACTTTCTAAAGGACCTGCTAGAAAAAGCAAACAAGACTGT
TGATGACACAAAATTAGCCGAGTATACAGACCTAATGCTGAAACTATTTGATTCAAATAATGATGGGAAGCTGGAATTAACTGAGATGGC
CAGGTTACTACCAGTGCAGGAGAATTTTCTTCTTAAATTCCAGGGAATCAAAATGTGTGGGAAAGAGTTCAATAAGGCTTTTGAGCTGTA
TGATCAGGACGGCAATGGATACATAGATGAAAATGAACTGGATGCTTTACTGAAGGATCTGTGCGAGAAGAATAAACAGGATCTGGATAT
TAATAATATTACAACATACAAGAAGAACATAATGGCTTTGTCGGATGGAGGGAAGCTGTACCGAACGGATCTTGCTCTTATTCTCTGTGC
TGGGGATAACTAGAGTTGGTGGCCGCAACCACTTGCTAGTGATACACTGTATCTAAAAAATAACTGTGCACTATAAGGGAGTAGGCTGTA
TTTTCTTTTATATCTGTAAATTTAACTGCATATAGATAATTATCCAGGATGTGTGGCTCATTCTTTTCAGCTTGTTTCTATACTGTTTGT
AATATACAGTTTTTGTAACCATATGATTGAAAAGAAGAAAGTCTATGCTTAGGCCAGTCAGTACACCCAATTTTAAAAAATAACATATTC
TTGCTTTCACAAATATAGTTGAACAAGATTTCCCTAAAAATTCCACCAGGATTAATCTCTAAAATTCTAGTCTCTGATTTGCAAATGCAC
ATTTGTCACTGAATAATGGAATTATGTATAACAAGCCAAACATTCTTATTTTAGACAACCATAGAACTGTCCCACAAAATATTTCTAAGC
TTATTTCTAACTATTAGGAGGAATGTGCTTTTCCATCTAAAATACTCACCAAAATATAGTTAATTGTGGCTTTATGAAGTTAACAGTCTC
ATTACAGATTTAGTTTACCAATCAACAGCATGTCTACTGCTTGGATCCATACAAAACTATCGGTTCAAGTTGATGTGACAAGGGAAGGGA
GCACCAGATGACACATAAATCTGTCTGATTCTATGCCTGTATTTCCAACAAACTTACTGTCAGAGAATATGACCTAAATCCATTTTCTAA
ACTGTTTTCATGTGTTGCAAATTATTCTAGTCAACTGCTGTTTTATGTCATACTCTGTGTAATCTCTGATTAAATTTAATATACTGCATA
TCCTGGTGTCTAGTTTGCATACTTCCTGGATTTTCTTTCTATGTAGAACTGTTCATTTCCACCAAGGGTATCTGCTGCCTCTGAAAATAT
TTTTTTCTAGCTATAACAACTCTATTTTTTACTACATAATTAAATTTTAATGTAAAATTCATAGCATCCTGATTATTGAATGTTATATCA
TCAATACTTTTGTGTATTCTGTGGATTCTATATTTCATATTGAGATCAGCATTCAAAATAGTTCTATTTCTATCTGCAAATAGTTTCAAA
TGAGTTTAAAAAAATAACATCTGAAAAGAAATGCTAATGTAATCATTTATCTTATCTAGCAAGAAGATTCTAAAACATTCTTTAACATAC
ATCTAAGTCAGTTTCACATATTTGTAGCTAGAATATCCTATACTGGTTATAGTTGATATGTAACAGTTGGTGATTTTAGATTTCTTTGAT
TGTGAAACAGGGAGCTATGAGAGATGTGTCCATGTGAAATTTACAGTTACTGCCTAGGAGTTAATGATCGTTCTGGGTCAGCTTGAATGT
CCCCATTCTATAAATTCAACACTTATTTTCTGAATTCATAAAAATAACCAAAAAATGTGAGCTATAATGTTTCCCTCAAGAACAAACAGA
AACGAGATTTGCCAAAAACTAAAATTCAACAAATGATGTTGAGTGGGAGATTGGCTTTGCCTTTAGCGTGTAAATGGAAGCACTGCCATT

>55597_55597_1_MTDH-CALB1_MTDH_chr8_98735263_ENST00000336273_CALB1_chr8_91094330_ENST00000265431_length(amino acids)=803AA_BP=569
MRVPLTGGKMAARSWQDELAQQAEEGSARLREMLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKK
RRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKS
DAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFK
SGKGDSTLQVSSGLNENLTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFSGIGS
TAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGK
SKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSDK
SSSQVPPILQETDKSKSNTKQNSVPPSQRSGYLEGKELQNLIQELQQARKKAGLELSPEMKTFVDQYGQRDDGKIGIVELAHVLPTEENF
LLLFRCQQLKSCEEFMKTWRKYDTDHSGFIETEELKNFLKDLLEKANKTVDDTKLAEYTDLMLKLFDSNNDGKLELTEMARLLPVQENFL

--------------------------------------------------------------
>55597_55597_2_MTDH-CALB1_MTDH_chr8_98735263_ENST00000519934_CALB1_chr8_91094330_ENST00000265431_length(transcript)=3812nt_BP=1540nt
GCCGAGGAGGGCTCGGCCCGGCTGCGGGAAATGCTCTCGGTCGGCCTAGGCTTTCTGCGCACCGAGCTGGGCCTCGACCTGGGGCTGGAG
CCGAAACGGTACCCCGGCTGGGTGATCCTGGTGGGCACTGGCGCGCTCGGGCTGCTGCTGCTGTTTCTGCTGGGCTACGGCTGGGCCGCG
GCTTGCGCCGGCGCCCGCAAAAAGCGGAGGAGCCCGCCCCGCAAGCGGGAGGAGGCGGCGGCCGTGCCGGCCGCGGCCCCCGACGACCTG
GCCTTGCTGAAGAATCTCCGGAGCGAGGAACAGAAGAAGAAGAACCGGAAGAAACTGTCCGAGAAGCCCAAACCAAATGGGCGGACTGTT
GAAGTGGCTGAGGGTGAAGCTGTTCGAACACCTCAAAGTGTAACAGCAAAGCAGCCACCAGAGATTGACAAGAAAAATGAAAAGTCAAAG
AAAAATAAGAAGAAATCAAAGTCAGATGCTAAAGCAGTGCAAAACAGTTCACGCCATGATGGAAAGGAAGTTGATGAAGGAGCCTGGGAA
ACTAAAATTAGTCACAGAGAGAAACGACAGCAGCGTAAACGTGATAAGGTGCTGACTGATTCTGGTTCATTGGATTCAACTATCCCTGGG
ATAGAAAATACCATCACAGTTACCACCGAGCAACTTACAACCGCATCATTTCCTGTTGGTTCCAAGAAGAATAAAGGTGATTCTCATCTA
AATGTTCAAGTTAGCAACTTTAAATCTGGAAAAGGAGATTCTACACTTCAGGTTTCTTCAGGATTGAATGAAAACCTCACTGTCAATGGA
GGAGGCTGGAATGAAAAGTCTGTAAAACTCTCCTCACAGATCAGTGCAGGTGAGGAGAAGTGGAACTCCGTTTCACCTGCTTCTGCAGGA
AAGAGGAAAACTGAGCCATCTGCCTGGAGTCAAGACACTGGAGATGCTAATACAAATGGAAAAGACTGGGGAAGGAGTTGGAGTGACCGT
TCAATATTTTCTGGCATTGATGGTCTGTCTTCTGCTGATCCCAACTCTGATTGGAATGCACCAGCAGAAGAGTGGGGCAATTGGGTAGAC
GAAGAAAGAGCTTCACTTCTAAAGTCCCAGGAACCAATTCCTGATGATCAAAAGGTCTCAGATGATGATAAAGAAAAGGGAGAGGGAGCT
CTTCCAACTGGGAAATCCAAAAAGAAAAAAAAGAAAAAGAAGAAGCAAGGTGAAGATAACTCTACTGCACAGGACACAGAAGAATTAGAA
AAAGAGATTAGAGAAGACCTTCCAGTGAATACCTCTAAAACCCGTCCAAAACAGGAAAAAGCTTTTTCCTTGAAGACCATAAGCACTAGT
GATCCAGCCGAAGTACTCGTCAAAAATAGCCAGCCTATCAAGACTCTTCCACCTGCTACTTCTACCGAGCCATCTGTAATCTTATCAAAA
AGTGATTCTGACAAGAGCTCTTCCCAAGTGCCGCCAATACTACAAGAGACAGATAAATCCAAGTCAAATACCAAGCAAAATAGTGTGCCT
CCTTCACAGAGAAGTGGTTACCTGGAAGGAAAGGAGCTGCAGAACTTGATCCAGGAGCTCCAGCAGGCGCGAAAGAAGGCTGGATTGGAG
TTATCACCTGAAATGAAAACTTTTGTGGATCAGTATGGGCAAAGAGATGATGGAAAAATAGGAATTGTAGAGTTGGCTCACGTATTACCC
ACAGAAGAGAATTTCCTGCTGCTCTTCCGATGCCAGCAGCTGAAGTCCTGTGAGGAATTCATGAAGACATGGAGAAAATATGATACTGAC
CACAGTGGCTTCATAGAAACTGAGGAGCTTAAGAACTTTCTAAAGGACCTGCTAGAAAAAGCAAACAAGACTGTTGATGACACAAAATTA
GCCGAGTATACAGACCTAATGCTGAAACTATTTGATTCAAATAATGATGGGAAGCTGGAATTAACTGAGATGGCCAGGTTACTACCAGTG
CAGGAGAATTTTCTTCTTAAATTCCAGGGAATCAAAATGTGTGGGAAAGAGTTCAATAAGGCTTTTGAGCTGTATGATCAGGACGGCAAT
GGATACATAGATGAAAATGAACTGGATGCTTTACTGAAGGATCTGTGCGAGAAGAATAAACAGGATCTGGATATTAATAATATTACAACA
TACAAGAAGAACATAATGGCTTTGTCGGATGGAGGGAAGCTGTACCGAACGGATCTTGCTCTTATTCTCTGTGCTGGGGATAACTAGAGT
TGGTGGCCGCAACCACTTGCTAGTGATACACTGTATCTAAAAAATAACTGTGCACTATAAGGGAGTAGGCTGTATTTTCTTTTATATCTG
TAAATTTAACTGCATATAGATAATTATCCAGGATGTGTGGCTCATTCTTTTCAGCTTGTTTCTATACTGTTTGTAATATACAGTTTTTGT
AACCATATGATTGAAAAGAAGAAAGTCTATGCTTAGGCCAGTCAGTACACCCAATTTTAAAAAATAACATATTCTTGCTTTCACAAATAT
AGTTGAACAAGATTTCCCTAAAAATTCCACCAGGATTAATCTCTAAAATTCTAGTCTCTGATTTGCAAATGCACATTTGTCACTGAATAA
TGGAATTATGTATAACAAGCCAAACATTCTTATTTTAGACAACCATAGAACTGTCCCACAAAATATTTCTAAGCTTATTTCTAACTATTA
GGAGGAATGTGCTTTTCCATCTAAAATACTCACCAAAATATAGTTAATTGTGGCTTTATGAAGTTAACAGTCTCATTACAGATTTAGTTT
ACCAATCAACAGCATGTCTACTGCTTGGATCCATACAAAACTATCGGTTCAAGTTGATGTGACAAGGGAAGGGAGCACCAGATGACACAT
AAATCTGTCTGATTCTATGCCTGTATTTCCAACAAACTTACTGTCAGAGAATATGACCTAAATCCATTTTCTAAACTGTTTTCATGTGTT
GCAAATTATTCTAGTCAACTGCTGTTTTATGTCATACTCTGTGTAATCTCTGATTAAATTTAATATACTGCATATCCTGGTGTCTAGTTT
GCATACTTCCTGGATTTTCTTTCTATGTAGAACTGTTCATTTCCACCAAGGGTATCTGCTGCCTCTGAAAATATTTTTTTCTAGCTATAA
CAACTCTATTTTTTACTACATAATTAAATTTTAATGTAAAATTCATAGCATCCTGATTATTGAATGTTATATCATCAATACTTTTGTGTA
TTCTGTGGATTCTATATTTCATATTGAGATCAGCATTCAAAATAGTTCTATTTCTATCTGCAAATAGTTTCAAATGAGTTTAAAAAAATA
ACATCTGAAAAGAAATGCTAATGTAATCATTTATCTTATCTAGCAAGAAGATTCTAAAACATTCTTTAACATACATCTAAGTCAGTTTCA
CATATTTGTAGCTAGAATATCCTATACTGGTTATAGTTGATATGTAACAGTTGGTGATTTTAGATTTCTTTGATTGTGAAACAGGGAGCT
ATGAGAGATGTGTCCATGTGAAATTTACAGTTACTGCCTAGGAGTTAATGATCGTTCTGGGTCAGCTTGAATGTCCCCATTCTATAAATT
CAACACTTATTTTCTGAATTCATAAAAATAACCAAAAAATGTGAGCTATAATGTTTCCCTCAAGAACAAACAGAAACGAGATTTGCCAAA
AACTAAAATTCAACAAATGATGTTGAGTGGGAGATTGGCTTTGCCTTTAGCGTGTAAATGGAAGCACTGCCATTAGACTGAATTTAACTA

>55597_55597_2_MTDH-CALB1_MTDH_chr8_98735263_ENST00000519934_CALB1_chr8_91094330_ENST00000265431_length(amino acids)=741AA_BP=507
MREMLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEAAAVPAAAPDDLALLKNLR
SEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHRE
KRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNEKS
VKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFSGIDGLSSADPNSDWNAPAEEWGNWVDEERASLL
KSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLV
KNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQRSGYLEGKELQNLIQELQQARKKAGLELSPEMKT
FVDQYGQRDDGKIGIVELAHVLPTEENFLLLFRCQQLKSCEEFMKTWRKYDTDHSGFIETEELKNFLKDLLEKANKTVDDTKLAEYTDLM
LKLFDSNNDGKLELTEMARLLPVQENFLLKFQGIKMCGKEFNKAFELYDQDGNGYIDENELDALLKDLCEKNKQDLDINNITTYKKNIMA

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Fusion Gene PPI Analysis for MTDH-CALB1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	MTDH	chr8:98735263	chr8:91094330	ENST00000336273	+	11	12	72_169	559.3333333333334	583.0	BCCIP
Hgene	MTDH	chr8:98735263	chr8:91094330	ENST00000336273	+	11	12	101_205	559.3333333333334	583.0	RELA

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	CALB1	chr8:98735263	chr8:91094330	ENST00000265431		0	11	2_7	26.333333333333332	262.0	RANBP9

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MTDH-CALB1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MTDH-CALB1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source