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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MTFR1-LIG1 (FusionGDB2 ID:55656)

Fusion Gene Summary for MTFR1-LIG1

check button Fusion gene summary
Fusion gene informationFusion gene name: MTFR1-LIG1
Fusion gene ID: 55656
HgeneTgene
Gene symbol

MTFR1

LIG1

Gene ID

9650

26018

Gene namemitochondrial fission regulator 1leucine rich repeats and immunoglobulin like domains 1
SynonymsCHPPR|FAM54A2LIG-1|LIG1
Cytomap

8q13.1

3p14.1

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial fission regulator 1chondrocyte protein with a poly-proline regionleucine-rich repeats and immunoglobulin-like domains protein 1leucine-rich repeat protein LRIG1ortholog of mouse integral membrane glycoprotein LIG-1
Modification date2020032020200320
UniProtAcc

Q15390

P18858

Ensembl transtripts involved in fusion geneENST00000517944, ENST00000262146, 
ENST00000458689, 		ENST00000263274, 
ENST00000427526, ENST00000536218, 
ENST00000599165, 
Fusion gene scores* DoF score5 X 5 X 4=1006 X 6 X 5=180
# samples 56
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MTFR1 [Title/Abstract] AND LIG1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMTFR1(66605994)-LIG1(48647220), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MTFR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LIG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-X6-A8C2-01AMTFR1chr8

66605994

-LIG1chr19

48647220

-
ChimerDB4SARCTCGA-X6-A8C2-01AMTFR1chr8

66605994

+LIG1chr19

48647220

-


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Fusion Gene ORF analysis for MTFR1-LIG1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000517944ENST00000263274MTFR1chr8

66605994

+LIG1chr19

48647220

-
3UTR-3CDSENST00000517944ENST00000427526MTFR1chr8

66605994

+LIG1chr19

48647220

-
3UTR-3CDSENST00000517944ENST00000536218MTFR1chr8

66605994

+LIG1chr19

48647220

-
3UTR-intronENST00000517944ENST00000599165MTFR1chr8

66605994

+LIG1chr19

48647220

-
5CDS-intronENST00000262146ENST00000599165MTFR1chr8

66605994

+LIG1chr19

48647220

-
5CDS-intronENST00000458689ENST00000599165MTFR1chr8

66605994

+LIG1chr19

48647220

-
In-frameENST00000262146ENST00000263274MTFR1chr8

66605994

+LIG1chr19

48647220

-
In-frameENST00000262146ENST00000427526MTFR1chr8

66605994

+LIG1chr19

48647220

-
In-frameENST00000262146ENST00000536218MTFR1chr8

66605994

+LIG1chr19

48647220

-
In-frameENST00000458689ENST00000263274MTFR1chr8

66605994

+LIG1chr19

48647220

-
In-frameENST00000458689ENST00000427526MTFR1chr8

66605994

+LIG1chr19

48647220

-
In-frameENST00000458689ENST00000536218MTFR1chr8

66605994

+LIG1chr19

48647220

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262146MTFR1chr866605994+ENST00000263274LIG1chr1948647220-25954071262390754
ENST00000262146MTFR1chr866605994+ENST00000536218LIG1chr1948647220-25904071262390754
ENST00000262146MTFR1chr866605994+ENST00000427526LIG1chr1948647220-25904071262390754
ENST00000458689MTFR1chr866605994+ENST00000263274LIG1chr1948647220-2450262802245721
ENST00000458689MTFR1chr866605994+ENST00000536218LIG1chr1948647220-2445262802245721
ENST00000458689MTFR1chr866605994+ENST00000427526LIG1chr1948647220-2445262802245721

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262146ENST00000263274MTFR1chr866605994+LIG1chr1948647220-0.0057866380.9942134
ENST00000262146ENST00000536218MTFR1chr866605994+LIG1chr1948647220-0.0057604240.99423957
ENST00000262146ENST00000427526MTFR1chr866605994+LIG1chr1948647220-0.0057604240.99423957
ENST00000458689ENST00000263274MTFR1chr866605994+LIG1chr1948647220-0.0090252210.9909747
ENST00000458689ENST00000536218MTFR1chr866605994+LIG1chr1948647220-0.0089751420.99102485
ENST00000458689ENST00000427526MTFR1chr866605994+LIG1chr1948647220-0.0089751420.99102485

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Fusion Genomic Features for MTFR1-LIG1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MTFR1-LIG1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:66605994/chr19:48647220)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTFR1

Q15390

LIG1

P18858

FUNCTION: May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity). {ECO:0000250}.FUNCTION: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTFR1chr8:66605994chr19:48647220ENST00000262146+48137_16993334.0Coiled coilOntology_term=ECO:0000255
HgeneMTFR1chr8:66605994chr19:48647220ENST00000458689+26137_16960301.0Coiled coilOntology_term=ECO:0000255
HgeneMTFR1chr8:66605994chr19:48647220ENST00000262146+48184_19793334.0Compositional biasNote=Pro-rich
HgeneMTFR1chr8:66605994chr19:48647220ENST00000458689+26184_19760301.0Compositional biasNote=Pro-rich
HgeneMTFR1chr8:66605994chr19:48647220ENST00000262146+48179_30493334.0RegionNecessary and sufficient to promote mitochondrial fission
HgeneMTFR1chr8:66605994chr19:48647220ENST00000458689+26179_30460301.0RegionNecessary and sufficient to promote mitochondrial fission


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Fusion Gene Sequence for MTFR1-LIG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>55656_55656_1_MTFR1-LIG1_MTFR1_chr8_66605994_ENST00000262146_LIG1_chr19_48647220_ENST00000263274_length(transcript)=2595nt_BP=407nt
AGAAGCCTGAGGAGCCGGAGAGGGTGCTGGCTGCCGCGCGGCCGAGTGTGTTTTATGGACCATGTGCTGCTATGTATGCCTGAAGAAGTA
CTTGAAATGCAAATTTGGGGAGACTTTGCCATATAAATGCTTGGCTGGATTAAGCGCCTAATTAGGATGGTTTTTCAACAAGTTGGAGTA
AGCATGCAATCGGTACTTTGGTCTAGGAAGCCATATGGTTCGTCTCGAAGTATCGTAAGGAAAATTGGTACTAATTTGTCTCTGATTCAG
TGTCCAAGAGTTCAGTTTCAGATTAACAGCCATGCAACAGAATGGAGTCCCAGCCACCCAGGAGAGGATGCAGTGGCGTCTTTTGCTGAT
GTTGGATGGGTAGCCAAAGAAGAAGGAGAGTGTTCAGCAAGACTAAGACCCCTGGATCCATCTGGTTACAATCCTGCCAAGAACAACTAT
CATCCCGTGGAAGATGCCTGCTGGAAACCGGGCCAGAAGGTTCCTTACCTGGCTGTGGCCCGGACGTTTGAGAAGATCGAGGAGGTGTCT
GCTCGGCTCCGGATGGTGGAGACGCTGAGCAACTTGCTGCGCTCCGTGGTGGCCCTGTCGCCTCCAGACCTCCTCCCTGTCCTCTACCTC
AGCCTCAACCACCTTGGGCCACCCCAGCAGGGCCTGGAGCTTGGCGTGGGTGATGGTGTCCTTCTCAAGGCAGTGGCCCAGGCCACAGGT
CGGCAGCTGGAGTCCGTCCGGGCTGAGGCAGCCGAGAAAGGCGACGTGGGGCTGGTGGCCGAGAACAGCCGCAGCACCCAGAGGCTCATG
CTGCCACCACCTCCGCTCACTGCCTCCGGGGTCTTCAGCAAGTTCCGCGACATCGCCAGGCTCACTGGCAGTGCTTCCACAGCCAAGAAG
ATAGACATCATCAAAGGCCTCTTTGTGGCCTGCCGCCACTCAGAAGCCCGGTTCATCGCTAGGTCCCTGAGCGGACGGCTGCGCCTTGGG
CTGGCAGAGCAGTCGGTGCTGGCTGCCCTCTCCCAGGCAGTGAGCCTCACGCCCCCGGGCCAAGAATTCCCACCAGCCATGGTGGATGCT
GGGAAGGGCAAGACAGCAGAGGCCAGAAAGACGTGGCTGGAGGAGCAAGGCATGATCCTGAAGCAGACGTTCTGCGAGGTTCCCGACCTG
GACCGAATTATCCCCGTGCTGCTGGAGCACGGCCTGGAACGTCTCCCGGAGCACTGCAAGCTGAGCCCAGGGATTCCCCTGAAACCAATG
TTGGCCCATCCCACCCGGGGCATCAGCGAGGTCCTGAAACGCTTTGAGGAGGCAGCTTTCACCTGCGAATACAAATATGACGGGCAGAGG
GCACAGATCCACGCCCTGGAAGGCGGGGAGGTGAAGATCTTCAGCAGGAATCAGGAAGACAACACTGGGAAGTACCCGGACATCATCAGC
CGCATCCCCAAGATTAAACTCCCATCGGTCACATCCTTCATCCTGGACACCGAAGCCGTGGCTTGGGACCGGGAAAAGAAGCAGATCCAG
CCATTCCAAGTGCTCACCACCCGCAAACGCAAGGAGGTGGATGCGTCTGAGATCCAGGTGCAGGTGTGTTTGTACGCCTTCGACCTCATC
TACCTCAATGGAGAGTCCCTGGTACGTGAGCCCCTTTCCCGGCGCCGGCAGCTGCTCCGGGAGAACTTTGTGGAGACAGAGGGCGAGTTT
GTCTTCGCCACCTCCCTGGACACCAAGGACATCGAGCAGATCGCCGAGTTCCTGGAGCAGTCAGTGAAAGACTCCTGCGAGGGGCTGATG
GTGAAGACCCTGGATGTTGATGCCACCTACGAGATCGCCAAGAGATCGCACAACTGGCTCAAGCTGAAGAAGGACTACCTTGATGGCGTG
GGTGACACCCTGGACCTGGTGGTGATCGGCGCCTACCTGGGCCGGGGGAAGCGGGCCGGCCGGTACGGGGGCTTCCTGCTGGCCTCCTAC
GACGAGGACAGTGAGGAGCTGCAGGCCATATGCAAGCTTGGAACTGGCTTCAGTGATGAGGAGCTGGAGGAGCATCACCAGAGCCTCAAG
GCGCTGGTGCTGCCCAGCCCACGCCCTTACGTGCGGATAGATGGCGCTGTGATTCCCGACCACTGGCTGGACCCCAGCGCTGTGTGGGAG
GTGAAGTGCGCTGACCTCTCCCTCTCTCCCATCTACCCTGCTGCGCGGGGCCTGGTGGATAGTGACAAGGGCATCTCCCTTCGCTTCCCT
CGGTTTATTCGAGTCCGTGAAGACAAGCAGCCGGAGCAGGCCACCACCAGTGCTCAGGTGGCCTGTTTGTACCGGAAGCAAAGTCAGATT
CAGAACCAACAAGGCGAGGACTCAGGCTCTGACCCTGAAGATACCTACTAAGCCCTCGCCCTCCTAGGGCCTGGGTACAGGGCATGAGTT
GGACGGACCCCAGGGTTATTATTGCCTTTGCTTTTTAGCAAATCTGCTGTGGCAGGCTGTGGATTTTGAGAGTCAGGGGAGGGGTGTGTG

>55656_55656_1_MTFR1-LIG1_MTFR1_chr8_66605994_ENST00000262146_LIG1_chr19_48647220_ENST00000263274_length(amino acids)=754AA_BP=93
MLGWIKRLIRMVFQQVGVSMQSVLWSRKPYGSSRSIVRKIGTNLSLIQCPRVQFQINSHATEWSPSHPGEDAVASFADVGWVAKEEGECS
ARLRPLDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGL
ELGVGDGVLLKAVAQATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIARLTGSASTAKKIDIIKGLFVACR
HSEARFIARSLSGRLRLGLAEQSVLAALSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGL
ERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLPSVTS
FILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIE
QIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLLASYDEDSEELQAICK
LGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPE

--------------------------------------------------------------
>55656_55656_2_MTFR1-LIG1_MTFR1_chr8_66605994_ENST00000262146_LIG1_chr19_48647220_ENST00000427526_length(transcript)=2590nt_BP=407nt
AGAAGCCTGAGGAGCCGGAGAGGGTGCTGGCTGCCGCGCGGCCGAGTGTGTTTTATGGACCATGTGCTGCTATGTATGCCTGAAGAAGTA
CTTGAAATGCAAATTTGGGGAGACTTTGCCATATAAATGCTTGGCTGGATTAAGCGCCTAATTAGGATGGTTTTTCAACAAGTTGGAGTA
AGCATGCAATCGGTACTTTGGTCTAGGAAGCCATATGGTTCGTCTCGAAGTATCGTAAGGAAAATTGGTACTAATTTGTCTCTGATTCAG
TGTCCAAGAGTTCAGTTTCAGATTAACAGCCATGCAACAGAATGGAGTCCCAGCCACCCAGGAGAGGATGCAGTGGCGTCTTTTGCTGAT
GTTGGATGGGTAGCCAAAGAAGAAGGAGAGTGTTCAGCAAGACTAAGACCCCTGGATCCATCTGGTTACAATCCTGCCAAGAACAACTAT
CATCCCGTGGAAGATGCCTGCTGGAAACCGGGCCAGAAGGTTCCTTACCTGGCTGTGGCCCGGACGTTTGAGAAGATCGAGGAGGTGTCT
GCTCGGCTCCGGATGGTGGAGACGCTGAGCAACTTGCTGCGCTCCGTGGTGGCCCTGTCGCCTCCAGACCTCCTCCCTGTCCTCTACCTC
AGCCTCAACCACCTTGGGCCACCCCAGCAGGGCCTGGAGCTTGGCGTGGGTGATGGTGTCCTTCTCAAGGCAGTGGCCCAGGCCACAGGT
CGGCAGCTGGAGTCCGTCCGGGCTGAGGCAGCCGAGAAAGGCGACGTGGGGCTGGTGGCCGAGAACAGCCGCAGCACCCAGAGGCTCATG
CTGCCACCACCTCCGCTCACTGCCTCCGGGGTCTTCAGCAAGTTCCGCGACATCGCCAGGCTCACTGGCAGTGCTTCCACAGCCAAGAAG
ATAGACATCATCAAAGGCCTCTTTGTGGCCTGCCGCCACTCAGAAGCCCGGTTCATCGCTAGGTCCCTGAGCGGACGGCTGCGCCTTGGG
CTGGCAGAGCAGTCGGTGCTGGCTGCCCTCTCCCAGGCAGTGAGCCTCACGCCCCCGGGCCAAGAATTCCCACCAGCCATGGTGGATGCT
GGGAAGGGCAAGACAGCAGAGGCCAGAAAGACGTGGCTGGAGGAGCAAGGCATGATCCTGAAGCAGACGTTCTGCGAGGTTCCCGACCTG
GACCGAATTATCCCCGTGCTGCTGGAGCACGGCCTGGAACGTCTCCCGGAGCACTGCAAGCTGAGCCCAGGGATTCCCCTGAAACCAATG
TTGGCCCATCCCACCCGGGGCATCAGCGAGGTCCTGAAACGCTTTGAGGAGGCAGCTTTCACCTGCGAATACAAATATGACGGGCAGAGG
GCACAGATCCACGCCCTGGAAGGCGGGGAGGTGAAGATCTTCAGCAGGAATCAGGAAGACAACACTGGGAAGTACCCGGACATCATCAGC
CGCATCCCCAAGATTAAACTCCCATCGGTCACATCCTTCATCCTGGACACCGAAGCCGTGGCTTGGGACCGGGAAAAGAAGCAGATCCAG
CCATTCCAAGTGCTCACCACCCGCAAACGCAAGGAGGTGGATGCGTCTGAGATCCAGGTGCAGGTGTGTTTGTACGCCTTCGACCTCATC
TACCTCAATGGAGAGTCCCTGGTACGTGAGCCCCTTTCCCGGCGCCGGCAGCTGCTCCGGGAGAACTTTGTGGAGACAGAGGGCGAGTTT
GTCTTCGCCACCTCCCTGGACACCAAGGACATCGAGCAGATCGCCGAGTTCCTGGAGCAGTCAGTGAAAGACTCCTGCGAGGGGCTGATG
GTGAAGACCCTGGATGTTGATGCCACCTACGAGATCGCCAAGAGATCGCACAACTGGCTCAAGCTGAAGAAGGACTACCTTGATGGCGTG
GGTGACACCCTGGACCTGGTGGTGATCGGCGCCTACCTGGGCCGGGGGAAGCGGGCCGGCCGGTACGGGGGCTTCCTGCTGGCCTCCTAC
GACGAGGACAGTGAGGAGCTGCAGGCCATATGCAAGCTTGGAACTGGCTTCAGTGATGAGGAGCTGGAGGAGCATCACCAGAGCCTCAAG
GCGCTGGTGCTGCCCAGCCCACGCCCTTACGTGCGGATAGATGGCGCTGTGATTCCCGACCACTGGCTGGACCCCAGCGCTGTGTGGGAG
GTGAAGTGCGCTGACCTCTCCCTCTCTCCCATCTACCCTGCTGCGCGGGGCCTGGTGGATAGTGACAAGGGCATCTCCCTTCGCTTCCCT
CGGTTTATTCGAGTCCGTGAAGACAAGCAGCCGGAGCAGGCCACCACCAGTGCTCAGGTGGCCTGTTTGTACCGGAAGCAAAGTCAGATT
CAGAACCAACAAGGCGAGGACTCAGGCTCTGACCCTGAAGATACCTACTAAGCCCTCGCCCTCCTAGGGCCTGGGTACAGGGCATGAGTT
GGACGGACCCCAGGGTTATTATTGCCTTTGCTTTTTAGCAAATCTGCTGTGGCAGGCTGTGGATTTTGAGAGTCAGGGGAGGGGTGTGTG

>55656_55656_2_MTFR1-LIG1_MTFR1_chr8_66605994_ENST00000262146_LIG1_chr19_48647220_ENST00000427526_length(amino acids)=754AA_BP=93
MLGWIKRLIRMVFQQVGVSMQSVLWSRKPYGSSRSIVRKIGTNLSLIQCPRVQFQINSHATEWSPSHPGEDAVASFADVGWVAKEEGECS
ARLRPLDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGL
ELGVGDGVLLKAVAQATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIARLTGSASTAKKIDIIKGLFVACR
HSEARFIARSLSGRLRLGLAEQSVLAALSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGL
ERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLPSVTS
FILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIE
QIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLLASYDEDSEELQAICK
LGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPE

--------------------------------------------------------------
>55656_55656_3_MTFR1-LIG1_MTFR1_chr8_66605994_ENST00000262146_LIG1_chr19_48647220_ENST00000536218_length(transcript)=2590nt_BP=407nt
AGAAGCCTGAGGAGCCGGAGAGGGTGCTGGCTGCCGCGCGGCCGAGTGTGTTTTATGGACCATGTGCTGCTATGTATGCCTGAAGAAGTA
CTTGAAATGCAAATTTGGGGAGACTTTGCCATATAAATGCTTGGCTGGATTAAGCGCCTAATTAGGATGGTTTTTCAACAAGTTGGAGTA
AGCATGCAATCGGTACTTTGGTCTAGGAAGCCATATGGTTCGTCTCGAAGTATCGTAAGGAAAATTGGTACTAATTTGTCTCTGATTCAG
TGTCCAAGAGTTCAGTTTCAGATTAACAGCCATGCAACAGAATGGAGTCCCAGCCACCCAGGAGAGGATGCAGTGGCGTCTTTTGCTGAT
GTTGGATGGGTAGCCAAAGAAGAAGGAGAGTGTTCAGCAAGACTAAGACCCCTGGATCCATCTGGTTACAATCCTGCCAAGAACAACTAT
CATCCCGTGGAAGATGCCTGCTGGAAACCGGGCCAGAAGGTTCCTTACCTGGCTGTGGCCCGGACGTTTGAGAAGATCGAGGAGGTGTCT
GCTCGGCTCCGGATGGTGGAGACGCTGAGCAACTTGCTGCGCTCCGTGGTGGCCCTGTCGCCTCCAGACCTCCTCCCTGTCCTCTACCTC
AGCCTCAACCACCTTGGGCCACCCCAGCAGGGCCTGGAGCTTGGCGTGGGTGATGGTGTCCTTCTCAAGGCAGTGGCCCAGGCCACAGGT
CGGCAGCTGGAGTCCGTCCGGGCTGAGGCAGCCGAGAAAGGCGACGTGGGGCTGGTGGCCGAGAACAGCCGCAGCACCCAGAGGCTCATG
CTGCCACCACCTCCGCTCACTGCCTCCGGGGTCTTCAGCAAGTTCCGCGACATCGCCAGGCTCACTGGCAGTGCTTCCACAGCCAAGAAG
ATAGACATCATCAAAGGCCTCTTTGTGGCCTGCCGCCACTCAGAAGCCCGGTTCATCGCTAGGTCCCTGAGCGGACGGCTGCGCCTTGGG
CTGGCAGAGCAGTCGGTGCTGGCTGCCCTCTCCCAGGCAGTGAGCCTCACGCCCCCGGGCCAAGAATTCCCACCAGCCATGGTGGATGCT
GGGAAGGGCAAGACAGCAGAGGCCAGAAAGACGTGGCTGGAGGAGCAAGGCATGATCCTGAAGCAGACGTTCTGCGAGGTTCCCGACCTG
GACCGAATTATCCCCGTGCTGCTGGAGCACGGCCTGGAACGTCTCCCGGAGCACTGCAAGCTGAGCCCAGGGATTCCCCTGAAACCAATG
TTGGCCCATCCCACCCGGGGCATCAGCGAGGTCCTGAAACGCTTTGAGGAGGCAGCTTTCACCTGCGAATACAAATATGACGGGCAGAGG
GCACAGATCCACGCCCTGGAAGGCGGGGAGGTGAAGATCTTCAGCAGGAATCAGGAAGACAACACTGGGAAGTACCCGGACATCATCAGC
CGCATCCCCAAGATTAAACTCCCATCGGTCACATCCTTCATCCTGGACACCGAAGCCGTGGCTTGGGACCGGGAAAAGAAGCAGATCCAG
CCATTCCAAGTGCTCACCACCCGCAAACGCAAGGAGGTGGATGCGTCTGAGATCCAGGTGCAGGTGTGTTTGTACGCCTTCGACCTCATC
TACCTCAATGGAGAGTCCCTGGTACGTGAGCCCCTTTCCCGGCGCCGGCAGCTGCTCCGGGAGAACTTTGTGGAGACAGAGGGCGAGTTT
GTCTTCGCCACCTCCCTGGACACCAAGGACATCGAGCAGATCGCCGAGTTCCTGGAGCAGTCAGTGAAAGACTCCTGCGAGGGGCTGATG
GTGAAGACCCTGGATGTTGATGCCACCTACGAGATCGCCAAGAGATCGCACAACTGGCTCAAGCTGAAGAAGGACTACCTTGATGGCGTG
GGTGACACCCTGGACCTGGTGGTGATCGGCGCCTACCTGGGCCGGGGGAAGCGGGCCGGCCGGTACGGGGGCTTCCTGCTGGCCTCCTAC
GACGAGGACAGTGAGGAGCTGCAGGCCATATGCAAGCTTGGAACTGGCTTCAGTGATGAGGAGCTGGAGGAGCATCACCAGAGCCTCAAG
GCGCTGGTGCTGCCCAGCCCACGCCCTTACGTGCGGATAGATGGCGCTGTGATTCCCGACCACTGGCTGGACCCCAGCGCTGTGTGGGAG
GTGAAGTGCGCTGACCTCTCCCTCTCTCCCATCTACCCTGCTGCGCGGGGCCTGGTGGATAGTGACAAGGGCATCTCCCTTCGCTTCCCT
CGGTTTATTCGAGTCCGTGAAGACAAGCAGCCGGAGCAGGCCACCACCAGTGCTCAGGTGGCCTGTTTGTACCGGAAGCAAAGTCAGATT
CAGAACCAACAAGGCGAGGACTCAGGCTCTGACCCTGAAGATACCTACTAAGCCCTCGCCCTCCTAGGGCCTGGGTACAGGGCATGAGTT
GGACGGACCCCAGGGTTATTATTGCCTTTGCTTTTTAGCAAATCTGCTGTGGCAGGCTGTGGATTTTGAGAGTCAGGGGAGGGGTGTGTG

>55656_55656_3_MTFR1-LIG1_MTFR1_chr8_66605994_ENST00000262146_LIG1_chr19_48647220_ENST00000536218_length(amino acids)=754AA_BP=93
MLGWIKRLIRMVFQQVGVSMQSVLWSRKPYGSSRSIVRKIGTNLSLIQCPRVQFQINSHATEWSPSHPGEDAVASFADVGWVAKEEGECS
ARLRPLDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGL
ELGVGDGVLLKAVAQATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIARLTGSASTAKKIDIIKGLFVACR
HSEARFIARSLSGRLRLGLAEQSVLAALSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGL
ERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLPSVTS
FILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIE
QIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLLASYDEDSEELQAICK
LGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPE

--------------------------------------------------------------
>55656_55656_4_MTFR1-LIG1_MTFR1_chr8_66605994_ENST00000458689_LIG1_chr19_48647220_ENST00000263274_length(transcript)=2450nt_BP=262nt
TGTGTTTTATGGACCATGTGCTGCTATGTATGCCTGAAGAAGTACTTGAAATGCAAATTTGGGGAGACTTTGCCATATAAATGCTTGGCT
GGATTAAGCGCCTAATTAGGATGGTTTTTCAACAAGTTGGAGTAAGCATGCAATCGATTAACAGCCATGCAACAGAATGGAGTCCCAGCC
ACCCAGGAGAGGATGCAGTGGCGTCTTTTGCTGATGTTGGATGGGTAGCCAAAGAAGAAGGAGAGTGTTCAGCAAGACTAAGACCCCTGG
ATCCATCTGGTTACAATCCTGCCAAGAACAACTATCATCCCGTGGAAGATGCCTGCTGGAAACCGGGCCAGAAGGTTCCTTACCTGGCTG
TGGCCCGGACGTTTGAGAAGATCGAGGAGGTGTCTGCTCGGCTCCGGATGGTGGAGACGCTGAGCAACTTGCTGCGCTCCGTGGTGGCCC
TGTCGCCTCCAGACCTCCTCCCTGTCCTCTACCTCAGCCTCAACCACCTTGGGCCACCCCAGCAGGGCCTGGAGCTTGGCGTGGGTGATG
GTGTCCTTCTCAAGGCAGTGGCCCAGGCCACAGGTCGGCAGCTGGAGTCCGTCCGGGCTGAGGCAGCCGAGAAAGGCGACGTGGGGCTGG
TGGCCGAGAACAGCCGCAGCACCCAGAGGCTCATGCTGCCACCACCTCCGCTCACTGCCTCCGGGGTCTTCAGCAAGTTCCGCGACATCG
CCAGGCTCACTGGCAGTGCTTCCACAGCCAAGAAGATAGACATCATCAAAGGCCTCTTTGTGGCCTGCCGCCACTCAGAAGCCCGGTTCA
TCGCTAGGTCCCTGAGCGGACGGCTGCGCCTTGGGCTGGCAGAGCAGTCGGTGCTGGCTGCCCTCTCCCAGGCAGTGAGCCTCACGCCCC
CGGGCCAAGAATTCCCACCAGCCATGGTGGATGCTGGGAAGGGCAAGACAGCAGAGGCCAGAAAGACGTGGCTGGAGGAGCAAGGCATGA
TCCTGAAGCAGACGTTCTGCGAGGTTCCCGACCTGGACCGAATTATCCCCGTGCTGCTGGAGCACGGCCTGGAACGTCTCCCGGAGCACT
GCAAGCTGAGCCCAGGGATTCCCCTGAAACCAATGTTGGCCCATCCCACCCGGGGCATCAGCGAGGTCCTGAAACGCTTTGAGGAGGCAG
CTTTCACCTGCGAATACAAATATGACGGGCAGAGGGCACAGATCCACGCCCTGGAAGGCGGGGAGGTGAAGATCTTCAGCAGGAATCAGG
AAGACAACACTGGGAAGTACCCGGACATCATCAGCCGCATCCCCAAGATTAAACTCCCATCGGTCACATCCTTCATCCTGGACACCGAAG
CCGTGGCTTGGGACCGGGAAAAGAAGCAGATCCAGCCATTCCAAGTGCTCACCACCCGCAAACGCAAGGAGGTGGATGCGTCTGAGATCC
AGGTGCAGGTGTGTTTGTACGCCTTCGACCTCATCTACCTCAATGGAGAGTCCCTGGTACGTGAGCCCCTTTCCCGGCGCCGGCAGCTGC
TCCGGGAGAACTTTGTGGAGACAGAGGGCGAGTTTGTCTTCGCCACCTCCCTGGACACCAAGGACATCGAGCAGATCGCCGAGTTCCTGG
AGCAGTCAGTGAAAGACTCCTGCGAGGGGCTGATGGTGAAGACCCTGGATGTTGATGCCACCTACGAGATCGCCAAGAGATCGCACAACT
GGCTCAAGCTGAAGAAGGACTACCTTGATGGCGTGGGTGACACCCTGGACCTGGTGGTGATCGGCGCCTACCTGGGCCGGGGGAAGCGGG
CCGGCCGGTACGGGGGCTTCCTGCTGGCCTCCTACGACGAGGACAGTGAGGAGCTGCAGGCCATATGCAAGCTTGGAACTGGCTTCAGTG
ATGAGGAGCTGGAGGAGCATCACCAGAGCCTCAAGGCGCTGGTGCTGCCCAGCCCACGCCCTTACGTGCGGATAGATGGCGCTGTGATTC
CCGACCACTGGCTGGACCCCAGCGCTGTGTGGGAGGTGAAGTGCGCTGACCTCTCCCTCTCTCCCATCTACCCTGCTGCGCGGGGCCTGG
TGGATAGTGACAAGGGCATCTCCCTTCGCTTCCCTCGGTTTATTCGAGTCCGTGAAGACAAGCAGCCGGAGCAGGCCACCACCAGTGCTC
AGGTGGCCTGTTTGTACCGGAAGCAAAGTCAGATTCAGAACCAACAAGGCGAGGACTCAGGCTCTGACCCTGAAGATACCTACTAAGCCC
TCGCCCTCCTAGGGCCTGGGTACAGGGCATGAGTTGGACGGACCCCAGGGTTATTATTGCCTTTGCTTTTTAGCAAATCTGCTGTGGCAG
GCTGTGGATTTTGAGAGTCAGGGGAGGGGTGTGTGTGTGAGGGGGTGGCTTACTCCGGAGTCTGGGATTCATCCCGTCATTTCTTTCAAT

>55656_55656_4_MTFR1-LIG1_MTFR1_chr8_66605994_ENST00000458689_LIG1_chr19_48647220_ENST00000263274_length(amino acids)=721AA_BP=60
MLGWIKRLIRMVFQQVGVSMQSINSHATEWSPSHPGEDAVASFADVGWVAKEEGECSARLRPLDPSGYNPAKNNYHPVEDACWKPGQKVP
YLAVARTFEKIEEVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQATGRQLESVRAEAAEKGD
VGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVS
LTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRF
EEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDA
SEIQVQVCLYAFDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKR
SHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDG
AVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQSQIQNQQGEDSGSDPEDT

--------------------------------------------------------------
>55656_55656_5_MTFR1-LIG1_MTFR1_chr8_66605994_ENST00000458689_LIG1_chr19_48647220_ENST00000427526_length(transcript)=2445nt_BP=262nt
TGTGTTTTATGGACCATGTGCTGCTATGTATGCCTGAAGAAGTACTTGAAATGCAAATTTGGGGAGACTTTGCCATATAAATGCTTGGCT
GGATTAAGCGCCTAATTAGGATGGTTTTTCAACAAGTTGGAGTAAGCATGCAATCGATTAACAGCCATGCAACAGAATGGAGTCCCAGCC
ACCCAGGAGAGGATGCAGTGGCGTCTTTTGCTGATGTTGGATGGGTAGCCAAAGAAGAAGGAGAGTGTTCAGCAAGACTAAGACCCCTGG
ATCCATCTGGTTACAATCCTGCCAAGAACAACTATCATCCCGTGGAAGATGCCTGCTGGAAACCGGGCCAGAAGGTTCCTTACCTGGCTG
TGGCCCGGACGTTTGAGAAGATCGAGGAGGTGTCTGCTCGGCTCCGGATGGTGGAGACGCTGAGCAACTTGCTGCGCTCCGTGGTGGCCC
TGTCGCCTCCAGACCTCCTCCCTGTCCTCTACCTCAGCCTCAACCACCTTGGGCCACCCCAGCAGGGCCTGGAGCTTGGCGTGGGTGATG
GTGTCCTTCTCAAGGCAGTGGCCCAGGCCACAGGTCGGCAGCTGGAGTCCGTCCGGGCTGAGGCAGCCGAGAAAGGCGACGTGGGGCTGG
TGGCCGAGAACAGCCGCAGCACCCAGAGGCTCATGCTGCCACCACCTCCGCTCACTGCCTCCGGGGTCTTCAGCAAGTTCCGCGACATCG
CCAGGCTCACTGGCAGTGCTTCCACAGCCAAGAAGATAGACATCATCAAAGGCCTCTTTGTGGCCTGCCGCCACTCAGAAGCCCGGTTCA
TCGCTAGGTCCCTGAGCGGACGGCTGCGCCTTGGGCTGGCAGAGCAGTCGGTGCTGGCTGCCCTCTCCCAGGCAGTGAGCCTCACGCCCC
CGGGCCAAGAATTCCCACCAGCCATGGTGGATGCTGGGAAGGGCAAGACAGCAGAGGCCAGAAAGACGTGGCTGGAGGAGCAAGGCATGA
TCCTGAAGCAGACGTTCTGCGAGGTTCCCGACCTGGACCGAATTATCCCCGTGCTGCTGGAGCACGGCCTGGAACGTCTCCCGGAGCACT
GCAAGCTGAGCCCAGGGATTCCCCTGAAACCAATGTTGGCCCATCCCACCCGGGGCATCAGCGAGGTCCTGAAACGCTTTGAGGAGGCAG
CTTTCACCTGCGAATACAAATATGACGGGCAGAGGGCACAGATCCACGCCCTGGAAGGCGGGGAGGTGAAGATCTTCAGCAGGAATCAGG
AAGACAACACTGGGAAGTACCCGGACATCATCAGCCGCATCCCCAAGATTAAACTCCCATCGGTCACATCCTTCATCCTGGACACCGAAG
CCGTGGCTTGGGACCGGGAAAAGAAGCAGATCCAGCCATTCCAAGTGCTCACCACCCGCAAACGCAAGGAGGTGGATGCGTCTGAGATCC
AGGTGCAGGTGTGTTTGTACGCCTTCGACCTCATCTACCTCAATGGAGAGTCCCTGGTACGTGAGCCCCTTTCCCGGCGCCGGCAGCTGC
TCCGGGAGAACTTTGTGGAGACAGAGGGCGAGTTTGTCTTCGCCACCTCCCTGGACACCAAGGACATCGAGCAGATCGCCGAGTTCCTGG
AGCAGTCAGTGAAAGACTCCTGCGAGGGGCTGATGGTGAAGACCCTGGATGTTGATGCCACCTACGAGATCGCCAAGAGATCGCACAACT
GGCTCAAGCTGAAGAAGGACTACCTTGATGGCGTGGGTGACACCCTGGACCTGGTGGTGATCGGCGCCTACCTGGGCCGGGGGAAGCGGG
CCGGCCGGTACGGGGGCTTCCTGCTGGCCTCCTACGACGAGGACAGTGAGGAGCTGCAGGCCATATGCAAGCTTGGAACTGGCTTCAGTG
ATGAGGAGCTGGAGGAGCATCACCAGAGCCTCAAGGCGCTGGTGCTGCCCAGCCCACGCCCTTACGTGCGGATAGATGGCGCTGTGATTC
CCGACCACTGGCTGGACCCCAGCGCTGTGTGGGAGGTGAAGTGCGCTGACCTCTCCCTCTCTCCCATCTACCCTGCTGCGCGGGGCCTGG
TGGATAGTGACAAGGGCATCTCCCTTCGCTTCCCTCGGTTTATTCGAGTCCGTGAAGACAAGCAGCCGGAGCAGGCCACCACCAGTGCTC
AGGTGGCCTGTTTGTACCGGAAGCAAAGTCAGATTCAGAACCAACAAGGCGAGGACTCAGGCTCTGACCCTGAAGATACCTACTAAGCCC
TCGCCCTCCTAGGGCCTGGGTACAGGGCATGAGTTGGACGGACCCCAGGGTTATTATTGCCTTTGCTTTTTAGCAAATCTGCTGTGGCAG
GCTGTGGATTTTGAGAGTCAGGGGAGGGGTGTGTGTGTGAGGGGGTGGCTTACTCCGGAGTCTGGGATTCATCCCGTCATTTCTTTCAAT

>55656_55656_5_MTFR1-LIG1_MTFR1_chr8_66605994_ENST00000458689_LIG1_chr19_48647220_ENST00000427526_length(amino acids)=721AA_BP=60
MLGWIKRLIRMVFQQVGVSMQSINSHATEWSPSHPGEDAVASFADVGWVAKEEGECSARLRPLDPSGYNPAKNNYHPVEDACWKPGQKVP
YLAVARTFEKIEEVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQATGRQLESVRAEAAEKGD
VGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVS
LTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRF
EEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDA
SEIQVQVCLYAFDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKR
SHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDG
AVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQSQIQNQQGEDSGSDPEDT

--------------------------------------------------------------
>55656_55656_6_MTFR1-LIG1_MTFR1_chr8_66605994_ENST00000458689_LIG1_chr19_48647220_ENST00000536218_length(transcript)=2445nt_BP=262nt
TGTGTTTTATGGACCATGTGCTGCTATGTATGCCTGAAGAAGTACTTGAAATGCAAATTTGGGGAGACTTTGCCATATAAATGCTTGGCT
GGATTAAGCGCCTAATTAGGATGGTTTTTCAACAAGTTGGAGTAAGCATGCAATCGATTAACAGCCATGCAACAGAATGGAGTCCCAGCC
ACCCAGGAGAGGATGCAGTGGCGTCTTTTGCTGATGTTGGATGGGTAGCCAAAGAAGAAGGAGAGTGTTCAGCAAGACTAAGACCCCTGG
ATCCATCTGGTTACAATCCTGCCAAGAACAACTATCATCCCGTGGAAGATGCCTGCTGGAAACCGGGCCAGAAGGTTCCTTACCTGGCTG
TGGCCCGGACGTTTGAGAAGATCGAGGAGGTGTCTGCTCGGCTCCGGATGGTGGAGACGCTGAGCAACTTGCTGCGCTCCGTGGTGGCCC
TGTCGCCTCCAGACCTCCTCCCTGTCCTCTACCTCAGCCTCAACCACCTTGGGCCACCCCAGCAGGGCCTGGAGCTTGGCGTGGGTGATG
GTGTCCTTCTCAAGGCAGTGGCCCAGGCCACAGGTCGGCAGCTGGAGTCCGTCCGGGCTGAGGCAGCCGAGAAAGGCGACGTGGGGCTGG
TGGCCGAGAACAGCCGCAGCACCCAGAGGCTCATGCTGCCACCACCTCCGCTCACTGCCTCCGGGGTCTTCAGCAAGTTCCGCGACATCG
CCAGGCTCACTGGCAGTGCTTCCACAGCCAAGAAGATAGACATCATCAAAGGCCTCTTTGTGGCCTGCCGCCACTCAGAAGCCCGGTTCA
TCGCTAGGTCCCTGAGCGGACGGCTGCGCCTTGGGCTGGCAGAGCAGTCGGTGCTGGCTGCCCTCTCCCAGGCAGTGAGCCTCACGCCCC
CGGGCCAAGAATTCCCACCAGCCATGGTGGATGCTGGGAAGGGCAAGACAGCAGAGGCCAGAAAGACGTGGCTGGAGGAGCAAGGCATGA
TCCTGAAGCAGACGTTCTGCGAGGTTCCCGACCTGGACCGAATTATCCCCGTGCTGCTGGAGCACGGCCTGGAACGTCTCCCGGAGCACT
GCAAGCTGAGCCCAGGGATTCCCCTGAAACCAATGTTGGCCCATCCCACCCGGGGCATCAGCGAGGTCCTGAAACGCTTTGAGGAGGCAG
CTTTCACCTGCGAATACAAATATGACGGGCAGAGGGCACAGATCCACGCCCTGGAAGGCGGGGAGGTGAAGATCTTCAGCAGGAATCAGG
AAGACAACACTGGGAAGTACCCGGACATCATCAGCCGCATCCCCAAGATTAAACTCCCATCGGTCACATCCTTCATCCTGGACACCGAAG
CCGTGGCTTGGGACCGGGAAAAGAAGCAGATCCAGCCATTCCAAGTGCTCACCACCCGCAAACGCAAGGAGGTGGATGCGTCTGAGATCC
AGGTGCAGGTGTGTTTGTACGCCTTCGACCTCATCTACCTCAATGGAGAGTCCCTGGTACGTGAGCCCCTTTCCCGGCGCCGGCAGCTGC
TCCGGGAGAACTTTGTGGAGACAGAGGGCGAGTTTGTCTTCGCCACCTCCCTGGACACCAAGGACATCGAGCAGATCGCCGAGTTCCTGG
AGCAGTCAGTGAAAGACTCCTGCGAGGGGCTGATGGTGAAGACCCTGGATGTTGATGCCACCTACGAGATCGCCAAGAGATCGCACAACT
GGCTCAAGCTGAAGAAGGACTACCTTGATGGCGTGGGTGACACCCTGGACCTGGTGGTGATCGGCGCCTACCTGGGCCGGGGGAAGCGGG
CCGGCCGGTACGGGGGCTTCCTGCTGGCCTCCTACGACGAGGACAGTGAGGAGCTGCAGGCCATATGCAAGCTTGGAACTGGCTTCAGTG
ATGAGGAGCTGGAGGAGCATCACCAGAGCCTCAAGGCGCTGGTGCTGCCCAGCCCACGCCCTTACGTGCGGATAGATGGCGCTGTGATTC
CCGACCACTGGCTGGACCCCAGCGCTGTGTGGGAGGTGAAGTGCGCTGACCTCTCCCTCTCTCCCATCTACCCTGCTGCGCGGGGCCTGG
TGGATAGTGACAAGGGCATCTCCCTTCGCTTCCCTCGGTTTATTCGAGTCCGTGAAGACAAGCAGCCGGAGCAGGCCACCACCAGTGCTC
AGGTGGCCTGTTTGTACCGGAAGCAAAGTCAGATTCAGAACCAACAAGGCGAGGACTCAGGCTCTGACCCTGAAGATACCTACTAAGCCC
TCGCCCTCCTAGGGCCTGGGTACAGGGCATGAGTTGGACGGACCCCAGGGTTATTATTGCCTTTGCTTTTTAGCAAATCTGCTGTGGCAG
GCTGTGGATTTTGAGAGTCAGGGGAGGGGTGTGTGTGTGAGGGGGTGGCTTACTCCGGAGTCTGGGATTCATCCCGTCATTTCTTTCAAT

>55656_55656_6_MTFR1-LIG1_MTFR1_chr8_66605994_ENST00000458689_LIG1_chr19_48647220_ENST00000536218_length(amino acids)=721AA_BP=60
MLGWIKRLIRMVFQQVGVSMQSINSHATEWSPSHPGEDAVASFADVGWVAKEEGECSARLRPLDPSGYNPAKNNYHPVEDACWKPGQKVP
YLAVARTFEKIEEVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQATGRQLESVRAEAAEKGD
VGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVS
LTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRF
EEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDA
SEIQVQVCLYAFDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKR
SHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDG
AVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQSQIQNQQGEDSGSDPEDT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MTFR1-LIG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneLIG1chr8:66605994chr19:48647220ENST00000263274828449_458258.6666666666667920.0target DNA
TgeneLIG1chr8:66605994chr19:48647220ENST00000263274828642_644258.6666666666667920.0target DNA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MTFR1-LIG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MTFR1-LIG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource