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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MTHFD1L-AKAP12 (FusionGDB2 ID:55675)

Fusion Gene Summary for MTHFD1L-AKAP12

check button Fusion gene summary
Fusion gene informationFusion gene name: MTHFD1L-AKAP12
Fusion gene ID: 55675
HgeneTgene
Gene symbol

MTHFD1L

AKAP12

Gene ID

25902

9590

Gene namemethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 likeA-kinase anchoring protein 12
SynonymsFTHFSDC1|MTC1THFS|dJ292B18.2AKAP250|SSeCKS
Cytomap

6q25.1

6q25.1

Type of geneprotein-codingprotein-coding
Descriptionmonofunctional C1-tetrahydrofolate synthase, mitochondrial10-formyl-THF synthetaseformyltetrahydrofolate synthetase domain containing 1A-kinase anchor protein 12A kinase (PRKA) anchor protein 12A-kinase anchor protein, 250kDaAKAP 250Src-Suppressed C Kinase Substratekinase scaffold protein gravinmyasthenia gravis autoantigen gravin
Modification date2020031320200327
UniProtAcc

Q6UB35

Q02952

Ensembl transtripts involved in fusion geneENST00000367321, ENST00000367307, 
ENST00000478643, 		ENST00000354675, 
ENST00000359755, ENST00000490177, 
ENST00000253332, ENST00000402676, 
Fusion gene scores* DoF score11 X 14 X 5=7709 X 9 X 6=486
# samples 1311
** MAII scorelog2(13/770*10)=-2.56634682255381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/486*10)=-2.14345279008112
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MTHFD1L [Title/Abstract] AND AKAP12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMTHFD1L(151336829)-AKAP12(151626882), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMTHFD1L

GO:0006760

folic acid-containing compound metabolic process

12937168

HgeneMTHFD1L

GO:0009257

10-formyltetrahydrofolate biosynthetic process

12937168

HgeneMTHFD1L

GO:0015942

formate metabolic process

16171773


check buttonFusion gene breakpoints across MTHFD1L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AKAP12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-NA-A4R1MTHFD1Lchr6

151336829

+AKAP12chr6

151626882

+


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Fusion Gene ORF analysis for MTHFD1L-AKAP12

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000367321ENST00000354675MTHFD1Lchr6

151336829

+AKAP12chr6

151626882

+
5CDS-intronENST00000367321ENST00000359755MTHFD1Lchr6

151336829

+AKAP12chr6

151626882

+
5CDS-intronENST00000367321ENST00000490177MTHFD1Lchr6

151336829

+AKAP12chr6

151626882

+
In-frameENST00000367321ENST00000253332MTHFD1Lchr6

151336829

+AKAP12chr6

151626882

+
In-frameENST00000367321ENST00000402676MTHFD1Lchr6

151336829

+AKAP12chr6

151626882

+
intron-3CDSENST00000367307ENST00000253332MTHFD1Lchr6

151336829

+AKAP12chr6

151626882

+
intron-3CDSENST00000367307ENST00000402676MTHFD1Lchr6

151336829

+AKAP12chr6

151626882

+
intron-3CDSENST00000478643ENST00000253332MTHFD1Lchr6

151336829

+AKAP12chr6

151626882

+
intron-3CDSENST00000478643ENST00000402676MTHFD1Lchr6

151336829

+AKAP12chr6

151626882

+
intron-intronENST00000367307ENST00000354675MTHFD1Lchr6

151336829

+AKAP12chr6

151626882

+
intron-intronENST00000367307ENST00000359755MTHFD1Lchr6

151336829

+AKAP12chr6

151626882

+
intron-intronENST00000367307ENST00000490177MTHFD1Lchr6

151336829

+AKAP12chr6

151626882

+
intron-intronENST00000478643ENST00000354675MTHFD1Lchr6

151336829

+AKAP12chr6

151626882

+
intron-intronENST00000478643ENST00000359755MTHFD1Lchr6

151336829

+AKAP12chr6

151626882

+
intron-intronENST00000478643ENST00000490177MTHFD1Lchr6

151336829

+AKAP12chr6

151626882

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367321MTHFD1Lchr6151336829+ENST00000402676AKAP12chr6151626882+1089028602580462673
ENST00000367321MTHFD1Lchr6151336829+ENST00000253332AKAP12chr6151626882+910628602580462673

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367321ENST00000402676MTHFD1Lchr6151336829+AKAP12chr6151626882+0.0009694380.9990306
ENST00000367321ENST00000253332MTHFD1Lchr6151336829+AKAP12chr6151626882+0.0019606670.9980393

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Fusion Genomic Features for MTHFD1L-AKAP12


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MTHFD1L-AKAP12


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:151336829/chr6:151626882)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTHFD1L

Q6UB35

AKAP12

Q02952

FUNCTION: May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. {ECO:0000250, ECO:0000269|PubMed:16171773}.FUNCTION: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTHFD1Lchr6:151336829chr6:151626882ENST00000367321+242834_42862932.6666666666666Compositional biasNote=Poly-Gly
HgeneMTHFD1Lchr6:151336829chr6:151626882ENST00000367321+2428423_430862932.6666666666666Nucleotide bindingATP
HgeneMTHFD1Lchr6:151336829chr6:151626882ENST00000367321+242831_348862932.6666666666666RegionNote=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase
TgeneAKAP12chr6:151336829chr6:151626882ENST000002533320498_101542015.0Compositional biasNote=Poly-Glu
TgeneAKAP12chr6:151336829chr6:151626882ENST000003546750398_10101968.0Compositional biasNote=Poly-Glu
TgeneAKAP12chr6:151336829chr6:151626882ENST000003597550398_10101993.3333333333333Compositional biasNote=Poly-Glu
TgeneAKAP12chr6:151336829chr6:151626882ENST000004026761598_101542706.3333333333335Compositional biasNote=Poly-Glu
TgeneAKAP12chr6:151336829chr6:151626882ENST0000025333204607_627542015.0MotifAKAP CaM-binding 1
TgeneAKAP12chr6:151336829chr6:151626882ENST0000025333204756_776542015.0MotifAKAP CaM-binding 2
TgeneAKAP12chr6:151336829chr6:151626882ENST0000025333204801_821542015.0MotifAKAP CaM-binding 3
TgeneAKAP12chr6:151336829chr6:151626882ENST0000035467503607_62701968.0MotifAKAP CaM-binding 1
TgeneAKAP12chr6:151336829chr6:151626882ENST0000035467503756_77601968.0MotifAKAP CaM-binding 2
TgeneAKAP12chr6:151336829chr6:151626882ENST0000035467503801_82101968.0MotifAKAP CaM-binding 3
TgeneAKAP12chr6:151336829chr6:151626882ENST0000035975503607_62701993.3333333333333MotifAKAP CaM-binding 1
TgeneAKAP12chr6:151336829chr6:151626882ENST0000035975503756_77601993.3333333333333MotifAKAP CaM-binding 2
TgeneAKAP12chr6:151336829chr6:151626882ENST0000035975503801_82101993.3333333333333MotifAKAP CaM-binding 3
TgeneAKAP12chr6:151336829chr6:151626882ENST0000040267615607_627542706.3333333333335MotifAKAP CaM-binding 1
TgeneAKAP12chr6:151336829chr6:151626882ENST0000040267615756_776542706.3333333333335MotifAKAP CaM-binding 2
TgeneAKAP12chr6:151336829chr6:151626882ENST0000040267615801_821542706.3333333333335MotifAKAP CaM-binding 3
TgeneAKAP12chr6:151336829chr6:151626882ENST00000253332041541_1554542015.0RegionRII-binding
TgeneAKAP12chr6:151336829chr6:151626882ENST0000025333204266_557542015.0RegionInvolved in PKC-binding
TgeneAKAP12chr6:151336829chr6:151626882ENST00000354675031541_155401968.0RegionRII-binding
TgeneAKAP12chr6:151336829chr6:151626882ENST0000035467503266_55701968.0RegionInvolved in PKC-binding
TgeneAKAP12chr6:151336829chr6:151626882ENST00000359755031541_155401993.3333333333333RegionRII-binding
TgeneAKAP12chr6:151336829chr6:151626882ENST0000035975503266_55701993.3333333333333RegionInvolved in PKC-binding
TgeneAKAP12chr6:151336829chr6:151626882ENST00000402676151541_1554542706.3333333333335RegionRII-binding
TgeneAKAP12chr6:151336829chr6:151626882ENST0000040267615266_557542706.3333333333335RegionInvolved in PKC-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTHFD1Lchr6:151336829chr6:151626882ENST00000367307+1834_420276.0Compositional biasNote=Poly-Gly
HgeneMTHFD1Lchr6:151336829chr6:151626882ENST00000367307+18423_4300276.0Nucleotide bindingATP
HgeneMTHFD1Lchr6:151336829chr6:151626882ENST00000367307+1831_3480276.0RegionNote=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase
HgeneMTHFD1Lchr6:151336829chr6:151626882ENST00000367307+18349_9780276.0RegionNote=Formyltetrahydrofolate synthetase
HgeneMTHFD1Lchr6:151336829chr6:151626882ENST00000367321+2428349_978862932.6666666666666RegionNote=Formyltetrahydrofolate synthetase


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Fusion Gene Sequence for MTHFD1L-AKAP12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>55675_55675_1_MTHFD1L-AKAP12_MTHFD1L_chr6_151336829_ENST00000367321_AKAP12_chr6_151626882_ENST00000253332_length(transcript)=9106nt_BP=2860nt
TGAGTCCCACTCCGCACCCCACCCTCTGTCTGGTACAGCTTACCAAACCAAAGTGCCCAAAGCCGTGACATCCCGGCCGGCGGCTCGCAG
GCCCCCGCCCTCCGCACGTCACGGCCGCCGGGTGCAGTGCCCCCTAGGGGCCCCTGGGACGAGGAGGAAGCGCCAGGTCCTTCCCGCCGC
CGCCGCCGCCGCCGCCGCCTGCTCCCCTGGCACGCGCCCCGCCGCCCTCGGCAGCCGCAGCTCCGTGTCCCCTGAGAACCAGCCGTCCCG
CGCCATGGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTG
TCGCGCTAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAG
CAGCTGCAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATT
GCAAGAAAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGC
TGAGGAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGATTATAGATGAAATCTTAAAGATCAATGA
AGATACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAACTTGTTTAGCAACAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGT
GGATGGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGGGATGCCCATGAATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGA
ACTTCTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATTTTGGTAGTGGGGGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCT
GTTCCAGAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAAACACGCCAGCTTCAAAGCAAGCTTCACGAGGCTGACATTGTGGTCCT
AGGCTCACCTAAGCCAGAAGAGATTCCCCTTACTTGGATACAACCAGGAACTACTGTTCTCAACTGCTCCCATGACTTCCTGTCAGGGAA
GGTTGGGTGTGGCTCTCCAAGAATACATTTTGGTGGACTCATTGAGGAAGATGATGTGATTCTCCTTGCTGCAGCTCTGCGAATTCAGAA
CATGGTCAGTAGTGGAAGGAGATGGCTTCGTGAACAGCAGCACAGGCGGTGGAGACTTCACTGCTTGAAACTTCAGCCTCTCTCCCCTGT
GCCAAGTGACATTGAGATTTCAAGAGGACAAACTCCAAAAGCTGTGGATGTCCTTGCCAAGGAGATTGGATTGCTTGCAGATGAAATTGA
AATCTATGGCAAAAGCAAAGCCAAAGTACGTTTGTCCGTGCTAGAAAGGTTAAAGGATCAAGCAGATGGAAAATACGTCTTAGTTGCTGG
GATCACACCCACCCCTCTTGGAGAAGGGAAGAGCACAGTCACCATCGGGCTTGTGCAGGCTCTGACCGCACACCTGAATGTCAACTCCTT
TGCCTGCTTGAGGCAGCCTTCCCAAGGACCGACGTTTGGAGTGAAAGGAGGAGCCGCGGGTGGTGGATATGCCCAGGTCATCCCCATGGA
GGAGTTCAACCTTCACTTGACTGGAGACATCCACGCCATCACCGCTGCCAATAACTTGCTGGCTGCCGCCATCGACACGAGGATTCTTCA
TGAAAACACGCAAACAGATAAGGCTCTGTATAATCGGCTGGTTCCTTTAGTGAATGGTGTCAGAGAATTTTCAGAAATTCAGCTTGCTCG
GCTAAAAAAACTGGGAATAAATAAGACTGATCCGAGCACACTGACAGAAGAGGAAGTGAGTAAATTTGCCCGTCTCGACATCGACCCATC
TACCATCACGTGGCAGAGAGTATTGGATACAAATGACCGATTTCTACGAAAAATAACCATCGGGCAGGGAAACACAGAGAAGGGCCATTA
CCGGCAGGCGCAGTTTGACATCGCAGTGGCCAGCGAGATCATGGCGGTGCTGGCCCTGACGGACAGCCTCGCAGACATGAAGGCACGGCT
GGGAAGGATGGTGGTGGCCAGTGACAAAAGCGGGCAGCCTGTGACAGCAGATGATTTGGGGGTGACAGGTGCTTTGACAGTTTTGATGAA
AGATGCAATAAAACCAAACCTGATGCAGACCCTGGAAGGGACACCTGTGTTCGTGCATGCGGGCCCTTTTGCTAACATTGCTCACGGCAA
CTCTTCAGTGTTGGCTGATAAAATTGCCCTGAAACTGGTTGGTGAAGAAGGATTTGTAGTGACCGAAGCTGGCTTTGGTGCTGACATCGG
AATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGAT
GCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTG
TAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGA
GATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGT
GGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGCTCCTACAGAAGAATGGTCA
GCTGTCCACCATCAATGGCGTAGCTGAGCAAGATGAGCTCAGCCTCCAGGAGGGTGACCTAAATGGCCAGAAAGGAGCCCTGAACGGTCA
AGGAGCCCTAAACAGCCAGGAGGAAGAAGAAGTCATTGTCACAGAGGTTGGACAGAGAGACTCTGAAGATGTGAGCAAAAGAGACTCCGA
TAAAGAGATGGCTACTAAGTCAGCGGTTGTTCACGACATCACAGATGATGGGCAGGAGGAGACACCCGAAATAATCGAACAGATTCCTTC
TTCAGAAAGCAATTTAGAAGAGCTAACACAACCCACTGAGTCCCAGGCTAATGATATTGGATTTAAGAAGGTGTTTAAGTTTGTTGGCTT
TAAATTCACTGTGAAAAAGGATAAGACAGAGAAGCCTGACACTGTCCAGCTACTCACTGTGAAGAAAGATGAAGGGGAGGGAGCAGCAGG
GGCTGGCGACCACAAGGACCCCAGCCTTGGGGCTGGAGAAGCAGCATCCAAAGAAAGCGAACCCAAACAATCTACAGAGAAACCCGAAGA
GACCCTGAAGCGTGAGCAAAGCCACGCAGAAATTTCTCCCCCAGCCGAATCTGGCCAAGCAGTGGAGGAATGCAAAGAGGAAGGAGAAGA
GAAACAAGAAAAAGAACCTAGCAAGTCTGCAGAATCTCCGACTAGTCCCGTGACCAGTGAAACAGGATCAACCTTCAAAAAATTCTTCAC
TCAAGGTTGGGCCGGCTGGCGCAAAAAGACCAGTTTCAGGAAGCCGAAGGAGGATGAAGTGGAAGCTTCAGAGAAGAAAAAGGAACAAGA
GCCAGAAAAAGTAGACACAGAAGAAGACGGAAAGGCAGAGGTTGCCTCCGAGAAACTGACCGCCTCCGAGCAAGCCCACCCACAGGAGCC
GGCAGAAAGTGCCCACGAGCCCCGGTTATCAGCTGAATATGAGAAAGTTGAGCTGCCCTCAGAGGAGCAAGTCAGTGGCTCGCAGGGACC
TTCTGAAGAGAAACCTGCTCCGTTGGCGACAGAAGTGTTTGATGAGAAAATAGAAGTCCACCAAGAAGAGGTTGTGGCCGAAGTCCACGT
CAGCACCGTGGAGGAGAGAACCGAAGAGCAGAAAACGGAGGTGGAAGAAACAGCAGGGTCTGTGCCAGCTGAAGAATTGGTTGAAATGGA
TGCAGAACCTCAGGAAGCTGAACCTGCCAAGGAGCTGGTGAAGCTCAAAGAAACGTGTGTTTCCGGAGAGGACCCTACACAGGGAGCTGA
CCTCAGTCCTGATGAGAAGGTGCTGTCCAAACCCCCCGAAGGCGTTGTGAGTGAGGTGGAAATGCTGTCATCACAGGAGAGAATGAAGGT
GCAGGGAAGTCCACTAAAGAAGCTTTTTACCAGCACTGGCTTAAAAAAGCTTTCTGGAAAGAAACAGAAAGGGAAAAGAGGAGGAGGAGA
CGAGGAATCAGGGGAGCACACTCAGGTTCCAGCCGATTCTCCGGACAGCCAGGAGGAGCAAAAGGGCGAGAGCTCTGCCTCATCCCCTGA
GGAGCCCGAGGAGATCACGTGTCTGGAAAAGGGCTTAGCCGAGGTGCAGCAGGATGGGGAAGCTGAAGAAGGAGCTACTTCCGATGGAGA
GAAAAAAAGAGAAGGTGTCACTCCCTGGGCATCATTCAAAAAGATGGTGACGCCCAAGAAGCGTGTTAGACGGCCTTCGGAAAGTGATAA
AGAAGATGAGCTGGACAAGGTCAAGAGCGCTACCTTGTCTTCCACCGAGAGCACAGCCTCTGAAATGCAAGAAGAAATGAAAGGGAGCGT
GGAAGAGCCAAAGCCGGAAGAACCAAAGCGCAAGGTGGATACCTCAGTATCTTGGGAAGCTTTAATTTGTGTGGGATCATCCAAGAAAAG
AGCAAGGAGAGGGTCCTCTTCTGATGAGGAAGGGGGACCAAAAGCAATGGGAGGAGACCACCAGAAAGCTGATGAGGCCGGAAAAGACAA
AGAGACGGGGACAGACGGGATCCTTGCTGGTTCCCAAGAACATGATCCAGGGCAGGGAAGTTCCTCCCCGGAGCAAGCTGGAAGCCCTAC
CGAAGGGGAGGGCGTTTCCACCTGGGAGTCATTTAAAAGGTTAGTCACGCCAAGAAAAAAATCAAAGTCCAAGCTGGAAGAGAAAAGCGA
AGACTCCATAGCTGGGTCTGGTGTAGAACATTCCACTCCAGACACTGAACCCGGTAAAGAAGAATCCTGGGTCTCAATCAAGAAGTTTAT
TCCTGGACGAAGGAAGAAAAGGCCAGATGGGAAACAAGAACAAGCCCCTGTTGAAGACGCAGGGCCAACAGGGGCCAACGAAGATGACTC
TGATGTCCCGGCCGTGGTCCCTCTGTCTGAGTATGATGCTGTAGAAAGGGAGAAAATGGAGGCACAGCAAGCCCAAAAAAGCGCAGAGCA
GCCCGAGCAGAAGGCAGCCACTGAGGTGTCCAAGGAGCTCAGCGAGAGTCAGGTTCATATGATGGCAGCAGCTGTCGCTGACGGGACGAG
GGCAGCTACCATTATTGAAGAAAGGTCTCCTTCTTGGATATCTGCTTCAGTGACAGAACCTCTTGAACAAGTAGAAGCTGAAGCCGCACT
GTTAACTGAGGAGGTATTGGAAAGAGAAGTAATTGCAGAAGAAGAACCCCCCACGGTTACTGAACCTCTGCCAGAGAACAGAGAGGCCCG
GGGCGACACGGTCGTTAGTGAGGCGGAATTGACCCCCGAAGCTGTGACAGCTGCAGAAACTGCAGGGCCATTGGGTGCCGAAGAAGGAAC
CGAAGCATCTGCTGCTGAAGAGACCACAGAAATGGTGTCAGCAGTCTCCCAGTTAACCGACTCCCCAGACACCACAGAGGAGGCCACTCC
GGTGCAGGAGGTGGAAGGTGGCGTACCTGACATAGAAGAGCAAGAGAGGCGGACTCAAGAGGTCCTCCAGGCAGTGGCAGAAAAAGTGAA
AGAGGAATCCCAGCTGCCTGGCACCGGTGGGCCAGAAGATGTGCTTCAGCCTGTGCAGAGAGCAGAGGCAGAAAGACCAGAAGAGCAGGC
TGAAGCGTCGGGTCTGAAGAAAGAGACGGATGTAGTGTTGAAAGTAGATGCTCAGGAGGCAAAAACTGAGCCTTTTACACAAGGGAAGGT
GGTGGGGCAGACCACCCCAGAAAGCTTTGAAAAAGCTCCTCAAGTCACAGAGAGCATAGAGTCCAGTGAGCTTGTAACCACTTGTCAAGC
CGAAACCTTAGCTGGGGTAAAATCACAGGAGATGGTGATGGAACAGGCTATCCCCCCTGACTCGGTGGAAACCCCTACAGACAGTGAGAC
TGATGGAAGCACCCCCGTAGCCGACTTTGACGCACCAGGCACAACCCAGAAAGACGAGATTGTGGAAATCCATGAGGAGAATGAGGTCGC
ATCTGGTACCCAGTCAGGGGGCACAGAAGCAGAGGCAGTTCCTGCACAGAAAGAGAGGCCTCCAGCACCTTCCAGTTTTGTGTTCCAGGA
AGAAACTAAAGAACAATCAAAGATGGAAGACACTCTAGAGCATACAGATAAAGAGGTGTCAGTGGAAACTGTATCCATTCTGTCAAAGAC
TGAGGGGACTCAAGAGGCTGACCAGTATGCTGATGAGAAAACCAAAGACGTACCATTTTTCGAAGGACTTGAGGGGTCTATAGACACAGG
CATAACAGTCAGTCGGGAAAAGGTCACTGAAGTTGCCCTTAAAGGTGAAGGGACAGAAGAAGCTGAATGTAAAAAGGATGATGCTCTTGA
ACTGCAGAGTCACGCTAAGTCTCCTCCATCCCCCGTGGAGAGAGAGATGGTAGTTCAAGTCGAAAGGGAGAAAACAGAAGCAGAGCCAAC
CCATGTGAATGAAGAGAAGCTTGAGCACGAAACAGCTGTTACCGTATCTGAAGAGGTCAGTAAGCAGCTCCTCCAGACAGTGAATGTGCC
CATCATAGATGGGGCAAAGGAAGTCAGCAGTTTGGAAGGAAGCCCTCCTCCCTGCCTAGGTCAAGAGGAGGCAGTATGCACCAAAATTCA
AGTTCAGAGCTCTGAGGCATCATTCACTCTAACAGCGGCTGCAGAGGAGGAAAAGGTCTTAGGAGAAACTGCCAACATTTTAGAAACAGG
TGAAACGTTGGAGCCTGCAGGTGCACATTTAGTTCTGGAAGAGAAATCCTCTGAAAAAAATGAAGACTTTGCCGCTCATCCAGGGGAAGA
TGCTGTGCCCACAGGGCCCGACTGTCAGGCAAAATCGACACCAGTGATAGTATCTGCTACTACCAAGAAAGGCTTAAGTTCCGACCTGGA
AGGAGAGAAAACCACATCACTGAAGTGGAAGTCAGATGAAGTCGATGAGCAGGTTGCTTGCCAGGAGGTCAAAGTGAGTGTAGCAATTGA
GGATTTAGAGCCTGAAAATGGGATTTTGGAACTTGAGACCAAAAGCAGTAAACTTGTCCAAAACATCATCCAGACAGCCGTTGACCAGTT
TGTACGTACAGAAGAAACAGCCACCGAAATGTTGACGTCTGAGTTACAGACACAAGCTCACGTGATAAAAGCTGACAGCCAGGACGCTGG
ACAGGAAACGGAGAAAGAAGGAGAGGAACCTCAGGCCTCTGCACAGGATGAAACACCAATTACTTCAGCCAAAGAGGAGTCAGAGTCAAC
CGCAGTGGGACAAGCACATTCTGATATTTCCAAAGACATGAGTGAAGCCTCAGAAAAGACCATGACTGTTGAGGTAGAAGGTTCCACTGT
AAATGATCAGCAGCTGGAAGAGGTCGTCCTCCCATCTGAGGAAGAGGGAGGTGGAGCTGGAACAAAGTCTGTGCCAGAAGATGATGGTCA
TGCCTTGTTAGCAGAAAGAATAGAGAAGTCACTAGTTGAACCGAAAGAAGATGAAAAAGGTGATGATGTTGATGACCCTGAAAACCAGAA
CTCAGCCCTGGCTGATACTGATGCCTCAGGAGGCTTAACCAAAGAGTCCCCAGATACAAATGGACCAAAACAAAAAGAGAAGGAGGATGC
CCAGGAAGTAGAATTGCAGGAAGGAAAAGTGCACAGTGAATCAGATAAAGCGATCACACCCCAAGCACAGGAGGAGTTACAGAAACAAGA
GAGAGAATCTGCAAAGTCAGAACTTACAGAATCTTAAAACATCATGCAGTTAAACTCATTGTCTGTTTGGAAGACCAGAATGTGAAGACA
AGTAGTAGAAGAAAATGAATGCTGCTGCTGAGACTGAAGACCAGTATTTCAGAACTTTGAGAATTGGAGAGCAGGCACATCAACTGATCT
CATTTCTAGAGAGCCCCTGACAATCCTGAGGCTTCATCAGGAGCTAGAGCCATTTAACATTTCCTCTTTCCAAGACCAACCTACAATTTT
CCCTTGATAACCATATAAATTCTGATTTAAGGTCCTAAATTCTTAACCTGGAACTGGAGTTGGCAATACCTAGTTCTGCTTCTGAAACTG
GAGTATCATTCTTTACATATTTATATGTATGTTTTAAGTAGTCCTCCTGTATCTATTGTATATTTTTTTCTTAATGTTTAAGGAAATGTG
CAGGATACTACATGCTTTTTGTATCACACAGTATATGATGGGGCATGTGCCATAGTGCAGGCTTGGGGAGCTTTAAGCCTCAGTTATATA
ACCCACGAAAAACAGAGCCTCCTAGATGTAACATTCCTGATCAAGGTACAATTCTTTAAAATTCACTAATGATTGAGGTCCATATTTAGT
GGTACTCTGAAATTGGTCACTTTCCTATTACACGGAGTGTGCTAAAACTAAAAAGCATTTTGAAACATACAGAATGTTCTATTGTCATTG
GGAAATTTTTCTTTCTAACCCAGTGGAGGTTAGAAAGAAGTTATATTCTGGTAGCAAATTAACTTTACATCCTTTTTCCTACTTGTTATG
GTTGTTTGGACCGATAAGTGTGCTTAATCCTGAGGCAAAGTAGTGAATATGTTTTATATGTTATGAAGAAAAGAATTGTTGTAAGTTTTT
GATTCTACTCTTATATGCTGGACTGCATTCACACATGGCATGAAATAAGTCAGGTTCTTTACAAATGGTATTTTGATAGATACTGGATTG
TGTTTGTGCCATATTTGTGCCATTCTTTTAAGAACAATGTTGCAACACATTCATTTGGATAAGTTGTGATTTGACGACTGATTTAAATAA

>55675_55675_1_MTHFD1L-AKAP12_MTHFD1L_chr6_151336829_ENST00000367321_AKAP12_chr6_151626882_ENST00000253332_length(amino acids)=2673AA_BP=1
MSGTAYQTKVPKAVTSRPAARRPPPSARHGRRVQCPLGAPGTRRKRQVLPAAAAAAAACSPGTRPAALGSRSSVSPENQPSRAMGTRLPL
VLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQEKNPAFK
PVLAIIQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVDGVTDINL
GKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLEAALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPEEI
PLTWIQPGTTVLNCSHDFLSGKVGCGSPRIHFGGLIEEDDVILLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVPSDIEISR
GQTPKAVDVLAKEIGLLADEIEIYGKSKAKVRLSVLERLKDQADGKYVLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSFACLRQPSQ
GPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAIDTRILHENTQTDKALYNRLVPLVNGVREFSEIQLARLKKLGINK
TDPSTLTEEEVSKFARLDIDPSTITWQRVLDTNDRFLRKITIGQGNTEKGHYRQAQFDIAVASEIMAVLALTDSLADMKARLGRMVVASD
KSGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGMEKFFNIK
CRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCELA
KRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQLLQKNGQLSTINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEE
EEVIVTEVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDIGFKKVFKFVGFKFTVKKDK
TEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSK
SAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPR
LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEP
AKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQ
VPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVK
SATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGIL
AGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRP
DGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEER
SPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEET
TEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKE
TDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVAD
FDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQ
YADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLE
HETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGA
HLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGI
LELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSD
ISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDA

--------------------------------------------------------------
>55675_55675_2_MTHFD1L-AKAP12_MTHFD1L_chr6_151336829_ENST00000367321_AKAP12_chr6_151626882_ENST00000402676_length(transcript)=10890nt_BP=2860nt
TGAGTCCCACTCCGCACCCCACCCTCTGTCTGGTACAGCTTACCAAACCAAAGTGCCCAAAGCCGTGACATCCCGGCCGGCGGCTCGCAG
GCCCCCGCCCTCCGCACGTCACGGCCGCCGGGTGCAGTGCCCCCTAGGGGCCCCTGGGACGAGGAGGAAGCGCCAGGTCCTTCCCGCCGC
CGCCGCCGCCGCCGCCGCCTGCTCCCCTGGCACGCGCCCCGCCGCCCTCGGCAGCCGCAGCTCCGTGTCCCCTGAGAACCAGCCGTCCCG
CGCCATGGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTG
TCGCGCTAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAG
CAGCTGCAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATT
GCAAGAAAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGC
TGAGGAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGATTATAGATGAAATCTTAAAGATCAATGA
AGATACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAACTTGTTTAGCAACAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGT
GGATGGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGGGATGCCCATGAATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGA
ACTTCTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATTTTGGTAGTGGGGGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCT
GTTCCAGAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAAACACGCCAGCTTCAAAGCAAGCTTCACGAGGCTGACATTGTGGTCCT
AGGCTCACCTAAGCCAGAAGAGATTCCCCTTACTTGGATACAACCAGGAACTACTGTTCTCAACTGCTCCCATGACTTCCTGTCAGGGAA
GGTTGGGTGTGGCTCTCCAAGAATACATTTTGGTGGACTCATTGAGGAAGATGATGTGATTCTCCTTGCTGCAGCTCTGCGAATTCAGAA
CATGGTCAGTAGTGGAAGGAGATGGCTTCGTGAACAGCAGCACAGGCGGTGGAGACTTCACTGCTTGAAACTTCAGCCTCTCTCCCCTGT
GCCAAGTGACATTGAGATTTCAAGAGGACAAACTCCAAAAGCTGTGGATGTCCTTGCCAAGGAGATTGGATTGCTTGCAGATGAAATTGA
AATCTATGGCAAAAGCAAAGCCAAAGTACGTTTGTCCGTGCTAGAAAGGTTAAAGGATCAAGCAGATGGAAAATACGTCTTAGTTGCTGG
GATCACACCCACCCCTCTTGGAGAAGGGAAGAGCACAGTCACCATCGGGCTTGTGCAGGCTCTGACCGCACACCTGAATGTCAACTCCTT
TGCCTGCTTGAGGCAGCCTTCCCAAGGACCGACGTTTGGAGTGAAAGGAGGAGCCGCGGGTGGTGGATATGCCCAGGTCATCCCCATGGA
GGAGTTCAACCTTCACTTGACTGGAGACATCCACGCCATCACCGCTGCCAATAACTTGCTGGCTGCCGCCATCGACACGAGGATTCTTCA
TGAAAACACGCAAACAGATAAGGCTCTGTATAATCGGCTGGTTCCTTTAGTGAATGGTGTCAGAGAATTTTCAGAAATTCAGCTTGCTCG
GCTAAAAAAACTGGGAATAAATAAGACTGATCCGAGCACACTGACAGAAGAGGAAGTGAGTAAATTTGCCCGTCTCGACATCGACCCATC
TACCATCACGTGGCAGAGAGTATTGGATACAAATGACCGATTTCTACGAAAAATAACCATCGGGCAGGGAAACACAGAGAAGGGCCATTA
CCGGCAGGCGCAGTTTGACATCGCAGTGGCCAGCGAGATCATGGCGGTGCTGGCCCTGACGGACAGCCTCGCAGACATGAAGGCACGGCT
GGGAAGGATGGTGGTGGCCAGTGACAAAAGCGGGCAGCCTGTGACAGCAGATGATTTGGGGGTGACAGGTGCTTTGACAGTTTTGATGAA
AGATGCAATAAAACCAAACCTGATGCAGACCCTGGAAGGGACACCTGTGTTCGTGCATGCGGGCCCTTTTGCTAACATTGCTCACGGCAA
CTCTTCAGTGTTGGCTGATAAAATTGCCCTGAAACTGGTTGGTGAAGAAGGATTTGTAGTGACCGAAGCTGGCTTTGGTGCTGACATCGG
AATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGAT
GCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTG
TAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGA
GATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGT
GGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGCTCCTACAGAAGAATGGTCA
GCTGTCCACCATCAATGGCGTAGCTGAGCAAGATGAGCTCAGCCTCCAGGAGGGTGACCTAAATGGCCAGAAAGGAGCCCTGAACGGTCA
AGGAGCCCTAAACAGCCAGGAGGAAGAAGAAGTCATTGTCACAGAGGTTGGACAGAGAGACTCTGAAGATGTGAGCAAAAGAGACTCCGA
TAAAGAGATGGCTACTAAGTCAGCGGTTGTTCACGACATCACAGATGATGGGCAGGAGGAGACACCCGAAATAATCGAACAGATTCCTTC
TTCAGAAAGCAATTTAGAAGAGCTAACACAACCCACTGAGTCCCAGGCTAATGATATTGGATTTAAGAAGGTGTTTAAGTTTGTTGGCTT
TAAATTCACTGTGAAAAAGGATAAGACAGAGAAGCCTGACACTGTCCAGCTACTCACTGTGAAGAAAGATGAAGGGGAGGGAGCAGCAGG
GGCTGGCGACCACAAGGACCCCAGCCTTGGGGCTGGAGAAGCAGCATCCAAAGAAAGCGAACCCAAACAATCTACAGAGAAACCCGAAGA
GACCCTGAAGCGTGAGCAAAGCCACGCAGAAATTTCTCCCCCAGCCGAATCTGGCCAAGCAGTGGAGGAATGCAAAGAGGAAGGAGAAGA
GAAACAAGAAAAAGAACCTAGCAAGTCTGCAGAATCTCCGACTAGTCCCGTGACCAGTGAAACAGGATCAACCTTCAAAAAATTCTTCAC
TCAAGGTTGGGCCGGCTGGCGCAAAAAGACCAGTTTCAGGAAGCCGAAGGAGGATGAAGTGGAAGCTTCAGAGAAGAAAAAGGAACAAGA
GCCAGAAAAAGTAGACACAGAAGAAGACGGAAAGGCAGAGGTTGCCTCCGAGAAACTGACCGCCTCCGAGCAAGCCCACCCACAGGAGCC
GGCAGAAAGTGCCCACGAGCCCCGGTTATCAGCTGAATATGAGAAAGTTGAGCTGCCCTCAGAGGAGCAAGTCAGTGGCTCGCAGGGACC
TTCTGAAGAGAAACCTGCTCCGTTGGCGACAGAAGTGTTTGATGAGAAAATAGAAGTCCACCAAGAAGAGGTTGTGGCCGAAGTCCACGT
CAGCACCGTGGAGGAGAGAACCGAAGAGCAGAAAACGGAGGTGGAAGAAACAGCAGGGTCTGTGCCAGCTGAAGAATTGGTTGAAATGGA
TGCAGAACCTCAGGAAGCTGAACCTGCCAAGGAGCTGGTGAAGCTCAAAGAAACGTGTGTTTCCGGAGAGGACCCTACACAGGGAGCTGA
CCTCAGTCCTGATGAGAAGGTGCTGTCCAAACCCCCCGAAGGCGTTGTGAGTGAGGTGGAAATGCTGTCATCACAGGAGAGAATGAAGGT
GCAGGGAAGTCCACTAAAGAAGCTTTTTACCAGCACTGGCTTAAAAAAGCTTTCTGGAAAGAAACAGAAAGGGAAAAGAGGAGGAGGAGA
CGAGGAATCAGGGGAGCACACTCAGGTTCCAGCCGATTCTCCGGACAGCCAGGAGGAGCAAAAGGGCGAGAGCTCTGCCTCATCCCCTGA
GGAGCCCGAGGAGATCACGTGTCTGGAAAAGGGCTTAGCCGAGGTGCAGCAGGATGGGGAAGCTGAAGAAGGAGCTACTTCCGATGGAGA
GAAAAAAAGAGAAGGTGTCACTCCCTGGGCATCATTCAAAAAGATGGTGACGCCCAAGAAGCGTGTTAGACGGCCTTCGGAAAGTGATAA
AGAAGATGAGCTGGACAAGGTCAAGAGCGCTACCTTGTCTTCCACCGAGAGCACAGCCTCTGAAATGCAAGAAGAAATGAAAGGGAGCGT
GGAAGAGCCAAAGCCGGAAGAACCAAAGCGCAAGGTGGATACCTCAGTATCTTGGGAAGCTTTAATTTGTGTGGGATCATCCAAGAAAAG
AGCAAGGAGAGGGTCCTCTTCTGATGAGGAAGGGGGACCAAAAGCAATGGGAGGAGACCACCAGAAAGCTGATGAGGCCGGAAAAGACAA
AGAGACGGGGACAGACGGGATCCTTGCTGGTTCCCAAGAACATGATCCAGGGCAGGGAAGTTCCTCCCCGGAGCAAGCTGGAAGCCCTAC
CGAAGGGGAGGGCGTTTCCACCTGGGAGTCATTTAAAAGGTTAGTCACGCCAAGAAAAAAATCAAAGTCCAAGCTGGAAGAGAAAAGCGA
AGACTCCATAGCTGGGTCTGGTGTAGAACATTCCACTCCAGACACTGAACCCGGTAAAGAAGAATCCTGGGTCTCAATCAAGAAGTTTAT
TCCTGGACGAAGGAAGAAAAGGCCAGATGGGAAACAAGAACAAGCCCCTGTTGAAGACGCAGGGCCAACAGGGGCCAACGAAGATGACTC
TGATGTCCCGGCCGTGGTCCCTCTGTCTGAGTATGATGCTGTAGAAAGGGAGAAAATGGAGGCACAGCAAGCCCAAAAAAGCGCAGAGCA
GCCCGAGCAGAAGGCAGCCACTGAGGTGTCCAAGGAGCTCAGCGAGAGTCAGGTTCATATGATGGCAGCAGCTGTCGCTGACGGGACGAG
GGCAGCTACCATTATTGAAGAAAGGTCTCCTTCTTGGATATCTGCTTCAGTGACAGAACCTCTTGAACAAGTAGAAGCTGAAGCCGCACT
GTTAACTGAGGAGGTATTGGAAAGAGAAGTAATTGCAGAAGAAGAACCCCCCACGGTTACTGAACCTCTGCCAGAGAACAGAGAGGCCCG
GGGCGACACGGTCGTTAGTGAGGCGGAATTGACCCCCGAAGCTGTGACAGCTGCAGAAACTGCAGGGCCATTGGGTGCCGAAGAAGGAAC
CGAAGCATCTGCTGCTGAAGAGACCACAGAAATGGTGTCAGCAGTCTCCCAGTTAACCGACTCCCCAGACACCACAGAGGAGGCCACTCC
GGTGCAGGAGGTGGAAGGTGGCGTACCTGACATAGAAGAGCAAGAGAGGCGGACTCAAGAGGTCCTCCAGGCAGTGGCAGAAAAAGTGAA
AGAGGAATCCCAGCTGCCTGGCACCGGTGGGCCAGAAGATGTGCTTCAGCCTGTGCAGAGAGCAGAGGCAGAAAGACCAGAAGAGCAGGC
TGAAGCGTCGGGTCTGAAGAAAGAGACGGATGTAGTGTTGAAAGTAGATGCTCAGGAGGCAAAAACTGAGCCTTTTACACAAGGGAAGGT
GGTGGGGCAGACCACCCCAGAAAGCTTTGAAAAAGCTCCTCAAGTCACAGAGAGCATAGAGTCCAGTGAGCTTGTAACCACTTGTCAAGC
CGAAACCTTAGCTGGGGTAAAATCACAGGAGATGGTGATGGAACAGGCTATCCCCCCTGACTCGGTGGAAACCCCTACAGACAGTGAGAC
TGATGGAAGCACCCCCGTAGCCGACTTTGACGCACCAGGCACAACCCAGAAAGACGAGATTGTGGAAATCCATGAGGAGAATGAGGTCGC
ATCTGGTACCCAGTCAGGGGGCACAGAAGCAGAGGCAGTTCCTGCACAGAAAGAGAGGCCTCCAGCACCTTCCAGTTTTGTGTTCCAGGA
AGAAACTAAAGAACAATCAAAGATGGAAGACACTCTAGAGCATACAGATAAAGAGGTGTCAGTGGAAACTGTATCCATTCTGTCAAAGAC
TGAGGGGACTCAAGAGGCTGACCAGTATGCTGATGAGAAAACCAAAGACGTACCATTTTTCGAAGGACTTGAGGGGTCTATAGACACAGG
CATAACAGTCAGTCGGGAAAAGGTCACTGAAGTTGCCCTTAAAGGTGAAGGGACAGAAGAAGCTGAATGTAAAAAGGATGATGCTCTTGA
ACTGCAGAGTCACGCTAAGTCTCCTCCATCCCCCGTGGAGAGAGAGATGGTAGTTCAAGTCGAAAGGGAGAAAACAGAAGCAGAGCCAAC
CCATGTGAATGAAGAGAAGCTTGAGCACGAAACAGCTGTTACCGTATCTGAAGAGGTCAGTAAGCAGCTCCTCCAGACAGTGAATGTGCC
CATCATAGATGGGGCAAAGGAAGTCAGCAGTTTGGAAGGAAGCCCTCCTCCCTGCCTAGGTCAAGAGGAGGCAGTATGCACCAAAATTCA
AGTTCAGAGCTCTGAGGCATCATTCACTCTAACAGCGGCTGCAGAGGAGGAAAAGGTCTTAGGAGAAACTGCCAACATTTTAGAAACAGG
TGAAACGTTGGAGCCTGCAGGTGCACATTTAGTTCTGGAAGAGAAATCCTCTGAAAAAAATGAAGACTTTGCCGCTCATCCAGGGGAAGA
TGCTGTGCCCACAGGGCCCGACTGTCAGGCAAAATCGACACCAGTGATAGTATCTGCTACTACCAAGAAAGGCTTAAGTTCCGACCTGGA
AGGAGAGAAAACCACATCACTGAAGTGGAAGTCAGATGAAGTCGATGAGCAGGTTGCTTGCCAGGAGGTCAAAGTGAGTGTAGCAATTGA
GGATTTAGAGCCTGAAAATGGGATTTTGGAACTTGAGACCAAAAGCAGTAAACTTGTCCAAAACATCATCCAGACAGCCGTTGACCAGTT
TGTACGTACAGAAGAAACAGCCACCGAAATGTTGACGTCTGAGTTACAGACACAAGCTCACGTGATAAAAGCTGACAGCCAGGACGCTGG
ACAGGAAACGGAGAAAGAAGGAGAGGAACCTCAGGCCTCTGCACAGGATGAAACACCAATTACTTCAGCCAAAGAGGAGTCAGAGTCAAC
CGCAGTGGGACAAGCACATTCTGATATTTCCAAAGACATGAGTGAAGCCTCAGAAAAGACCATGACTGTTGAGGTAGAAGGTTCCACTGT
AAATGATCAGCAGCTGGAAGAGGTCGTCCTCCCATCTGAGGAAGAGGGAGGTGGAGCTGGAACAAAGTCTGTGCCAGAAGATGATGGTCA
TGCCTTGTTAGCAGAAAGAATAGAGAAGTCACTAGTTGAACCGAAAGAAGATGAAAAAGGTGATGATGTTGATGACCCTGAAAACCAGAA
CTCAGCCCTGGCTGATACTGATGCCTCAGGAGGCTTAACCAAAGAGTCCCCAGATACAAATGGACCAAAACAAAAAGAGAAGGAGGATGC
CCAGGAAGTAGAATTGCAGGAAGGAAAAGTGCACAGTGAATCAGATAAAGCGATCACACCCCAAGCACAGGAGGAGTTACAGAAACAAGA
GAGAGAATCTGCAAAGTCAGAACTTACAGAATCTTAAAACATCATGCAGTTAAACTCATTGTCTGTTTGGAAGACCAGAATGTGAAGACA
AGTAGTAGAAGAAAATGAATGCTGCTGCTGAGACTGAAGACCAGTATTTCAGAACTTTGAGAATTGGAGAGCAGGCACATCAACTGATCT
CATTTCTAGAGAGCCCCTGACAATCCTGAGGCTTCATCAGGAGCTAGAGCCATTTAACATTTCCTCTTTCCAAGACCAACCTACAATTTT
CCCTTGATAACCATATAAATTCTGATTTAAGGTCCTAAATTCTTAACCTGGAACTGGAGTTGGCAATACCTAGTTCTGCTTCTGAAACTG
GAGTATCATTCTTTACATATTTATATGTATGTTTTAAGTAGTCCTCCTGTATCTATTGTATATTTTTTTCTTAATGTTTAAGGAAATGTG
CAGGATACTACATGCTTTTTGTATCACACAGTATATGATGGGGCATGTGCCATAGTGCAGGCTTGGGGAGCTTTAAGCCTCAGTTATATA
ACCCACGAAAAACAGAGCCTCCTAGATGTAACATTCCTGATCAAGGTACAATTCTTTAAAATTCACTAATGATTGAGGTCCATATTTAGT
GGTACTCTGAAATTGGTCACTTTCCTATTACACGGAGTGTGCTAAAACTAAAAAGCATTTTGAAACATACAGAATGTTCTATTGTCATTG
GGAAATTTTTCTTTCTAACCCAGTGGAGGTTAGAAAGAAGTTATATTCTGGTAGCAAATTAACTTTACATCCTTTTTCCTACTTGTTATG
GTTGTTTGGACCGATAAGTGTGCTTAATCCTGAGGCAAAGTAGTGAATATGTTTTATATGTTATGAAGAAAAGAATTGTTGTAAGTTTTT
GATTCTACTCTTATATGCTGGACTGCATTCACACATGGCATGAAATAAGTCAGGTTCTTTACAAATGGTATTTTGATAGATACTGGATTG
TGTTTGTGCCATATTTGTGCCATTCTTTTAAGAACAATGTTGCAACACATTCATTTGGATAAGTTGTGATTTGACGACTGATTTAAATAA
AATATTTGCTTCACTTAGATTTGCTGGTTTTATTAGATACCAGGAAGCCTGGGACATATGTGTACCACATTAGAATTCTAAAGATAATGA
TTGATAAGCTAGAACTTTCTGATGTAGTCATTACATGAAACCCCTTGTCACTGGTTTGTGTGTTCAGAGGAAGCCATGGCCGAGATAGCT
TTCCTGAAATAAACCAGTAGCTTTTCAGATTGACGTTCTTGCTACAATTGTACCATCTGGTAATTCCTGAAAATGTCAATTTTTTTGTGT
TAATATTTTTGGTTTCAAACAATAACAAATGTCTCTAGAAAGAAATTTTAAGAAAGCTTAATTAATAGTAAAAATGCCTTTCCTGAAATA
ATCTTGGAAAATTTTTTAAATGTCAAAATGATGAGTCATGCTAATACATTGAGGGTTTGTTTTTTTGTTTGTTTGTTTGTTTGTTTTTGA
GACAGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGCACGATCTCAGCTCACCGCAACCTCCACCTCCCGGATTCCAGCGATTCT
CCTGCCTCAGCCTACATTAAGGGTTTTGTCAGACAATTGTCACACGAAGAATAGTGTCACTTATCTACTCTTGACACACAGAACTGGCCT
GGCATATAGCTTTCCAGATTTTACTCAAACTTGGTACTCCAGTTTGAAAATTTAAATTTTGACTGCTGATTAGCTGGAAAGCCTAGTTTT
AATGGAAAGAAAGTTTGCTTTTAAAACTGAAAGTAGTTTCTTTTTGCTAACAAATCTAACTTCATACATAATTGGCCATATTAGTAAAAC
ACCTCATGATAGCAGTGTATATATAGTCTTGTTTGTAGTTGGAAGTCATCTTTTAGGAGTTATTCTCAAATATATATAATAGCTACCCAT
GCATCATTATTAAAATCCCCAAATTCAAAAAACCTCTGATATATATATATAATTTTTTTTTTTTTTTTTTTTTGGCCAACTGAGATTGAA
ATCCAAGTGCTGGTTTCTAGTTCTGAACATCAACTAAAGAGTTTTGGAAATGACAGCAATTTATAACAAGTTCATATTGACTTCCTCTCT
ATGGCAGGAAGACATTCTGTGCTGTTTTGAACAGATTAAAGATTTGTGTAGTTTGTGGGAAATTGACGTTTTTGTTTAAATTCCACCCGC
GTTTGTCTTTTCCTACCACCTGTGGCCAGGTGCTCGCTGGCCATCACAGTTGCGATTCCATGAGTAGCTGCTTTATGACTGCTTTTTGTA
CTATCTGGATGTGCCCAGAGTTACTTCTGTACAAGCTCTGTATCTATGTCCGTTGAGAACATTATTTTAACAAGAAGAACACCAACAGTA
GCATGAAATATAATACTGTTTTATAATTCTAAAGCTGCTGTTAATTTATGAAGTACATAATAATCTAATGTAAACTGCAGAAGTCAGAGC
AAGTGCCTACATTTTGTTATTTTTGGCATTACTACAGAGCCATGTACAATAGAAAGCAATGCAAGACTTGTAAACTCTCACCACTTCTTG
TAATATCAAATGTTCCCCCTCAGGTTATTTTGCTTATGGTACCCATGAGTTGCCTCTCTCTGTACATAGATAAATTGTTCCAATATTTTC
CTTTGATGTTTGGAACTACAGATAGTCAAGGGCTGGAAATTTTAGTTTTCAATATAAGCTTCCAGCTTAGCAATTACCTCTAGTCGAAGA
CAATATTTGATTCCTAGTTCTGTTTGGGGCAAATTTTCATTTATCTAAATAAAATGCAATCTAATTAAATGCCATGGATTTTCTTTCTGT

>55675_55675_2_MTHFD1L-AKAP12_MTHFD1L_chr6_151336829_ENST00000367321_AKAP12_chr6_151626882_ENST00000402676_length(amino acids)=2673AA_BP=1
MSGTAYQTKVPKAVTSRPAARRPPPSARHGRRVQCPLGAPGTRRKRQVLPAAAAAAAACSPGTRPAALGSRSSVSPENQPSRAMGTRLPL
VLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQEKNPAFK
PVLAIIQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVDGVTDINL
GKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLEAALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPEEI
PLTWIQPGTTVLNCSHDFLSGKVGCGSPRIHFGGLIEEDDVILLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVPSDIEISR
GQTPKAVDVLAKEIGLLADEIEIYGKSKAKVRLSVLERLKDQADGKYVLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSFACLRQPSQ
GPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAIDTRILHENTQTDKALYNRLVPLVNGVREFSEIQLARLKKLGINK
TDPSTLTEEEVSKFARLDIDPSTITWQRVLDTNDRFLRKITIGQGNTEKGHYRQAQFDIAVASEIMAVLALTDSLADMKARLGRMVVASD
KSGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGMEKFFNIK
CRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCELA
KRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQLLQKNGQLSTINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEE
EEVIVTEVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDIGFKKVFKFVGFKFTVKKDK
TEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSK
SAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPR
LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEP
AKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQ
VPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVK
SATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGIL
AGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRP
DGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEER
SPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEET
TEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKE
TDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVAD
FDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQ
YADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLE
HETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGA
HLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGI
LELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSD
ISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDA

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Fusion Gene PPI Analysis for MTHFD1L-AKAP12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MTHFD1L-AKAP12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MTHFD1L-AKAP12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource