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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MTHFD1L-RGS17 (FusionGDB2 ID:55684) |
Fusion Gene Summary for MTHFD1L-RGS17 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MTHFD1L-RGS17 | Fusion gene ID: 55684 | Hgene | Tgene | Gene symbol | MTHFD1L | RGS17 | Gene ID | 25902 | 26575 |
| Gene name | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like | regulator of G protein signaling 17 | |
| Synonyms | FTHFSDC1|MTC1THFS|dJ292B18.2 | RGS-17|RGSZ2|hRGS17 | |
| Cytomap | 6q25.1 | 6q25.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | monofunctional C1-tetrahydrofolate synthase, mitochondrial10-formyl-THF synthetaseformyltetrahydrofolate synthetase domain containing 1 | regulator of G-protein signaling 17 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q6UB35 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000367307, ENST00000367321, ENST00000478643, | ENST00000206262, ENST00000367225, | |
| Fusion gene scores | * DoF score | 11 X 14 X 5=770 | 5 X 6 X 3=90 |
| # samples | 13 | 6 | |
| ** MAII score | log2(13/770*10)=-2.56634682255381 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MTHFD1L [Title/Abstract] AND RGS17 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MTHFD1L(151209117)-RGS17(153365178), # samples:4 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MTHFD1L | GO:0006760 | folic acid-containing compound metabolic process | 12937168 |
| Hgene | MTHFD1L | GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | 12937168 |
| Hgene | MTHFD1L | GO:0015942 | formate metabolic process | 16171773 |
| Fusion gene breakpoints across MTHFD1L (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across RGS17 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-A2-A0CY-01A | MTHFD1L | chr6 | 151209117 | - | RGS17 | chr6 | 153365178 | - |
| ChimerDB4 | BRCA | TCGA-A2-A0CY-01A | MTHFD1L | chr6 | 151209117 | + | RGS17 | chr6 | 153365178 | - |
| ChimerDB4 | BRCA | TCGA-A2-A0CY | MTHFD1L | chr6 | 151209117 | + | RGS17 | chr6 | 153365178 | - |
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Fusion Gene ORF analysis for MTHFD1L-RGS17 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000367307 | ENST00000206262 | MTHFD1L | chr6 | 151209117 | + | RGS17 | chr6 | 153365178 | - |
| 5CDS-5UTR | ENST00000367321 | ENST00000206262 | MTHFD1L | chr6 | 151209117 | + | RGS17 | chr6 | 153365178 | - |
| In-frame | ENST00000367307 | ENST00000367225 | MTHFD1L | chr6 | 151209117 | + | RGS17 | chr6 | 153365178 | - |
| In-frame | ENST00000367321 | ENST00000367225 | MTHFD1L | chr6 | 151209117 | + | RGS17 | chr6 | 153365178 | - |
| intron-3CDS | ENST00000478643 | ENST00000367225 | MTHFD1L | chr6 | 151209117 | + | RGS17 | chr6 | 153365178 | - |
| intron-5UTR | ENST00000478643 | ENST00000206262 | MTHFD1L | chr6 | 151209117 | + | RGS17 | chr6 | 153365178 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000367321 | MTHFD1L | chr6 | 151209117 | + | ENST00000367225 | RGS17 | chr6 | 153365178 | - | 8827 | 1054 | 25 | 1068 | 347 |
| ENST00000367307 | MTHFD1L | chr6 | 151209117 | + | ENST00000367225 | RGS17 | chr6 | 153365178 | - | 8821 | 1048 | 19 | 1062 | 347 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000367321 | ENST00000367225 | MTHFD1L | chr6 | 151209117 | + | RGS17 | chr6 | 153365178 | - | 0.000697236 | 0.99930274 |
| ENST00000367307 | ENST00000367225 | MTHFD1L | chr6 | 151209117 | + | RGS17 | chr6 | 153365178 | - | 0.000696926 | 0.9993031 |
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Fusion Genomic Features for MTHFD1L-RGS17 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MTHFD1L-RGS17 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:151209117/chr6:153365178) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MTHFD1L | . |
| FUNCTION: May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. {ECO:0000250, ECO:0000269|PubMed:16171773}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MTHFD1L | chr6:151209117 | chr6:153365178 | ENST00000367307 | + | 7 | 8 | 34_42 | 260 | 276.0 | Compositional bias | Note=Poly-Gly |
| Hgene | MTHFD1L | chr6:151209117 | chr6:153365178 | ENST00000367321 | + | 7 | 28 | 34_42 | 260 | 932.6666666666666 | Compositional bias | Note=Poly-Gly |
| Tgene | RGS17 | chr6:151209117 | chr6:153365178 | ENST00000206262 | 0 | 5 | 28_40 | 0 | 211.0 | Compositional bias | Note=Poly-Cys | |
| Tgene | RGS17 | chr6:151209117 | chr6:153365178 | ENST00000206262 | 0 | 5 | 84_200 | 0 | 211.0 | Domain | RGS | |
| Tgene | RGS17 | chr6:151209117 | chr6:153365178 | ENST00000367225 | -1 | 4 | 84_200 | 39 | 211.0 | Domain | RGS |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MTHFD1L | chr6:151209117 | chr6:153365178 | ENST00000367307 | + | 7 | 8 | 423_430 | 260 | 276.0 | Nucleotide binding | ATP |
| Hgene | MTHFD1L | chr6:151209117 | chr6:153365178 | ENST00000367321 | + | 7 | 28 | 423_430 | 260 | 932.6666666666666 | Nucleotide binding | ATP |
| Hgene | MTHFD1L | chr6:151209117 | chr6:153365178 | ENST00000367307 | + | 7 | 8 | 31_348 | 260 | 276.0 | Region | Note=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase |
| Hgene | MTHFD1L | chr6:151209117 | chr6:153365178 | ENST00000367307 | + | 7 | 8 | 349_978 | 260 | 276.0 | Region | Note=Formyltetrahydrofolate synthetase |
| Hgene | MTHFD1L | chr6:151209117 | chr6:153365178 | ENST00000367321 | + | 7 | 28 | 31_348 | 260 | 932.6666666666666 | Region | Note=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase |
| Hgene | MTHFD1L | chr6:151209117 | chr6:153365178 | ENST00000367321 | + | 7 | 28 | 349_978 | 260 | 932.6666666666666 | Region | Note=Formyltetrahydrofolate synthetase |
| Tgene | RGS17 | chr6:151209117 | chr6:153365178 | ENST00000367225 | -1 | 4 | 28_40 | 39 | 211.0 | Compositional bias | Note=Poly-Cys |
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Fusion Gene Sequence for MTHFD1L-RGS17 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >55684_55684_1_MTHFD1L-RGS17_MTHFD1L_chr6_151209117_ENST00000367307_RGS17_chr6_153365178_ENST00000367225_length(transcript)=8821nt_BP=1048nt CCACTCCGCACCCCACCCTCTGTCTGGTACAGCTTACCAAACCAAAGTGCCCAAAGCCGTGACATCCCGGCCGGCGGCTCGCAGGCCCCC GCCCTCCGCACGTCACGGCCGCCGGGTGCAGTGCCCCCTAGGGGCCCCTGGGACGAGGAGGAAGCGCCAGGTCCTTCCCGCCGCCGCCGC CGCCGCCGCCGCCTGCTCCCCTGGCACGCGCCCCGCCGCCCTCGGCAGCCGCAGCTCCGTGTCCCCTGAGAACCAGCCGTCCCGCGCCAT GGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTGTCGCGC TAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAGCAGCTG CAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATTGCAAGA AAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGCTGAGGA GGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGATTATAGATGAAATCTTAAAGATCAATGAAGATAC CAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAACTTGTTTAGCAACAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGTGGATGG AGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGGGATGCCCATGAATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGAACTTCT TGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATTTTGGTAGTGGGGGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCTGTTCCA GAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAAACACGCCAGCTTCAAAGCAAGCCAACTGGGTCCTGAAGTAGCTGAAATGCGAA AAAGGCAGCAGTCCCAAAATGAAGGAACACCTGCCGTGTCTCAAGCTCCTGGAAACCAGAGGCCCAACAACACCTGTTGCTTTTGTTGGT GCTGTTGTTGCAGCTGCTCCTGCCTCACTGTGAGGAATGAAGAAAGAGGGGAAAATGCGGGAAGACCCACACACACTACAAAAATGGAGA GTATCCAGGTCCTAGAGGAATGCCAAAACCCCACTGCAGAGGAAGTCTTGTCCTGGTCTCAAAATTTTGACAAGATGATGAAGGCCCCAG CAGGAAGAAACCTTTTCAGAGAGTTCCTCCGAACAGAATACAGTGAAGAGAACCTACTTTTCTGGCTTGCTTGTGAAGACTTAAAGAAGG AGCAGAACAAAAAAGTAATTGAAGAAAAGGCTAGGATGATATATGAAGATTACATTTCTATACTATCACCAAAAGAGGTCAGTCTTGATT CTCGAGTTAGAGAGGTGATCAATAGAAATCTGTTGGATCCCAATCCTCACATGTATGAAGATGCCCAACTTCAGATATATACTTTAATGC ACAGAGATTCTTTTCCAAGGTTTTTGAACTCTCAAATTTATAAGTCATTTGTTGAAAGTACTGCTGGCTCTTCTTCTGAATCTTAATGTT CATTTAAAAACAATCATTTTGGAGGGCTGAGATGGGAAATAAAAGTAGTTAAATAACATCAGAAACTGAGTTCCTGGAGAACTACAGTTT AGCATTCCTCAGGCTACTGTGAAAACACAACCGTTATGGTCTTTGTCTCCATTTTTATCAAGGTTTTCCATGGTTAAGTTTGGAGAAAAT ACCACACAAAACAATGAATTGCCAAATTGTTTGTTTTATTCAAGACTCATTCTACTTGCAAGCAAAGTGTATTTGTAGTCCTATGAACAG TCTCCTCGTGTATCTCCAGAGACTGCATGTGCAAAGTAAAATGCTTCATTTGCCACATAGTTGTTGTAATATTTAATCCAGTAGCATAAC TTATATCTGTATTTAAGGACTTTTGTGCAATATGGTCTTAAGAAATAATTGCCAAAAAAATCGGCCATGGTTTGCATTTTTTAACATAAT CTAAGACAGAAAAAAAGCAATTTTTACTATGTAACAATGGTATTCAACATTCTATATACTGTGTTTAGTACACTAATTTTGAAGCCAATA TTTCTGTACATGAAAAAGAGCTATTTATCTCTGTTTGTTGGAAAATCCTAATGGGGATTCCTCTGGTTGTTCACTGCCAAAACTGTGGCA TTTTCATTACAGGAGAGTTTACTATGCTAAAAGCAAAAAACAAAAAAAAAAAAAAAGGGAAGAAGGAAAAAAGCACAAAACAATTTGAAG ATATCCTATCTCAATGACAAATCAAAAGAGTGATATTGCTTTTAACTGTAATAGAAGAAAATGAATTTATGTATATATCAGATGTCCAAT ACTGTAATTAATTTATTAAAGACTGGCTCTCCAGTTTTAAAATGGTTGTGTAAAGTTATGTACTTCAGCAAGAAAAAAATAATAATAAGC TTGATAACTTAGTTTTGGAATATAAAGAAAAGGACTTAATAAAGGAATGCCTACATGTAGCACTGTAAAACATTTTGATGAATAGCATCT GTCCTGTGGCATATTTTCCTTGAAAGTGAAATCCAATGAAAAGCTAAGTTTTTACCAGGAAAAGTTTTATAAGGGTTATGAAGAAAATAA TCCTCTACTTCAGACCTTAACTGTTTTCACATAATATCTTAAGGATGACATTTTAAAGATGTTTAAACCAAACTATTAGTTTTCATCCAT CATTAAAAGGCAGTACAGTGCTCAAATCTTCCAGCTGCCATATTATTTTTTATAAGTACACTAAATCTTTACGACAAAACACTTGCCTGA CATTGTCATGTACTTCTGACCTTCAAGGAAACAATATTCTGTCATGCATAAAAGTGATAATTAAAATAATCAGTGTCATATTTATATCAA AGTGTTACATTTGAATATTAATATCCCCTGAAGACTATTTTTTTAATATTAAACTGAATGAATATAATACTGAGTAACCTAAAATGAAAG TTTTAAAAAGATTTATATCCACTGAGAACACTGGCCTTATATTAAGGATGATATTACAGTTACAGGTTTTCTTTGTCATTTTTTTAACTA CCTCTCATTTTTTAATTTATTAAACATATTTTTTAAAAAAACAAGTTTGGGGGTTTCTTTTTAAATTTATTTTACTTGAAAGGTTGGCAT CACAAGTTTCTTTTTCCATAAACTTAAAACATTTCAAAAATGGTTTTTTTAAGCAAGTATGATTTTCTAATTTATATAGAATTCAGGAGA CATGAATAAAAGGGCTATTATCTATTCCCTATGCAAATATTTTAACTGTTGCAGTGTTTGACAAAATGGGATTTTTTAAAAATTGCAGAG TAGAAAACAAAATATTCTGTTTACACTGGCGTTGCTGACTATCCTACCATATTCAGCACTTTTAAATACGTTATTTATGAAAATGCAGTT AAAATGCAAGATAGAAAATATTTATAATAATCATTTCTTTTAACAAATGCCTGTGTTTTCTGAAAGTGTTAGTGTGTTAAGACATATTTT ATTCATGTCATTTAAATACTATTTGAATAAGTTTTCAGTAATATGTTGAAAAAAAGATAGCTATGAAGATGTTTACAAAAAGTCATATTT TTTCCTAAAGAGTAAAGAAAAACCTAAAAGAATCATCACTTCTATTGTGAAGTTCTATTGTTCCTAAATTATTTAATTTTTTTCTTGCTT AGAATTGAGTTTATTATGCTACTATGATATATACACATGTATGGTGTAGTATCATATTTGTTTCTGTGTGTGAGGCTCAACAAATTGGTG CACATGACTAGAAAATATGTAATATACTGTGATACACTGCATGCATCCATCTTTTTAAATGTAGACTTTATATTCTCGTTGTTACTATAT ATGATGGTGACCTGCTAGTCATAAGTTATCTTTATAAGATACTTTGGACTATTAGATGAATTGTCTGTTTGACAATATCTTTAATATTTT ACCAAATGTAAAAGATAAGGGCCGTTATAAAGAGTCCTAATCTCTAACCTGGGCATTTGTAGAACACAGATTTTAAAGTTGGTATATCCT TTTGAAACCTGATGAGGAAGTTGAGTTAAAAAAGATTCGAGAGCAGATTTACACATCAGATGTTGATAACCATGCTATGTGAGCATTTCT GTGCTAAACTCGTATTTTTGGGTGAGGGGAGGGTTTCTCATTTAAGAGTATGTCTGTATATTTGCAACTCTACTAATTTTCTAAGTATGA TATAATTCCTTCTGTTTAAGTTACAGAGCTATTATAAATAAACAAAAGAGCCTTCAACTGGTGTCTATGCTACCATTCCAAGAGCACAAT ATTTGTTTTCTTAGAATTTGAGTTTTCCTAGTGAGTAAATTCCTCCCTGGGGAAAAATTAGCACTTTAAAATGGACACTTTGTGTTTTCA ATTGCCAAGGTATCTTTGTATACTATTAGAATTTGCTGATGCACACAGAAAGAGATTAATGCACTTTCTATAGTGCCTAACTTTAGATGT ATCTATAAAAGAAAGTAGAGGATACAGATTATGTATATATAAATAAATTGGAGAGCCAGATTTCTTCAGAGATTGATCTTGTACATTAAT CACACCAGTAATGGATGGATGGCACTTCTTTACTCGGGCTGTTATGATGTTATCCAAAGGTAGTAGAGATGCTCTGACAGTGTTGGAGTG TGCACATGAACAACAAGAGCAAAACACAACTTTGATACTAAAGTTACGAAATGCAGAAGTCAAGACCATAATGTGATGTTTTTTTTTTTT GAAATCTTAAAATATGTACATAGAATGACCAGTTCTGATATGCCGTCTTAGTGCATGGATGTTTATTAGTATCCTTTAATGCTGCCTAGG TTCTGACTTACAGAATGAAATACGTGTTGTTTATCTACCTGATAGTTCAGTTTTGCCAAAGGACTATAGGGATAAGTGAATAATATTTAT TTATTAGGAGCAAAAATACATTTTCATCCCATTAAGCTAATTTAAAATAATGCCTGATTTTTACTTTTGAGTTTATCCATTTTTCTATAC CTTTAACTTATTTATACTTTAAAAAATCATATTGTAATTGTGACAAATTATATCTCAAAAAATACCAATTATTAGATGCTTTGGTGTTGA AATGTAAAAGAGAAGGAATTTAAAATACAATCAAAAAAGTCAAAAATAAAACGTATTTGAAAACCACCTAAAATTTCTTGGCCAGGCACA GTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAAGCCAAAGAGGGCGGATCACTTGAGCTCAGGAGTTTGAGACCAGACTGGCCAACATG GTGAAACCCCGACTCTAGTAAAAATACAAAATTAGCCGGGCATGGTGGTGGGTGCCTTTAATCCCGGCTACTTGAGAGGCTGAGGCAGGA GAATCGCTTGAACCCAGGAGGCAGAGGTCGCAGTGAGCTGATATCATGCCACTGCACTCCAGCCTTGGCAACAGAGTGACTCCATCTCAA AATAATAATAATAATTATAATAATAATATTTTTAAGTCTTAGACAGAAAATGCCTATAGATAGAAGCCTATCAAACATGTATTTTGAATA CTTTGATCTTGACACATTGCCTAATTATTTTGAAAGATGGTAAAGATATTTCCAAAAAATATTTTCGCCTATCTGTTTACATTGACAGTT TACAACCATAATTTTCTAAGTATATTTTTCAAACATGTATTTTTGTGTTTTCCATCTTCAAATTTCTGACCAATGGGTTTGTTCTCCTGC AAAAACAATATCCAATCTGCAAAAATTTTTAATTCTTCACTTGCTACAACTGCAAATATTTATCAATAAAACTGATAACCCAAAACTTGC TTCAGATTTTCCCTGCAGTGCTTAAAATATCCTTGCAACACAAGATGGTGCACAATGACAAGTATTATTTCTGAATACCCAGATTTGATT TATTTATAGGTATTTTTGAAATTATTACTCTTACAGGTGTAGTCCTCTCCAGCCCCAAGTAACATCTTTTCAGATGAATTCAAGAGGCTG TTCAAGACTTTGACTCTACTGAAAACACTACAAAAGGCAAAATGTTGCCCTAGGTGATAGAAGGTCCCAGTTTGGGAACTGATTTTCTTC CTATGACAAAAGCTATAAGATGAGTAAGGTTACTAATGGAAATGTATGTCCACAGATTCACTTAGGGAGCATAGTGTAAAAACATCAGGA ACTTAAAATTACAAATTTGATTTCAAGTTATATTTCTGTCTCATGTGACTTTGGGCAAATCATTTATCTTCTCTGAGTTCATTTCCTCAT CTGCAAATGACAAATAAAATACGTAATTATCAGGATAACTATGAGCATTAAATAAAACAAACGTGGAAAGAATAAAGTGTGGCATACATT ATTATTTTATCAAAGTGCATCACGTCAATAATTGTTATTGTATACTTGTATTAAATGTCACTTTAATGCACTTTCCCCTATTTTTTTCCA AAACATACGTTAAACATCTGATTTAGCTACTCATCAAAACATACAATCATGTTTTAAGATGGAACACTATATCAGTGTTACTGCTTTTCT CAATAATGTGATCCCAAATCAGTACTTTCAGTTCACCATCACCTCAAATCTATAGAAATGTTTCTTTCAATGACATAGATAGATAGATGA TTGATAGATAGATGATAGATAGATGATAAATGGATATACAATTATAGGTTAAAATTAAAGTTTAAATAAGATCAATCATTTGAAAGTTTT ATTTCCAAAGGAAATAAAACAACATTCCCAAGGACAGAAATAATATCAAATTACTTGCTAAATATATAAATGAGTTATAGGGCTAAGACT AAGTTATAAGAGATTGACAATTAGAAAACACTCTTTTTAATATTAAGGTGGTATGATTTTCTTTAACAATTTTACAATGAAAATAAAAAC TTAATAAAAGGTGGTAATGGGCCAGGCACGGTGGCTCACGCATACAATCCCAGCACTTTGGGAGACTAAGGCGTGAGGATCACTTGAGCC CAGGAGTTCCAGACATGTCTATGCAACAAAGTGAGACCCTGACTCTAAGAAAAAAATAAAATGTATAAAATTTAAAATAGTAATGTGTCC ATTAAACCTTTTATTTTAGAGTAGTTTTAGATTTACAGAAAAACTCCAAATAGAGAGGTCCCATATACATCTATGGGCATTAATGAGCCA ATATTGATCATTACATTCATACTTCATTCAGATTTCCTTAGTTTATAACCTAATGTCCTTTTTCTGTCCCAGGATCCCATTCAGGATACC ACATTACATTTAGTTGTCATGTTTCCTTAGGCTTCCCTTGGCTGTGACAGTTTCTGCAACTTTCCTTGTTTTTGATGACAGTTTTGAGAA ATAAACTGGTATTTTGTAGAATGTCCTTCTATGGGGATTCGTCTGATGTTTTTCTCGTGACTAGACACAGGTTTTTGGTTTTTGAAAGAA CACAACGGTAAAGTGCCATGCTCATCACATGGTATCAAAGGTATATGCCATCACCGGGACTCGTCTTAGCTGTGACAGTTTCTCAAACTT TAGGCTACTCTTAGCTGTTGATGTTAACCTTGATCACTTAGCTGAGGTAGCATCTATTATATTTCTCCACTGTAAAGTAATGCGTTTTTA AAGAGATTATATTGAAGGTAAATTTTCTGGACATTTACACTGAGCTAAACAAATTCTAAACACTAATATTAGGTTCCACTAAGTGATTAC TAATAAATGCTATAAAGAAAATACAGTGAAGTGGAAAAATAAAACTCCAGAAGTCTTAGCCTGAATATTCACCTAATAGAGGTGAAAGTG AATTTTTCCCTTGAACTGTCTGCGCAATTTACAATAATCCTCCACATACTTTGGATATTAAAGATCTTATCTTACTAATTGTCATAAGAG GTAATTTAAATTTAAACTAACCATTTTGCTTATTGCATTTTTATATTGCCCTCCACTAATCAATGAACACTGAATATTGAAATAATGTAA AAGACCTATTTCCCGCTAGCTTTAACCGATTTGTCATAAACACCTTTCTTGTATATGATTTTTAAATGTTTGCTAAATATTAAAAAGAAT TCAATGTGTTTGGTTTTGTAAAATTACATATCGAATGTGTATAATTTTTTACTACCATGTTCATCACACTTAATCTATATCCATATATTG TACTCCACCAATATTTATCAGTGGACAATAAAGAAGTTTTGAATGCATGAATGCAACTTAAGAGGCACCACACTTGGTTATTTTGCAATG CCAGAATAACGGTGGGTATTCACAAATTGAATAGATAATCCAGATTATGTTTCCTCCAATTTAAGTTTTTCTGGGTTTTTTTTTCCCCCT TCCTAGAATCAATTTTATCATTTTACCTATGTACAATAATATACTTCTGGAAAATGCTAGAATTTTCACCATGTAACAGAATTTGAGCAT GACAGTAATGTAAAAATATTCAGAAGTCTCGAACTATAGGTTTGAGTTTTCAAAGTAAATCAAAATACAGCTGTTTTCATTTTACTAGAT TGTGGAAACCTATGGATGTTATTGTAAAATGCATATGCATTACACTGACTTTCTTAAAATGTTTTGAATTAATAAAGAATTCAACAATGT >55684_55684_1_MTHFD1L-RGS17_MTHFD1L_chr6_151209117_ENST00000367307_RGS17_chr6_153365178_ENST00000367225_length(amino acids)=347AA_BP= MSGTAYQTKVPKAVTSRPAARRPPPSARHGRRVQCPLGAPGTRRKRQVLPAAAAAAAACSPGTRPAALGSRSSVSPENQPSRAMGTRLPL VLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQEKNPAFK PVLAIIQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVDGVTDINL -------------------------------------------------------------- >55684_55684_2_MTHFD1L-RGS17_MTHFD1L_chr6_151209117_ENST00000367321_RGS17_chr6_153365178_ENST00000367225_length(transcript)=8827nt_BP=1054nt TGAGTCCCACTCCGCACCCCACCCTCTGTCTGGTACAGCTTACCAAACCAAAGTGCCCAAAGCCGTGACATCCCGGCCGGCGGCTCGCAG GCCCCCGCCCTCCGCACGTCACGGCCGCCGGGTGCAGTGCCCCCTAGGGGCCCCTGGGACGAGGAGGAAGCGCCAGGTCCTTCCCGCCGC CGCCGCCGCCGCCGCCGCCTGCTCCCCTGGCACGCGCCCCGCCGCCCTCGGCAGCCGCAGCTCCGTGTCCCCTGAGAACCAGCCGTCCCG CGCCATGGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTG TCGCGCTAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAG CAGCTGCAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATT GCAAGAAAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGC TGAGGAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGATTATAGATGAAATCTTAAAGATCAATGA AGATACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAACTTGTTTAGCAACAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGT GGATGGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGGGATGCCCATGAATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGA ACTTCTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATTTTGGTAGTGGGGGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCT GTTCCAGAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAAACACGCCAGCTTCAAAGCAAGCCAACTGGGTCCTGAAGTAGCTGAAA TGCGAAAAAGGCAGCAGTCCCAAAATGAAGGAACACCTGCCGTGTCTCAAGCTCCTGGAAACCAGAGGCCCAACAACACCTGTTGCTTTT GTTGGTGCTGTTGTTGCAGCTGCTCCTGCCTCACTGTGAGGAATGAAGAAAGAGGGGAAAATGCGGGAAGACCCACACACACTACAAAAA TGGAGAGTATCCAGGTCCTAGAGGAATGCCAAAACCCCACTGCAGAGGAAGTCTTGTCCTGGTCTCAAAATTTTGACAAGATGATGAAGG CCCCAGCAGGAAGAAACCTTTTCAGAGAGTTCCTCCGAACAGAATACAGTGAAGAGAACCTACTTTTCTGGCTTGCTTGTGAAGACTTAA AGAAGGAGCAGAACAAAAAAGTAATTGAAGAAAAGGCTAGGATGATATATGAAGATTACATTTCTATACTATCACCAAAAGAGGTCAGTC TTGATTCTCGAGTTAGAGAGGTGATCAATAGAAATCTGTTGGATCCCAATCCTCACATGTATGAAGATGCCCAACTTCAGATATATACTT TAATGCACAGAGATTCTTTTCCAAGGTTTTTGAACTCTCAAATTTATAAGTCATTTGTTGAAAGTACTGCTGGCTCTTCTTCTGAATCTT AATGTTCATTTAAAAACAATCATTTTGGAGGGCTGAGATGGGAAATAAAAGTAGTTAAATAACATCAGAAACTGAGTTCCTGGAGAACTA CAGTTTAGCATTCCTCAGGCTACTGTGAAAACACAACCGTTATGGTCTTTGTCTCCATTTTTATCAAGGTTTTCCATGGTTAAGTTTGGA GAAAATACCACACAAAACAATGAATTGCCAAATTGTTTGTTTTATTCAAGACTCATTCTACTTGCAAGCAAAGTGTATTTGTAGTCCTAT GAACAGTCTCCTCGTGTATCTCCAGAGACTGCATGTGCAAAGTAAAATGCTTCATTTGCCACATAGTTGTTGTAATATTTAATCCAGTAG CATAACTTATATCTGTATTTAAGGACTTTTGTGCAATATGGTCTTAAGAAATAATTGCCAAAAAAATCGGCCATGGTTTGCATTTTTTAA CATAATCTAAGACAGAAAAAAAGCAATTTTTACTATGTAACAATGGTATTCAACATTCTATATACTGTGTTTAGTACACTAATTTTGAAG CCAATATTTCTGTACATGAAAAAGAGCTATTTATCTCTGTTTGTTGGAAAATCCTAATGGGGATTCCTCTGGTTGTTCACTGCCAAAACT GTGGCATTTTCATTACAGGAGAGTTTACTATGCTAAAAGCAAAAAACAAAAAAAAAAAAAAAGGGAAGAAGGAAAAAAGCACAAAACAAT TTGAAGATATCCTATCTCAATGACAAATCAAAAGAGTGATATTGCTTTTAACTGTAATAGAAGAAAATGAATTTATGTATATATCAGATG TCCAATACTGTAATTAATTTATTAAAGACTGGCTCTCCAGTTTTAAAATGGTTGTGTAAAGTTATGTACTTCAGCAAGAAAAAAATAATA ATAAGCTTGATAACTTAGTTTTGGAATATAAAGAAAAGGACTTAATAAAGGAATGCCTACATGTAGCACTGTAAAACATTTTGATGAATA GCATCTGTCCTGTGGCATATTTTCCTTGAAAGTGAAATCCAATGAAAAGCTAAGTTTTTACCAGGAAAAGTTTTATAAGGGTTATGAAGA AAATAATCCTCTACTTCAGACCTTAACTGTTTTCACATAATATCTTAAGGATGACATTTTAAAGATGTTTAAACCAAACTATTAGTTTTC ATCCATCATTAAAAGGCAGTACAGTGCTCAAATCTTCCAGCTGCCATATTATTTTTTATAAGTACACTAAATCTTTACGACAAAACACTT GCCTGACATTGTCATGTACTTCTGACCTTCAAGGAAACAATATTCTGTCATGCATAAAAGTGATAATTAAAATAATCAGTGTCATATTTA TATCAAAGTGTTACATTTGAATATTAATATCCCCTGAAGACTATTTTTTTAATATTAAACTGAATGAATATAATACTGAGTAACCTAAAA TGAAAGTTTTAAAAAGATTTATATCCACTGAGAACACTGGCCTTATATTAAGGATGATATTACAGTTACAGGTTTTCTTTGTCATTTTTT TAACTACCTCTCATTTTTTAATTTATTAAACATATTTTTTAAAAAAACAAGTTTGGGGGTTTCTTTTTAAATTTATTTTACTTGAAAGGT TGGCATCACAAGTTTCTTTTTCCATAAACTTAAAACATTTCAAAAATGGTTTTTTTAAGCAAGTATGATTTTCTAATTTATATAGAATTC AGGAGACATGAATAAAAGGGCTATTATCTATTCCCTATGCAAATATTTTAACTGTTGCAGTGTTTGACAAAATGGGATTTTTTAAAAATT GCAGAGTAGAAAACAAAATATTCTGTTTACACTGGCGTTGCTGACTATCCTACCATATTCAGCACTTTTAAATACGTTATTTATGAAAAT GCAGTTAAAATGCAAGATAGAAAATATTTATAATAATCATTTCTTTTAACAAATGCCTGTGTTTTCTGAAAGTGTTAGTGTGTTAAGACA TATTTTATTCATGTCATTTAAATACTATTTGAATAAGTTTTCAGTAATATGTTGAAAAAAAGATAGCTATGAAGATGTTTACAAAAAGTC ATATTTTTTCCTAAAGAGTAAAGAAAAACCTAAAAGAATCATCACTTCTATTGTGAAGTTCTATTGTTCCTAAATTATTTAATTTTTTTC TTGCTTAGAATTGAGTTTATTATGCTACTATGATATATACACATGTATGGTGTAGTATCATATTTGTTTCTGTGTGTGAGGCTCAACAAA TTGGTGCACATGACTAGAAAATATGTAATATACTGTGATACACTGCATGCATCCATCTTTTTAAATGTAGACTTTATATTCTCGTTGTTA CTATATATGATGGTGACCTGCTAGTCATAAGTTATCTTTATAAGATACTTTGGACTATTAGATGAATTGTCTGTTTGACAATATCTTTAA TATTTTACCAAATGTAAAAGATAAGGGCCGTTATAAAGAGTCCTAATCTCTAACCTGGGCATTTGTAGAACACAGATTTTAAAGTTGGTA TATCCTTTTGAAACCTGATGAGGAAGTTGAGTTAAAAAAGATTCGAGAGCAGATTTACACATCAGATGTTGATAACCATGCTATGTGAGC ATTTCTGTGCTAAACTCGTATTTTTGGGTGAGGGGAGGGTTTCTCATTTAAGAGTATGTCTGTATATTTGCAACTCTACTAATTTTCTAA GTATGATATAATTCCTTCTGTTTAAGTTACAGAGCTATTATAAATAAACAAAAGAGCCTTCAACTGGTGTCTATGCTACCATTCCAAGAG CACAATATTTGTTTTCTTAGAATTTGAGTTTTCCTAGTGAGTAAATTCCTCCCTGGGGAAAAATTAGCACTTTAAAATGGACACTTTGTG TTTTCAATTGCCAAGGTATCTTTGTATACTATTAGAATTTGCTGATGCACACAGAAAGAGATTAATGCACTTTCTATAGTGCCTAACTTT AGATGTATCTATAAAAGAAAGTAGAGGATACAGATTATGTATATATAAATAAATTGGAGAGCCAGATTTCTTCAGAGATTGATCTTGTAC ATTAATCACACCAGTAATGGATGGATGGCACTTCTTTACTCGGGCTGTTATGATGTTATCCAAAGGTAGTAGAGATGCTCTGACAGTGTT GGAGTGTGCACATGAACAACAAGAGCAAAACACAACTTTGATACTAAAGTTACGAAATGCAGAAGTCAAGACCATAATGTGATGTTTTTT TTTTTTGAAATCTTAAAATATGTACATAGAATGACCAGTTCTGATATGCCGTCTTAGTGCATGGATGTTTATTAGTATCCTTTAATGCTG CCTAGGTTCTGACTTACAGAATGAAATACGTGTTGTTTATCTACCTGATAGTTCAGTTTTGCCAAAGGACTATAGGGATAAGTGAATAAT ATTTATTTATTAGGAGCAAAAATACATTTTCATCCCATTAAGCTAATTTAAAATAATGCCTGATTTTTACTTTTGAGTTTATCCATTTTT CTATACCTTTAACTTATTTATACTTTAAAAAATCATATTGTAATTGTGACAAATTATATCTCAAAAAATACCAATTATTAGATGCTTTGG TGTTGAAATGTAAAAGAGAAGGAATTTAAAATACAATCAAAAAAGTCAAAAATAAAACGTATTTGAAAACCACCTAAAATTTCTTGGCCA GGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAAGCCAAAGAGGGCGGATCACTTGAGCTCAGGAGTTTGAGACCAGACTGGCC AACATGGTGAAACCCCGACTCTAGTAAAAATACAAAATTAGCCGGGCATGGTGGTGGGTGCCTTTAATCCCGGCTACTTGAGAGGCTGAG GCAGGAGAATCGCTTGAACCCAGGAGGCAGAGGTCGCAGTGAGCTGATATCATGCCACTGCACTCCAGCCTTGGCAACAGAGTGACTCCA TCTCAAAATAATAATAATAATTATAATAATAATATTTTTAAGTCTTAGACAGAAAATGCCTATAGATAGAAGCCTATCAAACATGTATTT TGAATACTTTGATCTTGACACATTGCCTAATTATTTTGAAAGATGGTAAAGATATTTCCAAAAAATATTTTCGCCTATCTGTTTACATTG ACAGTTTACAACCATAATTTTCTAAGTATATTTTTCAAACATGTATTTTTGTGTTTTCCATCTTCAAATTTCTGACCAATGGGTTTGTTC TCCTGCAAAAACAATATCCAATCTGCAAAAATTTTTAATTCTTCACTTGCTACAACTGCAAATATTTATCAATAAAACTGATAACCCAAA ACTTGCTTCAGATTTTCCCTGCAGTGCTTAAAATATCCTTGCAACACAAGATGGTGCACAATGACAAGTATTATTTCTGAATACCCAGAT TTGATTTATTTATAGGTATTTTTGAAATTATTACTCTTACAGGTGTAGTCCTCTCCAGCCCCAAGTAACATCTTTTCAGATGAATTCAAG AGGCTGTTCAAGACTTTGACTCTACTGAAAACACTACAAAAGGCAAAATGTTGCCCTAGGTGATAGAAGGTCCCAGTTTGGGAACTGATT TTCTTCCTATGACAAAAGCTATAAGATGAGTAAGGTTACTAATGGAAATGTATGTCCACAGATTCACTTAGGGAGCATAGTGTAAAAACA TCAGGAACTTAAAATTACAAATTTGATTTCAAGTTATATTTCTGTCTCATGTGACTTTGGGCAAATCATTTATCTTCTCTGAGTTCATTT CCTCATCTGCAAATGACAAATAAAATACGTAATTATCAGGATAACTATGAGCATTAAATAAAACAAACGTGGAAAGAATAAAGTGTGGCA TACATTATTATTTTATCAAAGTGCATCACGTCAATAATTGTTATTGTATACTTGTATTAAATGTCACTTTAATGCACTTTCCCCTATTTT TTTCCAAAACATACGTTAAACATCTGATTTAGCTACTCATCAAAACATACAATCATGTTTTAAGATGGAACACTATATCAGTGTTACTGC TTTTCTCAATAATGTGATCCCAAATCAGTACTTTCAGTTCACCATCACCTCAAATCTATAGAAATGTTTCTTTCAATGACATAGATAGAT AGATGATTGATAGATAGATGATAGATAGATGATAAATGGATATACAATTATAGGTTAAAATTAAAGTTTAAATAAGATCAATCATTTGAA AGTTTTATTTCCAAAGGAAATAAAACAACATTCCCAAGGACAGAAATAATATCAAATTACTTGCTAAATATATAAATGAGTTATAGGGCT AAGACTAAGTTATAAGAGATTGACAATTAGAAAACACTCTTTTTAATATTAAGGTGGTATGATTTTCTTTAACAATTTTACAATGAAAAT AAAAACTTAATAAAAGGTGGTAATGGGCCAGGCACGGTGGCTCACGCATACAATCCCAGCACTTTGGGAGACTAAGGCGTGAGGATCACT TGAGCCCAGGAGTTCCAGACATGTCTATGCAACAAAGTGAGACCCTGACTCTAAGAAAAAAATAAAATGTATAAAATTTAAAATAGTAAT GTGTCCATTAAACCTTTTATTTTAGAGTAGTTTTAGATTTACAGAAAAACTCCAAATAGAGAGGTCCCATATACATCTATGGGCATTAAT GAGCCAATATTGATCATTACATTCATACTTCATTCAGATTTCCTTAGTTTATAACCTAATGTCCTTTTTCTGTCCCAGGATCCCATTCAG GATACCACATTACATTTAGTTGTCATGTTTCCTTAGGCTTCCCTTGGCTGTGACAGTTTCTGCAACTTTCCTTGTTTTTGATGACAGTTT TGAGAAATAAACTGGTATTTTGTAGAATGTCCTTCTATGGGGATTCGTCTGATGTTTTTCTCGTGACTAGACACAGGTTTTTGGTTTTTG AAAGAACACAACGGTAAAGTGCCATGCTCATCACATGGTATCAAAGGTATATGCCATCACCGGGACTCGTCTTAGCTGTGACAGTTTCTC AAACTTTAGGCTACTCTTAGCTGTTGATGTTAACCTTGATCACTTAGCTGAGGTAGCATCTATTATATTTCTCCACTGTAAAGTAATGCG TTTTTAAAGAGATTATATTGAAGGTAAATTTTCTGGACATTTACACTGAGCTAAACAAATTCTAAACACTAATATTAGGTTCCACTAAGT GATTACTAATAAATGCTATAAAGAAAATACAGTGAAGTGGAAAAATAAAACTCCAGAAGTCTTAGCCTGAATATTCACCTAATAGAGGTG AAAGTGAATTTTTCCCTTGAACTGTCTGCGCAATTTACAATAATCCTCCACATACTTTGGATATTAAAGATCTTATCTTACTAATTGTCA TAAGAGGTAATTTAAATTTAAACTAACCATTTTGCTTATTGCATTTTTATATTGCCCTCCACTAATCAATGAACACTGAATATTGAAATA ATGTAAAAGACCTATTTCCCGCTAGCTTTAACCGATTTGTCATAAACACCTTTCTTGTATATGATTTTTAAATGTTTGCTAAATATTAAA AAGAATTCAATGTGTTTGGTTTTGTAAAATTACATATCGAATGTGTATAATTTTTTACTACCATGTTCATCACACTTAATCTATATCCAT ATATTGTACTCCACCAATATTTATCAGTGGACAATAAAGAAGTTTTGAATGCATGAATGCAACTTAAGAGGCACCACACTTGGTTATTTT GCAATGCCAGAATAACGGTGGGTATTCACAAATTGAATAGATAATCCAGATTATGTTTCCTCCAATTTAAGTTTTTCTGGGTTTTTTTTT CCCCCTTCCTAGAATCAATTTTATCATTTTACCTATGTACAATAATATACTTCTGGAAAATGCTAGAATTTTCACCATGTAACAGAATTT GAGCATGACAGTAATGTAAAAATATTCAGAAGTCTCGAACTATAGGTTTGAGTTTTCAAAGTAAATCAAAATACAGCTGTTTTCATTTTA CTAGATTGTGGAAACCTATGGATGTTATTGTAAAATGCATATGCATTACACTGACTTTCTTAAAATGTTTTGAATTAATAAAGAATTCAA >55684_55684_2_MTHFD1L-RGS17_MTHFD1L_chr6_151209117_ENST00000367321_RGS17_chr6_153365178_ENST00000367225_length(amino acids)=347AA_BP= MSGTAYQTKVPKAVTSRPAARRPPPSARHGRRVQCPLGAPGTRRKRQVLPAAAAAAAACSPGTRPAALGSRSSVSPENQPSRAMGTRLPL VLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQEKNPAFK PVLAIIQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVDGVTDINL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for MTHFD1L-RGS17 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MTHFD1L-RGS17 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MTHFD1L-RGS17 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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