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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MTIF2-SMEK2 (FusionGDB2 ID:55705)

Fusion Gene Summary for MTIF2-SMEK2

Fusion gene summary

Fusion gene information	Fusion gene name: MTIF2-SMEK2
	Fusion gene ID: 55705
		Hgene	Tgene
	Gene symbol	MTIF2	SMEK2
	Gene ID	4528	57223
	Gene name	mitochondrial translational initiation factor 2	protein phosphatase 4 regulatory subunit 3B
	Synonyms	-	FLFL2\|PP4R3B\|PSY2\|SMEK2\|smk1
	Cytomap	2p16.1	2p16.1
	Type of gene	protein-coding	protein-coding
	Description	translation initiation factor IF-2, mitochondrialIF-2mt	serine/threonine-protein phosphatase 4 regulatory subunit 3BSMEK homolog 2, suppressor of mek1
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000263629, ENST00000394600, ENST00000403721, ENST00000446660,	ENST00000477749, ENST00000272313, ENST00000345102, ENST00000407823,
Fusion gene scores	* DoF score	6 X 8 X 4=192	2 X 1 X 1=2
	# samples	11	2
	** MAII score	log2(11/192*10)=-0.803602787196497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/2*10)=3.32192809488736
Context	PubMed: MTIF2 [Title/Abstract] AND SMEK2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MTIF2(55489452)-SMEK2(55842642), # samples:1
Anticipated loss of major functional domain due to fusion event.	MTIF2-SMEK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. MTIF2-SMEK2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MTIF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SMEK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-D7-6822-01A	MTIF2	chr2	55489452	-	SMEK2	chr2	55842642	-

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Fusion Gene ORF analysis for MTIF2-SMEK2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000263629	ENST00000477749	MTIF2	chr2	55489452	-	SMEK2	chr2	55842642	-
5CDS-5UTR	ENST00000394600	ENST00000477749	MTIF2	chr2	55489452	-	SMEK2	chr2	55842642	-
5CDS-5UTR	ENST00000403721	ENST00000477749	MTIF2	chr2	55489452	-	SMEK2	chr2	55842642	-
5UTR-3CDS	ENST00000446660	ENST00000272313	MTIF2	chr2	55489452	-	SMEK2	chr2	55842642	-
5UTR-3CDS	ENST00000446660	ENST00000345102	MTIF2	chr2	55489452	-	SMEK2	chr2	55842642	-
5UTR-3CDS	ENST00000446660	ENST00000407823	MTIF2	chr2	55489452	-	SMEK2	chr2	55842642	-
5UTR-5UTR	ENST00000446660	ENST00000477749	MTIF2	chr2	55489452	-	SMEK2	chr2	55842642	-
Frame-shift	ENST00000263629	ENST00000272313	MTIF2	chr2	55489452	-	SMEK2	chr2	55842642	-
Frame-shift	ENST00000263629	ENST00000345102	MTIF2	chr2	55489452	-	SMEK2	chr2	55842642	-
Frame-shift	ENST00000263629	ENST00000407823	MTIF2	chr2	55489452	-	SMEK2	chr2	55842642	-
Frame-shift	ENST00000403721	ENST00000272313	MTIF2	chr2	55489452	-	SMEK2	chr2	55842642	-
Frame-shift	ENST00000403721	ENST00000345102	MTIF2	chr2	55489452	-	SMEK2	chr2	55842642	-
Frame-shift	ENST00000403721	ENST00000407823	MTIF2	chr2	55489452	-	SMEK2	chr2	55842642	-
In-frame	ENST00000394600	ENST00000272313	MTIF2	chr2	55489452	-	SMEK2	chr2	55842642	-
In-frame	ENST00000394600	ENST00000345102	MTIF2	chr2	55489452	-	SMEK2	chr2	55842642	-
In-frame	ENST00000394600	ENST00000407823	MTIF2	chr2	55489452	-	SMEK2	chr2	55842642	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000394600	MTIF2	chr2	55489452	-	ENST00000272313	SMEK2	chr2	55842642	-	5840	1068	698	3220	840
ENST00000394600	MTIF2	chr2	55489452	-	ENST00000407823	SMEK2	chr2	55842642	-	4913	1068	698	3379	893
ENST00000394600	MTIF2	chr2	55489452	-	ENST00000345102	SMEK2	chr2	55842642	-	5008	1068	698	3475	925

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000394600	ENST00000272313	MTIF2	chr2	55489452	-	SMEK2	chr2	55842642	-	0.000254987	0.99974495
ENST00000394600	ENST00000407823	MTIF2	chr2	55489452	-	SMEK2	chr2	55842642	-	0.000231543	0.99976844
ENST00000394600	ENST00000345102	MTIF2	chr2	55489452	-	SMEK2	chr2	55842642	-	0.000181152	0.99981886

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Fusion Genomic Features for MTIF2-SMEK2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MTIF2-SMEK2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:55489452/chr2:55842642)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SMEK2

chr2:55489452

chr2:55842642

ENST00000272313

719_724

765.0

Compositional bias

Note=Poly-Glu

Tgene

SMEK2

chr2:55489452

chr2:55842642

ENST00000272313

831_838

765.0

Compositional bias

Note=Poly-Glu

Tgene

SMEK2

chr2:55489452

chr2:55842642

ENST00000345102

719_724

850.0

Compositional bias

Note=Poly-Glu

Tgene

SMEK2

chr2:55489452

chr2:55842642

ENST00000345102

831_838

850.0

Compositional bias

Note=Poly-Glu

Tgene

SMEK2

chr2:55489452

chr2:55842642

ENST00000407823

719_724

818.0

Compositional bias

Note=Poly-Glu

Tgene

SMEK2

chr2:55489452

chr2:55842642

ENST00000407823

831_838

818.0

Compositional bias

Note=Poly-Glu

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MTIF2

chr2:55489452

chr2:55842642

ENST00000263629

178_348

110

728.0

Domain

Note=tr-type G

Hgene

MTIF2

chr2:55489452

chr2:55842642

ENST00000394600

178_348

110

728.0

Domain

Note=tr-type G

Hgene

MTIF2

chr2:55489452

chr2:55842642

ENST00000403721

178_348

110

728.0

Domain

Note=tr-type G

Hgene

MTIF2

chr2:55489452

chr2:55842642

ENST00000263629

187_194

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:55842642

ENST00000263629

212_216

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:55842642

ENST00000263629

234_237

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:55842642

ENST00000263629

288_291

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:55842642

ENST00000263629

324_326

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:55842642

ENST00000394600

187_194

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:55842642

ENST00000394600

212_216

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:55842642

ENST00000394600

234_237

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:55842642

ENST00000394600

288_291

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:55842642

ENST00000394600

324_326

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:55842642

ENST00000403721

187_194

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:55842642

ENST00000403721

212_216

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:55842642

ENST00000403721

234_237

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:55842642

ENST00000403721

288_291

110

728.0

Region

Hgene

MTIF2

chr2:55489452

chr2:55842642

ENST00000403721

324_326

110

728.0

Region

Tgene

SMEK2

chr2:55489452

chr2:55842642

ENST00000272313

1_100

765.0

Domain

Note=WH1

Tgene

SMEK2

chr2:55489452

chr2:55842642

ENST00000345102

1_100

850.0

Domain

Note=WH1

Tgene

SMEK2

chr2:55489452

chr2:55842642

ENST00000407823

1_100

818.0

Domain

Note=WH1

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Fusion Gene Sequence for MTIF2-SMEK2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>55705_55705_1_MTIF2-SMEK2_MTIF2_chr2_55489452_ENST00000394600_SMEK2_chr2_55842642_ENST00000272313_length(transcript)=5840nt_BP=1068nt
CGGGGCTGTAGGTAGGAGTTAAGTGGGTAGGATCCCTTAACCAGGGTTGTCCGGTGCAGGTGGTGTGTGTTGTTTCGCCTAACGTGTCAG
TGGCACAAATCACGCGAACTTCATAAACATTGTGCGTTCGGAAGCCTTTCCAAGATGCATTTAATCCCTGCGTGAGCCCACGTTAGGCAT
TCACGAAGGCATGTGCACTGTTCTCTCGGAAGCGGCTGGCCGGCTTCCCCTCCTCGCGCGCGGCTGTGGGTGCAGGTCCTCACTTCCCAG
CCTCCCATGGGCCCAAGGCCTTCTGGGCTCCAATTTGAGGCGAGCCACCCCAGATCCGTAATTTTTCTGCAGTGATTTATTTTTACCTTT
CTGATTCCTTGACAAGGATATCCTAGCGGCGAAACAACACCGTACTGGGAGTCAGAACGTCTGGGTTCTAGTCTTGACTGCCATTAACTA
GCGGTATGACATTGGAGAAGCTTTTTTGACCCTTCTGGATTTCCGTTTCCTTTTCTGTAAAATGAGGAGCTTGGAAGATCCGGAAAATGA
GGCCCATAGGAAACAAGTGACTTGCTGAGTCCAGATAACACTGACTGTCAGAAGTCTCGCTCTGTCTCCCCGGCTGGAGTGCAGTGGCGT
GATCTTGGCTCACTGCAACCTCTGTCTCCCGGGTTCAAGAAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCA
CCACGCCCAGGAGAAACATGAACCAGAAGCTACTGAAGTTGGAGAACTTGCTACGATTTCACACTATTTATAGGCAACTGCACAGTCTGT
GTCAAAGAAGAGCATTAAGACAGTGGAGGCATGGGTTTTCATCTGCTTACCCTGTGTGGACAGCTCAACTGTGTGCCTGGCCCTGGCCAA
CAGATGTGCTCACTGGGGCTGCTTTATCTCAGTATAGGCTTCTAGTAACAAAAAAGGAAGAAGGACCATGGAAATCTCAGTTATCTTCAA
CAAAATCTAAAAAGGTGGTAGAAGTATGGATTGGAATGACTATTGAGGAACTGGCCAGGGCAATGGAAAAAAACACAGGATCACTACTCT
TGGAATCAAAGATAAATCCAAATACTGCATATCAGAAACAACAGGATACATTAATTGTTTGGTCAGAAGCAGAGAACTATGATTTGGCTC
TGAGTTTTCAGGAGAAAGCTGGCTGTGATGAGATCTGGGAAAAAATTTGTCAGGTTCAAGGTAAAGACCCATCAGTGGAAGTCACACAGG
ACCTCATTGATGAATCTGAAGAAGAACGATTTGAAGAAATGCCTGAAACTAGTCATCTGATTGACCTGCCCACATGTGAACTCAATAAAC
TTGAAGAGATTGCTGACTTAGTTACCTCAGTGCTCTCCTCACCTATCCGTAGGGAAAAGCTGGCTCTCGCCTTGGAAAATGAAGGCTATA
TTAAAAAACTATTGCAGCTGTTCCAAGCTTGCGAGAACCTAGAAAACACTGAAGGCTTACACCATTTGTATGAAATTATTAGAGGAATCT
TATTCCTAAATAAGGCAACTCTTTTTGAGGTAATGTTTTCTGATGAGTGTATCATGGATGTCGTGGGATGCCTTGAATATGACCCTGCTT
TGGCTCAGCCAAAAAGACATAGAGAATTCTTGACCAAAACTGCAAAGTTCAAGGAAGTTATACCAATAACAGACTCTGAACTAAGGCAAA
AAATACATCAGACTTACAGGGTACAGTACATTCAGGACATCATTTTGCCCACACCATCTGTTTTTGAAGAGAATTTTCTTTCTACTCTTA
CGTCTTTTATTTTCTTCAACAAAGTTGAGATAGTCAGCATGTTGCAGGAAGATGAGAAGTTTTTGTCTGAAGTTTTTGCACAATTAACAG
ATGAGGCTACAGATGATGATAAACGGCGTGAATTGGTTAATTTTTTCAAGGAGTTTTGTGCATTTTCTCAGACATTACAACCTCAAAACA
GGGATGCATTTTTCAAAACATTGGCAAAATTGGGAATTCTTCCTGCTCTTGAAATTGTAATGGGCATGGATGATTTGCAAGTCAGATCAG
CTGCTACAGATATATTTTCTTATCTAGTAGAATTTAGTCCATCTATGGTCCGAGAGTTTGTAATGCAAGAAGCTCAGCAGAGTGATGACG
ATATTCTTCTTATTAATGTGGTAATTGAACAAATGATCTGTGATACTGATCCTGAGCTAGGAGGCGCTGTTCAGTTAATGGGACTTCTTC
GTACTCTAATTGATCCAGAGAACATGCTGGCTACAACTAATAAAACCGAAAAAAGTGAATTTCTAAATTTTTTCTACAACCATTGTATGC
ATGTTCTCACAGCACCACTTTTGACCAATACTTCAGAAGACAAATGTGAAAAGGATAATATAGTTGGATCAAACAAAAACAACACAATTT
GTCCCGGTGCCCTTCGCTTTATGAGGCGGATAATTGGACTTAAAGATGAATTTTATAATCGTTACATCACCAAGGGAAATCTTTTTGAGC
CAGTTATAAATGCACTTCTGGATAATGGAACTCGGTATAATCTGTTGAATTCAGCTGTTATTGAGTTGTTTGAATTTATAAGAGTGGAAG
ATATCAAGTCTCTTACTGCCCATATAGTTGAAAACTTTTATAAAGCACTTGAATCGATTGAATATGTTCAGACATTCAAAGGATTGAAGA
CTAAATATGAGCAAGAAAAAGACAGACAAAATCAGAAACTGAACAGTGTACCATCTATATTGCGTAGTAACAGATTTCGCAGAGATGCAA
AAGCCTTGGAAGAGGATGAAGAAATGTGGTTTAATGAAGATGAAGAAGAGGAAGGAAAAGCAGTTGTGGCACCAGTGGAAAAACCTAAGC
CAGAAGATGATTTTCCAGATAATTATGAAAAGTTTATGGAGACTAAAAAAGCAAAAGAAAGTGAAGACAAGGAAAACCTTCCCAAAAGGA
CATCTCCTGGTGGCTTCAAATTTACTTTCTCCCACTCTGCCAGTGCTGCTAATGGAACAAACAGTAAATCTGTAGTGGCTCAGATACCAC
CAGCAACTTCTAATGGATCCTCTTCCAAAACCACAAACTTGCCTACGTCAGTAACAGCCACCAAGGGAAGTTTGGTTGGCTTAGTGGATT
ATCCAGATGATGAAGAGGAAGATGAAGAAGAAGAATCGTCCCCCAGGAAAAGACCTCGTCTTGGCTCATAAAATATTTATTAGGGGACCC
TCAACATGTGGTCTTACAATGCTGCAACTGTTCAGTGAGCTGAAAATCTGAATCAGAAAGCTTTCTCAATTGAACTTATAAAATATACAA
GGAGTAGCAAAAGACAGTATATCAGCTAAGAGAGTTTAGTTCTAATAAAAATCAGGCTTCCCAGGAACTTGATTGCTTGCTAGTAATTAA
GGGGTTTGCCTTTTAGGCTGTCAAAACAAACATTAGTAACCAGAACCTGGGAGACAGCTTCTCAGCAAGGAAAAGTCACAGGTTTGGGGA
CGGTTTAGGGGAGGGGAAAAGGTTGATATAATAATGCAGGGTTGCTCCTCGGGGTGTCGATCTAGAAACAATTTTACAGAACTTCAGTTG
TAAACTCAATAACATTACTTGTATAATGGTGCTGGCCATGTTGTTGTTTTAATCAGTTGCCTCTTTTTAAAAGAAATTTTTATGGAAAAC
ACATTCAACTATCATTAAAAAAATGAAGTTAAGCTGTTGGGACCATTTCTTTAAGATTTAACAAAAGTTCAGCCTTTTAGGTAGTTGAAG
GGAAGTACACCCCGTATTCAGCACATGTTGAGTTTTCTACACCAGGAATTTTCAATATGTATATTGATGAAAACAAGCTCAATTCAAACT
GGACAGTTTTAAGATAATGTTAAAATCAGCACTTTTAGAGACAACGAAGGCCAAGAATCAGTACAGTAGTATTCCAAAATGATTTTCTCT
AGAAATTTGAAAGTAGATCGAACAGAATGTTGTCAACCGCCTACCAGTACAATCTTTTGTGGAAGATACTTTGAAATCACTTTCTACTTT
GTTAGTAAAGTTCTGTCTTTCCAGAGCTGCAAGTTTTAAAGTGTTACTTATACAGACCAACCAAGAATAGTGCTGAATTAAGTGGCATTT
AGTATCTAGAAGCCATTTTGATCCAAGAAGCTACTTAAGTGTCAAAGTCAGCATGCAGCACATGTAGCTTTTCTGTAAACAAGGGTGTGA
TATGAAAGCTGCTTTTTTAAGAAGAGTAAAAGCACATTCCATATACGTAAGTGAATTTTAAAAATAAATTGAGGCAAACAGTTAAGTTTT
ATTTTTAGAGCAACAAGTTAACTGTAAATATTTTAATGTTAGTTTGCTCATCTATGATCTGAGATCATGCCGAAGTGAGAAAAATCTCCC
CAAAATACAATTTAATGCATTGGGAAAAAAAAACTTTAACAGTAATTCCAGCCACAATCTTTAGATCACCCTTGTAATGTGTTACGGGTC
CATTTTTCCTGGAATCGTTTAATCTAAAGCAGTTTCCCCTGTTTTGGAGATTTTGTAGTTAATTTTAATTTTGGCTATTGTTTGGAAAAG
ATGAGCTGTCTGTGTAGATATGAAGTATAGTTTTTTCCATAAAACAGATGTTTATTTTGTATTAAAAAATACCACTGTACTTGTTTTACA
CCATTTGTATACATGTGGTGATATTAATGCTAAACTGTAAAATTCAGGAATTAAAATGTGACCCTGTAATTCCATAATTGATGTTTGTGT
TTGGTTTGTTGTAAATATAAATTAACTCCATTTTGAGATATGTCAATTTTACAGTATCTTTTAAAAGCCAATAAAATTATCCATAAATAT
TTATTATAAACTGCTAGATCATACCCCAATTTTAATGAAATAATTCTAAACAAATGCGGGTCAATGGCACTTTATCAGTGACTACTTATA
GAAGGTAAGCCTTGGGGAAATCATAGCATCACAGTATGGAGCTTTTCTCACCTTTTCAATTAAAGGTGTACATATAGTAAGAAAGAAAGA
CCTTCCACCTCATAAGGCAGGTGACTCAGGATATTTTAAACTAAGATCAGTAAAGTTCCCATCCACTTTCTTTGAATCATCAAATTTTAT
CGAGACCCATCTCTCAGCTTTTAGTAAATTTCTTCTTAAAATAAGCCCACATGTAAAACACTTTCCTAGTTACTTTTTGTTTGTTTGTTT
GAGTCTCGCTCTGTTGCCCAGGCTGGAGTGTAGTTGCACGATTTCGGCTTATTGCAACATCCGCCACCTGGGTTCAAGCAATTCTCTGCC
TCAGCCTGAGTAGCTGGGATTACAGGTGCCCGTCACCATGCCAGGCTAATTTTTGTATTTTCAGTAGAGACGGGGTTTCACCATCTTGGC
CAGGCTGGTCTTAAACTCCTGACCTCACAATCCACCCGCCTCAGCCTCCCTATCTCTGTATCTTATGAAGACTTCCTTTTTCTTTCTGAA
GAGCTGCCATAAGTCTTAAACATTTAAATCATCAGAACCTTTTCTTGTAGCAGAAATGTGAATGTTTTCTTGAAGTACAGGTTACGGTTT
TCATGGTACAAGTGCTTACCTACGACGATAAGAGAACAAGGCTTAAAATATCCCTCAAAAGAACAATTGTGAGAATTCCATGTTAGCGGC
TGTCTTTAAACGACTACCCTCAGGCAGATCTGGGTTTTTATATCTTTATCTTCATTCAGTGAAGCAAGCCAAAAGCCCACATTTGTATGC

>55705_55705_1_MTIF2-SMEK2_MTIF2_chr2_55489452_ENST00000394600_SMEK2_chr2_55842642_ENST00000272313_length(amino acids)=840AA_BP=123
MGLQACATTPRRNMNQKLLKLENLLRFHTIYRQLHSLCQRRALRQWRHGFSSAYPVWTAQLCAWPWPTDVLTGAALSQYRLLVTKKEEGP
WKSQLSSTKSKKVVEVWIGMTIEELARAMEKNTGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKD
PSVEVTQDLIDESEEERFEEMPETSHLIDLPTCELNKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQACENLENTEGLHHL
YEIIRGILFLNKATLFEVMFSDECIMDVVGCLEYDPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQYIQDIILPTPSVFE
ENFLSTLTSFIFFNKVEIVSMLQEDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLAKLGILPALEIVMGM
DDLQVRSAATDIFSYLVEFSPSMVREFVMQEAQQSDDDILLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENMLATTNKTEKSEFLN
FFYNHCMHVLTAPLLTNTSEDKCEKDNIVGSNKNNTICPGALRFMRRIIGLKDEFYNRYITKGNLFEPVINALLDNGTRYNLLNSAVIEL
FEFIRVEDIKSLTAHIVENFYKALESIEYVQTFKGLKTKYEQEKDRQNQKLNSVPSILRSNRFRRDAKALEEDEEMWFNEDEEEEGKAVV
APVEKPKPEDDFPDNYEKFMETKKAKESEDKENLPKRTSPGGFKFTFSHSASAANGTNSKSVVAQIPPATSNGSSSKTTNLPTSVTATKG

--------------------------------------------------------------
>55705_55705_2_MTIF2-SMEK2_MTIF2_chr2_55489452_ENST00000394600_SMEK2_chr2_55842642_ENST00000345102_length(transcript)=5008nt_BP=1068nt
CGGGGCTGTAGGTAGGAGTTAAGTGGGTAGGATCCCTTAACCAGGGTTGTCCGGTGCAGGTGGTGTGTGTTGTTTCGCCTAACGTGTCAG
TGGCACAAATCACGCGAACTTCATAAACATTGTGCGTTCGGAAGCCTTTCCAAGATGCATTTAATCCCTGCGTGAGCCCACGTTAGGCAT
TCACGAAGGCATGTGCACTGTTCTCTCGGAAGCGGCTGGCCGGCTTCCCCTCCTCGCGCGCGGCTGTGGGTGCAGGTCCTCACTTCCCAG
CCTCCCATGGGCCCAAGGCCTTCTGGGCTCCAATTTGAGGCGAGCCACCCCAGATCCGTAATTTTTCTGCAGTGATTTATTTTTACCTTT
CTGATTCCTTGACAAGGATATCCTAGCGGCGAAACAACACCGTACTGGGAGTCAGAACGTCTGGGTTCTAGTCTTGACTGCCATTAACTA
GCGGTATGACATTGGAGAAGCTTTTTTGACCCTTCTGGATTTCCGTTTCCTTTTCTGTAAAATGAGGAGCTTGGAAGATCCGGAAAATGA
GGCCCATAGGAAACAAGTGACTTGCTGAGTCCAGATAACACTGACTGTCAGAAGTCTCGCTCTGTCTCCCCGGCTGGAGTGCAGTGGCGT
GATCTTGGCTCACTGCAACCTCTGTCTCCCGGGTTCAAGAAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCA
CCACGCCCAGGAGAAACATGAACCAGAAGCTACTGAAGTTGGAGAACTTGCTACGATTTCACACTATTTATAGGCAACTGCACAGTCTGT
GTCAAAGAAGAGCATTAAGACAGTGGAGGCATGGGTTTTCATCTGCTTACCCTGTGTGGACAGCTCAACTGTGTGCCTGGCCCTGGCCAA
CAGATGTGCTCACTGGGGCTGCTTTATCTCAGTATAGGCTTCTAGTAACAAAAAAGGAAGAAGGACCATGGAAATCTCAGTTATCTTCAA
CAAAATCTAAAAAGGTGGTAGAAGTATGGATTGGAATGACTATTGAGGAACTGGCCAGGGCAATGGAAAAAAACACAGGATCACTACTCT
TGGAATCAAAGATAAATCCAAATACTGCATATCAGAAACAACAGGATACATTAATTGTTTGGTCAGAAGCAGAGAACTATGATTTGGCTC
TGAGTTTTCAGGAGAAAGCTGGCTGTGATGAGATCTGGGAAAAAATTTGTCAGGTTCAAGGTAAAGACCCATCAGTGGAAGTCACACAGG
ACCTCATTGATGAATCTGAAGAAGAACGATTTGAAGAAATGCCTGAAACTAGTCATCTGATTGACCTGCCCACATGTGAACTCAATAAAC
TTGAAGAGATTGCTGACTTAGTTACCTCAGTGCTCTCCTCACCTATCCGTAGGGAAAAGCTGGCTCTCGCCTTGGAAAATGAAGGCTATA
TTAAAAAACTATTGCAGCTGTTCCAAGCTTGCGAGAACCTAGAAAACACTGAAGGCTTACACCATTTGTATGAAATTATTAGAGGAATCT
TATTCCTAAATAAGGCAACTCTTTTTGAGGTAATGTTTTCTGATGAGTGTATCATGGATGTCGTGGGATGCCTTGAATATGACCCTGCTT
TGGCTCAGCCAAAAAGACATAGAGAATTCTTGACCAAAACTGCAAAGTTCAAGGAAGTTATACCAATAACAGACTCTGAACTAAGGCAAA
AAATACATCAGACTTACAGGGTACAGTACATTCAGGACATCATTTTGCCCACACCATCTGTTTTTGAAGAGAATTTTCTTTCTACTCTTA
CGTCTTTTATTTTCTTCAACAAAGTTGAGATAGTCAGCATGTTGCAGGAAGATGAGAAGTTTTTGTCTGAAGTTTTTGCACAATTAACAG
ATGAGGCTACAGATGATGATAAACGGCGTGAATTGGTTAATTTTTTCAAGGAGTTTTGTGCATTTTCTCAGACATTACAACCTCAAAACA
GGGATGCATTTTTCAAAACATTGGCAAAATTGGGAATTCTTCCTGCTCTTGAAATTGTAATGGGCATGGATGATTTGCAAGTCAGATCAG
CTGCTACAGATATATTTTCTTATCTAGTAGAATTTAGTCCATCTATGGTCCGAGAGTTTGTAATGCAAGAAGCTCAGCAGAGTGATGACG
ATATTCTTCTTATTAATGTGGTAATTGAACAAATGATCTGTGATACTGATCCTGAGCTAGGAGGCGCTGTTCAGTTAATGGGACTTCTTC
GTACTCTAATTGATCCAGAGAACATGCTGGCTACAACTAATAAAACCGAAAAAAGTGAATTTCTAAATTTTTTCTACAACCATTGTATGC
ATGTTCTCACAGCACCACTTTTGACCAATACTTCAGAAGACAAATGTGAAAAGGATTTTTTTTTAAAACATTACAGATATAGTTGGAGTT
TCATATGTACCCCTTCACATTCCCATTCCCATTCTACCCCCTCTTCCTCCATCTCTCAAGATAATATAGTTGGATCAAACAAAAACAACA
CAATTTGTCCCGATAATTATCAAACAGCACAGCTACTTGCCTTAATTTTAGAGTTACTCACATTTTGTGTGGAACATCACACATATCACA
TAAAAAACTATATTATGAACAAGGACTTGCTAAGAAGAGTCTTGGTCTTGATGAATTCAAAGCACACTTTTCTGGCCTTGTGTGCCCTTC
GCTTTATGAGGCGGATAATTGGACTTAAAGATGAATTTTATAATCGTTACATCACCAAGGGAAATCTTTTTGAGCCAGTTATAAATGCAC
TTCTGGATAATGGAACTCGGTATAATCTGTTGAATTCAGCTGTTATTGAGTTGTTTGAATTTATAAGAGTGGAAGATATCAAGTCTCTTA
CTGCCCATATAGTTGAAAACTTTTATAAAGCACTTGAATCGATTGAATATGTTCAGACATTCAAAGGATTGAAGACTAAATATGAGCAAG
AAAAAGACAGACAAAATCAGAAACTGAACAGTGTACCATCTATATTGCGTAGTAACAGATTTCGCAGAGATGCAAAAGCCTTGGAAGAGG
ATGAAGAAATGTGGTTTAATGAAGATGAAGAAGAGGAAGGAAAAGCAGTTGTGGCACCAGTGGAAAAACCTAAGCCAGAAGATGATTTTC
CAGATAATTATGAAAAGTTTATGGAGACTAAAAAAGCAAAAGAAAGTGAAGACAAGGAAAACCTTCCCAAAAGGACATCTCCTGGTGGCT
TCAAATTTACTTTCTCCCACTCTGCCAGTGCTGCTAATGGAACAAACAGTAAATCTGTAGTGGCTCAGATACCACCAGCAACTTCTAATG
GATCCTCTTCCAAAACCACAAACTTGCCTACGTCAGTAACAGCCACCAAGGGAAGTTTGGTTGGCTTAGTGGATTATCCAGATGATGAAG
AGGAAGATGAAGAAGAAGAATCGTCCCCCAGGAAAAGACCTCGTCTTGGCTCATAAAATATTTATTAGGGGACCCTCAACATGTGGTCTT
ACAATGCTGCAACTGTTCAGTGAGCTGAAAATCTGAATCAGAAAGCTTTCTCAATTGAACTTATAAAATATACAAGGAGTAGCAAAAGAC
AGTATATCAGCTAAGAGAGTTTAGTTCTAATAAAAATCAGGCTTCCCAGGAACTTGATTGCTTGCTAGTAATTAAGGGGTTTGCCTTTTA
GGCTGTCAAAACAAACATTAGTAACCAGAACCTGGGAGACAGCTTCTCAGCAAGGAAAAGTCACAGGTTTGGGGACGGTTTAGGGGAGGG
GAAAAGGTTGATATAATAATGCAGGGTTGCTCCTCGGGGTGTCGATCTAGAAACAATTTTACAGAACTTCAGTTGTAAACTCAATAACAT
TACTTGTATAATGGTGCTGGCCATGTTGTTGTTTTAATCAGTTGCCTCTTTTTAAAAGAAATTTTTATGGAAAACACATTCAACTATCAT
TAAAAAAATGAAGTTAAGCTGTTGGGACCATTTCTTTAAGATTTAACAAAAGTTCAGCCTTTTAGGTAGTTGAAGGGAAGTACACCCCGT
ATTCAGCACATGTTGAGTTTTCTACACCAGGAATTTTCAATATGTATATTGATGAAAACAAGCTCAATTCAAACTGGACAGTTTTAAGAT
AATGTTAAAATCAGCACTTTTAGAGACAACGAAGGCCAAGAATCAGTACAGTAGTATTCCAAAATGATTTTCTCTAGAAATTTGAAAGTA
GATCGAACAGAATGTTGTCAACCGCCTACCAGTACAATCTTTTGTGGAAGATACTTTGAAATCACTTTCTACTTTGTTAGTAAAGTTCTG
TCTTTCCAGAGCTGCAAGTTTTAAAGTGTTACTTATACAGACCAACCAAGAATAGTGCTGAATTAAGTGGCATTTAGTATCTAGAAGCCA
TTTTGATCCAAGAAGCTACTTAAGTGTCAAAGTCAGCATGCAGCACATGTAGCTTTTCTGTAAACAAGGGTGTGATATGAAAGCTGCTTT
TTTAAGAAGAGTAAAAGCACATTCCATATACGTAAGTGAATTTTAAAAATAAATTGAGGCAAACAGTTAAGTTTTATTTTTAGAGCAACA
AGTTAACTGTAAATATTTTAATGTTAGTTTGCTCATCTATGATCTGAGATCATGCCGAAGTGAGAAAAATCTCCCCAAAATACAATTTAA
TGCATTGGGAAAAAAAAACTTTAACAGTAATTCCAGCCACAATCTTTAGATCACCCTTGTAATGTGTTACGGGTCCATTTTTCCTGGAAT
CGTTTAATCTAAAGCAGTTTCCCCTGTTTTGGAGATTTTGTAGTTAATTTTAATTTTGGCTATTGTTTGGAAAAGATGAGCTGTCTGTGT
AGATATGAAGTATAGTTTTTTCCATAAAACAGATGTTTATTTTGTATTAAAAAATACCACTGTACTTGTTTTACACCATTTGTATACATG

>55705_55705_2_MTIF2-SMEK2_MTIF2_chr2_55489452_ENST00000394600_SMEK2_chr2_55842642_ENST00000345102_length(amino acids)=925AA_BP=123
MGLQACATTPRRNMNQKLLKLENLLRFHTIYRQLHSLCQRRALRQWRHGFSSAYPVWTAQLCAWPWPTDVLTGAALSQYRLLVTKKEEGP
WKSQLSSTKSKKVVEVWIGMTIEELARAMEKNTGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKD
PSVEVTQDLIDESEEERFEEMPETSHLIDLPTCELNKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQACENLENTEGLHHL
YEIIRGILFLNKATLFEVMFSDECIMDVVGCLEYDPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQYIQDIILPTPSVFE
ENFLSTLTSFIFFNKVEIVSMLQEDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLAKLGILPALEIVMGM
DDLQVRSAATDIFSYLVEFSPSMVREFVMQEAQQSDDDILLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENMLATTNKTEKSEFLN
FFYNHCMHVLTAPLLTNTSEDKCEKDFFLKHYRYSWSFICTPSHSHSHSTPSSSISQDNIVGSNKNNTICPDNYQTAQLLALILELLTFC
VEHHTYHIKNYIMNKDLLRRVLVLMNSKHTFLALCALRFMRRIIGLKDEFYNRYITKGNLFEPVINALLDNGTRYNLLNSAVIELFEFIR
VEDIKSLTAHIVENFYKALESIEYVQTFKGLKTKYEQEKDRQNQKLNSVPSILRSNRFRRDAKALEEDEEMWFNEDEEEEGKAVVAPVEK
PKPEDDFPDNYEKFMETKKAKESEDKENLPKRTSPGGFKFTFSHSASAANGTNSKSVVAQIPPATSNGSSSKTTNLPTSVTATKGSLVGL

--------------------------------------------------------------
>55705_55705_3_MTIF2-SMEK2_MTIF2_chr2_55489452_ENST00000394600_SMEK2_chr2_55842642_ENST00000407823_length(transcript)=4913nt_BP=1068nt
CGGGGCTGTAGGTAGGAGTTAAGTGGGTAGGATCCCTTAACCAGGGTTGTCCGGTGCAGGTGGTGTGTGTTGTTTCGCCTAACGTGTCAG
TGGCACAAATCACGCGAACTTCATAAACATTGTGCGTTCGGAAGCCTTTCCAAGATGCATTTAATCCCTGCGTGAGCCCACGTTAGGCAT
TCACGAAGGCATGTGCACTGTTCTCTCGGAAGCGGCTGGCCGGCTTCCCCTCCTCGCGCGCGGCTGTGGGTGCAGGTCCTCACTTCCCAG
CCTCCCATGGGCCCAAGGCCTTCTGGGCTCCAATTTGAGGCGAGCCACCCCAGATCCGTAATTTTTCTGCAGTGATTTATTTTTACCTTT
CTGATTCCTTGACAAGGATATCCTAGCGGCGAAACAACACCGTACTGGGAGTCAGAACGTCTGGGTTCTAGTCTTGACTGCCATTAACTA
GCGGTATGACATTGGAGAAGCTTTTTTGACCCTTCTGGATTTCCGTTTCCTTTTCTGTAAAATGAGGAGCTTGGAAGATCCGGAAAATGA
GGCCCATAGGAAACAAGTGACTTGCTGAGTCCAGATAACACTGACTGTCAGAAGTCTCGCTCTGTCTCCCCGGCTGGAGTGCAGTGGCGT
GATCTTGGCTCACTGCAACCTCTGTCTCCCGGGTTCAAGAAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCA
CCACGCCCAGGAGAAACATGAACCAGAAGCTACTGAAGTTGGAGAACTTGCTACGATTTCACACTATTTATAGGCAACTGCACAGTCTGT
GTCAAAGAAGAGCATTAAGACAGTGGAGGCATGGGTTTTCATCTGCTTACCCTGTGTGGACAGCTCAACTGTGTGCCTGGCCCTGGCCAA
CAGATGTGCTCACTGGGGCTGCTTTATCTCAGTATAGGCTTCTAGTAACAAAAAAGGAAGAAGGACCATGGAAATCTCAGTTATCTTCAA
CAAAATCTAAAAAGGTGGTAGAAGTATGGATTGGAATGACTATTGAGGAACTGGCCAGGGCAATGGAAAAAAACACAGGATCACTACTCT
TGGAATCAAAGATAAATCCAAATACTGCATATCAGAAACAACAGGATACATTAATTGTTTGGTCAGAAGCAGAGAACTATGATTTGGCTC
TGAGTTTTCAGGAGAAAGCTGGCTGTGATGAGATCTGGGAAAAAATTTGTCAGGTTCAAGGTAAAGACCCATCAGTGGAAGTCACACAGG
ACCTCATTGATGAATCTGAAGAAGAACGATTTGAAGAAATGCCTGAAACTAGTCATCTGATTGACCTGCCCACATGTGAACTCAATAAAC
TTGAAGAGATTGCTGACTTAGTTACCTCAGTGCTCTCCTCACCTATCCGTAGGGAAAAGCTGGCTCTCGCCTTGGAAAATGAAGGCTATA
TTAAAAAACTATTGCAGCTGTTCCAAGCTTGCGAGAACCTAGAAAACACTGAAGGCTTACACCATTTGTATGAAATTATTAGAGGAATCT
TATTCCTAAATAAGGCAACTCTTTTTGAGGTAATGTTTTCTGATGAGTGTATCATGGATGTCGTGGGATGCCTTGAATATGACCCTGCTT
TGGCTCAGCCAAAAAGACATAGAGAATTCTTGACCAAAACTGCAAAGTTCAAGGAAGTTATACCAATAACAGACTCTGAACTAAGGCAAA
AAATACATCAGACTTACAGGGTACAGTACATTCAGGACATCATTTTGCCCACACCATCTGTTTTTGAAGAGAATTTTCTTTCTACTCTTA
CGTCTTTTATTTTCTTCAACAAAGTTGAGATAGTCAGCATGTTGCAGGAAGATGAGAAGTTTTTGTCTGAAGTTTTTGCACAATTAACAG
ATGAGGCTACAGATGATGATAAACGGCGTGAATTGGTTAATTTTTTCAAGGAGTTTTGTGCATTTTCTCAGACATTACAACCTCAAAACA
GGGATGCATTTTTCAAAACATTGGCAAAATTGGGAATTCTTCCTGCTCTTGAAATTGTAATGGGCATGGATGATTTGCAAGTCAGATCAG
CTGCTACAGATATATTTTCTTATCTAGTAGAATTTAGTCCATCTATGGTCCGAGAGTTTGTAATGCAAGAAGCTCAGCAGAGTGATGACG
ATATTCTTCTTATTAATGTGGTAATTGAACAAATGATCTGTGATACTGATCCTGAGCTAGGAGGCGCTGTTCAGTTAATGGGACTTCTTC
GTACTCTAATTGATCCAGAGAACATGCTGGCTACAACTAATAAAACCGAAAAAAGTGAATTTCTAAATTTTTTCTACAACCATTGTATGC
ATGTTCTCACAGCACCACTTTTGACCAATACTTCAGAAGACAAATGTGAAAAGGATAATATAGTTGGATCAAACAAAAACAACACAATTT
GTCCCGATAATTATCAAACAGCACAGCTACTTGCCTTAATTTTAGAGTTACTCACATTTTGTGTGGAACATCACACATATCACATAAAAA
ACTATATTATGAACAAGGACTTGCTAAGAAGAGTCTTGGTCTTGATGAATTCAAAGCACACTTTTCTGGCCTTGTGTGCCCTTCGCTTTA
TGAGGCGGATAATTGGACTTAAAGATGAATTTTATAATCGTTACATCACCAAGGGAAATCTTTTTGAGCCAGTTATAAATGCACTTCTGG
ATAATGGAACTCGGTATAATCTGTTGAATTCAGCTGTTATTGAGTTGTTTGAATTTATAAGAGTGGAAGATATCAAGTCTCTTACTGCCC
ATATAGTTGAAAACTTTTATAAAGCACTTGAATCGATTGAATATGTTCAGACATTCAAAGGATTGAAGACTAAATATGAGCAAGAAAAAG
ACAGACAAAATCAGAAACTGAACAGTGTACCATCTATATTGCGTAGTAACAGATTTCGCAGAGATGCAAAAGCCTTGGAAGAGGATGAAG
AAATGTGGTTTAATGAAGATGAAGAAGAGGAAGGAAAAGCAGTTGTGGCACCAGTGGAAAAACCTAAGCCAGAAGATGATTTTCCAGATA
ATTATGAAAAGTTTATGGAGACTAAAAAAGCAAAAGAAAGTGAAGACAAGGAAAACCTTCCCAAAAGGACATCTCCTGGTGGCTTCAAAT
TTACTTTCTCCCACTCTGCCAGTGCTGCTAATGGAACAAACAGTAAATCTGTAGTGGCTCAGATACCACCAGCAACTTCTAATGGATCCT
CTTCCAAAACCACAAACTTGCCTACGTCAGTAACAGCCACCAAGGGAAGTTTGGTTGGCTTAGTGGATTATCCAGATGATGAAGAGGAAG
ATGAAGAAGAAGAATCGTCCCCCAGGAAAAGACCTCGTCTTGGCTCATAAAATATTTATTAGGGGACCCTCAACATGTGGTCTTACAATG
CTGCAACTGTTCAGTGAGCTGAAAATCTGAATCAGAAAGCTTTCTCAATTGAACTTATAAAATATACAAGGAGTAGCAAAAGACAGTATA
TCAGCTAAGAGAGTTTAGTTCTAATAAAAATCAGGCTTCCCAGGAACTTGATTGCTTGCTAGTAATTAAGGGGTTTGCCTTTTAGGCTGT
CAAAACAAACATTAGTAACCAGAACCTGGGAGACAGCTTCTCAGCAAGGAAAAGTCACAGGTTTGGGGACGGTTTAGGGGAGGGGAAAAG
GTTGATATAATAATGCAGGGTTGCTCCTCGGGGTGTCGATCTAGAAACAATTTTACAGAACTTCAGTTGTAAACTCAATAACATTACTTG
TATAATGGTGCTGGCCATGTTGTTGTTTTAATCAGTTGCCTCTTTTTAAAAGAAATTTTTATGGAAAACACATTCAACTATCATTAAAAA
AATGAAGTTAAGCTGTTGGGACCATTTCTTTAAGATTTAACAAAAGTTCAGCCTTTTAGGTAGTTGAAGGGAAGTACACCCCGTATTCAG
CACATGTTGAGTTTTCTACACCAGGAATTTTCAATATGTATATTGATGAAAACAAGCTCAATTCAAACTGGACAGTTTTAAGATAATGTT
AAAATCAGCACTTTTAGAGACAACGAAGGCCAAGAATCAGTACAGTAGTATTCCAAAATGATTTTCTCTAGAAATTTGAAAGTAGATCGA
ACAGAATGTTGTCAACCGCCTACCAGTACAATCTTTTGTGGAAGATACTTTGAAATCACTTTCTACTTTGTTAGTAAAGTTCTGTCTTTC
CAGAGCTGCAAGTTTTAAAGTGTTACTTATACAGACCAACCAAGAATAGTGCTGAATTAAGTGGCATTTAGTATCTAGAAGCCATTTTGA
TCCAAGAAGCTACTTAAGTGTCAAAGTCAGCATGCAGCACATGTAGCTTTTCTGTAAACAAGGGTGTGATATGAAAGCTGCTTTTTTAAG
AAGAGTAAAAGCACATTCCATATACGTAAGTGAATTTTAAAAATAAATTGAGGCAAACAGTTAAGTTTTATTTTTAGAGCAACAAGTTAA
CTGTAAATATTTTAATGTTAGTTTGCTCATCTATGATCTGAGATCATGCCGAAGTGAGAAAAATCTCCCCAAAATACAATTTAATGCATT
GGGAAAAAAAAACTTTAACAGTAATTCCAGCCACAATCTTTAGATCACCCTTGTAATGTGTTACGGGTCCATTTTTCCTGGAATCGTTTA
ATCTAAAGCAGTTTCCCCTGTTTTGGAGATTTTGTAGTTAATTTTAATTTTGGCTATTGTTTGGAAAAGATGAGCTGTCTGTGTAGATAT
GAAGTATAGTTTTTTCCATAAAACAGATGTTTATTTTGTATTAAAAAATACCACTGTACTTGTTTTACACCATTTGTATACATGTGGTGA

>55705_55705_3_MTIF2-SMEK2_MTIF2_chr2_55489452_ENST00000394600_SMEK2_chr2_55842642_ENST00000407823_length(amino acids)=893AA_BP=123
MGLQACATTPRRNMNQKLLKLENLLRFHTIYRQLHSLCQRRALRQWRHGFSSAYPVWTAQLCAWPWPTDVLTGAALSQYRLLVTKKEEGP
WKSQLSSTKSKKVVEVWIGMTIEELARAMEKNTGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKD
PSVEVTQDLIDESEEERFEEMPETSHLIDLPTCELNKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQACENLENTEGLHHL
YEIIRGILFLNKATLFEVMFSDECIMDVVGCLEYDPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQYIQDIILPTPSVFE
ENFLSTLTSFIFFNKVEIVSMLQEDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLAKLGILPALEIVMGM
DDLQVRSAATDIFSYLVEFSPSMVREFVMQEAQQSDDDILLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENMLATTNKTEKSEFLN
FFYNHCMHVLTAPLLTNTSEDKCEKDNIVGSNKNNTICPDNYQTAQLLALILELLTFCVEHHTYHIKNYIMNKDLLRRVLVLMNSKHTFL
ALCALRFMRRIIGLKDEFYNRYITKGNLFEPVINALLDNGTRYNLLNSAVIELFEFIRVEDIKSLTAHIVENFYKALESIEYVQTFKGLK
TKYEQEKDRQNQKLNSVPSILRSNRFRRDAKALEEDEEMWFNEDEEEEGKAVVAPVEKPKPEDDFPDNYEKFMETKKAKESEDKENLPKR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MTIF2-SMEK2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MTIF2-SMEK2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MTIF2-SMEK2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source