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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MTMR9-NECAB1 (FusionGDB2 ID:55802)

Fusion Gene Summary for MTMR9-NECAB1

Fusion gene summary

Fusion gene information	Fusion gene name: MTMR9-NECAB1
	Fusion gene ID: 55802
		Hgene	Tgene
	Gene symbol	MTMR9	NECAB1
	Gene ID	66036	64168
	Gene name	myotubularin related protein 9	N-terminal EF-hand calcium binding protein 1
	Synonyms	C8orf9\|LIP-STYX\|MTMR8	EFCBP1\|STIP-1
	Cytomap	8p23.1	8q21.3
	Type of gene	protein-coding	protein-coding
	Description	myotubularin-related protein 9inactive phosphatidylinositol 3-phosphatase 9myotubularin related protein 8	N-terminal EF-hand calcium-binding protein 1EF-hand calcium-binding protein 1neuronal calcium binding proteinneuronal calcium-binding protein 1synaptotagmin interacting protein 1
	Modification date	20200327	20200313
	UniProtAcc	Q96QG7	Q8N987
	Ensembl transtripts involved in fusion gene	ENST00000221086, ENST00000526292,	ENST00000521954, ENST00000521366, ENST00000522820, ENST00000417640,
Fusion gene scores	* DoF score	3 X 3 X 2=18	6 X 3 X 4=72
	# samples	3	6
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MTMR9 [Title/Abstract] AND NECAB1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MTMR9(11152811)-NECAB1(91813919), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MTMR9	GO:0010922	positive regulation of phosphatase activity	22647598
Hgene	MTMR9	GO:0050821	protein stabilization	22647598
Hgene	MTMR9	GO:0060304	regulation of phosphatidylinositol dephosphorylation	22647598

Fusion gene breakpoints across MTMR9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NECAB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8296-01A	MTMR9	chr8	11152811	+	NECAB1	chr8	91813919	+

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Fusion Gene ORF analysis for MTMR9-NECAB1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000221086	ENST00000521954	MTMR9	chr8	11152811	+	NECAB1	chr8	91813919	+
5CDS-3UTR	ENST00000526292	ENST00000521954	MTMR9	chr8	11152811	+	NECAB1	chr8	91813919	+
5CDS-intron	ENST00000221086	ENST00000521366	MTMR9	chr8	11152811	+	NECAB1	chr8	91813919	+
5CDS-intron	ENST00000221086	ENST00000522820	MTMR9	chr8	11152811	+	NECAB1	chr8	91813919	+
5CDS-intron	ENST00000526292	ENST00000521366	MTMR9	chr8	11152811	+	NECAB1	chr8	91813919	+
5CDS-intron	ENST00000526292	ENST00000522820	MTMR9	chr8	11152811	+	NECAB1	chr8	91813919	+
In-frame	ENST00000221086	ENST00000417640	MTMR9	chr8	11152811	+	NECAB1	chr8	91813919	+
In-frame	ENST00000526292	ENST00000417640	MTMR9	chr8	11152811	+	NECAB1	chr8	91813919	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000221086

MTMR9

chr8

11152811

ENST00000417640

NECAB1

chr8

91813919

5617

764

473

1720

415

ENST00000526292

MTMR9

chr8

11152811

ENST00000417640

NECAB1

chr8

91813919

5185

332

236

1288

350

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000221086	ENST00000417640	MTMR9	chr8	11152811	+	NECAB1	chr8	91813919	+	0.000273844	0.9997261
ENST00000526292	ENST00000417640	MTMR9	chr8	11152811	+	NECAB1	chr8	91813919	+	7.12E-05	0.9999287

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Fusion Genomic Features for MTMR9-NECAB1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MTMR9-NECAB1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:11152811/chr8:91813919)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MTMR9 Q96QG7	NECAB1 Q8N987
FUNCTION: Acts as an adapter for myotubularin-related phosphatases (PubMed:19038970, PubMed:22647598). Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate and MTMR6 binding affinity for phosphorylated phosphatidylinositols (PubMed:19038970, PubMed:22647598). Positively regulates lipid phosphatase MTMR7 catalytic activity (By similarity). Increases MTMR8 catalytic activity towards phosphatidylinositol 3-phosphate (PubMed:22647598). The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970). Stabilizes MTMR8 protein levels (PubMed:22647598). Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Negatively regulates autophagy, in part via its association with MTMR8 (PubMed:22647598). Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6 (PubMed:19038970, PubMed:22647598). Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine (PubMed:19038970). {ECO:0000250\|UniProtKB:Q9Z2D0, ECO:0000269\|PubMed:19038970, ECO:0000269\|PubMed:22647598, ECO:0000269\|PubMed:24591580}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MTMR9

chr8:11152811

chr8:91813919

ENST00000221086

4_99

550.0

Domain

GRAM

Tgene

NECAB1

chr8:11152811

chr8:91813919

ENST00000417640

39_50

352.0

Calcium binding

Tgene

NECAB1

chr8:11152811

chr8:91813919

ENST00000521366

39_50

101.0

Calcium binding

Tgene

NECAB1

chr8:11152811

chr8:91813919

ENST00000522820

39_50

101.0

Calcium binding

Tgene

NECAB1

chr8:11152811

chr8:91813919

ENST00000417640

135_163

352.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

NECAB1

chr8:11152811

chr8:91813919

ENST00000417640

209_275

352.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

NECAB1

chr8:11152811

chr8:91813919

ENST00000521366

135_163

101.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

NECAB1

chr8:11152811

chr8:91813919

ENST00000521366

209_275

101.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

NECAB1

chr8:11152811

chr8:91813919

ENST00000522820

135_163

101.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

NECAB1

chr8:11152811

chr8:91813919

ENST00000522820

209_275

101.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

NECAB1

chr8:11152811

chr8:91813919

ENST00000417640

252_340

352.0

Domain

Note=ABM

Tgene

NECAB1

chr8:11152811

chr8:91813919

ENST00000417640

60_95

352.0

Domain

EF-hand 2

Tgene

NECAB1

chr8:11152811

chr8:91813919

ENST00000521366

252_340

101.0

Domain

Note=ABM

Tgene

NECAB1

chr8:11152811

chr8:91813919

ENST00000521366

26_61

101.0

Domain

EF-hand 1

Tgene

NECAB1

chr8:11152811

chr8:91813919

ENST00000521366

60_95

101.0

Domain

EF-hand 2

Tgene

NECAB1

chr8:11152811

chr8:91813919

ENST00000522820

252_340

101.0

Domain

Note=ABM

Tgene

NECAB1

chr8:11152811

chr8:91813919

ENST00000522820

26_61

101.0

Domain

EF-hand 1

Tgene

NECAB1

chr8:11152811

chr8:91813919

ENST00000522820

60_95

101.0

Domain

EF-hand 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MTMR9

chr8:11152811

chr8:91813919

ENST00000221086

508_542

550.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

MTMR9

chr8:11152811

chr8:91813919

ENST00000221086

123_498

550.0

Domain

Myotubularin phosphatase

Tgene

NECAB1

chr8:11152811

chr8:91813919

ENST00000417640

26_61

352.0

Domain

EF-hand 1

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Fusion Gene Sequence for MTMR9-NECAB1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>55802_55802_1_MTMR9-NECAB1_MTMR9_chr8_11152811_ENST00000221086_NECAB1_chr8_91813919_ENST00000417640_length(transcript)=5617nt_BP=764nt
GTCTTCCGAGTTTCGAGACCTGCTGCTTCCGCCCGGAGTTGTTGTGGGCTCCAGCAGCGAGTAGCCACTTCCGCTAGGAGTCCCTAGCGG
CCAGGGCGTGGAAGCGGATTCTGAGGCGGCTTTCTCCTACTGCCCTCCGCTTGCCAACGCGGGACCCGGAGCCCAACGGCAGCGGCGGTC
CTTGGGCCTGTGGAGAGGGGTTCTCTGTGGCCGAGTCCTAGGCCTGGTGAACCGCGCGGTGCGGGAGAGGCGCTTGGGCCTCGTCCAGCC
CCAGCCCCTGTCTCCCCGCGGCCGGTGCCGGCGGCTGTAGGCCTCGCCGCGCCCACCCAGCCTGGGGCGGGCCCAGCCTCACCGCCCGGC
CCGCCCCGCCCCACGGGCCAGCCCCGCGCCGGGTGTTTCCGCTACTTCCCTGCGGCGGGGTAACCGCCTCGCACCTACCGGGCTCGGTTC
CCTGGCTCCGGCCGCGGGGGAGCATGGAGTTTGCGGAGCTGATTAAGACCCCGCGGGTGGACAATGTGGTGCTGCACCGGCCTTTCTACC
CGGCTGTCGAGGGCACCCTGTGCCTGACGGGCCACCACTTGATCCTGTCCTCCCGGCAGGACAATACGGAGGAGCTGTGGCTCCTCCATT
CAAACATCGACGCCATCGACAAGCGATTTGTAGGATCACTGGGTACCATCATCATAAAATGTAAAGATTTTCGAATTATTCAGTTGGATA
TTCCTGGAATGGAGGAATGCTTGAATATAGCCAGTTCCATTGAGATACTGAGGAGAGCAGACAAAAATGATGATGGAAAATTATCCTTTG
AAGAATTCAAAGCATATTTTGCAGATGGTGTTCTCAGTGGAGAAGAATTACACGAGCTTTTCCATACCATTGATACACATAATACTAATA
ATCTTGACACAGAAGAGCTATGTGAATATTTTTCTCAGCACTTGGGCGAGTATGAGAATGTACTAGCAGCACTTGAAGACCTGAATCTTT
CCATCCTGAAGGCAATGGGCAAAACAAAGAAAGACTACCAAGAAGCCTCCAATTTGGAACAATTCGTAACTAGATTTTTATTGAAGGAAA
CCCTGAATCAGCTGCAGTCTCTCCAGAATTCCCTGGAATGTGCCATGGAAACTACTGAGGAGCAAACCCGTCAAGAAAGGCAAGGGCCAG
CCAAGCCAGAAGTCCTGTCGATTCAATGGCCTGGAAAACGATCAAGCCGCCGAGTCCAGAGACACAACAGCTTCTCCCCAAACAGCCCTC
AGTTTAATGTCAGCGGTCCAGGCTTATTAGAAGAAGACAACCAGTGGATGACCCAGATAAATAGACTCCAGAAATTAATTGATAGACTGG
AAAAGAAGGATCTCAAACTCGAACCACCAGAAGAAGAAATTATTGAAGGGAATACTAAATCTCACATCATGCTTGTGCAGCGGCAGATGT
CTGTGATAGAAGAGGACCTGGAAGAATTCCAGCTCGCTCTGAAACACTACGTGGAGAGTGCTTCCTCCCAAAGTGGATGCTTGCGTATTT
CTATACAGAAGCTTTCAAATGAATCTCGCTACATGATCTATGAGTTCTGGGAGAATAGTAGTGTATGGAATAGCCACCTTCAGACAAATT
ATAGCAAGACATTCCAAAGAAGTAATGTGGATTTCTTGGAAACTCCAGAACTCACATCTACAATGCTAGTTCCTGCTTCGTGGTGGATCC
TGAACAACTAGATGTTCCTAGACATTTTCTTTATGGTTCCAAGTGCAAAACAGGTGTTCTTATCTAAAACGTCAATTAGAAAATTATCTG
CGGTTGTTAATCTACTGTATATTTTTGTTTGGTATATTTACTAAGTGCACTCTTTCAAAACTTATTCTATAACTTTATCAATTCATGTGA
ATTTTAGCTCAATTTTCAAAGTTCACTAATATTCTCAATATTTAATGCTAAATGCTTTGCTACATTGTAACTCACCTAAAACCTTTTAGT
GACAAAATCCTAATATGTGGAAAAAAGCATATGCATAAAGGAATAATATTGTGAAAATGAATCTGTTATGATAAAGAAAAAATAAAGTGG
AAACTTTTAGAGTATTACTTCATAGGGCAGATTTTGTAAACTGTCGTATACTGTAAAGGGTTAAATCAGCGTTTTGTGATTTTTAAGTAA
CTGTGAGTGAAGTTTATTCTTCAACAATGTCTACTCCATCCCCAACCCAACTCACAGCCCTATGACTACTATCTTTGCATTAGTTAAAAA
GTTAGTATATAGGCATCAAACAACCTTGGCTGTAACCTATAGAATCTCTATCCACGTATCAGGTTATAGACTGGTTTTTCAAAAGTGAAC
AATCCTGTGATAAGTTGGAGTACCATTTAGTAATACAGCAACATTGTGTCATTTATTAGCATCATAATTCTTTGTTATGTAAGTTAAATA
TATCAAGAAAGAAGAGACTGTTTGGAAAAATGTGGTTCAAGTTTTATGCTATATAGTTTTGGTATGCGATACAGACAGCTAACTTTTCTT
ATGAAAAATACATATTTGCATGTAAACAATGATTTCAAAATACTTGAAAAATAAAATTTTAACCCAAATGAATAACTAAGAAATATAAAA
CAAGCACAAAATCTTAGGGAAGTCATAAAATAGTAGTGAAAGTATTAGACAGAAGACATCTGTTTTCGAATTTCAACACTAGAATGACTA
AAACTATCTACCTATAGAACTATCTGTAGATAGTATACTATCTACACTCTGCTCAACAAGCTCAGAAATTAAATATTTTTAATAATAAAA
ATCTGTTCTGGTTATAAACCTTGCTAATGAAAATACAATACATATAAAAATGTATAGCCATGTTATTTTCTAGTATAAATTCCTTTGAAA
CTATAAGTCTTTGAGGAAAATTATAAGGTAAAATTTTCCTGTTTTTCCCCCTTTGAAAAACTCAGGAAAAAAGGAAGATTGAACTAATAA
AATTTTATTTCTTAAATATAAATTTGACCTAAAATATTTTCTCAAACTAATTCATGAAACAGCAACTTTTACCAATACCTTTGTATACTC
TCAGTTCTCATTCAGTATAAATAAAATTTTAAAATCCTTTCATAGTTCTATTAGAAATAAGTAGTAAATTTTGATATATTGTACATACAC
ACGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTGTGTGCCTCTGGTCAACTCTAAGGATGACAGACACTGTGTAA
CAACACCTGGGTCAACTCTTTTAATTTATATACAAAGCAAAGAACAACATTAATGGAGATGCACAATGATTATTCAAACAAGCTATATAT
ATGTACAAAGGCAAACAGACACATAACAGTCTCTGCAGACTGATTGTATATAGTAAGAAAAGATCAAAAGACTTTAAAACCTAAATGACT
TTTGACATACAAACTCTTCTTGAGAATGTTTGTTGTAAATGGTTTCAAAAATACAAATTATAGCCAATCAAAACATTGCTTTGGTTGGTG
CATTTAAGTATCCAACTCAAAAAGCATATCAAATATTTTGGGTACTAGGCAGTTTCCAAAGTAGCATGGTAGTATTACTTGTTAAAAGGG
TTCTGTTTTCATTAACAGTACTAAGTGGAAGGGATCTGCAGATTCCAAACTGGAATAAGCTCTATCATATTCTGAAACAAGAATTAGAAT
GACTTGAGAACGGGCAAATAACAAAGCAAACCAATATAATTATATGGTCATTCTGACCCCAGCTCTTATACAAATTATACATGTATTTTT
GTGTATGTTTGTGAGAGTTGTATGTATGTGAATGTGTGTGAGTGTGTATTCACATACACATATATACTGGAACCTATAGTAGAAAAGGAA
ACTAGTAGGGCCAAAAAAAAAAAGAAAAAGAAAAAGAAAAAAGAAAAAAAAAGAAAAAACTGGGACCTAAGTATAAATATCTCATCCTAA
AGTAAACAATAAGTTTATAGTTAACGAAGATTTTTTTCTATTTAAAACCCCATTTTCCTAAAGAACAAAGTAGTAAAATAAAAAAAAATT
TAAAAAATTAAAAAATAAAAAAAAGAGGTCACTAAAAGACCAAGATGGGAAACGTAACATGGAATACAAGCTTGAATCTGGGAAACAAGC
TCAAAAAACAGTGAAAAAAAAAGTACTGGTTTAGGAGTTCAAAATTCAGTGAAACAAACTTTTTGCCAATAGACCTAGGGATCTAAGAAA
TAGAATTAGGGAGAGTTTACACTTACTTACCTATATATCAGCAGATTTTTCTGGAAGAAACCCTTTTTTTTTTTTTTTTTAAACAGTAAC
ATCCAGAGTGACAAATTGCAGGAGATTTAATGTATAAAATTTCTAGGAATTAAAAGCTTAAACCCAAAAATTGTTCATCCATATATAAGA
AATTATCGAATTAAAACTTAATGTATGTCAATTATTTTCAAATGTCTAAATTCCTTTGGAAATAAAAATATCAGTTTTACTTTGAAATTG
CTCAACTTCTGCTATTCATATGGTCTGATTAGTGACATAAGTAGCAGCCGTTTTTCAACTTCAGTTTCATTCACTACCATTGTTTCCAAA
TTATCAATCTCTGCTAGTAATTATGAATTTAAGACCATATTATTATCAAAAACCTAGAGACCAATCATATATCTGAAAAGAAATACCCAT
TAAAAATTCTGCCTCCTGTTTATTGAGAACTATGCATTGAACATTCTGAATCATTCTAAGCCTCTGGAGAGACTGTAATGATCCATTCAT
GAGCTGGTATGAAATCAGTGGGAAGCAGAACAACAGAAGGAACTTTAAAAGCAACAAGCAATTATGTACCATATATACACTGTAGCAAAT
ATTTTATATTTGAGAGTCTTTACAGCTTACATTTCCATTCCATTATTACAAGTGATGAAAAACAAAAAATTGCAAGTAGTATGCAAATTA
TAAATATACAGTCTTCCCACTTCACTAACCAAATTCCTACTTTCCAGTGTTACTTCCCAATTTATGCAGGAAACCTCCTGCAAAGCTGAA
ACTGATTAGAAAATTCTTTATATTTTAAAATAGCTCTTTCTCATTTTTAGAGAAGTCAAATAGCCAACCATCAAAATTAAGAATAAATTG
AATTGTCACAGTCCATTACAGTTATTGTTGCTAGATCCACCTCATTTGCAGATGTCCAAACTTAAATTCATCTGTTCTTAAAATGCTACT
TAAAACTTTGGTTGTTTTCCTGTAATATAAAAGAAAAAGTTAATTTATCAATTGATTGAATACAGTTTTTACTAATTAGTTTATCAAACC
AAATACTGTGAACGTACCAGGTGTTTACAGATTTAAATGCATGTTACCATAGAAACTATTAAAGTAACTAGAACTGTCAAATAACAAAAC
GGCTCATGTTTTTAAAATATATGTAACTCATTTTAAAATATATTAAATTGTATTCCAAACCTGTTCTTCTGTTTCTGTGGCACCTAGGTT
TAAAATATGTATTAATGTGTAAATCACAAGTAAAATGAATTCTAATGTACAAGTTTGTTTTAAAAAGTGTATGTCAAGCTTTTATTTACA

>55802_55802_1_MTMR9-NECAB1_MTMR9_chr8_11152811_ENST00000221086_NECAB1_chr8_91813919_ENST00000417640_length(amino acids)=415AA_BP=97
MEFAELIKTPRVDNVVLHRPFYPAVEGTLCLTGHHLILSSRQDNTEELWLLHSNIDAIDKRFVGSLGTIIIKCKDFRIIQLDIPGMEECL
NIASSIEILRRADKNDDGKLSFEEFKAYFADGVLSGEELHELFHTIDTHNTNNLDTEELCEYFSQHLGEYENVLAALEDLNLSILKAMGK
TKKDYQEASNLEQFVTRFLLKETLNQLQSLQNSLECAMETTEEQTRQERQGPAKPEVLSIQWPGKRSSRRVQRHNSFSPNSPQFNVSGPG
LLEEDNQWMTQINRLQKLIDRLEKKDLKLEPPEEEIIEGNTKSHIMLVQRQMSVIEEDLEEFQLALKHYVESASSQSGCLRISIQKLSNE

--------------------------------------------------------------
>55802_55802_2_MTMR9-NECAB1_MTMR9_chr8_11152811_ENST00000526292_NECAB1_chr8_91813919_ENST00000417640_length(transcript)=5185nt_BP=332nt
TCCGCAGGGAGCCGGGGGTCCCTTGTGGGCGCCCCGGGAAATACTTCCTGGCGTTTTCCGCGCAGCCTGCCGCCCAGCTAGCCGGCAAGA
TGAGCCCTCTGTGGCCTAGAATCAGGATTTACCAAGCTGAAACCCGTCCAGATGGAGGACCCGGTTTCCATTAAACCTGGATGGAGTTCT
CAGGGTTATCGTGTGGCTGGTACCATCCTGATGATCATTTCTGATTTGTAGGATCACTGGGTACCATCATCATAAAATGTAAAGATTTTC
GAATTATTCAGTTGGATATTCCTGGAATGGAGGAATGCTTGAATATAGCCAGTTCCATTGAGATACTGAGGAGAGCAGACAAAAATGATG
ATGGAAAATTATCCTTTGAAGAATTCAAAGCATATTTTGCAGATGGTGTTCTCAGTGGAGAAGAATTACACGAGCTTTTCCATACCATTG
ATACACATAATACTAATAATCTTGACACAGAAGAGCTATGTGAATATTTTTCTCAGCACTTGGGCGAGTATGAGAATGTACTAGCAGCAC
TTGAAGACCTGAATCTTTCCATCCTGAAGGCAATGGGCAAAACAAAGAAAGACTACCAAGAAGCCTCCAATTTGGAACAATTCGTAACTA
GATTTTTATTGAAGGAAACCCTGAATCAGCTGCAGTCTCTCCAGAATTCCCTGGAATGTGCCATGGAAACTACTGAGGAGCAAACCCGTC
AAGAAAGGCAAGGGCCAGCCAAGCCAGAAGTCCTGTCGATTCAATGGCCTGGAAAACGATCAAGCCGCCGAGTCCAGAGACACAACAGCT
TCTCCCCAAACAGCCCTCAGTTTAATGTCAGCGGTCCAGGCTTATTAGAAGAAGACAACCAGTGGATGACCCAGATAAATAGACTCCAGA
AATTAATTGATAGACTGGAAAAGAAGGATCTCAAACTCGAACCACCAGAAGAAGAAATTATTGAAGGGAATACTAAATCTCACATCATGC
TTGTGCAGCGGCAGATGTCTGTGATAGAAGAGGACCTGGAAGAATTCCAGCTCGCTCTGAAACACTACGTGGAGAGTGCTTCCTCCCAAA
GTGGATGCTTGCGTATTTCTATACAGAAGCTTTCAAATGAATCTCGCTACATGATCTATGAGTTCTGGGAGAATAGTAGTGTATGGAATA
GCCACCTTCAGACAAATTATAGCAAGACATTCCAAAGAAGTAATGTGGATTTCTTGGAAACTCCAGAACTCACATCTACAATGCTAGTTC
CTGCTTCGTGGTGGATCCTGAACAACTAGATGTTCCTAGACATTTTCTTTATGGTTCCAAGTGCAAAACAGGTGTTCTTATCTAAAACGT
CAATTAGAAAATTATCTGCGGTTGTTAATCTACTGTATATTTTTGTTTGGTATATTTACTAAGTGCACTCTTTCAAAACTTATTCTATAA
CTTTATCAATTCATGTGAATTTTAGCTCAATTTTCAAAGTTCACTAATATTCTCAATATTTAATGCTAAATGCTTTGCTACATTGTAACT
CACCTAAAACCTTTTAGTGACAAAATCCTAATATGTGGAAAAAAGCATATGCATAAAGGAATAATATTGTGAAAATGAATCTGTTATGAT
AAAGAAAAAATAAAGTGGAAACTTTTAGAGTATTACTTCATAGGGCAGATTTTGTAAACTGTCGTATACTGTAAAGGGTTAAATCAGCGT
TTTGTGATTTTTAAGTAACTGTGAGTGAAGTTTATTCTTCAACAATGTCTACTCCATCCCCAACCCAACTCACAGCCCTATGACTACTAT
CTTTGCATTAGTTAAAAAGTTAGTATATAGGCATCAAACAACCTTGGCTGTAACCTATAGAATCTCTATCCACGTATCAGGTTATAGACT
GGTTTTTCAAAAGTGAACAATCCTGTGATAAGTTGGAGTACCATTTAGTAATACAGCAACATTGTGTCATTTATTAGCATCATAATTCTT
TGTTATGTAAGTTAAATATATCAAGAAAGAAGAGACTGTTTGGAAAAATGTGGTTCAAGTTTTATGCTATATAGTTTTGGTATGCGATAC
AGACAGCTAACTTTTCTTATGAAAAATACATATTTGCATGTAAACAATGATTTCAAAATACTTGAAAAATAAAATTTTAACCCAAATGAA
TAACTAAGAAATATAAAACAAGCACAAAATCTTAGGGAAGTCATAAAATAGTAGTGAAAGTATTAGACAGAAGACATCTGTTTTCGAATT
TCAACACTAGAATGACTAAAACTATCTACCTATAGAACTATCTGTAGATAGTATACTATCTACACTCTGCTCAACAAGCTCAGAAATTAA
ATATTTTTAATAATAAAAATCTGTTCTGGTTATAAACCTTGCTAATGAAAATACAATACATATAAAAATGTATAGCCATGTTATTTTCTA
GTATAAATTCCTTTGAAACTATAAGTCTTTGAGGAAAATTATAAGGTAAAATTTTCCTGTTTTTCCCCCTTTGAAAAACTCAGGAAAAAA
GGAAGATTGAACTAATAAAATTTTATTTCTTAAATATAAATTTGACCTAAAATATTTTCTCAAACTAATTCATGAAACAGCAACTTTTAC
CAATACCTTTGTATACTCTCAGTTCTCATTCAGTATAAATAAAATTTTAAAATCCTTTCATAGTTCTATTAGAAATAAGTAGTAAATTTT
GATATATTGTACATACACACGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTGTGTGCCTCTGGTCAACTCTAAGG
ATGACAGACACTGTGTAACAACACCTGGGTCAACTCTTTTAATTTATATACAAAGCAAAGAACAACATTAATGGAGATGCACAATGATTA
TTCAAACAAGCTATATATATGTACAAAGGCAAACAGACACATAACAGTCTCTGCAGACTGATTGTATATAGTAAGAAAAGATCAAAAGAC
TTTAAAACCTAAATGACTTTTGACATACAAACTCTTCTTGAGAATGTTTGTTGTAAATGGTTTCAAAAATACAAATTATAGCCAATCAAA
ACATTGCTTTGGTTGGTGCATTTAAGTATCCAACTCAAAAAGCATATCAAATATTTTGGGTACTAGGCAGTTTCCAAAGTAGCATGGTAG
TATTACTTGTTAAAAGGGTTCTGTTTTCATTAACAGTACTAAGTGGAAGGGATCTGCAGATTCCAAACTGGAATAAGCTCTATCATATTC
TGAAACAAGAATTAGAATGACTTGAGAACGGGCAAATAACAAAGCAAACCAATATAATTATATGGTCATTCTGACCCCAGCTCTTATACA
AATTATACATGTATTTTTGTGTATGTTTGTGAGAGTTGTATGTATGTGAATGTGTGTGAGTGTGTATTCACATACACATATATACTGGAA
CCTATAGTAGAAAAGGAAACTAGTAGGGCCAAAAAAAAAAAGAAAAAGAAAAAGAAAAAAGAAAAAAAAAGAAAAAACTGGGACCTAAGT
ATAAATATCTCATCCTAAAGTAAACAATAAGTTTATAGTTAACGAAGATTTTTTTCTATTTAAAACCCCATTTTCCTAAAGAACAAAGTA
GTAAAATAAAAAAAAATTTAAAAAATTAAAAAATAAAAAAAAGAGGTCACTAAAAGACCAAGATGGGAAACGTAACATGGAATACAAGCT
TGAATCTGGGAAACAAGCTCAAAAAACAGTGAAAAAAAAAGTACTGGTTTAGGAGTTCAAAATTCAGTGAAACAAACTTTTTGCCAATAG
ACCTAGGGATCTAAGAAATAGAATTAGGGAGAGTTTACACTTACTTACCTATATATCAGCAGATTTTTCTGGAAGAAACCCTTTTTTTTT
TTTTTTTTAAACAGTAACATCCAGAGTGACAAATTGCAGGAGATTTAATGTATAAAATTTCTAGGAATTAAAAGCTTAAACCCAAAAATT
GTTCATCCATATATAAGAAATTATCGAATTAAAACTTAATGTATGTCAATTATTTTCAAATGTCTAAATTCCTTTGGAAATAAAAATATC
AGTTTTACTTTGAAATTGCTCAACTTCTGCTATTCATATGGTCTGATTAGTGACATAAGTAGCAGCCGTTTTTCAACTTCAGTTTCATTC
ACTACCATTGTTTCCAAATTATCAATCTCTGCTAGTAATTATGAATTTAAGACCATATTATTATCAAAAACCTAGAGACCAATCATATAT
CTGAAAAGAAATACCCATTAAAAATTCTGCCTCCTGTTTATTGAGAACTATGCATTGAACATTCTGAATCATTCTAAGCCTCTGGAGAGA
CTGTAATGATCCATTCATGAGCTGGTATGAAATCAGTGGGAAGCAGAACAACAGAAGGAACTTTAAAAGCAACAAGCAATTATGTACCAT
ATATACACTGTAGCAAATATTTTATATTTGAGAGTCTTTACAGCTTACATTTCCATTCCATTATTACAAGTGATGAAAAACAAAAAATTG
CAAGTAGTATGCAAATTATAAATATACAGTCTTCCCACTTCACTAACCAAATTCCTACTTTCCAGTGTTACTTCCCAATTTATGCAGGAA
ACCTCCTGCAAAGCTGAAACTGATTAGAAAATTCTTTATATTTTAAAATAGCTCTTTCTCATTTTTAGAGAAGTCAAATAGCCAACCATC
AAAATTAAGAATAAATTGAATTGTCACAGTCCATTACAGTTATTGTTGCTAGATCCACCTCATTTGCAGATGTCCAAACTTAAATTCATC
TGTTCTTAAAATGCTACTTAAAACTTTGGTTGTTTTCCTGTAATATAAAAGAAAAAGTTAATTTATCAATTGATTGAATACAGTTTTTAC
TAATTAGTTTATCAAACCAAATACTGTGAACGTACCAGGTGTTTACAGATTTAAATGCATGTTACCATAGAAACTATTAAAGTAACTAGA
ACTGTCAAATAACAAAACGGCTCATGTTTTTAAAATATATGTAACTCATTTTAAAATATATTAAATTGTATTCCAAACCTGTTCTTCTGT
TTCTGTGGCACCTAGGTTTAAAATATGTATTAATGTGTAAATCACAAGTAAAATGAATTCTAATGTACAAGTTTGTTTTAAAAAGTGTAT

>55802_55802_2_MTMR9-NECAB1_MTMR9_chr8_11152811_ENST00000526292_NECAB1_chr8_91813919_ENST00000417640_length(amino acids)=350AA_BP=32
MGTIIIKCKDFRIIQLDIPGMEECLNIASSIEILRRADKNDDGKLSFEEFKAYFADGVLSGEELHELFHTIDTHNTNNLDTEELCEYFSQ
HLGEYENVLAALEDLNLSILKAMGKTKKDYQEASNLEQFVTRFLLKETLNQLQSLQNSLECAMETTEEQTRQERQGPAKPEVLSIQWPGK
RSSRRVQRHNSFSPNSPQFNVSGPGLLEEDNQWMTQINRLQKLIDRLEKKDLKLEPPEEEIIEGNTKSHIMLVQRQMSVIEEDLEEFQLA

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Top

Fusion Gene PPI Analysis for MTMR9-NECAB1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MTMR9-NECAB1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MTMR9-NECAB1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source