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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MUM1-ALB (FusionGDB2 ID:56057)

Fusion Gene Summary for MUM1-ALB

check button Fusion gene summary
Fusion gene informationFusion gene name: MUM1-ALB
Fusion gene ID: 56057
HgeneTgene
Gene symbol

MUM1

ALB

Gene ID

84939

213

Gene namePWWP domain containing 3A, DNA repair factoralbumin
SynonymsEXPAND1|HSPC211|MUM-1|MUM1HSA|PRO0883|PRO0903|PRO1341
Cytomap

19p13.3

4q13.3

Type of geneprotein-codingprotein-coding
DescriptionPWWP domain-containing DNA repair factor 3APWWP domain-containing protein MUM1melanoma associated antigen (mutated) 1melanoma ubiquitous mutated proteinmutated melanoma-associated antigen 1protein expandereserum albumin
Modification date2020031320200329
UniProtAcc.

P02768

Ensembl transtripts involved in fusion geneENST00000311401, ENST00000344663, 
ENST00000415183, ENST00000591806, 
ENST00000591453, 		ENST00000505649, 
ENST00000295897, ENST00000401494, 
ENST00000415165, ENST00000503124, 
ENST00000509063, 
Fusion gene scores* DoF score5 X 5 X 5=12549 X 62 X 5=15190
# samples 564
** MAII scorelog2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(64/15190*10)=-4.56890615450208
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MUM1 [Title/Abstract] AND ALB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMUM1(1360825)-ALB(74283802), # samples:1
Anticipated loss of major functional domain due to fusion event.MUM1-ALB seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
MUM1-ALB seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MUM1-ALB seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneALB

GO:0009267

cellular response to starvation

16245148

TgeneALB

GO:0043066

negative regulation of apoptotic process

16153637

TgeneALB

GO:0051659

maintenance of mitochondrion location

16153637


check buttonFusion gene breakpoints across MUM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ALB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-CC-5261-01AMUM1chr19

1360825

+ALBchr4

74283802

+


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Fusion Gene ORF analysis for MUM1-ALB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000311401ENST00000505649MUM1chr19

1360825

+ALBchr4

74283802

+
5CDS-3UTRENST00000344663ENST00000505649MUM1chr19

1360825

+ALBchr4

74283802

+
5CDS-3UTRENST00000415183ENST00000505649MUM1chr19

1360825

+ALBchr4

74283802

+
5CDS-3UTRENST00000591806ENST00000505649MUM1chr19

1360825

+ALBchr4

74283802

+
Frame-shiftENST00000311401ENST00000295897MUM1chr19

1360825

+ALBchr4

74283802

+
Frame-shiftENST00000311401ENST00000401494MUM1chr19

1360825

+ALBchr4

74283802

+
Frame-shiftENST00000311401ENST00000415165MUM1chr19

1360825

+ALBchr4

74283802

+
Frame-shiftENST00000311401ENST00000503124MUM1chr19

1360825

+ALBchr4

74283802

+
Frame-shiftENST00000311401ENST00000509063MUM1chr19

1360825

+ALBchr4

74283802

+
Frame-shiftENST00000344663ENST00000295897MUM1chr19

1360825

+ALBchr4

74283802

+
Frame-shiftENST00000344663ENST00000401494MUM1chr19

1360825

+ALBchr4

74283802

+
Frame-shiftENST00000344663ENST00000415165MUM1chr19

1360825

+ALBchr4

74283802

+
Frame-shiftENST00000344663ENST00000503124MUM1chr19

1360825

+ALBchr4

74283802

+
Frame-shiftENST00000344663ENST00000509063MUM1chr19

1360825

+ALBchr4

74283802

+
Frame-shiftENST00000415183ENST00000295897MUM1chr19

1360825

+ALBchr4

74283802

+
Frame-shiftENST00000415183ENST00000401494MUM1chr19

1360825

+ALBchr4

74283802

+
Frame-shiftENST00000415183ENST00000415165MUM1chr19

1360825

+ALBchr4

74283802

+
Frame-shiftENST00000415183ENST00000503124MUM1chr19

1360825

+ALBchr4

74283802

+
Frame-shiftENST00000415183ENST00000509063MUM1chr19

1360825

+ALBchr4

74283802

+
Frame-shiftENST00000591806ENST00000295897MUM1chr19

1360825

+ALBchr4

74283802

+
Frame-shiftENST00000591806ENST00000401494MUM1chr19

1360825

+ALBchr4

74283802

+
Frame-shiftENST00000591806ENST00000415165MUM1chr19

1360825

+ALBchr4

74283802

+
Frame-shiftENST00000591806ENST00000503124MUM1chr19

1360825

+ALBchr4

74283802

+
Frame-shiftENST00000591806ENST00000509063MUM1chr19

1360825

+ALBchr4

74283802

+
intron-3CDSENST00000591453ENST00000295897MUM1chr19

1360825

+ALBchr4

74283802

+
intron-3CDSENST00000591453ENST00000401494MUM1chr19

1360825

+ALBchr4

74283802

+
intron-3CDSENST00000591453ENST00000415165MUM1chr19

1360825

+ALBchr4

74283802

+
intron-3CDSENST00000591453ENST00000503124MUM1chr19

1360825

+ALBchr4

74283802

+
intron-3CDSENST00000591453ENST00000509063MUM1chr19

1360825

+ALBchr4

74283802

+
intron-3UTRENST00000591453ENST00000505649MUM1chr19

1360825

+ALBchr4

74283802

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MUM1-ALB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MUM1-ALB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:1360825/:74283802)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ALB

P02768

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (PubMed:19021548). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (PubMed:6234017). Does not prevent iron uptake by the bacterial siderophore aerobactin (PubMed:6234017). {ECO:0000250|UniProtKB:P02769, ECO:0000269|PubMed:19021548, ECO:0000269|PubMed:6234017, ECO:0000305|PubMed:1630489}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MUM1-ALB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MUM1-ALB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MUM1-ALB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MUM1-ALB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource