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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MTG2-AGR2 (FusionGDB2 ID:55671)

Fusion Gene Summary for MTG2-AGR2

check button Fusion gene summary
Fusion gene informationFusion gene name: MTG2-AGR2
Fusion gene ID: 55671
HgeneTgene
Gene symbol

MTG2

AGR2

Gene ID

26164

10551

Gene namemitochondrial ribosome associated GTPase 2anterior gradient 2, protein disulphide isomerase family member
SynonymsGTPBP5|ObgH1|dJ1005F21.2AG-2|AG2|GOB-4|HAG-2|HEL-S-116|HPC8|PDIA17|XAG-2
Cytomap

20q13.33

7p21.1

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial ribosome-associated GTPase 2GTP binding protein 5 (putative)GTP-binding protein 5protein obg homolog 1anterior gradient protein 2 homologanterior gradient homolog 2epididymis secretory protein Li 116protein disulfide isomerase family A, member 17secreted cement gland homologsecreted cement gland protein XAG-2 homolog
Modification date2020031320200313
UniProtAcc

Q9H4K7

O95994

Ensembl transtripts involved in fusion geneENST00000370823, ENST00000436421, 
ENST00000536470, ENST00000461411, 
ENST00000486219, ENST00000401412, 
ENST00000419304, ENST00000419572, 
Fusion gene scores* DoF score3 X 3 X 2=1813 X 9 X 3=351
# samples 313
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(13/351*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MTG2 [Title/Abstract] AND AGR2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMTG2(60776043)-AGR2(16841341), # samples:1
Anticipated loss of major functional domain due to fusion event.MTG2-AGR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAGR2

GO:1903896

positive regulation of IRE1-mediated unfolded protein response

23220234

TgeneAGR2

GO:1903899

positive regulation of PERK-mediated unfolded protein response

23220234


check buttonFusion gene breakpoints across MTG2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AGR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4J5-01AMTG2chr20

60776043

+AGR2chr7

16841341

-


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Fusion Gene ORF analysis for MTG2-AGR2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000370823ENST00000486219MTG2chr20

60776043

+AGR2chr7

16841341

-
5CDS-intronENST00000436421ENST00000486219MTG2chr20

60776043

+AGR2chr7

16841341

-
5CDS-intronENST00000536470ENST00000486219MTG2chr20

60776043

+AGR2chr7

16841341

-
Frame-shiftENST00000370823ENST00000401412MTG2chr20

60776043

+AGR2chr7

16841341

-
Frame-shiftENST00000370823ENST00000419304MTG2chr20

60776043

+AGR2chr7

16841341

-
Frame-shiftENST00000370823ENST00000419572MTG2chr20

60776043

+AGR2chr7

16841341

-
In-frameENST00000436421ENST00000401412MTG2chr20

60776043

+AGR2chr7

16841341

-
In-frameENST00000436421ENST00000419304MTG2chr20

60776043

+AGR2chr7

16841341

-
In-frameENST00000436421ENST00000419572MTG2chr20

60776043

+AGR2chr7

16841341

-
In-frameENST00000536470ENST00000401412MTG2chr20

60776043

+AGR2chr7

16841341

-
In-frameENST00000536470ENST00000419304MTG2chr20

60776043

+AGR2chr7

16841341

-
In-frameENST00000536470ENST00000419572MTG2chr20

60776043

+AGR2chr7

16841341

-
intron-3CDSENST00000461411ENST00000401412MTG2chr20

60776043

+AGR2chr7

16841341

-
intron-3CDSENST00000461411ENST00000419304MTG2chr20

60776043

+AGR2chr7

16841341

-
intron-3CDSENST00000461411ENST00000419572MTG2chr20

60776043

+AGR2chr7

16841341

-
intron-intronENST00000461411ENST00000486219MTG2chr20

60776043

+AGR2chr7

16841341

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000536470MTG2chr2060776043+ENST00000419304AGR2chr716841341-26681122162680172
ENST00000536470MTG2chr2060776043+ENST00000419572AGR2chr716841341-18371122162680172
ENST00000536470MTG2chr2060776043+ENST00000401412AGR2chr716841341-17831122162680172
ENST00000436421MTG2chr2060776043+ENST00000419304AGR2chr716841341-278812421138638166
ENST00000436421MTG2chr2060776043+ENST00000419572AGR2chr716841341-195712421138638166
ENST00000436421MTG2chr2060776043+ENST00000401412AGR2chr716841341-190312421138638166

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000536470ENST00000419304MTG2chr2060776043+AGR2chr716841341-0.601000130.39899984
ENST00000536470ENST00000419572MTG2chr2060776043+AGR2chr716841341-0.298294960.701705
ENST00000536470ENST00000401412MTG2chr2060776043+AGR2chr716841341-0.857970830.14202921
ENST00000436421ENST00000419304MTG2chr2060776043+AGR2chr716841341-0.508758250.4912418
ENST00000436421ENST00000419572MTG2chr2060776043+AGR2chr716841341-0.67471240.32528758
ENST00000436421ENST00000401412MTG2chr2060776043+AGR2chr716841341-0.475427780.52457225

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Fusion Genomic Features for MTG2-AGR2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MTG2-AGR2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:60776043/chr7:16841341)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTG2

Q9H4K7

AGR2

O95994

FUNCTION: Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process. {ECO:0000269|PubMed:17054726, ECO:0000269|PubMed:23396448}.FUNCTION: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113). {ECO:0000250, ECO:0000269|PubMed:18199544, ECO:0000269|PubMed:23274113}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAGR2chr20:60776043chr7:16841341ENST000004193040845_540176.0MotifHomodimer stabilization%3B interchain
TgeneAGR2chr20:60776043chr7:16841341ENST000004193040860_670176.0MotifHomodimer stabilization%3B interchain
TgeneAGR2chr20:60776043chr7:16841341ENST000004193040821_400176.0RegionRequired to promote cell adhesion

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTG2chr20:60776043chr7:16841341ENST00000370823+17225_3900407.0DomainNote=OBG-type G
HgeneMTG2chr20:60776043chr7:16841341ENST00000370823+1770_2240407.0DomainObg
HgeneMTG2chr20:60776043chr7:16841341ENST00000370823+17231_2380407.0Nucleotide bindingGTP
HgeneMTG2chr20:60776043chr7:16841341ENST00000370823+17256_2600407.0Nucleotide bindingGTP
HgeneMTG2chr20:60776043chr7:16841341ENST00000370823+17278_2810407.0Nucleotide bindingGTP
HgeneMTG2chr20:60776043chr7:16841341ENST00000370823+17345_3480407.0Nucleotide bindingGTP
HgeneMTG2chr20:60776043chr7:16841341ENST00000370823+17371_3730407.0Nucleotide bindingGTP
HgeneMTG2chr20:60776043chr7:16841341ENST00000370823+1715_4060407.0RegionNote=Localized in the mitochondria
HgeneMTG2chr20:60776043chr7:16841341ENST00000370823+1730_4060407.0RegionNote=Not localized in the mitochondria


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Fusion Gene Sequence for MTG2-AGR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>55671_55671_1_MTG2-AGR2_MTG2_chr20_60776043_ENST00000436421_AGR2_chr7_16841341_ENST00000401412_length(transcript)=1903nt_BP=1242nt
GTGCTTTCCCGAGCCGGGGCCATGGCACCTGCAAGGTGTTTCTCAGCAAGATTGAGGACCGTGTTTCAGGGCGTGGGGCATTGGGCTTTG
TCCACATGGGCTGGCCTGAAGCCCAGCCGGCTACTGCCACAGCGGGCTTCTCCCAGGCTGCTCTCGGTCGGCCGTGCGGACCTCGCCAAG
CATCAGGAACTCCCGGGGAAGAAGCTGCTCTCTGAGAAAAAGCTGAAAAGGTACTTTGTGGACTATCGGAGAGTGCTTGTCTGTGGAGGA
AACGGAGGCGCTGGGGCAAGCTGCTTCCACAGTGAGCCCCGCAAGGAGTTTGGAGGCCCTGATGGAGGGGACGGAGGCAACGGTGGACAC
GTCATTCTGAGAGCTGGAGCAGCTGCTGTTGCACCTGAAGGTGCTGTATGACGCCTACGCGGAGGCCGAGCTGGGCCAGGGCCGCCAGCC
GCTCAGGTGGTAGCCACGCCAGAGCGGGGTCGCCTCTGGGCCTCTGTCTGAGCAAACCTGGGTGTGAATTCGGTGGTTTTGAATGCATAA
AGTGCCTTGTGGACACGGGGGAGTTGTGGTGCTTCTGGGTCTCTGGGCCCCGCCTGCTGGCCTGAGATGCCCTCATGTTGGGAAGCATTC
CGTGCCCCCTACCCCGCCTGCCCTCCGTATTTCCTGCACCTGTCAGCCTGCACCGACTGATGAGCCAGTTGCTCATTTGTGCTGATTAAC
ACCCCTAATAAGGGGTTGGGGTGCCCATAACGGGGTGGCCCTGCCGCTGACTCAGGTCTCCGCCATGCACGCGTGGACTCTCGGATGAGC
TCAGCAGAACCGCACAGCCAGAGCCCCAGGTCAGAAGTGCAGACCAGGGTTCTCAGCACAGTGCCCGTCGTGCTTCCATGGCTTGCTACG
GAGAGAGACCTCTGGATCCACACTGGGGCTGCGTCTGGCCCGTTGTCCAGCAGCCCTGCGGTACCGCAAGCCCAGGCACCAGTGTCTCGG
GGGGCCTCACTGCTGCGCAAGGGGTGGGGCCGAGGATGCAAGTCCAGGCAGAGCGGCGCAGGCAGCTGTGAGCTTTTCTCCATCAGCCGT
CTGAGAAGAGCAGTGAGGCCAGCTGCTTCCTGTCCTTCAGAACACTTCTCTGTGCTCAGTGGGAGCCAGGAAGCCTCAGGCTTCACGACT
GAATGCACCCAATATCCGACCTGGCTGCGTGTTTCTGGCTGGGCTGCCGTGTGCACAGCAAGTTAACTAGAGACCCATCTCTGACAGTTA
GAGCCGATATCACTGGAAGATATTCAAATCGTCTCTATGCTTACGAACCTGCAGATACAGCTCTGTGTAAGTGTGACCTTCAATTCGGAT
GTTGCCCAAGAGTTGAACACCTCTATTGCTGTAGTGATGGGACTAGAGGCTGCATGGTGAGGTGAGAGAGAGCTAGGCTTAGGGACGCCT
CGGACTCAGTTTGACCCTAACTAGCCTTGCATCTTCAGGCAAATCACACTCTTTCCATCTCAGGTTTGTTTGTTTTTAATCTCAATTGAA
GATGAATTATTTAGATTAGGTATCTTTTTCTCTAGGAGGATTCTATGACCACATTACCTATGAAACAACTGACAAACACCTTTCTCCTGA
TGGCCAGTATGTCCCCAGGATTATGTTTGTTGCTTTAAAGAAAGTGTTTGCTGAAAATAAAGAAATCCAGAAATTGGCAGAGCAGTTTGT
CCTCCTCAATCTGGTTCAACAAACCCTTGATGATTATTCATCACTTGGATGAGTGCCCACACAGTCAAGGTTGGGGTGACCAACTCATCT
GGACTCAGACATATGAAGAAGCTCTATATAAATCCAAGACAAGCTGGAGCCAAAAAGGACACAAAGGACTCTCGACCCAAACTGCCCCAG

>55671_55671_1_MTG2-AGR2_MTG2_chr20_60776043_ENST00000436421_AGR2_chr7_16841341_ENST00000401412_length(amino acids)=166AA_BP=
MSTEKCSEGQEAAGLTALLRRLMEKSSQLPAPLCLDLHPRPHPLRSSEAPRDTGAWACGTAGLLDNGPDAAPVWIQRSLSVASHGSTTGT

--------------------------------------------------------------
>55671_55671_2_MTG2-AGR2_MTG2_chr20_60776043_ENST00000436421_AGR2_chr7_16841341_ENST00000419304_length(transcript)=2788nt_BP=1242nt
GTGCTTTCCCGAGCCGGGGCCATGGCACCTGCAAGGTGTTTCTCAGCAAGATTGAGGACCGTGTTTCAGGGCGTGGGGCATTGGGCTTTG
TCCACATGGGCTGGCCTGAAGCCCAGCCGGCTACTGCCACAGCGGGCTTCTCCCAGGCTGCTCTCGGTCGGCCGTGCGGACCTCGCCAAG
CATCAGGAACTCCCGGGGAAGAAGCTGCTCTCTGAGAAAAAGCTGAAAAGGTACTTTGTGGACTATCGGAGAGTGCTTGTCTGTGGAGGA
AACGGAGGCGCTGGGGCAAGCTGCTTCCACAGTGAGCCCCGCAAGGAGTTTGGAGGCCCTGATGGAGGGGACGGAGGCAACGGTGGACAC
GTCATTCTGAGAGCTGGAGCAGCTGCTGTTGCACCTGAAGGTGCTGTATGACGCCTACGCGGAGGCCGAGCTGGGCCAGGGCCGCCAGCC
GCTCAGGTGGTAGCCACGCCAGAGCGGGGTCGCCTCTGGGCCTCTGTCTGAGCAAACCTGGGTGTGAATTCGGTGGTTTTGAATGCATAA
AGTGCCTTGTGGACACGGGGGAGTTGTGGTGCTTCTGGGTCTCTGGGCCCCGCCTGCTGGCCTGAGATGCCCTCATGTTGGGAAGCATTC
CGTGCCCCCTACCCCGCCTGCCCTCCGTATTTCCTGCACCTGTCAGCCTGCACCGACTGATGAGCCAGTTGCTCATTTGTGCTGATTAAC
ACCCCTAATAAGGGGTTGGGGTGCCCATAACGGGGTGGCCCTGCCGCTGACTCAGGTCTCCGCCATGCACGCGTGGACTCTCGGATGAGC
TCAGCAGAACCGCACAGCCAGAGCCCCAGGTCAGAAGTGCAGACCAGGGTTCTCAGCACAGTGCCCGTCGTGCTTCCATGGCTTGCTACG
GAGAGAGACCTCTGGATCCACACTGGGGCTGCGTCTGGCCCGTTGTCCAGCAGCCCTGCGGTACCGCAAGCCCAGGCACCAGTGTCTCGG
GGGGCCTCACTGCTGCGCAAGGGGTGGGGCCGAGGATGCAAGTCCAGGCAGAGCGGCGCAGGCAGCTGTGAGCTTTTCTCCATCAGCCGT
CTGAGAAGAGCAGTGAGGCCAGCTGCTTCCTGTCCTTCAGAACACTTCTCTGTGCTCAGTGGGAGCCAGGAAGCCTCAGGCTTCACGACT
GAATGCACCCAATATCCGACCTGGCTGCGTGTTTCTGGCTGGGCTGCCGTGTGCACAGCAAGTTAACTAGAGTGCTTGACAACATGAAGA
AAGCTCTCAAGTTGCTGAAGACTGAATTGTAAAGAAAAAAAATCTCCAAGCCCTTCTGTCTGTCAGGCCTTGAGACTTGAAACCAGAAGA
AGTGTGAGAAGACTGGCTAGTGTGGAAGCATAGTGAACACACTGATTAGGTTATGGTTTAATGTTACAACAACTATTTTTTAAGAAAAAC
AAGTTTTAGAAATTTGGTTTCAAGTGTACATGTGTGAAAACAATATTGTATACTACCATAGTGAGCCATGATTTTCTAAAAAAAAAAATA
AATGTTTTGGGGGTGTTCTGTTTTCTCCAACTTGGTCTTTCACAGTGGTTCGTTTACCAAATAGGATTAAACACACACAAAATGCTCAAG
GAAGGGACAAGACAAAACCAAAACTAGTTCAAATGATGAAGACCAAAGACCAAGTTATCATCTCACCACACCACAGGTTCTCACTAGATG
ACTGTAAGTAGACACGAGCTTAATCAACAGAAGTATCAAGCCATGTGCTTTAGCATAAAAGAATATTTAGAAAAACATCCCAAGAAAATC
ACATCACTACCTAGAGTCAACTCTGGCCAGGAACTCTAAGGTACACACTTTCATTTAGTAATTAAATTTTAGTCAGATTTTGCCCAACCT
AATGCTCTCAGGGAAAGCCTCTGGCAAGTAGCTTTCTCCTTCAGAGGTCTAATTTAGTAGAAAGGTCATCCAAAGAACATCTGCACTCCT
GAACACACCCTGAAGAAATCCTGGGAATTGACCTTGTAATCGATTTGTCTGTCAAGGTCCTAAAGTACTGGAGTGAAATAAATTCAGCCA
ACATGTGACTAATTGGAAGAAGAGCAAAGGGTGGTGACGTGTTGATGAGGCAGATGGAGATCAGAGGTTACTAGGGTTTAGGAAACGTGA
AAGGCTGTGGCATCAGGGTAGGGGAGCATTCTGCCTAACAGAAATTAGAATTGTGTGTTAATGTCTTCACTCTATACTTAATCTCACATT
CATTAATATATGGAATTCCTCTACTGCCCAGCCCCTCCTGATTTCTTTGGCCCCTGGACTATGGTGCTGTATATAATGCTTTGCAGTATC
TGTTGCTTGTCTTGATTAACTTTTTTGGATAAAACCTTTTTTGAACAGAACCCATCTCTGACAGTTAGAGCCGATATCACTGGAAGATAT
TCAAATCGTCTCTATGCTTACGAACCTGCAGATACAGCTCTGTTATGAAACAACTGACAAACACCTTTCTCCTGATGGCCAGTATGTCCC
CAGGATTATGTTTGTTGCTTTAAAGAAAGTGTTTGCTGAAAATAAAGAAATCCAGAAATTGGCAGAGCAGTTTGTCCTCCTCAATCTGGT
TCAACAAACCCTTGATGATTATTCATCACTTGGATGAGTGCCCACACAGTCAAGGTTGGGGTGACCAACTCATCTGGACTCAGACATATG

>55671_55671_2_MTG2-AGR2_MTG2_chr20_60776043_ENST00000436421_AGR2_chr7_16841341_ENST00000419304_length(amino acids)=166AA_BP=
MSTEKCSEGQEAAGLTALLRRLMEKSSQLPAPLCLDLHPRPHPLRSSEAPRDTGAWACGTAGLLDNGPDAAPVWIQRSLSVASHGSTTGT

--------------------------------------------------------------
>55671_55671_3_MTG2-AGR2_MTG2_chr20_60776043_ENST00000436421_AGR2_chr7_16841341_ENST00000419572_length(transcript)=1957nt_BP=1242nt
GTGCTTTCCCGAGCCGGGGCCATGGCACCTGCAAGGTGTTTCTCAGCAAGATTGAGGACCGTGTTTCAGGGCGTGGGGCATTGGGCTTTG
TCCACATGGGCTGGCCTGAAGCCCAGCCGGCTACTGCCACAGCGGGCTTCTCCCAGGCTGCTCTCGGTCGGCCGTGCGGACCTCGCCAAG
CATCAGGAACTCCCGGGGAAGAAGCTGCTCTCTGAGAAAAAGCTGAAAAGGTACTTTGTGGACTATCGGAGAGTGCTTGTCTGTGGAGGA
AACGGAGGCGCTGGGGCAAGCTGCTTCCACAGTGAGCCCCGCAAGGAGTTTGGAGGCCCTGATGGAGGGGACGGAGGCAACGGTGGACAC
GTCATTCTGAGAGCTGGAGCAGCTGCTGTTGCACCTGAAGGTGCTGTATGACGCCTACGCGGAGGCCGAGCTGGGCCAGGGCCGCCAGCC
GCTCAGGTGGTAGCCACGCCAGAGCGGGGTCGCCTCTGGGCCTCTGTCTGAGCAAACCTGGGTGTGAATTCGGTGGTTTTGAATGCATAA
AGTGCCTTGTGGACACGGGGGAGTTGTGGTGCTTCTGGGTCTCTGGGCCCCGCCTGCTGGCCTGAGATGCCCTCATGTTGGGAAGCATTC
CGTGCCCCCTACCCCGCCTGCCCTCCGTATTTCCTGCACCTGTCAGCCTGCACCGACTGATGAGCCAGTTGCTCATTTGTGCTGATTAAC
ACCCCTAATAAGGGGTTGGGGTGCCCATAACGGGGTGGCCCTGCCGCTGACTCAGGTCTCCGCCATGCACGCGTGGACTCTCGGATGAGC
TCAGCAGAACCGCACAGCCAGAGCCCCAGGTCAGAAGTGCAGACCAGGGTTCTCAGCACAGTGCCCGTCGTGCTTCCATGGCTTGCTACG
GAGAGAGACCTCTGGATCCACACTGGGGCTGCGTCTGGCCCGTTGTCCAGCAGCCCTGCGGTACCGCAAGCCCAGGCACCAGTGTCTCGG
GGGGCCTCACTGCTGCGCAAGGGGTGGGGCCGAGGATGCAAGTCCAGGCAGAGCGGCGCAGGCAGCTGTGAGCTTTTCTCCATCAGCCGT
CTGAGAAGAGCAGTGAGGCCAGCTGCTTCCTGTCCTTCAGAACACTTCTCTGTGCTCAGTGGGAGCCAGGAAGCCTCAGGCTTCACGACT
GAATGCACCCAATATCCGACCTGGCTGCGTGTTTCTGGCTGGGCTGCCGTGTGCACAGCAAGTTAACTAGAGTGCTTGACAACATGAAGA
AAGCTCTCAAGTTGCTGAAGACTGAATTGTAAAGAAAAAAAATCTCCAAGCCCTTCTGTCTGTCAGGCCTTGAGACTTGAAACCAGAAGA
AGTGTGAGAAGACTGGCTAGTGTGGAAGCATAGTGAACACACTGATTAGGTTATGGTTTAATGTTACAACAACTATTTTTTAAGAAAAAC
AAGTTTTAGAAATTTGGTTTCAAGTGTACATGTGTGAAAACAATATTGTATACTACCATAGTGAGCCATGATTTTCTAAAAAAAAAAATA
AATGTTTTGGGGGTGTTCTGTTTTCTCCACCCATCTCTGACAGTTAGAGCCGATATCACTGGAAGATATTCAAATCGTCTCTATGCTTAC
GAACCTGCAGATACAGCTCTGTTATGAAACAACTGACAAACACCTTTCTCCTGATGGCCAGTATGTCCCCAGGATTATGTTTGTTGCTTT
AAAGAAAGTGTTTGCTGAAAATAAAGAAATCCAGAAATTGGCAGAGCAGTTTGTCCTCCTCAATCTGGTTCAACAAACCCTTGATGATTA
TTCATCACTTGGATGAGTGCCCACACAGTCAAGGTTGGGGTGACCAACTCATCTGGACTCAGACATATGAAGAAGCTCTATATAAATCCA

>55671_55671_3_MTG2-AGR2_MTG2_chr20_60776043_ENST00000436421_AGR2_chr7_16841341_ENST00000419572_length(amino acids)=166AA_BP=
MSTEKCSEGQEAAGLTALLRRLMEKSSQLPAPLCLDLHPRPHPLRSSEAPRDTGAWACGTAGLLDNGPDAAPVWIQRSLSVASHGSTTGT

--------------------------------------------------------------
>55671_55671_4_MTG2-AGR2_MTG2_chr20_60776043_ENST00000536470_AGR2_chr7_16841341_ENST00000401412_length(transcript)=1783nt_BP=1122nt
GTGACGTGCTTTCCCGAGCCGAAAAGGTACTTTGTGGACTATCGGAGAGTGCTTGTCTGTGGAGGAAACGGAGGCGCTGGGGCAAGCTGC
TTCCACAGTGAGCCCCGCAAGGAGTTTGGAGGCCCTGATGGAGGGGACGGAGGCAACGGTGGACACGTCATTCTGAGAGTTGACCAGCAA
GTCAAGTCCCTGTCGTCGGTCCTGTCGCGGTACCAGGGTTTCAGTGGAGAAGATGGAGGGAGTAAAAACTGCTTCGGGCGCAGTGGCGCC
GTCCTCTACATCCGGGTCCCCGTGGGCACGCTGGTGAAGGAGGGAGGCAGAGTTGTGGCCGACCTGTCTTGCGTGGGAGATGAGTACATT
GCCGCGCTGGGCGGGGCAGGAGGGAAAGGCAACCGCTTCTTCCTGGCCAACAACAACCGTGCCCCTGTGACCTGTACCCCTGGACAGCCA
GGACAGCAGCGAGTTCTCCACCTGGAGCTCAAGACGGTGGCCCACGCCGGAATGGTGGGATTCCCCAACGCCGGGAAGTCCTCACTGCTC
CGGGCCATTTCAAACGCCAGACCCGCCGTGGCTTCCTACCCGTTCACCACCCTGAAGCCCCACGTCGGGATCGTCCACTACGAAGGCCAC
CTACAAATAGCAGCTGGAGCAGCTGCTGTTGCACCTGAAGGTGCTGTATGACGCCTACGCGGAGGCCGAGCTGGGCCAGGGCCGCCAGCC
GCTCAGGTGGTAGCCACGCCAGAGCGGGGTCGCCTCTGGGCCTCTGTCTGAGCAAACCTGGGTGTGAATTCGGTGGTTTTGAATGCATAA
AGTGCCTTGTGGACACGGGGGAGTTGTGGTGCTTCTGGGTCTCTGGGCCCCGCCTGCTGGCCTGAGATGCCCTCATGTTGGGAAGCATTC
CGTGCCCCCTACCCCGCCTGCCCTCCGTATTTCCTGCACCTGTCAGCCTGCACCGACTGATGAGCCAGTTGCTCATTTGTGCTGATTAAC
ACCCCTAATAAGGGGTTGGGGTGCCCATAACGGGGTGGCCCTGCCGCTGACTCAGGTCTCCGCCATGCACGCGTGGACTCTCGGATGAGC
TCAGCAGAACCGCACAGCCAGAGCCCCAGGTCAGAAGTGCAGACCCATCTCTGACAGTTAGAGCCGATATCACTGGAAGATATTCAAATC
GTCTCTATGCTTACGAACCTGCAGATACAGCTCTGTGTAAGTGTGACCTTCAATTCGGATGTTGCCCAAGAGTTGAACACCTCTATTGCT
GTAGTGATGGGACTAGAGGCTGCATGGTGAGGTGAGAGAGAGCTAGGCTTAGGGACGCCTCGGACTCAGTTTGACCCTAACTAGCCTTGC
ATCTTCAGGCAAATCACACTCTTTCCATCTCAGGTTTGTTTGTTTTTAATCTCAATTGAAGATGAATTATTTAGATTAGGTATCTTTTTC
TCTAGGAGGATTCTATGACCACATTACCTATGAAACAACTGACAAACACCTTTCTCCTGATGGCCAGTATGTCCCCAGGATTATGTTTGT
TGCTTTAAAGAAAGTGTTTGCTGAAAATAAAGAAATCCAGAAATTGGCAGAGCAGTTTGTCCTCCTCAATCTGGTTCAACAAACCCTTGA
TGATTATTCATCACTTGGATGAGTGCCCACACAGTCAAGGTTGGGGTGACCAACTCATCTGGACTCAGACATATGAAGAAGCTCTATATA

>55671_55671_4_MTG2-AGR2_MTG2_chr20_60776043_ENST00000536470_AGR2_chr7_16841341_ENST00000401412_length(amino acids)=172AA_BP=
MRVDQQVKSLSSVLSRYQGFSGEDGGSKNCFGRSGAVLYIRVPVGTLVKEGGRVVADLSCVGDEYIAALGGAGGKGNRFFLANNNRAPVT

--------------------------------------------------------------
>55671_55671_5_MTG2-AGR2_MTG2_chr20_60776043_ENST00000536470_AGR2_chr7_16841341_ENST00000419304_length(transcript)=2668nt_BP=1122nt
GTGACGTGCTTTCCCGAGCCGAAAAGGTACTTTGTGGACTATCGGAGAGTGCTTGTCTGTGGAGGAAACGGAGGCGCTGGGGCAAGCTGC
TTCCACAGTGAGCCCCGCAAGGAGTTTGGAGGCCCTGATGGAGGGGACGGAGGCAACGGTGGACACGTCATTCTGAGAGTTGACCAGCAA
GTCAAGTCCCTGTCGTCGGTCCTGTCGCGGTACCAGGGTTTCAGTGGAGAAGATGGAGGGAGTAAAAACTGCTTCGGGCGCAGTGGCGCC
GTCCTCTACATCCGGGTCCCCGTGGGCACGCTGGTGAAGGAGGGAGGCAGAGTTGTGGCCGACCTGTCTTGCGTGGGAGATGAGTACATT
GCCGCGCTGGGCGGGGCAGGAGGGAAAGGCAACCGCTTCTTCCTGGCCAACAACAACCGTGCCCCTGTGACCTGTACCCCTGGACAGCCA
GGACAGCAGCGAGTTCTCCACCTGGAGCTCAAGACGGTGGCCCACGCCGGAATGGTGGGATTCCCCAACGCCGGGAAGTCCTCACTGCTC
CGGGCCATTTCAAACGCCAGACCCGCCGTGGCTTCCTACCCGTTCACCACCCTGAAGCCCCACGTCGGGATCGTCCACTACGAAGGCCAC
CTACAAATAGCAGCTGGAGCAGCTGCTGTTGCACCTGAAGGTGCTGTATGACGCCTACGCGGAGGCCGAGCTGGGCCAGGGCCGCCAGCC
GCTCAGGTGGTAGCCACGCCAGAGCGGGGTCGCCTCTGGGCCTCTGTCTGAGCAAACCTGGGTGTGAATTCGGTGGTTTTGAATGCATAA
AGTGCCTTGTGGACACGGGGGAGTTGTGGTGCTTCTGGGTCTCTGGGCCCCGCCTGCTGGCCTGAGATGCCCTCATGTTGGGAAGCATTC
CGTGCCCCCTACCCCGCCTGCCCTCCGTATTTCCTGCACCTGTCAGCCTGCACCGACTGATGAGCCAGTTGCTCATTTGTGCTGATTAAC
ACCCCTAATAAGGGGTTGGGGTGCCCATAACGGGGTGGCCCTGCCGCTGACTCAGGTCTCCGCCATGCACGCGTGGACTCTCGGATGAGC
TCAGCAGAACCGCACAGCCAGAGCCCCAGGTCAGAAGTGCAGTGCTTGACAACATGAAGAAAGCTCTCAAGTTGCTGAAGACTGAATTGT
AAAGAAAAAAAATCTCCAAGCCCTTCTGTCTGTCAGGCCTTGAGACTTGAAACCAGAAGAAGTGTGAGAAGACTGGCTAGTGTGGAAGCA
TAGTGAACACACTGATTAGGTTATGGTTTAATGTTACAACAACTATTTTTTAAGAAAAACAAGTTTTAGAAATTTGGTTTCAAGTGTACA
TGTGTGAAAACAATATTGTATACTACCATAGTGAGCCATGATTTTCTAAAAAAAAAAATAAATGTTTTGGGGGTGTTCTGTTTTCTCCAA
CTTGGTCTTTCACAGTGGTTCGTTTACCAAATAGGATTAAACACACACAAAATGCTCAAGGAAGGGACAAGACAAAACCAAAACTAGTTC
AAATGATGAAGACCAAAGACCAAGTTATCATCTCACCACACCACAGGTTCTCACTAGATGACTGTAAGTAGACACGAGCTTAATCAACAG
AAGTATCAAGCCATGTGCTTTAGCATAAAAGAATATTTAGAAAAACATCCCAAGAAAATCACATCACTACCTAGAGTCAACTCTGGCCAG
GAACTCTAAGGTACACACTTTCATTTAGTAATTAAATTTTAGTCAGATTTTGCCCAACCTAATGCTCTCAGGGAAAGCCTCTGGCAAGTA
GCTTTCTCCTTCAGAGGTCTAATTTAGTAGAAAGGTCATCCAAAGAACATCTGCACTCCTGAACACACCCTGAAGAAATCCTGGGAATTG
ACCTTGTAATCGATTTGTCTGTCAAGGTCCTAAAGTACTGGAGTGAAATAAATTCAGCCAACATGTGACTAATTGGAAGAAGAGCAAAGG
GTGGTGACGTGTTGATGAGGCAGATGGAGATCAGAGGTTACTAGGGTTTAGGAAACGTGAAAGGCTGTGGCATCAGGGTAGGGGAGCATT
CTGCCTAACAGAAATTAGAATTGTGTGTTAATGTCTTCACTCTATACTTAATCTCACATTCATTAATATATGGAATTCCTCTACTGCCCA
GCCCCTCCTGATTTCTTTGGCCCCTGGACTATGGTGCTGTATATAATGCTTTGCAGTATCTGTTGCTTGTCTTGATTAACTTTTTTGGAT
AAAACCTTTTTTGAACAGAACCCATCTCTGACAGTTAGAGCCGATATCACTGGAAGATATTCAAATCGTCTCTATGCTTACGAACCTGCA
GATACAGCTCTGTTATGAAACAACTGACAAACACCTTTCTCCTGATGGCCAGTATGTCCCCAGGATTATGTTTGTTGCTTTAAAGAAAGT
GTTTGCTGAAAATAAAGAAATCCAGAAATTGGCAGAGCAGTTTGTCCTCCTCAATCTGGTTCAACAAACCCTTGATGATTATTCATCACT
TGGATGAGTGCCCACACAGTCAAGGTTGGGGTGACCAACTCATCTGGACTCAGACATATGAAGAAGCTCTATATAAATCCAAGACAAGCT

>55671_55671_5_MTG2-AGR2_MTG2_chr20_60776043_ENST00000536470_AGR2_chr7_16841341_ENST00000419304_length(amino acids)=172AA_BP=
MRVDQQVKSLSSVLSRYQGFSGEDGGSKNCFGRSGAVLYIRVPVGTLVKEGGRVVADLSCVGDEYIAALGGAGGKGNRFFLANNNRAPVT

--------------------------------------------------------------
>55671_55671_6_MTG2-AGR2_MTG2_chr20_60776043_ENST00000536470_AGR2_chr7_16841341_ENST00000419572_length(transcript)=1837nt_BP=1122nt
GTGACGTGCTTTCCCGAGCCGAAAAGGTACTTTGTGGACTATCGGAGAGTGCTTGTCTGTGGAGGAAACGGAGGCGCTGGGGCAAGCTGC
TTCCACAGTGAGCCCCGCAAGGAGTTTGGAGGCCCTGATGGAGGGGACGGAGGCAACGGTGGACACGTCATTCTGAGAGTTGACCAGCAA
GTCAAGTCCCTGTCGTCGGTCCTGTCGCGGTACCAGGGTTTCAGTGGAGAAGATGGAGGGAGTAAAAACTGCTTCGGGCGCAGTGGCGCC
GTCCTCTACATCCGGGTCCCCGTGGGCACGCTGGTGAAGGAGGGAGGCAGAGTTGTGGCCGACCTGTCTTGCGTGGGAGATGAGTACATT
GCCGCGCTGGGCGGGGCAGGAGGGAAAGGCAACCGCTTCTTCCTGGCCAACAACAACCGTGCCCCTGTGACCTGTACCCCTGGACAGCCA
GGACAGCAGCGAGTTCTCCACCTGGAGCTCAAGACGGTGGCCCACGCCGGAATGGTGGGATTCCCCAACGCCGGGAAGTCCTCACTGCTC
CGGGCCATTTCAAACGCCAGACCCGCCGTGGCTTCCTACCCGTTCACCACCCTGAAGCCCCACGTCGGGATCGTCCACTACGAAGGCCAC
CTACAAATAGCAGCTGGAGCAGCTGCTGTTGCACCTGAAGGTGCTGTATGACGCCTACGCGGAGGCCGAGCTGGGCCAGGGCCGCCAGCC
GCTCAGGTGGTAGCCACGCCAGAGCGGGGTCGCCTCTGGGCCTCTGTCTGAGCAAACCTGGGTGTGAATTCGGTGGTTTTGAATGCATAA
AGTGCCTTGTGGACACGGGGGAGTTGTGGTGCTTCTGGGTCTCTGGGCCCCGCCTGCTGGCCTGAGATGCCCTCATGTTGGGAAGCATTC
CGTGCCCCCTACCCCGCCTGCCCTCCGTATTTCCTGCACCTGTCAGCCTGCACCGACTGATGAGCCAGTTGCTCATTTGTGCTGATTAAC
ACCCCTAATAAGGGGTTGGGGTGCCCATAACGGGGTGGCCCTGCCGCTGACTCAGGTCTCCGCCATGCACGCGTGGACTCTCGGATGAGC
TCAGCAGAACCGCACAGCCAGAGCCCCAGGTCAGAAGTGCAGTGCTTGACAACATGAAGAAAGCTCTCAAGTTGCTGAAGACTGAATTGT
AAAGAAAAAAAATCTCCAAGCCCTTCTGTCTGTCAGGCCTTGAGACTTGAAACCAGAAGAAGTGTGAGAAGACTGGCTAGTGTGGAAGCA
TAGTGAACACACTGATTAGGTTATGGTTTAATGTTACAACAACTATTTTTTAAGAAAAACAAGTTTTAGAAATTTGGTTTCAAGTGTACA
TGTGTGAAAACAATATTGTATACTACCATAGTGAGCCATGATTTTCTAAAAAAAAAAATAAATGTTTTGGGGGTGTTCTGTTTTCTCCAC
CCATCTCTGACAGTTAGAGCCGATATCACTGGAAGATATTCAAATCGTCTCTATGCTTACGAACCTGCAGATACAGCTCTGTTATGAAAC
AACTGACAAACACCTTTCTCCTGATGGCCAGTATGTCCCCAGGATTATGTTTGTTGCTTTAAAGAAAGTGTTTGCTGAAAATAAAGAAAT
CCAGAAATTGGCAGAGCAGTTTGTCCTCCTCAATCTGGTTCAACAAACCCTTGATGATTATTCATCACTTGGATGAGTGCCCACACAGTC
AAGGTTGGGGTGACCAACTCATCTGGACTCAGACATATGAAGAAGCTCTATATAAATCCAAGACAAGCTGGAGCCAAAAAGGACACAAAG

>55671_55671_6_MTG2-AGR2_MTG2_chr20_60776043_ENST00000536470_AGR2_chr7_16841341_ENST00000419572_length(amino acids)=172AA_BP=
MRVDQQVKSLSSVLSRYQGFSGEDGGSKNCFGRSGAVLYIRVPVGTLVKEGGRVVADLSCVGDEYIAALGGAGGKGNRFFLANNNRAPVT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MTG2-AGR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MTG2-AGR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MTG2-AGR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource