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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MTHFD1L-THEMIS (FusionGDB2 ID:55687)

Fusion Gene Summary for MTHFD1L-THEMIS

check button Fusion gene summary
Fusion gene informationFusion gene name: MTHFD1L-THEMIS
Fusion gene ID: 55687
HgeneTgene
Gene symbol

MTHFD1L

THEMIS

Gene ID

25902

387357

Gene namemethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 likethymocyte selection associated
SynonymsFTHFSDC1|MTC1THFS|dJ292B18.2C6orf190|C6orf207|GASP|SPOT|TSEPA
Cytomap

6q25.1

6q22.33

Type of geneprotein-codingprotein-coding
Descriptionmonofunctional C1-tetrahydrofolate synthase, mitochondrial10-formyl-THF synthetaseformyltetrahydrofolate synthetase domain containing 1protein THEMISGRB2-associated proteinsignaling phosphoprotein specific for T cellsthymocyte selection pathway associatedthymocyte-expressed molecule involved in selection
Modification date2020031320200313
UniProtAcc

Q6UB35

.
Ensembl transtripts involved in fusion geneENST00000367307, ENST00000367321, 
ENST00000478643, 		ENST00000368248, 
ENST00000368250, ENST00000537166, 
ENST00000543064, 
Fusion gene scores* DoF score11 X 14 X 5=7706 X 7 X 5=210
# samples 1310
** MAII scorelog2(13/770*10)=-2.56634682255381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/210*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MTHFD1L [Title/Abstract] AND THEMIS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMTHFD1L(151355736)-THEMIS(128040968), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMTHFD1L

GO:0006760

folic acid-containing compound metabolic process

12937168

HgeneMTHFD1L

GO:0009257

10-formyltetrahydrofolate biosynthetic process

12937168

HgeneMTHFD1L

GO:0015942

formate metabolic process

16171773


check buttonFusion gene breakpoints across MTHFD1L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across THEMIS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A13Z-01AMTHFD1Lchr6

151355736

-THEMISchr6

128040968

-
ChimerDB4BRCATCGA-D8-A13Z-01AMTHFD1Lchr6

151355736

+THEMISchr6

128040968

-
ChimerDB4BRCATCGA-E9-A248-01AMTHFD1Lchr6

151187185

+THEMISchr6

128176333

-


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Fusion Gene ORF analysis for MTHFD1L-THEMIS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000367307ENST00000368248MTHFD1Lchr6

151187185

+THEMISchr6

128176333

-
5CDS-5UTRENST00000367307ENST00000368250MTHFD1Lchr6

151187185

+THEMISchr6

128176333

-
5CDS-5UTRENST00000367307ENST00000537166MTHFD1Lchr6

151187185

+THEMISchr6

128176333

-
5CDS-5UTRENST00000367307ENST00000543064MTHFD1Lchr6

151187185

+THEMISchr6

128176333

-
5CDS-5UTRENST00000367321ENST00000368248MTHFD1Lchr6

151187185

+THEMISchr6

128176333

-
5CDS-5UTRENST00000367321ENST00000368250MTHFD1Lchr6

151187185

+THEMISchr6

128176333

-
5CDS-5UTRENST00000367321ENST00000537166MTHFD1Lchr6

151187185

+THEMISchr6

128176333

-
5CDS-5UTRENST00000367321ENST00000543064MTHFD1Lchr6

151187185

+THEMISchr6

128176333

-
In-frameENST00000367321ENST00000368248MTHFD1Lchr6

151355736

+THEMISchr6

128040968

-
In-frameENST00000367321ENST00000368250MTHFD1Lchr6

151355736

+THEMISchr6

128040968

-
In-frameENST00000367321ENST00000537166MTHFD1Lchr6

151355736

+THEMISchr6

128040968

-
In-frameENST00000367321ENST00000543064MTHFD1Lchr6

151355736

+THEMISchr6

128040968

-
intron-3CDSENST00000367307ENST00000368248MTHFD1Lchr6

151355736

+THEMISchr6

128040968

-
intron-3CDSENST00000367307ENST00000368250MTHFD1Lchr6

151355736

+THEMISchr6

128040968

-
intron-3CDSENST00000367307ENST00000537166MTHFD1Lchr6

151355736

+THEMISchr6

128040968

-
intron-3CDSENST00000367307ENST00000543064MTHFD1Lchr6

151355736

+THEMISchr6

128040968

-
intron-3CDSENST00000478643ENST00000368248MTHFD1Lchr6

151355736

+THEMISchr6

128040968

-
intron-3CDSENST00000478643ENST00000368250MTHFD1Lchr6

151355736

+THEMISchr6

128040968

-
intron-3CDSENST00000478643ENST00000537166MTHFD1Lchr6

151355736

+THEMISchr6

128040968

-
intron-3CDSENST00000478643ENST00000543064MTHFD1Lchr6

151355736

+THEMISchr6

128040968

-
intron-5UTRENST00000478643ENST00000368248MTHFD1Lchr6

151187185

+THEMISchr6

128176333

-
intron-5UTRENST00000478643ENST00000368250MTHFD1Lchr6

151187185

+THEMISchr6

128176333

-
intron-5UTRENST00000478643ENST00000537166MTHFD1Lchr6

151187185

+THEMISchr6

128176333

-
intron-5UTRENST00000478643ENST00000543064MTHFD1Lchr6

151187185

+THEMISchr6

128176333

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367321MTHFD1Lchr6151355736+ENST00000368250THEMISchr6128040968-504929682531351036
ENST00000367321MTHFD1Lchr6151355736+ENST00000368248THEMISchr6128040968-492729682531351036
ENST00000367321MTHFD1Lchr6151355736+ENST00000543064THEMISchr6128040968-492729682531351036
ENST00000367321MTHFD1Lchr6151355736+ENST00000537166THEMISchr6128040968-492729682531351036

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367321ENST00000368250MTHFD1Lchr6151355736+THEMISchr6128040968-0.0002394620.99976057
ENST00000367321ENST00000368248MTHFD1Lchr6151355736+THEMISchr6128040968-0.0002761230.99972385
ENST00000367321ENST00000543064MTHFD1Lchr6151355736+THEMISchr6128040968-0.0002761230.99972385
ENST00000367321ENST00000537166MTHFD1Lchr6151355736+THEMISchr6128040968-0.0002761230.99972385

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Fusion Genomic Features for MTHFD1L-THEMIS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MTHFD1L-THEMIS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:151355736/chr6:128040968)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTHFD1L

Q6UB35

.
FUNCTION: May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. {ECO:0000250, ECO:0000269|PubMed:16171773}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTHFD1Lchr6:151355736chr6:128040968ENST00000367321+252834_42898932.6666666666666Compositional biasNote=Poly-Gly
HgeneMTHFD1Lchr6:151355736chr6:128040968ENST00000367321+2528423_430898932.6666666666666Nucleotide bindingATP
HgeneMTHFD1Lchr6:151355736chr6:128040968ENST00000367321+252831_348898932.6666666666666RegionNote=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTHFD1Lchr6:151355736chr6:128040968ENST00000367307+1834_420276.0Compositional biasNote=Poly-Gly
HgeneMTHFD1Lchr6:151355736chr6:128040968ENST00000367307+18423_4300276.0Nucleotide bindingATP
HgeneMTHFD1Lchr6:151355736chr6:128040968ENST00000367307+1831_3480276.0RegionNote=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase
HgeneMTHFD1Lchr6:151355736chr6:128040968ENST00000367307+18349_9780276.0RegionNote=Formyltetrahydrofolate synthetase
HgeneMTHFD1Lchr6:151355736chr6:128040968ENST00000367321+2528349_978898932.6666666666666RegionNote=Formyltetrahydrofolate synthetase
TgeneTHEMISchr6:151355736chr6:128040968ENST00000368248361_259586642.0RegionNote=CABIT 1
TgeneTHEMISchr6:151355736chr6:128040968ENST0000036824836260_518586642.0RegionNote=CABIT 2
TgeneTHEMISchr6:151355736chr6:128040968ENST00000537166361_259551607.0RegionNote=CABIT 1
TgeneTHEMISchr6:151355736chr6:128040968ENST0000053716636260_518551607.0RegionNote=CABIT 2


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Fusion Gene Sequence for MTHFD1L-THEMIS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>55687_55687_1_MTHFD1L-THEMIS_MTHFD1L_chr6_151355736_ENST00000367321_THEMIS_chr6_128040968_ENST00000368248_length(transcript)=4927nt_BP=2968nt
TGAGTCCCACTCCGCACCCCACCCTCTGTCTGGTACAGCTTACCAAACCAAAGTGCCCAAAGCCGTGACATCCCGGCCGGCGGCTCGCAG
GCCCCCGCCCTCCGCACGTCACGGCCGCCGGGTGCAGTGCCCCCTAGGGGCCCCTGGGACGAGGAGGAAGCGCCAGGTCCTTCCCGCCGC
CGCCGCCGCCGCCGCCGCCTGCTCCCCTGGCACGCGCCCCGCCGCCCTCGGCAGCCGCAGCTCCGTGTCCCCTGAGAACCAGCCGTCCCG
CGCCATGGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTG
TCGCGCTAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAG
CAGCTGCAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATT
GCAAGAAAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGC
TGAGGAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGATTATAGATGAAATCTTAAAGATCAATGA
AGATACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAACTTGTTTAGCAACAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGT
GGATGGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGGGATGCCCATGAATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGA
ACTTCTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATTTTGGTAGTGGGGGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCT
GTTCCAGAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAAACACGCCAGCTTCAAAGCAAGCTTCACGAGGCTGACATTGTGGTCCT
AGGCTCACCTAAGCCAGAAGAGATTCCCCTTACTTGGATACAACCAGGAACTACTGTTCTCAACTGCTCCCATGACTTCCTGTCAGGGAA
GGTTGGGTGTGGCTCTCCAAGAATACATTTTGGTGGACTCATTGAGGAAGATGATGTGATTCTCCTTGCTGCAGCTCTGCGAATTCAGAA
CATGGTCAGTAGTGGAAGGAGATGGCTTCGTGAACAGCAGCACAGGCGGTGGAGACTTCACTGCTTGAAACTTCAGCCTCTCTCCCCTGT
GCCAAGTGACATTGAGATTTCAAGAGGACAAACTCCAAAAGCTGTGGATGTCCTTGCCAAGGAGATTGGATTGCTTGCAGATGAAATTGA
AATCTATGGCAAAAGCAAAGCCAAAGTACGTTTGTCCGTGCTAGAAAGGTTAAAGGATCAAGCAGATGGAAAATACGTCTTAGTTGCTGG
GATCACACCCACCCCTCTTGGAGAAGGGAAGAGCACAGTCACCATCGGGCTTGTGCAGGCTCTGACCGCACACCTGAATGTCAACTCCTT
TGCCTGCTTGAGGCAGCCTTCCCAAGGACCGACGTTTGGAGTGAAAGGAGGAGCCGCGGGTGGTGGATATGCCCAGGTCATCCCCATGGA
GGAGTTCAACCTTCACTTGACTGGAGACATCCACGCCATCACCGCTGCCAATAACTTGCTGGCTGCCGCCATCGACACGAGGATTCTTCA
TGAAAACACGCAAACAGATAAGGCTCTGTATAATCGGCTGGTTCCTTTAGTGAATGGTGTCAGAGAATTTTCAGAAATTCAGCTTGCTCG
GCTAAAAAAACTGGGAATAAATAAGACTGATCCGAGCACACTGACAGAAGAGGAAGTGAGTAAATTTGCCCGTCTCGACATCGACCCATC
TACCATCACGTGGCAGAGAGTATTGGATACAAATGACCGATTTCTACGAAAAATAACCATCGGGCAGGGAAACACAGAGAAGGGCCATTA
CCGGCAGGCGCAGTTTGACATCGCAGTGGCCAGCGAGATCATGGCGGTGCTGGCCCTGACGGACAGCCTCGCAGACATGAAGGCACGGCT
GGGAAGGATGGTGGTGGCCAGTGACAAAAGCGGGCAGCCTGTGACAGCAGATGATTTGGGGGTGACAGGTGCTTTGACAGTTTTGATGAA
AGATGCAATAAAACCAAACCTGATGCAGACCCTGGAAGGGACACCTGTGTTCGTGCATGCGGGCCCTTTTGCTAACATTGCTCACGGCAA
CTCTTCAGTGTTGGCTGATAAAATTGCCCTGAAACTGGTTGGTGAAGAAGGATTTGTAGTGACCGAAGCTGGCTTTGGTGCTGACATCGG
AATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGAT
GCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTG
TAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGA
GATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGT
GGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGAT
AAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGCG
TCATCACGTAGACATAACCAAGAAACTTCACCCAAATCAAGCTGGCCTGGATTCAAAAGTACTGATTGGTAGTCAGAATGATTTGGTGGA
TGAAGAGAAAGAAAGGAGCAACCGTGGGGCCACAGCAATAGCAGAAACATTCAAAAATGAAAAACATCAAAAATAACAAGATGTGACAGA
AGCCACTTAGGCAGCAAACATAAATGTTGCAGTGAAAAAAGAAGCTAGCCTTCTAGCTGAAAAACGAGTATTCCCCAATGGACTCCAGAA
GAAACTTGATTCATCGCTGCAAAGGAAAGAACAACCTTAAAACTTTTAACAGATAAAACTTACAGAAACCTATGATATAGAATTCATATA
GTCTATTCTGTTGTGTCTAAATCTGTAGGCATTGTGTTGTTGTTCTTTAGGACGTATTTATTTAACTTGCACATTTTTTCAGATTCTTAT
TTCTACTACCAACAACTAAGTAATTGGGAAATAATTCTGTATTTCAGTTTCTGAGTAAAACCAGTCTGAAATAGGATAAAAGCCACCAAA
TATTTTCTTTTTTTTCCAGAATTTGTTTTGCCATTTTTTAGTGCTATCATCATTCCTAACAAGACTAACTTACAGAAAAATAATTATATC
TGACTGATTTAAAATGTTCAGGTTTCTTATCCAAATCCCTTGGAACTATGGAAAGGAGTTTGATTTCACATTCACAGTGTATTTACAAAA
TACGCTGTGTCATAAATATGTTTGAATTCCAACAGCCAAAGCCATTGAGAGTCATAGGAGTTTTCCATAACCTTCTCTTCTATGACCCAA
CAACAAGCTCATGACTGAAATTTCACCAGATTTCTGAGACGATGTCTTAATATTCTATGTGCTATGTACCAGATAATTCTTTAGATGAAT
GTTTCTTAGGATTGTAGGAAAATTATCTAGTTAATCATAATATTTGATGGAAAGAAAAAGACAATAAAATTGTAATATAATAAATTTGGC
TGACAAGAAACCAAAGTGATTCTTAATTAGTATACATCAGAATGATGCTCTTATAGTTGTACCATCTATAAAAATTACTTTAAGGGCTCT
CACATTTTAATAATTTATCTTATTATGTATTAAGTATACAGGAACAATATTATTTTTCCTTTAACAAAATGAAGAGACAGGCTATCTGGT
TAATGTTACATAGGAATTTAATAGTAATGCTTGAACTTCATCCATAGATCATACTCTGTACAAAATTTGTTAGCTAACATCCTATCTCAT
AATTATTTTATGTTTTGTGGAGAAATTTGTTGATTTTGTACCAAAGTGTTTCTGAAGACAATAAATTGTGAGTCAACTTTAGAACAAAAA
AAATTAGAGTTTTTTCAATGTTTATATTCTGATTAAGCTTACTTTACCTTACATTTTTTCTAAGTAACAATGAATCCTGATTTCTAGTGT
CCTAAAAATTGCTTAGTGATTTGATTGTGGTAATATCATTTCTTATCTACAATGTCTAAAGTTTTATGGGACAGTTTTTCTTTTATTTAT
TTTGCCTGTTTGTGCAGATAAGAACAGAAACTTTTCTAAGACCCACATTTGGTTATTGAAGGCCACAGCGAATCTTAACCTAACAGCCTT
GACAAACTGCACCATAGGTGTTTTTAGACTCATATAATTTGTTATTTTTCAAACAATAGTGAATAATTAATATTTTTGTTTGGAATTTGA
GAACAATTAAATTTGTACTTTTAGTAACTACCATTCTTTGATTAGAAAATTAAGAGAATGCATATCTTACTTTGGTTGTAAATTATCAAG
GGCTTTCTAATAGAAATCATATATAACATTTCTAAATATAAGTCCTTTCACATACTGTGTTTCCAGTTGTCTTGATATTGAAAAGTGTAA

>55687_55687_1_MTHFD1L-THEMIS_MTHFD1L_chr6_151355736_ENST00000367321_THEMIS_chr6_128040968_ENST00000368248_length(amino acids)=1036AA_BP=980
MSGTAYQTKVPKAVTSRPAARRPPPSARHGRRVQCPLGAPGTRRKRQVLPAAAAAAAACSPGTRPAALGSRSSVSPENQPSRAMGTRLPL
VLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQEKNPAFK
PVLAIIQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVDGVTDINL
GKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLEAALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPEEI
PLTWIQPGTTVLNCSHDFLSGKVGCGSPRIHFGGLIEEDDVILLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVPSDIEISR
GQTPKAVDVLAKEIGLLADEIEIYGKSKAKVRLSVLERLKDQADGKYVLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSFACLRQPSQ
GPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAIDTRILHENTQTDKALYNRLVPLVNGVREFSEIQLARLKKLGINK
TDPSTLTEEEVSKFARLDIDPSTITWQRVLDTNDRFLRKITIGQGNTEKGHYRQAQFDIAVASEIMAVLALTDSLADMKARLGRMVVASD
KSGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGMEKFFNIK
CRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCELA
KRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQRHHVDITKK

--------------------------------------------------------------
>55687_55687_2_MTHFD1L-THEMIS_MTHFD1L_chr6_151355736_ENST00000367321_THEMIS_chr6_128040968_ENST00000368250_length(transcript)=5049nt_BP=2968nt
TGAGTCCCACTCCGCACCCCACCCTCTGTCTGGTACAGCTTACCAAACCAAAGTGCCCAAAGCCGTGACATCCCGGCCGGCGGCTCGCAG
GCCCCCGCCCTCCGCACGTCACGGCCGCCGGGTGCAGTGCCCCCTAGGGGCCCCTGGGACGAGGAGGAAGCGCCAGGTCCTTCCCGCCGC
CGCCGCCGCCGCCGCCGCCTGCTCCCCTGGCACGCGCCCCGCCGCCCTCGGCAGCCGCAGCTCCGTGTCCCCTGAGAACCAGCCGTCCCG
CGCCATGGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTG
TCGCGCTAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAG
CAGCTGCAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATT
GCAAGAAAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGC
TGAGGAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGATTATAGATGAAATCTTAAAGATCAATGA
AGATACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAACTTGTTTAGCAACAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGT
GGATGGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGGGATGCCCATGAATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGA
ACTTCTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATTTTGGTAGTGGGGGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCT
GTTCCAGAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAAACACGCCAGCTTCAAAGCAAGCTTCACGAGGCTGACATTGTGGTCCT
AGGCTCACCTAAGCCAGAAGAGATTCCCCTTACTTGGATACAACCAGGAACTACTGTTCTCAACTGCTCCCATGACTTCCTGTCAGGGAA
GGTTGGGTGTGGCTCTCCAAGAATACATTTTGGTGGACTCATTGAGGAAGATGATGTGATTCTCCTTGCTGCAGCTCTGCGAATTCAGAA
CATGGTCAGTAGTGGAAGGAGATGGCTTCGTGAACAGCAGCACAGGCGGTGGAGACTTCACTGCTTGAAACTTCAGCCTCTCTCCCCTGT
GCCAAGTGACATTGAGATTTCAAGAGGACAAACTCCAAAAGCTGTGGATGTCCTTGCCAAGGAGATTGGATTGCTTGCAGATGAAATTGA
AATCTATGGCAAAAGCAAAGCCAAAGTACGTTTGTCCGTGCTAGAAAGGTTAAAGGATCAAGCAGATGGAAAATACGTCTTAGTTGCTGG
GATCACACCCACCCCTCTTGGAGAAGGGAAGAGCACAGTCACCATCGGGCTTGTGCAGGCTCTGACCGCACACCTGAATGTCAACTCCTT
TGCCTGCTTGAGGCAGCCTTCCCAAGGACCGACGTTTGGAGTGAAAGGAGGAGCCGCGGGTGGTGGATATGCCCAGGTCATCCCCATGGA
GGAGTTCAACCTTCACTTGACTGGAGACATCCACGCCATCACCGCTGCCAATAACTTGCTGGCTGCCGCCATCGACACGAGGATTCTTCA
TGAAAACACGCAAACAGATAAGGCTCTGTATAATCGGCTGGTTCCTTTAGTGAATGGTGTCAGAGAATTTTCAGAAATTCAGCTTGCTCG
GCTAAAAAAACTGGGAATAAATAAGACTGATCCGAGCACACTGACAGAAGAGGAAGTGAGTAAATTTGCCCGTCTCGACATCGACCCATC
TACCATCACGTGGCAGAGAGTATTGGATACAAATGACCGATTTCTACGAAAAATAACCATCGGGCAGGGAAACACAGAGAAGGGCCATTA
CCGGCAGGCGCAGTTTGACATCGCAGTGGCCAGCGAGATCATGGCGGTGCTGGCCCTGACGGACAGCCTCGCAGACATGAAGGCACGGCT
GGGAAGGATGGTGGTGGCCAGTGACAAAAGCGGGCAGCCTGTGACAGCAGATGATTTGGGGGTGACAGGTGCTTTGACAGTTTTGATGAA
AGATGCAATAAAACCAAACCTGATGCAGACCCTGGAAGGGACACCTGTGTTCGTGCATGCGGGCCCTTTTGCTAACATTGCTCACGGCAA
CTCTTCAGTGTTGGCTGATAAAATTGCCCTGAAACTGGTTGGTGAAGAAGGATTTGTAGTGACCGAAGCTGGCTTTGGTGCTGACATCGG
AATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGAT
GCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTG
TAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGA
GATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGT
GGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGAT
AAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGCG
TCATCACGTAGACATAACCAAGAAACTTCACCCAAATCAAGCTGGCCTGGATTCAAAAGTACTGATTGGTAGTCAGAATGATTTGGTGGA
TGAAGAGAAAGAAAGGAGCAACCGTGGGGCCACAGCAATAGCAGAAACATTCAAAAATGAAAAACATCAAAAATAACAAGATGTGACAGA
AGCCACTTAGGCAGCAAACATAAATGTTGCAGTGAAAAAAGAAGCTAGCCTTCTAGCTGAAAAACGAGTATTCCCCAATGGACTCCAGAA
GAAACTTGATTCATCGCTGCAAAGGAAAGAACAACCTTAAAACTTTTAACAGATAAAACTTACAGAAACCTATGATATAGAATTCATATA
GTCTATTCTGTTGTGTCTAAATCTGTAGGCATTGTGTTGTTGTTCTTTAGGACGTATTTATTTAACTTGCACATTTTTTCAGATTCTTAT
TTCTACTACCAACAACTAAGTAATTGGGAAATAATTCTGTATTTCAGTTTCTGAGTAAAACCAGTCTGAAATAGGATAAAAGCCACCAAA
TATTTTCTTTTTTTTCCAGAATTTGTTTTGCCATTTTTTAGTGCTATCATCATTCCTAACAAGACTAACTTACAGAAAAATAATTATATC
TGACTGATTTAAAATGTTCAGGTTTCTTATCCAAATCCCTTGGAACTATGGAAAGGAGTTTGATTTCACATTCACAGTGTATTTACAAAA
TACGCTGTGTCATAAATATGTTTGAATTCCAACAGCCAAAGCCATTGAGAGTCATAGGAGTTTTCCATAACCTTCTCTTCTATGACCCAA
CAACAAGCTCATGACTGAAATTTCACCAGATTTCTGAGACGATGTCTTAATATTCTATGTGCTATGTACCAGATAATTCTTTAGATGAAT
GTTTCTTAGGATTGTAGGAAAATTATCTAGTTAATCATAATATTTGATGGAAAGAAAAAGACAATAAAATTGTAATATAATAAATTTGGC
TGACAAGAAACCAAAGTGATTCTTAATTAGTATACATCAGAATGATGCTCTTATAGTTGTACCATCTATAAAAATTACTTTAAGGGCTCT
CACATTTTAATAATTTATCTTATTATGTATTAAGTATACAGGAACAATATTATTTTTCCTTTAACAAAATGAAGAGACAGGCTATCTGGT
TAATGTTACATAGGAATTTAATAGTAATGCTTGAACTTCATCCATAGATCATACTCTGTACAAAATTTGTTAGCTAACATCCTATCTCAT
AATTATTTTATGTTTTGTGGAGAAATTTGTTGATTTTGTACCAAAGTGTTTCTGAAGACAATAAATTGTGAGTCAACTTTAGAACAAAAA
AAATTAGAGTTTTTTCAATGTTTATATTCTGATTAAGCTTACTTTACCTTACATTTTTTCTAAGTAACAATGAATCCTGATTTCTAGTGT
CCTAAAAATTGCTTAGTGATTTGATTGTGGTAATATCATTTCTTATCTACAATGTCTAAAGTTTTATGGGACAGTTTTTCTTTTATTTAT
TTTGCCTGTTTGTGCAGATAAGAACAGAAACTTTTCTAAGACCCACATTTGGTTATTGAAGGCCACAGCGAATCTTAACCTAACAGCCTT
GACAAACTGCACCATAGGTGTTTTTAGACTCATATAATTTGTTATTTTTCAAACAATAGTGAATAATTAATATTTTTGTTTGGAATTTGA
GAACAATTAAATTTGTACTTTTAGTAACTACCATTCTTTGATTAGAAAATTAAGAGAATGCATATCTTACTTTGGTTGTAAATTATCAAG
GGCTTTCTAATAGAAATCATATATAACATTTCTAAATATAAGTCCTTTCACATACTGTGTTTCCAGTTGTCTTGATATTGAAAAGTGTAA
TAAACTTCATGCTCACCTATTGGAGATTTGGGAAGGTTGAAAATAAACTTCCTAATTTTTATTTGTATGTGTTCTCTTCTATGTTTAACT
CTAGAATAACTATCTTCCTGTAACGATTAAGTTAAAATATTCTTTAACTAGAATTGAAATAAATTGTTCACTAAGGAGGGGGCTGCTTGT

>55687_55687_2_MTHFD1L-THEMIS_MTHFD1L_chr6_151355736_ENST00000367321_THEMIS_chr6_128040968_ENST00000368250_length(amino acids)=1036AA_BP=980
MSGTAYQTKVPKAVTSRPAARRPPPSARHGRRVQCPLGAPGTRRKRQVLPAAAAAAAACSPGTRPAALGSRSSVSPENQPSRAMGTRLPL
VLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQEKNPAFK
PVLAIIQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVDGVTDINL
GKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLEAALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPEEI
PLTWIQPGTTVLNCSHDFLSGKVGCGSPRIHFGGLIEEDDVILLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVPSDIEISR
GQTPKAVDVLAKEIGLLADEIEIYGKSKAKVRLSVLERLKDQADGKYVLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSFACLRQPSQ
GPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAIDTRILHENTQTDKALYNRLVPLVNGVREFSEIQLARLKKLGINK
TDPSTLTEEEVSKFARLDIDPSTITWQRVLDTNDRFLRKITIGQGNTEKGHYRQAQFDIAVASEIMAVLALTDSLADMKARLGRMVVASD
KSGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGMEKFFNIK
CRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCELA
KRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQRHHVDITKK

--------------------------------------------------------------
>55687_55687_3_MTHFD1L-THEMIS_MTHFD1L_chr6_151355736_ENST00000367321_THEMIS_chr6_128040968_ENST00000537166_length(transcript)=4927nt_BP=2968nt
TGAGTCCCACTCCGCACCCCACCCTCTGTCTGGTACAGCTTACCAAACCAAAGTGCCCAAAGCCGTGACATCCCGGCCGGCGGCTCGCAG
GCCCCCGCCCTCCGCACGTCACGGCCGCCGGGTGCAGTGCCCCCTAGGGGCCCCTGGGACGAGGAGGAAGCGCCAGGTCCTTCCCGCCGC
CGCCGCCGCCGCCGCCGCCTGCTCCCCTGGCACGCGCCCCGCCGCCCTCGGCAGCCGCAGCTCCGTGTCCCCTGAGAACCAGCCGTCCCG
CGCCATGGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTG
TCGCGCTAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAG
CAGCTGCAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATT
GCAAGAAAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGC
TGAGGAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGATTATAGATGAAATCTTAAAGATCAATGA
AGATACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAACTTGTTTAGCAACAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGT
GGATGGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGGGATGCCCATGAATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGA
ACTTCTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATTTTGGTAGTGGGGGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCT
GTTCCAGAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAAACACGCCAGCTTCAAAGCAAGCTTCACGAGGCTGACATTGTGGTCCT
AGGCTCACCTAAGCCAGAAGAGATTCCCCTTACTTGGATACAACCAGGAACTACTGTTCTCAACTGCTCCCATGACTTCCTGTCAGGGAA
GGTTGGGTGTGGCTCTCCAAGAATACATTTTGGTGGACTCATTGAGGAAGATGATGTGATTCTCCTTGCTGCAGCTCTGCGAATTCAGAA
CATGGTCAGTAGTGGAAGGAGATGGCTTCGTGAACAGCAGCACAGGCGGTGGAGACTTCACTGCTTGAAACTTCAGCCTCTCTCCCCTGT
GCCAAGTGACATTGAGATTTCAAGAGGACAAACTCCAAAAGCTGTGGATGTCCTTGCCAAGGAGATTGGATTGCTTGCAGATGAAATTGA
AATCTATGGCAAAAGCAAAGCCAAAGTACGTTTGTCCGTGCTAGAAAGGTTAAAGGATCAAGCAGATGGAAAATACGTCTTAGTTGCTGG
GATCACACCCACCCCTCTTGGAGAAGGGAAGAGCACAGTCACCATCGGGCTTGTGCAGGCTCTGACCGCACACCTGAATGTCAACTCCTT
TGCCTGCTTGAGGCAGCCTTCCCAAGGACCGACGTTTGGAGTGAAAGGAGGAGCCGCGGGTGGTGGATATGCCCAGGTCATCCCCATGGA
GGAGTTCAACCTTCACTTGACTGGAGACATCCACGCCATCACCGCTGCCAATAACTTGCTGGCTGCCGCCATCGACACGAGGATTCTTCA
TGAAAACACGCAAACAGATAAGGCTCTGTATAATCGGCTGGTTCCTTTAGTGAATGGTGTCAGAGAATTTTCAGAAATTCAGCTTGCTCG
GCTAAAAAAACTGGGAATAAATAAGACTGATCCGAGCACACTGACAGAAGAGGAAGTGAGTAAATTTGCCCGTCTCGACATCGACCCATC
TACCATCACGTGGCAGAGAGTATTGGATACAAATGACCGATTTCTACGAAAAATAACCATCGGGCAGGGAAACACAGAGAAGGGCCATTA
CCGGCAGGCGCAGTTTGACATCGCAGTGGCCAGCGAGATCATGGCGGTGCTGGCCCTGACGGACAGCCTCGCAGACATGAAGGCACGGCT
GGGAAGGATGGTGGTGGCCAGTGACAAAAGCGGGCAGCCTGTGACAGCAGATGATTTGGGGGTGACAGGTGCTTTGACAGTTTTGATGAA
AGATGCAATAAAACCAAACCTGATGCAGACCCTGGAAGGGACACCTGTGTTCGTGCATGCGGGCCCTTTTGCTAACATTGCTCACGGCAA
CTCTTCAGTGTTGGCTGATAAAATTGCCCTGAAACTGGTTGGTGAAGAAGGATTTGTAGTGACCGAAGCTGGCTTTGGTGCTGACATCGG
AATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGAT
GCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTG
TAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGA
GATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGT
GGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGAT
AAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGCG
TCATCACGTAGACATAACCAAGAAACTTCACCCAAATCAAGCTGGCCTGGATTCAAAAGTACTGATTGGTAGTCAGAATGATTTGGTGGA
TGAAGAGAAAGAAAGGAGCAACCGTGGGGCCACAGCAATAGCAGAAACATTCAAAAATGAAAAACATCAAAAATAACAAGATGTGACAGA
AGCCACTTAGGCAGCAAACATAAATGTTGCAGTGAAAAAAGAAGCTAGCCTTCTAGCTGAAAAACGAGTATTCCCCAATGGACTCCAGAA
GAAACTTGATTCATCGCTGCAAAGGAAAGAACAACCTTAAAACTTTTAACAGATAAAACTTACAGAAACCTATGATATAGAATTCATATA
GTCTATTCTGTTGTGTCTAAATCTGTAGGCATTGTGTTGTTGTTCTTTAGGACGTATTTATTTAACTTGCACATTTTTTCAGATTCTTAT
TTCTACTACCAACAACTAAGTAATTGGGAAATAATTCTGTATTTCAGTTTCTGAGTAAAACCAGTCTGAAATAGGATAAAAGCCACCAAA
TATTTTCTTTTTTTTCCAGAATTTGTTTTGCCATTTTTTAGTGCTATCATCATTCCTAACAAGACTAACTTACAGAAAAATAATTATATC
TGACTGATTTAAAATGTTCAGGTTTCTTATCCAAATCCCTTGGAACTATGGAAAGGAGTTTGATTTCACATTCACAGTGTATTTACAAAA
TACGCTGTGTCATAAATATGTTTGAATTCCAACAGCCAAAGCCATTGAGAGTCATAGGAGTTTTCCATAACCTTCTCTTCTATGACCCAA
CAACAAGCTCATGACTGAAATTTCACCAGATTTCTGAGACGATGTCTTAATATTCTATGTGCTATGTACCAGATAATTCTTTAGATGAAT
GTTTCTTAGGATTGTAGGAAAATTATCTAGTTAATCATAATATTTGATGGAAAGAAAAAGACAATAAAATTGTAATATAATAAATTTGGC
TGACAAGAAACCAAAGTGATTCTTAATTAGTATACATCAGAATGATGCTCTTATAGTTGTACCATCTATAAAAATTACTTTAAGGGCTCT
CACATTTTAATAATTTATCTTATTATGTATTAAGTATACAGGAACAATATTATTTTTCCTTTAACAAAATGAAGAGACAGGCTATCTGGT
TAATGTTACATAGGAATTTAATAGTAATGCTTGAACTTCATCCATAGATCATACTCTGTACAAAATTTGTTAGCTAACATCCTATCTCAT
AATTATTTTATGTTTTGTGGAGAAATTTGTTGATTTTGTACCAAAGTGTTTCTGAAGACAATAAATTGTGAGTCAACTTTAGAACAAAAA
AAATTAGAGTTTTTTCAATGTTTATATTCTGATTAAGCTTACTTTACCTTACATTTTTTCTAAGTAACAATGAATCCTGATTTCTAGTGT
CCTAAAAATTGCTTAGTGATTTGATTGTGGTAATATCATTTCTTATCTACAATGTCTAAAGTTTTATGGGACAGTTTTTCTTTTATTTAT
TTTGCCTGTTTGTGCAGATAAGAACAGAAACTTTTCTAAGACCCACATTTGGTTATTGAAGGCCACAGCGAATCTTAACCTAACAGCCTT
GACAAACTGCACCATAGGTGTTTTTAGACTCATATAATTTGTTATTTTTCAAACAATAGTGAATAATTAATATTTTTGTTTGGAATTTGA
GAACAATTAAATTTGTACTTTTAGTAACTACCATTCTTTGATTAGAAAATTAAGAGAATGCATATCTTACTTTGGTTGTAAATTATCAAG
GGCTTTCTAATAGAAATCATATATAACATTTCTAAATATAAGTCCTTTCACATACTGTGTTTCCAGTTGTCTTGATATTGAAAAGTGTAA

>55687_55687_3_MTHFD1L-THEMIS_MTHFD1L_chr6_151355736_ENST00000367321_THEMIS_chr6_128040968_ENST00000537166_length(amino acids)=1036AA_BP=980
MSGTAYQTKVPKAVTSRPAARRPPPSARHGRRVQCPLGAPGTRRKRQVLPAAAAAAAACSPGTRPAALGSRSSVSPENQPSRAMGTRLPL
VLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQEKNPAFK
PVLAIIQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVDGVTDINL
GKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLEAALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPEEI
PLTWIQPGTTVLNCSHDFLSGKVGCGSPRIHFGGLIEEDDVILLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVPSDIEISR
GQTPKAVDVLAKEIGLLADEIEIYGKSKAKVRLSVLERLKDQADGKYVLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSFACLRQPSQ
GPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAIDTRILHENTQTDKALYNRLVPLVNGVREFSEIQLARLKKLGINK
TDPSTLTEEEVSKFARLDIDPSTITWQRVLDTNDRFLRKITIGQGNTEKGHYRQAQFDIAVASEIMAVLALTDSLADMKARLGRMVVASD
KSGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGMEKFFNIK
CRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCELA
KRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQRHHVDITKK

--------------------------------------------------------------
>55687_55687_4_MTHFD1L-THEMIS_MTHFD1L_chr6_151355736_ENST00000367321_THEMIS_chr6_128040968_ENST00000543064_length(transcript)=4927nt_BP=2968nt
TGAGTCCCACTCCGCACCCCACCCTCTGTCTGGTACAGCTTACCAAACCAAAGTGCCCAAAGCCGTGACATCCCGGCCGGCGGCTCGCAG
GCCCCCGCCCTCCGCACGTCACGGCCGCCGGGTGCAGTGCCCCCTAGGGGCCCCTGGGACGAGGAGGAAGCGCCAGGTCCTTCCCGCCGC
CGCCGCCGCCGCCGCCGCCTGCTCCCCTGGCACGCGCCCCGCCGCCCTCGGCAGCCGCAGCTCCGTGTCCCCTGAGAACCAGCCGTCCCG
CGCCATGGGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCTCCGCGCCGCCTCCGTGTGCCCTG
TCGCGCTAGCAGCGGCGGCGGCGGAGGCGGCGGCGGTGGCCGGGAGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCGGAG
CAGCTGCAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGTCATTCAGAATTCAAAAGAAGTTCTAAGTTTATT
GCAAGAAAAAAACCCTGCCTTCAAGCCGGTTCTTGCAATTATCCAGGCAGGTGACGACAACTTGATGCAGGAAATCAACCAGAATTTGGC
TGAGGAGGCTGGTCTGAACATCACTCACATTTGCCTCCCTCCAGATAGCAGTGAAGCCGAGATTATAGATGAAATCTTAAAGATCAATGA
AGATACCAGAGTACATGGCCTTGCCCTTCAGATCTCTGAGAACTTGTTTAGCAACAAAGTCCTCAATGCCTTGAAACCAGAAAAAGATGT
GGATGGAGTAACAGACATAAACCTGGGGAAGCTGGTGCGAGGGGATGCCCATGAATGTTTTGTTTCACCTGTTGCCAAAGCTGTAATTGA
ACTTCTTGAAAAATCAGGTGTCAACCTAGATGGAAAGAAGATTTTGGTAGTGGGGGCCCATGGGTCTTTGGAAGCTGCTCTACAATGCCT
GTTCCAGAGAAAAGGGTCCATGACAATGAGCATCCAGTGGAAAACACGCCAGCTTCAAAGCAAGCTTCACGAGGCTGACATTGTGGTCCT
AGGCTCACCTAAGCCAGAAGAGATTCCCCTTACTTGGATACAACCAGGAACTACTGTTCTCAACTGCTCCCATGACTTCCTGTCAGGGAA
GGTTGGGTGTGGCTCTCCAAGAATACATTTTGGTGGACTCATTGAGGAAGATGATGTGATTCTCCTTGCTGCAGCTCTGCGAATTCAGAA
CATGGTCAGTAGTGGAAGGAGATGGCTTCGTGAACAGCAGCACAGGCGGTGGAGACTTCACTGCTTGAAACTTCAGCCTCTCTCCCCTGT
GCCAAGTGACATTGAGATTTCAAGAGGACAAACTCCAAAAGCTGTGGATGTCCTTGCCAAGGAGATTGGATTGCTTGCAGATGAAATTGA
AATCTATGGCAAAAGCAAAGCCAAAGTACGTTTGTCCGTGCTAGAAAGGTTAAAGGATCAAGCAGATGGAAAATACGTCTTAGTTGCTGG
GATCACACCCACCCCTCTTGGAGAAGGGAAGAGCACAGTCACCATCGGGCTTGTGCAGGCTCTGACCGCACACCTGAATGTCAACTCCTT
TGCCTGCTTGAGGCAGCCTTCCCAAGGACCGACGTTTGGAGTGAAAGGAGGAGCCGCGGGTGGTGGATATGCCCAGGTCATCCCCATGGA
GGAGTTCAACCTTCACTTGACTGGAGACATCCACGCCATCACCGCTGCCAATAACTTGCTGGCTGCCGCCATCGACACGAGGATTCTTCA
TGAAAACACGCAAACAGATAAGGCTCTGTATAATCGGCTGGTTCCTTTAGTGAATGGTGTCAGAGAATTTTCAGAAATTCAGCTTGCTCG
GCTAAAAAAACTGGGAATAAATAAGACTGATCCGAGCACACTGACAGAAGAGGAAGTGAGTAAATTTGCCCGTCTCGACATCGACCCATC
TACCATCACGTGGCAGAGAGTATTGGATACAAATGACCGATTTCTACGAAAAATAACCATCGGGCAGGGAAACACAGAGAAGGGCCATTA
CCGGCAGGCGCAGTTTGACATCGCAGTGGCCAGCGAGATCATGGCGGTGCTGGCCCTGACGGACAGCCTCGCAGACATGAAGGCACGGCT
GGGAAGGATGGTGGTGGCCAGTGACAAAAGCGGGCAGCCTGTGACAGCAGATGATTTGGGGGTGACAGGTGCTTTGACAGTTTTGATGAA
AGATGCAATAAAACCAAACCTGATGCAGACCCTGGAAGGGACACCTGTGTTCGTGCATGCGGGCCCTTTTGCTAACATTGCTCACGGCAA
CTCTTCAGTGTTGGCTGATAAAATTGCCCTGAAACTGGTTGGTGAAGAAGGATTTGTAGTGACCGAAGCTGGCTTTGGTGCTGACATCGG
AATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGAT
GCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTG
TAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGA
GATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGT
GGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGAT
AAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGCG
TCATCACGTAGACATAACCAAGAAACTTCACCCAAATCAAGCTGGCCTGGATTCAAAAGTACTGATTGGTAGTCAGAATGATTTGGTGGA
TGAAGAGAAAGAAAGGAGCAACCGTGGGGCCACAGCAATAGCAGAAACATTCAAAAATGAAAAACATCAAAAATAACAAGATGTGACAGA
AGCCACTTAGGCAGCAAACATAAATGTTGCAGTGAAAAAAGAAGCTAGCCTTCTAGCTGAAAAACGAGTATTCCCCAATGGACTCCAGAA
GAAACTTGATTCATCGCTGCAAAGGAAAGAACAACCTTAAAACTTTTAACAGATAAAACTTACAGAAACCTATGATATAGAATTCATATA
GTCTATTCTGTTGTGTCTAAATCTGTAGGCATTGTGTTGTTGTTCTTTAGGACGTATTTATTTAACTTGCACATTTTTTCAGATTCTTAT
TTCTACTACCAACAACTAAGTAATTGGGAAATAATTCTGTATTTCAGTTTCTGAGTAAAACCAGTCTGAAATAGGATAAAAGCCACCAAA
TATTTTCTTTTTTTTCCAGAATTTGTTTTGCCATTTTTTAGTGCTATCATCATTCCTAACAAGACTAACTTACAGAAAAATAATTATATC
TGACTGATTTAAAATGTTCAGGTTTCTTATCCAAATCCCTTGGAACTATGGAAAGGAGTTTGATTTCACATTCACAGTGTATTTACAAAA
TACGCTGTGTCATAAATATGTTTGAATTCCAACAGCCAAAGCCATTGAGAGTCATAGGAGTTTTCCATAACCTTCTCTTCTATGACCCAA
CAACAAGCTCATGACTGAAATTTCACCAGATTTCTGAGACGATGTCTTAATATTCTATGTGCTATGTACCAGATAATTCTTTAGATGAAT
GTTTCTTAGGATTGTAGGAAAATTATCTAGTTAATCATAATATTTGATGGAAAGAAAAAGACAATAAAATTGTAATATAATAAATTTGGC
TGACAAGAAACCAAAGTGATTCTTAATTAGTATACATCAGAATGATGCTCTTATAGTTGTACCATCTATAAAAATTACTTTAAGGGCTCT
CACATTTTAATAATTTATCTTATTATGTATTAAGTATACAGGAACAATATTATTTTTCCTTTAACAAAATGAAGAGACAGGCTATCTGGT
TAATGTTACATAGGAATTTAATAGTAATGCTTGAACTTCATCCATAGATCATACTCTGTACAAAATTTGTTAGCTAACATCCTATCTCAT
AATTATTTTATGTTTTGTGGAGAAATTTGTTGATTTTGTACCAAAGTGTTTCTGAAGACAATAAATTGTGAGTCAACTTTAGAACAAAAA
AAATTAGAGTTTTTTCAATGTTTATATTCTGATTAAGCTTACTTTACCTTACATTTTTTCTAAGTAACAATGAATCCTGATTTCTAGTGT
CCTAAAAATTGCTTAGTGATTTGATTGTGGTAATATCATTTCTTATCTACAATGTCTAAAGTTTTATGGGACAGTTTTTCTTTTATTTAT
TTTGCCTGTTTGTGCAGATAAGAACAGAAACTTTTCTAAGACCCACATTTGGTTATTGAAGGCCACAGCGAATCTTAACCTAACAGCCTT
GACAAACTGCACCATAGGTGTTTTTAGACTCATATAATTTGTTATTTTTCAAACAATAGTGAATAATTAATATTTTTGTTTGGAATTTGA
GAACAATTAAATTTGTACTTTTAGTAACTACCATTCTTTGATTAGAAAATTAAGAGAATGCATATCTTACTTTGGTTGTAAATTATCAAG
GGCTTTCTAATAGAAATCATATATAACATTTCTAAATATAAGTCCTTTCACATACTGTGTTTCCAGTTGTCTTGATATTGAAAAGTGTAA

>55687_55687_4_MTHFD1L-THEMIS_MTHFD1L_chr6_151355736_ENST00000367321_THEMIS_chr6_128040968_ENST00000543064_length(amino acids)=1036AA_BP=980
MSGTAYQTKVPKAVTSRPAARRPPPSARHGRRVQCPLGAPGTRRKRQVLPAAAAAAAACSPGTRPAALGSRSSVSPENQPSRAMGTRLPL
VLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQEKNPAFK
PVLAIIQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVDGVTDINL
GKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLEAALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPEEI
PLTWIQPGTTVLNCSHDFLSGKVGCGSPRIHFGGLIEEDDVILLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVPSDIEISR
GQTPKAVDVLAKEIGLLADEIEIYGKSKAKVRLSVLERLKDQADGKYVLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSFACLRQPSQ
GPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAIDTRILHENTQTDKALYNRLVPLVNGVREFSEIQLARLKKLGINK
TDPSTLTEEEVSKFARLDIDPSTITWQRVLDTNDRFLRKITIGQGNTEKGHYRQAQFDIAVASEIMAVLALTDSLADMKARLGRMVVASD
KSGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGMEKFFNIK
CRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCELA
KRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQRHHVDITKK

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Fusion Gene PPI Analysis for MTHFD1L-THEMIS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MTHFD1L-THEMIS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MTHFD1L-THEMIS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource