FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MVB12B-TG (FusionGDB2 ID:56092)

Fusion Gene Summary for MVB12B-TG

check button Fusion gene summary
Fusion gene informationFusion gene name: MVB12B-TG
Fusion gene ID: 56092
HgeneTgene
Gene symbol

MVB12B

TG

Gene ID

89853

7038

Gene namemultivesicular body subunit 12Bthyroglobulin
SynonymsC9orf28|FAM125BAITD3|TGN
Cytomap

9q33.3

8q24.22

Type of geneprotein-codingprotein-coding
Descriptionmultivesicular body subunit 12BESCRT-I complex subunit MVB12Bfamily with sequence similarity 125, member Bthyroglobulin
Modification date2020031320200313
UniProtAcc

Q9H7P6

TIAF1

Ensembl transtripts involved in fusion geneENST00000361171, ENST00000436593, 
ENST00000545391, ENST00000485886, 
ENST00000535766, 		ENST00000522523, 
ENST00000220616, ENST00000377869, 
ENST00000519543, ENST00000542445, 
Fusion gene scores* DoF score12 X 12 X 4=57627 X 26 X 8=5616
# samples 1329
** MAII scorelog2(13/576*10)=-2.14755718841386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(29/5616*10)=-4.27541813028963
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MVB12B [Title/Abstract] AND TG [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMVB12B(129102909)-TG(134107288), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MVB12B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EB-A24D-01AMVB12Bchr9

129102909

+TGchr8

134107288

+


Top

Fusion Gene ORF analysis for MVB12B-TG

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000361171ENST00000522523MVB12Bchr9

129102909

+TGchr8

134107288

+
5CDS-intronENST00000436593ENST00000522523MVB12Bchr9

129102909

+TGchr8

134107288

+
5CDS-intronENST00000545391ENST00000522523MVB12Bchr9

129102909

+TGchr8

134107288

+
In-frameENST00000361171ENST00000220616MVB12Bchr9

129102909

+TGchr8

134107288

+
In-frameENST00000361171ENST00000377869MVB12Bchr9

129102909

+TGchr8

134107288

+
In-frameENST00000361171ENST00000519543MVB12Bchr9

129102909

+TGchr8

134107288

+
In-frameENST00000361171ENST00000542445MVB12Bchr9

129102909

+TGchr8

134107288

+
In-frameENST00000436593ENST00000220616MVB12Bchr9

129102909

+TGchr8

134107288

+
In-frameENST00000436593ENST00000377869MVB12Bchr9

129102909

+TGchr8

134107288

+
In-frameENST00000436593ENST00000519543MVB12Bchr9

129102909

+TGchr8

134107288

+
In-frameENST00000436593ENST00000542445MVB12Bchr9

129102909

+TGchr8

134107288

+
In-frameENST00000545391ENST00000220616MVB12Bchr9

129102909

+TGchr8

134107288

+
In-frameENST00000545391ENST00000377869MVB12Bchr9

129102909

+TGchr8

134107288

+
In-frameENST00000545391ENST00000519543MVB12Bchr9

129102909

+TGchr8

134107288

+
In-frameENST00000545391ENST00000542445MVB12Bchr9

129102909

+TGchr8

134107288

+
intron-3CDSENST00000485886ENST00000220616MVB12Bchr9

129102909

+TGchr8

134107288

+
intron-3CDSENST00000485886ENST00000377869MVB12Bchr9

129102909

+TGchr8

134107288

+
intron-3CDSENST00000485886ENST00000519543MVB12Bchr9

129102909

+TGchr8

134107288

+
intron-3CDSENST00000485886ENST00000542445MVB12Bchr9

129102909

+TGchr8

134107288

+
intron-3CDSENST00000535766ENST00000220616MVB12Bchr9

129102909

+TGchr8

134107288

+
intron-3CDSENST00000535766ENST00000377869MVB12Bchr9

129102909

+TGchr8

134107288

+
intron-3CDSENST00000535766ENST00000519543MVB12Bchr9

129102909

+TGchr8

134107288

+
intron-3CDSENST00000535766ENST00000542445MVB12Bchr9

129102909

+TGchr8

134107288

+
intron-intronENST00000485886ENST00000522523MVB12Bchr9

129102909

+TGchr8

134107288

+
intron-intronENST00000535766ENST00000522523MVB12Bchr9

129102909

+TGchr8

134107288

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000545391MVB12Bchr9129102909+ENST00000377869TGchr8134107288+1458285421352436
ENST00000545391MVB12Bchr9129102909+ENST00000220616TGchr8134107288+1456285421352436
ENST00000545391MVB12Bchr9129102909+ENST00000542445TGchr8134107288+1386285421352436
ENST00000545391MVB12Bchr9129102909+ENST00000519543TGchr8134107288+1462285421352436
ENST00000361171MVB12Bchr9129102909+ENST00000377869TGchr8134107288+1458285421352436
ENST00000361171MVB12Bchr9129102909+ENST00000220616TGchr8134107288+1456285421352436
ENST00000361171MVB12Bchr9129102909+ENST00000542445TGchr8134107288+1386285421352436
ENST00000361171MVB12Bchr9129102909+ENST00000519543TGchr8134107288+1462285421352436
ENST00000436593MVB12Bchr9129102909+ENST00000377869TGchr8134107288+14572841251351408
ENST00000436593MVB12Bchr9129102909+ENST00000220616TGchr8134107288+14552841251351408
ENST00000436593MVB12Bchr9129102909+ENST00000542445TGchr8134107288+13852841251351408
ENST00000436593MVB12Bchr9129102909+ENST00000519543TGchr8134107288+14612841251351408

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000545391ENST00000377869MVB12Bchr9129102909+TGchr8134107288+0.0146232940.98537666
ENST00000545391ENST00000220616MVB12Bchr9129102909+TGchr8134107288+0.0145335650.9854665
ENST00000545391ENST00000542445MVB12Bchr9129102909+TGchr8134107288+0.0150718570.9849281
ENST00000545391ENST00000519543MVB12Bchr9129102909+TGchr8134107288+0.0142528090.98574716
ENST00000361171ENST00000377869MVB12Bchr9129102909+TGchr8134107288+0.0146232940.98537666
ENST00000361171ENST00000220616MVB12Bchr9129102909+TGchr8134107288+0.0145335650.9854665
ENST00000361171ENST00000542445MVB12Bchr9129102909+TGchr8134107288+0.0150718570.9849281
ENST00000361171ENST00000519543MVB12Bchr9129102909+TGchr8134107288+0.0142528090.98574716
ENST00000436593ENST00000377869MVB12Bchr9129102909+TGchr8134107288+0.0050232750.9949767
ENST00000436593ENST00000220616MVB12Bchr9129102909+TGchr8134107288+0.0049504420.99504954
ENST00000436593ENST00000542445MVB12Bchr9129102909+TGchr8134107288+0.0055000170.9944999
ENST00000436593ENST00000519543MVB12Bchr9129102909+TGchr8134107288+0.0051643120.99483573

Top

Fusion Genomic Features for MVB12B-TG


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for MVB12B-TG


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:129102909/chr8:134107288)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MVB12B

Q9H7P6

TG

TIAF1

FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies.115

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMVB12Bchr9:129102909chr8:134107288ENST00000361171+210254_30368320.0DomainUMA
HgeneMVB12Bchr9:129102909chr8:134107288ENST00000361171+21047_19368320.0DomainMABP
HgeneMVB12Bchr9:129102909chr8:134107288ENST00000545391+26254_30368222.0DomainUMA
HgeneMVB12Bchr9:129102909chr8:134107288ENST00000545391+2647_19368222.0DomainMABP
TgeneTGchr9:129102909chr8:134107288ENST0000022061640481074_114524132769.0DomainThyroglobulin type-1 9
TgeneTGchr9:129102909chr8:134107288ENST0000022061640481146_121024132769.0DomainThyroglobulin type-1 10
TgeneTGchr9:129102909chr8:134107288ENST0000022061640481511_156524132769.0DomainThyroglobulin type-1 11
TgeneTGchr9:129102909chr8:134107288ENST000002206164048161_29724132769.0DomainThyroglobulin type-1 3
TgeneTGchr9:129102909chr8:134107288ENST000002206164048298_35824132769.0DomainThyroglobulin type-1 4
TgeneTGchr9:129102909chr8:134107288ENST00000220616404831_9224132769.0DomainThyroglobulin type-1 1
TgeneTGchr9:129102909chr8:134107288ENST000002206164048605_65824132769.0DomainThyroglobulin type-1 5
TgeneTGchr9:129102909chr8:134107288ENST000002206164048659_72624132769.0DomainThyroglobulin type-1 6
TgeneTGchr9:129102909chr8:134107288ENST000002206164048727_92124132769.0DomainThyroglobulin type-1 7
TgeneTGchr9:129102909chr8:134107288ENST000002206164048922_107324132769.0DomainThyroglobulin type-1 8
TgeneTGchr9:129102909chr8:134107288ENST00000220616404893_16024132769.0DomainThyroglobulin type-1 2
TgeneTGchr9:129102909chr8:134107288ENST0000037786939471074_114523562712.0DomainThyroglobulin type-1 9
TgeneTGchr9:129102909chr8:134107288ENST0000037786939471146_121023562712.0DomainThyroglobulin type-1 10
TgeneTGchr9:129102909chr8:134107288ENST0000037786939471511_156523562712.0DomainThyroglobulin type-1 11
TgeneTGchr9:129102909chr8:134107288ENST000003778693947161_29723562712.0DomainThyroglobulin type-1 3
TgeneTGchr9:129102909chr8:134107288ENST000003778693947298_35823562712.0DomainThyroglobulin type-1 4
TgeneTGchr9:129102909chr8:134107288ENST00000377869394731_9223562712.0DomainThyroglobulin type-1 1
TgeneTGchr9:129102909chr8:134107288ENST000003778693947605_65823562712.0DomainThyroglobulin type-1 5
TgeneTGchr9:129102909chr8:134107288ENST000003778693947659_72623562712.0DomainThyroglobulin type-1 6
TgeneTGchr9:129102909chr8:134107288ENST000003778693947727_92123562712.0DomainThyroglobulin type-1 7
TgeneTGchr9:129102909chr8:134107288ENST000003778693947922_107323562712.0DomainThyroglobulin type-1 8
TgeneTGchr9:129102909chr8:134107288ENST00000377869394793_16023562712.0DomainThyroglobulin type-1 2
TgeneTGchr9:129102909chr8:134107288ENST0000022061640482188_276824132769.0RegionCholinesterase-like (ChEL)
TgeneTGchr9:129102909chr8:134107288ENST0000037786939472188_276823562712.0RegionCholinesterase-like (ChEL)
TgeneTGchr9:129102909chr8:134107288ENST0000022061640481456_146924132769.0RepeatType II
TgeneTGchr9:129102909chr8:134107288ENST0000022061640481470_148624132769.0RepeatType II
TgeneTGchr9:129102909chr8:134107288ENST0000022061640481487_150324132769.0RepeatType II
TgeneTGchr9:129102909chr8:134107288ENST0000022061640481603_172324132769.0RepeatType IIIA
TgeneTGchr9:129102909chr8:134107288ENST0000022061640481724_189224132769.0RepeatType IIIB
TgeneTGchr9:129102909chr8:134107288ENST0000022061640481893_199524132769.0RepeatType IIIA
TgeneTGchr9:129102909chr8:134107288ENST0000022061640481996_212924132769.0RepeatType IIIB
TgeneTGchr9:129102909chr8:134107288ENST0000022061640482130_218724132769.0RepeatType IIIA
TgeneTGchr9:129102909chr8:134107288ENST0000037786939471456_146923562712.0RepeatType II
TgeneTGchr9:129102909chr8:134107288ENST0000037786939471470_148623562712.0RepeatType II
TgeneTGchr9:129102909chr8:134107288ENST0000037786939471487_150323562712.0RepeatType II
TgeneTGchr9:129102909chr8:134107288ENST0000037786939471603_172323562712.0RepeatType IIIA
TgeneTGchr9:129102909chr8:134107288ENST0000037786939471724_189223562712.0RepeatType IIIB
TgeneTGchr9:129102909chr8:134107288ENST0000037786939471893_199523562712.0RepeatType IIIA
TgeneTGchr9:129102909chr8:134107288ENST0000037786939471996_212923562712.0RepeatType IIIB
TgeneTGchr9:129102909chr8:134107288ENST0000037786939472130_218723562712.0RepeatType IIIA


Top

Fusion Gene Sequence for MVB12B-TG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>56092_56092_1_MVB12B-TG_MVB12B_chr9_129102909_ENST00000361171_TG_chr8_134107288_ENST00000220616_length(transcript)=1456nt_BP=285nt
CGGTGAGGCTCGCGCTCGAGCTGCGGCGCCGGCTCCTGCCGCCTGGGCCCCGGGCCCGGCCCCTCCCGCGCCGCCCGGGCGATGAGAAGC
TGCTTCTGCGTGAGACGGAGCCGGGACCCGCCGCCGCCGCAGCCACCGCCGCCGCCGCCCCAGCGGGGAACAGACCAGTCCACCATGCCT
GAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCG
ACAGGCTATGACGTAGGAGGCTCCGCACTCTCCCCGGCCGCCGTCATCAGCCATGAGAGGGCTCAGCAGCAGGCAATTGCTTTGGCAAAG
GAGGTCAGTTGCCCCATGTCATCCAGCCAAGAAGTGGTGTCCTGCCTCCGCCAGAAGCCTGCCAATGTCCTCAATGATGCCCAGACCAAG
CTCCTGGCCGTGAGTGGCCCTTTCCACTACTGGGGTCCTGTGATCGATGGCCACTTCCTCCGTGAGCCTCCAGCCAGAGCACTGAAGAGG
TCTTTATGGGTAGAGGTCGATCTGCTCATTGGGAGTTCTCAGGACGACGGGCTCATCAACAGAGCAAAGGCTGTGAAGCAATTTGAGGAA
AGTCGAGGCCGGACCAGTAGCAAAACAGCCTTTTACCAGGCACTGCAGAATTCTCTGGGTGGCGAGGACTCAGATGCCCGCGTCGAGGCT
GCTGCTACATGGTATTACTCTCTGGAGCACTCCACGGATGACTATGCCTCCTTCTCCCGGGCTCTGGAGAATGCCACCCGGGACTACTTT
ATCATCTGCCCTATAATCGACATGGCCAGTGCCTGGGCAAAGAGGGCCCGAGGAAACGTCTTCATGTACCATGCTCCTGAAAACTACGGC
CATGGCAGCCTGGAGCTGCTGGCGGATGTTCAGTTTGCCTTGGGGCTTCCCTTCTACCCAGCCTACGAGGGGCAGTTTTCTCTGGAGGAG
AAGAGCCTGTCGCTGAAAATCATGCAGTACTTTTCCCACTTCATCAGATCAGGAAATCCCAACTACCCTTATGAGTTCTCACGGAAAGTA
CCCACATTTGCAACCCCCTGGCCTGACTTTGTACCCCGTGCTGGTGGAGAGAACTACAAGGAGTTCAGTGAGCTGCTCCCCAATCGACAG
GGCCTGAAGAAAGCCGACTGCTCCTTCTGGTCCAAGTACATCTCGTCTCTGAAGACATCTGCAGATGGAGCCAAGGGCGGGCAGTCAGCA
GAGAGTGAAGAGGAGGAGTTGACGGCTGGATCTGGGCTAAGAGAAGATCTCCTAAGCCTCCAGGAACCAGGCTCTAAGACCTACAGCAAG
TGACCAGCCCTTGAGCTCCCCAAAAACCTCACCCGAGGCTGCCCACTATGGTCATCTTTTTCTCTAAAATAGCCACTTACCTTCAATAAA

>56092_56092_1_MVB12B-TG_MVB12B_chr9_129102909_ENST00000361171_TG_chr8_134107288_ENST00000220616_length(amino acids)=436AA_BP=81
MGPGPGPSRAARAMRSCFCVRRSRDPPPPQPPPPPPQRGTDQSTMPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVGGSALSPAA
VISHERAQQQAIALAKEVSCPMSSSQEVVSCLRQKPANVLNDAQTKLLAVSGPFHYWGPVIDGHFLREPPARALKRSLWVEVDLLIGSSQ
DDGLINRAKAVKQFEESRGRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRALENATRDYFIICPIIDMASAWAK
RARGNVFMYHAPENYGHGSLELLADVQFALGLPFYPAYEGQFSLEEKSLSLKIMQYFSHFIRSGNPNYPYEFSRKVPTFATPWPDFVPRA

--------------------------------------------------------------
>56092_56092_2_MVB12B-TG_MVB12B_chr9_129102909_ENST00000361171_TG_chr8_134107288_ENST00000377869_length(transcript)=1458nt_BP=285nt
CGGTGAGGCTCGCGCTCGAGCTGCGGCGCCGGCTCCTGCCGCCTGGGCCCCGGGCCCGGCCCCTCCCGCGCCGCCCGGGCGATGAGAAGC
TGCTTCTGCGTGAGACGGAGCCGGGACCCGCCGCCGCCGCAGCCACCGCCGCCGCCGCCCCAGCGGGGAACAGACCAGTCCACCATGCCT
GAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCG
ACAGGCTATGACGTAGGAGGCTCCGCACTCTCCCCGGCCGCCGTCATCAGCCATGAGAGGGCTCAGCAGCAGGCAATTGCTTTGGCAAAG
GAGGTCAGTTGCCCCATGTCATCCAGCCAAGAAGTGGTGTCCTGCCTCCGCCAGAAGCCTGCCAATGTCCTCAATGATGCCCAGACCAAG
CTCCTGGCCGTGAGTGGCCCTTTCCACTACTGGGGTCCTGTGATCGATGGCCACTTCCTCCGTGAGCCTCCAGCCAGAGCACTGAAGAGG
TCTTTATGGGTAGAGGTCGATCTGCTCATTGGGAGTTCTCAGGACGACGGGCTCATCAACAGAGCAAAGGCTGTGAAGCAATTTGAGGAA
AGTCGAGGCCGGACCAGTAGCAAAACAGCCTTTTACCAGGCACTGCAGAATTCTCTGGGTGGCGAGGACTCAGATGCCCGCGTCGAGGCT
GCTGCTACATGGTATTACTCTCTGGAGCACTCCACGGATGACTATGCCTCCTTCTCCCGGGCTCTGGAGAATGCCACCCGGGACTACTTT
ATCATCTGCCCTATAATCGACATGGCCAGTGCCTGGGCAAAGAGGGCCCGAGGAAACGTCTTCATGTACCATGCTCCTGAAAACTACGGC
CATGGCAGCCTGGAGCTGCTGGCGGATGTTCAGTTTGCCTTGGGGCTTCCCTTCTACCCAGCCTACGAGGGGCAGTTTTCTCTGGAGGAG
AAGAGCCTGTCGCTGAAAATCATGCAGTACTTTTCCCACTTCATCAGATCAGGAAATCCCAACTACCCTTATGAGTTCTCACGGAAAGTA
CCCACATTTGCAACCCCCTGGCCTGACTTTGTACCCCGTGCTGGTGGAGAGAACTACAAGGAGTTCAGTGAGCTGCTCCCCAATCGACAG
GGCCTGAAGAAAGCCGACTGCTCCTTCTGGTCCAAGTACATCTCGTCTCTGAAGACATCTGCAGATGGAGCCAAGGGCGGGCAGTCAGCA
GAGAGTGAAGAGGAGGAGTTGACGGCTGGATCTGGGCTAAGAGAAGATCTCCTAAGCCTCCAGGAACCAGGCTCTAAGACCTACAGCAAG
TGACCAGCCCTTGAGCTCCCCAAAAACCTCACCCGAGGCTGCCCACTATGGTCATCTTTTTCTCTAAAATAGCCACTTACCTTCAATAAA

>56092_56092_2_MVB12B-TG_MVB12B_chr9_129102909_ENST00000361171_TG_chr8_134107288_ENST00000377869_length(amino acids)=436AA_BP=81
MGPGPGPSRAARAMRSCFCVRRSRDPPPPQPPPPPPQRGTDQSTMPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVGGSALSPAA
VISHERAQQQAIALAKEVSCPMSSSQEVVSCLRQKPANVLNDAQTKLLAVSGPFHYWGPVIDGHFLREPPARALKRSLWVEVDLLIGSSQ
DDGLINRAKAVKQFEESRGRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRALENATRDYFIICPIIDMASAWAK
RARGNVFMYHAPENYGHGSLELLADVQFALGLPFYPAYEGQFSLEEKSLSLKIMQYFSHFIRSGNPNYPYEFSRKVPTFATPWPDFVPRA

--------------------------------------------------------------
>56092_56092_3_MVB12B-TG_MVB12B_chr9_129102909_ENST00000361171_TG_chr8_134107288_ENST00000519543_length(transcript)=1462nt_BP=285nt
CGGTGAGGCTCGCGCTCGAGCTGCGGCGCCGGCTCCTGCCGCCTGGGCCCCGGGCCCGGCCCCTCCCGCGCCGCCCGGGCGATGAGAAGC
TGCTTCTGCGTGAGACGGAGCCGGGACCCGCCGCCGCCGCAGCCACCGCCGCCGCCGCCCCAGCGGGGAACAGACCAGTCCACCATGCCT
GAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCG
ACAGGCTATGACGTAGGAGGCTCCGCACTCTCCCCGGCCGCCGTCATCAGCCATGAGAGGGCTCAGCAGCAGGCAATTGCTTTGGCAAAG
GAGGTCAGTTGCCCCATGTCATCCAGCCAAGAAGTGGTGTCCTGCCTCCGCCAGAAGCCTGCCAATGTCCTCAATGATGCCCAGACCAAG
CTCCTGGCCGTGAGTGGCCCTTTCCACTACTGGGGTCCTGTGATCGATGGCCACTTCCTCCGTGAGCCTCCAGCCAGAGCACTGAAGAGG
TCTTTATGGGTAGAGGTCGATCTGCTCATTGGGAGTTCTCAGGACGACGGGCTCATCAACAGAGCAAAGGCTGTGAAGCAATTTGAGGAA
AGTCGAGGCCGGACCAGTAGCAAAACAGCCTTTTACCAGGCACTGCAGAATTCTCTGGGTGGCGAGGACTCAGATGCCCGCGTCGAGGCT
GCTGCTACATGGTATTACTCTCTGGAGCACTCCACGGATGACTATGCCTCCTTCTCCCGGGCTCTGGAGAATGCCACCCGGGACTACTTT
ATCATCTGCCCTATAATCGACATGGCCAGTGCCTGGGCAAAGAGGGCCCGAGGAAACGTCTTCATGTACCATGCTCCTGAAAACTACGGC
CATGGCAGCCTGGAGCTGCTGGCGGATGTTCAGTTTGCCTTGGGGCTTCCCTTCTACCCAGCCTACGAGGGGCAGTTTTCTCTGGAGGAG
AAGAGCCTGTCGCTGAAAATCATGCAGTACTTTTCCCACTTCATCAGATCAGGAAATCCCAACTACCCTTATGAGTTCTCACGGAAAGTA
CCCACATTTGCAACCCCCTGGCCTGACTTTGTACCCCGTGCTGGTGGAGAGAACTACAAGGAGTTCAGTGAGCTGCTCCCCAATCGACAG
GGCCTGAAGAAAGCCGACTGCTCCTTCTGGTCCAAGTACATCTCGTCTCTGAAGACATCTGCAGATGGAGCCAAGGGCGGGCAGTCAGCA
GAGAGTGAAGAGGAGGAGTTGACGGCTGGATCTGGGCTAAGAGAAGATCTCCTAAGCCTCCAGGAACCAGGCTCTAAGACCTACAGCAAG
TGACCAGCCCTTGAGCTCCCCAAAAACCTCACCCGAGGCTGCCCACTATGGTCATCTTTTTCTCTAAAATAGCCACTTACCTTCAATAAA

>56092_56092_3_MVB12B-TG_MVB12B_chr9_129102909_ENST00000361171_TG_chr8_134107288_ENST00000519543_length(amino acids)=436AA_BP=81
MGPGPGPSRAARAMRSCFCVRRSRDPPPPQPPPPPPQRGTDQSTMPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVGGSALSPAA
VISHERAQQQAIALAKEVSCPMSSSQEVVSCLRQKPANVLNDAQTKLLAVSGPFHYWGPVIDGHFLREPPARALKRSLWVEVDLLIGSSQ
DDGLINRAKAVKQFEESRGRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRALENATRDYFIICPIIDMASAWAK
RARGNVFMYHAPENYGHGSLELLADVQFALGLPFYPAYEGQFSLEEKSLSLKIMQYFSHFIRSGNPNYPYEFSRKVPTFATPWPDFVPRA

--------------------------------------------------------------
>56092_56092_4_MVB12B-TG_MVB12B_chr9_129102909_ENST00000361171_TG_chr8_134107288_ENST00000542445_length(transcript)=1386nt_BP=285nt
CGGTGAGGCTCGCGCTCGAGCTGCGGCGCCGGCTCCTGCCGCCTGGGCCCCGGGCCCGGCCCCTCCCGCGCCGCCCGGGCGATGAGAAGC
TGCTTCTGCGTGAGACGGAGCCGGGACCCGCCGCCGCCGCAGCCACCGCCGCCGCCGCCCCAGCGGGGAACAGACCAGTCCACCATGCCT
GAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCG
ACAGGCTATGACGTAGGAGGCTCCGCACTCTCCCCGGCCGCCGTCATCAGCCATGAGAGGGCTCAGCAGCAGGCAATTGCTTTGGCAAAG
GAGGTCAGTTGCCCCATGTCATCCAGCCAAGAAGTGGTGTCCTGCCTCCGCCAGAAGCCTGCCAATGTCCTCAATGATGCCCAGACCAAG
CTCCTGGCCGTGAGTGGCCCTTTCCACTACTGGGGTCCTGTGATCGATGGCCACTTCCTCCGTGAGCCTCCAGCCAGAGCACTGAAGAGG
TCTTTATGGGTAGAGGTCGATCTGCTCATTGGGAGTTCTCAGGACGACGGGCTCATCAACAGAGCAAAGGCTGTGAAGCAATTTGAGGAA
AGTCGAGGCCGGACCAGTAGCAAAACAGCCTTTTACCAGGCACTGCAGAATTCTCTGGGTGGCGAGGACTCAGATGCCCGCGTCGAGGCT
GCTGCTACATGGTATTACTCTCTGGAGCACTCCACGGATGACTATGCCTCCTTCTCCCGGGCTCTGGAGAATGCCACCCGGGACTACTTT
ATCATCTGCCCTATAATCGACATGGCCAGTGCCTGGGCAAAGAGGGCCCGAGGAAACGTCTTCATGTACCATGCTCCTGAAAACTACGGC
CATGGCAGCCTGGAGCTGCTGGCGGATGTTCAGTTTGCCTTGGGGCTTCCCTTCTACCCAGCCTACGAGGGGCAGTTTTCTCTGGAGGAG
AAGAGCCTGTCGCTGAAAATCATGCAGTACTTTTCCCACTTCATCAGATCAGGAAATCCCAACTACCCTTATGAGTTCTCACGGAAAGTA
CCCACATTTGCAACCCCCTGGCCTGACTTTGTACCCCGTGCTGGTGGAGAGAACTACAAGGAGTTCAGTGAGCTGCTCCCCAATCGACAG
GGCCTGAAGAAAGCCGACTGCTCCTTCTGGTCCAAGTACATCTCGTCTCTGAAGACATCTGCAGATGGAGCCAAGGGCGGGCAGTCAGCA
GAGAGTGAAGAGGAGGAGTTGACGGCTGGATCTGGGCTAAGAGAAGATCTCCTAAGCCTCCAGGAACCAGGCTCTAAGACCTACAGCAAG

>56092_56092_4_MVB12B-TG_MVB12B_chr9_129102909_ENST00000361171_TG_chr8_134107288_ENST00000542445_length(amino acids)=436AA_BP=81
MGPGPGPSRAARAMRSCFCVRRSRDPPPPQPPPPPPQRGTDQSTMPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVGGSALSPAA
VISHERAQQQAIALAKEVSCPMSSSQEVVSCLRQKPANVLNDAQTKLLAVSGPFHYWGPVIDGHFLREPPARALKRSLWVEVDLLIGSSQ
DDGLINRAKAVKQFEESRGRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRALENATRDYFIICPIIDMASAWAK
RARGNVFMYHAPENYGHGSLELLADVQFALGLPFYPAYEGQFSLEEKSLSLKIMQYFSHFIRSGNPNYPYEFSRKVPTFATPWPDFVPRA

--------------------------------------------------------------
>56092_56092_5_MVB12B-TG_MVB12B_chr9_129102909_ENST00000436593_TG_chr8_134107288_ENST00000220616_length(transcript)=1455nt_BP=284nt
AATCTGTCCAAAGTTCAGAAGGTGTCAGGATGCTATCCTGAGGCTCCACAGTGACAGCCTCTCAGTCTGTGCACTGTCCCCCACGGGTGG
CCCCAAAGCCAGCTGCCCATTTAACTGGGCACAGCATGGACACTGGCCTCAGCTCTCAGCCTTCTGAGGAGGACCAGTCCACCATGCCTG
AAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCGA
CAGGCTATGACGTAGGAGGCTCCGCACTCTCCCCGGCCGCCGTCATCAGCCATGAGAGGGCTCAGCAGCAGGCAATTGCTTTGGCAAAGG
AGGTCAGTTGCCCCATGTCATCCAGCCAAGAAGTGGTGTCCTGCCTCCGCCAGAAGCCTGCCAATGTCCTCAATGATGCCCAGACCAAGC
TCCTGGCCGTGAGTGGCCCTTTCCACTACTGGGGTCCTGTGATCGATGGCCACTTCCTCCGTGAGCCTCCAGCCAGAGCACTGAAGAGGT
CTTTATGGGTAGAGGTCGATCTGCTCATTGGGAGTTCTCAGGACGACGGGCTCATCAACAGAGCAAAGGCTGTGAAGCAATTTGAGGAAA
GTCGAGGCCGGACCAGTAGCAAAACAGCCTTTTACCAGGCACTGCAGAATTCTCTGGGTGGCGAGGACTCAGATGCCCGCGTCGAGGCTG
CTGCTACATGGTATTACTCTCTGGAGCACTCCACGGATGACTATGCCTCCTTCTCCCGGGCTCTGGAGAATGCCACCCGGGACTACTTTA
TCATCTGCCCTATAATCGACATGGCCAGTGCCTGGGCAAAGAGGGCCCGAGGAAACGTCTTCATGTACCATGCTCCTGAAAACTACGGCC
ATGGCAGCCTGGAGCTGCTGGCGGATGTTCAGTTTGCCTTGGGGCTTCCCTTCTACCCAGCCTACGAGGGGCAGTTTTCTCTGGAGGAGA
AGAGCCTGTCGCTGAAAATCATGCAGTACTTTTCCCACTTCATCAGATCAGGAAATCCCAACTACCCTTATGAGTTCTCACGGAAAGTAC
CCACATTTGCAACCCCCTGGCCTGACTTTGTACCCCGTGCTGGTGGAGAGAACTACAAGGAGTTCAGTGAGCTGCTCCCCAATCGACAGG
GCCTGAAGAAAGCCGACTGCTCCTTCTGGTCCAAGTACATCTCGTCTCTGAAGACATCTGCAGATGGAGCCAAGGGCGGGCAGTCAGCAG
AGAGTGAAGAGGAGGAGTTGACGGCTGGATCTGGGCTAAGAGAAGATCTCCTAAGCCTCCAGGAACCAGGCTCTAAGACCTACAGCAAGT
GACCAGCCCTTGAGCTCCCCAAAAACCTCACCCGAGGCTGCCCACTATGGTCATCTTTTTCTCTAAAATAGCCACTTACCTTCAATAAAG

>56092_56092_5_MVB12B-TG_MVB12B_chr9_129102909_ENST00000436593_TG_chr8_134107288_ENST00000220616_length(amino acids)=408AA_BP=53
MDTGLSSQPSEEDQSTMPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVGGSALSPAAVISHERAQQQAIALAKEVSCPMSSSQEV
VSCLRQKPANVLNDAQTKLLAVSGPFHYWGPVIDGHFLREPPARALKRSLWVEVDLLIGSSQDDGLINRAKAVKQFEESRGRTSSKTAFY
QALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRALENATRDYFIICPIIDMASAWAKRARGNVFMYHAPENYGHGSLELLADVQF
ALGLPFYPAYEGQFSLEEKSLSLKIMQYFSHFIRSGNPNYPYEFSRKVPTFATPWPDFVPRAGGENYKEFSELLPNRQGLKKADCSFWSK

--------------------------------------------------------------
>56092_56092_6_MVB12B-TG_MVB12B_chr9_129102909_ENST00000436593_TG_chr8_134107288_ENST00000377869_length(transcript)=1457nt_BP=284nt
AATCTGTCCAAAGTTCAGAAGGTGTCAGGATGCTATCCTGAGGCTCCACAGTGACAGCCTCTCAGTCTGTGCACTGTCCCCCACGGGTGG
CCCCAAAGCCAGCTGCCCATTTAACTGGGCACAGCATGGACACTGGCCTCAGCTCTCAGCCTTCTGAGGAGGACCAGTCCACCATGCCTG
AAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCGA
CAGGCTATGACGTAGGAGGCTCCGCACTCTCCCCGGCCGCCGTCATCAGCCATGAGAGGGCTCAGCAGCAGGCAATTGCTTTGGCAAAGG
AGGTCAGTTGCCCCATGTCATCCAGCCAAGAAGTGGTGTCCTGCCTCCGCCAGAAGCCTGCCAATGTCCTCAATGATGCCCAGACCAAGC
TCCTGGCCGTGAGTGGCCCTTTCCACTACTGGGGTCCTGTGATCGATGGCCACTTCCTCCGTGAGCCTCCAGCCAGAGCACTGAAGAGGT
CTTTATGGGTAGAGGTCGATCTGCTCATTGGGAGTTCTCAGGACGACGGGCTCATCAACAGAGCAAAGGCTGTGAAGCAATTTGAGGAAA
GTCGAGGCCGGACCAGTAGCAAAACAGCCTTTTACCAGGCACTGCAGAATTCTCTGGGTGGCGAGGACTCAGATGCCCGCGTCGAGGCTG
CTGCTACATGGTATTACTCTCTGGAGCACTCCACGGATGACTATGCCTCCTTCTCCCGGGCTCTGGAGAATGCCACCCGGGACTACTTTA
TCATCTGCCCTATAATCGACATGGCCAGTGCCTGGGCAAAGAGGGCCCGAGGAAACGTCTTCATGTACCATGCTCCTGAAAACTACGGCC
ATGGCAGCCTGGAGCTGCTGGCGGATGTTCAGTTTGCCTTGGGGCTTCCCTTCTACCCAGCCTACGAGGGGCAGTTTTCTCTGGAGGAGA
AGAGCCTGTCGCTGAAAATCATGCAGTACTTTTCCCACTTCATCAGATCAGGAAATCCCAACTACCCTTATGAGTTCTCACGGAAAGTAC
CCACATTTGCAACCCCCTGGCCTGACTTTGTACCCCGTGCTGGTGGAGAGAACTACAAGGAGTTCAGTGAGCTGCTCCCCAATCGACAGG
GCCTGAAGAAAGCCGACTGCTCCTTCTGGTCCAAGTACATCTCGTCTCTGAAGACATCTGCAGATGGAGCCAAGGGCGGGCAGTCAGCAG
AGAGTGAAGAGGAGGAGTTGACGGCTGGATCTGGGCTAAGAGAAGATCTCCTAAGCCTCCAGGAACCAGGCTCTAAGACCTACAGCAAGT
GACCAGCCCTTGAGCTCCCCAAAAACCTCACCCGAGGCTGCCCACTATGGTCATCTTTTTCTCTAAAATAGCCACTTACCTTCAATAAAG

>56092_56092_6_MVB12B-TG_MVB12B_chr9_129102909_ENST00000436593_TG_chr8_134107288_ENST00000377869_length(amino acids)=408AA_BP=53
MDTGLSSQPSEEDQSTMPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVGGSALSPAAVISHERAQQQAIALAKEVSCPMSSSQEV
VSCLRQKPANVLNDAQTKLLAVSGPFHYWGPVIDGHFLREPPARALKRSLWVEVDLLIGSSQDDGLINRAKAVKQFEESRGRTSSKTAFY
QALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRALENATRDYFIICPIIDMASAWAKRARGNVFMYHAPENYGHGSLELLADVQF
ALGLPFYPAYEGQFSLEEKSLSLKIMQYFSHFIRSGNPNYPYEFSRKVPTFATPWPDFVPRAGGENYKEFSELLPNRQGLKKADCSFWSK

--------------------------------------------------------------
>56092_56092_7_MVB12B-TG_MVB12B_chr9_129102909_ENST00000436593_TG_chr8_134107288_ENST00000519543_length(transcript)=1461nt_BP=284nt
AATCTGTCCAAAGTTCAGAAGGTGTCAGGATGCTATCCTGAGGCTCCACAGTGACAGCCTCTCAGTCTGTGCACTGTCCCCCACGGGTGG
CCCCAAAGCCAGCTGCCCATTTAACTGGGCACAGCATGGACACTGGCCTCAGCTCTCAGCCTTCTGAGGAGGACCAGTCCACCATGCCTG
AAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCGA
CAGGCTATGACGTAGGAGGCTCCGCACTCTCCCCGGCCGCCGTCATCAGCCATGAGAGGGCTCAGCAGCAGGCAATTGCTTTGGCAAAGG
AGGTCAGTTGCCCCATGTCATCCAGCCAAGAAGTGGTGTCCTGCCTCCGCCAGAAGCCTGCCAATGTCCTCAATGATGCCCAGACCAAGC
TCCTGGCCGTGAGTGGCCCTTTCCACTACTGGGGTCCTGTGATCGATGGCCACTTCCTCCGTGAGCCTCCAGCCAGAGCACTGAAGAGGT
CTTTATGGGTAGAGGTCGATCTGCTCATTGGGAGTTCTCAGGACGACGGGCTCATCAACAGAGCAAAGGCTGTGAAGCAATTTGAGGAAA
GTCGAGGCCGGACCAGTAGCAAAACAGCCTTTTACCAGGCACTGCAGAATTCTCTGGGTGGCGAGGACTCAGATGCCCGCGTCGAGGCTG
CTGCTACATGGTATTACTCTCTGGAGCACTCCACGGATGACTATGCCTCCTTCTCCCGGGCTCTGGAGAATGCCACCCGGGACTACTTTA
TCATCTGCCCTATAATCGACATGGCCAGTGCCTGGGCAAAGAGGGCCCGAGGAAACGTCTTCATGTACCATGCTCCTGAAAACTACGGCC
ATGGCAGCCTGGAGCTGCTGGCGGATGTTCAGTTTGCCTTGGGGCTTCCCTTCTACCCAGCCTACGAGGGGCAGTTTTCTCTGGAGGAGA
AGAGCCTGTCGCTGAAAATCATGCAGTACTTTTCCCACTTCATCAGATCAGGAAATCCCAACTACCCTTATGAGTTCTCACGGAAAGTAC
CCACATTTGCAACCCCCTGGCCTGACTTTGTACCCCGTGCTGGTGGAGAGAACTACAAGGAGTTCAGTGAGCTGCTCCCCAATCGACAGG
GCCTGAAGAAAGCCGACTGCTCCTTCTGGTCCAAGTACATCTCGTCTCTGAAGACATCTGCAGATGGAGCCAAGGGCGGGCAGTCAGCAG
AGAGTGAAGAGGAGGAGTTGACGGCTGGATCTGGGCTAAGAGAAGATCTCCTAAGCCTCCAGGAACCAGGCTCTAAGACCTACAGCAAGT
GACCAGCCCTTGAGCTCCCCAAAAACCTCACCCGAGGCTGCCCACTATGGTCATCTTTTTCTCTAAAATAGCCACTTACCTTCAATAAAG

>56092_56092_7_MVB12B-TG_MVB12B_chr9_129102909_ENST00000436593_TG_chr8_134107288_ENST00000519543_length(amino acids)=408AA_BP=53
MDTGLSSQPSEEDQSTMPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVGGSALSPAAVISHERAQQQAIALAKEVSCPMSSSQEV
VSCLRQKPANVLNDAQTKLLAVSGPFHYWGPVIDGHFLREPPARALKRSLWVEVDLLIGSSQDDGLINRAKAVKQFEESRGRTSSKTAFY
QALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRALENATRDYFIICPIIDMASAWAKRARGNVFMYHAPENYGHGSLELLADVQF
ALGLPFYPAYEGQFSLEEKSLSLKIMQYFSHFIRSGNPNYPYEFSRKVPTFATPWPDFVPRAGGENYKEFSELLPNRQGLKKADCSFWSK

--------------------------------------------------------------
>56092_56092_8_MVB12B-TG_MVB12B_chr9_129102909_ENST00000436593_TG_chr8_134107288_ENST00000542445_length(transcript)=1385nt_BP=284nt
AATCTGTCCAAAGTTCAGAAGGTGTCAGGATGCTATCCTGAGGCTCCACAGTGACAGCCTCTCAGTCTGTGCACTGTCCCCCACGGGTGG
CCCCAAAGCCAGCTGCCCATTTAACTGGGCACAGCATGGACACTGGCCTCAGCTCTCAGCCTTCTGAGGAGGACCAGTCCACCATGCCTG
AAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCGA
CAGGCTATGACGTAGGAGGCTCCGCACTCTCCCCGGCCGCCGTCATCAGCCATGAGAGGGCTCAGCAGCAGGCAATTGCTTTGGCAAAGG
AGGTCAGTTGCCCCATGTCATCCAGCCAAGAAGTGGTGTCCTGCCTCCGCCAGAAGCCTGCCAATGTCCTCAATGATGCCCAGACCAAGC
TCCTGGCCGTGAGTGGCCCTTTCCACTACTGGGGTCCTGTGATCGATGGCCACTTCCTCCGTGAGCCTCCAGCCAGAGCACTGAAGAGGT
CTTTATGGGTAGAGGTCGATCTGCTCATTGGGAGTTCTCAGGACGACGGGCTCATCAACAGAGCAAAGGCTGTGAAGCAATTTGAGGAAA
GTCGAGGCCGGACCAGTAGCAAAACAGCCTTTTACCAGGCACTGCAGAATTCTCTGGGTGGCGAGGACTCAGATGCCCGCGTCGAGGCTG
CTGCTACATGGTATTACTCTCTGGAGCACTCCACGGATGACTATGCCTCCTTCTCCCGGGCTCTGGAGAATGCCACCCGGGACTACTTTA
TCATCTGCCCTATAATCGACATGGCCAGTGCCTGGGCAAAGAGGGCCCGAGGAAACGTCTTCATGTACCATGCTCCTGAAAACTACGGCC
ATGGCAGCCTGGAGCTGCTGGCGGATGTTCAGTTTGCCTTGGGGCTTCCCTTCTACCCAGCCTACGAGGGGCAGTTTTCTCTGGAGGAGA
AGAGCCTGTCGCTGAAAATCATGCAGTACTTTTCCCACTTCATCAGATCAGGAAATCCCAACTACCCTTATGAGTTCTCACGGAAAGTAC
CCACATTTGCAACCCCCTGGCCTGACTTTGTACCCCGTGCTGGTGGAGAGAACTACAAGGAGTTCAGTGAGCTGCTCCCCAATCGACAGG
GCCTGAAGAAAGCCGACTGCTCCTTCTGGTCCAAGTACATCTCGTCTCTGAAGACATCTGCAGATGGAGCCAAGGGCGGGCAGTCAGCAG
AGAGTGAAGAGGAGGAGTTGACGGCTGGATCTGGGCTAAGAGAAGATCTCCTAAGCCTCCAGGAACCAGGCTCTAAGACCTACAGCAAGT

>56092_56092_8_MVB12B-TG_MVB12B_chr9_129102909_ENST00000436593_TG_chr8_134107288_ENST00000542445_length(amino acids)=408AA_BP=53
MDTGLSSQPSEEDQSTMPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVGGSALSPAAVISHERAQQQAIALAKEVSCPMSSSQEV
VSCLRQKPANVLNDAQTKLLAVSGPFHYWGPVIDGHFLREPPARALKRSLWVEVDLLIGSSQDDGLINRAKAVKQFEESRGRTSSKTAFY
QALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRALENATRDYFIICPIIDMASAWAKRARGNVFMYHAPENYGHGSLELLADVQF
ALGLPFYPAYEGQFSLEEKSLSLKIMQYFSHFIRSGNPNYPYEFSRKVPTFATPWPDFVPRAGGENYKEFSELLPNRQGLKKADCSFWSK

--------------------------------------------------------------
>56092_56092_9_MVB12B-TG_MVB12B_chr9_129102909_ENST00000545391_TG_chr8_134107288_ENST00000220616_length(transcript)=1456nt_BP=285nt
CGGTGAGGCTCGCGCTCGAGCTGCGGCGCCGGCTCCTGCCGCCTGGGCCCCGGGCCCGGCCCCTCCCGCGCCGCCCGGGCGATGAGAAGC
TGCTTCTGCGTGAGACGGAGCCGGGACCCGCCGCCGCCGCAGCCACCGCCGCCGCCGCCCCAGCGGGGAACAGACCAGTCCACCATGCCT
GAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCG
ACAGGCTATGACGTAGGAGGCTCCGCACTCTCCCCGGCCGCCGTCATCAGCCATGAGAGGGCTCAGCAGCAGGCAATTGCTTTGGCAAAG
GAGGTCAGTTGCCCCATGTCATCCAGCCAAGAAGTGGTGTCCTGCCTCCGCCAGAAGCCTGCCAATGTCCTCAATGATGCCCAGACCAAG
CTCCTGGCCGTGAGTGGCCCTTTCCACTACTGGGGTCCTGTGATCGATGGCCACTTCCTCCGTGAGCCTCCAGCCAGAGCACTGAAGAGG
TCTTTATGGGTAGAGGTCGATCTGCTCATTGGGAGTTCTCAGGACGACGGGCTCATCAACAGAGCAAAGGCTGTGAAGCAATTTGAGGAA
AGTCGAGGCCGGACCAGTAGCAAAACAGCCTTTTACCAGGCACTGCAGAATTCTCTGGGTGGCGAGGACTCAGATGCCCGCGTCGAGGCT
GCTGCTACATGGTATTACTCTCTGGAGCACTCCACGGATGACTATGCCTCCTTCTCCCGGGCTCTGGAGAATGCCACCCGGGACTACTTT
ATCATCTGCCCTATAATCGACATGGCCAGTGCCTGGGCAAAGAGGGCCCGAGGAAACGTCTTCATGTACCATGCTCCTGAAAACTACGGC
CATGGCAGCCTGGAGCTGCTGGCGGATGTTCAGTTTGCCTTGGGGCTTCCCTTCTACCCAGCCTACGAGGGGCAGTTTTCTCTGGAGGAG
AAGAGCCTGTCGCTGAAAATCATGCAGTACTTTTCCCACTTCATCAGATCAGGAAATCCCAACTACCCTTATGAGTTCTCACGGAAAGTA
CCCACATTTGCAACCCCCTGGCCTGACTTTGTACCCCGTGCTGGTGGAGAGAACTACAAGGAGTTCAGTGAGCTGCTCCCCAATCGACAG
GGCCTGAAGAAAGCCGACTGCTCCTTCTGGTCCAAGTACATCTCGTCTCTGAAGACATCTGCAGATGGAGCCAAGGGCGGGCAGTCAGCA
GAGAGTGAAGAGGAGGAGTTGACGGCTGGATCTGGGCTAAGAGAAGATCTCCTAAGCCTCCAGGAACCAGGCTCTAAGACCTACAGCAAG
TGACCAGCCCTTGAGCTCCCCAAAAACCTCACCCGAGGCTGCCCACTATGGTCATCTTTTTCTCTAAAATAGCCACTTACCTTCAATAAA

>56092_56092_9_MVB12B-TG_MVB12B_chr9_129102909_ENST00000545391_TG_chr8_134107288_ENST00000220616_length(amino acids)=436AA_BP=81
MGPGPGPSRAARAMRSCFCVRRSRDPPPPQPPPPPPQRGTDQSTMPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVGGSALSPAA
VISHERAQQQAIALAKEVSCPMSSSQEVVSCLRQKPANVLNDAQTKLLAVSGPFHYWGPVIDGHFLREPPARALKRSLWVEVDLLIGSSQ
DDGLINRAKAVKQFEESRGRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRALENATRDYFIICPIIDMASAWAK
RARGNVFMYHAPENYGHGSLELLADVQFALGLPFYPAYEGQFSLEEKSLSLKIMQYFSHFIRSGNPNYPYEFSRKVPTFATPWPDFVPRA

--------------------------------------------------------------
>56092_56092_10_MVB12B-TG_MVB12B_chr9_129102909_ENST00000545391_TG_chr8_134107288_ENST00000377869_length(transcript)=1458nt_BP=285nt
CGGTGAGGCTCGCGCTCGAGCTGCGGCGCCGGCTCCTGCCGCCTGGGCCCCGGGCCCGGCCCCTCCCGCGCCGCCCGGGCGATGAGAAGC
TGCTTCTGCGTGAGACGGAGCCGGGACCCGCCGCCGCCGCAGCCACCGCCGCCGCCGCCCCAGCGGGGAACAGACCAGTCCACCATGCCT
GAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCG
ACAGGCTATGACGTAGGAGGCTCCGCACTCTCCCCGGCCGCCGTCATCAGCCATGAGAGGGCTCAGCAGCAGGCAATTGCTTTGGCAAAG
GAGGTCAGTTGCCCCATGTCATCCAGCCAAGAAGTGGTGTCCTGCCTCCGCCAGAAGCCTGCCAATGTCCTCAATGATGCCCAGACCAAG
CTCCTGGCCGTGAGTGGCCCTTTCCACTACTGGGGTCCTGTGATCGATGGCCACTTCCTCCGTGAGCCTCCAGCCAGAGCACTGAAGAGG
TCTTTATGGGTAGAGGTCGATCTGCTCATTGGGAGTTCTCAGGACGACGGGCTCATCAACAGAGCAAAGGCTGTGAAGCAATTTGAGGAA
AGTCGAGGCCGGACCAGTAGCAAAACAGCCTTTTACCAGGCACTGCAGAATTCTCTGGGTGGCGAGGACTCAGATGCCCGCGTCGAGGCT
GCTGCTACATGGTATTACTCTCTGGAGCACTCCACGGATGACTATGCCTCCTTCTCCCGGGCTCTGGAGAATGCCACCCGGGACTACTTT
ATCATCTGCCCTATAATCGACATGGCCAGTGCCTGGGCAAAGAGGGCCCGAGGAAACGTCTTCATGTACCATGCTCCTGAAAACTACGGC
CATGGCAGCCTGGAGCTGCTGGCGGATGTTCAGTTTGCCTTGGGGCTTCCCTTCTACCCAGCCTACGAGGGGCAGTTTTCTCTGGAGGAG
AAGAGCCTGTCGCTGAAAATCATGCAGTACTTTTCCCACTTCATCAGATCAGGAAATCCCAACTACCCTTATGAGTTCTCACGGAAAGTA
CCCACATTTGCAACCCCCTGGCCTGACTTTGTACCCCGTGCTGGTGGAGAGAACTACAAGGAGTTCAGTGAGCTGCTCCCCAATCGACAG
GGCCTGAAGAAAGCCGACTGCTCCTTCTGGTCCAAGTACATCTCGTCTCTGAAGACATCTGCAGATGGAGCCAAGGGCGGGCAGTCAGCA
GAGAGTGAAGAGGAGGAGTTGACGGCTGGATCTGGGCTAAGAGAAGATCTCCTAAGCCTCCAGGAACCAGGCTCTAAGACCTACAGCAAG
TGACCAGCCCTTGAGCTCCCCAAAAACCTCACCCGAGGCTGCCCACTATGGTCATCTTTTTCTCTAAAATAGCCACTTACCTTCAATAAA

>56092_56092_10_MVB12B-TG_MVB12B_chr9_129102909_ENST00000545391_TG_chr8_134107288_ENST00000377869_length(amino acids)=436AA_BP=81
MGPGPGPSRAARAMRSCFCVRRSRDPPPPQPPPPPPQRGTDQSTMPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVGGSALSPAA
VISHERAQQQAIALAKEVSCPMSSSQEVVSCLRQKPANVLNDAQTKLLAVSGPFHYWGPVIDGHFLREPPARALKRSLWVEVDLLIGSSQ
DDGLINRAKAVKQFEESRGRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRALENATRDYFIICPIIDMASAWAK
RARGNVFMYHAPENYGHGSLELLADVQFALGLPFYPAYEGQFSLEEKSLSLKIMQYFSHFIRSGNPNYPYEFSRKVPTFATPWPDFVPRA

--------------------------------------------------------------
>56092_56092_11_MVB12B-TG_MVB12B_chr9_129102909_ENST00000545391_TG_chr8_134107288_ENST00000519543_length(transcript)=1462nt_BP=285nt
CGGTGAGGCTCGCGCTCGAGCTGCGGCGCCGGCTCCTGCCGCCTGGGCCCCGGGCCCGGCCCCTCCCGCGCCGCCCGGGCGATGAGAAGC
TGCTTCTGCGTGAGACGGAGCCGGGACCCGCCGCCGCCGCAGCCACCGCCGCCGCCGCCCCAGCGGGGAACAGACCAGTCCACCATGCCT
GAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCG
ACAGGCTATGACGTAGGAGGCTCCGCACTCTCCCCGGCCGCCGTCATCAGCCATGAGAGGGCTCAGCAGCAGGCAATTGCTTTGGCAAAG
GAGGTCAGTTGCCCCATGTCATCCAGCCAAGAAGTGGTGTCCTGCCTCCGCCAGAAGCCTGCCAATGTCCTCAATGATGCCCAGACCAAG
CTCCTGGCCGTGAGTGGCCCTTTCCACTACTGGGGTCCTGTGATCGATGGCCACTTCCTCCGTGAGCCTCCAGCCAGAGCACTGAAGAGG
TCTTTATGGGTAGAGGTCGATCTGCTCATTGGGAGTTCTCAGGACGACGGGCTCATCAACAGAGCAAAGGCTGTGAAGCAATTTGAGGAA
AGTCGAGGCCGGACCAGTAGCAAAACAGCCTTTTACCAGGCACTGCAGAATTCTCTGGGTGGCGAGGACTCAGATGCCCGCGTCGAGGCT
GCTGCTACATGGTATTACTCTCTGGAGCACTCCACGGATGACTATGCCTCCTTCTCCCGGGCTCTGGAGAATGCCACCCGGGACTACTTT
ATCATCTGCCCTATAATCGACATGGCCAGTGCCTGGGCAAAGAGGGCCCGAGGAAACGTCTTCATGTACCATGCTCCTGAAAACTACGGC
CATGGCAGCCTGGAGCTGCTGGCGGATGTTCAGTTTGCCTTGGGGCTTCCCTTCTACCCAGCCTACGAGGGGCAGTTTTCTCTGGAGGAG
AAGAGCCTGTCGCTGAAAATCATGCAGTACTTTTCCCACTTCATCAGATCAGGAAATCCCAACTACCCTTATGAGTTCTCACGGAAAGTA
CCCACATTTGCAACCCCCTGGCCTGACTTTGTACCCCGTGCTGGTGGAGAGAACTACAAGGAGTTCAGTGAGCTGCTCCCCAATCGACAG
GGCCTGAAGAAAGCCGACTGCTCCTTCTGGTCCAAGTACATCTCGTCTCTGAAGACATCTGCAGATGGAGCCAAGGGCGGGCAGTCAGCA
GAGAGTGAAGAGGAGGAGTTGACGGCTGGATCTGGGCTAAGAGAAGATCTCCTAAGCCTCCAGGAACCAGGCTCTAAGACCTACAGCAAG
TGACCAGCCCTTGAGCTCCCCAAAAACCTCACCCGAGGCTGCCCACTATGGTCATCTTTTTCTCTAAAATAGCCACTTACCTTCAATAAA

>56092_56092_11_MVB12B-TG_MVB12B_chr9_129102909_ENST00000545391_TG_chr8_134107288_ENST00000519543_length(amino acids)=436AA_BP=81
MGPGPGPSRAARAMRSCFCVRRSRDPPPPQPPPPPPQRGTDQSTMPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVGGSALSPAA
VISHERAQQQAIALAKEVSCPMSSSQEVVSCLRQKPANVLNDAQTKLLAVSGPFHYWGPVIDGHFLREPPARALKRSLWVEVDLLIGSSQ
DDGLINRAKAVKQFEESRGRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRALENATRDYFIICPIIDMASAWAK
RARGNVFMYHAPENYGHGSLELLADVQFALGLPFYPAYEGQFSLEEKSLSLKIMQYFSHFIRSGNPNYPYEFSRKVPTFATPWPDFVPRA

--------------------------------------------------------------
>56092_56092_12_MVB12B-TG_MVB12B_chr9_129102909_ENST00000545391_TG_chr8_134107288_ENST00000542445_length(transcript)=1386nt_BP=285nt
CGGTGAGGCTCGCGCTCGAGCTGCGGCGCCGGCTCCTGCCGCCTGGGCCCCGGGCCCGGCCCCTCCCGCGCCGCCCGGGCGATGAGAAGC
TGCTTCTGCGTGAGACGGAGCCGGGACCCGCCGCCGCCGCAGCCACCGCCGCCGCCGCCCCAGCGGGGAACAGACCAGTCCACCATGCCT
GAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAATGGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCG
ACAGGCTATGACGTAGGAGGCTCCGCACTCTCCCCGGCCGCCGTCATCAGCCATGAGAGGGCTCAGCAGCAGGCAATTGCTTTGGCAAAG
GAGGTCAGTTGCCCCATGTCATCCAGCCAAGAAGTGGTGTCCTGCCTCCGCCAGAAGCCTGCCAATGTCCTCAATGATGCCCAGACCAAG
CTCCTGGCCGTGAGTGGCCCTTTCCACTACTGGGGTCCTGTGATCGATGGCCACTTCCTCCGTGAGCCTCCAGCCAGAGCACTGAAGAGG
TCTTTATGGGTAGAGGTCGATCTGCTCATTGGGAGTTCTCAGGACGACGGGCTCATCAACAGAGCAAAGGCTGTGAAGCAATTTGAGGAA
AGTCGAGGCCGGACCAGTAGCAAAACAGCCTTTTACCAGGCACTGCAGAATTCTCTGGGTGGCGAGGACTCAGATGCCCGCGTCGAGGCT
GCTGCTACATGGTATTACTCTCTGGAGCACTCCACGGATGACTATGCCTCCTTCTCCCGGGCTCTGGAGAATGCCACCCGGGACTACTTT
ATCATCTGCCCTATAATCGACATGGCCAGTGCCTGGGCAAAGAGGGCCCGAGGAAACGTCTTCATGTACCATGCTCCTGAAAACTACGGC
CATGGCAGCCTGGAGCTGCTGGCGGATGTTCAGTTTGCCTTGGGGCTTCCCTTCTACCCAGCCTACGAGGGGCAGTTTTCTCTGGAGGAG
AAGAGCCTGTCGCTGAAAATCATGCAGTACTTTTCCCACTTCATCAGATCAGGAAATCCCAACTACCCTTATGAGTTCTCACGGAAAGTA
CCCACATTTGCAACCCCCTGGCCTGACTTTGTACCCCGTGCTGGTGGAGAGAACTACAAGGAGTTCAGTGAGCTGCTCCCCAATCGACAG
GGCCTGAAGAAAGCCGACTGCTCCTTCTGGTCCAAGTACATCTCGTCTCTGAAGACATCTGCAGATGGAGCCAAGGGCGGGCAGTCAGCA
GAGAGTGAAGAGGAGGAGTTGACGGCTGGATCTGGGCTAAGAGAAGATCTCCTAAGCCTCCAGGAACCAGGCTCTAAGACCTACAGCAAG

>56092_56092_12_MVB12B-TG_MVB12B_chr9_129102909_ENST00000545391_TG_chr8_134107288_ENST00000542445_length(amino acids)=436AA_BP=81
MGPGPGPSRAARAMRSCFCVRRSRDPPPPQPPPPPPQRGTDQSTMPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVGGSALSPAA
VISHERAQQQAIALAKEVSCPMSSSQEVVSCLRQKPANVLNDAQTKLLAVSGPFHYWGPVIDGHFLREPPARALKRSLWVEVDLLIGSSQ
DDGLINRAKAVKQFEESRGRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRALENATRDYFIICPIIDMASAWAK
RARGNVFMYHAPENYGHGSLELLADVQFALGLPFYPAYEGQFSLEEKSLSLKIMQYFSHFIRSGNPNYPYEFSRKVPTFATPWPDFVPRA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MVB12B-TG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MVB12B-TG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for MVB12B-TG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource