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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MTMR2-MAML2 (FusionGDB2 ID:55750)

Fusion Gene Summary for MTMR2-MAML2

check button Fusion gene summary
Fusion gene informationFusion gene name: MTMR2-MAML2
Fusion gene ID: 55750
HgeneTgene
Gene symbol

MTMR2

MAML2

Gene ID

8898

84441

Gene namemyotubularin related protein 2mastermind like transcriptional coactivator 2
SynonymsCMT4B|CMT4B1MAM-3|MAM2|MAM3|MLL-MAML2
Cytomap

11q21

11q21

Type of geneprotein-codingprotein-coding
Descriptionmyotubularin-related protein 2phosphatidylinositol-3,5-bisphosphate 3-phosphatasephosphatidylinositol-3-phosphatasephosphatidylinositol-3-phosphate phosphatasephosphoinositide-3-phosphatasemastermind-like protein 2mam-2mastermind-like 2
Modification date2020032820200313
UniProtAcc

Q13614

Q8IZL2

Ensembl transtripts involved in fusion geneENST00000352297, ENST00000393223, 
ENST00000409459, ENST00000484818, 
ENST00000346299, 		ENST00000524717, 
Fusion gene scores* DoF score8 X 9 X 7=50414 X 24 X 9=3024
# samples 1321
** MAII scorelog2(13/504*10)=-1.95491211047146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/3024*10)=-3.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MTMR2 [Title/Abstract] AND MAML2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMTMR2(95657039)-MAML2(95724887), # samples:2
MTMR2(95598765)-MAML2(95724887), # samples:2
Anticipated loss of major functional domain due to fusion event.MTMR2-MAML2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MTMR2-MAML2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
MTMR2-MAML2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMTMR2

GO:0046856

phosphatidylinositol dephosphorylation

12668758

HgeneMTMR2

GO:0060304

regulation of phosphatidylinositol dephosphorylation

16787938

TgeneMAML2

GO:0007219

Notch signaling pathway

12370315

TgeneMAML2

GO:0045944

positive regulation of transcription by RNA polymerase II

12370315


check buttonFusion gene breakpoints across MTMR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAML2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A18V-01AMTMR2chr11

95657039

-MAML2chr11

95724887

-
ChimerDB4BRCATCGA-E9-A244-01AMTMR2chr11

95598765

-MAML2chr11

95724887

-
ChimerDB4LGGTCGA-HT-7477-01BMTMR2chr11

95621320

-MAML2chr11

95826681

-
ChimerDB4STADTCGA-BR-8678-01AMTMR2chr11

95578117

-MAML2chr11

95724887

-


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Fusion Gene ORF analysis for MTMR2-MAML2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000352297ENST00000524717MTMR2chr11

95657039

-MAML2chr11

95724887

-
5UTR-3CDSENST00000352297ENST00000524717MTMR2chr11

95621320

-MAML2chr11

95826681

-
5UTR-3CDSENST00000393223ENST00000524717MTMR2chr11

95657039

-MAML2chr11

95724887

-
5UTR-3CDSENST00000393223ENST00000524717MTMR2chr11

95621320

-MAML2chr11

95826681

-
5UTR-3CDSENST00000409459ENST00000524717MTMR2chr11

95657039

-MAML2chr11

95724887

-
5UTR-3CDSENST00000409459ENST00000524717MTMR2chr11

95621320

-MAML2chr11

95826681

-
5UTR-3CDSENST00000484818ENST00000524717MTMR2chr11

95598765

-MAML2chr11

95724887

-
5UTR-3CDSENST00000484818ENST00000524717MTMR2chr11

95621320

-MAML2chr11

95826681

-
Frame-shiftENST00000346299ENST00000524717MTMR2chr11

95598765

-MAML2chr11

95724887

-
Frame-shiftENST00000352297ENST00000524717MTMR2chr11

95578117

-MAML2chr11

95724887

-
Frame-shiftENST00000393223ENST00000524717MTMR2chr11

95578117

-MAML2chr11

95724887

-
Frame-shiftENST00000409459ENST00000524717MTMR2chr11

95598765

-MAML2chr11

95724887

-
In-frameENST00000346299ENST00000524717MTMR2chr11

95657039

-MAML2chr11

95724887

-
In-frameENST00000346299ENST00000524717MTMR2chr11

95621320

-MAML2chr11

95826681

-
In-frameENST00000346299ENST00000524717MTMR2chr11

95578117

-MAML2chr11

95724887

-
In-frameENST00000352297ENST00000524717MTMR2chr11

95598765

-MAML2chr11

95724887

-
In-frameENST00000393223ENST00000524717MTMR2chr11

95598765

-MAML2chr11

95724887

-
In-frameENST00000409459ENST00000524717MTMR2chr11

95578117

-MAML2chr11

95724887

-
intron-3CDSENST00000484818ENST00000524717MTMR2chr11

95657039

-MAML2chr11

95724887

-
intron-3CDSENST00000484818ENST00000524717MTMR2chr11

95578117

-MAML2chr11

95724887

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393223MTMR2chr1195598765-ENST00000524717MAML2chr1195724887-43917097932040415
ENST00000352297MTMR2chr1195598765-ENST00000524717MAML2chr1195724887-41614795631810415
ENST00000346299MTMR2chr1195578117-ENST00000524717MAML2chr1195724887-540917272453058937
ENST00000409459MTMR2chr1195578117-ENST00000524717MAML2chr1195724887-535416724753003842
ENST00000346299MTMR2chr1195621320-ENST00000524717MAML2chr1195826681-583552724534841079

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393223ENST00000524717MTMR2chr1195598765-MAML2chr1195724887-0.000267470.99973255
ENST00000352297ENST00000524717MTMR2chr1195598765-MAML2chr1195724887-0.0002183240.99978167
ENST00000346299ENST00000524717MTMR2chr1195578117-MAML2chr1195724887-0.0004659560.999534
ENST00000409459ENST00000524717MTMR2chr1195578117-MAML2chr1195724887-0.0003672990.9996327
ENST00000346299ENST00000524717MTMR2chr1195621320-MAML2chr1195826681-0.0010687010.9989312

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Fusion Genomic Features for MTMR2-MAML2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MTMR2-MAML2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:95657039/chr11:95724887)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTMR2

Q13614

MAML2

Q8IZL2

FUNCTION: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed:11733541, PubMed:12668758, PubMed:21372139, PubMed:14690594). Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (By similarity). Stabilizes SBF2/MTMR13 at the membranes (By similarity). Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein (By similarity). {ECO:0000250|UniProtKB:Q9Z2D1, ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:12668758, ECO:0000269|PubMed:14690594, ECO:0000269|PubMed:21372139}.FUNCTION: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3. {ECO:0000269|PubMed:12370315, ECO:0000269|PubMed:12386158, ECO:0000269|PubMed:12539049}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTMR2chr11:95578117chr11:95724887ENST00000346299-11154_53462644.0Compositional biasSer-rich
HgeneMTMR2chr11:95578117chr11:95724887ENST00000352297-12164_53390572.0Compositional biasSer-rich
HgeneMTMR2chr11:95578117chr11:95724887ENST00000393223-13174_53390572.0Compositional biasSer-rich
HgeneMTMR2chr11:95578117chr11:95724887ENST00000409459-13174_53390572.0Compositional biasSer-rich
HgeneMTMR2chr11:95598765chr11:95724887ENST00000346299-3154_5387644.0Compositional biasSer-rich
HgeneMTMR2chr11:95621320chr11:95826681ENST00000346299-2154_5362644.0Compositional biasSer-rich
HgeneMTMR2chr11:95578117chr11:95724887ENST00000346299-111568_139462644.0DomainGRAM
HgeneMTMR2chr11:95578117chr11:95724887ENST00000352297-121668_139390572.0DomainGRAM
HgeneMTMR2chr11:95578117chr11:95724887ENST00000393223-131768_139390572.0DomainGRAM
HgeneMTMR2chr11:95578117chr11:95724887ENST00000409459-131768_139390572.0DomainGRAM
HgeneMTMR2chr11:95578117chr11:95724887ENST00000346299-1115330_333462644.0RegionSubstrate binding
HgeneMTMR2chr11:95578117chr11:95724887ENST00000346299-1115355_356462644.0RegionSubstrate binding
HgeneMTMR2chr11:95578117chr11:95724887ENST00000346299-1115417_423462644.0RegionSubstrate binding
HgeneMTMR2chr11:95578117chr11:95724887ENST00000352297-1216330_333390572.0RegionSubstrate binding
HgeneMTMR2chr11:95578117chr11:95724887ENST00000352297-1216355_356390572.0RegionSubstrate binding
HgeneMTMR2chr11:95578117chr11:95724887ENST00000393223-1317330_333390572.0RegionSubstrate binding
HgeneMTMR2chr11:95578117chr11:95724887ENST00000393223-1317355_356390572.0RegionSubstrate binding
HgeneMTMR2chr11:95578117chr11:95724887ENST00000409459-1317330_333390572.0RegionSubstrate binding
HgeneMTMR2chr11:95578117chr11:95724887ENST00000409459-1317355_356390572.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTMR2chr11:95578117chr11:95724887ENST00000346299-1115593_627462644.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95578117chr11:95724887ENST00000352297-1216593_627390572.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95578117chr11:95724887ENST00000393223-1317593_627390572.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95578117chr11:95724887ENST00000409459-1317593_627390572.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95598765chr11:95724887ENST00000346299-315593_62787644.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95598765chr11:95724887ENST00000352297-416593_62715572.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95598765chr11:95724887ENST00000393223-517593_62715572.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95598765chr11:95724887ENST00000409459-517593_62715572.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95621320chr11:95826681ENST00000346299-215593_62762644.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95621320chr11:95826681ENST00000352297-316593_6270572.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95621320chr11:95826681ENST00000393223-317593_6270572.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95621320chr11:95826681ENST00000409459-317593_6270572.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95657039chr11:95724887ENST00000346299-115593_62726644.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95657039chr11:95724887ENST00000352297-116593_6270572.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95657039chr11:95724887ENST00000393223-117593_6270572.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95657039chr11:95724887ENST00000409459-117593_6270572.0Coiled coilOntology_term=ECO:0000269
HgeneMTMR2chr11:95598765chr11:95724887ENST00000352297-4164_5315572.0Compositional biasSer-rich
HgeneMTMR2chr11:95598765chr11:95724887ENST00000393223-5174_5315572.0Compositional biasSer-rich
HgeneMTMR2chr11:95598765chr11:95724887ENST00000409459-5174_5315572.0Compositional biasSer-rich
HgeneMTMR2chr11:95621320chr11:95826681ENST00000352297-3164_530572.0Compositional biasSer-rich
HgeneMTMR2chr11:95621320chr11:95826681ENST00000393223-3174_530572.0Compositional biasSer-rich
HgeneMTMR2chr11:95621320chr11:95826681ENST00000409459-3174_530572.0Compositional biasSer-rich
HgeneMTMR2chr11:95657039chr11:95724887ENST00000346299-1154_5326644.0Compositional biasSer-rich
HgeneMTMR2chr11:95657039chr11:95724887ENST00000352297-1164_530572.0Compositional biasSer-rich
HgeneMTMR2chr11:95657039chr11:95724887ENST00000393223-1174_530572.0Compositional biasSer-rich
HgeneMTMR2chr11:95657039chr11:95724887ENST00000409459-1174_530572.0Compositional biasSer-rich
HgeneMTMR2chr11:95578117chr11:95724887ENST00000346299-1115205_580462644.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95578117chr11:95724887ENST00000352297-1216205_580390572.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95578117chr11:95724887ENST00000393223-1317205_580390572.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95578117chr11:95724887ENST00000409459-1317205_580390572.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95598765chr11:95724887ENST00000346299-315205_58087644.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95598765chr11:95724887ENST00000346299-31568_13987644.0DomainGRAM
HgeneMTMR2chr11:95598765chr11:95724887ENST00000352297-416205_58015572.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95598765chr11:95724887ENST00000352297-41668_13915572.0DomainGRAM
HgeneMTMR2chr11:95598765chr11:95724887ENST00000393223-517205_58015572.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95598765chr11:95724887ENST00000393223-51768_13915572.0DomainGRAM
HgeneMTMR2chr11:95598765chr11:95724887ENST00000409459-517205_58015572.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95598765chr11:95724887ENST00000409459-51768_13915572.0DomainGRAM
HgeneMTMR2chr11:95621320chr11:95826681ENST00000346299-215205_58062644.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95621320chr11:95826681ENST00000346299-21568_13962644.0DomainGRAM
HgeneMTMR2chr11:95621320chr11:95826681ENST00000352297-316205_5800572.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95621320chr11:95826681ENST00000352297-31668_1390572.0DomainGRAM
HgeneMTMR2chr11:95621320chr11:95826681ENST00000393223-317205_5800572.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95621320chr11:95826681ENST00000393223-31768_1390572.0DomainGRAM
HgeneMTMR2chr11:95621320chr11:95826681ENST00000409459-317205_5800572.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95621320chr11:95826681ENST00000409459-31768_1390572.0DomainGRAM
HgeneMTMR2chr11:95657039chr11:95724887ENST00000346299-115205_58026644.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95657039chr11:95724887ENST00000346299-11568_13926644.0DomainGRAM
HgeneMTMR2chr11:95657039chr11:95724887ENST00000352297-116205_5800572.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95657039chr11:95724887ENST00000352297-11668_1390572.0DomainGRAM
HgeneMTMR2chr11:95657039chr11:95724887ENST00000393223-117205_5800572.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95657039chr11:95724887ENST00000393223-11768_1390572.0DomainGRAM
HgeneMTMR2chr11:95657039chr11:95724887ENST00000409459-117205_5800572.0DomainMyotubularin phosphatase
HgeneMTMR2chr11:95657039chr11:95724887ENST00000409459-11768_1390572.0DomainGRAM
HgeneMTMR2chr11:95578117chr11:95724887ENST00000352297-1216417_423390572.0RegionSubstrate binding
HgeneMTMR2chr11:95578117chr11:95724887ENST00000393223-1317417_423390572.0RegionSubstrate binding
HgeneMTMR2chr11:95578117chr11:95724887ENST00000409459-1317417_423390572.0RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000346299-315330_33387644.0RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000346299-315355_35687644.0RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000346299-315417_42387644.0RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000352297-416330_33315572.0RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000352297-416355_35615572.0RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000352297-416417_42315572.0RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000393223-517330_33315572.0RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000393223-517355_35615572.0RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000393223-517417_42315572.0RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000409459-517330_33315572.0RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000409459-517355_35615572.0RegionSubstrate binding
HgeneMTMR2chr11:95598765chr11:95724887ENST00000409459-517417_42315572.0RegionSubstrate binding
HgeneMTMR2chr11:95621320chr11:95826681ENST00000346299-215330_33362644.0RegionSubstrate binding
HgeneMTMR2chr11:95621320chr11:95826681ENST00000346299-215355_35662644.0RegionSubstrate binding
HgeneMTMR2chr11:95621320chr11:95826681ENST00000346299-215417_42362644.0RegionSubstrate binding
HgeneMTMR2chr11:95621320chr11:95826681ENST00000352297-316330_3330572.0RegionSubstrate binding
HgeneMTMR2chr11:95621320chr11:95826681ENST00000352297-316355_3560572.0RegionSubstrate binding
HgeneMTMR2chr11:95621320chr11:95826681ENST00000352297-316417_4230572.0RegionSubstrate binding
HgeneMTMR2chr11:95621320chr11:95826681ENST00000393223-317330_3330572.0RegionSubstrate binding
HgeneMTMR2chr11:95621320chr11:95826681ENST00000393223-317355_3560572.0RegionSubstrate binding
HgeneMTMR2chr11:95621320chr11:95826681ENST00000393223-317417_4230572.0RegionSubstrate binding
HgeneMTMR2chr11:95621320chr11:95826681ENST00000409459-317330_3330572.0RegionSubstrate binding
HgeneMTMR2chr11:95621320chr11:95826681ENST00000409459-317355_3560572.0RegionSubstrate binding
HgeneMTMR2chr11:95621320chr11:95826681ENST00000409459-317417_4230572.0RegionSubstrate binding
HgeneMTMR2chr11:95657039chr11:95724887ENST00000346299-115330_33326644.0RegionSubstrate binding
HgeneMTMR2chr11:95657039chr11:95724887ENST00000346299-115355_35626644.0RegionSubstrate binding
HgeneMTMR2chr11:95657039chr11:95724887ENST00000346299-115417_42326644.0RegionSubstrate binding
HgeneMTMR2chr11:95657039chr11:95724887ENST00000352297-116330_3330572.0RegionSubstrate binding
HgeneMTMR2chr11:95657039chr11:95724887ENST00000352297-116355_3560572.0RegionSubstrate binding
HgeneMTMR2chr11:95657039chr11:95724887ENST00000352297-116417_4230572.0RegionSubstrate binding
HgeneMTMR2chr11:95657039chr11:95724887ENST00000393223-117330_3330572.0RegionSubstrate binding
HgeneMTMR2chr11:95657039chr11:95724887ENST00000393223-117355_3560572.0RegionSubstrate binding
HgeneMTMR2chr11:95657039chr11:95724887ENST00000393223-117417_4230572.0RegionSubstrate binding
HgeneMTMR2chr11:95657039chr11:95724887ENST00000409459-117330_3330572.0RegionSubstrate binding
HgeneMTMR2chr11:95657039chr11:95724887ENST00000409459-117355_3560572.0RegionSubstrate binding
HgeneMTMR2chr11:95657039chr11:95724887ENST00000409459-117417_4230572.0RegionSubstrate binding


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Fusion Gene Sequence for MTMR2-MAML2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>55750_55750_1_MTMR2-MAML2_MTMR2_chr11_95578117_ENST00000346299_MAML2_chr11_95724887_ENST00000524717_length(transcript)=5409nt_BP=1727nt
CTCCTTCCATAAGGGTCTGGTCCTTCATCCCTCCCGCTTCACCAGACCCCCTCACCCTGGGAGCCGCCACCTCCCTTTCCCCAAGACCAG
ATGTCGCGCGGCCGGACACAGCCAGCACGGAGAGTCGATGCCGGCGTCTGAGCTGCGCAGTGGGGTCTTCCCGCTGCCCAGCAGCCTACA
GGCGCGGTGCACTCTGGGGGAACATGGCCGCTTCCGGTCTCCCTCCCGGGCCGGCGCTGGCCTGACTGCGGCCCCGGTCCGTAGCACTCC
GCCCTCCGCTTCTCCCGCCCTGTAGCCGCGAAGACTGCTTCAGCCTTTCCCTGTGCTGCCCCTGCCGCGCGATGGAGAAGAGCTCGAGCT
GCGAGAGTCTTGGCTCCCAGCCGGCGGCGGCTCGGCCGCCCAGCGTGGACTCCTTGTCCAGTGCCTCCACTTCTCATTCAGAGAATTCAG
TGCATACAAAATCAGCTTCTGTTGTATCATCAGATTCCATTTCAACTTCTGCCGACAACTTTTCTCCTGATTTGAGGGTCCTGAGGGAGT
CTAACAAGTTAGCAGAAATGGAAGAACCACCCTTGCTTCCAGGAGAAAATATTAAAGACATGGCCAAAGATGTAACTTATATATGTCCAT
TCACTGGCGCTGTACGAGGAACTCTGACTGTCACGAATTATAGGTTATATTTCAAAAGCATGGAACGGGATCCCCCATTTGTTTTAGATG
CTTCCCTTGGTGTGATAAATAGAGTAGAAAAAATTGGTGGTGCTTCTAGTCGAGGTGAAAATTCTTATGGACTAGAAACTGTGTGTAAGG
ATATTAGGAATTTACGATTTGCTCATAAACCTGAGGGGCGGACAAGAAGATCCATATTTGAGAATCTAATGAAATATGCATTTCCTGTCT
CTAATAACCTGCCTCTTTTTGCTTTTGAATACAAAGAAGTATTCCCTGAAAATGGGTGGAAGCTATATGACCCTCTTTTAGAGTATAGAA
GGCAGGGAATTCCAAATGAAAGCTGGAGAATAACAAAGATAAATGAACGATATGAACTTTGTGATACATACCCTGCCCTCCTGGTTGTGC
CAGCAAATATTCCTGATGAAGAATTAAAGAGAGTGGCATCCTTCAGATCAAGAGGCCGTATCCCAGTTTTATCATGGATTCATCCTGAAA
GTCAAGCCACAATCACTCGGTGTAGCCAGCCCATGGTTGGAGTGAGTGGAAAGCGAAGCAAAGAAGATGAAAAATACCTTCAAGCTATCA
TGGATTCCAATGCCCAGTCTCACAAAATCTTTATATTTGATGCCCGGCCAAGTGTTAATGCTGTTGCCAACAAGGCAAAGGGTGGAGGTT
ATGAAAGTGAAGATGCCTATCAAAATGCTGAACTAGTTTTCCTGGATATCCACAATATTCATGTTATGAGAGAATCATTACGAAAACTTA
AGGAGATTGTGTACCCCAACATTGAGGAAACCCACTGGTTGTCTAACTTGGAATCTACTCATTGGCTAGAACATATTAAGCTTATTCTTG
CAGGGGCTCTTAGGATTGCTGACAAGGTAGAGTCAGGGAAGACGTCTGTGGTAGTGCATTGCAGTGATGGTTGGGATCGCACAGCTCAGC
TCACTTCCCTTGCCATGCTCATGTTGGATGGATACTATCGAACCATCCGAGGATTTGAAGTCCTTGTGGAGAAAGAATGGCTAAGTTTTG
GACATCGATTTCAACTAGATCAACACTCTGTGGTAGGCCAGAACACAGGCCCCAGTCCAAGTCCTAACCCCTGCTCAAATCCAAACACTG
GAAGTGGTTACATGAACTCCCAGCAATCACTGTTGAATCAGCAATTGATGGGAAAGAAGCAGACTCTACAGAGGCAGATCATGGAGCAGA
AACAGCAACTTCTTCTCCAGCAGCAGATGCTGGCTGACGCGGAGAAAATTGCTCCACAAGATCAGATAAACCGACATTTGTCAAGGCCAC
CTCCAGATTATAAAGACCAAAGAAGAAATGTGGGCAATATGCAACCAACTGCTCAGTATTCTGGTGGCTCATCCACAATAAGCTTAAACT
CTAACCAGGCTTTGGCAAACCCAGTTTCAACACACACCATTTTAACTCCCAATTCCAGCCTCCTGTCTACTTCTCACGGGACAAGAATGC
CATCATTATCTACAGCAGTTCAGAATATGGGGATGTATGGAAATCTGCCTTGTAATCAACCTAACACATACAGTGTCACTTCAGGAATGA
ATCAATTGACCCAACAGAGAAACCCAAAGCAATTGTTAGCAAATCAAAACAACCCTATGATGCCACGGCCACCTACCTTAGGGCCAAGTA
ATAATAACAATGTAGCCACTTTTGGAGCTGGATCTGTTGGTAATTCACAACAATTGAGACCAAATTTAACCCATAGTATGGCAAGCATGC
CACCACAGAGAACATCAAACGTAATGATCACATCCAACACAACTGCACCAAACTGGGCCTCTCAAGAAGGAACAAGCAAACAGCAAGAAG
CCCTGACGTCTGCAGGAGTCCGCTTCCCCACAGGTACACCTGCAGCCTATACCCCAAATCAGTCACTGCAACAGGCAGTAGGTAGCCAGC
AATTTTCCCAGAGGGCAGTGGCTCCTCCTAACCAGTTAACACCAGCAGTGCAAATGAGACCCATGAACCAAATGAGCCAAACACTAAATG
GGCAAACCATGGGTCCCCTCAGGGGTCTGAATCTCAGACCCAATCAGCTAAGCACACAGATTTTGCCTAATTTGAATCAGTCAGGAACAG
GGTTGAATCAGTCGAGGACGGGCATCAACCAGCCACCATCCCTGACGCCCAGCAATTTTCCTTCACCCAACCAAAGTTCCAGGGCTTTTC
AAGGAACTGACCACAGCAGTGACTTAGCTTTTGACTTCCTCAGCCAACAAAATGATAACATGGGCCCTGCCCTAAACAGTGATGCTGATT
TCATTGATTCTTTATTGAAGACAGAGCCTGGTAATGATGACTGGATGAAAGACATCAATCTTGATGAAATCTTGGGGAACAATTCCTAAA
GAAGAAAGGGAAGACAATTTACAAACTCCAAGCACTAAAAGGCAGTATATTACAGAAACTCTGTAGAGGCTGAACTGTTGATGTTCAGGT
GGACTACATGAAGATAACATGCTTAAAAATGGAAAGCAGAAAGTAACTGCAGTGATGAACATTTTGGTCCAAATTCTTGTTTTAAATCTT
ACACCTGAAAGTAAAATATTGGGATCACTTTTCCCTGTCTAAACTCCAGGATACAGTATCCAATTTATCCAAACAGAACTGTGGTGTCAA
TGTGTAATTAATTGTGTAAAATAGCCTTCCCAAGTTTCTTTTTCCCTGGAAAATAAAAAAGGTAATAGAACTTGTAGTTTATTTAAACCC
CATGTCATGAGGAGGTACTAGTTCCAAGCAACAAACTCCTTAATTTGCTCTAATAGATAGGTATGGTTTAATCTTTCCATTGTGTCTTTT
CATTTAATTTTCCTGAAGCTTGCAGGATAGATTGAAATGTTATAGGTTTGTTTGGAGTAACCAAACAGTATGCAAATTAAGAAAAAGCCA
GAGAACCTAGAAAACATCCAGTGGATTACAGAATTTCTTCCCCATATTCACTCCTCACTTTTACAATTTTCCCACAATCCTCTACTTCAG
TGGGATGCTGTGTCTAGTGATTAAACAAAAATATAGAGCTGTGCAATTTGATTTTGGCTTCCACAACGAATATCTGAATCCATTCCAAAT
GAAATTTTAGATATAACAAAGACTTGTCCTAATCATACTGAAATATTGGTGCACACCTCTCTGCATTAGATTTCACTTTTTTAAAAAACC
CAGTGGACATTGCTATAAATAAGATTTATTTGGCTACAAATAACCTGGGATGTTGCTTATTATGATTGATGCCTGCTGGTTTGTTCCCAA
GCTGAGTGAAATTGAACCTCGTCCTCCCTACTCATTTTGATGACTGAGGCTGGTTTATAAGAAAAGGAAGTTTGGAGAAGAAAACCGAGA
TTAGAAAATATCATGTTTTGGTTGGAGATAAGAACCAGGGATGGCAAGTACCAGTGTGTACAAATGTATTTCACGGAGTTTGAAGGAACG
CATAATCAAGAGGGAAAACAATTTGTCCTTCATTGGACGTATTATTTGGATTTGGGTGAGCAACAAAATGGAATGTGGTCTGTTAGGAGC
ATTCTGTTTGTTCTTTTGTCCCTGATGTGATGAATCATTGCCACATGCTAGATGGACTCTTCATATCCAGGTTTTGTCCCTCAGGGCTGA
GCACTGTATTAAAGAGTTTTTGTTGAGTCATTTAACCTTAGTGTCCACATCCAGATCAGCTGTAAAATGGGGAAGACGTGTGCTGATTTG
GAATGAATGCAAAATATCACTATCATTTTCCTAATTACAGAGGAGCAAAGGTTATCTTCAGCCCTTTCAGTTCTATGCTCACATATTCAA
ATATCAAATGTAATTTAGCTGAAGTTATTTAATAATCAAGTCTTTCAATATCTGTTCAAAGAAAAAGAACACACTTTGAAAATTCTGCAA
AGCTGTCTCCCAGTCTTTAAAATGTCTGGAAGCACTCTCCTTCTTTACAATACCAACATCACTGGCCCAGAATCTTCCCTGTGCTAGTTT
GTAAATATAAATAAATTACTTGTTTTGTAAACTTTTGTAAAGAATATTTTGGTAGAAATACTTCAAACATATTCTTTGGGTTATATTTAT
ACATATGTGAAATAAATATACTATCAAAAGGTTATATTTTATACAAAAAGTAAATTGCTACCTTTTGTATGCTAATATGCAAAGTTTTGT
ATAATATGATGGTTTATTTTTAGCTCTACACTTAAACCATAGGTGGTTGAGTGGGAACTTTTGAAAACTATCAAGAGGCTTGTTAGACAA
ATTTATATTCTGAAACCTCAATAAGAAAGCATTCCAGGTTTCAATCCTTGTTTTTTGTCCTGCTCCCAAATTCTTTTTTAAACCCATAGT
TCTTGTGTCTTATTTGATTCTTCTGCTGTGCACATTGTATTGGTCCTTGTTGCATGTAGTCTACTGTGTGTTTTCCGATTTTATAAGGCA
GCATTTCTCCATACAAAAAGAAAAAAAATGATGTACATATAAACGCTTTTGTTGTATGGCTCCTCCATGTTACTGTATATATCTGCCAGC
ACTTCCCAGTTACACTCCTGTGAGTCAGCTTATTTTTACCCTAACATAAATAGTATGTTTTGTAGTAGTTATCAAATTTAAGAGATAAAG
CAATCAGAATGTTTGGATTTTCTTCTATCTTAATGTGAATTTCATAATTAATGTCTATTTATTCAGCTATTCATTAAAATACAGGATTCT

>55750_55750_1_MTMR2-MAML2_MTMR2_chr11_95578117_ENST00000346299_MAML2_chr11_95724887_ENST00000524717_length(amino acids)=937AA_BP=494
MRPRSVALRPPLLPPCSREDCFSLSLCCPCRAMEKSSSCESLGSQPAAARPPSVDSLSSASTSHSENSVHTKSASVVSSDSISTSADNFS
PDLRVLRESNKLAEMEEPPLLPGENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYFKSMERDPPFVLDASLGVINRVEKIGGASSRGENS
YGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAFEYKEVFPENGWKLYDPLLEYRRQGIPNESWRITKINERYELCD
TYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAV
ANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCS
DGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLDQHSVVGQNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQT
LQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLL
STSHGTRMPSLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNNVATFGAGSVGNSQQLRPN
LTHSMASMPPQRTSNVMITSNTTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQLTPAVQMRPM
NQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQGTDHSSDLAFDFLSQQNDNMG

--------------------------------------------------------------
>55750_55750_2_MTMR2-MAML2_MTMR2_chr11_95578117_ENST00000409459_MAML2_chr11_95724887_ENST00000524717_length(transcript)=5354nt_BP=1672nt
GAACATGGCCGCTTCCGGTCTCCCTCCCGGGCCGGCGCTGGCCTGACTGCGGCCCCGGTCCGTAGCACTCCGCCCTCCGCTTCTCCCGCC
CTGTAGCCGCGAAGACTGCTTCAGCCTTTCCCTGTGCTGCCCCTGCCGCGCGATGGAGAAGAGCTCGAGCTGCGAGAGTCTTGGCTCCCA
GCCGGCGGCGGCTCGGCCGCCCAGCGTGGACTCCTTGTCCAGTTAATGTGTTAAGAGCCATTGACATTTGAAGATCATCAGAAGTGAAGA
TAAAACATCTCAAAAATTATAATTGCCTCCACTTCTCATTCAGAGAATTCAGTGCATACAAAATCAGCTTCTGTTGTATCATCAGATTCC
ATTTCAACTTCTGCCGACAACTTTTCTCCTGATTTGAGGCCCATGCAGTCCAGTTCGGGAGCTAAGTCACTTAAACACTGTGTGATAGTT
CCTACACATCTCATTATAGTTTGTCCTGAGGGAGTCTAACAAGTTAGCAGAAATGGAAGAACCACCCTTGCTTCCAGGAGAAAATATTAA
AGACATGGCCAAAGATGTAACTTATATATGTCCATTCACTGGCGCTGTACGAGGAACTCTGACTGTCACGAATTATAGGTTATATTTCAA
AAGCATGGAACGGGATCCCCCATTTGTTTTAGATGCTTCCCTTGGTGTGATAAATAGAGTAGAAAAAATTGGTGGTGCTTCTAGTCGAGG
TGAAAATTCTTATGGACTAGAAACTGTGTGTAAGGATATTAGGAATTTACGATTTGCTCATAAACCTGAGGGGCGGACAAGAAGATCCAT
ATTTGAGAATCTAATGAAATATGCATTTCCTGTCTCTAATAACCTGCCTCTTTTTGCTTTTGAATACAAAGAAGTATTCCCTGAAAATGG
GTGGAAGCTATATGACCCTCTTTTAGAGTATAGAAGGCAGGGAATTCCAAATGAAAGCTGGAGAATAACAAAGATAAATGAACGATATGA
ACTTTGTGATACATACCCTGCCCTCCTGGTTGTGCCAGCAAATATTCCTGATGAAGAATTAAAGAGAGTGGCATCCTTCAGATCAAGAGG
CCGTATCCCAGTTTTATCATGGATTCATCCTGAAAGTCAAGCCACAATCACTCGGTGTAGCCAGCCCATGGTTGGAGTGAGTGGAAAGCG
AAGCAAAGAAGATGAAAAATACCTTCAAGCTATCATGGATTCCAATGCCCAGTCTCACAAAATCTTTATATTTGATGCCCGGCCAAGTGT
TAATGCTGTTGCCAACAAGGCAAAGGGTGGAGGTTATGAAAGTGAAGATGCCTATCAAAATGCTGAACTAGTTTTCCTGGATATCCACAA
TATTCATGTTATGAGAGAATCATTACGAAAACTTAAGGAGATTGTGTACCCCAACATTGAGGAAACCCACTGGTTGTCTAACTTGGAATC
TACTCATTGGCTAGAACATATTAAGCTTATTCTTGCAGGGGCTCTTAGGATTGCTGACAAGGTAGAGTCAGGGAAGACGTCTGTGGTAGT
GCATTGCAGTGATGGTTGGGATCGCACAGCTCAGCTCACTTCCCTTGCCATGCTCATGTTGGATGGATACTATCGAACCATCCGAGGATT
TGAAGTCCTTGTGGAGAAAGAATGGCTAAGTTTTGGACATCGATTTCAACTAGATCAACACTCTGTGGTAGGCCAGAACACAGGCCCCAG
TCCAAGTCCTAACCCCTGCTCAAATCCAAACACTGGAAGTGGTTACATGAACTCCCAGCAATCACTGTTGAATCAGCAATTGATGGGAAA
GAAGCAGACTCTACAGAGGCAGATCATGGAGCAGAAACAGCAACTTCTTCTCCAGCAGCAGATGCTGGCTGACGCGGAGAAAATTGCTCC
ACAAGATCAGATAAACCGACATTTGTCAAGGCCACCTCCAGATTATAAAGACCAAAGAAGAAATGTGGGCAATATGCAACCAACTGCTCA
GTATTCTGGTGGCTCATCCACAATAAGCTTAAACTCTAACCAGGCTTTGGCAAACCCAGTTTCAACACACACCATTTTAACTCCCAATTC
CAGCCTCCTGTCTACTTCTCACGGGACAAGAATGCCATCATTATCTACAGCAGTTCAGAATATGGGGATGTATGGAAATCTGCCTTGTAA
TCAACCTAACACATACAGTGTCACTTCAGGAATGAATCAATTGACCCAACAGAGAAACCCAAAGCAATTGTTAGCAAATCAAAACAACCC
TATGATGCCACGGCCACCTACCTTAGGGCCAAGTAATAATAACAATGTAGCCACTTTTGGAGCTGGATCTGTTGGTAATTCACAACAATT
GAGACCAAATTTAACCCATAGTATGGCAAGCATGCCACCACAGAGAACATCAAACGTAATGATCACATCCAACACAACTGCACCAAACTG
GGCCTCTCAAGAAGGAACAAGCAAACAGCAAGAAGCCCTGACGTCTGCAGGAGTCCGCTTCCCCACAGGTACACCTGCAGCCTATACCCC
AAATCAGTCACTGCAACAGGCAGTAGGTAGCCAGCAATTTTCCCAGAGGGCAGTGGCTCCTCCTAACCAGTTAACACCAGCAGTGCAAAT
GAGACCCATGAACCAAATGAGCCAAACACTAAATGGGCAAACCATGGGTCCCCTCAGGGGTCTGAATCTCAGACCCAATCAGCTAAGCAC
ACAGATTTTGCCTAATTTGAATCAGTCAGGAACAGGGTTGAATCAGTCGAGGACGGGCATCAACCAGCCACCATCCCTGACGCCCAGCAA
TTTTCCTTCACCCAACCAAAGTTCCAGGGCTTTTCAAGGAACTGACCACAGCAGTGACTTAGCTTTTGACTTCCTCAGCCAACAAAATGA
TAACATGGGCCCTGCCCTAAACAGTGATGCTGATTTCATTGATTCTTTATTGAAGACAGAGCCTGGTAATGATGACTGGATGAAAGACAT
CAATCTTGATGAAATCTTGGGGAACAATTCCTAAAGAAGAAAGGGAAGACAATTTACAAACTCCAAGCACTAAAAGGCAGTATATTACAG
AAACTCTGTAGAGGCTGAACTGTTGATGTTCAGGTGGACTACATGAAGATAACATGCTTAAAAATGGAAAGCAGAAAGTAACTGCAGTGA
TGAACATTTTGGTCCAAATTCTTGTTTTAAATCTTACACCTGAAAGTAAAATATTGGGATCACTTTTCCCTGTCTAAACTCCAGGATACA
GTATCCAATTTATCCAAACAGAACTGTGGTGTCAATGTGTAATTAATTGTGTAAAATAGCCTTCCCAAGTTTCTTTTTCCCTGGAAAATA
AAAAAGGTAATAGAACTTGTAGTTTATTTAAACCCCATGTCATGAGGAGGTACTAGTTCCAAGCAACAAACTCCTTAATTTGCTCTAATA
GATAGGTATGGTTTAATCTTTCCATTGTGTCTTTTCATTTAATTTTCCTGAAGCTTGCAGGATAGATTGAAATGTTATAGGTTTGTTTGG
AGTAACCAAACAGTATGCAAATTAAGAAAAAGCCAGAGAACCTAGAAAACATCCAGTGGATTACAGAATTTCTTCCCCATATTCACTCCT
CACTTTTACAATTTTCCCACAATCCTCTACTTCAGTGGGATGCTGTGTCTAGTGATTAAACAAAAATATAGAGCTGTGCAATTTGATTTT
GGCTTCCACAACGAATATCTGAATCCATTCCAAATGAAATTTTAGATATAACAAAGACTTGTCCTAATCATACTGAAATATTGGTGCACA
CCTCTCTGCATTAGATTTCACTTTTTTAAAAAACCCAGTGGACATTGCTATAAATAAGATTTATTTGGCTACAAATAACCTGGGATGTTG
CTTATTATGATTGATGCCTGCTGGTTTGTTCCCAAGCTGAGTGAAATTGAACCTCGTCCTCCCTACTCATTTTGATGACTGAGGCTGGTT
TATAAGAAAAGGAAGTTTGGAGAAGAAAACCGAGATTAGAAAATATCATGTTTTGGTTGGAGATAAGAACCAGGGATGGCAAGTACCAGT
GTGTACAAATGTATTTCACGGAGTTTGAAGGAACGCATAATCAAGAGGGAAAACAATTTGTCCTTCATTGGACGTATTATTTGGATTTGG
GTGAGCAACAAAATGGAATGTGGTCTGTTAGGAGCATTCTGTTTGTTCTTTTGTCCCTGATGTGATGAATCATTGCCACATGCTAGATGG
ACTCTTCATATCCAGGTTTTGTCCCTCAGGGCTGAGCACTGTATTAAAGAGTTTTTGTTGAGTCATTTAACCTTAGTGTCCACATCCAGA
TCAGCTGTAAAATGGGGAAGACGTGTGCTGATTTGGAATGAATGCAAAATATCACTATCATTTTCCTAATTACAGAGGAGCAAAGGTTAT
CTTCAGCCCTTTCAGTTCTATGCTCACATATTCAAATATCAAATGTAATTTAGCTGAAGTTATTTAATAATCAAGTCTTTCAATATCTGT
TCAAAGAAAAAGAACACACTTTGAAAATTCTGCAAAGCTGTCTCCCAGTCTTTAAAATGTCTGGAAGCACTCTCCTTCTTTACAATACCA
ACATCACTGGCCCAGAATCTTCCCTGTGCTAGTTTGTAAATATAAATAAATTACTTGTTTTGTAAACTTTTGTAAAGAATATTTTGGTAG
AAATACTTCAAACATATTCTTTGGGTTATATTTATACATATGTGAAATAAATATACTATCAAAAGGTTATATTTTATACAAAAAGTAAAT
TGCTACCTTTTGTATGCTAATATGCAAAGTTTTGTATAATATGATGGTTTATTTTTAGCTCTACACTTAAACCATAGGTGGTTGAGTGGG
AACTTTTGAAAACTATCAAGAGGCTTGTTAGACAAATTTATATTCTGAAACCTCAATAAGAAAGCATTCCAGGTTTCAATCCTTGTTTTT
TGTCCTGCTCCCAAATTCTTTTTTAAACCCATAGTTCTTGTGTCTTATTTGATTCTTCTGCTGTGCACATTGTATTGGTCCTTGTTGCAT
GTAGTCTACTGTGTGTTTTCCGATTTTATAAGGCAGCATTTCTCCATACAAAAAGAAAAAAAATGATGTACATATAAACGCTTTTGTTGT
ATGGCTCCTCCATGTTACTGTATATATCTGCCAGCACTTCCCAGTTACACTCCTGTGAGTCAGCTTATTTTTACCCTAACATAAATAGTA
TGTTTTGTAGTAGTTATCAAATTTAAGAGATAAAGCAATCAGAATGTTTGGATTTTCTTCTATCTTAATGTGAATTTCATAATTAATGTC

>55750_55750_2_MTMR2-MAML2_MTMR2_chr11_95578117_ENST00000409459_MAML2_chr11_95724887_ENST00000524717_length(amino acids)=842AA_BP=399
MRESNKLAEMEEPPLLPGENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYFKSMERDPPFVLDASLGVINRVEKIGGASSRGENSYGLET
VCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAFEYKEVFPENGWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPAL
LVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAK
GGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDR
TAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLDQHSVVGQNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQRQI
MEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLSTSHG
TRMPSLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNNVATFGAGSVGNSQQLRPNLTHSM
ASMPPQRTSNVMITSNTTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQLTPAVQMRPMNQMSQ
TLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQGTDHSSDLAFDFLSQQNDNMGPALNS

--------------------------------------------------------------
>55750_55750_3_MTMR2-MAML2_MTMR2_chr11_95598765_ENST00000352297_MAML2_chr11_95724887_ENST00000524717_length(transcript)=4161nt_BP=479nt
GGGGGAACATGGCCGCTTCCGGTCTCCCTCCCGGGCCGGCGCTGGCCTGACTGCGGCCCCGGTCCGTAGCACTCCGCCCTCCGCTTCTCC
CGCCCTGTAGCCGCGAAGACTGCTTCAGCCTTTCCCTGTGCTGCCCCTGCCGCGCGATGGAGAAGAGCTCGAGCTGCGAGAGTCTTGGCT
CCCAGCCGGCGGCGGCTCGGCCGCCCAGCGTGGACTCCTTGTCCAGTTAATGTGTTAAGAGCCATTGACATTTGAAGATCATCAGAAGTG
AAGATAAAACATCTCAAAAATTATAATTGCCTCCACTTCTCATTCAGAGAATTCAGTGCATACAAAATCAGCTTCTGTTGTATCATCAGA
TTCCATTTCAACTTCTGCCGACAACTTTTCTCCTGATTTGAGGGTCCTGAGGGAGTCTAACAAGTTAGCAGAAATGGAAGAACCACCCTT
GCTTCCAGGAGAAAATATTAAAGACATGGGATCAACACTCTGTGGTAGGCCAGAACACAGGCCCCAGTCCAAGTCCTAACCCCTGCTCAA
ATCCAAACACTGGAAGTGGTTACATGAACTCCCAGCAATCACTGTTGAATCAGCAATTGATGGGAAAGAAGCAGACTCTACAGAGGCAGA
TCATGGAGCAGAAACAGCAACTTCTTCTCCAGCAGCAGATGCTGGCTGACGCGGAGAAAATTGCTCCACAAGATCAGATAAACCGACATT
TGTCAAGGCCACCTCCAGATTATAAAGACCAAAGAAGAAATGTGGGCAATATGCAACCAACTGCTCAGTATTCTGGTGGCTCATCCACAA
TAAGCTTAAACTCTAACCAGGCTTTGGCAAACCCAGTTTCAACACACACCATTTTAACTCCCAATTCCAGCCTCCTGTCTACTTCTCACG
GGACAAGAATGCCATCATTATCTACAGCAGTTCAGAATATGGGGATGTATGGAAATCTGCCTTGTAATCAACCTAACACATACAGTGTCA
CTTCAGGAATGAATCAATTGACCCAACAGAGAAACCCAAAGCAATTGTTAGCAAATCAAAACAACCCTATGATGCCACGGCCACCTACCT
TAGGGCCAAGTAATAATAACAATGTAGCCACTTTTGGAGCTGGATCTGTTGGTAATTCACAACAATTGAGACCAAATTTAACCCATAGTA
TGGCAAGCATGCCACCACAGAGAACATCAAACGTAATGATCACATCCAACACAACTGCACCAAACTGGGCCTCTCAAGAAGGAACAAGCA
AACAGCAAGAAGCCCTGACGTCTGCAGGAGTCCGCTTCCCCACAGGTACACCTGCAGCCTATACCCCAAATCAGTCACTGCAACAGGCAG
TAGGTAGCCAGCAATTTTCCCAGAGGGCAGTGGCTCCTCCTAACCAGTTAACACCAGCAGTGCAAATGAGACCCATGAACCAAATGAGCC
AAACACTAAATGGGCAAACCATGGGTCCCCTCAGGGGTCTGAATCTCAGACCCAATCAGCTAAGCACACAGATTTTGCCTAATTTGAATC
AGTCAGGAACAGGGTTGAATCAGTCGAGGACGGGCATCAACCAGCCACCATCCCTGACGCCCAGCAATTTTCCTTCACCCAACCAAAGTT
CCAGGGCTTTTCAAGGAACTGACCACAGCAGTGACTTAGCTTTTGACTTCCTCAGCCAACAAAATGATAACATGGGCCCTGCCCTAAACA
GTGATGCTGATTTCATTGATTCTTTATTGAAGACAGAGCCTGGTAATGATGACTGGATGAAAGACATCAATCTTGATGAAATCTTGGGGA
ACAATTCCTAAAGAAGAAAGGGAAGACAATTTACAAACTCCAAGCACTAAAAGGCAGTATATTACAGAAACTCTGTAGAGGCTGAACTGT
TGATGTTCAGGTGGACTACATGAAGATAACATGCTTAAAAATGGAAAGCAGAAAGTAACTGCAGTGATGAACATTTTGGTCCAAATTCTT
GTTTTAAATCTTACACCTGAAAGTAAAATATTGGGATCACTTTTCCCTGTCTAAACTCCAGGATACAGTATCCAATTTATCCAAACAGAA
CTGTGGTGTCAATGTGTAATTAATTGTGTAAAATAGCCTTCCCAAGTTTCTTTTTCCCTGGAAAATAAAAAAGGTAATAGAACTTGTAGT
TTATTTAAACCCCATGTCATGAGGAGGTACTAGTTCCAAGCAACAAACTCCTTAATTTGCTCTAATAGATAGGTATGGTTTAATCTTTCC
ATTGTGTCTTTTCATTTAATTTTCCTGAAGCTTGCAGGATAGATTGAAATGTTATAGGTTTGTTTGGAGTAACCAAACAGTATGCAAATT
AAGAAAAAGCCAGAGAACCTAGAAAACATCCAGTGGATTACAGAATTTCTTCCCCATATTCACTCCTCACTTTTACAATTTTCCCACAAT
CCTCTACTTCAGTGGGATGCTGTGTCTAGTGATTAAACAAAAATATAGAGCTGTGCAATTTGATTTTGGCTTCCACAACGAATATCTGAA
TCCATTCCAAATGAAATTTTAGATATAACAAAGACTTGTCCTAATCATACTGAAATATTGGTGCACACCTCTCTGCATTAGATTTCACTT
TTTTAAAAAACCCAGTGGACATTGCTATAAATAAGATTTATTTGGCTACAAATAACCTGGGATGTTGCTTATTATGATTGATGCCTGCTG
GTTTGTTCCCAAGCTGAGTGAAATTGAACCTCGTCCTCCCTACTCATTTTGATGACTGAGGCTGGTTTATAAGAAAAGGAAGTTTGGAGA
AGAAAACCGAGATTAGAAAATATCATGTTTTGGTTGGAGATAAGAACCAGGGATGGCAAGTACCAGTGTGTACAAATGTATTTCACGGAG
TTTGAAGGAACGCATAATCAAGAGGGAAAACAATTTGTCCTTCATTGGACGTATTATTTGGATTTGGGTGAGCAACAAAATGGAATGTGG
TCTGTTAGGAGCATTCTGTTTGTTCTTTTGTCCCTGATGTGATGAATCATTGCCACATGCTAGATGGACTCTTCATATCCAGGTTTTGTC
CCTCAGGGCTGAGCACTGTATTAAAGAGTTTTTGTTGAGTCATTTAACCTTAGTGTCCACATCCAGATCAGCTGTAAAATGGGGAAGACG
TGTGCTGATTTGGAATGAATGCAAAATATCACTATCATTTTCCTAATTACAGAGGAGCAAAGGTTATCTTCAGCCCTTTCAGTTCTATGC
TCACATATTCAAATATCAAATGTAATTTAGCTGAAGTTATTTAATAATCAAGTCTTTCAATATCTGTTCAAAGAAAAAGAACACACTTTG
AAAATTCTGCAAAGCTGTCTCCCAGTCTTTAAAATGTCTGGAAGCACTCTCCTTCTTTACAATACCAACATCACTGGCCCAGAATCTTCC
CTGTGCTAGTTTGTAAATATAAATAAATTACTTGTTTTGTAAACTTTTGTAAAGAATATTTTGGTAGAAATACTTCAAACATATTCTTTG
GGTTATATTTATACATATGTGAAATAAATATACTATCAAAAGGTTATATTTTATACAAAAAGTAAATTGCTACCTTTTGTATGCTAATAT
GCAAAGTTTTGTATAATATGATGGTTTATTTTTAGCTCTACACTTAAACCATAGGTGGTTGAGTGGGAACTTTTGAAAACTATCAAGAGG
CTTGTTAGACAAATTTATATTCTGAAACCTCAATAAGAAAGCATTCCAGGTTTCAATCCTTGTTTTTTGTCCTGCTCCCAAATTCTTTTT
TAAACCCATAGTTCTTGTGTCTTATTTGATTCTTCTGCTGTGCACATTGTATTGGTCCTTGTTGCATGTAGTCTACTGTGTGTTTTCCGA
TTTTATAAGGCAGCATTTCTCCATACAAAAAGAAAAAAAATGATGTACATATAAACGCTTTTGTTGTATGGCTCCTCCATGTTACTGTAT
ATATCTGCCAGCACTTCCCAGTTACACTCCTGTGAGTCAGCTTATTTTTACCCTAACATAAATAGTATGTTTTGTAGTAGTTATCAAATT
TAAGAGATAAAGCAATCAGAATGTTTGGATTTTCTTCTATCTTAATGTGAATTTCATAATTAATGTCTATTTATTCAGCTATTCATTAAA

>55750_55750_3_MTMR2-MAML2_MTMR2_chr11_95598765_ENST00000352297_MAML2_chr11_95724887_ENST00000524717_length(amino acids)=415AA_BP=
MNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQA
LANPVSTHTILTPNSSLLSTSHGTRMPSLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNN
VATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSNTTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQ
RAVAPPNQLTPAVQMRPMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQGTD

--------------------------------------------------------------
>55750_55750_4_MTMR2-MAML2_MTMR2_chr11_95598765_ENST00000393223_MAML2_chr11_95724887_ENST00000524717_length(transcript)=4391nt_BP=709nt
AGATGTCGCGCGGCCGGACACAGCCAGCACGGAGAGTCGATGCCGGCGTCTGAGCTGCGCAGTGGGGTCTTCCCGCTGCCCAGCAGCCTA
CAGGCGCGGTGCACTCTGGGGGAACATGGCCGCTTCCGGTCTCCCTCCCGGGCCGGCGCTGGCCTGACTGCGGCCCCGGTCCGTAGCACT
CCGCCCTCCGCTTCTCCCGCCCTGTAGCCGCGAAGACTGCTTCAGCCTTTCCCTGTGCTGCCCCTGCCGCGCGATGGAGAAGAGCTCGAG
CTGCGAGAGTCTTGGCTCCCAGCCGGCGGCGGCTCGGCCGCCCAGCGTGGACTCCTTGTCCAGTTAATGTGTTAAGAGCCATTGACATTT
GAAGATCATCAGAAGTGAAGATAAAACATCTCAAAAATTATAATTGCCTCCACTTCTCATTCAGAGAATTCAGTGCATACAAAATCAGCT
TCTGTTGTATCATCAGATTCCATTTCAACTTCTGCCGACAACTTTTCTCCTGATTTGAGGAGGGAGTCTCGCTCTATCCCCTAGGCTGGA
GTGCATTGGCGCCATCTCGGCTCATTTGCAACCTCTGTCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCTTCCCGAGGAGCTGGGATTA
CAGGTCCTGAGGGAGTCTAACAAGTTAGCAGAAATGGAAGAACCACCCTTGCTTCCAGGAGAAAATATTAAAGACATGGGATCAACACTC
TGTGGTAGGCCAGAACACAGGCCCCAGTCCAAGTCCTAACCCCTGCTCAAATCCAAACACTGGAAGTGGTTACATGAACTCCCAGCAATC
ACTGTTGAATCAGCAATTGATGGGAAAGAAGCAGACTCTACAGAGGCAGATCATGGAGCAGAAACAGCAACTTCTTCTCCAGCAGCAGAT
GCTGGCTGACGCGGAGAAAATTGCTCCACAAGATCAGATAAACCGACATTTGTCAAGGCCACCTCCAGATTATAAAGACCAAAGAAGAAA
TGTGGGCAATATGCAACCAACTGCTCAGTATTCTGGTGGCTCATCCACAATAAGCTTAAACTCTAACCAGGCTTTGGCAAACCCAGTTTC
AACACACACCATTTTAACTCCCAATTCCAGCCTCCTGTCTACTTCTCACGGGACAAGAATGCCATCATTATCTACAGCAGTTCAGAATAT
GGGGATGTATGGAAATCTGCCTTGTAATCAACCTAACACATACAGTGTCACTTCAGGAATGAATCAATTGACCCAACAGAGAAACCCAAA
GCAATTGTTAGCAAATCAAAACAACCCTATGATGCCACGGCCACCTACCTTAGGGCCAAGTAATAATAACAATGTAGCCACTTTTGGAGC
TGGATCTGTTGGTAATTCACAACAATTGAGACCAAATTTAACCCATAGTATGGCAAGCATGCCACCACAGAGAACATCAAACGTAATGAT
CACATCCAACACAACTGCACCAAACTGGGCCTCTCAAGAAGGAACAAGCAAACAGCAAGAAGCCCTGACGTCTGCAGGAGTCCGCTTCCC
CACAGGTACACCTGCAGCCTATACCCCAAATCAGTCACTGCAACAGGCAGTAGGTAGCCAGCAATTTTCCCAGAGGGCAGTGGCTCCTCC
TAACCAGTTAACACCAGCAGTGCAAATGAGACCCATGAACCAAATGAGCCAAACACTAAATGGGCAAACCATGGGTCCCCTCAGGGGTCT
GAATCTCAGACCCAATCAGCTAAGCACACAGATTTTGCCTAATTTGAATCAGTCAGGAACAGGGTTGAATCAGTCGAGGACGGGCATCAA
CCAGCCACCATCCCTGACGCCCAGCAATTTTCCTTCACCCAACCAAAGTTCCAGGGCTTTTCAAGGAACTGACCACAGCAGTGACTTAGC
TTTTGACTTCCTCAGCCAACAAAATGATAACATGGGCCCTGCCCTAAACAGTGATGCTGATTTCATTGATTCTTTATTGAAGACAGAGCC
TGGTAATGATGACTGGATGAAAGACATCAATCTTGATGAAATCTTGGGGAACAATTCCTAAAGAAGAAAGGGAAGACAATTTACAAACTC
CAAGCACTAAAAGGCAGTATATTACAGAAACTCTGTAGAGGCTGAACTGTTGATGTTCAGGTGGACTACATGAAGATAACATGCTTAAAA
ATGGAAAGCAGAAAGTAACTGCAGTGATGAACATTTTGGTCCAAATTCTTGTTTTAAATCTTACACCTGAAAGTAAAATATTGGGATCAC
TTTTCCCTGTCTAAACTCCAGGATACAGTATCCAATTTATCCAAACAGAACTGTGGTGTCAATGTGTAATTAATTGTGTAAAATAGCCTT
CCCAAGTTTCTTTTTCCCTGGAAAATAAAAAAGGTAATAGAACTTGTAGTTTATTTAAACCCCATGTCATGAGGAGGTACTAGTTCCAAG
CAACAAACTCCTTAATTTGCTCTAATAGATAGGTATGGTTTAATCTTTCCATTGTGTCTTTTCATTTAATTTTCCTGAAGCTTGCAGGAT
AGATTGAAATGTTATAGGTTTGTTTGGAGTAACCAAACAGTATGCAAATTAAGAAAAAGCCAGAGAACCTAGAAAACATCCAGTGGATTA
CAGAATTTCTTCCCCATATTCACTCCTCACTTTTACAATTTTCCCACAATCCTCTACTTCAGTGGGATGCTGTGTCTAGTGATTAAACAA
AAATATAGAGCTGTGCAATTTGATTTTGGCTTCCACAACGAATATCTGAATCCATTCCAAATGAAATTTTAGATATAACAAAGACTTGTC
CTAATCATACTGAAATATTGGTGCACACCTCTCTGCATTAGATTTCACTTTTTTAAAAAACCCAGTGGACATTGCTATAAATAAGATTTA
TTTGGCTACAAATAACCTGGGATGTTGCTTATTATGATTGATGCCTGCTGGTTTGTTCCCAAGCTGAGTGAAATTGAACCTCGTCCTCCC
TACTCATTTTGATGACTGAGGCTGGTTTATAAGAAAAGGAAGTTTGGAGAAGAAAACCGAGATTAGAAAATATCATGTTTTGGTTGGAGA
TAAGAACCAGGGATGGCAAGTACCAGTGTGTACAAATGTATTTCACGGAGTTTGAAGGAACGCATAATCAAGAGGGAAAACAATTTGTCC
TTCATTGGACGTATTATTTGGATTTGGGTGAGCAACAAAATGGAATGTGGTCTGTTAGGAGCATTCTGTTTGTTCTTTTGTCCCTGATGT
GATGAATCATTGCCACATGCTAGATGGACTCTTCATATCCAGGTTTTGTCCCTCAGGGCTGAGCACTGTATTAAAGAGTTTTTGTTGAGT
CATTTAACCTTAGTGTCCACATCCAGATCAGCTGTAAAATGGGGAAGACGTGTGCTGATTTGGAATGAATGCAAAATATCACTATCATTT
TCCTAATTACAGAGGAGCAAAGGTTATCTTCAGCCCTTTCAGTTCTATGCTCACATATTCAAATATCAAATGTAATTTAGCTGAAGTTAT
TTAATAATCAAGTCTTTCAATATCTGTTCAAAGAAAAAGAACACACTTTGAAAATTCTGCAAAGCTGTCTCCCAGTCTTTAAAATGTCTG
GAAGCACTCTCCTTCTTTACAATACCAACATCACTGGCCCAGAATCTTCCCTGTGCTAGTTTGTAAATATAAATAAATTACTTGTTTTGT
AAACTTTTGTAAAGAATATTTTGGTAGAAATACTTCAAACATATTCTTTGGGTTATATTTATACATATGTGAAATAAATATACTATCAAA
AGGTTATATTTTATACAAAAAGTAAATTGCTACCTTTTGTATGCTAATATGCAAAGTTTTGTATAATATGATGGTTTATTTTTAGCTCTA
CACTTAAACCATAGGTGGTTGAGTGGGAACTTTTGAAAACTATCAAGAGGCTTGTTAGACAAATTTATATTCTGAAACCTCAATAAGAAA
GCATTCCAGGTTTCAATCCTTGTTTTTTGTCCTGCTCCCAAATTCTTTTTTAAACCCATAGTTCTTGTGTCTTATTTGATTCTTCTGCTG
TGCACATTGTATTGGTCCTTGTTGCATGTAGTCTACTGTGTGTTTTCCGATTTTATAAGGCAGCATTTCTCCATACAAAAAGAAAAAAAA
TGATGTACATATAAACGCTTTTGTTGTATGGCTCCTCCATGTTACTGTATATATCTGCCAGCACTTCCCAGTTACACTCCTGTGAGTCAG
CTTATTTTTACCCTAACATAAATAGTATGTTTTGTAGTAGTTATCAAATTTAAGAGATAAAGCAATCAGAATGTTTGGATTTTCTTCTAT

>55750_55750_4_MTMR2-MAML2_MTMR2_chr11_95598765_ENST00000393223_MAML2_chr11_95724887_ENST00000524717_length(amino acids)=415AA_BP=
MNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQA
LANPVSTHTILTPNSSLLSTSHGTRMPSLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNN
VATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSNTTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQ
RAVAPPNQLTPAVQMRPMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQGTD

--------------------------------------------------------------
>55750_55750_5_MTMR2-MAML2_MTMR2_chr11_95621320_ENST00000346299_MAML2_chr11_95826681_ENST00000524717_length(transcript)=5835nt_BP=527nt
CTCCTTCCATAAGGGTCTGGTCCTTCATCCCTCCCGCTTCACCAGACCCCCTCACCCTGGGAGCCGCCACCTCCCTTTCCCCAAGACCAG
ATGTCGCGCGGCCGGACACAGCCAGCACGGAGAGTCGATGCCGGCGTCTGAGCTGCGCAGTGGGGTCTTCCCGCTGCCCAGCAGCCTACA
GGCGCGGTGCACTCTGGGGGAACATGGCCGCTTCCGGTCTCCCTCCCGGGCCGGCGCTGGCCTGACTGCGGCCCCGGTCCGTAGCACTCC
GCCCTCCGCTTCTCCCGCCCTGTAGCCGCGAAGACTGCTTCAGCCTTTCCCTGTGCTGCCCCTGCCGCGCGATGGAGAAGAGCTCGAGCT
GCGAGAGTCTTGGCTCCCAGCCGGCGGCGGCTCGGCCGCCCAGCGTGGACTCCTTGTCCAGTGCCTCCACTTCTCATTCAGAGAATTCAG
TGCATACAAAATCAGCTTCTGTTGTATCATCAGATTCCATTTCAACTTCTGCCGACAACTTTTCTCCTGATTTGAGGCTCCAGGGTTCCT
TGAAAAGAAAACAGGTAGTTAACCTATCTCCTGCCAACAGCAAGCGACCCAATGGCTTTGTGGACAACTCATTTCTTGATATCAAAAGAA
TTCGTGTTGGGGAGAATCTCTCTGCAGGACAAGGTGGCCTCCAAATAAACAATGGACAAAGTCAGATTATGTCAGGGACCTTGCCTATGA
GCCAAGCACCCCTGCGAAAGACTAACACTCTGCCATCCCATACACATTCTCCTGGCAATGGCCTGTTTAACATGGGCTTAAAGGAGGTAA
AGAAGGAGCCAGGAGAGACTCTGTCTTGCAGTAAGCACATGGATGGCCAAATGACCCAAGAGAATATTTTTCCTAATAGGTACGGAGACG
ACCCTGGAGAACAACTGATGGATCCTGAGCTGCAGGAACTGTTCAATGAACTGACCAACATATCTGTGCCTCCCATGAGTGACCTTGAAC
TGGAGAACATGATCAATGCCACCATAAAGCAGGATGACCCATTTAACATTGACTTGGGTCAGCAAAGCCAGAGGAGCACACCTAGGCCCT
CCTTACCCATGGAGAAAATAGTGATCAAAAGTGAATACTCACCGGGCTTGACTCAGGGCCCCTCAGGCTCTCCTCAGCTGAGGCCCCCAT
CAGCTGGCCCCGCATTCTCCATGGCCAACTCTGCCCTCTCCACTTCGTCTCCAATCCCTTCAGTCCCTCAGAGCCAGGCTCAGCCTCAGA
CAGGCTCCGGAGCAAGCCGGGCCTTGCCAAGCTGGCAGGAAGTATCCCATGCCCAGCAGCTCAAACAGATAGCTGCTAATCGTCAGCAGC
ATGCCCGGATGCAGCAGCACCAGCAGCAGCACCAGCCTACCAACTGGTCAGCCTTGCCCTCTTCTGCTGGACCATCACCAGGTCCATTTG
GGCAGGAGAAAATCCCCAGCCCTTCTTTTGGTCAGCAGACATTCAGCCCACAGAGCTCCCCCATGCCTGGGGTAGCTGGCGGCAGCGGCC
AGTCGAAAGTAATGGCTAACTACATGTACAAGGCCGGCCCCTCAGCCCAGGGTGGGCACCTAGATGTCCTCATGCAGCAAAAGCCTCAGG
ATCTCAGTCGAAGTTTTATTAACAACCCGCACCCAGCCATGGAGCCCCGTCAGGGCAACACCAAGCCTTTGTTTCATTTTAACTCAGATC
AAGCGAACCAGCAGATGCCTTCTGTTTTGCCTTCCCAGAACAAGCCTTCTCTCCTACACTACACCCAACAGCAACAGCAGCAACAGCAGC
AGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAACAGCAACAGCAACAGCAACAGCAGAGTTCAATTTCAG
CTCAACAACAGCAACAGCAGCAGAGCTCAATTTCAGCCCAACAGCAGCAGCAGCAGCAACAACAGCAGCAGCAGCAGCAACAACAACAGC
AACAACAGCAGCAGCAGCAGCAGCAACAACCATCTTCTCAGCCTGCCCAATCTCTACCAAGCCAGCCTTTGCTAAGGTCACCTTTGCCAC
TTCAGCAAAAGCTCCTACTTCAGCAAATGCAGAATCAGCCCATTGCAGGAATGGGATACCAAGTCTCCCAACAACAGAGACAGGATCAAC
ACTCTGTGGTAGGCCAGAACACAGGCCCCAGTCCAAGTCCTAACCCCTGCTCAAATCCAAACACTGGAAGTGGTTACATGAACTCCCAGC
AATCACTGTTGAATCAGCAATTGATGGGAAAGAAGCAGACTCTACAGAGGCAGATCATGGAGCAGAAACAGCAACTTCTTCTCCAGCAGC
AGATGCTGGCTGACGCGGAGAAAATTGCTCCACAAGATCAGATAAACCGACATTTGTCAAGGCCACCTCCAGATTATAAAGACCAAAGAA
GAAATGTGGGCAATATGCAACCAACTGCTCAGTATTCTGGTGGCTCATCCACAATAAGCTTAAACTCTAACCAGGCTTTGGCAAACCCAG
TTTCAACACACACCATTTTAACTCCCAATTCCAGCCTCCTGTCTACTTCTCACGGGACAAGAATGCCATCATTATCTACAGCAGTTCAGA
ATATGGGGATGTATGGAAATCTGCCTTGTAATCAACCTAACACATACAGTGTCACTTCAGGAATGAATCAATTGACCCAACAGAGAAACC
CAAAGCAATTGTTAGCAAATCAAAACAACCCTATGATGCCACGGCCACCTACCTTAGGGCCAAGTAATAATAACAATGTAGCCACTTTTG
GAGCTGGATCTGTTGGTAATTCACAACAATTGAGACCAAATTTAACCCATAGTATGGCAAGCATGCCACCACAGAGAACATCAAACGTAA
TGATCACATCCAACACAACTGCACCAAACTGGGCCTCTCAAGAAGGAACAAGCAAACAGCAAGAAGCCCTGACGTCTGCAGGAGTCCGCT
TCCCCACAGGTACACCTGCAGCCTATACCCCAAATCAGTCACTGCAACAGGCAGTAGGTAGCCAGCAATTTTCCCAGAGGGCAGTGGCTC
CTCCTAACCAGTTAACACCAGCAGTGCAAATGAGACCCATGAACCAAATGAGCCAAACACTAAATGGGCAAACCATGGGTCCCCTCAGGG
GTCTGAATCTCAGACCCAATCAGCTAAGCACACAGATTTTGCCTAATTTGAATCAGTCAGGAACAGGGTTGAATCAGTCGAGGACGGGCA
TCAACCAGCCACCATCCCTGACGCCCAGCAATTTTCCTTCACCCAACCAAAGTTCCAGGGCTTTTCAAGGAACTGACCACAGCAGTGACT
TAGCTTTTGACTTCCTCAGCCAACAAAATGATAACATGGGCCCTGCCCTAAACAGTGATGCTGATTTCATTGATTCTTTATTGAAGACAG
AGCCTGGTAATGATGACTGGATGAAAGACATCAATCTTGATGAAATCTTGGGGAACAATTCCTAAAGAAGAAAGGGAAGACAATTTACAA
ACTCCAAGCACTAAAAGGCAGTATATTACAGAAACTCTGTAGAGGCTGAACTGTTGATGTTCAGGTGGACTACATGAAGATAACATGCTT
AAAAATGGAAAGCAGAAAGTAACTGCAGTGATGAACATTTTGGTCCAAATTCTTGTTTTAAATCTTACACCTGAAAGTAAAATATTGGGA
TCACTTTTCCCTGTCTAAACTCCAGGATACAGTATCCAATTTATCCAAACAGAACTGTGGTGTCAATGTGTAATTAATTGTGTAAAATAG
CCTTCCCAAGTTTCTTTTTCCCTGGAAAATAAAAAAGGTAATAGAACTTGTAGTTTATTTAAACCCCATGTCATGAGGAGGTACTAGTTC
CAAGCAACAAACTCCTTAATTTGCTCTAATAGATAGGTATGGTTTAATCTTTCCATTGTGTCTTTTCATTTAATTTTCCTGAAGCTTGCA
GGATAGATTGAAATGTTATAGGTTTGTTTGGAGTAACCAAACAGTATGCAAATTAAGAAAAAGCCAGAGAACCTAGAAAACATCCAGTGG
ATTACAGAATTTCTTCCCCATATTCACTCCTCACTTTTACAATTTTCCCACAATCCTCTACTTCAGTGGGATGCTGTGTCTAGTGATTAA
ACAAAAATATAGAGCTGTGCAATTTGATTTTGGCTTCCACAACGAATATCTGAATCCATTCCAAATGAAATTTTAGATATAACAAAGACT
TGTCCTAATCATACTGAAATATTGGTGCACACCTCTCTGCATTAGATTTCACTTTTTTAAAAAACCCAGTGGACATTGCTATAAATAAGA
TTTATTTGGCTACAAATAACCTGGGATGTTGCTTATTATGATTGATGCCTGCTGGTTTGTTCCCAAGCTGAGTGAAATTGAACCTCGTCC
TCCCTACTCATTTTGATGACTGAGGCTGGTTTATAAGAAAAGGAAGTTTGGAGAAGAAAACCGAGATTAGAAAATATCATGTTTTGGTTG
GAGATAAGAACCAGGGATGGCAAGTACCAGTGTGTACAAATGTATTTCACGGAGTTTGAAGGAACGCATAATCAAGAGGGAAAACAATTT
GTCCTTCATTGGACGTATTATTTGGATTTGGGTGAGCAACAAAATGGAATGTGGTCTGTTAGGAGCATTCTGTTTGTTCTTTTGTCCCTG
ATGTGATGAATCATTGCCACATGCTAGATGGACTCTTCATATCCAGGTTTTGTCCCTCAGGGCTGAGCACTGTATTAAAGAGTTTTTGTT
GAGTCATTTAACCTTAGTGTCCACATCCAGATCAGCTGTAAAATGGGGAAGACGTGTGCTGATTTGGAATGAATGCAAAATATCACTATC
ATTTTCCTAATTACAGAGGAGCAAAGGTTATCTTCAGCCCTTTCAGTTCTATGCTCACATATTCAAATATCAAATGTAATTTAGCTGAAG
TTATTTAATAATCAAGTCTTTCAATATCTGTTCAAAGAAAAAGAACACACTTTGAAAATTCTGCAAAGCTGTCTCCCAGTCTTTAAAATG
TCTGGAAGCACTCTCCTTCTTTACAATACCAACATCACTGGCCCAGAATCTTCCCTGTGCTAGTTTGTAAATATAAATAAATTACTTGTT
TTGTAAACTTTTGTAAAGAATATTTTGGTAGAAATACTTCAAACATATTCTTTGGGTTATATTTATACATATGTGAAATAAATATACTAT
CAAAAGGTTATATTTTATACAAAAAGTAAATTGCTACCTTTTGTATGCTAATATGCAAAGTTTTGTATAATATGATGGTTTATTTTTAGC
TCTACACTTAAACCATAGGTGGTTGAGTGGGAACTTTTGAAAACTATCAAGAGGCTTGTTAGACAAATTTATATTCTGAAACCTCAATAA
GAAAGCATTCCAGGTTTCAATCCTTGTTTTTTGTCCTGCTCCCAAATTCTTTTTTAAACCCATAGTTCTTGTGTCTTATTTGATTCTTCT
GCTGTGCACATTGTATTGGTCCTTGTTGCATGTAGTCTACTGTGTGTTTTCCGATTTTATAAGGCAGCATTTCTCCATACAAAAAGAAAA
AAAATGATGTACATATAAACGCTTTTGTTGTATGGCTCCTCCATGTTACTGTATATATCTGCCAGCACTTCCCAGTTACACTCCTGTGAG
TCAGCTTATTTTTACCCTAACATAAATAGTATGTTTTGTAGTAGTTATCAAATTTAAGAGATAAAGCAATCAGAATGTTTGGATTTTCTT

>55750_55750_5_MTMR2-MAML2_MTMR2_chr11_95621320_ENST00000346299_MAML2_chr11_95826681_ENST00000524717_length(amino acids)=1079AA_BP=94
MRPRSVALRPPLLPPCSREDCFSLSLCCPCRAMEKSSSCESLGSQPAAARPPSVDSLSSASTSHSENSVHTKSASVVSSDSISTSADNFS
PDLRLQGSLKRKQVVNLSPANSKRPNGFVDNSFLDIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPLRKTNTLPSHTHSPGNGL
FNMGLKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQLMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQ
SQRSTPRPSLPMEKIVIKSEYSPGLTQGPSGSPQLRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGASRALPSWQEVSHAQQLK
QIAANRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKIPSPSFGQQTFSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLD
VLMQQKPQDLSRSFINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ
QQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQV
SQQQRQDQHSVVGQNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRP
PPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLSTSHGTRMPSLSTAVQNMGMYGNLPCNQPNTYSVTSGM
NQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNNVATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSNTTAPNWASQEGTSKQQE
ALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQLTPAVQMRPMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MTMR2-MAML2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MTMR2-MAML2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MTMR2-MAML2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource