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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MTDH-LAPTM4B (FusionGDB2 ID:55602)

Fusion Gene Summary for MTDH-LAPTM4B

Fusion gene summary

Fusion gene information	Fusion gene name: MTDH-LAPTM4B
	Fusion gene ID: 55602
		Hgene	Tgene
	Gene symbol	MTDH	LAPTM4B
	Gene ID	92140	55353
	Gene name	metadherin	lysosomal protein transmembrane 4 beta
	Synonyms	3D3\|AEG-1\|AEG1\|LYRIC\|LYRIC/3D3	LAPTM4beta\|LC27
	Cytomap	8q22.1	8q22.1
	Type of gene	protein-coding	protein-coding
	Description	protein LYRIC3D3/LYRICastrocyte elevated gene 1astrocyte elevated gene-1 proteinlysine-rich CEACAM1 co-isolated proteinmetastasis adhesion protein	lysosomal-associated transmembrane protein 4Blysosomal associated protein transmembrane 4 betalysosome-associated transmembrane protein 4-beta
	Modification date	20200313	20200313
	UniProtAcc	Q86UE4	Q86VI4
	Ensembl transtripts involved in fusion gene	ENST00000336273, ENST00000519934,	ENST00000445593, ENST00000521545,
Fusion gene scores	* DoF score	15 X 10 X 9=1350	14 X 8 X 8=896
	# samples	20	16
	** MAII score	log2(20/1350*10)=-2.75488750216347 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/896*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MTDH [Title/Abstract] AND LAPTM4B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MTDH(98673401)-LAPTM4B(98817581), # samples:2 LAPTM4B(98817692)-MTDH(98731276), # samples:1 LAPTM4B(98837381)-MTDH(98673300), # samples:1 LAPTM4B(98817692)-MTDH(98731277), # samples:1 LAPTM4B(98788336)-MTDH(98736828), # samples:1 LAPTM4B(98837381)-MTDH(98735107), # samples:1 LAPTM4B(98837381)-MTDH(98736828), # samples:1 LAPTM4B(98837381)-MTDH(98698896), # samples:1 LAPTM4B(98837381)-MTDH(98731277), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MTDH	GO:0000122	negative regulation of transcription by RNA polymerase II	15927426
Hgene	MTDH	GO:0010508	positive regulation of autophagy	21127263
Hgene	MTDH	GO:0043066	negative regulation of apoptotic process	17704808
Hgene	MTDH	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	16452207\|18316612
Hgene	MTDH	GO:0045766	positive regulation of angiogenesis	19940250
Hgene	MTDH	GO:0051092	positive regulation of NF-kappaB transcription factor activity	16452207\|18316612
Hgene	MTDH	GO:0051897	positive regulation of protein kinase B signaling	17704808
Tgene	LAPTM4B	GO:0032509	endosome transport via multivesicular body sorting pathway	25588945
Tgene	LAPTM4B	GO:0032911	negative regulation of transforming growth factor beta1 production	26126825

Fusion gene breakpoints across MTDH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LAPTM4B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	COAD	TCGA-A6-6782-01A	MTDH	chr8	98673401	+	LAPTM4B	chr8	98817581	+
ChimerDB4	OV	TCGA-61-2088-01A	MTDH	chr8	98673401	+	LAPTM4B	chr8	98817581	+

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Fusion Gene ORF analysis for MTDH-LAPTM4B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000336273	ENST00000445593	MTDH	chr8	98673401	+	LAPTM4B	chr8	98817581	+
In-frame	ENST00000336273	ENST00000521545	MTDH	chr8	98673401	+	LAPTM4B	chr8	98817581	+
In-frame	ENST00000519934	ENST00000445593	MTDH	chr8	98673401	+	LAPTM4B	chr8	98817581	+
In-frame	ENST00000519934	ENST00000521545	MTDH	chr8	98673401	+	LAPTM4B	chr8	98817581	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000336273

MTDH

chr8

98673401

ENST00000445593

LAPTM4B

chr8

98817581

2932

811

301

1392

363

ENST00000336273

MTDH

chr8

98673401

ENST00000521545

LAPTM4B

chr8

98817581

1393

811

301

1392

364

ENST00000519934

MTDH

chr8

98673401

ENST00000445593

LAPTM4B

chr8

98817581

2565

444

1025

334

ENST00000519934

MTDH

chr8

98673401

ENST00000521545

LAPTM4B

chr8

98817581

1026

444

1025

334

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000336273	ENST00000445593	MTDH	chr8	98673401	+	LAPTM4B	chr8	98817581	+	0.000620664	0.9993793
ENST00000336273	ENST00000521545	MTDH	chr8	98673401	+	LAPTM4B	chr8	98817581	+	0.003426064	0.9965739
ENST00000519934	ENST00000445593	MTDH	chr8	98673401	+	LAPTM4B	chr8	98817581	+	0.000409979	0.99959
ENST00000519934	ENST00000521545	MTDH	chr8	98673401	+	LAPTM4B	chr8	98817581	+	0.001560712	0.99843925

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Fusion Genomic Features for MTDH-LAPTM4B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MTDH-LAPTM4B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:98673401/chr8:98817581)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MTDH Q86UE4	LAPTM4B Q86VI4
FUNCTION: Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269\|PubMed:15927426, ECO:0000269\|PubMed:16452207, ECO:0000269\|PubMed:18316612, ECO:0000269\|PubMed:19111877}.	FUNCTION: Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656). {ECO:0000269\|PubMed:21224396, ECO:0000269\|PubMed:25588945, ECO:0000269\|PubMed:25998567, ECO:0000269\|PubMed:26126825, ECO:0000269\|PubMed:26280656}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MTDH

chr8:98673401

chr8:98817581

ENST00000336273

59_67

161

583.0

Compositional bias

Note=Poly-Leu

Hgene

MTDH

chr8:98673401

chr8:98817581

ENST00000336273

1_71

161

583.0

Region

Note=Activation of NF-kappa-B

Hgene

MTDH

chr8:98673401

chr8:98817581

ENST00000336273

1_48

161

583.0

Topological domain

Lumenal

Hgene

MTDH

chr8:98673401

chr8:98817581

ENST00000336273

49_69

161

583.0

Transmembrane

Helical

Tgene

LAPTM4B

chr8:98673401

chr8:98817581

ENST00000445593

163_183

124

318.0

Transmembrane

Helical

Tgene

LAPTM4B

chr8:98673401

chr8:98817581

ENST00000445593

191_211

124

318.0

Transmembrane

Helical

Tgene

LAPTM4B

chr8:98673401

chr8:98817581

ENST00000445593

244_264

124

318.0

Transmembrane

Helical

Tgene

LAPTM4B

chr8:98673401

chr8:98817581

ENST00000521545

117_137

227.0

Transmembrane

Helical

Tgene

LAPTM4B

chr8:98673401

chr8:98817581

ENST00000521545

163_183

227.0

Transmembrane

Helical

Tgene

LAPTM4B

chr8:98673401

chr8:98817581

ENST00000521545

191_211

227.0

Transmembrane

Helical

Tgene

LAPTM4B

chr8:98673401

chr8:98817581

ENST00000521545

244_264

227.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MTDH

chr8:98673401

chr8:98817581

ENST00000336273

441_451

161

583.0

Compositional bias

Note=Poly-Lys

Hgene

MTDH

chr8:98673401

chr8:98817581

ENST00000336273

573_577

161

583.0

Compositional bias

Note=Poly-Lys

Hgene

MTDH

chr8:98673401

chr8:98817581

ENST00000336273

381_443

161

583.0

Region

Lung-homing for mammary tumors

Hgene

MTDH

chr8:98673401

chr8:98817581

ENST00000336273

70_582

161

583.0

Topological domain

Cytoplasmic

Tgene

LAPTM4B

chr8:98673401

chr8:98817581

ENST00000445593

117_137

124

318.0

Transmembrane

Helical

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Fusion Gene Sequence for MTDH-LAPTM4B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>55602_55602_1_MTDH-LAPTM4B_MTDH_chr8_98673401_ENST00000336273_LAPTM4B_chr8_98817581_ENST00000445593_length(transcript)=2932nt_BP=811nt
GGCCCAAGCCGCCATTGTTCCGCCGAGGGAGGACAGCGGGGCCTGGCGCTGGCGCCGAGACGCCGCTTAGCGGCCGCCACTGGAGACACT
CCCTCCCGCCTCCCGGGTCTCCTGGCGGCGGCGGAGTGAGGCTGACAGCGGGGAACCTGGGAGACCCCTCCGCCCTCCCCGCGGTGGCAG
CGGCCGATCCCCGGCTCCGGCGCGAGGGACGGCCGCGATGCGCTCGGCCTGAGGTTACCCGGCCCGGCCCTTCCTCGCTTCCCTCGACTA
TTCCACTGCGTCTCCGCGCCCCGGCGTCATCCTGCGAGTCCCTCTGACGGGAGGGAAGATGGCTGCACGGAGCTGGCAGGACGAGCTGGC
CCAGCAGGCCGAGGAGGGCTCGGCCCGGCTGCGGGAAATGCTCTCGGTCGGCCTAGGCTTTCTGCGCACCGAGCTGGGCCTCGACCTGGG
GCTGGAGCCGAAACGGTACCCCGGCTGGGTGATCCTGGTGGGCACTGGCGCGCTCGGGCTGCTGCTGCTGTTTCTGCTGGGCTACGGCTG
GGCCGCGGCTTGCGCCGGCGCCCGCAAAAAGCGGAGGAGCCCGCCCCGCAAGCGGGAGGAGGCGGCGGCCGTGCCGGCCGCGGCCCCCGA
CGACCTGGCCTTGCTGAAGAATCTCCGGAGCGAGGAACAGAAGAAGAAGAACCGGAAGAAACTGTCCGAGAAGCCCAAACCAAATGGGCG
GACTGTTGAAGTGGCTGAGGGTGAAGCTGTTCGAACACCTCAAAGTGTAACAGCAAAGCAGCCACCAGAGATTGACAAGAAAAATGAAAA
GATCATCAATGCTGTGGTACTGTTGATTTTATTGAGTGCCCTGGCTGATCCGGATCAGTATAACTTTTCAAGTTCTGAACTGGGAGGTGA
CTTTGAGTTCATGGATGATGCCAACATGTGCATTGCCATTGCGATTTCTCTTCTCATGATCCTGATATGTGCTATGGCTACTTACGGAGC
GTACAAGCAACGCGCAGCCTGGATCATCCCATTCTTCTGTTACCAGATCTTTGACTTTGCCCTGAACATGTTGGTTGCAATCACTGTGCT
TATTTATCCAAACTCCATTCAGGAATACATACGGCAACTGCCTCCTAATTTTCCCTACAGAGATGATGTCATGTCAGTGAATCCTACCTG
TTTGGTCCTTATTATTCTTCTGTTTATTAGCATTATCTTGACTTTTAAGGGTTACTTGATTAGCTGTGTTTGGAACTGCTACCGATACAT
CAATGGTAGGAACTCCTCTGATGTCCTGGTTTATGTTACCAGCAATGACACTACGGTGCTGCTACCCCCGTATGATGATGCCACTGTGAA
TGGTGCTGCCAAGGAGCCACCGCCACCTTACGTGTCTGCCTAAGCCTTCAAGTGGGCGGAGCTGAGGGCAGCAGCTTGACTTTGCAGACA
TCTGAGCAATAGTTCTGTTATTTCACTTTTGCCATGAGCCTCTCTGAGCTTGTTTGTTGCTGAAATGCTACTTTTTAAAATTTAGATGTT
AGATTGAAAACTGTAGTTTTCAACATATGCTTTGCTGGAACACTGTGATAGATTAACTGTAGAATTCTTCCTGTACGATTGGGGATATAA
TGGGCTTCACTAACCTTCCCTAGGCATTGAAACTTCCCCCAAATCTGATGGACCTAGAAGTCTGCTTTTGTACCTGCTGGGCCCCAAAGT
TGGGCATTTTTCTCTCTGTTCCCTCTCTTTTGAAAATGTAAAATAAAACCAAAAATAGACAACTTTTTCTTCAGCCATTCCAGCATAGAG
AACAAAACCTTATGGAAACAGGAATGTCAATTGTGTAATCATTGTTCTAATTAGGTAAATAGAAGTCCTTATGTATGTGTTACAAGAATT
TCCCCCACAACATCCTTTATGACTGAAGTTCAATGACAGTTTGTGTTTGGTGGTAAAGGATTTTCTCCATGGCCTGAATTAAGACCATTA
GAAAGCACCAGGCCGTGGGAGCAGTGACCATCTGCTGACTGTTCTTGTGGATCTTGTGTCCAGGGACATGGGGTGACATGCCTCGTATGT
GTTAGAGGGTGGAATGGATGTGTTTGGCGCTGCATGGGATCTGGTGCCCCTCTTCTCCTGGATTCACATCCCCACCCAGGGCCCGCTTTT
ACTAAGTGTTCTGCCCTAGATTGGTTCAAGGAGGTCATCCAACTGACTTTATCAAGTGGAATTGGGATATATTTGATATACTTCTGCCTA
ACAACATGGAAAAGGGTTTTCTTTTCCCTGCAAGCTACATCCTACTGCTTTGAACTTCCAAGTATGTCTAGTCACCTTTTAAAATGTAAA
CATTTTCAGAAAAATGAGGATTGCCTTCCTTGTATGCGCTTTTTACCTTGACTACCTGAATTGCAAGGGATTTTTATATATTCATATGTT
ACAAAGTCAGCAACTCTCCTGTTGGTTCATTATTGAATGTGCTGTAAATTAAGTTGTTTGCAATTAAAACAAGGTTTGCCCACATCCAAG
ATGACCTTGTGATTTTGTGCTGATTGTGTCTGAGGACCTTTCCCTCCACATATGGTCTGGCAGATGCACCCAGTTCAGCCTAAGGAGTAG
GCTTTTTTTTGGGGGGGGGAGGTCGGGTGGGGGGGATTTTTAATCTTTTAATTTTCAAGATGGTTAAAATATTGAAATGTTTAAGTGGAT
AACTATATTATTCATAAAATGACTGAGTGAAAACTAATACACTATGAGATGAAAAGTACTTGTCAGGGATTTTCAAGCTTTTGCTCAAGT
AATTACTATGAAATAACAATTTCTAGAAATGAAGAACAATCCGTGGAGAATAAATTACCATTGGTGTGGGGGAAAAAAGCCAAACAGAAG

>55602_55602_1_MTDH-LAPTM4B_MTDH_chr8_98673401_ENST00000336273_LAPTM4B_chr8_98817581_ENST00000445593_length(amino acids)=363AA_BP=1
MRVPLTGGKMAARSWQDELAQQAEEGSARLREMLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKK
RRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKIINAVVLLIL
LSALADPDQYNFSSSELGGDFEFMDDANMCIAIAISLLMILICAMATYGAYKQRAAWIIPFFCYQIFDFALNMLVAITVLIYPNSIQEYI
RQLPPNFPYRDDVMSVNPTCLVLIILLFISIILTFKGYLISCVWNCYRYINGRNSSDVLVYVTSNDTTVLLPPYDDATVNGAAKEPPPPY

--------------------------------------------------------------
>55602_55602_2_MTDH-LAPTM4B_MTDH_chr8_98673401_ENST00000336273_LAPTM4B_chr8_98817581_ENST00000521545_length(transcript)=1393nt_BP=811nt
GGCCCAAGCCGCCATTGTTCCGCCGAGGGAGGACAGCGGGGCCTGGCGCTGGCGCCGAGACGCCGCTTAGCGGCCGCCACTGGAGACACT
CCCTCCCGCCTCCCGGGTCTCCTGGCGGCGGCGGAGTGAGGCTGACAGCGGGGAACCTGGGAGACCCCTCCGCCCTCCCCGCGGTGGCAG
CGGCCGATCCCCGGCTCCGGCGCGAGGGACGGCCGCGATGCGCTCGGCCTGAGGTTACCCGGCCCGGCCCTTCCTCGCTTCCCTCGACTA
TTCCACTGCGTCTCCGCGCCCCGGCGTCATCCTGCGAGTCCCTCTGACGGGAGGGAAGATGGCTGCACGGAGCTGGCAGGACGAGCTGGC
CCAGCAGGCCGAGGAGGGCTCGGCCCGGCTGCGGGAAATGCTCTCGGTCGGCCTAGGCTTTCTGCGCACCGAGCTGGGCCTCGACCTGGG
GCTGGAGCCGAAACGGTACCCCGGCTGGGTGATCCTGGTGGGCACTGGCGCGCTCGGGCTGCTGCTGCTGTTTCTGCTGGGCTACGGCTG
GGCCGCGGCTTGCGCCGGCGCCCGCAAAAAGCGGAGGAGCCCGCCCCGCAAGCGGGAGGAGGCGGCGGCCGTGCCGGCCGCGGCCCCCGA
CGACCTGGCCTTGCTGAAGAATCTCCGGAGCGAGGAACAGAAGAAGAAGAACCGGAAGAAACTGTCCGAGAAGCCCAAACCAAATGGGCG
GACTGTTGAAGTGGCTGAGGGTGAAGCTGTTCGAACACCTCAAAGTGTAACAGCAAAGCAGCCACCAGAGATTGACAAGAAAAATGAAAA
GATCATCAATGCTGTGGTACTGTTGATTTTATTGAGTGCCCTGGCTGATCCGGATCAGTATAACTTTTCAAGTTCTGAACTGGGAGGTGA
CTTTGAGTTCATGGATGATGCCAACATGTGCATTGCCATTGCGATTTCTCTTCTCATGATCCTGATATGTGCTATGGCTACTTACGGAGC
GTACAAGCAACGCGCAGCCTGGATCATCCCATTCTTCTGTTACCAGATCTTTGACTTTGCCCTGAACATGTTGGTTGCAATCACTGTGCT
TATTTATCCAAACTCCATTCAGGAATACATACGGCAACTGCCTCCTAATTTTCCCTACAGAGATGATGTCATGTCAGTGAATCCTACCTG
TTTGGTCCTTATTATTCTTCTGTTTATTAGCATTATCTTGACTTTTAAGGGTTACTTGATTAGCTGTGTTTGGAACTGCTACCGATACAT
CAATGGTAGGAACTCCTCTGATGTCCTGGTTTATGTTACCAGCAATGACACTACGGTGCTGCTACCCCCGTATGATGATGCCACTGTGAA

>55602_55602_2_MTDH-LAPTM4B_MTDH_chr8_98673401_ENST00000336273_LAPTM4B_chr8_98817581_ENST00000521545_length(amino acids)=364AA_BP=1
MRVPLTGGKMAARSWQDELAQQAEEGSARLREMLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKK
RRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKIINAVVLLIL
LSALADPDQYNFSSSELGGDFEFMDDANMCIAIAISLLMILICAMATYGAYKQRAAWIIPFFCYQIFDFALNMLVAITVLIYPNSIQEYI
RQLPPNFPYRDDVMSVNPTCLVLIILLFISIILTFKGYLISCVWNCYRYINGRNSSDVLVYVTSNDTTVLLPPYDDATVNGAAKEPPPPY

--------------------------------------------------------------
>55602_55602_3_MTDH-LAPTM4B_MTDH_chr8_98673401_ENST00000519934_LAPTM4B_chr8_98817581_ENST00000445593_length(transcript)=2565nt_BP=444nt
GCCGAGGAGGGCTCGGCCCGGCTGCGGGAAATGCTCTCGGTCGGCCTAGGCTTTCTGCGCACCGAGCTGGGCCTCGACCTGGGGCTGGAG
CCGAAACGGTACCCCGGCTGGGTGATCCTGGTGGGCACTGGCGCGCTCGGGCTGCTGCTGCTGTTTCTGCTGGGCTACGGCTGGGCCGCG
GCTTGCGCCGGCGCCCGCAAAAAGCGGAGGAGCCCGCCCCGCAAGCGGGAGGAGGCGGCGGCCGTGCCGGCCGCGGCCCCCGACGACCTG
GCCTTGCTGAAGAATCTCCGGAGCGAGGAACAGAAGAAGAAGAACCGGAAGAAACTGTCCGAGAAGCCCAAACCAAATGGGCGGACTGTT
GAAGTGGCTGAGGGTGAAGCTGTTCGAACACCTCAAAGTGTAACAGCAAAGCAGCCACCAGAGATTGACAAGAAAAATGAAAAGATCATC
AATGCTGTGGTACTGTTGATTTTATTGAGTGCCCTGGCTGATCCGGATCAGTATAACTTTTCAAGTTCTGAACTGGGAGGTGACTTTGAG
TTCATGGATGATGCCAACATGTGCATTGCCATTGCGATTTCTCTTCTCATGATCCTGATATGTGCTATGGCTACTTACGGAGCGTACAAG
CAACGCGCAGCCTGGATCATCCCATTCTTCTGTTACCAGATCTTTGACTTTGCCCTGAACATGTTGGTTGCAATCACTGTGCTTATTTAT
CCAAACTCCATTCAGGAATACATACGGCAACTGCCTCCTAATTTTCCCTACAGAGATGATGTCATGTCAGTGAATCCTACCTGTTTGGTC
CTTATTATTCTTCTGTTTATTAGCATTATCTTGACTTTTAAGGGTTACTTGATTAGCTGTGTTTGGAACTGCTACCGATACATCAATGGT
AGGAACTCCTCTGATGTCCTGGTTTATGTTACCAGCAATGACACTACGGTGCTGCTACCCCCGTATGATGATGCCACTGTGAATGGTGCT
GCCAAGGAGCCACCGCCACCTTACGTGTCTGCCTAAGCCTTCAAGTGGGCGGAGCTGAGGGCAGCAGCTTGACTTTGCAGACATCTGAGC
AATAGTTCTGTTATTTCACTTTTGCCATGAGCCTCTCTGAGCTTGTTTGTTGCTGAAATGCTACTTTTTAAAATTTAGATGTTAGATTGA
AAACTGTAGTTTTCAACATATGCTTTGCTGGAACACTGTGATAGATTAACTGTAGAATTCTTCCTGTACGATTGGGGATATAATGGGCTT
CACTAACCTTCCCTAGGCATTGAAACTTCCCCCAAATCTGATGGACCTAGAAGTCTGCTTTTGTACCTGCTGGGCCCCAAAGTTGGGCAT
TTTTCTCTCTGTTCCCTCTCTTTTGAAAATGTAAAATAAAACCAAAAATAGACAACTTTTTCTTCAGCCATTCCAGCATAGAGAACAAAA
CCTTATGGAAACAGGAATGTCAATTGTGTAATCATTGTTCTAATTAGGTAAATAGAAGTCCTTATGTATGTGTTACAAGAATTTCCCCCA
CAACATCCTTTATGACTGAAGTTCAATGACAGTTTGTGTTTGGTGGTAAAGGATTTTCTCCATGGCCTGAATTAAGACCATTAGAAAGCA
CCAGGCCGTGGGAGCAGTGACCATCTGCTGACTGTTCTTGTGGATCTTGTGTCCAGGGACATGGGGTGACATGCCTCGTATGTGTTAGAG
GGTGGAATGGATGTGTTTGGCGCTGCATGGGATCTGGTGCCCCTCTTCTCCTGGATTCACATCCCCACCCAGGGCCCGCTTTTACTAAGT
GTTCTGCCCTAGATTGGTTCAAGGAGGTCATCCAACTGACTTTATCAAGTGGAATTGGGATATATTTGATATACTTCTGCCTAACAACAT
GGAAAAGGGTTTTCTTTTCCCTGCAAGCTACATCCTACTGCTTTGAACTTCCAAGTATGTCTAGTCACCTTTTAAAATGTAAACATTTTC
AGAAAAATGAGGATTGCCTTCCTTGTATGCGCTTTTTACCTTGACTACCTGAATTGCAAGGGATTTTTATATATTCATATGTTACAAAGT
CAGCAACTCTCCTGTTGGTTCATTATTGAATGTGCTGTAAATTAAGTTGTTTGCAATTAAAACAAGGTTTGCCCACATCCAAGATGACCT
TGTGATTTTGTGCTGATTGTGTCTGAGGACCTTTCCCTCCACATATGGTCTGGCAGATGCACCCAGTTCAGCCTAAGGAGTAGGCTTTTT
TTTGGGGGGGGGAGGTCGGGTGGGGGGGATTTTTAATCTTTTAATTTTCAAGATGGTTAAAATATTGAAATGTTTAAGTGGATAACTATA
TTATTCATAAAATGACTGAGTGAAAACTAATACACTATGAGATGAAAAGTACTTGTCAGGGATTTTCAAGCTTTTGCTCAAGTAATTACT
ATGAAATAACAATTTCTAGAAATGAAGAACAATCCGTGGAGAATAAATTACCATTGGTGTGGGGGAAAAAAGCCAAACAGAAGTAGAAAA

>55602_55602_3_MTDH-LAPTM4B_MTDH_chr8_98673401_ENST00000519934_LAPTM4B_chr8_98817581_ENST00000445593_length(amino acids)=334AA_BP=1
MREMLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEAAAVPAAAPDDLALLKNLR
SEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKIINAVVLLILLSALADPDQYNFSSSELGGDFEFMDDANM
CIAIAISLLMILICAMATYGAYKQRAAWIIPFFCYQIFDFALNMLVAITVLIYPNSIQEYIRQLPPNFPYRDDVMSVNPTCLVLIILLFI

--------------------------------------------------------------
>55602_55602_4_MTDH-LAPTM4B_MTDH_chr8_98673401_ENST00000519934_LAPTM4B_chr8_98817581_ENST00000521545_length(transcript)=1026nt_BP=444nt
GCCGAGGAGGGCTCGGCCCGGCTGCGGGAAATGCTCTCGGTCGGCCTAGGCTTTCTGCGCACCGAGCTGGGCCTCGACCTGGGGCTGGAG
CCGAAACGGTACCCCGGCTGGGTGATCCTGGTGGGCACTGGCGCGCTCGGGCTGCTGCTGCTGTTTCTGCTGGGCTACGGCTGGGCCGCG
GCTTGCGCCGGCGCCCGCAAAAAGCGGAGGAGCCCGCCCCGCAAGCGGGAGGAGGCGGCGGCCGTGCCGGCCGCGGCCCCCGACGACCTG
GCCTTGCTGAAGAATCTCCGGAGCGAGGAACAGAAGAAGAAGAACCGGAAGAAACTGTCCGAGAAGCCCAAACCAAATGGGCGGACTGTT
GAAGTGGCTGAGGGTGAAGCTGTTCGAACACCTCAAAGTGTAACAGCAAAGCAGCCACCAGAGATTGACAAGAAAAATGAAAAGATCATC
AATGCTGTGGTACTGTTGATTTTATTGAGTGCCCTGGCTGATCCGGATCAGTATAACTTTTCAAGTTCTGAACTGGGAGGTGACTTTGAG
TTCATGGATGATGCCAACATGTGCATTGCCATTGCGATTTCTCTTCTCATGATCCTGATATGTGCTATGGCTACTTACGGAGCGTACAAG
CAACGCGCAGCCTGGATCATCCCATTCTTCTGTTACCAGATCTTTGACTTTGCCCTGAACATGTTGGTTGCAATCACTGTGCTTATTTAT
CCAAACTCCATTCAGGAATACATACGGCAACTGCCTCCTAATTTTCCCTACAGAGATGATGTCATGTCAGTGAATCCTACCTGTTTGGTC
CTTATTATTCTTCTGTTTATTAGCATTATCTTGACTTTTAAGGGTTACTTGATTAGCTGTGTTTGGAACTGCTACCGATACATCAATGGT
AGGAACTCCTCTGATGTCCTGGTTTATGTTACCAGCAATGACACTACGGTGCTGCTACCCCCGTATGATGATGCCACTGTGAATGGTGCT

>55602_55602_4_MTDH-LAPTM4B_MTDH_chr8_98673401_ENST00000519934_LAPTM4B_chr8_98817581_ENST00000521545_length(amino acids)=334AA_BP=1
MREMLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEAAAVPAAAPDDLALLKNLR
SEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKIINAVVLLILLSALADPDQYNFSSSELGGDFEFMDDANM
CIAIAISLLMILICAMATYGAYKQRAAWIIPFFCYQIFDFALNMLVAITVLIYPNSIQEYIRQLPPNFPYRDDVMSVNPTCLVLIILLFI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MTDH-LAPTM4B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	MTDH	chr8:98673401	chr8:98817581	ENST00000336273	+	2	12	72_169	161.0	583.0	BCCIP
Hgene	MTDH	chr8:98673401	chr8:98817581	ENST00000336273	+	2	12	101_205	161.0	583.0	RELA

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MTDH-LAPTM4B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MTDH-LAPTM4B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source