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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MTRR-SLC30A5 (FusionGDB2 ID:55904)

Fusion Gene Summary for MTRR-SLC30A5

check button Fusion gene summary
Fusion gene informationFusion gene name: MTRR-SLC30A5
Fusion gene ID: 55904
HgeneTgene
Gene symbol

MTRR

SLC30A5

Gene ID

4552

64924

Gene name5-methyltetrahydrofolate-homocysteine methyltransferase reductasesolute carrier family 30 member 5
SynonymsMSR|cblEZNT5|ZNTL1|ZTL1|ZnT-5
Cytomap

5p15.31

5q13.1-q13.2

Type of geneprotein-codingprotein-coding
Descriptionmethionine synthase reductase[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing)methionine synthase reductase, mitochondrialzinc transporter 5solute carrier family 30 (zinc transporter), member 5zinc transporter ZTL1znT-like transporter 1
Modification date2020031520200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000341013, ENST00000264668, 
ENST00000440940, ENST00000502509, 
ENST00000396591, ENST00000380860, 
ENST00000502979, 
Fusion gene scores* DoF score3 X 2 X 3=182 X 2 X 2=8
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context

PubMed: MTRR [Title/Abstract] AND SLC30A5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMTRR(7878435)-SLC30A5(68413066), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMTRR

GO:0009086

methionine biosynthetic process

11466310

HgeneMTRR

GO:0043418

homocysteine catabolic process

11466310

HgeneMTRR

GO:0046655

folic acid metabolic process

11466310

HgeneMTRR

GO:1904042

negative regulation of cystathionine beta-synthase activity

24416422

TgeneSLC30A5

GO:0006824

cobalt ion transport

10330022|11937503

TgeneSLC30A5

GO:0006829

zinc ion transport

10330022|11937503

TgeneSLC30A5

GO:0006882

cellular zinc ion homeostasis

11937503

TgeneSLC30A5

GO:0010043

response to zinc ion

11937503


check buttonFusion gene breakpoints across MTRR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC30A5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HC-8260-01AMTRRchr5

7878435

-SLC30A5chr5

68413066

+
ChimerDB4PRADTCGA-HC-8260-01AMTRRchr5

7878435

+SLC30A5chr5

68413066

+


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Fusion Gene ORF analysis for MTRR-SLC30A5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000341013ENST00000396591MTRRchr5

7878435

+SLC30A5chr5

68413066

+
3UTR-intronENST00000341013ENST00000380860MTRRchr5

7878435

+SLC30A5chr5

68413066

+
3UTR-intronENST00000341013ENST00000502979MTRRchr5

7878435

+SLC30A5chr5

68413066

+
5CDS-intronENST00000264668ENST00000380860MTRRchr5

7878435

+SLC30A5chr5

68413066

+
5CDS-intronENST00000264668ENST00000502979MTRRchr5

7878435

+SLC30A5chr5

68413066

+
5CDS-intronENST00000440940ENST00000380860MTRRchr5

7878435

+SLC30A5chr5

68413066

+
5CDS-intronENST00000440940ENST00000502979MTRRchr5

7878435

+SLC30A5chr5

68413066

+
In-frameENST00000264668ENST00000396591MTRRchr5

7878435

+SLC30A5chr5

68413066

+
In-frameENST00000440940ENST00000396591MTRRchr5

7878435

+SLC30A5chr5

68413066

+
intron-3CDSENST00000502509ENST00000396591MTRRchr5

7878435

+SLC30A5chr5

68413066

+
intron-intronENST00000502509ENST00000380860MTRRchr5

7878435

+SLC30A5chr5

68413066

+
intron-intronENST00000502509ENST00000502979MTRRchr5

7878435

+SLC30A5chr5

68413066

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264668MTRRchr57878435+ENST00000396591SLC30A5chr568413066+3360891301907625
ENST00000440940MTRRchr57878435+ENST00000396591SLC30A5chr568413066+3301832131848611

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264668ENST00000396591MTRRchr57878435+SLC30A5chr568413066+5.44E-050.99994564
ENST00000440940ENST00000396591MTRRchr57878435+SLC30A5chr568413066+7.31E-050.9999269

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Fusion Genomic Features for MTRR-SLC30A5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MTRR-SLC30A5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:7878435/chr5:68413066)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTRRchr5:7878435chr5:68413066ENST00000264668+5155_147287726.0DomainFlavodoxin-like
HgeneMTRRchr5:7878435chr5:68413066ENST00000341013+48271_53320858.333333333333336DomainFAD-binding FR-type
HgeneMTRRchr5:7878435chr5:68413066ENST00000341013+485_14720858.333333333333336DomainFlavodoxin-like
HgeneMTRRchr5:7878435chr5:68413066ENST00000440940+5155_147260699.0DomainFlavodoxin-like
HgeneMTRRchr5:7878435chr5:68413066ENST00000264668+51593_124287726.0Nucleotide bindingFMN
HgeneMTRRchr5:7878435chr5:68413066ENST00000341013+48487_49020858.333333333333336Nucleotide bindingFAD
HgeneMTRRchr5:7878435chr5:68413066ENST00000341013+48610_61120858.333333333333336Nucleotide bindingNADP
HgeneMTRRchr5:7878435chr5:68413066ENST00000341013+48624_62620858.333333333333336Nucleotide bindingNADP
HgeneMTRRchr5:7878435chr5:68413066ENST00000341013+4893_12420858.333333333333336Nucleotide bindingFMN
HgeneMTRRchr5:7878435chr5:68413066ENST00000440940+51593_124260699.0Nucleotide bindingFMN
HgeneMTRRchr5:7878435chr5:68413066ENST00000264668+515166_247287726.0RegionNote=Hinge
HgeneMTRRchr5:7878435chr5:68413066ENST00000341013+48166_24720858.333333333333336RegionNote=Hinge
HgeneMTRRchr5:7878435chr5:68413066ENST00000440940+515166_247260699.0RegionNote=Hinge
TgeneSLC30A5chr5:7878435chr5:68413066ENST000003808600412_200119.0Compositional biasNote=Poly-Gly
TgeneSLC30A5chr5:7878435chr5:68413066ENST000005029790312_20078.0Compositional biasNote=Poly-Gly
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004542_5780119.0RegionNote=His-rich loop
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916542_578427766.0RegionNote=His-rich loop
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903542_578078.0RegionNote=His-rich loop
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004120_1200119.0Topological domainExtracellular
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004142_1520119.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004174_1930119.0Topological domainExtracellular
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000380860041_320119.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004215_2380119.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004260_2670119.0Topological domainExtracellular
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004289_3030119.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004325_3420119.0Topological domainExtracellular
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004364_4180119.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004440_4480119.0Topological domainExtracellular
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004470_4830119.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004505_5200119.0Topological domainExtracellular
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004542_5920119.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST000003808600454_560119.0Topological domainExtracellular
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004614_6170119.0Topological domainExtracellular
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004639_7650119.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST000003808600478_980119.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916440_448427766.0Topological domainExtracellular
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916470_483427766.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916505_520427766.0Topological domainExtracellular
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916542_592427766.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916614_617427766.0Topological domainExtracellular
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916639_765427766.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903120_120078.0Topological domainExtracellular
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903142_152078.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903174_193078.0Topological domainExtracellular
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000502979031_32078.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903215_238078.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903260_267078.0Topological domainExtracellular
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903289_303078.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903325_342078.0Topological domainExtracellular
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903364_418078.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903440_448078.0Topological domainExtracellular
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903470_483078.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903505_520078.0Topological domainExtracellular
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903542_592078.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST000005029790354_56078.0Topological domainExtracellular
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903614_617078.0Topological domainExtracellular
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903639_765078.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST000005029790378_98078.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004121_1410119.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004153_1730119.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004194_2140119.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004239_2590119.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004268_2880119.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004304_3240119.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST000003808600433_530119.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004343_3630119.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004419_4390119.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004449_4690119.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004484_5040119.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004521_5410119.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST000003808600457_770119.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004593_6130119.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000038086004618_6380119.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST000003808600499_1190119.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916449_469427766.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916484_504427766.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916521_541427766.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916593_613427766.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916618_638427766.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903121_141078.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903153_173078.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903194_214078.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903239_259078.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903268_288078.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903304_324078.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST000005029790333_53078.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903343_363078.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903419_439078.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903449_469078.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903484_504078.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903521_541078.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST000005029790357_77078.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903593_613078.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000050297903618_638078.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST000005029790399_119078.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTRRchr5:7878435chr5:68413066ENST00000264668+515271_533287726.0DomainFAD-binding FR-type
HgeneMTRRchr5:7878435chr5:68413066ENST00000440940+515271_533260699.0DomainFAD-binding FR-type
HgeneMTRRchr5:7878435chr5:68413066ENST00000264668+515487_490287726.0Nucleotide bindingFAD
HgeneMTRRchr5:7878435chr5:68413066ENST00000264668+515610_611287726.0Nucleotide bindingNADP
HgeneMTRRchr5:7878435chr5:68413066ENST00000264668+515624_626287726.0Nucleotide bindingNADP
HgeneMTRRchr5:7878435chr5:68413066ENST00000440940+515487_490260699.0Nucleotide bindingFAD
HgeneMTRRchr5:7878435chr5:68413066ENST00000440940+515610_611260699.0Nucleotide bindingNADP
HgeneMTRRchr5:7878435chr5:68413066ENST00000440940+515624_626260699.0Nucleotide bindingNADP
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000039659191612_20427766.0Compositional biasNote=Poly-Gly
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916120_120427766.0Topological domainExtracellular
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916142_152427766.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916174_193427766.0Topological domainExtracellular
TgeneSLC30A5chr5:7878435chr5:68413066ENST000003965919161_32427766.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916215_238427766.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916260_267427766.0Topological domainExtracellular
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916289_303427766.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916325_342427766.0Topological domainExtracellular
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916364_418427766.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000039659191654_56427766.0Topological domainExtracellular
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000039659191678_98427766.0Topological domainCytoplasmic
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916121_141427766.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916153_173427766.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916194_214427766.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916239_259427766.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916268_288427766.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916304_324427766.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000039659191633_53427766.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916343_363427766.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST00000396591916419_439427766.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000039659191657_77427766.0TransmembraneHelical
TgeneSLC30A5chr5:7878435chr5:68413066ENST0000039659191699_119427766.0TransmembraneHelical


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Fusion Gene Sequence for MTRR-SLC30A5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>55904_55904_1_MTRR-SLC30A5_MTRR_chr5_7878435_ENST00000264668_SLC30A5_chr5_68413066_ENST00000396591_length(transcript)=3360nt_BP=891nt
GGAGCTTTCTATTGGTCCTGGGTACCGAGCATGGGCGCTGCGTCAGTGCGCGCTGGCGCAAGGTTGGTGGAAGTCGCGTTGTGCAGTTTC
ACTGTTACATGCCTTGAAGTGATGAGGAGGTTTCTGTTACTATATGCTACACAGCAGGGACAGGCAAAGGCCATCGCAGAAGAAATATGT
GAGCAAGCTGTGGTACATGGATTTTCTGCAGATCTTCACTGTATTAGTGAATCCGATAAGTATGACCTAAAAACCGAAACAGCTCCTCTT
GTTGTTGTGGTTTCTACCACGGGCACCGGAGACCCACCCGACACAGCCCGCAAGTTTGTTAAGGAAATACAGAACCAAACACTGCCGGTT
GATTTCTTTGCTCACCTGCGGTATGGGTTACTGGGTCTCGGTGATTCAGAATACACCTACTTTTGCAATGGGGGGAAGATAATTGATAAA
CGACTTCAAGAGCTTGGAGCCCGGCATTTCTATGACACTGGACATGCAGATGACTGTGTAGGTTTAGAACTTGTGGTTGAGCCGTGGATT
GCTGGACTCTGGCCAGCCCTCAGAAAGCATTTTAGGTCAAGCAGAGGACAAGAGGAGATAAGTGGCGCACTCCCGGTGGCATCACCTGCA
TCCTCGAGGACAGACCTTGTGAAGTCAGAGCTGCTACACATTGAATCTCAAGTCGAGCTTCTGAGATTCGATGATTCAGGAAGAAAGGAT
TCTGAGGTTTTGAAGCAAAATGCAGTGAACAGCAACCAATCCAATGTTGTAATTGAAGACTTTGAGTCCTCACTTACCCGTTCGGTACCC
CCACTCTCACAAGCCTCTCTGAATATTCCTGGTTTACCCCCAGAATATTTACAGGTACATCTGCAGGAGTCTCTTGGCCAGCTTTTTACC
TTTGTGGAATTATTCTATGGCGTGCTGACCAATAGTCTGGGCCTGATCTCGGATGGATTCCACATGCTTTTTGACTGCTCTGCTTTAGTC
ATGGGACTTTTTGCTGCCCTGATGAGTAGGTGGAAAGCCACTCGGATTTTCTCCTATGGGTACGGCCGAATAGAAATTCTGTCTGGATTT
ATTAATGGACTTTTTCTAATAGTAATAGCGTTTTTTGTGTTTATGGAGTCAGTGGCTAGATTGATTGATCCTCCAGAATTAGACACTCAC
ATGTTAACACCAGTCTCAGTTGGAGGGCTGATAGTAAACCTTATTGGTATCTGTGCCTTTAGCCATGCCCATAGCCATGCCCATGGAGCT
TCTCAAGGAAGCTGTCACTCATCTGATCACAGCCATTCACACCATATGCATGGACACAGTGACCATGGGCATGGTCACAGCCACGGATCT
GCGGGTGGAGGCATGAATGCTAACATGAGGGGTGTATTTCTACATGTTTTGGCAGATACACTTGGCAGCATTGGTGTGATCGTATCCACA
GTTCTTATAGAGCAGTTTGGATGGTTCATCGCTGACCCACTCTGTTCTCTTTTTATTGCTATATTAATATTTCTCAGTGTTGTTCCACTG
ATTAAAGATGCCTGCCAGGTTCTACTCCTGAGATTGCCACCAGAATATGAAAAAGAACTACATATTGCTTTAGAAAAGATACAGAAAATT
GAAGGATTAATATCATACCGAGACCCTCATTTTTGGCGTCATTCTGCTAGTATTGTGGCAGGAACAATTCATATACAGGTGACATCTGAT
GTGCTAGAACAAAGAATAGTACAGCAGGTTACAGGAATACTTAAAGATGCTGGAGTAAACAATTTAACAATTCAAGTGGAAAAGGAGGCA
TACTTTCAACATATGTCTGGCCTAAGTACTGGATTTCATGATGTTCTGGCTATGACAAAACAAATGGAATCCATGAAATACTGCAAAGAT
GGTACTTACATCATGTGAGATAACTCAAGAATTACCCCTGGAGAATAAACAATGAAGATTAAATGACTCAGTATTTGTAATATTGCCAGA
AGGATAAAAATTACACATTAACTGTACAGAAACAGAGTTCCCTACTACTGGATCAAGGAATCTTTCTTGAAGGAAATTTAAATACAGAAT
GAAACATTAATGGTAAAAGTGGAGTAATTATTTAAATTATGTGTATAAAAGGAATCAAATTTTGAGTAAACATGATGTATTACATCATCT
TCAAAAATAGATATGATGGATTCTAGTGAAGACCAAAATTACTTCTGTTTACTTTCTATCAGGAAGCATCTCCATTGTAAATATGTATTT
ACATGTTTATTACAAAGACCCAAATGAAAAATTTTTAGTCCATTTTTTGCATAGCCTAAAGATAAAATAGGAATAAAAGTTCTATATTTA
TGGATTTTCTGTATATAAAACTGGTTTCTAATTATAACTTAAGTCCATTAAGTAAAATCTGTATTGCCACTTTAAATGTAAACTAAATTA
TTTGGGAGAAACTTCAACCACTGATATGAGATAAGCAATGAGAATAGGGAAGTGTATAACATCACAGTTTTTGATGTATTACAAAAATCA
ACCACTCTATAAAATAAATTTTTTTTACTTTTGGTAATATTTGCAAATGAATAATTAATTTATTAGGGTAAAGAACTTATACTAAGTTGT
GTCCATGTTATTCATTTACTTACCATGTTCCTTTAAAGTAGAATATTTCCTTTCTTGTTATATATTTGACATTCCAAGCTGCTTATCAAG
CTGGTATCCAAGCAGTGGTAAGCTTTCATCCTTTCTTAGCTCCATAACGTTGTGAAACAGCCAGTTAAGAGAATCGTAAATAATTGTCAA
CTCACAGTTGAATTCTCTGCCTATGTAGGTAACTTTTTTCTAATTTCTGGAACATATAGATATATAAGAAATATCAAAGAATAGGTAGTT
ATTTCAAAGTTTAATAAGTAAAACTTGTTCATAAACATTTGAGCACCATGAAATCAAAATACCCTATAACTACTTTCTATAGTCATATCT
AATTTATATTTTTTTCATTTCCAGTTGTAACTAGATATGTAGTAAAGTCTGAAAAGACTTTACCATAGACAATAACATGCAGTTTTATCA
GCACCAAAGAATGTTGTCCAAAAGAAACTTTTTAATACCTGTCTTTCTATTTATAACATCTGAATATTTTCATTCTTATATTAAGAATTT
TGATAAGTAGATTGAATTTAGTATGAGTACTATTTTCTTATATATACCACAATGGCAAACATGTATTATAAATCATATTTTTGTCTTACC
AATTTTAATATATGAGGGGTTTTAGAAATTTGTTGTAAGTTATTTTTATATTCCTTGTCTTTTGCATATTTTTTGGCCAAAATCTTCAAT

>55904_55904_1_MTRR-SLC30A5_MTRR_chr5_7878435_ENST00000264668_SLC30A5_chr5_68413066_ENST00000396591_length(amino acids)=625AA_BP=287
MGAASVRAGARLVEVALCSFTVTCLEVMRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTG
DPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKH
FRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIP
GLPPEYLQVHLQESLGQLFTFVELFYGVLTNSLGLISDGFHMLFDCSALVMGLFAALMSRWKATRIFSYGYGRIEILSGFINGLFLIVIA
FFVFMESVARLIDPPELDTHMLTPVSVGGLIVNLIGICAFSHAHSHAHGASQGSCHSSDHSHSHHMHGHSDHGHGHSHGSAGGGMNANMR
GVFLHVLADTLGSIGVIVSTVLIEQFGWFIADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKELHIALEKIQKIEGLISYRDPH

--------------------------------------------------------------
>55904_55904_2_MTRR-SLC30A5_MTRR_chr5_7878435_ENST00000440940_SLC30A5_chr5_68413066_ENST00000396591_length(transcript)=3301nt_BP=832nt
GGTTCGTGCCCGGCTGGCGCGGCGTGGTTTCACTGTTACATGCCTTGAAGTGATGAGGAGGTTTCTGTTACTATATGCTACACAGCAGGG
ACAGGCAAAGGCCATCGCAGAAGAAATATGTGAGCAAGCTGTGGTACATGGATTTTCTGCAGATCTTCACTGTATTAGTGAATCCGATAA
GTATGACCTAAAAACCGAAACAGCTCCTCTTGTTGTTGTGGTTTCTACCACGGGCACCGGAGACCCACCCGACACAGCCCGCAAGTTTGT
TAAGGAAATACAGAACCAAACACTGCCGGTTGATTTCTTTGCTCACCTGCGGTATGGGTTACTGGGTCTCGGTGATTCAGAATACACCTA
CTTTTGCAATGGGGGGAAGATAATTGATAAACGACTTCAAGAGCTTGGAGCCCGGCATTTCTATGACACTGGACATGCAGATGACTGTGT
AGGTTTAGAACTTGTGGTTGAGCCGTGGATTGCTGGACTCTGGCCAGCCCTCAGAAAGCATTTTAGGTCAAGCAGAGGACAAGAGGAGAT
AAGTGGCGCACTCCCGGTGGCATCACCTGCATCCTCGAGGACAGACCTTGTGAAGTCAGAGCTGCTACACATTGAATCTCAAGTCGAGCT
TCTGAGATTCGATGATTCAGGAAGAAAGGATTCTGAGGTTTTGAAGCAAAATGCAGTGAACAGCAACCAATCCAATGTTGTAATTGAAGA
CTTTGAGTCCTCACTTACCCGTTCGGTACCCCCACTCTCACAAGCCTCTCTGAATATTCCTGGTTTACCCCCAGAATATTTACAGGTACA
TCTGCAGGAGTCTCTTGGCCAGCTTTTTACCTTTGTGGAATTATTCTATGGCGTGCTGACCAATAGTCTGGGCCTGATCTCGGATGGATT
CCACATGCTTTTTGACTGCTCTGCTTTAGTCATGGGACTTTTTGCTGCCCTGATGAGTAGGTGGAAAGCCACTCGGATTTTCTCCTATGG
GTACGGCCGAATAGAAATTCTGTCTGGATTTATTAATGGACTTTTTCTAATAGTAATAGCGTTTTTTGTGTTTATGGAGTCAGTGGCTAG
ATTGATTGATCCTCCAGAATTAGACACTCACATGTTAACACCAGTCTCAGTTGGAGGGCTGATAGTAAACCTTATTGGTATCTGTGCCTT
TAGCCATGCCCATAGCCATGCCCATGGAGCTTCTCAAGGAAGCTGTCACTCATCTGATCACAGCCATTCACACCATATGCATGGACACAG
TGACCATGGGCATGGTCACAGCCACGGATCTGCGGGTGGAGGCATGAATGCTAACATGAGGGGTGTATTTCTACATGTTTTGGCAGATAC
ACTTGGCAGCATTGGTGTGATCGTATCCACAGTTCTTATAGAGCAGTTTGGATGGTTCATCGCTGACCCACTCTGTTCTCTTTTTATTGC
TATATTAATATTTCTCAGTGTTGTTCCACTGATTAAAGATGCCTGCCAGGTTCTACTCCTGAGATTGCCACCAGAATATGAAAAAGAACT
ACATATTGCTTTAGAAAAGATACAGAAAATTGAAGGATTAATATCATACCGAGACCCTCATTTTTGGCGTCATTCTGCTAGTATTGTGGC
AGGAACAATTCATATACAGGTGACATCTGATGTGCTAGAACAAAGAATAGTACAGCAGGTTACAGGAATACTTAAAGATGCTGGAGTAAA
CAATTTAACAATTCAAGTGGAAAAGGAGGCATACTTTCAACATATGTCTGGCCTAAGTACTGGATTTCATGATGTTCTGGCTATGACAAA
ACAAATGGAATCCATGAAATACTGCAAAGATGGTACTTACATCATGTGAGATAACTCAAGAATTACCCCTGGAGAATAAACAATGAAGAT
TAAATGACTCAGTATTTGTAATATTGCCAGAAGGATAAAAATTACACATTAACTGTACAGAAACAGAGTTCCCTACTACTGGATCAAGGA
ATCTTTCTTGAAGGAAATTTAAATACAGAATGAAACATTAATGGTAAAAGTGGAGTAATTATTTAAATTATGTGTATAAAAGGAATCAAA
TTTTGAGTAAACATGATGTATTACATCATCTTCAAAAATAGATATGATGGATTCTAGTGAAGACCAAAATTACTTCTGTTTACTTTCTAT
CAGGAAGCATCTCCATTGTAAATATGTATTTACATGTTTATTACAAAGACCCAAATGAAAAATTTTTAGTCCATTTTTTGCATAGCCTAA
AGATAAAATAGGAATAAAAGTTCTATATTTATGGATTTTCTGTATATAAAACTGGTTTCTAATTATAACTTAAGTCCATTAAGTAAAATC
TGTATTGCCACTTTAAATGTAAACTAAATTATTTGGGAGAAACTTCAACCACTGATATGAGATAAGCAATGAGAATAGGGAAGTGTATAA
CATCACAGTTTTTGATGTATTACAAAAATCAACCACTCTATAAAATAAATTTTTTTTACTTTTGGTAATATTTGCAAATGAATAATTAAT
TTATTAGGGTAAAGAACTTATACTAAGTTGTGTCCATGTTATTCATTTACTTACCATGTTCCTTTAAAGTAGAATATTTCCTTTCTTGTT
ATATATTTGACATTCCAAGCTGCTTATCAAGCTGGTATCCAAGCAGTGGTAAGCTTTCATCCTTTCTTAGCTCCATAACGTTGTGAAACA
GCCAGTTAAGAGAATCGTAAATAATTGTCAACTCACAGTTGAATTCTCTGCCTATGTAGGTAACTTTTTTCTAATTTCTGGAACATATAG
ATATATAAGAAATATCAAAGAATAGGTAGTTATTTCAAAGTTTAATAAGTAAAACTTGTTCATAAACATTTGAGCACCATGAAATCAAAA
TACCCTATAACTACTTTCTATAGTCATATCTAATTTATATTTTTTTCATTTCCAGTTGTAACTAGATATGTAGTAAAGTCTGAAAAGACT
TTACCATAGACAATAACATGCAGTTTTATCAGCACCAAAGAATGTTGTCCAAAAGAAACTTTTTAATACCTGTCTTTCTATTTATAACAT
CTGAATATTTTCATTCTTATATTAAGAATTTTGATAAGTAGATTGAATTTAGTATGAGTACTATTTTCTTATATATACCACAATGGCAAA
CATGTATTATAAATCATATTTTTGTCTTACCAATTTTAATATATGAGGGGTTTTAGAAATTTGTTGTAAGTTATTTTTATATTCCTTGTC

>55904_55904_2_MTRR-SLC30A5_MTRR_chr5_7878435_ENST00000440940_SLC30A5_chr5_68413066_ENST00000396591_length(amino acids)=611AA_BP=273
MARRGFTVTCLEVMRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTGDPPDTARKFVKEIQ
NQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEISGAL
PVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQES
LGQLFTFVELFYGVLTNSLGLISDGFHMLFDCSALVMGLFAALMSRWKATRIFSYGYGRIEILSGFINGLFLIVIAFFVFMESVARLIDP
PELDTHMLTPVSVGGLIVNLIGICAFSHAHSHAHGASQGSCHSSDHSHSHHMHGHSDHGHGHSHGSAGGGMNANMRGVFLHVLADTLGSI
GVIVSTVLIEQFGWFIADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKELHIALEKIQKIEGLISYRDPHFWRHSASIVAGTIH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MTRR-SLC30A5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MTRR-SLC30A5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MTRR-SLC30A5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource