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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MTSS1L-DGCR8 (FusionGDB2 ID:55914)

Fusion Gene Summary for MTSS1L-DGCR8

Fusion gene summary

Fusion gene information	Fusion gene name: MTSS1L-DGCR8
	Fusion gene ID: 55914
		Hgene	Tgene
	Gene symbol	MTSS1L	DGCR8
	Gene ID	92154	54487
	Gene name	MTSS I-BAR domain containing 2	DGCR8 microprocessor complex subunit
	Synonyms	ABBA\|ABBA-1\|ABBA1\|MTSS1L	C22orf12\|DGCRK6\|Gy1\|pasha
	Cytomap	16q22.1	22q11.21
	Type of gene	protein-coding	protein-coding
	Description	protein MTSS 2MTSS1-like proteinMTSS1L, I-BAR domain containingactin-bundling with BAIAP2 homology protein 1metastasis suppressor 1-like	microprocessor complex subunit DGCR8DiGeorge syndrome critical region 8DiGeorge syndrome critical region gene 8
	Modification date	20200313	20200320
	UniProtAcc	.	Q8WYQ5
	Ensembl transtripts involved in fusion gene	ENST00000338779,	ENST00000351989, ENST00000383024, ENST00000407755,
Fusion gene scores	* DoF score	6 X 7 X 6=252	9 X 8 X 6=432
	# samples	7	9
	** MAII score	log2(7/252*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/432*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MTSS1L [Title/Abstract] AND DGCR8 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MTSS1L(70719625)-DGCR8(20077498), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MTSS1L	GO:0036120	cellular response to platelet-derived growth factor stimulus	20875796
Hgene	MTSS1L	GO:0090630	activation of GTPase activity	20875796
Tgene	DGCR8	GO:0031053	primary miRNA processing	15531877\|15574589\|24449907\|24910438

Fusion gene breakpoints across MTSS1L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DGCR8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-13-1497	MTSS1L	chr16	70719625	-	DGCR8	chr22	20077498	+

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Fusion Gene ORF analysis for MTSS1L-DGCR8

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000338779	ENST00000351989	MTSS1L	chr16	70719625	-	DGCR8	chr22	20077498	+
In-frame	ENST00000338779	ENST00000383024	MTSS1L	chr16	70719625	-	DGCR8	chr22	20077498	+
In-frame	ENST00000338779	ENST00000407755	MTSS1L	chr16	70719625	-	DGCR8	chr22	20077498	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000338779	MTSS1L	chr16	70719625	-	ENST00000351989	DGCR8	chr22	20077498	+	3406	344	29	1642	537
ENST00000338779	MTSS1L	chr16	70719625	-	ENST00000383024	DGCR8	chr22	20077498	+	3311	344	29	1543	504
ENST00000338779	MTSS1L	chr16	70719625	-	ENST00000407755	DGCR8	chr22	20077498	+	3308	344	29	1543	504

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000338779	ENST00000351989	MTSS1L	chr16	70719625	-	DGCR8	chr22	20077498	+	0.002371355	0.9976286
ENST00000338779	ENST00000383024	MTSS1L	chr16	70719625	-	DGCR8	chr22	20077498	+	0.001743241	0.99825674
ENST00000338779	ENST00000407755	MTSS1L	chr16	70719625	-	DGCR8	chr22	20077498	+	0.001766464	0.99823356

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Fusion Genomic Features for MTSS1L-DGCR8

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MTSS1L-DGCR8

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:70719625/chr22:20077498)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	DGCR8 Q8WYQ5
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity). {ECO:0000250\|UniProtKB:Q9EQM6, ECO:0000269\|PubMed:15531877, ECO:0000269\|PubMed:15574589, ECO:0000269\|PubMed:15589161, ECO:0000269\|PubMed:16751099, ECO:0000269\|PubMed:16906129, ECO:0000269\|PubMed:16963499, ECO:0000269\|PubMed:17159994, ECO:0000269\|PubMed:25799998, ECO:0000269\|PubMed:26027739, ECO:0000269\|PubMed:26748718}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DGCR8

chr16:70719625

chr22:20077498

ENST00000351989

511_578

341

774.0

Domain

DRBM 1

Tgene

DGCR8

chr16:70719625

chr22:20077498

ENST00000351989

620_685

341

774.0

Domain

DRBM 2

Tgene

DGCR8

chr16:70719625

chr22:20077498

ENST00000383024

511_578

341

741.0

Domain

DRBM 1

Tgene

DGCR8

chr16:70719625

chr22:20077498

ENST00000383024

620_685

341

741.0

Domain

DRBM 2

Tgene

DGCR8

chr16:70719625

chr22:20077498

ENST00000407755

511_578

341

741.0

Domain

DRBM 1

Tgene

DGCR8

chr16:70719625

chr22:20077498

ENST00000407755

620_685

341

741.0

Domain

DRBM 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MTSS1L

chr16:70719625

chr22:20077498

ENST00000338779

135_159

748.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

MTSS1L

chr16:70719625

chr22:20077498

ENST00000338779

252_383

748.0

Compositional bias

Note=Ser-rich

Hgene

MTSS1L

chr16:70719625

chr22:20077498

ENST00000338779

1_252

748.0

Domain

IMD

Hgene

MTSS1L

chr16:70719625

chr22:20077498

ENST00000338779

719_736

748.0

Domain

Note=WH2

Tgene

DGCR8

chr16:70719625

chr22:20077498

ENST00000351989

301_334

341

774.0

Domain

Tgene

DGCR8

chr16:70719625

chr22:20077498

ENST00000383024

301_334

341

741.0

Domain

Tgene

DGCR8

chr16:70719625

chr22:20077498

ENST00000407755

301_334

341

741.0

Domain

Tgene

DGCR8

chr16:70719625

chr22:20077498

ENST00000351989

1_275

341

774.0

Region

Note=Necessary for nuclear localization and retention

Tgene

DGCR8

chr16:70719625

chr22:20077498

ENST00000351989

276_751

341

774.0

Region

Note=Necessary for heme-binding and pri-miRNA processing

Tgene

DGCR8

chr16:70719625

chr22:20077498

ENST00000383024

1_275

341

741.0

Region

Note=Necessary for nuclear localization and retention

Tgene

DGCR8

chr16:70719625

chr22:20077498

ENST00000383024

276_751

341

741.0

Region

Note=Necessary for heme-binding and pri-miRNA processing

Tgene

DGCR8

chr16:70719625

chr22:20077498

ENST00000407755

1_275

341

741.0

Region

Note=Necessary for nuclear localization and retention

Tgene

DGCR8

chr16:70719625

chr22:20077498

ENST00000407755

276_751

341

741.0

Region

Note=Necessary for heme-binding and pri-miRNA processing

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Fusion Gene Sequence for MTSS1L-DGCR8

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>55914_55914_1_MTSS1L-DGCR8_MTSS1L_chr16_70719625_ENST00000338779_DGCR8_chr22_20077498_ENST00000351989_length(transcript)=3406nt_BP=344nt
TACCGCCGCCGTCAGTCCCCGCGCCGAGGCTGCGCCGCGAGCTGCCCGCGCCGCGCCCCCCGCGCCGCCCGCCAGCCCCGCTGCGACATG
GCCCGCGCCGCCCGCCGGAGGCCCGCGACCCCGGAGCGCGGCGCGGCCGGCCGCTGAGCGCAGCCTGGAGGCGGGAGGCCCGGCCCGGCC
TCGGAGCGAGCGCCCGCGCGGCCTGGCCCCCTCCCTTGCGCTGCTCCCCGCGCTCCGTGCGCCTAGCCGCCGCCGCGGCCCGGCCCAGCC
AGAGCATGGAGACGGCGGAGAAGGAGTGCGGCGCCCTGGGCGGGCTCTTCCAGGCCATAGTCAACGACATGAAGAAACACGACCCTCCTC
TGAGTAGCATCCCTTGTCTGCATTATAAGAAAATGAAGGACAACGAGGAACGGGAGCAAAGCAGTGACCTCACCCCTAGTGGGGATGTGT
CCCCCGTCAAGCCCCTGAGCCGATCTGCAGAGCTGGAGTTTCCCCTGGATGAGCCTGACTCTATGGGTGCTGACCCGGGGCCCCCGGACG
AGAAAGACCCACTAGGGGCTGAGGCAGCCCCTGGGGCCCTGGGGCAGGTGAAGGCCAAAGTCGAGGTGTGCAAAGATGAATCCGTTGATC
TCGAGGAATTTCGAAGCTACCTGGAGAAGCGTTTTGACTTTGAGCAAGTTACTGTGAAAAAATTCAGGACTTGGGCTGAGCGGCGGCAAT
TCAATCGGGAAATGAAGCGGAAGCAGGCGGAGTCCGAGAGGCCCATCTTGCCAGCCAATCAGAAGCTCATTACTTTATCAGTGCAAGATG
CACCCACAAAGAAAGAGTTTGTTATTAACCCCAACGGGAAATCCGAGGTCTGCATCCTGCACGAGTACATGCAGCGTGTCCTCAAGGTCC
GCCCTGTCTATAATTTCTTTGAATGTGAGAACCCAAGTGAGCCTTTTGGTGCCTCGGTGACCATTGATGGTGTGACTTACGGATCTGGAA
CTGCAAGCAGCAAAAAACTTGCGAAGAATAAAGCTGCCCGAGCTACACTGGAAATCCTCATCCCTGACTTTGTTAAACAGACCTCTGAAG
AGAAGCCCAAAGACAGTGAAGAACTCGAGTATTTTAACCACATCAGCATCGAGGACTCGCGGGTCTACGAGCTGACCAGCAAGGCTGGGC
TGTTGTCTCCATATCAGATCCTCCACGAGTGCCTTAAAAGAAACCATGGGATGGGTGACACGTCTATCAAGTTTGAAGTGGTTCCTGGGA
AAAACCAGAAGAGTGAATACGTCATGGCGTGTGGCAAGCACACAGTGCGCGGGTGGTGTAAGAACAAGAGAGTTGGAAAGCAGTTAGCCT
CACAGAAGATCCTTCAGCTGCTGCACCCACATGTCAAGAACTGGGGGTCTTTACTGCGCATGTATGGCCGTGAGAGCAGCAAGATGGTCA
AGCAGGAGACATCGGACAAGAGTGTGATTGAGCTGCAGCAGTATGCCAAGAAGAACAAGCCCAACCTGCACATCCTCAGCAAGCTCCAAG
AGGAGATGAAGAGGCTAGCTGAGGAAAGGGAGGAGACTCGAAAGAAGCCCAAGATGTCCATTGTGGCGTCCGCCCAGCCTGGCGGTGAGC
CCCTGTGCACCGTGGACGTGTGAGGGAGGTGGCACGGGCCAGGGCGCGGGGGCCGCCAGCCGCACTTCTGAGGAGACCAGCAGTCATGCA
TCGTGCACCACAGTGTCAGGCCTCCAACCCACGCTCCTTCCCTGTGGCCAACCTGTGGGCCCGGCCTTAGGGTGGAGGCTTTAGTGTACA
GGGACAGCCATGGCCACACAGCACACATGTGGAGCAGCGGCTCTCCCTGGAAAGCTCCAGGCCTGAATGGATGGACTCAGCGACTGCACC
AGTGGCAGCTGGTGACTGTGGACAGTGGTGGACCCTGCTTCTGTGCACCTGCTGCAGGCTCTTTTTATGAAGGCTTTCATGAATTTTAGT
ATGTAATACGCACTGACGACACATGATGCTTGGATGACAGATGAGAGGGGATGGCTGAGTCCTGTGGCTGGCCCGTGATGCCAGGTGGCC
CATGTGCCCAGGGCGCCTGCAGGGCTGCTACAGGGACCTGGTCAGGAGGTGCACATGGTGCCCTGCCCTCACCCACCCTCTGTGTTTCCC
CTTCTTTGAAAAGGTAGAAGAGAAAGGAATATTTTAAACCTTTTTGGCTTAAACAGAATTTTAGCATCAGAACTAGCTTTCTGGGATTGG
AGGCAAACCATCAAGGTGGTCCCTCTCCAGTCTGGACACGATGCCAGCAAGGATGACGTCCTGCCACCTCCTGGAGTTACCCTGGCCTCC
TAGGGTCCCTTTTTCTGATGAAGTCTTAATTCCCTAAAAGCGCCTCTTTGGACACTGAGGCCCTCTCTGCCTTTCCTGGCCTCCGGCAAC
AGTTTTTTACAAAGATTTTTTGCAGTCGAGTCCATATGTCCACCCATTGATTTTTAAAGCTTTTGTGATATTTTAGCATTTTGAAAGACT
TTCACAGTGAGAGTAGAAGGTAGATTTGGAATCATGCATTTTAGCAAGTGGACTTGTTGAAACAGGAAGCAAGGGCCTTCAGTGTAGCCC
ATTCTTGATCCAGAGCTGTTGCCTGTGACAGCGGTTTCTCTGGATGTCAAAGGCAGCTGCCTGGTGCCCAGCTTGCTTCTCGACTGGTGG
CCCCTATGGGTGGGTGTGCGATGGAAATGTGTTCCTGCCGGAGTCTGAGGCACCAGGGTGTGCTCAAAGGCTGGCCCTGGTGGTGGACTG
GCACCTGTGCAGAGTGCCGTGTGCTTGTGGTGCGCCATCTGAAGCAAGAGTCCAGCGTTCTGCCGTGTCTGTCCCCCACCATGCCCCCTA
CAGGCGGTACTGATGGCGCTTTTTTTTTTTTTTCTGTCAGGAAAACAATGTTGGCCTGTGGGCCGCCCACAACATATCCTTCCCTCACTA
CCTGTGTGACCAAGGTTGGCTTCTGTTGACCTTTAAAAAAGAAACCCTCAACTCAAATTGCTATAATTAGACACTTGCTTCTGTCTTGCC
TCCTGTCTGCAGCTGTGAATAGTCATTTGACTGTGACTGTTGCCCTTAGCCAGCCAGATGCGCCTGTGAACCAAAGCTTCGTGCACATGT
GTTCCCCTAAAGGTTGGGGAGCCTCGCTGTGTCTTGCTGTTCCCAGGCACCACCACAGCAGGTGCTGCCATACTCTTGTGGTCTCTGTGC
GCCCCCCCCCCCCCCCCACCCGTCTGCCAAGCATGGGTATGAATCGTGCACACAGCCATGCTTCAAGGCCGGGGCAGGGGAGCCTGTGCT

>55914_55914_1_MTSS1L-DGCR8_MTSS1L_chr16_70719625_ENST00000338779_DGCR8_chr22_20077498_ENST00000351989_length(amino acids)=537AA_BP=37
MRRELPAPRPPRRPPAPLRHGPRRPPEARDPGARRGRPLSAAWRREARPGLGASARAAWPPPLRCSPRSVRLAAAAARPSQSMETAEKEC
GALGGLFQAIVNDMKKHDPPLSSIPCLHYKKMKDNEEREQSSDLTPSGDVSPVKPLSRSAELEFPLDEPDSMGADPGPPDEKDPLGAEAA
PGALGQVKAKVEVCKDESVDLEEFRSYLEKRFDFEQVTVKKFRTWAERRQFNREMKRKQAESERPILPANQKLITLSVQDAPTKKEFVIN
PNGKSEVCILHEYMQRVLKVRPVYNFFECENPSEPFGASVTIDGVTYGSGTASSKKLAKNKAARATLEILIPDFVKQTSEEKPKDSEELE
YFNHISIEDSRVYELTSKAGLLSPYQILHECLKRNHGMGDTSIKFEVVPGKNQKSEYVMACGKHTVRGWCKNKRVGKQLASQKILQLLHP

--------------------------------------------------------------
>55914_55914_2_MTSS1L-DGCR8_MTSS1L_chr16_70719625_ENST00000338779_DGCR8_chr22_20077498_ENST00000383024_length(transcript)=3311nt_BP=344nt
TACCGCCGCCGTCAGTCCCCGCGCCGAGGCTGCGCCGCGAGCTGCCCGCGCCGCGCCCCCCGCGCCGCCCGCCAGCCCCGCTGCGACATG
GCCCGCGCCGCCCGCCGGAGGCCCGCGACCCCGGAGCGCGGCGCGGCCGGCCGCTGAGCGCAGCCTGGAGGCGGGAGGCCCGGCCCGGCC
TCGGAGCGAGCGCCCGCGCGGCCTGGCCCCCTCCCTTGCGCTGCTCCCCGCGCTCCGTGCGCCTAGCCGCCGCCGCGGCCCGGCCCAGCC
AGAGCATGGAGACGGCGGAGAAGGAGTGCGGCGCCCTGGGCGGGCTCTTCCAGGCCATAGTCAACGACATGAAGAAACACGACCCTCCTC
TGAGTAGCATCCCTTGTCTGCATTATAAGAAAATGAAGGACAACGAGGAACGGGAGCAAAGCAGTGACCTCACCCCTAGTGGGGATGTGT
CCCCCGTCAAGCCCCTGAGCCGATCTGCAGAGCTGGAGTTTCCCCTGGATGAGCCTGACTCTATGGGTGCTGACCCGGGGCCCCCGGACG
AGAAAGACCCACTAGGGGCTGAGGCAGCCCCTGGGGCCCTGGGGCAGGTGAAGGCCAAAGTCGAGGTGTGCAAAGATGAATCCGTTGATC
TCGAGGAATTTCGAAGCTACCTGGAGAAGCGTTTTGACTTTGAGCAAGTTACTGTGAAAAAATTCAGGACTTGGGCTGAGCGGCGGCAAT
TCAATCGGGAAATGAAGCGGAAGCAGGCGGAGTCCGAGAGGCCCATCTTGCCAGCCAATCAGAAGCTCATTACTTTATCAGTGCAAGATG
CACCCACAAAGAAAGAGTTTGTTATTAACCCCAACGGGAAATCCGAGGTCTGCATCCTGCACGAGTACATGCAGCGTGTCCTCAAGGTCC
GCCCTGTCTATAATTTCTTTGAATGTGCCCGAGCTACACTGGAAATCCTCATCCCTGACTTTGTTAAACAGACCTCTGAAGAGAAGCCCA
AAGACAGTGAAGAACTCGAGTATTTTAACCACATCAGCATCGAGGACTCGCGGGTCTACGAGCTGACCAGCAAGGCTGGGCTGTTGTCTC
CATATCAGATCCTCCACGAGTGCCTTAAAAGAAACCATGGGATGGGTGACACGTCTATCAAGTTTGAAGTGGTTCCTGGGAAAAACCAGA
AGAGTGAATACGTCATGGCGTGTGGCAAGCACACAGTGCGCGGGTGGTGTAAGAACAAGAGAGTTGGAAAGCAGTTAGCCTCACAGAAGA
TCCTTCAGCTGCTGCACCCACATGTCAAGAACTGGGGGTCTTTACTGCGCATGTATGGCCGTGAGAGCAGCAAGATGGTCAAGCAGGAGA
CATCGGACAAGAGTGTGATTGAGCTGCAGCAGTATGCCAAGAAGAACAAGCCCAACCTGCACATCCTCAGCAAGCTCCAAGAGGAGATGA
AGAGGCTAGCTGAGGAAAGGGAGGAGACTCGAAAGAAGCCCAAGATGTCCATTGTGGCGTCCGCCCAGCCTGGCGGTGAGCCCCTGTGCA
CCGTGGACGTGTGAGGGAGGTGGCACGGGCCAGGGCGCGGGGGCCGCCAGCCGCACTTCTGAGGAGACCAGCAGTCATGCATCGTGCACC
ACAGTGTCAGGCCTCCAACCCACGCTCCTTCCCTGTGGCCAACCTGTGGGCCCGGCCTTAGGGTGGAGGCTTTAGTGTACAGGGACAGCC
ATGGCCACACAGCACACATGTGGAGCAGCGGCTCTCCCTGGAAAGCTCCAGGCCTGAATGGATGGACTCAGCGACTGCACCAGTGGCAGC
TGGTGACTGTGGACAGTGGTGGACCCTGCTTCTGTGCACCTGCTGCAGGCTCTTTTTATGAAGGCTTTCATGAATTTTAGTATGTAATAC
GCACTGACGACACATGATGCTTGGATGACAGATGAGAGGGGATGGCTGAGTCCTGTGGCTGGCCCGTGATGCCAGGTGGCCCATGTGCCC
AGGGCGCCTGCAGGGCTGCTACAGGGACCTGGTCAGGAGGTGCACATGGTGCCCTGCCCTCACCCACCCTCTGTGTTTCCCCTTCTTTGA
AAAGGTAGAAGAGAAAGGAATATTTTAAACCTTTTTGGCTTAAACAGAATTTTAGCATCAGAACTAGCTTTCTGGGATTGGAGGCAAACC
ATCAAGGTGGTCCCTCTCCAGTCTGGACACGATGCCAGCAAGGATGACGTCCTGCCACCTCCTGGAGTTACCCTGGCCTCCTAGGGTCCC
TTTTTCTGATGAAGTCTTAATTCCCTAAAAGCGCCTCTTTGGACACTGAGGCCCTCTCTGCCTTTCCTGGCCTCCGGCAACAGTTTTTTA
CAAAGATTTTTTGCAGTCGAGTCCATATGTCCACCCATTGATTTTTAAAGCTTTTGTGATATTTTAGCATTTTGAAAGACTTTCACAGTG
AGAGTAGAAGGTAGATTTGGAATCATGCATTTTAGCAAGTGGACTTGTTGAAACAGGAAGCAAGGGCCTTCAGTGTAGCCCATTCTTGAT
CCAGAGCTGTTGCCTGTGACAGCGGTTTCTCTGGATGTCAAAGGCAGCTGCCTGGTGCCCAGCTTGCTTCTCGACTGGTGGCCCCTATGG
GTGGGTGTGCGATGGAAATGTGTTCCTGCCGGAGTCTGAGGCACCAGGGTGTGCTCAAAGGCTGGCCCTGGTGGTGGACTGGCACCTGTG
CAGAGTGCCGTGTGCTTGTGGTGCGCCATCTGAAGCAAGAGTCCAGCGTTCTGCCGTGTCTGTCCCCCACCATGCCCCCTACAGGCGGTA
CTGATGGCGCTTTTTTTTTTTTTTCTGTCAGGAAAACAATGTTGGCCTGTGGGCCGCCCACAACATATCCTTCCCTCACTACCTGTGTGA
CCAAGGTTGGCTTCTGTTGACCTTTAAAAAAGAAACCCTCAACTCAAATTGCTATAATTAGACACTTGCTTCTGTCTTGCCTCCTGTCTG
CAGCTGTGAATAGTCATTTGACTGTGACTGTTGCCCTTAGCCAGCCAGATGCGCCTGTGAACCAAAGCTTCGTGCACATGTGTTCCCCTA
AAGGTTGGGGAGCCTCGCTGTGTCTTGCTGTTCCCAGGCACCACCACAGCAGGTGCTGCCATACTCTTGTGGTCTCTGTGCGCCCCCCCC
CCCCCCCCACCCGTCTGCCAAGCATGGGTATGAATCGTGCACACAGCCATGCTTCAAGGCCGGGGCAGGGGAGCCTGTGCTGATGCCATC

>55914_55914_2_MTSS1L-DGCR8_MTSS1L_chr16_70719625_ENST00000338779_DGCR8_chr22_20077498_ENST00000383024_length(amino acids)=504AA_BP=37
MRRELPAPRPPRRPPAPLRHGPRRPPEARDPGARRGRPLSAAWRREARPGLGASARAAWPPPLRCSPRSVRLAAAAARPSQSMETAEKEC
GALGGLFQAIVNDMKKHDPPLSSIPCLHYKKMKDNEEREQSSDLTPSGDVSPVKPLSRSAELEFPLDEPDSMGADPGPPDEKDPLGAEAA
PGALGQVKAKVEVCKDESVDLEEFRSYLEKRFDFEQVTVKKFRTWAERRQFNREMKRKQAESERPILPANQKLITLSVQDAPTKKEFVIN
PNGKSEVCILHEYMQRVLKVRPVYNFFECARATLEILIPDFVKQTSEEKPKDSEELEYFNHISIEDSRVYELTSKAGLLSPYQILHECLK
RNHGMGDTSIKFEVVPGKNQKSEYVMACGKHTVRGWCKNKRVGKQLASQKILQLLHPHVKNWGSLLRMYGRESSKMVKQETSDKSVIELQ

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>55914_55914_3_MTSS1L-DGCR8_MTSS1L_chr16_70719625_ENST00000338779_DGCR8_chr22_20077498_ENST00000407755_length(transcript)=3308nt_BP=344nt
TACCGCCGCCGTCAGTCCCCGCGCCGAGGCTGCGCCGCGAGCTGCCCGCGCCGCGCCCCCCGCGCCGCCCGCCAGCCCCGCTGCGACATG
GCCCGCGCCGCCCGCCGGAGGCCCGCGACCCCGGAGCGCGGCGCGGCCGGCCGCTGAGCGCAGCCTGGAGGCGGGAGGCCCGGCCCGGCC
TCGGAGCGAGCGCCCGCGCGGCCTGGCCCCCTCCCTTGCGCTGCTCCCCGCGCTCCGTGCGCCTAGCCGCCGCCGCGGCCCGGCCCAGCC
AGAGCATGGAGACGGCGGAGAAGGAGTGCGGCGCCCTGGGCGGGCTCTTCCAGGCCATAGTCAACGACATGAAGAAACACGACCCTCCTC
TGAGTAGCATCCCTTGTCTGCATTATAAGAAAATGAAGGACAACGAGGAACGGGAGCAAAGCAGTGACCTCACCCCTAGTGGGGATGTGT
CCCCCGTCAAGCCCCTGAGCCGATCTGCAGAGCTGGAGTTTCCCCTGGATGAGCCTGACTCTATGGGTGCTGACCCGGGGCCCCCGGACG
AGAAAGACCCACTAGGGGCTGAGGCAGCCCCTGGGGCCCTGGGGCAGGTGAAGGCCAAAGTCGAGGTGTGCAAAGATGAATCCGTTGATC
TCGAGGAATTTCGAAGCTACCTGGAGAAGCGTTTTGACTTTGAGCAAGTTACTGTGAAAAAATTCAGGACTTGGGCTGAGCGGCGGCAAT
TCAATCGGGAAATGAAGCGGAAGCAGGCGGAGTCCGAGAGGCCCATCTTGCCAGCCAATCAGAAGCTCATTACTTTATCAGTGCAAGATG
CACCCACAAAGAAAGAGTTTGTTATTAACCCCAACGGGAAATCCGAGGTCTGCATCCTGCACGAGTACATGCAGCGTGTCCTCAAGGTCC
GCCCTGTCTATAATTTCTTTGAATGTGCCCGAGCTACACTGGAAATCCTCATCCCTGACTTTGTTAAACAGACCTCTGAAGAGAAGCCCA
AAGACAGTGAAGAACTCGAGTATTTTAACCACATCAGCATCGAGGACTCGCGGGTCTACGAGCTGACCAGCAAGGCTGGGCTGTTGTCTC
CATATCAGATCCTCCACGAGTGCCTTAAAAGAAACCATGGGATGGGTGACACGTCTATCAAGTTTGAAGTGGTTCCTGGGAAAAACCAGA
AGAGTGAATACGTCATGGCGTGTGGCAAGCACACAGTGCGCGGGTGGTGTAAGAACAAGAGAGTTGGAAAGCAGTTAGCCTCACAGAAGA
TCCTTCAGCTGCTGCACCCACATGTCAAGAACTGGGGGTCTTTACTGCGCATGTATGGCCGTGAGAGCAGCAAGATGGTCAAGCAGGAGA
CATCGGACAAGAGTGTGATTGAGCTGCAGCAGTATGCCAAGAAGAACAAGCCCAACCTGCACATCCTCAGCAAGCTCCAAGAGGAGATGA
AGAGGCTAGCTGAGGAAAGGGAGGAGACTCGAAAGAAGCCCAAGATGTCCATTGTGGCGTCCGCCCAGCCTGGCGGTGAGCCCCTGTGCA
CCGTGGACGTGTGAGGGAGGTGGCACGGGCCAGGGCGCGGGGGCCGCCAGCCGCACTTCTGAGGAGACCAGCAGTCATGCATCGTGCACC
ACAGTGTCAGGCCTCCAACCCACGCTCCTTCCCTGTGGCCAACCTGTGGGCCCGGCCTTAGGGTGGAGGCTTTAGTGTACAGGGACAGCC
ATGGCCACACAGCACACATGTGGAGCAGCGGCTCTCCCTGGAAAGCTCCAGGCCTGAATGGATGGACTCAGCGACTGCACCAGTGGCAGC
TGGTGACTGTGGACAGTGGTGGACCCTGCTTCTGTGCACCTGCTGCAGGCTCTTTTTATGAAGGCTTTCATGAATTTTAGTATGTAATAC
GCACTGACGACACATGATGCTTGGATGACAGATGAGAGGGGATGGCTGAGTCCTGTGGCTGGCCCGTGATGCCAGGTGGCCCATGTGCCC
AGGGCGCCTGCAGGGCTGCTACAGGGACCTGGTCAGGAGGTGCACATGGTGCCCTGCCCTCACCCACCCTCTGTGTTTCCCCTTCTTTGA
AAAGGTAGAAGAGAAAGGAATATTTTAAACCTTTTTGGCTTAAACAGAATTTTAGCATCAGAACTAGCTTTCTGGGATTGGAGGCAAACC
ATCAAGGTGGTCCCTCTCCAGTCTGGACACGATGCCAGCAAGGATGACGTCCTGCCACCTCCTGGAGTTACCCTGGCCTCCTAGGGTCCC
TTTTTCTGATGAAGTCTTAATTCCCTAAAAGCGCCTCTTTGGACACTGAGGCCCTCTCTGCCTTTCCTGGCCTCCGGCAACAGTTTTTTA
CAAAGATTTTTTGCAGTCGAGTCCATATGTCCACCCATTGATTTTTAAAGCTTTTGTGATATTTTAGCATTTTGAAAGACTTTCACAGTG
AGAGTAGAAGGTAGATTTGGAATCATGCATTTTAGCAAGTGGACTTGTTGAAACAGGAAGCAAGGGCCTTCAGTGTAGCCCATTCTTGAT
CCAGAGCTGTTGCCTGTGACAGCGGTTTCTCTGGATGTCAAAGGCAGCTGCCTGGTGCCCAGCTTGCTTCTCGACTGGTGGCCCCTATGG
GTGGGTGTGCGATGGAAATGTGTTCCTGCCGGAGTCTGAGGCACCAGGGTGTGCTCAAAGGCTGGCCCTGGTGGTGGACTGGCACCTGTG
CAGAGTGCCGTGTGCTTGTGGTGCGCCATCTGAAGCAAGAGTCCAGCGTTCTGCCGTGTCTGTCCCCCACCATGCCCCCTACAGGCGGTA
CTGATGGCGCTTTTTTTTTTTTTTCTGTCAGGAAAACAATGTTGGCCTGTGGGCCGCCCACAACATATCCTTCCCTCACTACCTGTGTGA
CCAAGGTTGGCTTCTGTTGACCTTTAAAAAAGAAACCCTCAACTCAAATTGCTATAATTAGACACTTGCTTCTGTCTTGCCTCCTGTCTG
CAGCTGTGAATAGTCATTTGACTGTGACTGTTGCCCTTAGCCAGCCAGATGCGCCTGTGAACCAAAGCTTCGTGCACATGTGTTCCCCTA
AAGGTTGGGGAGCCTCGCTGTGTCTTGCTGTTCCCAGGCACCACCACAGCAGGTGCTGCCATACTCTTGTGGTCTCTGTGCGCCCCCCCC
CCCCCCCCACCCGTCTGCCAAGCATGGGTATGAATCGTGCACACAGCCATGCTTCAAGGCCGGGGCAGGGGAGCCTGTGCTGATGCCATC

>55914_55914_3_MTSS1L-DGCR8_MTSS1L_chr16_70719625_ENST00000338779_DGCR8_chr22_20077498_ENST00000407755_length(amino acids)=504AA_BP=37
MRRELPAPRPPRRPPAPLRHGPRRPPEARDPGARRGRPLSAAWRREARPGLGASARAAWPPPLRCSPRSVRLAAAAARPSQSMETAEKEC
GALGGLFQAIVNDMKKHDPPLSSIPCLHYKKMKDNEEREQSSDLTPSGDVSPVKPLSRSAELEFPLDEPDSMGADPGPPDEKDPLGAEAA
PGALGQVKAKVEVCKDESVDLEEFRSYLEKRFDFEQVTVKKFRTWAERRQFNREMKRKQAESERPILPANQKLITLSVQDAPTKKEFVIN
PNGKSEVCILHEYMQRVLKVRPVYNFFECARATLEILIPDFVKQTSEEKPKDSEELEYFNHISIEDSRVYELTSKAGLLSPYQILHECLK
RNHGMGDTSIKFEVVPGKNQKSEYVMACGKHTVRGWCKNKRVGKQLASQKILQLLHPHVKNWGSLLRMYGRESSKMVKQETSDKSVIELQ

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Fusion Gene PPI Analysis for MTSS1L-DGCR8

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	DGCR8	chr16:70719625	chr22:20077498	ENST00000351989		3	14	701_773	341.0	774.0	DROSHA
Tgene	DGCR8	chr16:70719625	chr22:20077498	ENST00000383024		3	13	701_773	341.0	741.0	DROSHA
Tgene	DGCR8	chr16:70719625	chr22:20077498	ENST00000407755		2	12	701_773	341.0	741.0	DROSHA

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MTSS1L-DGCR8

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MTSS1L-DGCR8

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source