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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MTIF2-PPP3R1 (FusionGDB2 ID:55702)

Fusion Gene Summary for MTIF2-PPP3R1

Fusion gene summary

Fusion gene information	Fusion gene name: MTIF2-PPP3R1
	Fusion gene ID: 55702
		Hgene	Tgene
	Gene symbol	MTIF2	PPP3R1
	Gene ID	4528	5534
	Gene name	mitochondrial translational initiation factor 2	protein phosphatase 3 regulatory subunit B, alpha
	Synonyms	-	CALNB1\|CNB\|CNB1
	Cytomap	2p16.1	2p14
	Type of gene	protein-coding	protein-coding
	Description	translation initiation factor IF-2, mitochondrialIF-2mt	calcineurin subunit B type 1calcineurin B, type I (19kDa)protein phosphatase 2B regulatory subunit 1protein phosphatase 2B regulatory subunit B alphaprotein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000446660, ENST00000263629, ENST00000403721, ENST00000394600,	ENST00000234310, ENST00000409377, ENST00000409752,
Fusion gene scores	* DoF score	6 X 8 X 4=192	5 X 4 X 4=80
	# samples	11	6
	** MAII score	log2(11/192*10)=-0.803602787196497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MTIF2 [Title/Abstract] AND PPP3R1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MTIF2(55489452)-PPP3R1(68415822), # samples:2
Anticipated loss of major functional domain due to fusion event.	MTIF2-PPP3R1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. MTIF2-PPP3R1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PPP3R1	GO:0033173	calcineurin-NFAT signaling cascade	22688515
Tgene	PPP3R1	GO:0045944	positive regulation of transcription by RNA polymerase II	22688515

Fusion gene breakpoints across MTIF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PPP3R1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-CC-A3MB-01A	MTIF2	chr2	55489452	-	PPP3R1	chr2	68415822	-

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Fusion Gene ORF analysis for MTIF2-PPP3R1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000446660	ENST00000234310	MTIF2	chr2	55489452	-	PPP3R1	chr2	68415822	-
5UTR-3CDS	ENST00000446660	ENST00000409377	MTIF2	chr2	55489452	-	PPP3R1	chr2	68415822	-
5UTR-3CDS	ENST00000446660	ENST00000409752	MTIF2	chr2	55489452	-	PPP3R1	chr2	68415822	-
Frame-shift	ENST00000263629	ENST00000234310	MTIF2	chr2	55489452	-	PPP3R1	chr2	68415822	-
Frame-shift	ENST00000263629	ENST00000409377	MTIF2	chr2	55489452	-	PPP3R1	chr2	68415822	-
Frame-shift	ENST00000263629	ENST00000409752	MTIF2	chr2	55489452	-	PPP3R1	chr2	68415822	-
Frame-shift	ENST00000403721	ENST00000234310	MTIF2	chr2	55489452	-	PPP3R1	chr2	68415822	-
Frame-shift	ENST00000403721	ENST00000409377	MTIF2	chr2	55489452	-	PPP3R1	chr2	68415822	-
Frame-shift	ENST00000403721	ENST00000409752	MTIF2	chr2	55489452	-	PPP3R1	chr2	68415822	-
In-frame	ENST00000394600	ENST00000234310	MTIF2	chr2	55489452	-	PPP3R1	chr2	68415822	-
In-frame	ENST00000394600	ENST00000409377	MTIF2	chr2	55489452	-	PPP3R1	chr2	68415822	-
In-frame	ENST00000394600	ENST00000409752	MTIF2	chr2	55489452	-	PPP3R1	chr2	68415822	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000394600	MTIF2	chr2	55489452	-	ENST00000234310	PPP3R1	chr2	68415822	-	3644	1068	698	1537	279
ENST00000394600	MTIF2	chr2	55489452	-	ENST00000409752	PPP3R1	chr2	68415822	-	1697	1068	698	1537	279
ENST00000394600	MTIF2	chr2	55489452	-	ENST00000409377	PPP3R1	chr2	68415822	-	1554	1068	698	1537	279

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000394600	ENST00000234310	MTIF2	chr2	55489452	-	PPP3R1	chr2	68415822	-	0.000695327	0.99930465
ENST00000394600	ENST00000409752	MTIF2	chr2	55489452	-	PPP3R1	chr2	68415822	-	0.001590854	0.9984092
ENST00000394600	ENST00000409377	MTIF2	chr2	55489452	-	PPP3R1	chr2	68415822	-	0.001879669	0.99812037

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Fusion Genomic Features for MTIF2-PPP3R1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MTIF2-PPP3R1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:55489452/chr2:68415822)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PPP3R1

chr2:55489452

chr2:68415822

ENST00000234310

100_111

171.0

Calcium binding

Tgene

PPP3R1

chr2:55489452

chr2:68415822

ENST00000234310

141_152

171.0

Calcium binding

Tgene

PPP3R1

chr2:55489452

chr2:68415822

ENST00000234310

31_42

171.0

Calcium binding

Tgene

PPP3R1

chr2:55489452

chr2:68415822

ENST00000234310

63_74

171.0

Calcium binding

Tgene

PPP3R1

chr2:55489452

chr2:68415822

ENST00000234310

128_163

171.0

Domain

EF-hand 4

Tgene

PPP3R1

chr2:55489452

chr2:68415822

ENST00000234310

18_51

171.0

Domain

EF-hand 1

Tgene

PPP3R1

chr2:55489452

chr2:68415822

ENST00000234310

50_85

171.0

Domain

EF-hand 2

Tgene

PPP3R1

chr2:55489452

chr2:68415822

ENST00000234310

87_122

171.0

Domain

EF-hand 3

Tgene

PPP3R1

chr2:55489452

chr2:68415822

ENST00000234310

131_136

171.0

Region

Calcineurin A binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MTIF2

chr2:55489452

chr2:68415822

ENST00000263629

178_348

110

728.0

Domain

Note=tr-type G

Hgene

MTIF2

chr2:55489452

chr2:68415822

ENST00000394600

178_348

110

728.0

Domain

Note=tr-type G

Hgene

MTIF2

chr2:55489452

chr2:68415822

ENST00000403721

178_348

110

728.0

Domain

Note=tr-type G

Hgene

MTIF2

chr2:55489452

chr2:68415822

ENST00000263629

187_194

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:68415822

ENST00000263629

212_216

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:68415822

ENST00000263629

234_237

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:68415822

ENST00000263629

288_291

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:68415822

ENST00000263629

324_326

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:68415822

ENST00000394600

187_194

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:68415822

ENST00000394600

212_216

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:68415822

ENST00000394600

234_237

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:68415822

ENST00000394600

288_291

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:68415822

ENST00000394600

324_326

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:68415822

ENST00000403721

187_194

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:68415822

ENST00000403721

212_216

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:68415822

ENST00000403721

234_237

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:68415822

ENST00000403721

288_291

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:68415822

ENST00000403721

324_326

110

728.0

Region

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Fusion Gene Sequence for MTIF2-PPP3R1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>55702_55702_1_MTIF2-PPP3R1_MTIF2_chr2_55489452_ENST00000394600_PPP3R1_chr2_68415822_ENST00000234310_length(transcript)=3644nt_BP=1068nt
CGGGGCTGTAGGTAGGAGTTAAGTGGGTAGGATCCCTTAACCAGGGTTGTCCGGTGCAGGTGGTGTGTGTTGTTTCGCCTAACGTGTCAG
TGGCACAAATCACGCGAACTTCATAAACATTGTGCGTTCGGAAGCCTTTCCAAGATGCATTTAATCCCTGCGTGAGCCCACGTTAGGCAT
TCACGAAGGCATGTGCACTGTTCTCTCGGAAGCGGCTGGCCGGCTTCCCCTCCTCGCGCGCGGCTGTGGGTGCAGGTCCTCACTTCCCAG
CCTCCCATGGGCCCAAGGCCTTCTGGGCTCCAATTTGAGGCGAGCCACCCCAGATCCGTAATTTTTCTGCAGTGATTTATTTTTACCTTT
CTGATTCCTTGACAAGGATATCCTAGCGGCGAAACAACACCGTACTGGGAGTCAGAACGTCTGGGTTCTAGTCTTGACTGCCATTAACTA
GCGGTATGACATTGGAGAAGCTTTTTTGACCCTTCTGGATTTCCGTTTCCTTTTCTGTAAAATGAGGAGCTTGGAAGATCCGGAAAATGA
GGCCCATAGGAAACAAGTGACTTGCTGAGTCCAGATAACACTGACTGTCAGAAGTCTCGCTCTGTCTCCCCGGCTGGAGTGCAGTGGCGT
GATCTTGGCTCACTGCAACCTCTGTCTCCCGGGTTCAAGAAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCA
CCACGCCCAGGAGAAACATGAACCAGAAGCTACTGAAGTTGGAGAACTTGCTACGATTTCACACTATTTATAGGCAACTGCACAGTCTGT
GTCAAAGAAGAGCATTAAGACAGTGGAGGCATGGGTTTTCATCTGCTTACCCTGTGTGGACAGCTCAACTGTGTGCCTGGCCCTGGCCAA
CAGATGTGCTCACTGGGGCTGCTTTATCTCAGTATAGGCTTCTAGTAACAAAAAAGGAAGAAGGACCATGGAAATCTCAGTTATCTTCAA
CAAAATCTAAAAAGGTGGTAGAAGTATGGATTGGAATGACTATTGAGGAACTGGCCAGGGCAATGGAAAAAAACACAGTTGATGCGGATG
AAATTAAAAGGCTAGGAAAGAGATTTAAGAAGCTTGATTTGGACAATTCTGGTTCTTTGAGTGTGGAAGAGTTCATGTCTCTGCCTGAGT
TACAACAGAATCCTTTAGTACAGCGAGTAATAGATATATTCGACACAGATGGGAATGGAGAAGTAGACTTTAAAGAATTCATTGAGGGCG
TCTCTCAGTTCAGTGTCAAAGGAGATAAGGAGCAGAAATTGAGGTTTGCTTTCCGTATCTATGACATGGATAAAGATGGCTATATTTCCA
ATGGGGAACTCTTCCAGGTATTGAAGATGATGGTGGGGAACAATCTGAAAGATACACAGTTACAGCAAATTGTAGACAAAACCATAATAA
ATGCAGATAAGGATGGAGATGGAAGAATATCCTTTGAAGAATTCTGTGCTGTTGTAGGTGGCCTAGATATCCACAAAAAGATGGTGGTAG
ATGTGTGACTCTTATCAGAGAGTACCACCCAACACTTTTGCTTTCTTCTCCATCTCTGAAGATCTGCTCAAGACGTCCAGCAATGCTCTC
TGTGTATTTAAATGGAAGTATTTTTCTCTGTGAAGCCACATTTTCCAACATGAGCCTCATGAAGCCAACTAAGTGTTATTGAACTGTAAT
TCTCTCAATAACTCAGTGTAGCACTTTAAAGTCTGAAGGACAGCAACATGAAAAGAGCATATCAATGTGGTGGAGAAAGGGAAGGGGTTG
GCTTTTTAATTTATTTTTCTTCATCTTTTATAACAAGAAAGTATCTATATATACATATGTAAATATTTATATATAGATATATGTAGCTTT
CTATATATGTAGTAGGTTGGCTTTAATTTAATATACTTGATTCAGAAACAAAACAATAGAGTACAAAAGTGCCAAGCAGAACATAAAACA
TCCTTACTTTTATTTCACACAGTTTTATATATAGATAGAAGACTGTACAATTTGAGCCGGGTGTTAGGCCAGCTATTTTCCTTTTCCTGT
GCTTTCTCCTTTGAGAGATTGACAAAGCATTTGTTAACGTCCTATTATTTACCTTAATTACATTTTTGTAACAAAGGAGTCTGTAACTTT
ATTTATACTTATGAATATATCCAGGGACTACTTCTCATTGCTGAGCAGCTTTTAATACACCTCTGCTTGAGGAGAAAGTCTAGTTCATTG
CTACTGCCAAGAGCTAGTTCTTGTGTTCATATAGTAACTGCACAGGGCTTATAGCTGCTTCATTCTGCTACTTTGTAACTAGGAGCCATT
GCATTTATTAAATGTCCCTCAGTAACGTTAAGTGCTAGTTGTGATTTTATACATAAAGGCCAGAAGCTGTCTGAGGCAATCATGATTGAT
TGTATGTATCACTTACTGAAGAATACCTGAAGTGATCATGTAACTACTTATAAGGGATATCCATTTGTTTGATTACATGGGTAAATAATT
TGTCATTAAACTTGTGTTTGAATCATGAATTCCCTTGTTTCAAAAGACTTGCAGCTAATCTAAAAAACTGGTGATATTTAATATGCATGT
ATGTATCTAAACACCCACATATATTTGTGGTTTAAGTGTGAGAAATCTTGCTAATCTATATGCCACAGAAGAGCAAAATTGTATCCAAAT
TTATGCCACTTAAATTTCTTTACCACGAGGGATAGAGCATGCATACTGGTTTTTTTTTCTTGATTTGCCCATATAATTGGTAATGGATAA
CTTAATAAATTTGTGTGATATAAAAGTAGTGTATCATGTTCTACTGTTTGATCTTATCCCTTCCCATTTCTGCAAAGGTACTGTTAGCTG
GAAGAAAAACATTTTGGTTAGCTTTGTATGACAGTAGTCTTTCCCTTTATAGTTTCTCTATAAAAACTGGTTTTAAAATCAGTGGAAAAG
GGCAGGTTGAATCAAGGTGAATCAATCTGAAATTGAGCACACCTGCCTGCCATCGCTGTTCCTTCAACTGAGTGCTGCACATCATGGGCT
CTGTCTGTGAGAGAAAAATCCCGGTGCTTGGTGTCCTTGCATGACATGGAGTTTTGCATGTAGATCAATTTAAAATGTACCTCTTGTTTA
CATAATTTGCATAATTTTAAAAGATAATGTTGCCAAACTTTGGAAATGTTAATGTTCAGACTGAAAATCTCCACTACATGTAACTTTCTT
CCTCTGGATCAGTGGCATGGCTTATAATCCCAGCCAGTGGTTTGAACTGTTCCAGTGTCAACTGCCATGTGCTCTGCTTCAAGGGGGAAC
TAGCCTTTTGTGAATTTTTTGTACATAAGTATTTGTTACAAATATTTTAGCAAATGCTTTCTATTTCTCTTGCTTGTGCATATCTTGGCT
GGCGTTACAGAAAAATAGTGTAAACATTATTTCCTTACCGGGGAATGAGGGTTTTTTCTTTTTCTTTTTTTTTTTTTTTTTTTTTAGTTT
GTGTGTGGGGGTGGGTAAGGGAGGGGATGGTTTATGTTGAATGTTTAGTTTTTCTTCTGCATGATACGTCATGTTGTGGGATCTTTAGAA

>55702_55702_1_MTIF2-PPP3R1_MTIF2_chr2_55489452_ENST00000394600_PPP3R1_chr2_68415822_ENST00000234310_length(amino acids)=279AA_BP=123
MGLQACATTPRRNMNQKLLKLENLLRFHTIYRQLHSLCQRRALRQWRHGFSSAYPVWTAQLCAWPWPTDVLTGAALSQYRLLVTKKEEGP
WKSQLSSTKSKKVVEVWIGMTIEELARAMEKNTVDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVIDIFDTDGNGEVD
FKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLD

--------------------------------------------------------------
>55702_55702_2_MTIF2-PPP3R1_MTIF2_chr2_55489452_ENST00000394600_PPP3R1_chr2_68415822_ENST00000409377_length(transcript)=1554nt_BP=1068nt
CGGGGCTGTAGGTAGGAGTTAAGTGGGTAGGATCCCTTAACCAGGGTTGTCCGGTGCAGGTGGTGTGTGTTGTTTCGCCTAACGTGTCAG
TGGCACAAATCACGCGAACTTCATAAACATTGTGCGTTCGGAAGCCTTTCCAAGATGCATTTAATCCCTGCGTGAGCCCACGTTAGGCAT
TCACGAAGGCATGTGCACTGTTCTCTCGGAAGCGGCTGGCCGGCTTCCCCTCCTCGCGCGCGGCTGTGGGTGCAGGTCCTCACTTCCCAG
CCTCCCATGGGCCCAAGGCCTTCTGGGCTCCAATTTGAGGCGAGCCACCCCAGATCCGTAATTTTTCTGCAGTGATTTATTTTTACCTTT
CTGATTCCTTGACAAGGATATCCTAGCGGCGAAACAACACCGTACTGGGAGTCAGAACGTCTGGGTTCTAGTCTTGACTGCCATTAACTA
GCGGTATGACATTGGAGAAGCTTTTTTGACCCTTCTGGATTTCCGTTTCCTTTTCTGTAAAATGAGGAGCTTGGAAGATCCGGAAAATGA
GGCCCATAGGAAACAAGTGACTTGCTGAGTCCAGATAACACTGACTGTCAGAAGTCTCGCTCTGTCTCCCCGGCTGGAGTGCAGTGGCGT
GATCTTGGCTCACTGCAACCTCTGTCTCCCGGGTTCAAGAAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCA
CCACGCCCAGGAGAAACATGAACCAGAAGCTACTGAAGTTGGAGAACTTGCTACGATTTCACACTATTTATAGGCAACTGCACAGTCTGT
GTCAAAGAAGAGCATTAAGACAGTGGAGGCATGGGTTTTCATCTGCTTACCCTGTGTGGACAGCTCAACTGTGTGCCTGGCCCTGGCCAA
CAGATGTGCTCACTGGGGCTGCTTTATCTCAGTATAGGCTTCTAGTAACAAAAAAGGAAGAAGGACCATGGAAATCTCAGTTATCTTCAA
CAAAATCTAAAAAGGTGGTAGAAGTATGGATTGGAATGACTATTGAGGAACTGGCCAGGGCAATGGAAAAAAACACAGTTGATGCGGATG
AAATTAAAAGGCTAGGAAAGAGATTTAAGAAGCTTGATTTGGACAATTCTGGTTCTTTGAGTGTGGAAGAGTTCATGTCTCTGCCTGAGT
TACAACAGAATCCTTTAGTACAGCGAGTAATAGATATATTCGACACAGATGGGAATGGAGAAGTAGACTTTAAAGAATTCATTGAGGGCG
TCTCTCAGTTCAGTGTCAAAGGAGATAAGGAGCAGAAATTGAGGTTTGCTTTCCGTATCTATGACATGGATAAAGATGGCTATATTTCCA
ATGGGGAACTCTTCCAGGTATTGAAGATGATGGTGGGGAACAATCTGAAAGATACACAGTTACAGCAAATTGTAGACAAAACCATAATAA
ATGCAGATAAGGATGGAGATGGAAGAATATCCTTTGAAGAATTCTGTGCTGTTGTAGGTGGCCTAGATATCCACAAAAAGATGGTGGTAG

>55702_55702_2_MTIF2-PPP3R1_MTIF2_chr2_55489452_ENST00000394600_PPP3R1_chr2_68415822_ENST00000409377_length(amino acids)=279AA_BP=123
MGLQACATTPRRNMNQKLLKLENLLRFHTIYRQLHSLCQRRALRQWRHGFSSAYPVWTAQLCAWPWPTDVLTGAALSQYRLLVTKKEEGP
WKSQLSSTKSKKVVEVWIGMTIEELARAMEKNTVDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVIDIFDTDGNGEVD
FKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLD

--------------------------------------------------------------
>55702_55702_3_MTIF2-PPP3R1_MTIF2_chr2_55489452_ENST00000394600_PPP3R1_chr2_68415822_ENST00000409752_length(transcript)=1697nt_BP=1068nt
CGGGGCTGTAGGTAGGAGTTAAGTGGGTAGGATCCCTTAACCAGGGTTGTCCGGTGCAGGTGGTGTGTGTTGTTTCGCCTAACGTGTCAG
TGGCACAAATCACGCGAACTTCATAAACATTGTGCGTTCGGAAGCCTTTCCAAGATGCATTTAATCCCTGCGTGAGCCCACGTTAGGCAT
TCACGAAGGCATGTGCACTGTTCTCTCGGAAGCGGCTGGCCGGCTTCCCCTCCTCGCGCGCGGCTGTGGGTGCAGGTCCTCACTTCCCAG
CCTCCCATGGGCCCAAGGCCTTCTGGGCTCCAATTTGAGGCGAGCCACCCCAGATCCGTAATTTTTCTGCAGTGATTTATTTTTACCTTT
CTGATTCCTTGACAAGGATATCCTAGCGGCGAAACAACACCGTACTGGGAGTCAGAACGTCTGGGTTCTAGTCTTGACTGCCATTAACTA
GCGGTATGACATTGGAGAAGCTTTTTTGACCCTTCTGGATTTCCGTTTCCTTTTCTGTAAAATGAGGAGCTTGGAAGATCCGGAAAATGA
GGCCCATAGGAAACAAGTGACTTGCTGAGTCCAGATAACACTGACTGTCAGAAGTCTCGCTCTGTCTCCCCGGCTGGAGTGCAGTGGCGT
GATCTTGGCTCACTGCAACCTCTGTCTCCCGGGTTCAAGAAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCA
CCACGCCCAGGAGAAACATGAACCAGAAGCTACTGAAGTTGGAGAACTTGCTACGATTTCACACTATTTATAGGCAACTGCACAGTCTGT
GTCAAAGAAGAGCATTAAGACAGTGGAGGCATGGGTTTTCATCTGCTTACCCTGTGTGGACAGCTCAACTGTGTGCCTGGCCCTGGCCAA
CAGATGTGCTCACTGGGGCTGCTTTATCTCAGTATAGGCTTCTAGTAACAAAAAAGGAAGAAGGACCATGGAAATCTCAGTTATCTTCAA
CAAAATCTAAAAAGGTGGTAGAAGTATGGATTGGAATGACTATTGAGGAACTGGCCAGGGCAATGGAAAAAAACACAGTTGATGCGGATG
AAATTAAAAGGCTAGGAAAGAGATTTAAGAAGCTTGATTTGGACAATTCTGGTTCTTTGAGTGTGGAAGAGTTCATGTCTCTGCCTGAGT
TACAACAGAATCCTTTAGTACAGCGAGTAATAGATATATTCGACACAGATGGGAATGGAGAAGTAGACTTTAAAGAATTCATTGAGGGCG
TCTCTCAGTTCAGTGTCAAAGGAGATAAGGAGCAGAAATTGAGGTTTGCTTTCCGTATCTATGACATGGATAAAGATGGCTATATTTCCA
ATGGGGAACTCTTCCAGGTATTGAAGATGATGGTGGGGAACAATCTGAAAGATACACAGTTACAGCAAATTGTAGACAAAACCATAATAA
ATGCAGATAAGGATGGAGATGGAAGAATATCCTTTGAAGAATTCTGTGCTGTTGTAGGTGGCCTAGATATCCACAAAAAGATGGTGGTAG
ATGTGTGACTCTTATCAGAGAGTACCACCCAACACTTTTGCTTTCTTCTCCATCTCTGAAGATCTGCTCAAGACGTCCAGCAATGCTCTC

>55702_55702_3_MTIF2-PPP3R1_MTIF2_chr2_55489452_ENST00000394600_PPP3R1_chr2_68415822_ENST00000409752_length(amino acids)=279AA_BP=123
MGLQACATTPRRNMNQKLLKLENLLRFHTIYRQLHSLCQRRALRQWRHGFSSAYPVWTAQLCAWPWPTDVLTGAALSQYRLLVTKKEEGP
WKSQLSSTKSKKVVEVWIGMTIEELARAMEKNTVDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVIDIFDTDGNGEVD
FKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLD

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Fusion Gene PPI Analysis for MTIF2-PPP3R1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MTIF2-PPP3R1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MTIF2-PPP3R1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source