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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MTF2-BRDT (FusionGDB2 ID:55642)

Fusion Gene Summary for MTF2-BRDT

check button Fusion gene summary
Fusion gene informationFusion gene name: MTF2-BRDT
Fusion gene ID: 55642
HgeneTgene
Gene symbol

MTF2

BRDT

Gene ID

22823

676

Gene namemetal response element binding transcription factor 2bromodomain testis associated
SynonymsM96|PCL2|TDRD19A|dJ976O13.2BRD6|CT9|SPGF21
Cytomap

1p22.1

1p22.1

Type of geneprotein-codingprotein-coding
Descriptionmetal-response element-binding transcription factor 2hPCl2metal regulatory transcription factor 2metal-response element DNA-binding protein M96polycomb-like 2polycomb-like protein 2putative DNA binding proteintudor domain containing 19Abromodomain testis-specific proteinRING3-like proteinbromodomain, testis-specificcancer/testis antigen 9
Modification date2020031320200313
UniProtAcc

Q9Y483

Q58F21

Ensembl transtripts involved in fusion geneENST00000471953, ENST00000370298, 
ENST00000370303, ENST00000540243, 
ENST00000545708, 		ENST00000362005, 
ENST00000370389, ENST00000394530, 
ENST00000399546, ENST00000402388, 
ENST00000484781, 
Fusion gene scores* DoF score11 X 4 X 6=2642 X 4 X 3=24
# samples 133
** MAII scorelog2(13/264*10)=-1.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/24*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MTF2 [Title/Abstract] AND BRDT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMTF2(93545088)-BRDT(92469971), # samples:3
Anticipated loss of major functional domain due to fusion event.MTF2-BRDT seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
MTF2-BRDT seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MTF2-BRDT seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
MTF2-BRDT seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
MTF2-BRDT seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
MTF2-BRDT seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MTF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BRDT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A26G-01AMTF2chr1

93545088

-BRDTchr1

92469971

+
ChimerDB4BRCATCGA-A7-A26G-01AMTF2chr1

93545088

+BRDTchr1

92469971

+
ChimerDB4BRCATCGA-A7-A26G-01AMTF2chr1

93545088

+BRDTchr1

92470676

+
ChimerDB4OVTCGA-25-1320-01AMTF2chr1

93545088

+BRDTchr1

92428275

+


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Fusion Gene ORF analysis for MTF2-BRDT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000471953ENST00000362005MTF2chr1

93545088

+BRDTchr1

92469971

+
3UTR-3CDSENST00000471953ENST00000362005MTF2chr1

93545088

+BRDTchr1

92470676

+
3UTR-3CDSENST00000471953ENST00000370389MTF2chr1

93545088

+BRDTchr1

92469971

+
3UTR-3CDSENST00000471953ENST00000370389MTF2chr1

93545088

+BRDTchr1

92470676

+
3UTR-3CDSENST00000471953ENST00000394530MTF2chr1

93545088

+BRDTchr1

92469971

+
3UTR-3CDSENST00000471953ENST00000394530MTF2chr1

93545088

+BRDTchr1

92470676

+
3UTR-3CDSENST00000471953ENST00000399546MTF2chr1

93545088

+BRDTchr1

92469971

+
3UTR-3CDSENST00000471953ENST00000399546MTF2chr1

93545088

+BRDTchr1

92470676

+
3UTR-3CDSENST00000471953ENST00000402388MTF2chr1

93545088

+BRDTchr1

92469971

+
3UTR-3CDSENST00000471953ENST00000402388MTF2chr1

93545088

+BRDTchr1

92470676

+
3UTR-5UTRENST00000471953ENST00000362005MTF2chr1

93545088

+BRDTchr1

92428275

+
3UTR-5UTRENST00000471953ENST00000394530MTF2chr1

93545088

+BRDTchr1

92428275

+
3UTR-5UTRENST00000471953ENST00000399546MTF2chr1

93545088

+BRDTchr1

92428275

+
3UTR-5UTRENST00000471953ENST00000402388MTF2chr1

93545088

+BRDTchr1

92428275

+
3UTR-intronENST00000471953ENST00000370389MTF2chr1

93545088

+BRDTchr1

92428275

+
3UTR-intronENST00000471953ENST00000484781MTF2chr1

93545088

+BRDTchr1

92469971

+
3UTR-intronENST00000471953ENST00000484781MTF2chr1

93545088

+BRDTchr1

92470676

+
3UTR-intronENST00000471953ENST00000484781MTF2chr1

93545088

+BRDTchr1

92428275

+
5CDS-5UTRENST00000370298ENST00000362005MTF2chr1

93545088

+BRDTchr1

92428275

+
5CDS-5UTRENST00000370298ENST00000394530MTF2chr1

93545088

+BRDTchr1

92428275

+
5CDS-5UTRENST00000370298ENST00000399546MTF2chr1

93545088

+BRDTchr1

92428275

+
5CDS-5UTRENST00000370298ENST00000402388MTF2chr1

93545088

+BRDTchr1

92428275

+
5CDS-5UTRENST00000370303ENST00000362005MTF2chr1

93545088

+BRDTchr1

92428275

+
5CDS-5UTRENST00000370303ENST00000394530MTF2chr1

93545088

+BRDTchr1

92428275

+
5CDS-5UTRENST00000370303ENST00000399546MTF2chr1

93545088

+BRDTchr1

92428275

+
5CDS-5UTRENST00000370303ENST00000402388MTF2chr1

93545088

+BRDTchr1

92428275

+
5CDS-intronENST00000370298ENST00000370389MTF2chr1

93545088

+BRDTchr1

92428275

+
5CDS-intronENST00000370298ENST00000484781MTF2chr1

93545088

+BRDTchr1

92469971

+
5CDS-intronENST00000370298ENST00000484781MTF2chr1

93545088

+BRDTchr1

92470676

+
5CDS-intronENST00000370298ENST00000484781MTF2chr1

93545088

+BRDTchr1

92428275

+
5CDS-intronENST00000370303ENST00000370389MTF2chr1

93545088

+BRDTchr1

92428275

+
5CDS-intronENST00000370303ENST00000484781MTF2chr1

93545088

+BRDTchr1

92469971

+
5CDS-intronENST00000370303ENST00000484781MTF2chr1

93545088

+BRDTchr1

92470676

+
5CDS-intronENST00000370303ENST00000484781MTF2chr1

93545088

+BRDTchr1

92428275

+
5UTR-3CDSENST00000540243ENST00000362005MTF2chr1

93545088

+BRDTchr1

92469971

+
5UTR-3CDSENST00000540243ENST00000362005MTF2chr1

93545088

+BRDTchr1

92470676

+
5UTR-3CDSENST00000540243ENST00000370389MTF2chr1

93545088

+BRDTchr1

92469971

+
5UTR-3CDSENST00000540243ENST00000370389MTF2chr1

93545088

+BRDTchr1

92470676

+
5UTR-3CDSENST00000540243ENST00000394530MTF2chr1

93545088

+BRDTchr1

92469971

+
5UTR-3CDSENST00000540243ENST00000394530MTF2chr1

93545088

+BRDTchr1

92470676

+
5UTR-3CDSENST00000540243ENST00000399546MTF2chr1

93545088

+BRDTchr1

92469971

+
5UTR-3CDSENST00000540243ENST00000399546MTF2chr1

93545088

+BRDTchr1

92470676

+
5UTR-3CDSENST00000540243ENST00000402388MTF2chr1

93545088

+BRDTchr1

92469971

+
5UTR-3CDSENST00000540243ENST00000402388MTF2chr1

93545088

+BRDTchr1

92470676

+
5UTR-3CDSENST00000545708ENST00000362005MTF2chr1

93545088

+BRDTchr1

92469971

+
5UTR-3CDSENST00000545708ENST00000362005MTF2chr1

93545088

+BRDTchr1

92470676

+
5UTR-3CDSENST00000545708ENST00000370389MTF2chr1

93545088

+BRDTchr1

92469971

+
5UTR-3CDSENST00000545708ENST00000370389MTF2chr1

93545088

+BRDTchr1

92470676

+
5UTR-3CDSENST00000545708ENST00000394530MTF2chr1

93545088

+BRDTchr1

92469971

+
5UTR-3CDSENST00000545708ENST00000394530MTF2chr1

93545088

+BRDTchr1

92470676

+
5UTR-3CDSENST00000545708ENST00000399546MTF2chr1

93545088

+BRDTchr1

92469971

+
5UTR-3CDSENST00000545708ENST00000399546MTF2chr1

93545088

+BRDTchr1

92470676

+
5UTR-3CDSENST00000545708ENST00000402388MTF2chr1

93545088

+BRDTchr1

92469971

+
5UTR-3CDSENST00000545708ENST00000402388MTF2chr1

93545088

+BRDTchr1

92470676

+
5UTR-5UTRENST00000540243ENST00000362005MTF2chr1

93545088

+BRDTchr1

92428275

+
5UTR-5UTRENST00000540243ENST00000394530MTF2chr1

93545088

+BRDTchr1

92428275

+
5UTR-5UTRENST00000540243ENST00000399546MTF2chr1

93545088

+BRDTchr1

92428275

+
5UTR-5UTRENST00000540243ENST00000402388MTF2chr1

93545088

+BRDTchr1

92428275

+
5UTR-5UTRENST00000545708ENST00000362005MTF2chr1

93545088

+BRDTchr1

92428275

+
5UTR-5UTRENST00000545708ENST00000394530MTF2chr1

93545088

+BRDTchr1

92428275

+
5UTR-5UTRENST00000545708ENST00000399546MTF2chr1

93545088

+BRDTchr1

92428275

+
5UTR-5UTRENST00000545708ENST00000402388MTF2chr1

93545088

+BRDTchr1

92428275

+
5UTR-intronENST00000540243ENST00000370389MTF2chr1

93545088

+BRDTchr1

92428275

+
5UTR-intronENST00000540243ENST00000484781MTF2chr1

93545088

+BRDTchr1

92469971

+
5UTR-intronENST00000540243ENST00000484781MTF2chr1

93545088

+BRDTchr1

92470676

+
5UTR-intronENST00000540243ENST00000484781MTF2chr1

93545088

+BRDTchr1

92428275

+
5UTR-intronENST00000545708ENST00000370389MTF2chr1

93545088

+BRDTchr1

92428275

+
5UTR-intronENST00000545708ENST00000484781MTF2chr1

93545088

+BRDTchr1

92469971

+
5UTR-intronENST00000545708ENST00000484781MTF2chr1

93545088

+BRDTchr1

92470676

+
5UTR-intronENST00000545708ENST00000484781MTF2chr1

93545088

+BRDTchr1

92428275

+
Frame-shiftENST00000370298ENST00000362005MTF2chr1

93545088

+BRDTchr1

92469971

+
Frame-shiftENST00000370298ENST00000370389MTF2chr1

93545088

+BRDTchr1

92469971

+
Frame-shiftENST00000370298ENST00000394530MTF2chr1

93545088

+BRDTchr1

92469971

+
Frame-shiftENST00000370298ENST00000399546MTF2chr1

93545088

+BRDTchr1

92469971

+
Frame-shiftENST00000370298ENST00000402388MTF2chr1

93545088

+BRDTchr1

92469971

+
Frame-shiftENST00000370303ENST00000362005MTF2chr1

93545088

+BRDTchr1

92469971

+
Frame-shiftENST00000370303ENST00000370389MTF2chr1

93545088

+BRDTchr1

92469971

+
Frame-shiftENST00000370303ENST00000394530MTF2chr1

93545088

+BRDTchr1

92469971

+
Frame-shiftENST00000370303ENST00000399546MTF2chr1

93545088

+BRDTchr1

92469971

+
Frame-shiftENST00000370303ENST00000402388MTF2chr1

93545088

+BRDTchr1

92469971

+
In-frameENST00000370298ENST00000362005MTF2chr1

93545088

+BRDTchr1

92470676

+
In-frameENST00000370298ENST00000370389MTF2chr1

93545088

+BRDTchr1

92470676

+
In-frameENST00000370298ENST00000394530MTF2chr1

93545088

+BRDTchr1

92470676

+
In-frameENST00000370298ENST00000399546MTF2chr1

93545088

+BRDTchr1

92470676

+
In-frameENST00000370298ENST00000402388MTF2chr1

93545088

+BRDTchr1

92470676

+
In-frameENST00000370303ENST00000362005MTF2chr1

93545088

+BRDTchr1

92470676

+
In-frameENST00000370303ENST00000370389MTF2chr1

93545088

+BRDTchr1

92470676

+
In-frameENST00000370303ENST00000394530MTF2chr1

93545088

+BRDTchr1

92470676

+
In-frameENST00000370303ENST00000399546MTF2chr1

93545088

+BRDTchr1

92470676

+
In-frameENST00000370303ENST00000402388MTF2chr1

93545088

+BRDTchr1

92470676

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000370298MTF2chr193545088+ENST00000362005BRDTchr192470676+6912943470116
ENST00000370298MTF2chr193545088+ENST00000370389BRDTchr192470676+6912943470116
ENST00000370298MTF2chr193545088+ENST00000399546BRDTchr192470676+6962943470116
ENST00000370298MTF2chr193545088+ENST00000394530BRDTchr192470676+6882943470116
ENST00000370298MTF2chr193545088+ENST00000402388BRDTchr192470676+6912943470116
ENST00000370303MTF2chr193545088+ENST00000362005BRDTchr192470676+618221274291
ENST00000370303MTF2chr193545088+ENST00000370389BRDTchr192470676+618221274291
ENST00000370303MTF2chr193545088+ENST00000399546BRDTchr192470676+623221274291
ENST00000370303MTF2chr193545088+ENST00000394530BRDTchr192470676+615221274291
ENST00000370303MTF2chr193545088+ENST00000402388BRDTchr192470676+618221274291

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000370298ENST00000362005MTF2chr193545088+BRDTchr192470676+0.0944363850.9055636
ENST00000370298ENST00000370389MTF2chr193545088+BRDTchr192470676+0.0944363850.9055636
ENST00000370298ENST00000399546MTF2chr193545088+BRDTchr192470676+0.08765140.91234857
ENST00000370298ENST00000394530MTF2chr193545088+BRDTchr192470676+0.0941514750.90584856
ENST00000370298ENST00000402388MTF2chr193545088+BRDTchr192470676+0.0944363850.9055636
ENST00000370303ENST00000362005MTF2chr193545088+BRDTchr192470676+0.101086240.89891374
ENST00000370303ENST00000370389MTF2chr193545088+BRDTchr192470676+0.101086240.89891374
ENST00000370303ENST00000399546MTF2chr193545088+BRDTchr192470676+0.0984599440.90154
ENST00000370303ENST00000394530MTF2chr193545088+BRDTchr192470676+0.0902968940.90970314
ENST00000370303ENST00000402388MTF2chr193545088+BRDTchr192470676+0.101086240.89891374

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Fusion Genomic Features for MTF2-BRDT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MTF2-BRDT


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:93545088/chr1:92469971)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTF2

Q9Y483

BRDT

Q58F21

FUNCTION: Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:23142980, PubMed:23228662, PubMed:31959557). Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation (By similarity). Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (By similarity). Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (By similarity). In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (By similarity). Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity). {ECO:0000250|UniProtKB:Q02395, ECO:0000269|PubMed:23142980, ECO:0000269|PubMed:23228662, ECO:0000269|PubMed:31959557}.FUNCTION: Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis (PubMed:22464331, PubMed:22901802). Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time (PubMed:22901802). In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA (PubMed:22901802). Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac) (By similarity). Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids (By similarity). Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin. {ECO:0000250|UniProtKB:Q91Y44, ECO:0000269|PubMed:15647849, ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:22901802, ECO:0000269|PubMed:9367677}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTF2chr1:93545088chr1:92470676ENST00000370298+11544_1011594.0DomainNote=Tudor
HgeneMTF2chr1:93545088chr1:92470676ENST00000370303+11444_1011537.0DomainNote=Tudor
HgeneMTF2chr1:93545088chr1:92470676ENST00000540243+11344_1010492.0DomainNote=Tudor
HgeneMTF2chr1:93545088chr1:92470676ENST00000545708+11644_1010492.0DomainNote=Tudor
HgeneMTF2chr1:93545088chr1:92470676ENST00000370298+115102_1571594.0Zinc fingerPHD-type 1
HgeneMTF2chr1:93545088chr1:92470676ENST00000370298+115201_2551594.0Zinc fingerPHD-type 2
HgeneMTF2chr1:93545088chr1:92470676ENST00000370303+114102_1571537.0Zinc fingerPHD-type 1
HgeneMTF2chr1:93545088chr1:92470676ENST00000370303+114201_2551537.0Zinc fingerPHD-type 2
HgeneMTF2chr1:93545088chr1:92470676ENST00000540243+113102_1570492.0Zinc fingerPHD-type 1
HgeneMTF2chr1:93545088chr1:92470676ENST00000540243+113201_2550492.0Zinc fingerPHD-type 2
HgeneMTF2chr1:93545088chr1:92470676ENST00000545708+116102_1570492.0Zinc fingerPHD-type 1
HgeneMTF2chr1:93545088chr1:92470676ENST00000545708+116201_2550492.0Zinc fingerPHD-type 2
TgeneBRDTchr1:93545088chr1:92470676ENST000003620051720417_470864948.0Coiled coilOntology_term=ECO:0000255
TgeneBRDTchr1:93545088chr1:92470676ENST000003620051720591_621864948.0Coiled coilOntology_term=ECO:0000255
TgeneBRDTchr1:93545088chr1:92470676ENST000003703891619417_470791875.0Coiled coilOntology_term=ECO:0000255
TgeneBRDTchr1:93545088chr1:92470676ENST000003703891619591_621791875.0Coiled coilOntology_term=ECO:0000255
TgeneBRDTchr1:93545088chr1:92470676ENST000003945301518417_470818902.0Coiled coilOntology_term=ECO:0000255
TgeneBRDTchr1:93545088chr1:92470676ENST000003945301518591_621818902.0Coiled coilOntology_term=ECO:0000255
TgeneBRDTchr1:93545088chr1:92470676ENST000003995461619417_470864948.0Coiled coilOntology_term=ECO:0000255
TgeneBRDTchr1:93545088chr1:92470676ENST000003995461619591_621864948.0Coiled coilOntology_term=ECO:0000255
TgeneBRDTchr1:93545088chr1:92470676ENST000004023881619417_470864948.0Coiled coilOntology_term=ECO:0000255
TgeneBRDTchr1:93545088chr1:92470676ENST000004023881619591_621864948.0Coiled coilOntology_term=ECO:0000255
TgeneBRDTchr1:93545088chr1:92470676ENST000003620051720635_667864948.0Compositional biasNote=Ser-rich
TgeneBRDTchr1:93545088chr1:92470676ENST000003703891619635_667791875.0Compositional biasNote=Ser-rich
TgeneBRDTchr1:93545088chr1:92470676ENST000003945301518635_667818902.0Compositional biasNote=Ser-rich
TgeneBRDTchr1:93545088chr1:92470676ENST000003995461619635_667864948.0Compositional biasNote=Ser-rich
TgeneBRDTchr1:93545088chr1:92470676ENST000004023881619635_667864948.0Compositional biasNote=Ser-rich
TgeneBRDTchr1:93545088chr1:92470676ENST000003620051720287_359864948.0DomainBromo 2
TgeneBRDTchr1:93545088chr1:92470676ENST00000362005172044_116864948.0DomainBromo 1
TgeneBRDTchr1:93545088chr1:92470676ENST000003620051720500_582864948.0DomainNET
TgeneBRDTchr1:93545088chr1:92470676ENST000003703891619287_359791875.0DomainBromo 2
TgeneBRDTchr1:93545088chr1:92470676ENST00000370389161944_116791875.0DomainBromo 1
TgeneBRDTchr1:93545088chr1:92470676ENST000003703891619500_582791875.0DomainNET
TgeneBRDTchr1:93545088chr1:92470676ENST000003945301518287_359818902.0DomainBromo 2
TgeneBRDTchr1:93545088chr1:92470676ENST00000394530151844_116818902.0DomainBromo 1
TgeneBRDTchr1:93545088chr1:92470676ENST000003945301518500_582818902.0DomainNET
TgeneBRDTchr1:93545088chr1:92470676ENST000003995461619287_359864948.0DomainBromo 2
TgeneBRDTchr1:93545088chr1:92470676ENST00000399546161944_116864948.0DomainBromo 1
TgeneBRDTchr1:93545088chr1:92470676ENST000003995461619500_582864948.0DomainNET
TgeneBRDTchr1:93545088chr1:92470676ENST000004023881619287_359864948.0DomainBromo 2
TgeneBRDTchr1:93545088chr1:92470676ENST00000402388161944_116864948.0DomainBromo 1
TgeneBRDTchr1:93545088chr1:92470676ENST000004023881619500_582864948.0DomainNET
TgeneBRDTchr1:93545088chr1:92470676ENST000003620051720209_220864948.0MotifNuclear localization signal
TgeneBRDTchr1:93545088chr1:92470676ENST000003703891619209_220791875.0MotifNuclear localization signal
TgeneBRDTchr1:93545088chr1:92470676ENST000003945301518209_220818902.0MotifNuclear localization signal
TgeneBRDTchr1:93545088chr1:92470676ENST000003995461619209_220864948.0MotifNuclear localization signal
TgeneBRDTchr1:93545088chr1:92470676ENST000004023881619209_220864948.0MotifNuclear localization signal


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Fusion Gene Sequence for MTF2-BRDT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>55642_55642_1_MTF2-BRDT_MTF2_chr1_93545088_ENST00000370298_BRDT_chr1_92470676_ENST00000362005_length(transcript)=691nt_BP=294nt
GCCATTCGGCACCGGAGTCGCTCCGCGCTCCCAGAATGCACCGGCAGTCCGCGGGAAACCAAAATGGCGAGGGGCTGTATTGAAGTGGGC
TGTGTTTGAGGCCGGTGTAAGAACGCTCATTCTACCCCCAACCCTTGTCTCCAAGGACCTCGGTTTGTGCGTGCATATGTGCCGGGTACC
CGGTGGGGCGGGTGCCCAGTAAGTGCTCGGACTCGCAGGGGAAGCGCCCACGGGGACGGATTGGTTGTTTTTTCCTGTATGAAGCGGTTG
GCACCACTGAAGTGACCGAATGAGGGATCTTGGGAATGGATTGACTGTAGAATCTTTTTCAAATAAAATACAAAACAAGTGCTCTGGAGA
AGAGCAGAAAGAACATCAGCAGTCATCAGAAGCTCAAGATAAATCCAAACTCTGGCTTCTCAAAGACCGTGATTTAGCAAGGCAGAAAGA
ACAAGAGAGGAGGAGGAGAGAAGCAATGGTGGGTACCATTGATATGACCCTTCAAAGTGACATTATGACAATGTTTGAAAACAACTTTGA
TTAAAACTCAGTTTTTAAATTAACCATCAACTTAAAATGAATGGTAAAAGATCAAAATGCATATGGTAAAATGATTGCTTTCAGATAACA

>55642_55642_1_MTF2-BRDT_MTF2_chr1_93545088_ENST00000370298_BRDT_chr1_92470676_ENST00000362005_length(amino acids)=116AA_BP=1
MFCILFEKDSTVNPFPRSLIRSLQWCQPLHTGKNNQSVPVGASPASPSTYWAPAPPGTRHICTHKPRSLETRVGGRMSVLTPASNTAHFN

--------------------------------------------------------------
>55642_55642_2_MTF2-BRDT_MTF2_chr1_93545088_ENST00000370298_BRDT_chr1_92470676_ENST00000370389_length(transcript)=691nt_BP=294nt
GCCATTCGGCACCGGAGTCGCTCCGCGCTCCCAGAATGCACCGGCAGTCCGCGGGAAACCAAAATGGCGAGGGGCTGTATTGAAGTGGGC
TGTGTTTGAGGCCGGTGTAAGAACGCTCATTCTACCCCCAACCCTTGTCTCCAAGGACCTCGGTTTGTGCGTGCATATGTGCCGGGTACC
CGGTGGGGCGGGTGCCCAGTAAGTGCTCGGACTCGCAGGGGAAGCGCCCACGGGGACGGATTGGTTGTTTTTTCCTGTATGAAGCGGTTG
GCACCACTGAAGTGACCGAATGAGGGATCTTGGGAATGGATTGACTGTAGAATCTTTTTCAAATAAAATACAAAACAAGTGCTCTGGAGA
AGAGCAGAAAGAACATCAGCAGTCATCAGAAGCTCAAGATAAATCCAAACTCTGGCTTCTCAAAGACCGTGATTTAGCAAGGCAGAAAGA
ACAAGAGAGGAGGAGGAGAGAAGCAATGGTGGGTACCATTGATATGACCCTTCAAAGTGACATTATGACAATGTTTGAAAACAACTTTGA
TTAAAACTCAGTTTTTAAATTAACCATCAACTTAAAATGAATGGTAAAAGATCAAAATGCATATGGTAAAATGATTGCTTTCAGATAACA

>55642_55642_2_MTF2-BRDT_MTF2_chr1_93545088_ENST00000370298_BRDT_chr1_92470676_ENST00000370389_length(amino acids)=116AA_BP=1
MFCILFEKDSTVNPFPRSLIRSLQWCQPLHTGKNNQSVPVGASPASPSTYWAPAPPGTRHICTHKPRSLETRVGGRMSVLTPASNTAHFN

--------------------------------------------------------------
>55642_55642_3_MTF2-BRDT_MTF2_chr1_93545088_ENST00000370298_BRDT_chr1_92470676_ENST00000394530_length(transcript)=688nt_BP=294nt
GCCATTCGGCACCGGAGTCGCTCCGCGCTCCCAGAATGCACCGGCAGTCCGCGGGAAACCAAAATGGCGAGGGGCTGTATTGAAGTGGGC
TGTGTTTGAGGCCGGTGTAAGAACGCTCATTCTACCCCCAACCCTTGTCTCCAAGGACCTCGGTTTGTGCGTGCATATGTGCCGGGTACC
CGGTGGGGCGGGTGCCCAGTAAGTGCTCGGACTCGCAGGGGAAGCGCCCACGGGGACGGATTGGTTGTTTTTTCCTGTATGAAGCGGTTG
GCACCACTGAAGTGACCGAATGAGGGATCTTGGGAATGGATTGACTGTAGAATCTTTTTCAAATAAAATACAAAACAAGTGCTCTGGAGA
AGAGCAGAAAGAACATCAGCAGTCATCAGAAGCTCAAGATAAATCCAAACTCTGGCTTCTCAAAGACCGTGATTTAGCAAGGCAGAAAGA
ACAAGAGAGGAGGAGGAGAGAAGCAATGGTGGGTACCATTGATATGACCCTTCAAAGTGACATTATGACAATGTTTGAAAACAACTTTGA
TTAAAACTCAGTTTTTAAATTAACCATCAACTTAAAATGAATGGTAAAAGATCAAAATGCATATGGTAAAATGATTGCTTTCAGATAACA

>55642_55642_3_MTF2-BRDT_MTF2_chr1_93545088_ENST00000370298_BRDT_chr1_92470676_ENST00000394530_length(amino acids)=116AA_BP=1
MFCILFEKDSTVNPFPRSLIRSLQWCQPLHTGKNNQSVPVGASPASPSTYWAPAPPGTRHICTHKPRSLETRVGGRMSVLTPASNTAHFN

--------------------------------------------------------------
>55642_55642_4_MTF2-BRDT_MTF2_chr1_93545088_ENST00000370298_BRDT_chr1_92470676_ENST00000399546_length(transcript)=696nt_BP=294nt
GCCATTCGGCACCGGAGTCGCTCCGCGCTCCCAGAATGCACCGGCAGTCCGCGGGAAACCAAAATGGCGAGGGGCTGTATTGAAGTGGGC
TGTGTTTGAGGCCGGTGTAAGAACGCTCATTCTACCCCCAACCCTTGTCTCCAAGGACCTCGGTTTGTGCGTGCATATGTGCCGGGTACC
CGGTGGGGCGGGTGCCCAGTAAGTGCTCGGACTCGCAGGGGAAGCGCCCACGGGGACGGATTGGTTGTTTTTTCCTGTATGAAGCGGTTG
GCACCACTGAAGTGACCGAATGAGGGATCTTGGGAATGGATTGACTGTAGAATCTTTTTCAAATAAAATACAAAACAAGTGCTCTGGAGA
AGAGCAGAAAGAACATCAGCAGTCATCAGAAGCTCAAGATAAATCCAAACTCTGGCTTCTCAAAGACCGTGATTTAGCAAGGCAGAAAGA
ACAAGAGAGGAGGAGGAGAGAAGCAATGGTGGGTACCATTGATATGACCCTTCAAAGTGACATTATGACAATGTTTGAAAACAACTTTGA
TTAAAACTCAGTTTTTAAATTAACCATCAACTTAAAATGAATGGTAAAAGATCAAAATGCATATGGTAAAATGATTGCTTTCAGATAACA

>55642_55642_4_MTF2-BRDT_MTF2_chr1_93545088_ENST00000370298_BRDT_chr1_92470676_ENST00000399546_length(amino acids)=116AA_BP=1
MFCILFEKDSTVNPFPRSLIRSLQWCQPLHTGKNNQSVPVGASPASPSTYWAPAPPGTRHICTHKPRSLETRVGGRMSVLTPASNTAHFN

--------------------------------------------------------------
>55642_55642_5_MTF2-BRDT_MTF2_chr1_93545088_ENST00000370298_BRDT_chr1_92470676_ENST00000402388_length(transcript)=691nt_BP=294nt
GCCATTCGGCACCGGAGTCGCTCCGCGCTCCCAGAATGCACCGGCAGTCCGCGGGAAACCAAAATGGCGAGGGGCTGTATTGAAGTGGGC
TGTGTTTGAGGCCGGTGTAAGAACGCTCATTCTACCCCCAACCCTTGTCTCCAAGGACCTCGGTTTGTGCGTGCATATGTGCCGGGTACC
CGGTGGGGCGGGTGCCCAGTAAGTGCTCGGACTCGCAGGGGAAGCGCCCACGGGGACGGATTGGTTGTTTTTTCCTGTATGAAGCGGTTG
GCACCACTGAAGTGACCGAATGAGGGATCTTGGGAATGGATTGACTGTAGAATCTTTTTCAAATAAAATACAAAACAAGTGCTCTGGAGA
AGAGCAGAAAGAACATCAGCAGTCATCAGAAGCTCAAGATAAATCCAAACTCTGGCTTCTCAAAGACCGTGATTTAGCAAGGCAGAAAGA
ACAAGAGAGGAGGAGGAGAGAAGCAATGGTGGGTACCATTGATATGACCCTTCAAAGTGACATTATGACAATGTTTGAAAACAACTTTGA
TTAAAACTCAGTTTTTAAATTAACCATCAACTTAAAATGAATGGTAAAAGATCAAAATGCATATGGTAAAATGATTGCTTTCAGATAACA

>55642_55642_5_MTF2-BRDT_MTF2_chr1_93545088_ENST00000370298_BRDT_chr1_92470676_ENST00000402388_length(amino acids)=116AA_BP=1
MFCILFEKDSTVNPFPRSLIRSLQWCQPLHTGKNNQSVPVGASPASPSTYWAPAPPGTRHICTHKPRSLETRVGGRMSVLTPASNTAHFN

--------------------------------------------------------------
>55642_55642_6_MTF2-BRDT_MTF2_chr1_93545088_ENST00000370303_BRDT_chr1_92470676_ENST00000362005_length(transcript)=618nt_BP=221nt
GCTGTATTGAAGTGGGCTGTGTTTGAGGCCGGTGTAAGAACGCTCATTCTACCCCCAACCCTTGTCTCCAAGGACCTCGGTTTGTGCGTG
CATATGTGCCGGGTACCCGGTGGGGCGGGTGCCCAGTAAGTGCTCGGACTCGCAGGGGAAGCGCCCACGGGGACGGATTGGTTGTTTTTT
CCTGTATGAAGCGGTTGGCACCACTGAAGTGACCGAATGAGGGATCTTGGGAATGGATTGACTGTAGAATCTTTTTCAAATAAAATACAA
AACAAGTGCTCTGGAGAAGAGCAGAAAGAACATCAGCAGTCATCAGAAGCTCAAGATAAATCCAAACTCTGGCTTCTCAAAGACCGTGAT
TTAGCAAGGCAGAAAGAACAAGAGAGGAGGAGGAGAGAAGCAATGGTGGGTACCATTGATATGACCCTTCAAAGTGACATTATGACAATG
TTTGAAAACAACTTTGATTAAAACTCAGTTTTTAAATTAACCATCAACTTAAAATGAATGGTAAAAGATCAAAATGCATATGGTAAAATG

>55642_55642_6_MTF2-BRDT_MTF2_chr1_93545088_ENST00000370303_BRDT_chr1_92470676_ENST00000362005_length(amino acids)=91AA_BP=1
MFCILFEKDSTVNPFPRSLIRSLQWCQPLHTGKNNQSVPVGASPASPSTYWAPAPPGTRHICTHKPRSLETRVGGRMSVLTPASNTAHFN

--------------------------------------------------------------
>55642_55642_7_MTF2-BRDT_MTF2_chr1_93545088_ENST00000370303_BRDT_chr1_92470676_ENST00000370389_length(transcript)=618nt_BP=221nt
GCTGTATTGAAGTGGGCTGTGTTTGAGGCCGGTGTAAGAACGCTCATTCTACCCCCAACCCTTGTCTCCAAGGACCTCGGTTTGTGCGTG
CATATGTGCCGGGTACCCGGTGGGGCGGGTGCCCAGTAAGTGCTCGGACTCGCAGGGGAAGCGCCCACGGGGACGGATTGGTTGTTTTTT
CCTGTATGAAGCGGTTGGCACCACTGAAGTGACCGAATGAGGGATCTTGGGAATGGATTGACTGTAGAATCTTTTTCAAATAAAATACAA
AACAAGTGCTCTGGAGAAGAGCAGAAAGAACATCAGCAGTCATCAGAAGCTCAAGATAAATCCAAACTCTGGCTTCTCAAAGACCGTGAT
TTAGCAAGGCAGAAAGAACAAGAGAGGAGGAGGAGAGAAGCAATGGTGGGTACCATTGATATGACCCTTCAAAGTGACATTATGACAATG
TTTGAAAACAACTTTGATTAAAACTCAGTTTTTAAATTAACCATCAACTTAAAATGAATGGTAAAAGATCAAAATGCATATGGTAAAATG

>55642_55642_7_MTF2-BRDT_MTF2_chr1_93545088_ENST00000370303_BRDT_chr1_92470676_ENST00000370389_length(amino acids)=91AA_BP=1
MFCILFEKDSTVNPFPRSLIRSLQWCQPLHTGKNNQSVPVGASPASPSTYWAPAPPGTRHICTHKPRSLETRVGGRMSVLTPASNTAHFN

--------------------------------------------------------------
>55642_55642_8_MTF2-BRDT_MTF2_chr1_93545088_ENST00000370303_BRDT_chr1_92470676_ENST00000394530_length(transcript)=615nt_BP=221nt
GCTGTATTGAAGTGGGCTGTGTTTGAGGCCGGTGTAAGAACGCTCATTCTACCCCCAACCCTTGTCTCCAAGGACCTCGGTTTGTGCGTG
CATATGTGCCGGGTACCCGGTGGGGCGGGTGCCCAGTAAGTGCTCGGACTCGCAGGGGAAGCGCCCACGGGGACGGATTGGTTGTTTTTT
CCTGTATGAAGCGGTTGGCACCACTGAAGTGACCGAATGAGGGATCTTGGGAATGGATTGACTGTAGAATCTTTTTCAAATAAAATACAA
AACAAGTGCTCTGGAGAAGAGCAGAAAGAACATCAGCAGTCATCAGAAGCTCAAGATAAATCCAAACTCTGGCTTCTCAAAGACCGTGAT
TTAGCAAGGCAGAAAGAACAAGAGAGGAGGAGGAGAGAAGCAATGGTGGGTACCATTGATATGACCCTTCAAAGTGACATTATGACAATG
TTTGAAAACAACTTTGATTAAAACTCAGTTTTTAAATTAACCATCAACTTAAAATGAATGGTAAAAGATCAAAATGCATATGGTAAAATG

>55642_55642_8_MTF2-BRDT_MTF2_chr1_93545088_ENST00000370303_BRDT_chr1_92470676_ENST00000394530_length(amino acids)=91AA_BP=1
MFCILFEKDSTVNPFPRSLIRSLQWCQPLHTGKNNQSVPVGASPASPSTYWAPAPPGTRHICTHKPRSLETRVGGRMSVLTPASNTAHFN

--------------------------------------------------------------
>55642_55642_9_MTF2-BRDT_MTF2_chr1_93545088_ENST00000370303_BRDT_chr1_92470676_ENST00000399546_length(transcript)=623nt_BP=221nt
GCTGTATTGAAGTGGGCTGTGTTTGAGGCCGGTGTAAGAACGCTCATTCTACCCCCAACCCTTGTCTCCAAGGACCTCGGTTTGTGCGTG
CATATGTGCCGGGTACCCGGTGGGGCGGGTGCCCAGTAAGTGCTCGGACTCGCAGGGGAAGCGCCCACGGGGACGGATTGGTTGTTTTTT
CCTGTATGAAGCGGTTGGCACCACTGAAGTGACCGAATGAGGGATCTTGGGAATGGATTGACTGTAGAATCTTTTTCAAATAAAATACAA
AACAAGTGCTCTGGAGAAGAGCAGAAAGAACATCAGCAGTCATCAGAAGCTCAAGATAAATCCAAACTCTGGCTTCTCAAAGACCGTGAT
TTAGCAAGGCAGAAAGAACAAGAGAGGAGGAGGAGAGAAGCAATGGTGGGTACCATTGATATGACCCTTCAAAGTGACATTATGACAATG
TTTGAAAACAACTTTGATTAAAACTCAGTTTTTAAATTAACCATCAACTTAAAATGAATGGTAAAAGATCAAAATGCATATGGTAAAATG

>55642_55642_9_MTF2-BRDT_MTF2_chr1_93545088_ENST00000370303_BRDT_chr1_92470676_ENST00000399546_length(amino acids)=91AA_BP=1
MFCILFEKDSTVNPFPRSLIRSLQWCQPLHTGKNNQSVPVGASPASPSTYWAPAPPGTRHICTHKPRSLETRVGGRMSVLTPASNTAHFN

--------------------------------------------------------------
>55642_55642_10_MTF2-BRDT_MTF2_chr1_93545088_ENST00000370303_BRDT_chr1_92470676_ENST00000402388_length(transcript)=618nt_BP=221nt
GCTGTATTGAAGTGGGCTGTGTTTGAGGCCGGTGTAAGAACGCTCATTCTACCCCCAACCCTTGTCTCCAAGGACCTCGGTTTGTGCGTG
CATATGTGCCGGGTACCCGGTGGGGCGGGTGCCCAGTAAGTGCTCGGACTCGCAGGGGAAGCGCCCACGGGGACGGATTGGTTGTTTTTT
CCTGTATGAAGCGGTTGGCACCACTGAAGTGACCGAATGAGGGATCTTGGGAATGGATTGACTGTAGAATCTTTTTCAAATAAAATACAA
AACAAGTGCTCTGGAGAAGAGCAGAAAGAACATCAGCAGTCATCAGAAGCTCAAGATAAATCCAAACTCTGGCTTCTCAAAGACCGTGAT
TTAGCAAGGCAGAAAGAACAAGAGAGGAGGAGGAGAGAAGCAATGGTGGGTACCATTGATATGACCCTTCAAAGTGACATTATGACAATG
TTTGAAAACAACTTTGATTAAAACTCAGTTTTTAAATTAACCATCAACTTAAAATGAATGGTAAAAGATCAAAATGCATATGGTAAAATG

>55642_55642_10_MTF2-BRDT_MTF2_chr1_93545088_ENST00000370303_BRDT_chr1_92470676_ENST00000402388_length(amino acids)=91AA_BP=1
MFCILFEKDSTVNPFPRSLIRSLQWCQPLHTGKNNQSVPVGASPASPSTYWAPAPPGTRHICTHKPRSLETRVGGRMSVLTPASNTAHFN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MTF2-BRDT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MTF2-BRDT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MTF2-BRDT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource