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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MTHFD1L-IFT81 (FusionGDB2 ID:55680)

Fusion Gene Summary for MTHFD1L-IFT81

check button Fusion gene summary
Fusion gene informationFusion gene name: MTHFD1L-IFT81
Fusion gene ID: 55680
HgeneTgene
Gene symbol

MTHFD1L

IFT81

Gene ID

25902

28981

Gene namemethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 likeintraflagellar transport 81
SynonymsFTHFSDC1|MTC1THFS|dJ292B18.2CDV-1|CDV-1R|CDV1|CDV1R|DV1|SRTD19
Cytomap

6q25.1

12q24.11

Type of geneprotein-codingprotein-coding
Descriptionmonofunctional C1-tetrahydrofolate synthase, mitochondrial10-formyl-THF synthetaseformyltetrahydrofolate synthetase domain containing 1intraflagellar transport protein 81 homologcarnitine deficiency-associated gene expressed in ventricle 1carnitine deficiency-associated protein expressed in ventricle 1
Modification date2020031320200313
UniProtAcc

Q6UB35

Q8WYA0

Ensembl transtripts involved in fusion geneENST00000367307, ENST00000367321, 
ENST00000478643, 		ENST00000549009, 
ENST00000242591, ENST00000361948, 
ENST00000552912, 
Fusion gene scores* DoF score11 X 14 X 5=7706 X 8 X 8=384
# samples 1312
** MAII scorelog2(13/770*10)=-2.56634682255381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/384*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MTHFD1L [Title/Abstract] AND IFT81 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMTHFD1L(151198962)-IFT81(110600724), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMTHFD1L

GO:0006760

folic acid-containing compound metabolic process

12937168

HgeneMTHFD1L

GO:0009257

10-formyltetrahydrofolate biosynthetic process

12937168

HgeneMTHFD1L

GO:0015942

formate metabolic process

16171773


check buttonFusion gene breakpoints across MTHFD1L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IFT81 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A1L4-01AMTHFD1Lchr6

151198962

-IFT81chr12

110600724

+
ChimerDB4SARCTCGA-DX-A1L4-01AMTHFD1Lchr6

151198962

+IFT81chr12

110600724

+


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Fusion Gene ORF analysis for MTHFD1L-IFT81

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000367307ENST00000549009MTHFD1Lchr6

151198962

+IFT81chr12

110600724

+
5CDS-3UTRENST00000367321ENST00000549009MTHFD1Lchr6

151198962

+IFT81chr12

110600724

+
In-frameENST00000367307ENST00000242591MTHFD1Lchr6

151198962

+IFT81chr12

110600724

+
In-frameENST00000367307ENST00000361948MTHFD1Lchr6

151198962

+IFT81chr12

110600724

+
In-frameENST00000367307ENST00000552912MTHFD1Lchr6

151198962

+IFT81chr12

110600724

+
In-frameENST00000367321ENST00000242591MTHFD1Lchr6

151198962

+IFT81chr12

110600724

+
In-frameENST00000367321ENST00000361948MTHFD1Lchr6

151198962

+IFT81chr12

110600724

+
In-frameENST00000367321ENST00000552912MTHFD1Lchr6

151198962

+IFT81chr12

110600724

+
intron-3CDSENST00000478643ENST00000242591MTHFD1Lchr6

151198962

+IFT81chr12

110600724

+
intron-3CDSENST00000478643ENST00000361948MTHFD1Lchr6

151198962

+IFT81chr12

110600724

+
intron-3CDSENST00000478643ENST00000552912MTHFD1Lchr6

151198962

+IFT81chr12

110600724

+
intron-3UTRENST00000478643ENST00000549009MTHFD1Lchr6

151198962

+IFT81chr12

110600724

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367321MTHFD1Lchr6151198962+ENST00000552912IFT81chr12110600724+2230691251680551
ENST00000367321MTHFD1Lchr6151198962+ENST00000242591IFT81chr12110600724+2252691251680551
ENST00000367321MTHFD1Lchr6151198962+ENST00000361948IFT81chr12110600724+215069125945306
ENST00000367307MTHFD1Lchr6151198962+ENST00000552912IFT81chr12110600724+2224685191674551
ENST00000367307MTHFD1Lchr6151198962+ENST00000242591IFT81chr12110600724+2246685191674551
ENST00000367307MTHFD1Lchr6151198962+ENST00000361948IFT81chr12110600724+214468519939306

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367321ENST00000552912MTHFD1Lchr6151198962+IFT81chr12110600724+0.0010247780.9989753
ENST00000367321ENST00000242591MTHFD1Lchr6151198962+IFT81chr12110600724+0.0009260210.999074
ENST00000367321ENST00000361948MTHFD1Lchr6151198962+IFT81chr12110600724+0.0086994930.9913005
ENST00000367307ENST00000552912MTHFD1Lchr6151198962+IFT81chr12110600724+0.0010055830.9989944
ENST00000367307ENST00000242591MTHFD1Lchr6151198962+IFT81chr12110600724+0.0009091110.9990909
ENST00000367307ENST00000361948MTHFD1Lchr6151198962+IFT81chr12110600724+0.0077471020.9922529

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Fusion Genomic Features for MTHFD1L-IFT81


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MTHFD1L-IFT81


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:151198962/chr12:110600724)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTHFD1L

Q6UB35

IFT81

Q8WYA0

FUNCTION: May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. {ECO:0000250, ECO:0000269|PubMed:16171773}.FUNCTION: Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region (PubMed:23990561). Required for ciliogenesis (PubMed:27666822, PubMed:23990561). Required for proper regulation of SHH signaling (PubMed:27666822). {ECO:0000269|PubMed:23990561, ECO:0000269|PubMed:27666822}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTHFD1Lchr6:151198962chr12:110600724ENST00000367307+4834_42139276.0Compositional biasNote=Poly-Gly
HgeneMTHFD1Lchr6:151198962chr12:110600724ENST00000367321+42834_42139932.6666666666666Compositional biasNote=Poly-Gly
TgeneIFT81chr6:151198962chr12:110600724ENST00000242591919416_456347677.0Coiled coilOntology_term=ECO:0000255
TgeneIFT81chr6:151198962chr12:110600724ENST00000242591919490_622347677.0Coiled coilOntology_term=ECO:0000255
TgeneIFT81chr6:151198962chr12:110600724ENST00000361948912416_456347432.0Coiled coilOntology_term=ECO:0000255
TgeneIFT81chr6:151198962chr12:110600724ENST00000361948912490_622347432.0Coiled coilOntology_term=ECO:0000255
TgeneIFT81chr6:151198962chr12:110600724ENST00000552912919416_456347677.0Coiled coilOntology_term=ECO:0000255
TgeneIFT81chr6:151198962chr12:110600724ENST00000552912919490_622347677.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTHFD1Lchr6:151198962chr12:110600724ENST00000367307+48423_430139276.0Nucleotide bindingATP
HgeneMTHFD1Lchr6:151198962chr12:110600724ENST00000367321+428423_430139932.6666666666666Nucleotide bindingATP
HgeneMTHFD1Lchr6:151198962chr12:110600724ENST00000367307+4831_348139276.0RegionNote=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase
HgeneMTHFD1Lchr6:151198962chr12:110600724ENST00000367307+48349_978139276.0RegionNote=Formyltetrahydrofolate synthetase
HgeneMTHFD1Lchr6:151198962chr12:110600724ENST00000367321+42831_348139932.6666666666666RegionNote=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase
HgeneMTHFD1Lchr6:151198962chr12:110600724ENST00000367321+428349_978139932.6666666666666RegionNote=Formyltetrahydrofolate synthetase
TgeneIFT81chr6:151198962chr12:110600724ENST00000242591919132_258347677.0Coiled coilOntology_term=ECO:0000255
TgeneIFT81chr6:151198962chr12:110600724ENST00000242591919306_389347677.0Coiled coilOntology_term=ECO:0000255
TgeneIFT81chr6:151198962chr12:110600724ENST00000361948912132_258347432.0Coiled coilOntology_term=ECO:0000255
TgeneIFT81chr6:151198962chr12:110600724ENST00000361948912306_389347432.0Coiled coilOntology_term=ECO:0000255
TgeneIFT81chr6:151198962chr12:110600724ENST00000552912919132_258347677.0Coiled coilOntology_term=ECO:0000255
TgeneIFT81chr6:151198962chr12:110600724ENST00000552912919306_389347677.0Coiled coilOntology_term=ECO:0000255
TgeneIFT81chr6:151198962chr12:110600724ENST000002425919192_121347677.0RegionNote=CH (calponin-homology)-like region
TgeneIFT81chr6:151198962chr12:110600724ENST000003619489122_121347432.0RegionNote=CH (calponin-homology)-like region
TgeneIFT81chr6:151198962chr12:110600724ENST000005529129192_121347677.0RegionNote=CH (calponin-homology)-like region


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Fusion Gene Sequence for MTHFD1L-IFT81


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>55680_55680_1_MTHFD1L-IFT81_MTHFD1L_chr6_151198962_ENST00000367307_IFT81_chr12_110600724_ENST00000242591_length(transcript)=2246nt_BP=685nt
CCACTCCGCACCCCACCCTCTGTCTGGTACAGCTTACCAAACCAAAGTGCCCAAAGCCGTGACATCCCGGCCGGCGGCTCGCAGGCCCCC
GCCCTCCGCACGTCACGGCCGCCGGGTGCAGTGCCCCCTAGGGGCCCCTGGGACGAGGAGGAAGCGCCAGGTCCTTCCCGCCGCCGCCGC
CGCCGCCGCCGCCTGCTCCCCTGGCACGCGCCCCGCCGCCCTCGGCAGCCGCAGCTCCGTGTCCCCTGAGAACCAGCCGTCCCGCGCCAT
GGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTGTCGCGC
TAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAGCAGCTG
CAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATTGCAAGA
AAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGCTGAGGA
GGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGGCATCTATCATTTCCCGTAAAAAAGAAGCCAAAGC
TGAGGAACTTCAGGAGGCCAAGGAGAAGTTAGCCAGCCTAGAGAGAGAAGCATCAGTAAAGAGAAATCAGACCCGTGAATTTGATGGTAC
TGAAGTTTTAAAGGGAGATGAGTTCAAACGATATGTCAATAAACTTCGAAGCAAGAGTACAGTTTTCAAAAAGAAGCATCAGATAATAGC
TGAACTTAAAGCTGAATTCGGTCTTTTGCAGAGGACTGAAGAACTTCTTAAGCAACGTCATGAAAATATTCAACAACAACTGCAAACTAT
GGAGGAGAAAAAGGGTATATCTGGATATAGTTACACCCAAGAAGAGCTAGAAAGAGTATCTGCACTGAAGAGTGAAGTTGATGAAATGAA
AGGACGAACATTGGATGATATGTCTGAAATGGTGAAAAAACTGTATTCATTGGTATCTGAAAAGAAGTCAGCTCTTGCCTCAGTTATAAA
AGAGCTACGACAGTTGCGTCAAAAATATCAAGAACTGACCCAGGAGTGTGATGAAAAGAAATCCCAGTATGATAGCTGTGCAGCAGGCCT
CGAAAGCAATCGGTCCAAATTAGAACAGGAAGTTAGAAGACTCCGTGAAGAATGTCTTCAAGAAGAAAGTAGATACCATTATACAAATTG
TATGATTAAGAACCTAGAAGTTCAACTTCGTCGTGCTACTGATGAGATGAAGGCATATATCTCTTCTGATCAACAAGAAAAAAGAAAGGC
AATTAGGGAACAGTATACCAAAAATACTGCTGAACAAGAAAACCTTGGAAAGAAACTTCGGGAAAAACAAAAAGTTATACGAGAAAGTCA
TGGTCCAAATATGAAACAAGCAAAAATGTGGCGTGATTTGGAACAATTAATGGAATGTAAGAAACAGTGCTTTCTGAAACAACAAAGCCA
AACTTCCATTGGTCAGGTAATTCAGGAGGGTGGGGAGGACCGGCTAATACTGTGAATTCTTGTGTCATCGTTTGGGGTTTTACTTGATAC
CACTAGCTATAAGCCTAATCTCATAATGTATTTCTTTTTTGAAACTGATTTGTATAGCATTTTGTTTTCAGAAGAGCCATTCTTTATTAA
GTTTTCATAGAAAATAATGTTAAGGTAGATTTAGTTTGAATGTTTTTTCATATGAAAAAGAGGCTTTTATTCTTTTCCATAGTTTAGACA
TCACTGGCGTCTTCTGAGTTTTATGAGACAGGAAACTAAGTTTACTATCTGTAAATGTAAACATATGTCCATTAAGAAACATGTAGTTTT
TTTTTAGAATGTAATAACCCAGTGGCTTACTGTTTTTCTTAATCTCTTTTAAAAAAACTTTAGAAGAATCTTTTAGGAACTAATATCTCT
TGTTCTGAAGAAACATTTATCTGACGTTCAGCAGTTCCTACAGTTTTACTTCAGTTTATTTTTCTTCTGTAAAATGCAAGAAAATTTAAT

>55680_55680_1_MTHFD1L-IFT81_MTHFD1L_chr6_151198962_ENST00000367307_IFT81_chr12_110600724_ENST00000242591_length(amino acids)=551AA_BP=222
MSGTAYQTKVPKAVTSRPAARRPPPSARHGRRVQCPLGAPGTRRKRQVLPAAAAAAAACSPGTRPAALGSRSSVSPENQPSRAMGTRLPL
VLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQEKNPAFK
PVLAIIQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGD
EFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDD
MSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLE
VQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQV

--------------------------------------------------------------
>55680_55680_2_MTHFD1L-IFT81_MTHFD1L_chr6_151198962_ENST00000367307_IFT81_chr12_110600724_ENST00000361948_length(transcript)=2144nt_BP=685nt
CCACTCCGCACCCCACCCTCTGTCTGGTACAGCTTACCAAACCAAAGTGCCCAAAGCCGTGACATCCCGGCCGGCGGCTCGCAGGCCCCC
GCCCTCCGCACGTCACGGCCGCCGGGTGCAGTGCCCCCTAGGGGCCCCTGGGACGAGGAGGAAGCGCCAGGTCCTTCCCGCCGCCGCCGC
CGCCGCCGCCGCCTGCTCCCCTGGCACGCGCCCCGCCGCCCTCGGCAGCCGCAGCTCCGTGTCCCCTGAGAACCAGCCGTCCCGCGCCAT
GGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTGTCGCGC
TAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAGCAGCTG
CAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATTGCAAGA
AAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGCTGAGGA
GGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGGCATCTATCATTTCCCGTAAAAAAGAAGCCAAAGC
TGAGGAACTTCAGGAGGCCAAGGAGAAGTTAGCCAGCCTAGAGAGAGAAGCATCAGTAAAGAGAAATCAGACCCGTGAATTTGATGGTAC
TGAAGTTTTAAAGGGAGATGAGAGACAGGATCTCACTCTGTCACCCAGGCTGGAGTGCGGTGGTGTGATCATGGCTTACTGCAGCCTGAA
ACTCCTAGGCTCAAGTGATCCTCCTACCTCAGCCTCCTGAGAAGCTCGGACTACAGGCACGAGCCACCATGCCCAGCTAATTTTCTTTTT
TTGTTTTGTTTTGTAGAGATGTGGTCTCACTATGTTTCCCAGGCTGGTCTTAAACTCCCGGCCTCAAGCAGTCCTCCCACTTCGGCCTCC
TGAAGTGTTAGGATTACAGGCGTGAGCCTGCGCCTGGCTGTAATTACTATACCCAGTTTTTACAGATAAAGGATCTGAGACATGCAGAGG
TTTTAAGCTGACTTGCCTGACACCCCATTGCTAGTAAGTAGTAGAACCAGGAGTTGGATTTAGCAGTCTGGCTGTAGAGTCATCAATAGT
TTGCACATGACAGAAAGCTGGAAGAAATAGTCAACCTGAAACACATGATGGAATTATAATTCAGAATCATCTTGGTAGATAGGGGCACTG
TGCTTAAACAAAATGCCATTAATGGGATTATAATAAATATAATGTGGTAGAATTCAAGTTTTGTTTGCCAATTCAACACATCATCTGTTA
CTAACGCAGCTTTAAAAAATGCATAAACGATTATACTACATTAATTTTTTTAAAAAGTATCCTGTTTATGGTCTGATTATGCCTGGAGTA
TTATTTTATATTTTTGACTTCATGTTTTAAGAGACAATCATGCCAGAGTCCCACATGAGGGTGACTAAAATGGACAAAAAGTCTGGAAAC
TTTCATATCAATAATTGATTATGTATTAACTGAAACAAAAGACTAGAGAAAGACACAGTGGGAATTGATTATGTATTAACTGAGGAATAA
AAGACTGAAGAAAGACATAATAAATAGTTAAAGGATTATGGAAAAGATGGTGTTCAGAAAAAAATTAACATGCAGGCCTGAGACTGCTAT
CCCTAGAAAGGTCTGCTTGCAAAGTTGGCCCTTGGCTGGCATCTGGGGGAACTTGGTTCTTGGATGGATTCCTGCCATTCACTGATAAGA
ATGGCTCACCTTGCCTAAAGTATATGAAGAGTGTGCTTTATGTCGAGCTCCTGCTTGCTTGCCTCTTTCTTTGTCTTTCTTTCTTTTCCT
TCCTCCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTCTCTCTCTCTCTTTCTTTCTTTCTTC

>55680_55680_2_MTHFD1L-IFT81_MTHFD1L_chr6_151198962_ENST00000367307_IFT81_chr12_110600724_ENST00000361948_length(amino acids)=306AA_BP=222
MSGTAYQTKVPKAVTSRPAARRPPPSARHGRRVQCPLGAPGTRRKRQVLPAAAAAAAACSPGTRPAALGSRSSVSPENQPSRAMGTRLPL
VLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQEKNPAFK
PVLAIIQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGD

--------------------------------------------------------------
>55680_55680_3_MTHFD1L-IFT81_MTHFD1L_chr6_151198962_ENST00000367307_IFT81_chr12_110600724_ENST00000552912_length(transcript)=2224nt_BP=685nt
CCACTCCGCACCCCACCCTCTGTCTGGTACAGCTTACCAAACCAAAGTGCCCAAAGCCGTGACATCCCGGCCGGCGGCTCGCAGGCCCCC
GCCCTCCGCACGTCACGGCCGCCGGGTGCAGTGCCCCCTAGGGGCCCCTGGGACGAGGAGGAAGCGCCAGGTCCTTCCCGCCGCCGCCGC
CGCCGCCGCCGCCTGCTCCCCTGGCACGCGCCCCGCCGCCCTCGGCAGCCGCAGCTCCGTGTCCCCTGAGAACCAGCCGTCCCGCGCCAT
GGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTGTCGCGC
TAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAGCAGCTG
CAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATTGCAAGA
AAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGCTGAGGA
GGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGGCATCTATCATTTCCCGTAAAAAAGAAGCCAAAGC
TGAGGAACTTCAGGAGGCCAAGGAGAAGTTAGCCAGCCTAGAGAGAGAAGCATCAGTAAAGAGAAATCAGACCCGTGAATTTGATGGTAC
TGAAGTTTTAAAGGGAGATGAGTTCAAACGATATGTCAATAAACTTCGAAGCAAGAGTACAGTTTTCAAAAAGAAGCATCAGATAATAGC
TGAACTTAAAGCTGAATTCGGTCTTTTGCAGAGGACTGAAGAACTTCTTAAGCAACGTCATGAAAATATTCAACAACAACTGCAAACTAT
GGAGGAGAAAAAGGGTATATCTGGATATAGTTACACCCAAGAAGAGCTAGAAAGAGTATCTGCACTGAAGAGTGAAGTTGATGAAATGAA
AGGACGAACATTGGATGATATGTCTGAAATGGTGAAAAAACTGTATTCATTGGTATCTGAAAAGAAGTCAGCTCTTGCCTCAGTTATAAA
AGAGCTACGACAGTTGCGTCAAAAATATCAAGAACTGACCCAGGAGTGTGATGAAAAGAAATCCCAGTATGATAGCTGTGCAGCAGGCCT
CGAAAGCAATCGGTCCAAATTAGAACAGGAAGTTAGAAGACTCCGTGAAGAATGTCTTCAAGAAGAAAGTAGATACCATTATACAAATTG
TATGATTAAGAACCTAGAAGTTCAACTTCGTCGTGCTACTGATGAGATGAAGGCATATATCTCTTCTGATCAACAAGAAAAAAGAAAGGC
AATTAGGGAACAGTATACCAAAAATACTGCTGAACAAGAAAACCTTGGAAAGAAACTTCGGGAAAAACAAAAAGTTATACGAGAAAGTCA
TGGTCCAAATATGAAACAAGCAAAAATGTGGCGTGATTTGGAACAATTAATGGAATGTAAGAAACAGTGCTTTCTGAAACAACAAAGCCA
AACTTCCATTGGTCAGGTAATTCAGGAGGGTGGGGAGGACCGGCTAATACTGTGAATTCTTGTGTCATCGTTTGGGGTTTTACTTGATAC
CACTAGCTATAAGCCTAATCTCATAATGTATTTCTTTTTTGAAACTGATTTGTATAGCATTTTGTTTTCAGAAGAGCCATTCTTTATTAA
GTTTTCATAGAAAATAATGTTAAGGTAGATTTAGTTTGAATGTTTTTTCATATGAAAAAGAGGCTTTTATTCTTTTCCATAGTTTAGACA
TCACTGGCGTCTTCTGAGTTTTATGAGACAGGAAACTAAGTTTACTATCTGTAAATGTAAACATATGTCCATTAAGAAACATGTAGTTTT
TTTTTAGAATGTAATAACCCAGTGGCTTACTGTTTTTCTTAATCTCTTTTAAAAAAACTTTAGAAGAATCTTTTAGGAACTAATATCTCT
TGTTCTGAAGAAACATTTATCTGACGTTCAGCAGTTCCTACAGTTTTACTTCAGTTTATTTTTCTTCTGTAAAATGCAAGAAAATTTAAT

>55680_55680_3_MTHFD1L-IFT81_MTHFD1L_chr6_151198962_ENST00000367307_IFT81_chr12_110600724_ENST00000552912_length(amino acids)=551AA_BP=222
MSGTAYQTKVPKAVTSRPAARRPPPSARHGRRVQCPLGAPGTRRKRQVLPAAAAAAAACSPGTRPAALGSRSSVSPENQPSRAMGTRLPL
VLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQEKNPAFK
PVLAIIQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGD
EFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDD
MSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLE
VQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQV

--------------------------------------------------------------
>55680_55680_4_MTHFD1L-IFT81_MTHFD1L_chr6_151198962_ENST00000367321_IFT81_chr12_110600724_ENST00000242591_length(transcript)=2252nt_BP=691nt
TGAGTCCCACTCCGCACCCCACCCTCTGTCTGGTACAGCTTACCAAACCAAAGTGCCCAAAGCCGTGACATCCCGGCCGGCGGCTCGCAG
GCCCCCGCCCTCCGCACGTCACGGCCGCCGGGTGCAGTGCCCCCTAGGGGCCCCTGGGACGAGGAGGAAGCGCCAGGTCCTTCCCGCCGC
CGCCGCCGCCGCCGCCGCCTGCTCCCCTGGCACGCGCCCCGCCGCCCTCGGCAGCCGCAGCTCCGTGTCCCCTGAGAACCAGCCGTCCCG
CGCCATGGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTG
TCGCGCTAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAG
CAGCTGCAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATT
GCAAGAAAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGC
TGAGGAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGGCATCTATCATTTCCCGTAAAAAAGAAGC
CAAAGCTGAGGAACTTCAGGAGGCCAAGGAGAAGTTAGCCAGCCTAGAGAGAGAAGCATCAGTAAAGAGAAATCAGACCCGTGAATTTGA
TGGTACTGAAGTTTTAAAGGGAGATGAGTTCAAACGATATGTCAATAAACTTCGAAGCAAGAGTACAGTTTTCAAAAAGAAGCATCAGAT
AATAGCTGAACTTAAAGCTGAATTCGGTCTTTTGCAGAGGACTGAAGAACTTCTTAAGCAACGTCATGAAAATATTCAACAACAACTGCA
AACTATGGAGGAGAAAAAGGGTATATCTGGATATAGTTACACCCAAGAAGAGCTAGAAAGAGTATCTGCACTGAAGAGTGAAGTTGATGA
AATGAAAGGACGAACATTGGATGATATGTCTGAAATGGTGAAAAAACTGTATTCATTGGTATCTGAAAAGAAGTCAGCTCTTGCCTCAGT
TATAAAAGAGCTACGACAGTTGCGTCAAAAATATCAAGAACTGACCCAGGAGTGTGATGAAAAGAAATCCCAGTATGATAGCTGTGCAGC
AGGCCTCGAAAGCAATCGGTCCAAATTAGAACAGGAAGTTAGAAGACTCCGTGAAGAATGTCTTCAAGAAGAAAGTAGATACCATTATAC
AAATTGTATGATTAAGAACCTAGAAGTTCAACTTCGTCGTGCTACTGATGAGATGAAGGCATATATCTCTTCTGATCAACAAGAAAAAAG
AAAGGCAATTAGGGAACAGTATACCAAAAATACTGCTGAACAAGAAAACCTTGGAAAGAAACTTCGGGAAAAACAAAAAGTTATACGAGA
AAGTCATGGTCCAAATATGAAACAAGCAAAAATGTGGCGTGATTTGGAACAATTAATGGAATGTAAGAAACAGTGCTTTCTGAAACAACA
AAGCCAAACTTCCATTGGTCAGGTAATTCAGGAGGGTGGGGAGGACCGGCTAATACTGTGAATTCTTGTGTCATCGTTTGGGGTTTTACT
TGATACCACTAGCTATAAGCCTAATCTCATAATGTATTTCTTTTTTGAAACTGATTTGTATAGCATTTTGTTTTCAGAAGAGCCATTCTT
TATTAAGTTTTCATAGAAAATAATGTTAAGGTAGATTTAGTTTGAATGTTTTTTCATATGAAAAAGAGGCTTTTATTCTTTTCCATAGTT
TAGACATCACTGGCGTCTTCTGAGTTTTATGAGACAGGAAACTAAGTTTACTATCTGTAAATGTAAACATATGTCCATTAAGAAACATGT
AGTTTTTTTTTAGAATGTAATAACCCAGTGGCTTACTGTTTTTCTTAATCTCTTTTAAAAAAACTTTAGAAGAATCTTTTAGGAACTAAT
ATCTCTTGTTCTGAAGAAACATTTATCTGACGTTCAGCAGTTCCTACAGTTTTACTTCAGTTTATTTTTCTTCTGTAAAATGCAAGAAAA
TTTAATATTTTGACTAACATGTCTTTTCTGTTTGTATCATTTAAAGGCAAATAAACTTGGTACGTATTTCATATCTATTTAAAAAATGTA

>55680_55680_4_MTHFD1L-IFT81_MTHFD1L_chr6_151198962_ENST00000367321_IFT81_chr12_110600724_ENST00000242591_length(amino acids)=551AA_BP=222
MSGTAYQTKVPKAVTSRPAARRPPPSARHGRRVQCPLGAPGTRRKRQVLPAAAAAAAACSPGTRPAALGSRSSVSPENQPSRAMGTRLPL
VLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQEKNPAFK
PVLAIIQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGD
EFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDD
MSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLE
VQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQV

--------------------------------------------------------------
>55680_55680_5_MTHFD1L-IFT81_MTHFD1L_chr6_151198962_ENST00000367321_IFT81_chr12_110600724_ENST00000361948_length(transcript)=2150nt_BP=691nt
TGAGTCCCACTCCGCACCCCACCCTCTGTCTGGTACAGCTTACCAAACCAAAGTGCCCAAAGCCGTGACATCCCGGCCGGCGGCTCGCAG
GCCCCCGCCCTCCGCACGTCACGGCCGCCGGGTGCAGTGCCCCCTAGGGGCCCCTGGGACGAGGAGGAAGCGCCAGGTCCTTCCCGCCGC
CGCCGCCGCCGCCGCCGCCTGCTCCCCTGGCACGCGCCCCGCCGCCCTCGGCAGCCGCAGCTCCGTGTCCCCTGAGAACCAGCCGTCCCG
CGCCATGGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTG
TCGCGCTAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAG
CAGCTGCAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATT
GCAAGAAAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGC
TGAGGAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGGCATCTATCATTTCCCGTAAAAAAGAAGC
CAAAGCTGAGGAACTTCAGGAGGCCAAGGAGAAGTTAGCCAGCCTAGAGAGAGAAGCATCAGTAAAGAGAAATCAGACCCGTGAATTTGA
TGGTACTGAAGTTTTAAAGGGAGATGAGAGACAGGATCTCACTCTGTCACCCAGGCTGGAGTGCGGTGGTGTGATCATGGCTTACTGCAG
CCTGAAACTCCTAGGCTCAAGTGATCCTCCTACCTCAGCCTCCTGAGAAGCTCGGACTACAGGCACGAGCCACCATGCCCAGCTAATTTT
CTTTTTTTGTTTTGTTTTGTAGAGATGTGGTCTCACTATGTTTCCCAGGCTGGTCTTAAACTCCCGGCCTCAAGCAGTCCTCCCACTTCG
GCCTCCTGAAGTGTTAGGATTACAGGCGTGAGCCTGCGCCTGGCTGTAATTACTATACCCAGTTTTTACAGATAAAGGATCTGAGACATG
CAGAGGTTTTAAGCTGACTTGCCTGACACCCCATTGCTAGTAAGTAGTAGAACCAGGAGTTGGATTTAGCAGTCTGGCTGTAGAGTCATC
AATAGTTTGCACATGACAGAAAGCTGGAAGAAATAGTCAACCTGAAACACATGATGGAATTATAATTCAGAATCATCTTGGTAGATAGGG
GCACTGTGCTTAAACAAAATGCCATTAATGGGATTATAATAAATATAATGTGGTAGAATTCAAGTTTTGTTTGCCAATTCAACACATCAT
CTGTTACTAACGCAGCTTTAAAAAATGCATAAACGATTATACTACATTAATTTTTTTAAAAAGTATCCTGTTTATGGTCTGATTATGCCT
GGAGTATTATTTTATATTTTTGACTTCATGTTTTAAGAGACAATCATGCCAGAGTCCCACATGAGGGTGACTAAAATGGACAAAAAGTCT
GGAAACTTTCATATCAATAATTGATTATGTATTAACTGAAACAAAAGACTAGAGAAAGACACAGTGGGAATTGATTATGTATTAACTGAG
GAATAAAAGACTGAAGAAAGACATAATAAATAGTTAAAGGATTATGGAAAAGATGGTGTTCAGAAAAAAATTAACATGCAGGCCTGAGAC
TGCTATCCCTAGAAAGGTCTGCTTGCAAAGTTGGCCCTTGGCTGGCATCTGGGGGAACTTGGTTCTTGGATGGATTCCTGCCATTCACTG
ATAAGAATGGCTCACCTTGCCTAAAGTATATGAAGAGTGTGCTTTATGTCGAGCTCCTGCTTGCTTGCCTCTTTCTTTGTCTTTCTTTCT
TTTCCTTCCTCCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTCTCTCTCTCTCTTTCTTTCT

>55680_55680_5_MTHFD1L-IFT81_MTHFD1L_chr6_151198962_ENST00000367321_IFT81_chr12_110600724_ENST00000361948_length(amino acids)=306AA_BP=222
MSGTAYQTKVPKAVTSRPAARRPPPSARHGRRVQCPLGAPGTRRKRQVLPAAAAAAAACSPGTRPAALGSRSSVSPENQPSRAMGTRLPL
VLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQEKNPAFK
PVLAIIQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGD

--------------------------------------------------------------
>55680_55680_6_MTHFD1L-IFT81_MTHFD1L_chr6_151198962_ENST00000367321_IFT81_chr12_110600724_ENST00000552912_length(transcript)=2230nt_BP=691nt
TGAGTCCCACTCCGCACCCCACCCTCTGTCTGGTACAGCTTACCAAACCAAAGTGCCCAAAGCCGTGACATCCCGGCCGGCGGCTCGCAG
GCCCCCGCCCTCCGCACGTCACGGCCGCCGGGTGCAGTGCCCCCTAGGGGCCCCTGGGACGAGGAGGAAGCGCCAGGTCCTTCCCGCCGC
CGCCGCCGCCGCCGCCGCCTGCTCCCCTGGCACGCGCCCCGCCGCCCTCGGCAGCCGCAGCTCCGTGTCCCCTGAGAACCAGCCGTCCCG
CGCCATGGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTG
TCGCGCTAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAG
CAGCTGCAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATT
GCAAGAAAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGC
TGAGGAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGGCATCTATCATTTCCCGTAAAAAAGAAGC
CAAAGCTGAGGAACTTCAGGAGGCCAAGGAGAAGTTAGCCAGCCTAGAGAGAGAAGCATCAGTAAAGAGAAATCAGACCCGTGAATTTGA
TGGTACTGAAGTTTTAAAGGGAGATGAGTTCAAACGATATGTCAATAAACTTCGAAGCAAGAGTACAGTTTTCAAAAAGAAGCATCAGAT
AATAGCTGAACTTAAAGCTGAATTCGGTCTTTTGCAGAGGACTGAAGAACTTCTTAAGCAACGTCATGAAAATATTCAACAACAACTGCA
AACTATGGAGGAGAAAAAGGGTATATCTGGATATAGTTACACCCAAGAAGAGCTAGAAAGAGTATCTGCACTGAAGAGTGAAGTTGATGA
AATGAAAGGACGAACATTGGATGATATGTCTGAAATGGTGAAAAAACTGTATTCATTGGTATCTGAAAAGAAGTCAGCTCTTGCCTCAGT
TATAAAAGAGCTACGACAGTTGCGTCAAAAATATCAAGAACTGACCCAGGAGTGTGATGAAAAGAAATCCCAGTATGATAGCTGTGCAGC
AGGCCTCGAAAGCAATCGGTCCAAATTAGAACAGGAAGTTAGAAGACTCCGTGAAGAATGTCTTCAAGAAGAAAGTAGATACCATTATAC
AAATTGTATGATTAAGAACCTAGAAGTTCAACTTCGTCGTGCTACTGATGAGATGAAGGCATATATCTCTTCTGATCAACAAGAAAAAAG
AAAGGCAATTAGGGAACAGTATACCAAAAATACTGCTGAACAAGAAAACCTTGGAAAGAAACTTCGGGAAAAACAAAAAGTTATACGAGA
AAGTCATGGTCCAAATATGAAACAAGCAAAAATGTGGCGTGATTTGGAACAATTAATGGAATGTAAGAAACAGTGCTTTCTGAAACAACA
AAGCCAAACTTCCATTGGTCAGGTAATTCAGGAGGGTGGGGAGGACCGGCTAATACTGTGAATTCTTGTGTCATCGTTTGGGGTTTTACT
TGATACCACTAGCTATAAGCCTAATCTCATAATGTATTTCTTTTTTGAAACTGATTTGTATAGCATTTTGTTTTCAGAAGAGCCATTCTT
TATTAAGTTTTCATAGAAAATAATGTTAAGGTAGATTTAGTTTGAATGTTTTTTCATATGAAAAAGAGGCTTTTATTCTTTTCCATAGTT
TAGACATCACTGGCGTCTTCTGAGTTTTATGAGACAGGAAACTAAGTTTACTATCTGTAAATGTAAACATATGTCCATTAAGAAACATGT
AGTTTTTTTTTAGAATGTAATAACCCAGTGGCTTACTGTTTTTCTTAATCTCTTTTAAAAAAACTTTAGAAGAATCTTTTAGGAACTAAT
ATCTCTTGTTCTGAAGAAACATTTATCTGACGTTCAGCAGTTCCTACAGTTTTACTTCAGTTTATTTTTCTTCTGTAAAATGCAAGAAAA

>55680_55680_6_MTHFD1L-IFT81_MTHFD1L_chr6_151198962_ENST00000367321_IFT81_chr12_110600724_ENST00000552912_length(amino acids)=551AA_BP=222
MSGTAYQTKVPKAVTSRPAARRPPPSARHGRRVQCPLGAPGTRRKRQVLPAAAAAAAACSPGTRPAALGSRSSVSPENQPSRAMGTRLPL
VLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQEKNPAFK
PVLAIIQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGD
EFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDD
MSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLE
VQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MTHFD1L-IFT81


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MTHFD1L-IFT81


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MTHFD1L-IFT81


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource