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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MUC16-MUC16 (FusionGDB2 ID:55990)

Fusion Gene Summary for MUC16-MUC16

check button Fusion gene summary
Fusion gene informationFusion gene name: MUC16-MUC16
Fusion gene ID: 55990
HgeneTgene
Gene symbol

MUC16

MUC16

Gene ID

94025

94025

Gene namemucin 16, cell surface associatedmucin 16, cell surface associated
SynonymsCA125CA125
Cytomap

19p13.2

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionmucin-16CA125 ovarian cancer antigenmucin-16 long isoformmucin-16 short isoformovarian cancer-related tumor marker CA125ovarian carcinoma antigen CA125mucin-16CA125 ovarian cancer antigenmucin-16 long isoformmucin-16 short isoformovarian cancer-related tumor marker CA125ovarian carcinoma antigen CA125
Modification date2020032920200329
UniProtAcc

Q8WXI7

Q8WXI7

Ensembl transtripts involved in fusion geneENST00000380951, ENST00000397910, 
ENST00000596956, 		ENST00000380951, 
ENST00000397910, ENST00000596956, 
Fusion gene scores* DoF score12 X 24 X 4=11522 X 5 X 1=10
# samples 215
** MAII scorelog2(21/1152*10)=-2.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/10*10)=2.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MUC16 [Title/Abstract] AND MUC16 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMUC16(9008230)-MUC16(9047350), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MUC16 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MUC16 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA640762MUC16chr19

9000482

-MUC16chr19

8999456

+
ChiTaRS5.0N/ADL070218MUC16chr19

9008230

-MUC16chr19

9047350

-
ChiTaRS5.0N/ADL070223MUC16chr19

8959585

-MUC16chr19

8976280

-
ChiTaRS5.0N/ADL070242MUC16chr19

8999456

-MUC16chr19

9000482

+
ChiTaRS5.0N/ADL070246MUC16chr19

9008230

-MUC16chr19

9047350

-


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Fusion Gene ORF analysis for MUC16-MUC16

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000380951ENST00000380951MUC16chr19

9000482

-MUC16chr19

8999456

+
intron-3CDSENST00000380951ENST00000380951MUC16chr19

8959585

-MUC16chr19

8976280

-
intron-3CDSENST00000380951ENST00000380951MUC16chr19

8999456

-MUC16chr19

9000482

+
intron-3CDSENST00000380951ENST00000397910MUC16chr19

9000482

-MUC16chr19

8999456

+
intron-3CDSENST00000380951ENST00000397910MUC16chr19

9008230

-MUC16chr19

9047350

-
intron-3CDSENST00000380951ENST00000397910MUC16chr19

8959585

-MUC16chr19

8976280

-
intron-3CDSENST00000380951ENST00000397910MUC16chr19

8999456

-MUC16chr19

9000482

+
intron-3CDSENST00000397910ENST00000380951MUC16chr19

9000482

-MUC16chr19

8999456

+
intron-3CDSENST00000397910ENST00000380951MUC16chr19

8959585

-MUC16chr19

8976280

-
intron-3CDSENST00000397910ENST00000380951MUC16chr19

8999456

-MUC16chr19

9000482

+
intron-3CDSENST00000397910ENST00000397910MUC16chr19

9000482

-MUC16chr19

8999456

+
intron-3CDSENST00000397910ENST00000397910MUC16chr19

9008230

-MUC16chr19

9047350

-
intron-3CDSENST00000397910ENST00000397910MUC16chr19

8959585

-MUC16chr19

8976280

-
intron-3CDSENST00000397910ENST00000397910MUC16chr19

8999456

-MUC16chr19

9000482

+
intron-3CDSENST00000596956ENST00000380951MUC16chr19

9000482

-MUC16chr19

8999456

+
intron-3CDSENST00000596956ENST00000380951MUC16chr19

8959585

-MUC16chr19

8976280

-
intron-3CDSENST00000596956ENST00000380951MUC16chr19

8999456

-MUC16chr19

9000482

+
intron-3CDSENST00000596956ENST00000397910MUC16chr19

9000482

-MUC16chr19

8999456

+
intron-3CDSENST00000596956ENST00000397910MUC16chr19

9008230

-MUC16chr19

9047350

-
intron-3CDSENST00000596956ENST00000397910MUC16chr19

8959585

-MUC16chr19

8976280

-
intron-3CDSENST00000596956ENST00000397910MUC16chr19

8999456

-MUC16chr19

9000482

+
intron-intronENST00000380951ENST00000380951MUC16chr19

9008230

-MUC16chr19

9047350

-
intron-intronENST00000380951ENST00000596956MUC16chr19

9000482

-MUC16chr19

8999456

+
intron-intronENST00000380951ENST00000596956MUC16chr19

9008230

-MUC16chr19

9047350

-
intron-intronENST00000380951ENST00000596956MUC16chr19

8959585

-MUC16chr19

8976280

-
intron-intronENST00000380951ENST00000596956MUC16chr19

8999456

-MUC16chr19

9000482

+
intron-intronENST00000397910ENST00000380951MUC16chr19

9008230

-MUC16chr19

9047350

-
intron-intronENST00000397910ENST00000596956MUC16chr19

9000482

-MUC16chr19

8999456

+
intron-intronENST00000397910ENST00000596956MUC16chr19

9008230

-MUC16chr19

9047350

-
intron-intronENST00000397910ENST00000596956MUC16chr19

8959585

-MUC16chr19

8976280

-
intron-intronENST00000397910ENST00000596956MUC16chr19

8999456

-MUC16chr19

9000482

+
intron-intronENST00000596956ENST00000380951MUC16chr19

9008230

-MUC16chr19

9047350

-
intron-intronENST00000596956ENST00000596956MUC16chr19

9000482

-MUC16chr19

8999456

+
intron-intronENST00000596956ENST00000596956MUC16chr19

9008230

-MUC16chr19

9047350

-
intron-intronENST00000596956ENST00000596956MUC16chr19

8959585

-MUC16chr19

8976280

-
intron-intronENST00000596956ENST00000596956MUC16chr19

8999456

-MUC16chr19

9000482

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MUC16-MUC16


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MUC16-MUC16


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:9008230/:9047350)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MUC16

Q8WXI7

MUC16

Q8WXI7

FUNCTION: Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}.FUNCTION: Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MUC16-MUC16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MUC16-MUC16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MUC16-MUC16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MUC16-MUC16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource