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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MTDH-SNTB1 (FusionGDB2 ID:55610)

Fusion Gene Summary for MTDH-SNTB1

check button Fusion gene summary
Fusion gene informationFusion gene name: MTDH-SNTB1
Fusion gene ID: 55610
HgeneTgene
Gene symbol

MTDH

SNTB1

Gene ID

92140

6641

Gene namemetadherinsyntrophin beta 1
Synonyms3D3|AEG-1|AEG1|LYRIC|LYRIC/3D359-DAP|A1B|BSYN2|DAPA1B|SNT2|SNT2B1|TIP-43
Cytomap

8q22.1

8q24.12

Type of geneprotein-codingprotein-coding
Descriptionprotein LYRIC3D3/LYRICastrocyte elevated gene 1astrocyte elevated gene-1 proteinlysine-rich CEACAM1 co-isolated proteinmetastasis adhesion proteinbeta-1-syntrophin59 kDa dystrophin-associated protein A1 basic component 1dystrophin-associated protein A1, 59kD, basic component 1syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)syntrophin-2tax interaction protein 43
Modification date2020031320200313
UniProtAcc

Q86UE4

.
Ensembl transtripts involved in fusion geneENST00000336273, ENST00000519934, 
ENST00000519177, ENST00000395601, 
ENST00000517992, 
Fusion gene scores* DoF score15 X 10 X 9=13506 X 6 X 6=216
# samples 208
** MAII scorelog2(20/1350*10)=-2.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/216*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MTDH [Title/Abstract] AND SNTB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMTDH(98657115)-SNTB1(121587465), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMTDH

GO:0000122

negative regulation of transcription by RNA polymerase II

15927426

HgeneMTDH

GO:0010508

positive regulation of autophagy

21127263

HgeneMTDH

GO:0043066

negative regulation of apoptotic process

17704808

HgeneMTDH

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

16452207|18316612

HgeneMTDH

GO:0045766

positive regulation of angiogenesis

19940250

HgeneMTDH

GO:0051092

positive regulation of NF-kappaB transcription factor activity

16452207|18316612

HgeneMTDH

GO:0051897

positive regulation of protein kinase B signaling

17704808


check buttonFusion gene breakpoints across MTDH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SNTB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-B2-3923-01AMTDHchr8

98657115

+SNTB1chr8

121587465

-


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Fusion Gene ORF analysis for MTDH-SNTB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000336273ENST00000519177MTDHchr8

98657115

+SNTB1chr8

121587465

-
5CDS-5UTRENST00000519934ENST00000519177MTDHchr8

98657115

+SNTB1chr8

121587465

-
In-frameENST00000336273ENST00000395601MTDHchr8

98657115

+SNTB1chr8

121587465

-
In-frameENST00000336273ENST00000517992MTDHchr8

98657115

+SNTB1chr8

121587465

-
In-frameENST00000519934ENST00000395601MTDHchr8

98657115

+SNTB1chr8

121587465

-
In-frameENST00000519934ENST00000517992MTDHchr8

98657115

+SNTB1chr8

121587465

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000336273MTDHchr898657115+ENST00000395601SNTB1chr8121587465-44627093011329342
ENST00000336273MTDHchr898657115+ENST00000517992SNTB1chr8121587465-16867093011329342
ENST00000519934MTDHchr898657115+ENST00000395601SNTB1chr8121587465-409534221962313
ENST00000519934MTDHchr898657115+ENST00000517992SNTB1chr8121587465-131934221962313

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000336273ENST00000395601MTDHchr898657115+SNTB1chr8121587465-0.0015291940.99847084
ENST00000336273ENST00000517992MTDHchr898657115+SNTB1chr8121587465-0.0286170970.97138286
ENST00000519934ENST00000395601MTDHchr898657115+SNTB1chr8121587465-0.0010069550.9989931
ENST00000519934ENST00000517992MTDHchr898657115+SNTB1chr8121587465-0.0174951090.9825049

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Fusion Genomic Features for MTDH-SNTB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MTDH-SNTB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:98657115/chr8:121587465)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTDH

Q86UE4

.
FUNCTION: Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTDHchr8:98657115chr8:121587465ENST00000336273+11259_67127583.0Compositional biasNote=Poly-Leu
HgeneMTDHchr8:98657115chr8:121587465ENST00000336273+1121_71127583.0RegionNote=Activation of NF-kappa-B
HgeneMTDHchr8:98657115chr8:121587465ENST00000336273+1121_48127583.0Topological domainLumenal
HgeneMTDHchr8:98657115chr8:121587465ENST00000336273+11249_69127583.0TransmembraneHelical
TgeneSNTB1chr8:98657115chr8:121587465ENST0000039560138482_538332539.0DomainNote=SU
TgeneSNTB1chr8:98657115chr8:121587465ENST0000051799227482_538332539.0DomainNote=SU
TgeneSNTB1chr8:98657115chr8:121587465ENST0000039560138518_538332539.0RegionCalmodulin-binding
TgeneSNTB1chr8:98657115chr8:121587465ENST0000051799227518_538332539.0RegionCalmodulin-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTDHchr8:98657115chr8:121587465ENST00000336273+112441_451127583.0Compositional biasNote=Poly-Lys
HgeneMTDHchr8:98657115chr8:121587465ENST00000336273+112573_577127583.0Compositional biasNote=Poly-Lys
HgeneMTDHchr8:98657115chr8:121587465ENST00000336273+112381_443127583.0RegionLung-homing for mammary tumors
HgeneMTDHchr8:98657115chr8:121587465ENST00000336273+11270_582127583.0Topological domainCytoplasmic
TgeneSNTB1chr8:98657115chr8:121587465ENST00000395601382_10332539.0Compositional biasNote=Poly-Ala
TgeneSNTB1chr8:98657115chr8:121587465ENST00000517992272_10332539.0Compositional biasNote=Poly-Ala
TgeneSNTB1chr8:98657115chr8:121587465ENST0000039560138112_195332539.0DomainPDZ
TgeneSNTB1chr8:98657115chr8:121587465ENST000003956013819_298332539.0DomainPH 1
TgeneSNTB1chr8:98657115chr8:121587465ENST0000039560138322_433332539.0DomainPH 2
TgeneSNTB1chr8:98657115chr8:121587465ENST0000051799227112_195332539.0DomainPDZ
TgeneSNTB1chr8:98657115chr8:121587465ENST000005179922719_298332539.0DomainPH 1
TgeneSNTB1chr8:98657115chr8:121587465ENST0000051799227322_433332539.0DomainPH 2


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Fusion Gene Sequence for MTDH-SNTB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>55610_55610_1_MTDH-SNTB1_MTDH_chr8_98657115_ENST00000336273_SNTB1_chr8_121587465_ENST00000395601_length(transcript)=4462nt_BP=709nt
GGCCCAAGCCGCCATTGTTCCGCCGAGGGAGGACAGCGGGGCCTGGCGCTGGCGCCGAGACGCCGCTTAGCGGCCGCCACTGGAGACACT
CCCTCCCGCCTCCCGGGTCTCCTGGCGGCGGCGGAGTGAGGCTGACAGCGGGGAACCTGGGAGACCCCTCCGCCCTCCCCGCGGTGGCAG
CGGCCGATCCCCGGCTCCGGCGCGAGGGACGGCCGCGATGCGCTCGGCCTGAGGTTACCCGGCCCGGCCCTTCCTCGCTTCCCTCGACTA
TTCCACTGCGTCTCCGCGCCCCGGCGTCATCCTGCGAGTCCCTCTGACGGGAGGGAAGATGGCTGCACGGAGCTGGCAGGACGAGCTGGC
CCAGCAGGCCGAGGAGGGCTCGGCCCGGCTGCGGGAAATGCTCTCGGTCGGCCTAGGCTTTCTGCGCACCGAGCTGGGCCTCGACCTGGG
GCTGGAGCCGAAACGGTACCCCGGCTGGGTGATCCTGGTGGGCACTGGCGCGCTCGGGCTGCTGCTGCTGTTTCTGCTGGGCTACGGCTG
GGCCGCGGCTTGCGCCGGCGCCCGCAAAAAGCGGAGGAGCCCGCCCCGCAAGCGGGAGGAGGCGGCGGCCGTGCCGGCCGCGGCCCCCGA
CGACCTGGCCTTGCTGAAGAATCTCCGGAGCGAGGAACAGAAGAAGAAGAACCGGAAGAAACTGTCCGAGAAGCCCAAAGTGCCAGGGGA
GAGCAAGAAACAGTGGAAACCAGCCCTGGTTGTGCTGACTGAGAAAGACCTTTTAATCTATGACAGCATGCCACGGAGGAAGGAAGCCTG
GTTCAGCCCAGTTCACACATACCCTCTTCTTGCCACCAGGCTGGTCCATTCAGGTCCAGGAAAGGGATCACCCCAGGCTGGTGTGGATCT
GTCCTTTGCAACGCGAACTGGTACCAGGCAAGGGATTGAAACACATCTCTTCAGAGCAGAGACCAGCAGGGACCTCTCCCACTGGACAAG
GAGCATAGTACAGGGTTGCCACAATTCTGCTGAACTCATTGCTGAAATCAGCACTGCTTGCACCTACAAAAACCAGGAGTGCCGTTTGAC
CATACATTATGAGAATGGATTTTCTATTACCACTGAACCACAGGAGGGTGCCTTTCCCAAGACCATCATACAGTCTCCTTATGAAAAGCT
CAAAATGTCTTCAGATGATGGAATCAGGATGCTGTATTTAGATTTTGGAGGCAAAGATGGAGAGATTCAACTGGACCTTCATTCCTGCCC
CAAGCCAATTGTTTTCATCATTCATTCCTTCCTGTCAGCTAAGATTACAAGACTGGGCTTGGTGGCCTGAAGACAGGGGTGACTTGCCTT
TGAGAAAAGAAGGGCTGCAATGCCACCAGAGAACGTGATGTCAGACACCATCTGTAGTGAGCAGCGCACCAGATGTAGCGTGCTACAGTC
AGCTTTAGCTCTCAAGAGTCGTATGTAACTGTCCCAGACTCCTCTGTCAGTTTCAGCAACTACAAGGGATACCCTGCGAAAGTACCATGA
GAAATATCAGAGTAAAACTTTCTAGAACAGTACAAGGTTAAAGAGGTGAGGTGACGGGAAATACACAGCATAGCTTTGAAATAATGACAA
CCAAGGACATGACCATTAGAACAGCATGTGCAGATCTTAATCATCCCAGTTCCTAGGCAACTTGTTCACCAGGTACGCAAGGGCCGAATA
GTTGAGAAATGGACATTCTTACCTACTCCTCCTAGCCCCCTATCCCCAGTAACAGTGATCCCTTTTCTTATTGTGATTTATTTCCTAATT
CTTGCTGAGTTGACTTTCCCTTGTAGGAAAAGAAAAATATTTCAAATAGAAACCCACCTTTTATTTAAGTATGAAGCAGCTGTTACTTTT
TAAAAAATGAATTATCTTTCAATGGTGTAGAATGATTCCAAAGTGTCTCCATTAGCATATACTGAGCAGGAATTAAATAAAGCATCAGAT
ACTGATCTGAGCTGTAAGCTGGTAGAATCTGAGCCAAAGTAGACTGCTTAAATTGATAAGCTTTGCTAAAGAGTTGTATGCACAAAGGAT
GATTAATTCTGGGACTATACTCACACCAAGGTCTGCTGTCTTATAGCCAAGAATTACAGCTTTATTTATAGAGAGTGAATTATGGGTATT
TTTTCAGAAAATATTGTCATCTGATATACACATAAAACAACTCACATTGTTGGAGTTAACTAATTATCCCCATTTCATGGTTTTCAGTGG
CAACTTACTGACCCTTGTTTTTGCCTGTGCTTGTATGCATGCATTTTCAAGCAAGTAATAAAGCAGCCTCATTTAATTCTGGATAATGCT
GGGTTTTACATATAGACTGAATGCTATAATCAAATCTATTGACAGTATCTGCAGTTCTTTCAGAATTCCAGGGAAATAATATAACGACCT
GATATCTTTCTACAGGAATATTTTCAGACATTATATAGCACATTACTGATTTAATGCTTTTACTTTTATCTTTCAAAACAAATTCACTAA
AAATAACACCTATTGATTTTGAAGTCACTTTTCTCAAACCTTGAAAATGAGCTCTAGGATCTCTATAAACATTTCTAACACTTTTCCTGT
AGTTTACATAGACAGACATCTGTTGTTAGACCTGTGTGTTTTTAAAGAATCATATGTTAACAAATACCCATGCAAAGAGCTTCAAAAAGT
GAAACCGTGTTAAAGGAACACAATTTTTCTCACTCAGACATATTTGTTTATTGAATTGCAAAGTTTTATTTTAAATCAGCATTTCCCCAA
AGAATATATCATATGACGCTAGTTCCAAGGGGCTTGACTGAGTGGTGTTTTGCTGGGGGGAGACAGGGGTTTGTTAATACACTTTACTAA
ATACTGAGCTGAAAAATGTTAAATAGATTTCACGATTGCCTCCTTGAAGATTTTAAAGTTCATTGTGGTTCTTCAAGGCGAAATCCGGTG
AACCATTCCTCACACTTACCTACAGGACTCTTTTCTAATGGAGCATCTTGTGAAGCTAGTGGGTTTTTTTGTTGTTGTTATTTGTTTTTT
TTTTTTAATGCTTTAGAAAACACAGCTTTAGGATATTGACTTTTTGTTTATTTCTATTTTCAAATGCTGAAAAGTCAAGTCCCAGTTTGA
ATACCATAGAAAAGCTTTGATGCATTTGTAAATTATATTGCACTCTTTCACTATATATTTTCAAAATCACTGGAATGTTGTTATACAAGA
GAATTATAATTGTGTATTGTAAATAACATATTAAAATACATATATTAATGCCAATAGTTAAATTCAACAATATGTAATCTAAGGTGCTCG
GTTCTACATGAAGTATGAGTTAACTGCTCATAATTAAGTTGCCAAGATTCTATTATATATTTATAGACAAATTAAAATGATCATAATTAC
AAATATGATTTCTTTATCACTTAAGCTTTGGGCTGATTAATATCTGTGTGGGGGTCAATGGAAACTACATTCTCTACATTTATAAACATT
TAATTTAATTATTTATATTTTAGGAAAATATATTTGAATAAAATTAATGCATTTTCTAGAGTAAATTAAAATGTTATTAGCAAGAAATAG
AAAATTTGACTAAGATAATTGTGTATATGAATCATTTTTCCCCCAAGTTAAAATGTATCATAATAGAGAGGCTCTAATGAATCAATTTCC
AATACTCATTTCTTTCTTATTTTGAATTCAAGTTACAATGACTTTACACTGTAGATTTTAATCTTGTCTGATGTGTGCTGGTGTGTATGA
CACAAACTCATAAGTCTGGATCATGCTTGGGTACAGTCAATGAATCAACCGAGTCACTTTGAGGAATTTGTTTTTGTCCAATTTGCTCTG
TGCTCAATCCCATGAATTATTAAATTTACAATGTTTGTCCCCAAATGAAAACCAATATAAATGAATGATGTTTTAATCTGTACTTTATGG
GAAGTTGCCTATTTGTCAGTAGATGTGGTTAAGTGAGTCCTCTGGTGCAGTGACATCCTTTTAAGCCATCTCATAGGGATTTAAAGAAGG
CCAATAGGAATATAGATATTGGTTTTTCTTTCTCTGACTTGAACTAAGTAGGAGAAACCAAACCATAAACCTATTACAAACTACCCAGGC
AGAGGCATTTACTTAATTCATCAACTAGTGCAATTAAAACCCTGAAAACACATGATCCTTGTTGACTCTGCTTGGTTGAAGCAGGAAAGA
ATGGTCTTGATGGTCAGAAAGTTTTAAAATTAATGGGCAGGGCCTTTCTGGACCCTGTTTTCCAAACACGTTAGATATTCCGTCTTGAGG
GGATTGGAGTAGGCTACAGTGAGGGGGTAATTTTTGGATGTATCTGGACTTTTAAAAAATGTGCCTATATTTATAGCACCATGAATATTA

>55610_55610_1_MTDH-SNTB1_MTDH_chr8_98657115_ENST00000336273_SNTB1_chr8_121587465_ENST00000395601_length(amino acids)=342AA_BP=136
MRVPLTGGKMAARSWQDELAQQAEEGSARLREMLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKK
RRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKVPGESKKQWKPALVVLTEKDLLIYDSMPRRKEAWFSPVHTYPLL
ATRLVHSGPGKGSPQAGVDLSFATRTGTRQGIETHLFRAETSRDLSHWTRSIVQGCHNSAELIAEISTACTYKNQECRLTIHYENGFSIT

--------------------------------------------------------------
>55610_55610_2_MTDH-SNTB1_MTDH_chr8_98657115_ENST00000336273_SNTB1_chr8_121587465_ENST00000517992_length(transcript)=1686nt_BP=709nt
GGCCCAAGCCGCCATTGTTCCGCCGAGGGAGGACAGCGGGGCCTGGCGCTGGCGCCGAGACGCCGCTTAGCGGCCGCCACTGGAGACACT
CCCTCCCGCCTCCCGGGTCTCCTGGCGGCGGCGGAGTGAGGCTGACAGCGGGGAACCTGGGAGACCCCTCCGCCCTCCCCGCGGTGGCAG
CGGCCGATCCCCGGCTCCGGCGCGAGGGACGGCCGCGATGCGCTCGGCCTGAGGTTACCCGGCCCGGCCCTTCCTCGCTTCCCTCGACTA
TTCCACTGCGTCTCCGCGCCCCGGCGTCATCCTGCGAGTCCCTCTGACGGGAGGGAAGATGGCTGCACGGAGCTGGCAGGACGAGCTGGC
CCAGCAGGCCGAGGAGGGCTCGGCCCGGCTGCGGGAAATGCTCTCGGTCGGCCTAGGCTTTCTGCGCACCGAGCTGGGCCTCGACCTGGG
GCTGGAGCCGAAACGGTACCCCGGCTGGGTGATCCTGGTGGGCACTGGCGCGCTCGGGCTGCTGCTGCTGTTTCTGCTGGGCTACGGCTG
GGCCGCGGCTTGCGCCGGCGCCCGCAAAAAGCGGAGGAGCCCGCCCCGCAAGCGGGAGGAGGCGGCGGCCGTGCCGGCCGCGGCCCCCGA
CGACCTGGCCTTGCTGAAGAATCTCCGGAGCGAGGAACAGAAGAAGAAGAACCGGAAGAAACTGTCCGAGAAGCCCAAAGTGCCAGGGGA
GAGCAAGAAACAGTGGAAACCAGCCCTGGTTGTGCTGACTGAGAAAGACCTTTTAATCTATGACAGCATGCCACGGAGGAAGGAAGCCTG
GTTCAGCCCAGTTCACACATACCCTCTTCTTGCCACCAGGCTGGTCCATTCAGGTCCAGGAAAGGGATCACCCCAGGCTGGTGTGGATCT
GTCCTTTGCAACGCGAACTGGTACCAGGCAAGGGATTGAAACACATCTCTTCAGAGCAGAGACCAGCAGGGACCTCTCCCACTGGACAAG
GAGCATAGTACAGGGTTGCCACAATTCTGCTGAACTCATTGCTGAAATCAGCACTGCTTGCACCTACAAAAACCAGGAGTGCCGTTTGAC
CATACATTATGAGAATGGATTTTCTATTACCACTGAACCACAGGAGGGTGCCTTTCCCAAGACCATCATACAGTCTCCTTATGAAAAGCT
CAAAATGTCTTCAGATGATGGAATCAGGATGCTGTATTTAGATTTTGGAGGCAAAGATGGAGAGATTCAACTGGACCTTCATTCCTGCCC
CAAGCCAATTGTTTTCATCATTCATTCCTTCCTGTCAGCTAAGATTACAAGACTGGGCTTGGTGGCCTGAAGACAGGGGTGACTTGCCTT
TGAGAAAAGAAGGGCTGCAATGCCACCAGAGAACGTGATGTCAGACACCATCTGTAGTGAGCAGCGCACCAGATGTAGCGTGCTACAGTC
AGCTTTAGCTCTCAAGAGTCGTATGTAACTGTCCCAGACTCCTCTGTCAGTTTCAGCAACTACAAGGGATACCCTGCGAAAGTACCATGA
GAAATATCAGAGTAAAACTTTCTAGAACAGTACAAGGTTAAAGAGGTGAGGTGACGGGAAATACACAGCATAGCTTTGAAATAATGACAA

>55610_55610_2_MTDH-SNTB1_MTDH_chr8_98657115_ENST00000336273_SNTB1_chr8_121587465_ENST00000517992_length(amino acids)=342AA_BP=136
MRVPLTGGKMAARSWQDELAQQAEEGSARLREMLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKK
RRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKVPGESKKQWKPALVVLTEKDLLIYDSMPRRKEAWFSPVHTYPLL
ATRLVHSGPGKGSPQAGVDLSFATRTGTRQGIETHLFRAETSRDLSHWTRSIVQGCHNSAELIAEISTACTYKNQECRLTIHYENGFSIT

--------------------------------------------------------------
>55610_55610_3_MTDH-SNTB1_MTDH_chr8_98657115_ENST00000519934_SNTB1_chr8_121587465_ENST00000395601_length(transcript)=4095nt_BP=342nt
GCCGAGGAGGGCTCGGCCCGGCTGCGGGAAATGCTCTCGGTCGGCCTAGGCTTTCTGCGCACCGAGCTGGGCCTCGACCTGGGGCTGGAG
CCGAAACGGTACCCCGGCTGGGTGATCCTGGTGGGCACTGGCGCGCTCGGGCTGCTGCTGCTGTTTCTGCTGGGCTACGGCTGGGCCGCG
GCTTGCGCCGGCGCCCGCAAAAAGCGGAGGAGCCCGCCCCGCAAGCGGGAGGAGGCGGCGGCCGTGCCGGCCGCGGCCCCCGACGACCTG
GCCTTGCTGAAGAATCTCCGGAGCGAGGAACAGAAGAAGAAGAACCGGAAGAAACTGTCCGAGAAGCCCAAAGTGCCAGGGGAGAGCAAG
AAACAGTGGAAACCAGCCCTGGTTGTGCTGACTGAGAAAGACCTTTTAATCTATGACAGCATGCCACGGAGGAAGGAAGCCTGGTTCAGC
CCAGTTCACACATACCCTCTTCTTGCCACCAGGCTGGTCCATTCAGGTCCAGGAAAGGGATCACCCCAGGCTGGTGTGGATCTGTCCTTT
GCAACGCGAACTGGTACCAGGCAAGGGATTGAAACACATCTCTTCAGAGCAGAGACCAGCAGGGACCTCTCCCACTGGACAAGGAGCATA
GTACAGGGTTGCCACAATTCTGCTGAACTCATTGCTGAAATCAGCACTGCTTGCACCTACAAAAACCAGGAGTGCCGTTTGACCATACAT
TATGAGAATGGATTTTCTATTACCACTGAACCACAGGAGGGTGCCTTTCCCAAGACCATCATACAGTCTCCTTATGAAAAGCTCAAAATG
TCTTCAGATGATGGAATCAGGATGCTGTATTTAGATTTTGGAGGCAAAGATGGAGAGATTCAACTGGACCTTCATTCCTGCCCCAAGCCA
ATTGTTTTCATCATTCATTCCTTCCTGTCAGCTAAGATTACAAGACTGGGCTTGGTGGCCTGAAGACAGGGGTGACTTGCCTTTGAGAAA
AGAAGGGCTGCAATGCCACCAGAGAACGTGATGTCAGACACCATCTGTAGTGAGCAGCGCACCAGATGTAGCGTGCTACAGTCAGCTTTA
GCTCTCAAGAGTCGTATGTAACTGTCCCAGACTCCTCTGTCAGTTTCAGCAACTACAAGGGATACCCTGCGAAAGTACCATGAGAAATAT
CAGAGTAAAACTTTCTAGAACAGTACAAGGTTAAAGAGGTGAGGTGACGGGAAATACACAGCATAGCTTTGAAATAATGACAACCAAGGA
CATGACCATTAGAACAGCATGTGCAGATCTTAATCATCCCAGTTCCTAGGCAACTTGTTCACCAGGTACGCAAGGGCCGAATAGTTGAGA
AATGGACATTCTTACCTACTCCTCCTAGCCCCCTATCCCCAGTAACAGTGATCCCTTTTCTTATTGTGATTTATTTCCTAATTCTTGCTG
AGTTGACTTTCCCTTGTAGGAAAAGAAAAATATTTCAAATAGAAACCCACCTTTTATTTAAGTATGAAGCAGCTGTTACTTTTTAAAAAA
TGAATTATCTTTCAATGGTGTAGAATGATTCCAAAGTGTCTCCATTAGCATATACTGAGCAGGAATTAAATAAAGCATCAGATACTGATC
TGAGCTGTAAGCTGGTAGAATCTGAGCCAAAGTAGACTGCTTAAATTGATAAGCTTTGCTAAAGAGTTGTATGCACAAAGGATGATTAAT
TCTGGGACTATACTCACACCAAGGTCTGCTGTCTTATAGCCAAGAATTACAGCTTTATTTATAGAGAGTGAATTATGGGTATTTTTTCAG
AAAATATTGTCATCTGATATACACATAAAACAACTCACATTGTTGGAGTTAACTAATTATCCCCATTTCATGGTTTTCAGTGGCAACTTA
CTGACCCTTGTTTTTGCCTGTGCTTGTATGCATGCATTTTCAAGCAAGTAATAAAGCAGCCTCATTTAATTCTGGATAATGCTGGGTTTT
ACATATAGACTGAATGCTATAATCAAATCTATTGACAGTATCTGCAGTTCTTTCAGAATTCCAGGGAAATAATATAACGACCTGATATCT
TTCTACAGGAATATTTTCAGACATTATATAGCACATTACTGATTTAATGCTTTTACTTTTATCTTTCAAAACAAATTCACTAAAAATAAC
ACCTATTGATTTTGAAGTCACTTTTCTCAAACCTTGAAAATGAGCTCTAGGATCTCTATAAACATTTCTAACACTTTTCCTGTAGTTTAC
ATAGACAGACATCTGTTGTTAGACCTGTGTGTTTTTAAAGAATCATATGTTAACAAATACCCATGCAAAGAGCTTCAAAAAGTGAAACCG
TGTTAAAGGAACACAATTTTTCTCACTCAGACATATTTGTTTATTGAATTGCAAAGTTTTATTTTAAATCAGCATTTCCCCAAAGAATAT
ATCATATGACGCTAGTTCCAAGGGGCTTGACTGAGTGGTGTTTTGCTGGGGGGAGACAGGGGTTTGTTAATACACTTTACTAAATACTGA
GCTGAAAAATGTTAAATAGATTTCACGATTGCCTCCTTGAAGATTTTAAAGTTCATTGTGGTTCTTCAAGGCGAAATCCGGTGAACCATT
CCTCACACTTACCTACAGGACTCTTTTCTAATGGAGCATCTTGTGAAGCTAGTGGGTTTTTTTGTTGTTGTTATTTGTTTTTTTTTTTTA
ATGCTTTAGAAAACACAGCTTTAGGATATTGACTTTTTGTTTATTTCTATTTTCAAATGCTGAAAAGTCAAGTCCCAGTTTGAATACCAT
AGAAAAGCTTTGATGCATTTGTAAATTATATTGCACTCTTTCACTATATATTTTCAAAATCACTGGAATGTTGTTATACAAGAGAATTAT
AATTGTGTATTGTAAATAACATATTAAAATACATATATTAATGCCAATAGTTAAATTCAACAATATGTAATCTAAGGTGCTCGGTTCTAC
ATGAAGTATGAGTTAACTGCTCATAATTAAGTTGCCAAGATTCTATTATATATTTATAGACAAATTAAAATGATCATAATTACAAATATG
ATTTCTTTATCACTTAAGCTTTGGGCTGATTAATATCTGTGTGGGGGTCAATGGAAACTACATTCTCTACATTTATAAACATTTAATTTA
ATTATTTATATTTTAGGAAAATATATTTGAATAAAATTAATGCATTTTCTAGAGTAAATTAAAATGTTATTAGCAAGAAATAGAAAATTT
GACTAAGATAATTGTGTATATGAATCATTTTTCCCCCAAGTTAAAATGTATCATAATAGAGAGGCTCTAATGAATCAATTTCCAATACTC
ATTTCTTTCTTATTTTGAATTCAAGTTACAATGACTTTACACTGTAGATTTTAATCTTGTCTGATGTGTGCTGGTGTGTATGACACAAAC
TCATAAGTCTGGATCATGCTTGGGTACAGTCAATGAATCAACCGAGTCACTTTGAGGAATTTGTTTTTGTCCAATTTGCTCTGTGCTCAA
TCCCATGAATTATTAAATTTACAATGTTTGTCCCCAAATGAAAACCAATATAAATGAATGATGTTTTAATCTGTACTTTATGGGAAGTTG
CCTATTTGTCAGTAGATGTGGTTAAGTGAGTCCTCTGGTGCAGTGACATCCTTTTAAGCCATCTCATAGGGATTTAAAGAAGGCCAATAG
GAATATAGATATTGGTTTTTCTTTCTCTGACTTGAACTAAGTAGGAGAAACCAAACCATAAACCTATTACAAACTACCCAGGCAGAGGCA
TTTACTTAATTCATCAACTAGTGCAATTAAAACCCTGAAAACACATGATCCTTGTTGACTCTGCTTGGTTGAAGCAGGAAAGAATGGTCT
TGATGGTCAGAAAGTTTTAAAATTAATGGGCAGGGCCTTTCTGGACCCTGTTTTCCAAACACGTTAGATATTCCGTCTTGAGGGGATTGG
AGTAGGCTACAGTGAGGGGGTAATTTTTGGATGTATCTGGACTTTTAAAAAATGTGCCTATATTTATAGCACCATGAATATTATGTAAAA

>55610_55610_3_MTDH-SNTB1_MTDH_chr8_98657115_ENST00000519934_SNTB1_chr8_121587465_ENST00000395601_length(amino acids)=313AA_BP=107
MREMLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEAAAVPAAAPDDLALLKNLR
SEEQKKKNRKKLSEKPKVPGESKKQWKPALVVLTEKDLLIYDSMPRRKEAWFSPVHTYPLLATRLVHSGPGKGSPQAGVDLSFATRTGTR
QGIETHLFRAETSRDLSHWTRSIVQGCHNSAELIAEISTACTYKNQECRLTIHYENGFSITTEPQEGAFPKTIIQSPYEKLKMSSDDGIR

--------------------------------------------------------------
>55610_55610_4_MTDH-SNTB1_MTDH_chr8_98657115_ENST00000519934_SNTB1_chr8_121587465_ENST00000517992_length(transcript)=1319nt_BP=342nt
GCCGAGGAGGGCTCGGCCCGGCTGCGGGAAATGCTCTCGGTCGGCCTAGGCTTTCTGCGCACCGAGCTGGGCCTCGACCTGGGGCTGGAG
CCGAAACGGTACCCCGGCTGGGTGATCCTGGTGGGCACTGGCGCGCTCGGGCTGCTGCTGCTGTTTCTGCTGGGCTACGGCTGGGCCGCG
GCTTGCGCCGGCGCCCGCAAAAAGCGGAGGAGCCCGCCCCGCAAGCGGGAGGAGGCGGCGGCCGTGCCGGCCGCGGCCCCCGACGACCTG
GCCTTGCTGAAGAATCTCCGGAGCGAGGAACAGAAGAAGAAGAACCGGAAGAAACTGTCCGAGAAGCCCAAAGTGCCAGGGGAGAGCAAG
AAACAGTGGAAACCAGCCCTGGTTGTGCTGACTGAGAAAGACCTTTTAATCTATGACAGCATGCCACGGAGGAAGGAAGCCTGGTTCAGC
CCAGTTCACACATACCCTCTTCTTGCCACCAGGCTGGTCCATTCAGGTCCAGGAAAGGGATCACCCCAGGCTGGTGTGGATCTGTCCTTT
GCAACGCGAACTGGTACCAGGCAAGGGATTGAAACACATCTCTTCAGAGCAGAGACCAGCAGGGACCTCTCCCACTGGACAAGGAGCATA
GTACAGGGTTGCCACAATTCTGCTGAACTCATTGCTGAAATCAGCACTGCTTGCACCTACAAAAACCAGGAGTGCCGTTTGACCATACAT
TATGAGAATGGATTTTCTATTACCACTGAACCACAGGAGGGTGCCTTTCCCAAGACCATCATACAGTCTCCTTATGAAAAGCTCAAAATG
TCTTCAGATGATGGAATCAGGATGCTGTATTTAGATTTTGGAGGCAAAGATGGAGAGATTCAACTGGACCTTCATTCCTGCCCCAAGCCA
ATTGTTTTCATCATTCATTCCTTCCTGTCAGCTAAGATTACAAGACTGGGCTTGGTGGCCTGAAGACAGGGGTGACTTGCCTTTGAGAAA
AGAAGGGCTGCAATGCCACCAGAGAACGTGATGTCAGACACCATCTGTAGTGAGCAGCGCACCAGATGTAGCGTGCTACAGTCAGCTTTA
GCTCTCAAGAGTCGTATGTAACTGTCCCAGACTCCTCTGTCAGTTTCAGCAACTACAAGGGATACCCTGCGAAAGTACCATGAGAAATAT
CAGAGTAAAACTTTCTAGAACAGTACAAGGTTAAAGAGGTGAGGTGACGGGAAATACACAGCATAGCTTTGAAATAATGACAACCAAGGA

>55610_55610_4_MTDH-SNTB1_MTDH_chr8_98657115_ENST00000519934_SNTB1_chr8_121587465_ENST00000517992_length(amino acids)=313AA_BP=107
MREMLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEAAAVPAAAPDDLALLKNLR
SEEQKKKNRKKLSEKPKVPGESKKQWKPALVVLTEKDLLIYDSMPRRKEAWFSPVHTYPLLATRLVHSGPGKGSPQAGVDLSFATRTGTR
QGIETHLFRAETSRDLSHWTRSIVQGCHNSAELIAEISTACTYKNQECRLTIHYENGFSITTEPQEGAFPKTIIQSPYEKLKMSSDDGIR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MTDH-SNTB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMTDHchr8:98657115chr8:121587465ENST00000336273+11272_169127.0583.0BCCIP
HgeneMTDHchr8:98657115chr8:121587465ENST00000336273+112101_205127.0583.0RELA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MTDH-SNTB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MTDH-SNTB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource