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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MTRR-NMD3 (FusionGDB2 ID:55903)

Fusion Gene Summary for MTRR-NMD3

check button Fusion gene summary
Fusion gene informationFusion gene name: MTRR-NMD3
Fusion gene ID: 55903
HgeneTgene
Gene symbol

MTRR

NMD3

Gene ID

4552

51068

Gene name5-methyltetrahydrofolate-homocysteine methyltransferase reductaseNMD3 ribosome export adaptor
SynonymsMSR|cblECGI-07
Cytomap

5p15.31

3q26.1

Type of geneprotein-codingprotein-coding
Descriptionmethionine synthase reductase[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing)methionine synthase reductase, mitochondrial60S ribosomal export protein NMD3NMD3 homologhNMD3
Modification date2020031520200313
UniProtAcc.

Q96D46

Ensembl transtripts involved in fusion geneENST00000264668, ENST00000440940, 
ENST00000341013, ENST00000502509, 
ENST00000478160, ENST00000351193, 
ENST00000460469, ENST00000472947, 
Fusion gene scores* DoF score3 X 2 X 3=184 X 4 X 4=64
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MTRR [Title/Abstract] AND NMD3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMTRR(7897360)-NMD3(160965046), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMTRR

GO:0009086

methionine biosynthetic process

11466310

HgeneMTRR

GO:0043418

homocysteine catabolic process

11466310

HgeneMTRR

GO:0046655

folic acid metabolic process

11466310

HgeneMTRR

GO:1904042

negative regulation of cystathionine beta-synthase activity

24416422


check buttonFusion gene breakpoints across MTRR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NMD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-66-2753-01AMTRRchr5

7897360

-NMD3chr3

160965046

+
ChimerDB4LUSCTCGA-66-2753-01AMTRRchr5

7897360

+NMD3chr3

160965046

+
ChimerDB4LUSCTCGA-66-2753MTRRchr5

7897360

+NMD3chr3

160965046

+


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Fusion Gene ORF analysis for MTRR-NMD3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000264668ENST00000478160MTRRchr5

7897360

+NMD3chr3

160965046

+
5CDS-intronENST00000440940ENST00000478160MTRRchr5

7897360

+NMD3chr3

160965046

+
In-frameENST00000264668ENST00000351193MTRRchr5

7897360

+NMD3chr3

160965046

+
In-frameENST00000264668ENST00000460469MTRRchr5

7897360

+NMD3chr3

160965046

+
In-frameENST00000264668ENST00000472947MTRRchr5

7897360

+NMD3chr3

160965046

+
In-frameENST00000440940ENST00000351193MTRRchr5

7897360

+NMD3chr3

160965046

+
In-frameENST00000440940ENST00000460469MTRRchr5

7897360

+NMD3chr3

160965046

+
In-frameENST00000440940ENST00000472947MTRRchr5

7897360

+NMD3chr3

160965046

+
intron-3CDSENST00000341013ENST00000351193MTRRchr5

7897360

+NMD3chr3

160965046

+
intron-3CDSENST00000341013ENST00000460469MTRRchr5

7897360

+NMD3chr3

160965046

+
intron-3CDSENST00000341013ENST00000472947MTRRchr5

7897360

+NMD3chr3

160965046

+
intron-3CDSENST00000502509ENST00000351193MTRRchr5

7897360

+NMD3chr3

160965046

+
intron-3CDSENST00000502509ENST00000460469MTRRchr5

7897360

+NMD3chr3

160965046

+
intron-3CDSENST00000502509ENST00000472947MTRRchr5

7897360

+NMD3chr3

160965046

+
intron-intronENST00000341013ENST00000478160MTRRchr5

7897360

+NMD3chr3

160965046

+
intron-intronENST00000502509ENST00000478160MTRRchr5

7897360

+NMD3chr3

160965046

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264668MTRRchr57897360+ENST00000351193NMD3chr3160965046+38422063302444804
ENST00000264668MTRRchr57897360+ENST00000472947NMD3chr3160965046+31892063302522830
ENST00000264668MTRRchr57897360+ENST00000460469NMD3chr3160965046+35392063302444804
ENST00000440940MTRRchr57897360+ENST00000351193NMD3chr3160965046+37832004132385790
ENST00000440940MTRRchr57897360+ENST00000472947NMD3chr3160965046+31302004132463816
ENST00000440940MTRRchr57897360+ENST00000460469NMD3chr3160965046+34802004132385790

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264668ENST00000351193MTRRchr57897360+NMD3chr3160965046+0.0001783430.9998217
ENST00000264668ENST00000472947MTRRchr57897360+NMD3chr3160965046+0.0004297770.9995702
ENST00000264668ENST00000460469MTRRchr57897360+NMD3chr3160965046+0.0002607310.9997392
ENST00000440940ENST00000351193MTRRchr57897360+NMD3chr3160965046+0.0001040130.99989593
ENST00000440940ENST00000472947MTRRchr57897360+NMD3chr3160965046+0.0002962020.9997038
ENST00000440940ENST00000460469MTRRchr57897360+NMD3chr3160965046+0.0001544160.9998455

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Fusion Genomic Features for MTRR-NMD3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MTRR-NMD3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:7897360/chr3:160965046)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NMD3

Q96D46

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. {ECO:0000269|PubMed:12724356, ECO:0000269|PubMed:12773398}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTRRchr5:7897360chr3:160965046ENST00000264668+1415271_533677726.0DomainFAD-binding FR-type
HgeneMTRRchr5:7897360chr3:160965046ENST00000264668+14155_147677726.0DomainFlavodoxin-like
HgeneMTRRchr5:7897360chr3:160965046ENST00000440940+1415271_533650699.0DomainFAD-binding FR-type
HgeneMTRRchr5:7897360chr3:160965046ENST00000440940+14155_147650699.0DomainFlavodoxin-like
HgeneMTRRchr5:7897360chr3:160965046ENST00000264668+1415487_490677726.0Nucleotide bindingFAD
HgeneMTRRchr5:7897360chr3:160965046ENST00000264668+1415610_611677726.0Nucleotide bindingNADP
HgeneMTRRchr5:7897360chr3:160965046ENST00000264668+1415624_626677726.0Nucleotide bindingNADP
HgeneMTRRchr5:7897360chr3:160965046ENST00000264668+141593_124677726.0Nucleotide bindingFMN
HgeneMTRRchr5:7897360chr3:160965046ENST00000440940+1415487_490650699.0Nucleotide bindingFAD
HgeneMTRRchr5:7897360chr3:160965046ENST00000440940+1415610_611650699.0Nucleotide bindingNADP
HgeneMTRRchr5:7897360chr3:160965046ENST00000440940+1415624_626650699.0Nucleotide bindingNADP
HgeneMTRRchr5:7897360chr3:160965046ENST00000440940+141593_124650699.0Nucleotide bindingFMN
HgeneMTRRchr5:7897360chr3:160965046ENST00000264668+1415166_247677726.0RegionNote=Hinge
HgeneMTRRchr5:7897360chr3:160965046ENST00000440940+1415166_247650699.0RegionNote=Hinge
TgeneNMD3chr5:7897360chr3:160965046ENST000003511931116405_422376504.0MotifNote=Nuclear and nucleolar localization signal
TgeneNMD3chr5:7897360chr3:160965046ENST000003511931116480_489376504.0MotifNote=Nuclear export signal
TgeneNMD3chr5:7897360chr3:160965046ENST000004604691015405_422376504.0MotifNote=Nuclear and nucleolar localization signal
TgeneNMD3chr5:7897360chr3:160965046ENST000004604691015480_489376504.0MotifNote=Nuclear export signal
TgeneNMD3chr5:7897360chr3:160965046ENST000003511931116425_503376504.0RegionNote=Necessary for the nuclear export of the 60S ribosomal subunit
TgeneNMD3chr5:7897360chr3:160965046ENST000004604691015425_503376504.0RegionNote=Necessary for the nuclear export of the 60S ribosomal subunit

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTRRchr5:7897360chr3:160965046ENST00000341013+18271_533058.333333333333336DomainFAD-binding FR-type
HgeneMTRRchr5:7897360chr3:160965046ENST00000341013+185_147058.333333333333336DomainFlavodoxin-like
HgeneMTRRchr5:7897360chr3:160965046ENST00000341013+18487_490058.333333333333336Nucleotide bindingFAD
HgeneMTRRchr5:7897360chr3:160965046ENST00000341013+18610_611058.333333333333336Nucleotide bindingNADP
HgeneMTRRchr5:7897360chr3:160965046ENST00000341013+18624_626058.333333333333336Nucleotide bindingNADP
HgeneMTRRchr5:7897360chr3:160965046ENST00000341013+1893_124058.333333333333336Nucleotide bindingFMN
HgeneMTRRchr5:7897360chr3:160965046ENST00000341013+18166_247058.333333333333336RegionNote=Hinge


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Fusion Gene Sequence for MTRR-NMD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>55903_55903_1_MTRR-NMD3_MTRR_chr5_7897360_ENST00000264668_NMD3_chr3_160965046_ENST00000351193_length(transcript)=3842nt_BP=2063nt
GGAGCTTTCTATTGGTCCTGGGTACCGAGCATGGGCGCTGCGTCAGTGCGCGCTGGCGCAAGGTTGGTGGAAGTCGCGTTGTGCAGTTTC
ACTGTTACATGCCTTGAAGTGATGAGGAGGTTTCTGTTACTATATGCTACACAGCAGGGACAGGCAAAGGCCATCGCAGAAGAAATATGT
GAGCAAGCTGTGGTACATGGATTTTCTGCAGATCTTCACTGTATTAGTGAATCCGATAAGTATGACCTAAAAACCGAAACAGCTCCTCTT
GTTGTTGTGGTTTCTACCACGGGCACCGGAGACCCACCCGACACAGCCCGCAAGTTTGTTAAGGAAATACAGAACCAAACACTGCCGGTT
GATTTCTTTGCTCACCTGCGGTATGGGTTACTGGGTCTCGGTGATTCAGAATACACCTACTTTTGCAATGGGGGGAAGATAATTGATAAA
CGACTTCAAGAGCTTGGAGCCCGGCATTTCTATGACACTGGACATGCAGATGACTGTGTAGGTTTAGAACTTGTGGTTGAGCCGTGGATT
GCTGGACTCTGGCCAGCCCTCAGAAAGCATTTTAGGTCAAGCAGAGGACAAGAGGAGATAAGTGGCGCACTCCCGGTGGCATCACCTGCA
TCCTCGAGGACAGACCTTGTGAAGTCAGAGCTGCTACACATTGAATCTCAAGTCGAGCTTCTGAGATTCGATGATTCAGGAAGAAAGGAT
TCTGAGGTTTTGAAGCAAAATGCAGTGAACAGCAACCAATCCAATGTTGTAATTGAAGACTTTGAGTCCTCACTTACCCGTTCGGTACCC
CCACTCTCACAAGCCTCTCTGAATATTCCTGGTTTACCCCCAGAATATTTACAGGTACATCTGCAGGAGTCTCTTGGCCAGGAGGAAAGC
CAAGTATCTGTGACTTCAGCAGATCCAGTTTTTCAAGTGCCAATTTCAAAGGCAGTTCAACTTACTACGAATGATGCCATAAAAACCACT
CTGCTGGTAGAATTGGACATTTCAAATACAGACTTTTCCTATCAGCCTGGAGATGCCTTCAGCGTGATCTGCCCTAACAGTGATTCTGAG
GTACAAAGCCTACTCCAAAGACTGCAGCTTGAAGATAAAAGAGAGCACTGCGTCCTTTTGAAAATAAAGGCAGACACAAAGAAGAAAGGA
GCTACCTTACCCCAGCATATACCTGCGGGATGTTCTCTCCAGTTCATTTTTACCTGGTGTCTTGAAATCCGAGCAATTCCTAAAAAGGCA
TTTTTGCGAGCCCTTGTGGACTATACCAGTGACAGTGCTGAAAAGCGCAGGCTACAGGAGCTGTGCAGTAAACAAGGGGCAGCCGATTAT
AGCCGCTTTGTACGAGATGCCTGTGCCTGCTTGTTGGATCTCCTCCTCGCTTTCCCTTCTTGCCAGCCACCACTCAGTCTCCTGCTCGAA
CATCTTCCTAAACTTCAACCCAGACCATATTCGTGTGCAAGCTCAAGTTTATTTCACCCAGGAAAGCTCCATTTTGTCTTCAACATTGTG
GAATTTCTGTCTACTGCCACAACAGAGGTTCTGCGGAAGGGAGTATGTACAGGCTGGCTGGCCTTGTTGGTTGCTTCAGTTCTTCAGCCA
AACATACATGCATCCCATGAAGACAGCGGGAAAGCCCTGGCTCCTAAGATATCCATCTCTCCTCGAACAACAAATTCTTTCCACTTACCA
GATGACCCCTCAATCCCCATCATAATGGTGGGTCCAGGAACCGGCATAGCCCCGTTTATTGGGTTCCTACAACATAGAGAGAAACTCCAA
GAACAACACCCAGATGGAAATTTTGGAGCAATGTGGTTGTTTTTTGGCTGCAGGCATAAGGATAGGGATTATCTATTCAGAAAAGAGCTC
AGACATTTCCTTAAGCATGGGATCTTAACTCATCTAAAGGTTTCCTTCTCAAGAGATGCTCCTGTTGGGGAGGAGGAAGCCCCAGCAAAG
TATGTGCAAGACAACATCCAGCTTCATGGCCAGCAGGTGGCGAGAATCCTCCTCCAGGAGAACGGCCATATTTATGTGTGTGGGTTTGAT
TTGGCCAACTGTAACTTAAATGATGAGCATGTCAACAAAATGAACTCAGATAGAGTTCCAGATGTGGTATTAATCAAGAAGAGCTATGAC
CGGACCAAACGTCAGCGTCGTAGAAACTGGAAATTGAAAGAGCTTGCAAGAGAGAGAGAAAACATGGATACAGATGATGAAAGGCAATAC
CAAGATTTTCTTGAAGATCTTGAAGAAGATGAGGCAATTCGAAAAAATGTCAACATTTACAGAGATTCAGCCATCCCTGTGGAAAGTGAC
ACCGATGATGAAGGAGCACCTCGAATTAGTCTGGCTGAGATGCTTGAAGACCTTCATATTTCCCAAGATGCCACTGGTGAAGAAGGTGCA
TCAATGCTGACATAATGAGATGTTGTAGACTGTTTCCATACATGGGCTTAAGAAGTTGGACAGAGTTACCTTAAGTGTCTCTACTATCTT
TGCCTCCAGATTTCAAGAGGAGAAATTTAGTTTTAAACCTGAATAAACATGTTTGTTTTCAGTGCTCACTCAAACCACTAAAACAGATGG
ATAGCTTTGAGGTTTTAGATAAGGAAAGATTATGGAGAATGTAGTTGTTATTGATTTTTGGCAATTTTACATTTGGAATTTTATCACTGT
GCTTTTTTATATGAGGCACTGTAGTATTTTCACATAGTATAGTACTCTGGATGTAAAAGCTCAAAAATTGTGATTCCTTGAACGTTCACT
AAATCTTCAAGCAAAAACACATTTTTACATTATTTTTACGTTGATTATTTTAGTGAAAGACCATATGAAGAAGCATTTTTAATATTAACT
TGTTACATACTTTGATCCACTTTACATCATTTTTATGTTGTTGAGGTAGGGAAATTAGGGTTCAGTTTATCACTGGACATTCAGGAGGCA
AGTCAATCTTTTTTATTTCCTTATAAAATTAACTCTTCAAAAGCCGTTAAACAGAGAGTTATCTTAATTTTTATTGCAGTAGGAGGAAAT
ATATTTAAAATATTTGTAGATTTATAGCAAATAGAGACTCGTTATTTAAAGGTTAAATAACAATTTGTTCTTTTGTTGTTTTTGCCAGTT
TAGGGCAGTAGCTGCTTTTGTCATAAATATCTTCCTACCACATCAAAAATGCTGCTTTTAAAATTTTTGTTTATAAATTGAGAAGGAATT
TTCTCTCTATAAGTTTCTGTCATTGAACAGATCACCATTAAAAAGAATATTAGAATCCAGCATGAAGATAATGGCTAATAAAAATGAGGT
ACATACTTTATAAAACCATTAATCAGATTTGAATGAGGAATGCTTCCCACATCCTTGAAAGAAAAACTGTGGCTTACGTTTTGAAGTATT
CTGAGAATGAAGTATTAAGATCCAATTTCTATAAGCAAGATCAGACTTGTTAAGTATGCCGCAAGTAAGAGCTAATTCATTCATTCCATG
TGTGCCACTAAATAAAGAGATTGAGCAAGTGCCACTGTGTGGAACATTTTTCTTTTTTTTAATATTGGACTTTCCAATTTTGAAATTATG
GATAAAGTCCTAAATTTTCTATAGTGGCTTCTTTTCTGTCTGCATATTTTGTTAAAATTGTGGATCTAAAAGCCATATCCTGTCTTTGGT
GGTGGCCTGGTAGGAATGGCTTGTCCTAGTTCTTCAAAGGTAAGATTGACCAAAGCAAGTTCTCATTGGTGGTCTGTGTTTACATCTTCC

>55903_55903_1_MTRR-NMD3_MTRR_chr5_7897360_ENST00000264668_NMD3_chr3_160965046_ENST00000351193_length(amino acids)=804AA_BP=678
MGAASVRAGARLVEVALCSFTVTCLEVMRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTG
DPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKH
FRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIP
GLPPEYLQVHLQESLGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQL
EDKREHCVLLKIKADTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDACAC
LLDLLLAFPSCQPPLSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSG
KALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILT
HLKVSFSRDAPVGEEEAPAKYVQDNIQLHGQQVARILLQENGHIYVCGFDLANCNLNDEHVNKMNSDRVPDVVLIKKSYDRTKRQRRRNW

--------------------------------------------------------------
>55903_55903_2_MTRR-NMD3_MTRR_chr5_7897360_ENST00000264668_NMD3_chr3_160965046_ENST00000460469_length(transcript)=3539nt_BP=2063nt
GGAGCTTTCTATTGGTCCTGGGTACCGAGCATGGGCGCTGCGTCAGTGCGCGCTGGCGCAAGGTTGGTGGAAGTCGCGTTGTGCAGTTTC
ACTGTTACATGCCTTGAAGTGATGAGGAGGTTTCTGTTACTATATGCTACACAGCAGGGACAGGCAAAGGCCATCGCAGAAGAAATATGT
GAGCAAGCTGTGGTACATGGATTTTCTGCAGATCTTCACTGTATTAGTGAATCCGATAAGTATGACCTAAAAACCGAAACAGCTCCTCTT
GTTGTTGTGGTTTCTACCACGGGCACCGGAGACCCACCCGACACAGCCCGCAAGTTTGTTAAGGAAATACAGAACCAAACACTGCCGGTT
GATTTCTTTGCTCACCTGCGGTATGGGTTACTGGGTCTCGGTGATTCAGAATACACCTACTTTTGCAATGGGGGGAAGATAATTGATAAA
CGACTTCAAGAGCTTGGAGCCCGGCATTTCTATGACACTGGACATGCAGATGACTGTGTAGGTTTAGAACTTGTGGTTGAGCCGTGGATT
GCTGGACTCTGGCCAGCCCTCAGAAAGCATTTTAGGTCAAGCAGAGGACAAGAGGAGATAAGTGGCGCACTCCCGGTGGCATCACCTGCA
TCCTCGAGGACAGACCTTGTGAAGTCAGAGCTGCTACACATTGAATCTCAAGTCGAGCTTCTGAGATTCGATGATTCAGGAAGAAAGGAT
TCTGAGGTTTTGAAGCAAAATGCAGTGAACAGCAACCAATCCAATGTTGTAATTGAAGACTTTGAGTCCTCACTTACCCGTTCGGTACCC
CCACTCTCACAAGCCTCTCTGAATATTCCTGGTTTACCCCCAGAATATTTACAGGTACATCTGCAGGAGTCTCTTGGCCAGGAGGAAAGC
CAAGTATCTGTGACTTCAGCAGATCCAGTTTTTCAAGTGCCAATTTCAAAGGCAGTTCAACTTACTACGAATGATGCCATAAAAACCACT
CTGCTGGTAGAATTGGACATTTCAAATACAGACTTTTCCTATCAGCCTGGAGATGCCTTCAGCGTGATCTGCCCTAACAGTGATTCTGAG
GTACAAAGCCTACTCCAAAGACTGCAGCTTGAAGATAAAAGAGAGCACTGCGTCCTTTTGAAAATAAAGGCAGACACAAAGAAGAAAGGA
GCTACCTTACCCCAGCATATACCTGCGGGATGTTCTCTCCAGTTCATTTTTACCTGGTGTCTTGAAATCCGAGCAATTCCTAAAAAGGCA
TTTTTGCGAGCCCTTGTGGACTATACCAGTGACAGTGCTGAAAAGCGCAGGCTACAGGAGCTGTGCAGTAAACAAGGGGCAGCCGATTAT
AGCCGCTTTGTACGAGATGCCTGTGCCTGCTTGTTGGATCTCCTCCTCGCTTTCCCTTCTTGCCAGCCACCACTCAGTCTCCTGCTCGAA
CATCTTCCTAAACTTCAACCCAGACCATATTCGTGTGCAAGCTCAAGTTTATTTCACCCAGGAAAGCTCCATTTTGTCTTCAACATTGTG
GAATTTCTGTCTACTGCCACAACAGAGGTTCTGCGGAAGGGAGTATGTACAGGCTGGCTGGCCTTGTTGGTTGCTTCAGTTCTTCAGCCA
AACATACATGCATCCCATGAAGACAGCGGGAAAGCCCTGGCTCCTAAGATATCCATCTCTCCTCGAACAACAAATTCTTTCCACTTACCA
GATGACCCCTCAATCCCCATCATAATGGTGGGTCCAGGAACCGGCATAGCCCCGTTTATTGGGTTCCTACAACATAGAGAGAAACTCCAA
GAACAACACCCAGATGGAAATTTTGGAGCAATGTGGTTGTTTTTTGGCTGCAGGCATAAGGATAGGGATTATCTATTCAGAAAAGAGCTC
AGACATTTCCTTAAGCATGGGATCTTAACTCATCTAAAGGTTTCCTTCTCAAGAGATGCTCCTGTTGGGGAGGAGGAAGCCCCAGCAAAG
TATGTGCAAGACAACATCCAGCTTCATGGCCAGCAGGTGGCGAGAATCCTCCTCCAGGAGAACGGCCATATTTATGTGTGTGGGTTTGAT
TTGGCCAACTGTAACTTAAATGATGAGCATGTCAACAAAATGAACTCAGATAGAGTTCCAGATGTGGTATTAATCAAGAAGAGCTATGAC
CGGACCAAACGTCAGCGTCGTAGAAACTGGAAATTGAAAGAGCTTGCAAGAGAGAGAGAAAACATGGATACAGATGATGAAAGGCAATAC
CAAGATTTTCTTGAAGATCTTGAAGAAGATGAGGCAATTCGAAAAAATGTCAACATTTACAGAGATTCAGCCATCCCTGTGGAAAGTGAC
ACCGATGATGAAGGAGCACCTCGAATTAGTCTGGCTGAGATGCTTGAAGACCTTCATATTTCCCAAGATGCCACTGGTGAAGAAGGTGCA
TCAATGCTGACATAATGAGATGTTGTAGACTGTTTCCATACATGGGCTTAAGAAGTTGGACAGAGTTACCTTAAGTGTCTCTACTATCTT
TGCCTCCAGATTTCAAGAGGAGAAATTTAGTTTTAAACCTGAATAAACATGTTTGTTTTCAGTGCTCACTCAAACCACTAAAACAGATGG
ATAGCTTTGAGGTTTTAGATAAGGAAAGATTATGGAGAATGTAGTTGTTATTGATTTTTGGCAATTTTACATTTGGAATTTTATCACTGT
GCTTTTTTATATGAGGCACTGTAGTATTTTCACATAGTATAGTACTCTGGATGTAAAAGCTCAAAAATTGTGATTCCTTGAACGTTCACT
AAATCTTCAAGCAAAAACACATTTTTACATTATTTTTACGTTGATTATTTTAGTGAAAGACCATATGAAGAAGCATTTTTAATATTAACT
TGTTACATACTTTGATCCACTTTACATCATTTTTATGTTGTTGAGGTAGGGAAATTAGGGTTCAGTTTATCACTGGACATTCAGGAGGCA
AGTCAATCTTTTTTATTTCCTTATAAAATTAACTCTTCAAAAGCCGTTAAACAGAGAGTTATCTTAATTTTTATTGCAGTAGGAGGAAAT
ATATTTAAAATATTTGTAGATTTATAGCAAATAGAGACTCGTTATTTAAAGGTTAAATAACAATTTGTTCTTTTGTTGTTTTTGCCAGTT
TAGGGCAGTAGCTGCTTTTGTCATAAATATCTTCCTACCACATCAAAAATGCTGCTTTTAAAATTTTTGTTTATAAATTGAGAAGGAATT
TTCTCTCTATAAGTTTCTGTCATTGAACAGATCACCATTAAAAAGAATATTAGAATCCAGCATGAAGATAATGGCTAATAAAAATGAGGT
ACATACTTTATAAAACCATTAATCAGATTTGAATGAGGAATGCTTCCCACATCCTTGAAAGAAAAACTGTGGCTTACGTTTTGAAGTATT
CTGAGAATGAAGTATTAAGATCCAATTTCTATAAGCAAGATCAGACTTGTTAAGTATGCCGCAAGTAAGAGCTAATTCATTCATTCCATG

>55903_55903_2_MTRR-NMD3_MTRR_chr5_7897360_ENST00000264668_NMD3_chr3_160965046_ENST00000460469_length(amino acids)=804AA_BP=678
MGAASVRAGARLVEVALCSFTVTCLEVMRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTG
DPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKH
FRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIP
GLPPEYLQVHLQESLGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQL
EDKREHCVLLKIKADTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDACAC
LLDLLLAFPSCQPPLSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSG
KALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILT
HLKVSFSRDAPVGEEEAPAKYVQDNIQLHGQQVARILLQENGHIYVCGFDLANCNLNDEHVNKMNSDRVPDVVLIKKSYDRTKRQRRRNW

--------------------------------------------------------------
>55903_55903_3_MTRR-NMD3_MTRR_chr5_7897360_ENST00000264668_NMD3_chr3_160965046_ENST00000472947_length(transcript)=3189nt_BP=2063nt
GGAGCTTTCTATTGGTCCTGGGTACCGAGCATGGGCGCTGCGTCAGTGCGCGCTGGCGCAAGGTTGGTGGAAGTCGCGTTGTGCAGTTTC
ACTGTTACATGCCTTGAAGTGATGAGGAGGTTTCTGTTACTATATGCTACACAGCAGGGACAGGCAAAGGCCATCGCAGAAGAAATATGT
GAGCAAGCTGTGGTACATGGATTTTCTGCAGATCTTCACTGTATTAGTGAATCCGATAAGTATGACCTAAAAACCGAAACAGCTCCTCTT
GTTGTTGTGGTTTCTACCACGGGCACCGGAGACCCACCCGACACAGCCCGCAAGTTTGTTAAGGAAATACAGAACCAAACACTGCCGGTT
GATTTCTTTGCTCACCTGCGGTATGGGTTACTGGGTCTCGGTGATTCAGAATACACCTACTTTTGCAATGGGGGGAAGATAATTGATAAA
CGACTTCAAGAGCTTGGAGCCCGGCATTTCTATGACACTGGACATGCAGATGACTGTGTAGGTTTAGAACTTGTGGTTGAGCCGTGGATT
GCTGGACTCTGGCCAGCCCTCAGAAAGCATTTTAGGTCAAGCAGAGGACAAGAGGAGATAAGTGGCGCACTCCCGGTGGCATCACCTGCA
TCCTCGAGGACAGACCTTGTGAAGTCAGAGCTGCTACACATTGAATCTCAAGTCGAGCTTCTGAGATTCGATGATTCAGGAAGAAAGGAT
TCTGAGGTTTTGAAGCAAAATGCAGTGAACAGCAACCAATCCAATGTTGTAATTGAAGACTTTGAGTCCTCACTTACCCGTTCGGTACCC
CCACTCTCACAAGCCTCTCTGAATATTCCTGGTTTACCCCCAGAATATTTACAGGTACATCTGCAGGAGTCTCTTGGCCAGGAGGAAAGC
CAAGTATCTGTGACTTCAGCAGATCCAGTTTTTCAAGTGCCAATTTCAAAGGCAGTTCAACTTACTACGAATGATGCCATAAAAACCACT
CTGCTGGTAGAATTGGACATTTCAAATACAGACTTTTCCTATCAGCCTGGAGATGCCTTCAGCGTGATCTGCCCTAACAGTGATTCTGAG
GTACAAAGCCTACTCCAAAGACTGCAGCTTGAAGATAAAAGAGAGCACTGCGTCCTTTTGAAAATAAAGGCAGACACAAAGAAGAAAGGA
GCTACCTTACCCCAGCATATACCTGCGGGATGTTCTCTCCAGTTCATTTTTACCTGGTGTCTTGAAATCCGAGCAATTCCTAAAAAGGCA
TTTTTGCGAGCCCTTGTGGACTATACCAGTGACAGTGCTGAAAAGCGCAGGCTACAGGAGCTGTGCAGTAAACAAGGGGCAGCCGATTAT
AGCCGCTTTGTACGAGATGCCTGTGCCTGCTTGTTGGATCTCCTCCTCGCTTTCCCTTCTTGCCAGCCACCACTCAGTCTCCTGCTCGAA
CATCTTCCTAAACTTCAACCCAGACCATATTCGTGTGCAAGCTCAAGTTTATTTCACCCAGGAAAGCTCCATTTTGTCTTCAACATTGTG
GAATTTCTGTCTACTGCCACAACAGAGGTTCTGCGGAAGGGAGTATGTACAGGCTGGCTGGCCTTGTTGGTTGCTTCAGTTCTTCAGCCA
AACATACATGCATCCCATGAAGACAGCGGGAAAGCCCTGGCTCCTAAGATATCCATCTCTCCTCGAACAACAAATTCTTTCCACTTACCA
GATGACCCCTCAATCCCCATCATAATGGTGGGTCCAGGAACCGGCATAGCCCCGTTTATTGGGTTCCTACAACATAGAGAGAAACTCCAA
GAACAACACCCAGATGGAAATTTTGGAGCAATGTGGTTGTTTTTTGGCTGCAGGCATAAGGATAGGGATTATCTATTCAGAAAAGAGCTC
AGACATTTCCTTAAGCATGGGATCTTAACTCATCTAAAGGTTTCCTTCTCAAGAGATGCTCCTGTTGGGGAGGAGGAAGCCCCAGCAAAG
TATGTGCAAGACAACATCCAGCTTCATGGCCAGCAGGTGGCGAGAATCCTCCTCCAGGAGAACGGCCATATTTATGTGTGTGGGTTTGAT
TTGGCCAACTGTAACTTAAATGATGAGCATGTCAACAAAATGAACTCAGATAGAGTTCCAGATGTGGTATTAATCAAGAAGAGCTATGAC
CGGACCAAACGTCAGCGTCGTAGAAACTGGAAATTGAAAGAGCTTGCAAGAGAGAGAGAAAACATGGATACAGATGATGAAAGGCAATAC
CAAGATTTTCTTGAAGATCTTGAAGAAGATGAGGCAATTCGAAAAAATGTCAACATTTACAGAGATTCAGCCATCCCTGTGGAAAGTGAC
ACCGATGATGAAGGAGCACCTCGAATTAGTCTGGCTGAGATGCTTGAAGACCTTCATATTTCCCAAGATGCCACTGGTGAAGAAGCCAAA
TCTGCACCTGAAGCTGCTGATTTAGAGTCAGAAGTCACTGAGGGGCCAAGTGTGGTGGTTGACGCCTGTAATCCCAGCACTTTGGGAGGC
TGAGGAGGGCAGATCACTTCAGGCCAGGAGTTCAAGACCAGCCTGGCCAACATAGTGAAACCCTGTCTCTACTAAAAATGCAAAAATTAT
CCGGGCGTGGTGGTGCACACATAGTCCCAGCTACTCGGGACGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAG
TCGAGATCTGGCCACTGTACTCCAGCCTGGGCGACAGAGTGAGACTCTGTTCCCCCACTCCCCCAATAAAAAAAGTCTGATGAGCAAGAA
AAGTTCAGGGGTAGAGTTGCTTGTGTAATTGAGATGTTTAACAGCATCAGGCTAATTCCTTGCCATAGTAGAACCCAGAAGCTCTGAGCT
GTGTGCCAGGAGATACCTCCCTGGTCAGTACTTAGTACCAGAGTTTTCCCTAGATTCTTTAATTTTAGTAAATGTGCTCACATTGAGTCA
ATCCTTACATAACTGGGTATGTTATTTCCAGCCCAAGGAATGTTTATTTTTAAAAATATTTTTAATTATCCATAATTTCAGACTTACAAA
ATGTCGCAAGTATTCCCGGATACCATTTACCTAGATTTGCCAAATGTAAACAATTTGCCTCATTTGCTTTCTTTCCCCTTCTCACTAATA

>55903_55903_3_MTRR-NMD3_MTRR_chr5_7897360_ENST00000264668_NMD3_chr3_160965046_ENST00000472947_length(amino acids)=830AA_BP=678
MGAASVRAGARLVEVALCSFTVTCLEVMRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTG
DPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKH
FRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIP
GLPPEYLQVHLQESLGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQL
EDKREHCVLLKIKADTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDACAC
LLDLLLAFPSCQPPLSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSG
KALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILT
HLKVSFSRDAPVGEEEAPAKYVQDNIQLHGQQVARILLQENGHIYVCGFDLANCNLNDEHVNKMNSDRVPDVVLIKKSYDRTKRQRRRNW
KLKELARERENMDTDDERQYQDFLEDLEEDEAIRKNVNIYRDSAIPVESDTDDEGAPRISLAEMLEDLHISQDATGEEAKSAPEAADLES

--------------------------------------------------------------
>55903_55903_4_MTRR-NMD3_MTRR_chr5_7897360_ENST00000440940_NMD3_chr3_160965046_ENST00000351193_length(transcript)=3783nt_BP=2004nt
GGTTCGTGCCCGGCTGGCGCGGCGTGGTTTCACTGTTACATGCCTTGAAGTGATGAGGAGGTTTCTGTTACTATATGCTACACAGCAGGG
ACAGGCAAAGGCCATCGCAGAAGAAATATGTGAGCAAGCTGTGGTACATGGATTTTCTGCAGATCTTCACTGTATTAGTGAATCCGATAA
GTATGACCTAAAAACCGAAACAGCTCCTCTTGTTGTTGTGGTTTCTACCACGGGCACCGGAGACCCACCCGACACAGCCCGCAAGTTTGT
TAAGGAAATACAGAACCAAACACTGCCGGTTGATTTCTTTGCTCACCTGCGGTATGGGTTACTGGGTCTCGGTGATTCAGAATACACCTA
CTTTTGCAATGGGGGGAAGATAATTGATAAACGACTTCAAGAGCTTGGAGCCCGGCATTTCTATGACACTGGACATGCAGATGACTGTGT
AGGTTTAGAACTTGTGGTTGAGCCGTGGATTGCTGGACTCTGGCCAGCCCTCAGAAAGCATTTTAGGTCAAGCAGAGGACAAGAGGAGAT
AAGTGGCGCACTCCCGGTGGCATCACCTGCATCCTCGAGGACAGACCTTGTGAAGTCAGAGCTGCTACACATTGAATCTCAAGTCGAGCT
TCTGAGATTCGATGATTCAGGAAGAAAGGATTCTGAGGTTTTGAAGCAAAATGCAGTGAACAGCAACCAATCCAATGTTGTAATTGAAGA
CTTTGAGTCCTCACTTACCCGTTCGGTACCCCCACTCTCACAAGCCTCTCTGAATATTCCTGGTTTACCCCCAGAATATTTACAGGTACA
TCTGCAGGAGTCTCTTGGCCAGGAGGAAAGCCAAGTATCTGTGACTTCAGCAGATCCAGTTTTTCAAGTGCCAATTTCAAAGGCAGTTCA
ACTTACTACGAATGATGCCATAAAAACCACTCTGCTGGTAGAATTGGACATTTCAAATACAGACTTTTCCTATCAGCCTGGAGATGCCTT
CAGCGTGATCTGCCCTAACAGTGATTCTGAGGTACAAAGCCTACTCCAAAGACTGCAGCTTGAAGATAAAAGAGAGCACTGCGTCCTTTT
GAAAATAAAGGCAGACACAAAGAAGAAAGGAGCTACCTTACCCCAGCATATACCTGCGGGATGTTCTCTCCAGTTCATTTTTACCTGGTG
TCTTGAAATCCGAGCAATTCCTAAAAAGGCATTTTTGCGAGCCCTTGTGGACTATACCAGTGACAGTGCTGAAAAGCGCAGGCTACAGGA
GCTGTGCAGTAAACAAGGGGCAGCCGATTATAGCCGCTTTGTACGAGATGCCTGTGCCTGCTTGTTGGATCTCCTCCTCGCTTTCCCTTC
TTGCCAGCCACCACTCAGTCTCCTGCTCGAACATCTTCCTAAACTTCAACCCAGACCATATTCGTGTGCAAGCTCAAGTTTATTTCACCC
AGGAAAGCTCCATTTTGTCTTCAACATTGTGGAATTTCTGTCTACTGCCACAACAGAGGTTCTGCGGAAGGGAGTATGTACAGGCTGGCT
GGCCTTGTTGGTTGCTTCAGTTCTTCAGCCAAACATACATGCATCCCATGAAGACAGCGGGAAAGCCCTGGCTCCTAAGATATCCATCTC
TCCTCGAACAACAAATTCTTTCCACTTACCAGATGACCCCTCAATCCCCATCATAATGGTGGGTCCAGGAACCGGCATAGCCCCGTTTAT
TGGGTTCCTACAACATAGAGAGAAACTCCAAGAACAACACCCAGATGGAAATTTTGGAGCAATGTGGTTGTTTTTTGGCTGCAGGCATAA
GGATAGGGATTATCTATTCAGAAAAGAGCTCAGACATTTCCTTAAGCATGGGATCTTAACTCATCTAAAGGTTTCCTTCTCAAGAGATGC
TCCTGTTGGGGAGGAGGAAGCCCCAGCAAAGTATGTGCAAGACAACATCCAGCTTCATGGCCAGCAGGTGGCGAGAATCCTCCTCCAGGA
GAACGGCCATATTTATGTGTGTGGGTTTGATTTGGCCAACTGTAACTTAAATGATGAGCATGTCAACAAAATGAACTCAGATAGAGTTCC
AGATGTGGTATTAATCAAGAAGAGCTATGACCGGACCAAACGTCAGCGTCGTAGAAACTGGAAATTGAAAGAGCTTGCAAGAGAGAGAGA
AAACATGGATACAGATGATGAAAGGCAATACCAAGATTTTCTTGAAGATCTTGAAGAAGATGAGGCAATTCGAAAAAATGTCAACATTTA
CAGAGATTCAGCCATCCCTGTGGAAAGTGACACCGATGATGAAGGAGCACCTCGAATTAGTCTGGCTGAGATGCTTGAAGACCTTCATAT
TTCCCAAGATGCCACTGGTGAAGAAGGTGCATCAATGCTGACATAATGAGATGTTGTAGACTGTTTCCATACATGGGCTTAAGAAGTTGG
ACAGAGTTACCTTAAGTGTCTCTACTATCTTTGCCTCCAGATTTCAAGAGGAGAAATTTAGTTTTAAACCTGAATAAACATGTTTGTTTT
CAGTGCTCACTCAAACCACTAAAACAGATGGATAGCTTTGAGGTTTTAGATAAGGAAAGATTATGGAGAATGTAGTTGTTATTGATTTTT
GGCAATTTTACATTTGGAATTTTATCACTGTGCTTTTTTATATGAGGCACTGTAGTATTTTCACATAGTATAGTACTCTGGATGTAAAAG
CTCAAAAATTGTGATTCCTTGAACGTTCACTAAATCTTCAAGCAAAAACACATTTTTACATTATTTTTACGTTGATTATTTTAGTGAAAG
ACCATATGAAGAAGCATTTTTAATATTAACTTGTTACATACTTTGATCCACTTTACATCATTTTTATGTTGTTGAGGTAGGGAAATTAGG
GTTCAGTTTATCACTGGACATTCAGGAGGCAAGTCAATCTTTTTTATTTCCTTATAAAATTAACTCTTCAAAAGCCGTTAAACAGAGAGT
TATCTTAATTTTTATTGCAGTAGGAGGAAATATATTTAAAATATTTGTAGATTTATAGCAAATAGAGACTCGTTATTTAAAGGTTAAATA
ACAATTTGTTCTTTTGTTGTTTTTGCCAGTTTAGGGCAGTAGCTGCTTTTGTCATAAATATCTTCCTACCACATCAAAAATGCTGCTTTT
AAAATTTTTGTTTATAAATTGAGAAGGAATTTTCTCTCTATAAGTTTCTGTCATTGAACAGATCACCATTAAAAAGAATATTAGAATCCA
GCATGAAGATAATGGCTAATAAAAATGAGGTACATACTTTATAAAACCATTAATCAGATTTGAATGAGGAATGCTTCCCACATCCTTGAA
AGAAAAACTGTGGCTTACGTTTTGAAGTATTCTGAGAATGAAGTATTAAGATCCAATTTCTATAAGCAAGATCAGACTTGTTAAGTATGC
CGCAAGTAAGAGCTAATTCATTCATTCCATGTGTGCCACTAAATAAAGAGATTGAGCAAGTGCCACTGTGTGGAACATTTTTCTTTTTTT
TAATATTGGACTTTCCAATTTTGAAATTATGGATAAAGTCCTAAATTTTCTATAGTGGCTTCTTTTCTGTCTGCATATTTTGTTAAAATT
GTGGATCTAAAAGCCATATCCTGTCTTTGGTGGTGGCCTGGTAGGAATGGCTTGTCCTAGTTCTTCAAAGGTAAGATTGACCAAAGCAAG
TTCTCATTGGTGGTCTGTGTTTACATCTTCCGTGTCAAGATATTTTAAAGCATGAAAATAAAGCCATTCTTGCCCTTTTTCGTGTGTTTG

>55903_55903_4_MTRR-NMD3_MTRR_chr5_7897360_ENST00000440940_NMD3_chr3_160965046_ENST00000351193_length(amino acids)=790AA_BP=664
MARRGFTVTCLEVMRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTGDPPDTARKFVKEIQ
NQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEISGAL
PVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQES
LGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKA
DTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPP
LSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKALAPKISISPRTT
NSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGE
EEAPAKYVQDNIQLHGQQVARILLQENGHIYVCGFDLANCNLNDEHVNKMNSDRVPDVVLIKKSYDRTKRQRRRNWKLKELARERENMDT

--------------------------------------------------------------
>55903_55903_5_MTRR-NMD3_MTRR_chr5_7897360_ENST00000440940_NMD3_chr3_160965046_ENST00000460469_length(transcript)=3480nt_BP=2004nt
GGTTCGTGCCCGGCTGGCGCGGCGTGGTTTCACTGTTACATGCCTTGAAGTGATGAGGAGGTTTCTGTTACTATATGCTACACAGCAGGG
ACAGGCAAAGGCCATCGCAGAAGAAATATGTGAGCAAGCTGTGGTACATGGATTTTCTGCAGATCTTCACTGTATTAGTGAATCCGATAA
GTATGACCTAAAAACCGAAACAGCTCCTCTTGTTGTTGTGGTTTCTACCACGGGCACCGGAGACCCACCCGACACAGCCCGCAAGTTTGT
TAAGGAAATACAGAACCAAACACTGCCGGTTGATTTCTTTGCTCACCTGCGGTATGGGTTACTGGGTCTCGGTGATTCAGAATACACCTA
CTTTTGCAATGGGGGGAAGATAATTGATAAACGACTTCAAGAGCTTGGAGCCCGGCATTTCTATGACACTGGACATGCAGATGACTGTGT
AGGTTTAGAACTTGTGGTTGAGCCGTGGATTGCTGGACTCTGGCCAGCCCTCAGAAAGCATTTTAGGTCAAGCAGAGGACAAGAGGAGAT
AAGTGGCGCACTCCCGGTGGCATCACCTGCATCCTCGAGGACAGACCTTGTGAAGTCAGAGCTGCTACACATTGAATCTCAAGTCGAGCT
TCTGAGATTCGATGATTCAGGAAGAAAGGATTCTGAGGTTTTGAAGCAAAATGCAGTGAACAGCAACCAATCCAATGTTGTAATTGAAGA
CTTTGAGTCCTCACTTACCCGTTCGGTACCCCCACTCTCACAAGCCTCTCTGAATATTCCTGGTTTACCCCCAGAATATTTACAGGTACA
TCTGCAGGAGTCTCTTGGCCAGGAGGAAAGCCAAGTATCTGTGACTTCAGCAGATCCAGTTTTTCAAGTGCCAATTTCAAAGGCAGTTCA
ACTTACTACGAATGATGCCATAAAAACCACTCTGCTGGTAGAATTGGACATTTCAAATACAGACTTTTCCTATCAGCCTGGAGATGCCTT
CAGCGTGATCTGCCCTAACAGTGATTCTGAGGTACAAAGCCTACTCCAAAGACTGCAGCTTGAAGATAAAAGAGAGCACTGCGTCCTTTT
GAAAATAAAGGCAGACACAAAGAAGAAAGGAGCTACCTTACCCCAGCATATACCTGCGGGATGTTCTCTCCAGTTCATTTTTACCTGGTG
TCTTGAAATCCGAGCAATTCCTAAAAAGGCATTTTTGCGAGCCCTTGTGGACTATACCAGTGACAGTGCTGAAAAGCGCAGGCTACAGGA
GCTGTGCAGTAAACAAGGGGCAGCCGATTATAGCCGCTTTGTACGAGATGCCTGTGCCTGCTTGTTGGATCTCCTCCTCGCTTTCCCTTC
TTGCCAGCCACCACTCAGTCTCCTGCTCGAACATCTTCCTAAACTTCAACCCAGACCATATTCGTGTGCAAGCTCAAGTTTATTTCACCC
AGGAAAGCTCCATTTTGTCTTCAACATTGTGGAATTTCTGTCTACTGCCACAACAGAGGTTCTGCGGAAGGGAGTATGTACAGGCTGGCT
GGCCTTGTTGGTTGCTTCAGTTCTTCAGCCAAACATACATGCATCCCATGAAGACAGCGGGAAAGCCCTGGCTCCTAAGATATCCATCTC
TCCTCGAACAACAAATTCTTTCCACTTACCAGATGACCCCTCAATCCCCATCATAATGGTGGGTCCAGGAACCGGCATAGCCCCGTTTAT
TGGGTTCCTACAACATAGAGAGAAACTCCAAGAACAACACCCAGATGGAAATTTTGGAGCAATGTGGTTGTTTTTTGGCTGCAGGCATAA
GGATAGGGATTATCTATTCAGAAAAGAGCTCAGACATTTCCTTAAGCATGGGATCTTAACTCATCTAAAGGTTTCCTTCTCAAGAGATGC
TCCTGTTGGGGAGGAGGAAGCCCCAGCAAAGTATGTGCAAGACAACATCCAGCTTCATGGCCAGCAGGTGGCGAGAATCCTCCTCCAGGA
GAACGGCCATATTTATGTGTGTGGGTTTGATTTGGCCAACTGTAACTTAAATGATGAGCATGTCAACAAAATGAACTCAGATAGAGTTCC
AGATGTGGTATTAATCAAGAAGAGCTATGACCGGACCAAACGTCAGCGTCGTAGAAACTGGAAATTGAAAGAGCTTGCAAGAGAGAGAGA
AAACATGGATACAGATGATGAAAGGCAATACCAAGATTTTCTTGAAGATCTTGAAGAAGATGAGGCAATTCGAAAAAATGTCAACATTTA
CAGAGATTCAGCCATCCCTGTGGAAAGTGACACCGATGATGAAGGAGCACCTCGAATTAGTCTGGCTGAGATGCTTGAAGACCTTCATAT
TTCCCAAGATGCCACTGGTGAAGAAGGTGCATCAATGCTGACATAATGAGATGTTGTAGACTGTTTCCATACATGGGCTTAAGAAGTTGG
ACAGAGTTACCTTAAGTGTCTCTACTATCTTTGCCTCCAGATTTCAAGAGGAGAAATTTAGTTTTAAACCTGAATAAACATGTTTGTTTT
CAGTGCTCACTCAAACCACTAAAACAGATGGATAGCTTTGAGGTTTTAGATAAGGAAAGATTATGGAGAATGTAGTTGTTATTGATTTTT
GGCAATTTTACATTTGGAATTTTATCACTGTGCTTTTTTATATGAGGCACTGTAGTATTTTCACATAGTATAGTACTCTGGATGTAAAAG
CTCAAAAATTGTGATTCCTTGAACGTTCACTAAATCTTCAAGCAAAAACACATTTTTACATTATTTTTACGTTGATTATTTTAGTGAAAG
ACCATATGAAGAAGCATTTTTAATATTAACTTGTTACATACTTTGATCCACTTTACATCATTTTTATGTTGTTGAGGTAGGGAAATTAGG
GTTCAGTTTATCACTGGACATTCAGGAGGCAAGTCAATCTTTTTTATTTCCTTATAAAATTAACTCTTCAAAAGCCGTTAAACAGAGAGT
TATCTTAATTTTTATTGCAGTAGGAGGAAATATATTTAAAATATTTGTAGATTTATAGCAAATAGAGACTCGTTATTTAAAGGTTAAATA
ACAATTTGTTCTTTTGTTGTTTTTGCCAGTTTAGGGCAGTAGCTGCTTTTGTCATAAATATCTTCCTACCACATCAAAAATGCTGCTTTT
AAAATTTTTGTTTATAAATTGAGAAGGAATTTTCTCTCTATAAGTTTCTGTCATTGAACAGATCACCATTAAAAAGAATATTAGAATCCA
GCATGAAGATAATGGCTAATAAAAATGAGGTACATACTTTATAAAACCATTAATCAGATTTGAATGAGGAATGCTTCCCACATCCTTGAA
AGAAAAACTGTGGCTTACGTTTTGAAGTATTCTGAGAATGAAGTATTAAGATCCAATTTCTATAAGCAAGATCAGACTTGTTAAGTATGC

>55903_55903_5_MTRR-NMD3_MTRR_chr5_7897360_ENST00000440940_NMD3_chr3_160965046_ENST00000460469_length(amino acids)=790AA_BP=664
MARRGFTVTCLEVMRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTGDPPDTARKFVKEIQ
NQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEISGAL
PVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQES
LGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKA
DTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPP
LSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKALAPKISISPRTT
NSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGE
EEAPAKYVQDNIQLHGQQVARILLQENGHIYVCGFDLANCNLNDEHVNKMNSDRVPDVVLIKKSYDRTKRQRRRNWKLKELARERENMDT

--------------------------------------------------------------
>55903_55903_6_MTRR-NMD3_MTRR_chr5_7897360_ENST00000440940_NMD3_chr3_160965046_ENST00000472947_length(transcript)=3130nt_BP=2004nt
GGTTCGTGCCCGGCTGGCGCGGCGTGGTTTCACTGTTACATGCCTTGAAGTGATGAGGAGGTTTCTGTTACTATATGCTACACAGCAGGG
ACAGGCAAAGGCCATCGCAGAAGAAATATGTGAGCAAGCTGTGGTACATGGATTTTCTGCAGATCTTCACTGTATTAGTGAATCCGATAA
GTATGACCTAAAAACCGAAACAGCTCCTCTTGTTGTTGTGGTTTCTACCACGGGCACCGGAGACCCACCCGACACAGCCCGCAAGTTTGT
TAAGGAAATACAGAACCAAACACTGCCGGTTGATTTCTTTGCTCACCTGCGGTATGGGTTACTGGGTCTCGGTGATTCAGAATACACCTA
CTTTTGCAATGGGGGGAAGATAATTGATAAACGACTTCAAGAGCTTGGAGCCCGGCATTTCTATGACACTGGACATGCAGATGACTGTGT
AGGTTTAGAACTTGTGGTTGAGCCGTGGATTGCTGGACTCTGGCCAGCCCTCAGAAAGCATTTTAGGTCAAGCAGAGGACAAGAGGAGAT
AAGTGGCGCACTCCCGGTGGCATCACCTGCATCCTCGAGGACAGACCTTGTGAAGTCAGAGCTGCTACACATTGAATCTCAAGTCGAGCT
TCTGAGATTCGATGATTCAGGAAGAAAGGATTCTGAGGTTTTGAAGCAAAATGCAGTGAACAGCAACCAATCCAATGTTGTAATTGAAGA
CTTTGAGTCCTCACTTACCCGTTCGGTACCCCCACTCTCACAAGCCTCTCTGAATATTCCTGGTTTACCCCCAGAATATTTACAGGTACA
TCTGCAGGAGTCTCTTGGCCAGGAGGAAAGCCAAGTATCTGTGACTTCAGCAGATCCAGTTTTTCAAGTGCCAATTTCAAAGGCAGTTCA
ACTTACTACGAATGATGCCATAAAAACCACTCTGCTGGTAGAATTGGACATTTCAAATACAGACTTTTCCTATCAGCCTGGAGATGCCTT
CAGCGTGATCTGCCCTAACAGTGATTCTGAGGTACAAAGCCTACTCCAAAGACTGCAGCTTGAAGATAAAAGAGAGCACTGCGTCCTTTT
GAAAATAAAGGCAGACACAAAGAAGAAAGGAGCTACCTTACCCCAGCATATACCTGCGGGATGTTCTCTCCAGTTCATTTTTACCTGGTG
TCTTGAAATCCGAGCAATTCCTAAAAAGGCATTTTTGCGAGCCCTTGTGGACTATACCAGTGACAGTGCTGAAAAGCGCAGGCTACAGGA
GCTGTGCAGTAAACAAGGGGCAGCCGATTATAGCCGCTTTGTACGAGATGCCTGTGCCTGCTTGTTGGATCTCCTCCTCGCTTTCCCTTC
TTGCCAGCCACCACTCAGTCTCCTGCTCGAACATCTTCCTAAACTTCAACCCAGACCATATTCGTGTGCAAGCTCAAGTTTATTTCACCC
AGGAAAGCTCCATTTTGTCTTCAACATTGTGGAATTTCTGTCTACTGCCACAACAGAGGTTCTGCGGAAGGGAGTATGTACAGGCTGGCT
GGCCTTGTTGGTTGCTTCAGTTCTTCAGCCAAACATACATGCATCCCATGAAGACAGCGGGAAAGCCCTGGCTCCTAAGATATCCATCTC
TCCTCGAACAACAAATTCTTTCCACTTACCAGATGACCCCTCAATCCCCATCATAATGGTGGGTCCAGGAACCGGCATAGCCCCGTTTAT
TGGGTTCCTACAACATAGAGAGAAACTCCAAGAACAACACCCAGATGGAAATTTTGGAGCAATGTGGTTGTTTTTTGGCTGCAGGCATAA
GGATAGGGATTATCTATTCAGAAAAGAGCTCAGACATTTCCTTAAGCATGGGATCTTAACTCATCTAAAGGTTTCCTTCTCAAGAGATGC
TCCTGTTGGGGAGGAGGAAGCCCCAGCAAAGTATGTGCAAGACAACATCCAGCTTCATGGCCAGCAGGTGGCGAGAATCCTCCTCCAGGA
GAACGGCCATATTTATGTGTGTGGGTTTGATTTGGCCAACTGTAACTTAAATGATGAGCATGTCAACAAAATGAACTCAGATAGAGTTCC
AGATGTGGTATTAATCAAGAAGAGCTATGACCGGACCAAACGTCAGCGTCGTAGAAACTGGAAATTGAAAGAGCTTGCAAGAGAGAGAGA
AAACATGGATACAGATGATGAAAGGCAATACCAAGATTTTCTTGAAGATCTTGAAGAAGATGAGGCAATTCGAAAAAATGTCAACATTTA
CAGAGATTCAGCCATCCCTGTGGAAAGTGACACCGATGATGAAGGAGCACCTCGAATTAGTCTGGCTGAGATGCTTGAAGACCTTCATAT
TTCCCAAGATGCCACTGGTGAAGAAGCCAAATCTGCACCTGAAGCTGCTGATTTAGAGTCAGAAGTCACTGAGGGGCCAAGTGTGGTGGT
TGACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGAGGGCAGATCACTTCAGGCCAGGAGTTCAAGACCAGCCTGGCCAACATAGTGAA
ACCCTGTCTCTACTAAAAATGCAAAAATTATCCGGGCGTGGTGGTGCACACATAGTCCCAGCTACTCGGGACGCTGAGGCAGGAGAATCA
CTTGAACCCAGGAGGCAGAGGTTGCAGTGAGTCGAGATCTGGCCACTGTACTCCAGCCTGGGCGACAGAGTGAGACTCTGTTCCCCCACT
CCCCCAATAAAAAAAGTCTGATGAGCAAGAAAAGTTCAGGGGTAGAGTTGCTTGTGTAATTGAGATGTTTAACAGCATCAGGCTAATTCC
TTGCCATAGTAGAACCCAGAAGCTCTGAGCTGTGTGCCAGGAGATACCTCCCTGGTCAGTACTTAGTACCAGAGTTTTCCCTAGATTCTT
TAATTTTAGTAAATGTGCTCACATTGAGTCAATCCTTACATAACTGGGTATGTTATTTCCAGCCCAAGGAATGTTTATTTTTAAAAATAT
TTTTAATTATCCATAATTTCAGACTTACAAAATGTCGCAAGTATTCCCGGATACCATTTACCTAGATTTGCCAAATGTAAACAATTTGCC

>55903_55903_6_MTRR-NMD3_MTRR_chr5_7897360_ENST00000440940_NMD3_chr3_160965046_ENST00000472947_length(amino acids)=816AA_BP=664
MARRGFTVTCLEVMRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTGDPPDTARKFVKEIQ
NQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEISGAL
PVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQES
LGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKA
DTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPP
LSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKALAPKISISPRTT
NSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGE
EEAPAKYVQDNIQLHGQQVARILLQENGHIYVCGFDLANCNLNDEHVNKMNSDRVPDVVLIKKSYDRTKRQRRRNWKLKELARERENMDT
DDERQYQDFLEDLEEDEAIRKNVNIYRDSAIPVESDTDDEGAPRISLAEMLEDLHISQDATGEEAKSAPEAADLESEVTEGPSVVVDACN

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Fusion Gene PPI Analysis for MTRR-NMD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MTRR-NMD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MTRR-NMD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource