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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MUC2-KIRREL3 (FusionGDB2 ID:56022)

Fusion Gene Summary for MUC2-KIRREL3

Fusion gene summary

Fusion gene information	Fusion gene name: MUC2-KIRREL3
	Fusion gene ID: 56022
		Hgene	Tgene
	Gene symbol	MUC2	KIRREL3
	Gene ID	4583	84623
	Gene name	mucin 2, oligomeric mucus/gel-forming	kirre like nephrin family adhesion molecule 3
	Synonyms	MLP\|MUC-2\|SMUC	KIRRE\|MRD4\|NEPH2\|PRO4502
	Cytomap	11p15.5	11q24.2
	Type of gene	protein-coding	protein-coding
	Description	mucin-2mucin 2, intestinal/tracheal	kin of IRRE-like protein 3kin of IRRE like 3kin of irregular chiasm-like protein 3nephrin-like 2nephrin-like protein 2
	Modification date	20200320	20200313
	UniProtAcc	Q02817	Q8IZU9
	Ensembl transtripts involved in fusion gene	ENST00000359061, ENST00000441003, ENST00000333592, ENST00000361558,	ENST00000416561, ENST00000525704, ENST00000533026, ENST00000525144, ENST00000529097,
Fusion gene scores	* DoF score	9 X 9 X 4=324	11 X 8 X 4=352
	# samples	9	10
	** MAII score	log2(9/324*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/352*10)=-1.81557542886257 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MUC2 [Title/Abstract] AND KIRREL3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MUC2(1092801)-KIRREL3(126294560), # samples:1
Anticipated loss of major functional domain due to fusion event.	MUC2-KIRREL3 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. MUC2-KIRREL3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MUC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KIRREL3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	COAD	TCGA-AA-3518-01A	MUC2	chr11	1092801	+	KIRREL3	chr11	126294560	-

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Fusion Gene ORF analysis for MUC2-KIRREL3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000359061	ENST00000416561	MUC2	chr11	1092801	+	KIRREL3	chr11	126294560	-
5CDS-intron	ENST00000359061	ENST00000525704	MUC2	chr11	1092801	+	KIRREL3	chr11	126294560	-
5CDS-intron	ENST00000359061	ENST00000533026	MUC2	chr11	1092801	+	KIRREL3	chr11	126294560	-
5CDS-intron	ENST00000441003	ENST00000416561	MUC2	chr11	1092801	+	KIRREL3	chr11	126294560	-
5CDS-intron	ENST00000441003	ENST00000525704	MUC2	chr11	1092801	+	KIRREL3	chr11	126294560	-
5CDS-intron	ENST00000441003	ENST00000533026	MUC2	chr11	1092801	+	KIRREL3	chr11	126294560	-
Frame-shift	ENST00000359061	ENST00000525144	MUC2	chr11	1092801	+	KIRREL3	chr11	126294560	-
Frame-shift	ENST00000359061	ENST00000529097	MUC2	chr11	1092801	+	KIRREL3	chr11	126294560	-
Frame-shift	ENST00000441003	ENST00000525144	MUC2	chr11	1092801	+	KIRREL3	chr11	126294560	-
In-frame	ENST00000441003	ENST00000529097	MUC2	chr11	1092801	+	KIRREL3	chr11	126294560	-
intron-3CDS	ENST00000333592	ENST00000525144	MUC2	chr11	1092801	+	KIRREL3	chr11	126294560	-
intron-3CDS	ENST00000333592	ENST00000529097	MUC2	chr11	1092801	+	KIRREL3	chr11	126294560	-
intron-3CDS	ENST00000361558	ENST00000525144	MUC2	chr11	1092801	+	KIRREL3	chr11	126294560	-
intron-3CDS	ENST00000361558	ENST00000529097	MUC2	chr11	1092801	+	KIRREL3	chr11	126294560	-
intron-intron	ENST00000333592	ENST00000416561	MUC2	chr11	1092801	+	KIRREL3	chr11	126294560	-
intron-intron	ENST00000333592	ENST00000525704	MUC2	chr11	1092801	+	KIRREL3	chr11	126294560	-
intron-intron	ENST00000333592	ENST00000533026	MUC2	chr11	1092801	+	KIRREL3	chr11	126294560	-
intron-intron	ENST00000361558	ENST00000416561	MUC2	chr11	1092801	+	KIRREL3	chr11	126294560	-
intron-intron	ENST00000361558	ENST00000525704	MUC2	chr11	1092801	+	KIRREL3	chr11	126294560	-
intron-intron	ENST00000361558	ENST00000533026	MUC2	chr11	1092801	+	KIRREL3	chr11	126294560	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000441003

MUC2

chr11

1092801

ENST00000529097

KIRREL3

chr11

126294560

6228

5057

4841

1608

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000441003	ENST00000529097	MUC2	chr11	1092801	+	KIRREL3	chr11	126294560	-	0.00130668	0.9986933

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Fusion Genomic Features for MUC2-KIRREL3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MUC2-KIRREL3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:1092801/chr11:126294560)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MUC2 Q02817	KIRREL3 Q8IZU9
FUNCTION: Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer. {ECO:0000269\|PubMed:19432394}.	FUNCTION: Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells. {ECO:0000250\|UniProtKB:Q8BR86}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

KIRREL3

chr11:1092801

chr11:126294560

ENST00000525144

701_767

779.0

Compositional bias

Note=Ser-rich

Tgene

KIRREL3

chr11:1092801

chr11:126294560

ENST00000525704

701_767

601.0

Compositional bias

Note=Ser-rich

Tgene

KIRREL3

chr11:1092801

chr11:126294560

ENST00000525144

147_243

779.0

Domain

Note=Ig-like C2-type 2

Tgene

KIRREL3

chr11:1092801

chr11:126294560

ENST00000525144

249_330

779.0

Domain

Note=Ig-like C2-type 3

Tgene

KIRREL3

chr11:1092801

chr11:126294560

ENST00000525144

335_415

779.0

Domain

Note=Ig-like C2-type 4

Tgene

KIRREL3

chr11:1092801

chr11:126294560

ENST00000525144

419_515

779.0

Domain

Note=Ig-like C2-type 5

Tgene

KIRREL3

chr11:1092801

chr11:126294560

ENST00000525144

48_142

779.0

Domain

Note=Ig-like C2-type 1

Tgene

KIRREL3

chr11:1092801

chr11:126294560

ENST00000525704

147_243

601.0

Domain

Note=Ig-like C2-type 2

Tgene

KIRREL3

chr11:1092801

chr11:126294560

ENST00000525704

249_330

601.0

Domain

Note=Ig-like C2-type 3

Tgene

KIRREL3

chr11:1092801

chr11:126294560

ENST00000525704

335_415

601.0

Domain

Note=Ig-like C2-type 4

Tgene

KIRREL3

chr11:1092801

chr11:126294560

ENST00000525704

419_515

601.0

Domain

Note=Ig-like C2-type 5

Tgene

KIRREL3

chr11:1092801

chr11:126294560

ENST00000525704

48_142

601.0

Domain

Note=Ig-like C2-type 1

Tgene

KIRREL3

chr11:1092801

chr11:126294560

ENST00000525144

22_535

779.0

Topological domain

Extracellular

Tgene

KIRREL3

chr11:1092801

chr11:126294560

ENST00000525144

557_778

779.0

Topological domain

Cytoplasmic

Tgene

KIRREL3

chr11:1092801

chr11:126294560

ENST00000525704

22_535

601.0

Topological domain

Extracellular

Tgene

KIRREL3

chr11:1092801

chr11:126294560

ENST00000525704

557_778

601.0

Topological domain

Cytoplasmic

Tgene

KIRREL3

chr11:1092801

chr11:126294560

ENST00000525144

536_556

779.0

Transmembrane

Helical

Tgene

KIRREL3

chr11:1092801

chr11:126294560

ENST00000525704

536_556

601.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

295_351

1780.0

Domain

Note=TIL

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

36_240

1780.0

Domain

VWFD 1

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

390_604

1780.0

Domain

VWFD 2

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

4480_4690

1780.0

Domain

VWFD 4

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

4815_4886

1780.0

Domain

VWFC 1

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

4924_4991

1780.0

Domain

VWFC 2

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

5075_5160

1780.0

Domain

CTCK

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

859_1065

1780.0

Domain

VWFD 3

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

1401_1747

1780.0

Region

Note=Approximate repeats

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

1401_1416

1780.0

Repeat

Note=1

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

1417_1432

1780.0

Repeat

Note=2

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

1433_1448

1780.0

Repeat

Note=3

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

1449_1464

1780.0

Repeat

Note=4

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

1465_1471

1780.0

Repeat

Note=5

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

1472_1478

1780.0

Repeat

Note=6

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

1479_1494

1780.0

Repeat

Note=7A

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

1495_1517

1780.0

Repeat

Note=7B

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

1518_1533

1780.0

Repeat

Note=8A

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

1534_1556

1780.0

Repeat

Note=8B

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

1557_1572

1780.0

Repeat

Note=9A

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

1573_1596

1780.0

Repeat

Note=9B

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

1597_1612

1780.0

Repeat

Note=10A

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

1613_1635

1780.0

Repeat

Note=10B

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

1636_1651

1780.0

Repeat

Note=11A

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

1652_1675

1780.0

Repeat

Note=11B

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

1676_1683

1780.0

Repeat

Note=12

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

1684_1699

1780.0

Repeat

Note=13

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

1700_1715

1780.0

Repeat

Note=14

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

1716_1731

1780.0

Repeat

Note=15

Hgene

MUC2

chr11:1092801

chr11:126294560

ENST00000359061

1732_1747

1780.0

Repeat

Note=16

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Fusion Gene Sequence for MUC2-KIRREL3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>56022_56022_1_MUC2-KIRREL3_MUC2_chr11_1092801_ENST00000441003_KIRREL3_chr11_126294560_ENST00000529097_length(transcript)=6228nt_BP=5057nt
CAACCCACACCGCCCCTGCCAGCCACCATGGGGCTGCCACTAGCCCGCCTGGCGGCTGTGTGCCTGGCCCTGTCTTTGGCAGGGGGCTCG
GAGCTCCAGACAGAGGGCAGAACCCGAAACCACGGCCACAACGTCTGCAGCACCTGGGGCAACTTCCACTACAAGACCTTCGACGGGGAC
GTCTTCCGCTTCCCCGGCCTCTGCGACTACAACTTCGCCTCCGACTGCCGAGGCTCCTACAAGGAATTTGCTGTGCACCTGAAGCGGGGT
CCGGGCCAGGCTGAGGCCCCCGCCGGGGTGGAGTCCATCCTGCTGACCATCAAGGATGACACCATCTACCTCACCCGCCACCTGGCTGTG
CTTAACGGGGCCGTGGTCAGCACCCCGCACTACAGCCCCGGGCTGCTCATTGAGAAGAGCGATGCCTACACCAAAGTCTACTCCCGCGCC
GGCCTCACCCTCATGTGGAACCGGGAGGATGCACTCATGCTGGAGCTGGACACTAAGTTCCGGAACCACACCTGTGGCCTCTGCGGGGAC
TACAACGGCCTGCAGAGCTATTCAGAATTCCTCTCTGACGGCGTGCTCTTCAGTCCCCTGGAGTTTGGGAACATGCAGAAGATCAACCAG
CCCGATGTGGTGTGTGAGGATCCCGAGGAGGAGGTGGCCCCCGCATCCTGCTCCGAGCACCGCGCCGAGTGTGAGAGGCTGCTGACCGCC
GAGGCCTTCGCGGACTGTCAGGACCTGGTGCCGCTGGAGCCGTATCTGCGCGCCTGCCAGCAGGACCGCTGCCGGTGCCCGGGCGGTGAC
ACCTGCGTCTGCAGCACCGTGGCCGAGTTCTCCCGCCAGTGCTCCCACGCCGGCGGCCGGCCCGGGAACTGGAGGACCGCCACGCTCTGC
CCCAAGACCTGCCCCGGGAACCTGGTGTACCTGGAGAGCGGCTCGCCCTGCATGGACACCTGCTCACACCTGGAGGTGAGCAGCCTGTGC
GAGGAGCACCGCATGGACGGCTGTTTCTGCCCAGAAGGCACCGTATATGACGACATCGGGGACAGTGGCTGCGTTCCTGTGAGCCAGTGC
CACTGCAGGCTGCACGGACACCTGTACACACCGGGCCAGGAGATCACCAATGACTGCGAGCAGTGTGTCTGTAACGCTGGCCGCTGGGTG
TGCAAAGACCTGCCCTGCCCCGGCACCTGTGCCCTGGAAGGCGGCTCCCACATCACCACCTTCGATGGGAAGACGTACACCTTCCACGGG
GACTGCTACTATGTCCTGGCCAAGGGTGACCACAACGATTCCTACGCTCTCCTGGGCGAGCTGGCCCCCTGTGGCTCCACAGACAAGCAG
ACCTGCCTGAAGACGGTGGTGCTGCTGGCTGACAAGAAGAAGAATGTGGTGGTCTTCAAGTCCGATGGCAGTGTACTGCTCAACGAGCTG
CAGGTGAACCTGCCCCACGTGACCGCGAGCTTCTCTGTCTTCCGCCCGTCTTCCTACCACATCATGGTGAGCATGGCCATTGGCGTCCGG
CTGCAGGTGCAGCTGGCCCCAGTCATGCAACTCTTTGTGACACTGGACCAGGCCTCCCAGGGGCAGGTGCAGGGCCTCTGCGGGAACTTC
AACGGCCTGGAAGGTGACGACTTCAAGACGGCCAGCGGGCTGGTGGAGGCCACGGGGGCCGGCTTTGCCAACACCTGGAAGGCACAGTCA
AGCTGCCATGACAAGCTGGACTGGTTGGACGATCCCTGCTCCCTGAACATCGAGAGCGCCAACTACGCCGAGCACTGGTGCTCCCTCCTG
AAGAAGACAGAGACCCCCTTTGGCAGGTGCCACTCGGCTGTGGACCCTGCTGAGTATTACAAGAGGTGCAAATATGACACGTGTAACTGT
CAGAACAATGAGGACTGCCTGTGCGCCGCCCTGTCCTCCTACGCGCGCGCCTGCACCGCCAAGGGCGTCATGCTGTGGGGCTGGCGGGAG
CATGTCTGCAACAAGGATGTGGGCTCCTGCCCCAACTCGCAGGTCTTCCTGTACAACCTGACCACCTGCCAGCAGACCTGCCGCTCCCTC
TCCGAGGCCGACAGCCACTGTCTCGAGGGCTTTGCGCCTGTGGACGGCTGCGGCTGCCCTGACCACACCTTCCTGGACGAGAAGGGCCGC
TGCGTACCCCTGGCCAAGTGCTCCTGTTACCACCGCGGTCTCTACCTGGAGGCGGGGGATGTGGTCGTCAGGCAGGAAGAACGATGTGTG
TGCCGGGATGGGCGGCTGCACTGTAGGCAGATCCGGCTGATCGGCCAGAGCTGCACGGCCCCAAAGATCCACATGGACTGCAGCAACCTG
ACTGCACTGGCCACCTCGAAGCCCCGAGCCCTCAGCTGCCAGACGCTGGCCGCCGGCTATTACCACACAGAGTGTGTCAGTGGCTGTGTG
TGCCCCGACGGGCTGATGGATGACGGCCGGGGTGGCTGCGTGGTGGAGAAGGAATGCCCTTGCGTCCATAACAACGACCTGTATTCTTCC
GGCGCCAAGATCAAGGTGGACTGCAATACCTGCACCTGCAAGAGAGGACGCTGGGTGTGCACCCAGGCTGTGTGCCATGGCACCTGCTCC
ATTTACGGGAGTGGCCACTACATCACCTTTGATGGGAAGTACTACGACTTTGACGGACACTGCTCCTACGTGGCTGTTCAGGACTACTGC
GGCCAGAACTCCTCACTGGGCTCATTCAGCATCATCACCGAGAACGTCCCCTGTGGCACTACGGGCGTCACCTGCTCCAAGGCCATCAAG
ATCTTCATGGGGAGGACGGAGCTGAAGTTGGAAGACAAGCACCGTGTGGTGATCCAGCGTGATGAGGGTCACCACGTGGCCTACACCACG
CGGGAGGTGGGCCAGTACCTGGTGGTGGAGTCCAGCACGGGCATCATCGTCATCTGGGACAAGAGGACCACCGTGTTCATCAAGCTGGCT
CCCTCCTACAAGGGCACCGTGTGTGGCCTGTGTGGGAACTTTGACCACCGCTCCAACAACGACTTCACCACGCGGGACCACATGGTGGTG
AGCAGCGAGCTGGACTTCGGGAACAGCTGGAAGGAGGCCCCCACCTGCCCAGATGTGAGCACCAACCCCGAGCCCTGCAGCCTGAACCCG
CACCGCCGCTCCTGGGCCGAGAAGCAGTGCAGCATCCTCAAAAGCAGCGTGTTCAGCATCTGCCACAGCAAGGTGGACCCCAAGCCCTTC
TACGAGGCCTGTGTGCACGACTCGTGCTCCTGTGACACGGGTGGGGACTGTGAGTGCTTCTGCTCTGCCGTGGCCTCCTACGCCCAGGAG
TGTACCAAAGAGGGGGCCTGCGTGTTCTGGAGGACGCCGGACCTGTGCCCCATATTCTGCGACTACTACAACCCTCCGCATGAGTGTGAG
TGGCACTATGAGCCATGTGGGAACCGGAGCTTCGAGACCTGCAGGACCATCAACGGCATCCACTCCAACATCTCCGTGTCCTACCTGGAG
GGCTGCTACCCCCGGTGCCCCAAGGACAGGCCCATCTATGAGGAGGATCTGAAGAAGTGTGTCACTGCAGACAAGTGTGGCTGCTATGTC
GAGGACACCCACTACCCACCTGGAGCATCGGTTCCCACCGAGGAGACCTGCAAGTCCTGCGTGTGTACCAACTCCTCCCAAGTCGTCTGC
AGGCCGGAGGAAGGAAAGATTCTTAACCAGACCCAGGATGGCGCCTTCTGCTACTGGGAGATCTGTGGCCCCAACGGGACGGTGGAGAAG
CACTTCAACATCTGTTCCATTACGACACGCCCGTCCACCCTGACCACCTTCACCACCATCACCCTCCCCACCACCCCCACCACCTTCACC
ACTACCACCACCACCACCACCCCGACCTCCAGCACAGTTTTATCAACAACTCCGAACCACCACCACCACGGTGACCCCAACCCCAACACC
CACCGGCACACAGACCCCAACAACGACACCCATCACCACCACCACCACGGTGACCCCAACCCCAACACCCACCGGCACACAGACCCCAAC
ATCGACACCCATCACCACCACCACTACGGTGACCCCAACCCCAACACCCACCGGCACACAGACCCCAACCACGACACCCATCACCACCAC
CACTACGGTGACCCCAACCCCAACACCCACTGGCACACAGACCCCAACCCCAACAGCCATCACCACCACCACTACGGTGACCCCAACCCC
AACACCCACCGGCACACAGACCCCAACCACGACACCCATCACCACCACCACTACGGTGACACCAACCCCAACACCCACCGGCACACAGTC
CCCAACCCCAACAGCCATCACCACCACCACTACGGTGACCCCAACCCCAACACCCACCGGCACACAGACCCCAACATCGACACCCATCAC
CACCACCACTACGGTGACCCCAACCCCAACACCCACCGGCACACAGACCCCAACCCCGACACCCATCTCCACCACCACTACGGTGACCCC
AACCCCAACACCCACCGGCACACAGACCCCAACCACGACACCCATCACCACCACCACCACGGTGACCCCAACCCCGACACCCACCGGCAC
ACAGACCCCAACCACGGTACTCATCACCACCACCACTACGATGACCCCAACCCCAACACCCACCAGCACAAAGAGTACAACCGTGACACC
CATCACCACCACAACTACGGTGACCGCAACCCCAACACCCACCGGCACACAGACCCCAACCATGATACCCATCAGCACCACCACTACGGT
GACCCCAACCCCAACACCCACCACTGGAAGCACGGGGCCCCCCACCCACACAAGCACAGCACCCATTGCTGAGTTGACCACATCCAATCC
TCCGCCTGAGTCCTCAACCCCTCAGACCTCTCGGTCCACCTCTTCCCCTCTCACGGAGTCAACCACCCTTCTGAGTACCCTACCACCTGC
CATTGAGATGACCAGCACGGCCCCACCCTCCACACCCACGGCACCCACGACCACGAGCGGAGGCCACACACTGTCTCCACCGCCCAGCAC
CACCACGTCCCCTCCAGCTTCCTCCTCCCACCACTCCCAGTCCTCGTCCCAGAACTCTGACCCCAGTCGACCCCTGCAGCGGCGGATGCA
GACTCACGTCTAAGGATCACACACCGCGGGTGGGGACGGGCCAGGGAAGAGGTCAGGGCACGTTCTGGTTGTCCAGGGACGAGGGGTACT
TTGCAGAGGACACCAGAATTGGCCACTTCCAGGACAGCCTCCCAGCGCCTCTGCCACTGCCTTCCTTCGAAGCTCTGATCAAGCACAAAT
CTGGGTCCCCAGGTGCTGTGTGCCAGAGGTGGGCGGGTGGGGAGACAGACAGAGGCTGCGGCTGAGTGCGCTGTGCTTAGTGCTGGACAC
CCGTGTCCCCGGCCCTTTCCTGGAGGCCCCTCTACCACCTGCTCTGCCCACAGGCACAAGTGGCAGCTATAACTCTGCTTTCATGAAACT
GCGGTCCACTCTCTGGTCTCTCTGTGGGCTCTACCCCTCGCTGACCAGAAGCTCTACCTACCCCTGTGCCTGTGCTCCCATACAGCCCTG
GGGAGAAGGGGATGACGTCTTCCCAGCACTGAGCTGCCCCAGAAACCCCGGCTCCCCACTGCTGCTCATAGCCCATACCCTGGAGGCTGA
CAAGCCAGAAATGGCCTTGGCTAAAGGAGCCTCTCTCTCACCAGGCTGGCCGGGAGCCCACCCCCAATTTGTTTGGTGTTTTGTGTCCAT
ACTCTTGCAGTTCTGTCCTTGGACTTGATGCCGCTGAACTCTGCGGTGGGACCGGTCCGGTCAGAGCCTGGTGTACTGGGGGGAGGGAGG
GAGGAGGGAGCCTGTGCTGACGGAGCACCTCGCCGGGTGTGCCCCTCCTGGGCTGTGTGACCCCAGCCTCCCCACCCACCTCCTGCTTTG
TGTACTCCTCCCCTCCCCCTCAGCACAATCGGAGTTCATATAAGAAGTGCGGGAGCTTCTCTGGTCAGGGTTCTCTGAACACTTATGGAG
AGAGTGCTTCCTGGGAAGTGTGGCGTTTGAAGGGGCTGGAGGGCAGGTCTTTAAGATGGCGAGACTGCCCTTCTCAGCTGATAAACACAA
GAACGGCGATCCTGTCTTCAGTAAGGCTCCACGAGAAGAGAGGAAGTATATCTACACCTCAACCCTCCTAGTCACCACCTGAAATAAATG

>56022_56022_1_MUC2-KIRREL3_MUC2_chr11_1092801_ENST00000441003_KIRREL3_chr11_126294560_ENST00000529097_length(amino acids)=1608AA_BP=
MPATMGLPLARLAAVCLALSLAGGSELQTEGRTRNHGHNVCSTWGNFHYKTFDGDVFRFPGLCDYNFASDCRGSYKEFAVHLKRGPGQAE
APAGVESILLTIKDDTIYLTRHLAVLNGAVVSTPHYSPGLLIEKSDAYTKVYSRAGLTLMWNREDALMLELDTKFRNHTCGLCGDYNGLQ
SYSEFLSDGVLFSPLEFGNMQKINQPDVVCEDPEEEVAPASCSEHRAECERLLTAEAFADCQDLVPLEPYLRACQQDRCRCPGGDTCVCS
TVAEFSRQCSHAGGRPGNWRTATLCPKTCPGNLVYLESGSPCMDTCSHLEVSSLCEEHRMDGCFCPEGTVYDDIGDSGCVPVSQCHCRLH
GHLYTPGQEITNDCEQCVCNAGRWVCKDLPCPGTCALEGGSHITTFDGKTYTFHGDCYYVLAKGDHNDSYALLGELAPCGSTDKQTCLKT
VVLLADKKKNVVVFKSDGSVLLNELQVNLPHVTASFSVFRPSSYHIMVSMAIGVRLQVQLAPVMQLFVTLDQASQGQVQGLCGNFNGLEG
DDFKTASGLVEATGAGFANTWKAQSSCHDKLDWLDDPCSLNIESANYAEHWCSLLKKTETPFGRCHSAVDPAEYYKRCKYDTCNCQNNED
CLCAALSSYARACTAKGVMLWGWREHVCNKDVGSCPNSQVFLYNLTTCQQTCRSLSEADSHCLEGFAPVDGCGCPDHTFLDEKGRCVPLA
KCSCYHRGLYLEAGDVVVRQEERCVCRDGRLHCRQIRLIGQSCTAPKIHMDCSNLTALATSKPRALSCQTLAAGYYHTECVSGCVCPDGL
MDDGRGGCVVEKECPCVHNNDLYSSGAKIKVDCNTCTCKRGRWVCTQAVCHGTCSIYGSGHYITFDGKYYDFDGHCSYVAVQDYCGQNSS
LGSFSIITENVPCGTTGVTCSKAIKIFMGRTELKLEDKHRVVIQRDEGHHVAYTTREVGQYLVVESSTGIIVIWDKRTTVFIKLAPSYKG
TVCGLCGNFDHRSNNDFTTRDHMVVSSELDFGNSWKEAPTCPDVSTNPEPCSLNPHRRSWAEKQCSILKSSVFSICHSKVDPKPFYEACV
HDSCSCDTGGDCECFCSAVASYAQECTKEGACVFWRTPDLCPIFCDYYNPPHECEWHYEPCGNRSFETCRTINGIHSNISVSYLEGCYPR
CPKDRPIYEEDLKKCVTADKCGCYVEDTHYPPGASVPTEETCKSCVCTNSSQVVCRPEEGKILNQTQDGAFCYWEICGPNGTVEKHFNIC
SITTRPSTLTTFTTITLPTTPTTFTTTTTTTTPTSSTVLSTTPNHHHHGDPNPNTHRHTDPNNDTHHHHHHGDPNPNTHRHTDPNIDTHH
HHHYGDPNPNTHRHTDPNHDTHHHHHYGDPNPNTHWHTDPNPNSHHHHHYGDPNPNTHRHTDPNHDTHHHHHYGDTNPNTHRHTVPNPNS
HHHHHYGDPNPNTHRHTDPNIDTHHHHHYGDPNPNTHRHTDPNPDTHLHHHYGDPNPNTHRHTDPNHDTHHHHHHGDPNPDTHRHTDPNH

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Fusion Gene PPI Analysis for MUC2-KIRREL3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MUC2-KIRREL3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MUC2-KIRREL3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source