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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MVP-AP1B1 (FusionGDB2 ID:56101)

Fusion Gene Summary for MVP-AP1B1

check button Fusion gene summary
Fusion gene informationFusion gene name: MVP-AP1B1
Fusion gene ID: 56101
HgeneTgene
Gene symbol

MVP

AP1B1

Gene ID

9961

162

Gene namemajor vault proteinadaptor related protein complex 1 subunit beta 1
SynonymsLRP|VAULT1ADTB1|AP105A|BAM22|CLAPB2|KIDAR
Cytomap

16p11.2

22q12.2

Type of geneprotein-codingprotein-coding
Descriptionmajor vault proteinlung resistance-related proteintesticular secretory protein Li 30AP-1 complex subunit beta-1ADTB1, CLAPB2Golgi adaptor HA1/AP1 adaptin beta subunitadapter-related protein complex 1 subunit beta-1adaptor protein complex AP-1 subunit beta-1adaptor related protein complex 1 beta 1 subunitbeta-1-adaptinbeta-adaptin
Modification date2020031320200313
UniProtAcc

Q14764

Q10567

Ensembl transtripts involved in fusion geneENST00000357402, ENST00000395353, 
ENST00000452209, ENST00000566554, 
ENST00000472057, ENST00000317368, 
ENST00000356015, ENST00000357586, 
ENST00000402502, ENST00000405198, 
ENST00000415447, ENST00000432560, 
Fusion gene scores* DoF score9 X 10 X 6=5408 X 9 X 4=288
# samples 139
** MAII scorelog2(13/540*10)=-2.05444778402238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/288*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MVP [Title/Abstract] AND AP1B1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMVP(29859133)-AP1B1(29754725), # samples:1
Anticipated loss of major functional domain due to fusion event.MVP-AP1B1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMVP

GO:0023057

negative regulation of signaling

16441665

HgeneMVP

GO:0031953

negative regulation of protein autophosphorylation

16441665

HgeneMVP

GO:0038127

ERBB signaling pathway

15133037

HgeneMVP

GO:0061099

negative regulation of protein tyrosine kinase activity

16441665


check buttonFusion gene breakpoints across MVP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AP1B1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAI394032MVPchr16

29859133

-AP1B1chr22

29754725

+


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Fusion Gene ORF analysis for MVP-AP1B1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000357402ENST00000472057MVPchr16

29859133

-AP1B1chr22

29754725

+
5CDS-intronENST00000395353ENST00000472057MVPchr16

29859133

-AP1B1chr22

29754725

+
Frame-shiftENST00000395353ENST00000317368MVPchr16

29859133

-AP1B1chr22

29754725

+
Frame-shiftENST00000395353ENST00000356015MVPchr16

29859133

-AP1B1chr22

29754725

+
Frame-shiftENST00000395353ENST00000357586MVPchr16

29859133

-AP1B1chr22

29754725

+
Frame-shiftENST00000395353ENST00000402502MVPchr16

29859133

-AP1B1chr22

29754725

+
Frame-shiftENST00000395353ENST00000405198MVPchr16

29859133

-AP1B1chr22

29754725

+
Frame-shiftENST00000395353ENST00000415447MVPchr16

29859133

-AP1B1chr22

29754725

+
Frame-shiftENST00000395353ENST00000432560MVPchr16

29859133

-AP1B1chr22

29754725

+
In-frameENST00000357402ENST00000317368MVPchr16

29859133

-AP1B1chr22

29754725

+
In-frameENST00000357402ENST00000356015MVPchr16

29859133

-AP1B1chr22

29754725

+
In-frameENST00000357402ENST00000357586MVPchr16

29859133

-AP1B1chr22

29754725

+
In-frameENST00000357402ENST00000402502MVPchr16

29859133

-AP1B1chr22

29754725

+
In-frameENST00000357402ENST00000405198MVPchr16

29859133

-AP1B1chr22

29754725

+
In-frameENST00000357402ENST00000415447MVPchr16

29859133

-AP1B1chr22

29754725

+
In-frameENST00000357402ENST00000432560MVPchr16

29859133

-AP1B1chr22

29754725

+
intron-3CDSENST00000452209ENST00000317368MVPchr16

29859133

-AP1B1chr22

29754725

+
intron-3CDSENST00000452209ENST00000356015MVPchr16

29859133

-AP1B1chr22

29754725

+
intron-3CDSENST00000452209ENST00000357586MVPchr16

29859133

-AP1B1chr22

29754725

+
intron-3CDSENST00000452209ENST00000402502MVPchr16

29859133

-AP1B1chr22

29754725

+
intron-3CDSENST00000452209ENST00000405198MVPchr16

29859133

-AP1B1chr22

29754725

+
intron-3CDSENST00000452209ENST00000415447MVPchr16

29859133

-AP1B1chr22

29754725

+
intron-3CDSENST00000452209ENST00000432560MVPchr16

29859133

-AP1B1chr22

29754725

+
intron-3CDSENST00000566554ENST00000317368MVPchr16

29859133

-AP1B1chr22

29754725

+
intron-3CDSENST00000566554ENST00000356015MVPchr16

29859133

-AP1B1chr22

29754725

+
intron-3CDSENST00000566554ENST00000357586MVPchr16

29859133

-AP1B1chr22

29754725

+
intron-3CDSENST00000566554ENST00000402502MVPchr16

29859133

-AP1B1chr22

29754725

+
intron-3CDSENST00000566554ENST00000405198MVPchr16

29859133

-AP1B1chr22

29754725

+
intron-3CDSENST00000566554ENST00000415447MVPchr16

29859133

-AP1B1chr22

29754725

+
intron-3CDSENST00000566554ENST00000432560MVPchr16

29859133

-AP1B1chr22

29754725

+
intron-intronENST00000452209ENST00000472057MVPchr16

29859133

-AP1B1chr22

29754725

+
intron-intronENST00000566554ENST00000472057MVPchr16

29859133

-AP1B1chr22

29754725

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000357402MVPchr1629859133-ENST00000356015AP1B1chr2229754725+626828141202768882
ENST00000357402MVPchr1629859133-ENST00000432560AP1B1chr2229754725+625928141202768882
ENST00000357402MVPchr1629859133-ENST00000357586AP1B1chr2229754725+628928141202768882
ENST00000357402MVPchr1629859133-ENST00000405198AP1B1chr2229754725+610628141202768882
ENST00000357402MVPchr1629859133-ENST00000317368AP1B1chr2229754725+601628141202768882
ENST00000357402MVPchr1629859133-ENST00000402502AP1B1chr2229754725+520328141202768882
ENST00000357402MVPchr1629859133-ENST00000415447AP1B1chr2229754725+512028141202768882

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000357402ENST00000356015MVPchr1629859133-AP1B1chr2229754725+0.0071952660.9928047
ENST00000357402ENST00000432560MVPchr1629859133-AP1B1chr2229754725+0.0073009220.9926991
ENST00000357402ENST00000357586MVPchr1629859133-AP1B1chr2229754725+0.0071930860.9928069
ENST00000357402ENST00000405198MVPchr1629859133-AP1B1chr2229754725+0.0079627560.9920372
ENST00000357402ENST00000317368MVPchr1629859133-AP1B1chr2229754725+0.0079857580.9920142
ENST00000357402ENST00000402502MVPchr1629859133-AP1B1chr2229754725+0.0115900080.98841
ENST00000357402ENST00000415447MVPchr1629859133-AP1B1chr2229754725+0.0115390880.9884609

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Fusion Genomic Features for MVP-AP1B1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MVP-AP1B1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:29859133/chr22:29754725)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MVP

Q14764

AP1B1

Q10567

FUNCTION: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. {ECO:0000269|PubMed:15133037, ECO:0000269|PubMed:16418217, ECO:0000269|PubMed:16441665}.FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes (PubMed:31630791). The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. {ECO:0000269|PubMed:31630791}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAP1B1chr16:29859133chr22:29754725ENST00000317368021576_7250920.0Compositional biasNote=Pro-rich (stalk region)
TgeneAP1B1chr16:29859133chr22:29754725ENST00000356015022576_7250943.0Compositional biasNote=Pro-rich (stalk region)
TgeneAP1B1chr16:29859133chr22:29754725ENST00000357586023576_7250950.0Compositional biasNote=Pro-rich (stalk region)
TgeneAP1B1chr16:29859133chr22:29754725ENST00000402502020576_7250940.0Compositional biasNote=Pro-rich (stalk region)
TgeneAP1B1chr16:29859133chr22:29754725ENST00000405198022576_7250950.0Compositional biasNote=Pro-rich (stalk region)
TgeneAP1B1chr16:29859133chr22:29754725ENST00000415447020576_7250940.0Compositional biasNote=Pro-rich (stalk region)
TgeneAP1B1chr16:29859133chr22:29754725ENST00000432560021576_7250940.0Compositional biasNote=Pro-rich (stalk region)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMVPchr16:29859133chr22:29754725ENST00000357402-115112_1640894.0RepeatNote=MVP 3
HgeneMVPchr16:29859133chr22:29754725ENST00000357402-115165_2170894.0RepeatNote=MVP 4
HgeneMVPchr16:29859133chr22:29754725ENST00000357402-115218_2720894.0RepeatNote=MVP 5
HgeneMVPchr16:29859133chr22:29754725ENST00000357402-115273_3230894.0RepeatNote=MVP 6
HgeneMVPchr16:29859133chr22:29754725ENST00000357402-1152_560894.0RepeatNote=MVP 1
HgeneMVPchr16:29859133chr22:29754725ENST00000357402-115324_3790894.0RepeatNote=MVP 7
HgeneMVPchr16:29859133chr22:29754725ENST00000357402-115380_4570894.0RepeatNote=MVP 8
HgeneMVPchr16:29859133chr22:29754725ENST00000357402-115458_5200894.0RepeatNote=MVP 9
HgeneMVPchr16:29859133chr22:29754725ENST00000357402-11557_1110894.0RepeatNote=MVP 2
HgeneMVPchr16:29859133chr22:29754725ENST00000395353-115112_1640894.0RepeatNote=MVP 3
HgeneMVPchr16:29859133chr22:29754725ENST00000395353-115165_2170894.0RepeatNote=MVP 4
HgeneMVPchr16:29859133chr22:29754725ENST00000395353-115218_2720894.0RepeatNote=MVP 5
HgeneMVPchr16:29859133chr22:29754725ENST00000395353-115273_3230894.0RepeatNote=MVP 6
HgeneMVPchr16:29859133chr22:29754725ENST00000395353-1152_560894.0RepeatNote=MVP 1
HgeneMVPchr16:29859133chr22:29754725ENST00000395353-115324_3790894.0RepeatNote=MVP 7
HgeneMVPchr16:29859133chr22:29754725ENST00000395353-115380_4570894.0RepeatNote=MVP 8
HgeneMVPchr16:29859133chr22:29754725ENST00000395353-115458_5200894.0RepeatNote=MVP 9
HgeneMVPchr16:29859133chr22:29754725ENST00000395353-11557_1110894.0RepeatNote=MVP 2


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Fusion Gene Sequence for MVP-AP1B1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>56101_56101_1_MVP-AP1B1_MVP_chr16_29859133_ENST00000357402_AP1B1_chr22_29754725_ENST00000317368_length(transcript)=6016nt_BP=2814nt
ACCCCTGGGCTTGGCCTGCCTTGCCCTGCCGGGAAGTGATCCCCAAGGCAGGGTGAGAGTTCCCCATCTGAGGCGTTTGTTGCAGCTACC
TGCACTTCTAGATTCATCTTCTTGTGAGCCCTGGGCTTAGGAGTCACCATGGCAACTGAAGAGTTCATCATCCGCATCCCCCCATACCAC
TATATCCATGTGCTGGACCAGAACAGCAACGTGTCCCGTGTGGAGGTCGGGCCAAAGACCTACATCCGGCAGGACAATGAGAGGGTACTG
TTTGCCCCCATGCGCATGGTGACCGTCCCCCCACGTCACTACTGCACAGTGGCCAACCCTGTGTCTCGGGATGCCCAGGGCTTGGTGCTG
TTTGATGTCACAGGGCAAGTTCGGCTTCGCCACGCTGACCTCGAGATCCGGCTGGCCCAGGACCCCTTCCCCCTGTACCCAGGGGAGGTG
CTGGAAAAGGACATCACACCCCTGCAGGTGGTTCTGCCCAACACTGCCCTCCATCTAAAGGCGCTGCTTGATTTTGAGGATAAAGATGGA
GACAAGGTGGTGGCAGGAGATGAGTGGCTTTTCGAGGGACCTGGCACGTACATCCCCCGGAAGGAAGTGGAGGTCGTGGAGATCATTCAG
GCCACCATCATCAGGCAGAACCAGGCTCTGCGGCTCAGGGCCCGCAAGGAGTGCTGGGACCGGGACGGCAAGGAGAGGGTGACAGGGGAA
GAATGGCTGGTCACCACAGTAGGGGCGTACCTCCCAGCGGTGTTTGAGGAGGTTCTGGATTTGGTGGACGCCGTCATCCTTACGGAAAAG
ACAGCCCTGCACCTCCGGGCTCGGCGGAACTTCCGGGACTTCAGGGGAGTGTCCCGCCGCACTGGGGAGGAGTGGCTGGTAACAGTGCAG
GACACAGAGGCCCACGTGCCAGATGTCCACGAGGAGGTGCTGGGGGTTGTGCCCATCACCACCCTGGGCCCCCACAACTACTGCGTGATT
CTCGACCCTGTCGGACCGGATGGCAAGAATCAGCTGGGGCAGAAGCGCGTGGTCAAGGGAGAGAAGTCTTTTTTCCTCCAGCCAGGAGAG
CAGCTGGAACAAGGCATCCAGGATGTGTATGTGCTGTCGGAGCAGCAGGGGCTGCTGCTGAGGGCCCTGCAGCCCCTGGAGGAGGGGGAG
GATGAGGAGAAGGTCTCACACCAGGCTGGGGACCACTGGCTCATCCGCGGACCCCTGGAGTATGTGCCATCTGCCAAAGTGGAGGTGGTG
GAGGAGCGCCAGGCCATCCCTCTAGACGAGAACGAGGGCATCTATGTGCAGGATGTCAAGACCGGAAAGGTGCGCGCTGTGATTGGAAGC
ACCTACATGCTGACCCAGGACGAAGTCCTGTGGGAGAAAGAGCTGCCTCCCGGGGTGGAGGAGCTGCTGAACAAGGGGCAGGACCCTCTG
GCAGACAGGGGTGAGAAGGACACAGCTAAGAGCCTCCAGCCCTTGGCGCCCCGGAACAAGACCCGTGTGGTCAGCTACCGCGTGCCCCAC
AACGCTGCGGTGCAGGTGTACGACTACCGAGAGAAGCGAGCCCGCGTGGTCTTCGGGCCTGAGCTGGTGTCGCTGGGTCCTGAGGAGCAG
TTCACAGTGTTGTCCCTCTCAGCTGGGCGGCCCAAGCGTCCCCATGCCCGCCGTGCGCTCTGCCTGCTGCTGGGGCCTGACTTCTTCACA
GACGTCATCACCATCGAAACGGCGGATCATGCCAGGCTGCAACTGCAGCTGGCCTACAACTGGCACTTTGAGGTGAATGACCGGAAGGAC
CCCCAAGAGACGGCCAAGCTCTTTTCAGTGCCAGACTTTGTAGGTGATGCCTGCAAAGCCATCGCATCCCGGGTGCGGGGGGCCGTGGCC
TCTGTCACTTTCGATGACTTCCATAAGAACTCAGCCCGCATCATTCGCACTGCTGTCTTTGGCTTTGAGACCTCGGAAGCGAAGGGCCCC
GATGGCATGGCCCTGCCCAGGCCCCGGGACCAGGCTGTCTTCCCCCAAAACGGGCTGGTGGTCAGCAGTGTGGACGTGCAGTCAGTGGAG
CCTGTGGATCAGAGGACCCGGGACGCCCTGCAACGCAGCGTCCAGCTGGCCATCGAGATCACCACCAACTCCCAGGAAGCGGCGGCCAAG
CATGAGGCTCAGAGACTGGAGCAGGAAGCCCGCGGCCGGCTTGAGCGGCAGAAGATCCTGGACCAGTCAGAAGCCGAGAAAGCTCGCAAG
GAACTTTTGGAGCTGGAGGCTCTGAGCATGGCCGTGGAGAGCACCGGGACTGCCAAGGCGGAGGCCGAGTCCCGTGCGGAGGCAGCCCGG
ATTGAGGGAGAAGGGTCCGTGCTGCAGGCCAAGCTAAAAGCACAGGCCTTGGCCATTGAAACGGAGGCTGAGCTCCAGAGGGTCCAGAAG
GTCCGAGAGCTGGAACTGGTCTATGCCCGGGCCCAGCTGGAGCTGGAGGTGAGCAAGGCTCAGCAGCTGGCTGAGGTGGAGGTGAAGAAG
TTCAAGCAGATGACAGAGGCCATAGGCCCCAGCACCATCAGGGACCTTGCTGTGGCTGGGCCTGAGATGCAGTCCACTCCCATCAACCTC
TTCAACACAGCCTTTGGGCTGCTGGGGATGGGGCCCGAGGGTCAGCCCCTGGGCAGAAGGGTGGCCAGTGGGCCCAGCCCTGGGGAGGGG
ATATCCCCCCAGTCTGCTCAGGCCCCTCAAGCTCCTGGAGACAACCACGTGGTGCCTGTACTGCGCTAACTCCTGATTAATACAATGGAA
GTTTCTGGGCATTTACAATTTCAACTGTCCCTGAAGTGTCGAGCACCAGAGGTGTCCCAGCACGTGTACCAGGCCTACGAGACCATCCTC
AAGAACTGAGACCCCGGCCAGCGCCCACCCCAGCCTTCTGCCCGCCCCATCGAGGAGGCCCCTCGGGGGCAGCACATCTTCCTCCTCGCA
GGAGGGACCAGGCGGGGCTCCAGGCCACTCAGTGGGCTCCCTGGTCCTGATGGCAGAACCCACCCGATCCCTGGGGTAGGGCACCACCCC
CTCCTGGGGTGAGAGCGCAGTGCACTCCCGTGCTCTGGGACACCCCTGCTCCTGTGGCTGTGATGTGGGGTTAAGTGAGGTGGGGACCAA
AGGAAACAGAGCCAGAGCAGCCACAGAAGCTGTGCCTGAAGGGTGAGTGTGGAGCTTGCCCCTCCGGCTCACAGCCCCGGCAGCCCCTGG
CTCCTTGGTCTCTCCGGTTGGTGTTAAAGGGCCCTCCACTGCCACCTCTCATGGGATGGACCCTGCCAACCTGGCCTGGGTGTGCAGGGA
GGGGTTCCCCTTGGTACCAGGAGAGCTGCTCACTTAGGGCCTGGGGCTCAAGGAGCTGTAGGTGCCGGCAGAGGGGCAGAGCTAGGCTGG
GAGGAGCCCAGGGCCTGCACCACCCACTTGCAACCACCAGGCTGGTGCCCTGCAGCTGTGCCAGTTGGGCCACAGCCTCCCGAGTGCTGA
CCCACATGGTCAAGACCAGGCAGAAGCTCCCAGAGCCCCTGTCTCGGGCTCCCCACCGACTGGCAGCTGCACTATCCCCAACTCCCCACT
TCTGCCCCAAGGGTGGTCACTGCCTGTGATACATTCCTCAGTGTCGCCTCTGAGCCCAGGCCTCCTGCCACAAAGACTGGGCCGAGAGAT
GGGGCTGGGTAAGCGGGTGCGCCTCCTGTTTGGGTTTCTTCGGGGTTTCTCTGTAGTGTCTGCTGCCCTCCTCCTGGCCTCCCAGGTTTC
AGTTGTGTCTGACAGAGCATTAGGTTTTCCTGTTACTGCTGTGTAATAATAAAGAAAGATTCGGCAGGCTGCGAGCAGCAAGCTGCAGAG
CAGCAACATCTTCACTGTCGCCAAGAGGAACGTGGAGGGCCAGGACATGCTCTACCAGTCCCTGAAGCTGACCAACGGCATCTGGGTGCT
GGCGGAGCTGCGGATCCAGCCGGGCAACCCCAGCTGCACGACCGGCAGATGTTCCTGGCCACATGGAAGGATATTCCCAATGAGAATGAG
GCCCAGTTCCAGATCAGAGACTGCCCCCTCAATGCAGGTGGCCGTGAAGAACAACATCGATGTCTTCTACTTCAGCACCTTGTACCCACT
GCACATCCTCTTTGTGGAGGACGGGAAGATGGCTTTGGCCTGGCCCCCGCCACCCCCCTCCAGGTCCACGCGCCACTCAGCCCCAACCAG
ACAGTGGAGATCTCCCTGCCTCTCAGCACGGTGGGCTCGGTCATGAAGATGGAGCCTCTGAACAACCTCCAGGTGGGCTCCATCTCCATG
GACCTGCAGCTGACCAACAAGGCCTTGCAGGTCATGACCGACTTTGCCATCCAGTTCAACCGCAACAGATTGGGGGCACCAACTTCGTGG
CACCTCCAACAGCAGCAGTACCAGCCAATCTTGGAGCACCCATCGGCAGTGGCCTGAGTGACCTCTTTGACCTGACCAGTGGCGTGGGCA
CCCTGTCAGGATCATATGTGGCCCCCAAAGCAGAGTGAGAGCGCAGAGAGCCCTGAGACAGCCCCTACTGGAGCACCTCCTGGGGAGCAG
CCAGATGTCATCCCCGCCCAGGGCGACCTGCTGGGTGACCTCCTCAACCTGGACCTCGGCCCCCCAGTGAGCGGCCCACCCCTGGCCACC
TCCTCGGTGCAGATGGGAGCTGTGGACCTTCTTGGCGGTGGCCTTGACAGCCTGGACTCAGATAACCCAGACCTGCGGGACCGTGGCTAC
ATCTACTGGCGCCTGCTGTCCACGGACCCGGTGGCAGCCAAGGAGGTGGTGTTGGCTGAGAAGCCACTCATCTCTGAAGAGACGGACCTC
ATCGAGCCCACACTGTTAGACGAGCTTATCTGCTACATCGGCACGCTGGCTTCCGTCTACCATAAGCCTCCCAGTGCCTTTGTGGAGGGG
GGCCGGGGCGTCGTGCACAAGAGCCTGCCACCTCGCACGGCCTCGTCCAGCTGCAGCTGCTGACAGCCATTGTGAAACTCTTTCTAAAGA
AGCCAACAGAGACCCAGGAGCTGGTGCAGCAGGTCCTCAGTTTGGCCACTCAGGTATGAGAGTGTGATTGCCACACTGTGTGAGAATCTG
GACTCCCTGGATGAGCCTGAGGCCCGGGCTGCCATGATCTGGATTGTGGGCGAGTACGCGGAACGGATCGACAACGCAGATGAGCTGCTG
GAGAGCTTCCTCGAGGGCTTCCATGACGAGAGCACACAGCAATCTGCGGAGCGCTGTGTGAGCACGCTGCTCGACCTCATCCAGACCAAG
GTCAACTATGTGGTCCAGGAGGCCATCGTGGTCATCAAGGACATCTTCCGCAAGTACCCCAACAAGTGTTGGCAGAGCTGAAAGAGTACG
CAACAGAAGTGGATGTGGACTTTGTACGGAAGGCTGTGCGTGCTATTGGCCGCTGCGCCATCAAGGTGGAGGCCTGAGATCCTGAAGCAT
GAGATGAAGGTGTTCTTCGTGAAGTACAACGACCCTATCTACGTGAAGCTGGAGAAGCTGGACATCATGATCCGCCTGGCCTCTCAGGCC
AACATCGCCCAGCATCTGTGAGCGGGTCACCCCCAGGCTCTCCCATGCCAACTCCGCTGTGGTGCTCTCTGCTGTGAAGGTGCTGATGAA
GTTCATGGAGATGTTGTCTAAGGACTTGGACTACTACGGCACACTGCTCAAGAAGCTGGCCCCACCCCTGGTCACACTGCTGTCAGCCGA
GCCAGAGCTGCAGTATGTGGCCCTGCGCAACATCAATCTCATCGTGCAGAAAAGGTGGTGGCCAATGCAGTGGCAGCGCTCTCAGAAATT
GCCGAGTCTCACCCCAGCAGCAACCTGCTCGATCTGAACCCACAGTCCATCAACAAGCTGCTGACAGCCCTCAATGAGTGCACCGAGTGG

>56101_56101_1_MVP-AP1B1_MVP_chr16_29859133_ENST00000357402_AP1B1_chr22_29754725_ENST00000317368_length(amino acids)=882AA_BP=
MGLGVTMATEEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCTVANPVSRDAQGLVLFDVTGQVRLR
HADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTALHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEIIQATIIRQNQAL
RLRARKECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRDFRGVSRRTGEEWLVTVQDTEAHVPDVH
EEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKRVVKGEKSFFLQPGEQLEQGIQDVYVLSEQQGLLLRALQPLEEGEDEEKVSHQAG
DHWLIRGPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLADRGEKDTAK
SLQPLAPRNKTRVVSYRVPHNAAVQVYDYREKRARVVFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADH
ARLQLQLAYNWHFEVNDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGFETSEAKGPDGMALPRPRD
QAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSM
AVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAIGP

--------------------------------------------------------------
>56101_56101_2_MVP-AP1B1_MVP_chr16_29859133_ENST00000357402_AP1B1_chr22_29754725_ENST00000356015_length(transcript)=6268nt_BP=2814nt
ACCCCTGGGCTTGGCCTGCCTTGCCCTGCCGGGAAGTGATCCCCAAGGCAGGGTGAGAGTTCCCCATCTGAGGCGTTTGTTGCAGCTACC
TGCACTTCTAGATTCATCTTCTTGTGAGCCCTGGGCTTAGGAGTCACCATGGCAACTGAAGAGTTCATCATCCGCATCCCCCCATACCAC
TATATCCATGTGCTGGACCAGAACAGCAACGTGTCCCGTGTGGAGGTCGGGCCAAAGACCTACATCCGGCAGGACAATGAGAGGGTACTG
TTTGCCCCCATGCGCATGGTGACCGTCCCCCCACGTCACTACTGCACAGTGGCCAACCCTGTGTCTCGGGATGCCCAGGGCTTGGTGCTG
TTTGATGTCACAGGGCAAGTTCGGCTTCGCCACGCTGACCTCGAGATCCGGCTGGCCCAGGACCCCTTCCCCCTGTACCCAGGGGAGGTG
CTGGAAAAGGACATCACACCCCTGCAGGTGGTTCTGCCCAACACTGCCCTCCATCTAAAGGCGCTGCTTGATTTTGAGGATAAAGATGGA
GACAAGGTGGTGGCAGGAGATGAGTGGCTTTTCGAGGGACCTGGCACGTACATCCCCCGGAAGGAAGTGGAGGTCGTGGAGATCATTCAG
GCCACCATCATCAGGCAGAACCAGGCTCTGCGGCTCAGGGCCCGCAAGGAGTGCTGGGACCGGGACGGCAAGGAGAGGGTGACAGGGGAA
GAATGGCTGGTCACCACAGTAGGGGCGTACCTCCCAGCGGTGTTTGAGGAGGTTCTGGATTTGGTGGACGCCGTCATCCTTACGGAAAAG
ACAGCCCTGCACCTCCGGGCTCGGCGGAACTTCCGGGACTTCAGGGGAGTGTCCCGCCGCACTGGGGAGGAGTGGCTGGTAACAGTGCAG
GACACAGAGGCCCACGTGCCAGATGTCCACGAGGAGGTGCTGGGGGTTGTGCCCATCACCACCCTGGGCCCCCACAACTACTGCGTGATT
CTCGACCCTGTCGGACCGGATGGCAAGAATCAGCTGGGGCAGAAGCGCGTGGTCAAGGGAGAGAAGTCTTTTTTCCTCCAGCCAGGAGAG
CAGCTGGAACAAGGCATCCAGGATGTGTATGTGCTGTCGGAGCAGCAGGGGCTGCTGCTGAGGGCCCTGCAGCCCCTGGAGGAGGGGGAG
GATGAGGAGAAGGTCTCACACCAGGCTGGGGACCACTGGCTCATCCGCGGACCCCTGGAGTATGTGCCATCTGCCAAAGTGGAGGTGGTG
GAGGAGCGCCAGGCCATCCCTCTAGACGAGAACGAGGGCATCTATGTGCAGGATGTCAAGACCGGAAAGGTGCGCGCTGTGATTGGAAGC
ACCTACATGCTGACCCAGGACGAAGTCCTGTGGGAGAAAGAGCTGCCTCCCGGGGTGGAGGAGCTGCTGAACAAGGGGCAGGACCCTCTG
GCAGACAGGGGTGAGAAGGACACAGCTAAGAGCCTCCAGCCCTTGGCGCCCCGGAACAAGACCCGTGTGGTCAGCTACCGCGTGCCCCAC
AACGCTGCGGTGCAGGTGTACGACTACCGAGAGAAGCGAGCCCGCGTGGTCTTCGGGCCTGAGCTGGTGTCGCTGGGTCCTGAGGAGCAG
TTCACAGTGTTGTCCCTCTCAGCTGGGCGGCCCAAGCGTCCCCATGCCCGCCGTGCGCTCTGCCTGCTGCTGGGGCCTGACTTCTTCACA
GACGTCATCACCATCGAAACGGCGGATCATGCCAGGCTGCAACTGCAGCTGGCCTACAACTGGCACTTTGAGGTGAATGACCGGAAGGAC
CCCCAAGAGACGGCCAAGCTCTTTTCAGTGCCAGACTTTGTAGGTGATGCCTGCAAAGCCATCGCATCCCGGGTGCGGGGGGCCGTGGCC
TCTGTCACTTTCGATGACTTCCATAAGAACTCAGCCCGCATCATTCGCACTGCTGTCTTTGGCTTTGAGACCTCGGAAGCGAAGGGCCCC
GATGGCATGGCCCTGCCCAGGCCCCGGGACCAGGCTGTCTTCCCCCAAAACGGGCTGGTGGTCAGCAGTGTGGACGTGCAGTCAGTGGAG
CCTGTGGATCAGAGGACCCGGGACGCCCTGCAACGCAGCGTCCAGCTGGCCATCGAGATCACCACCAACTCCCAGGAAGCGGCGGCCAAG
CATGAGGCTCAGAGACTGGAGCAGGAAGCCCGCGGCCGGCTTGAGCGGCAGAAGATCCTGGACCAGTCAGAAGCCGAGAAAGCTCGCAAG
GAACTTTTGGAGCTGGAGGCTCTGAGCATGGCCGTGGAGAGCACCGGGACTGCCAAGGCGGAGGCCGAGTCCCGTGCGGAGGCAGCCCGG
ATTGAGGGAGAAGGGTCCGTGCTGCAGGCCAAGCTAAAAGCACAGGCCTTGGCCATTGAAACGGAGGCTGAGCTCCAGAGGGTCCAGAAG
GTCCGAGAGCTGGAACTGGTCTATGCCCGGGCCCAGCTGGAGCTGGAGGTGAGCAAGGCTCAGCAGCTGGCTGAGGTGGAGGTGAAGAAG
TTCAAGCAGATGACAGAGGCCATAGGCCCCAGCACCATCAGGGACCTTGCTGTGGCTGGGCCTGAGATGCAGTCCACTCCCATCAACCTC
TTCAACACAGCCTTTGGGCTGCTGGGGATGGGGCCCGAGGGTCAGCCCCTGGGCAGAAGGGTGGCCAGTGGGCCCAGCCCTGGGGAGGGG
ATATCCCCCCAGTCTGCTCAGGCCCCTCAAGCTCCTGGAGACAACCACGTGGTGCCTGTACTGCGCTAACTCCTGATTAATACAATGGAA
GTTTCTGGGCATTTACAATTTCAACTGTCCCTGAAGTGTCGAGCACCAGAGGTGTCCCAGCACGTGTACCAGGCCTACGAGACCATCCTC
AAGAACTGAGACCCCGGCCAGCGCCCACCCCAGCCTTCTGCCCGCCCCATCGAGGAGGCCCCTCGGGGGCAGCACATCTTCCTCCTCGCA
GGAGGGACCAGGCGGGGCTCCAGGCCACTCAGTGGGCTCCCTGGTCCTGATGGCAGAACCCACCCGATCCCTGGGGTAGGGCACCACCCC
CTCCTGGGGTGAGAGCGCAGTGCACTCCCGTGCTCTGGGACACCCCTGCTCCTGTGGCTGTGATGTGGGGTTAAGTGAGGTGGGGACCAA
AGGAAACAGAGCCAGAGCAGCCACAGAAGCTGTGCCTGAAGGGTGAGTGTGGAGCTTGCCCCTCCGGCTCACAGCCCCGGCAGCCCCTGG
CTCCTTGGTCTCTCCGGTTGGTGTTAAAGGGCCCTCCACTGCCACCTCTCATGGGATGGACCCTGCCAACCTGGCCTGGGTGTGCAGGGA
GGGGTTCCCCTTGGTACCAGGAGAGCTGCTCACTTAGGGCCTGGGGCTCAAGGAGCTGTAGGTGCCGGCAGAGGGGCAGAGCTAGGCTGG
GAGGAGCCCAGGGCCTGCACCACCCACTTGCAACCACCAGGCTGGTGCCCTGCAGCTGTGCCAGTTGGGCCACAGCCTCCCGAGTGCTGA
CCCACATGGTCAAGACCAGGCAGAAGCTCCCAGAGCCCCTGTCTCGGGCTCCCCACCGACTGGCAGCTGCACTATCCCCAACTCCCCACT
TCTGCCCCAAGGGTGGTCACTGCCTGTGATACATTCCTCAGTGTCGCCTCTGAGCCCAGGCCTCCTGCCACAAAGACTGGGCCGAGAGAT
GGGGCTGGGTAAGCGGGTGCGCCTCCTGTTTGGGTTTCTTCGGGGTTTCTCTGTAGTGTCTGCTGCCCTCCTCCTGGCCTCCCAGGTTTC
AGTTGTGTCTGACAGAGCATTAGGTTTTCCTGTTACTGCTGTGTAATAATAAAGAAAGATTCGGCTTTTGGCAATCACGGACACTTTTTT
CCCCTCCACCGAATGTCAGGATTGAAAGCTGCCTCCGAGTGGTTGGGGATGGTTTTCTGACCCTACGGTAACTAGATCTAATATATATCA
TCAGAAAATATATATTGTATGTTTACTCTTATTTTCAGAAAGAGAAAATGAATAAAAATGATGACATCGACTTAGAGAGGCTGCGAGCAG
CAAGCTGCAGAGCAGCAACATCTTCACTGTCGCCAAGAGGAACGTGGAGGGCCAGGACATGCTCTACCAGTCCCTGAAGCTGACCAACGG
CATCTGGGTGCTGGCGGAGCTGCGGATCCAGCCGGGCAACCCCAGCTGCACGACCGGCAGATGTTCCTGGCCACATGGAAGGATATTCCC
AATGAGAATGAGGCCCAGTTCCAGATCAGAGACTGCCCCCTCAATGCAGGTGGCCGTGAAGAACAACATCGATGTCTTCTACTTCAGCAC
CTTGTACCCACTGCACATCCTCTTTGTGGAGGACGGGAAGATGGCTTTGGCCTGGCCCCCGCCACCCCCCTCCAGGTCCACGCGCCACTC
AGCCCCAACCAGACAGTGGAGATCTCCCTGCCTCTCAGCACGGTGGGCTCGGTCATGAAGATGGAGCCTCTGAACAACCTCCAGGTCTGG
CTCCCAGCCATGAAGGCTAAGGGGCTGGAGATCTCAGGCACCTTCACCCGCCAGGTGGGCTCCATCTCCATGGACCTGCAGCTGACCAAC
AAGGCCTTGCAGGTCATGACCGACTTTGCCATCCAGTTCAACCGCAACAGATTGGGGGCACCAACTTCGTGGCACCTCCAACAGCAGCAG
TACCAGCCAATCTTGGAGCACCCATCGGCAGTGGCCTGAGTGACCTCTTTGACCTGACCAGTGGCGTGGGCACCCTGTCAGGATCATATG
TGGCCCCCAAAGCAGAGTGAGAGCGCAGAGAGCCCTGAGACAGCCCCTACTGGAGCACCTCCTGGGGAGCAGCCAGATGTCATCCCCGCC
CAGGGCGACCTGCTGGGTGACCTCCTCAACCTGGACCTCGGCCCCCCAGTGAGCGGCCCACCCCTGGCCACCTCCTCGGTGCAGATGGGA
GCTGTGGACCTTCTTGGCGGTGGCCTTGACAGCCTGGACTCAGATAACCCAGACCTGCGGGACCGTGGCTACATCTACTGGCGCCTGCTG
TCCACGGACCCGGTGGCAGCCAAGGAGGTGGTGTTGGCTGAGAAGCCACTCATCTCTGAAGAGACGGACCTCATCGAGCCCACACTGTTA
GACGAGCTTATCTGCTACATCGGCACGCTGGCTTCCGTCTACCATAAGCCTCCCAGTGCCTTTGTGGAGGGGGGCCGGGGCGTCGTGCAC
AAGAGCCTGCCACCTCGCACGGCCTCGTCCAGCTGCAGCTGCTGACAGCCATTGTGAAACTCTTTCTAAAGAAGCCAACAGAGACCCAGG
AGCTGGTGCAGCAGGTCCTCAGTTTGGCCACTCAGGTATGAGAGTGTGATTGCCACACTGTGTGAGAATCTGGACTCCCTGGATGAGCCT
GAGGCCCGGGCTGCCATGATCTGGATTGTGGGCGAGTACGCGGAACGGATCGACAACGCAGATGAGCTGCTGGAGAGCTTCCTCGAGGGC
TTCCATGACGAGAGCACACAGCAATCTGCGGAGCGCTGTGTGAGCACGCTGCTCGACCTCATCCAGACCAAGGTCAACTATGTGGTCCAG
GAGGCCATCGTGGTCATCAAGGACATCTTCCGCAAGTACCCCAACAAGTGTTGGCAGAGCTGAAAGAGTACGCAACAGAAGTGGATGTGG
ACTTTGTACGGAAGGCTGTGCGTGCTATTGGCCGCTGCGCCATCAAGGTGGAGGCCTGAGATCCTGAAGCATGAGATGAAGGTGTTCTTC
GTGAAGTACAACGACCCTATCTACGTGAAGCTGGAGAAGCTGGACATCATGATCCGCCTGGCCTCTCAGGCCAACATCGCCCAGCATCTG
TGAGCGGGTCACCCCCAGGCTCTCCCATGCCAACTCCGCTGTGGTGCTCTCTGCTGTGAAGGTGCTGATGAAGTTCATGGAGATGTTGTC
TAAGGACTTGGACTACTACGGCACACTGCTCAAGAAGCTGGCCCCACCCCTGGTCACACTGCTGTCAGCCGAGCCAGAGCTGCAGTATGT
GGCCCTGCGCAACATCAATCTCATCGTGCAGAAAAGGTGGTGGCCAATGCAGTGGCAGCGCTCTCAGAAATTGCCGAGTCTCACCCCAGC
AGCAACCTGCTCGATCTGAACCCACAGTCCATCAACAAGCTGCTGACAGCCCTCAATGAGTGCACCGAGTGGGGCCAGATCTTCATCCTG

>56101_56101_2_MVP-AP1B1_MVP_chr16_29859133_ENST00000357402_AP1B1_chr22_29754725_ENST00000356015_length(amino acids)=882AA_BP=
MGLGVTMATEEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCTVANPVSRDAQGLVLFDVTGQVRLR
HADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTALHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEIIQATIIRQNQAL
RLRARKECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRDFRGVSRRTGEEWLVTVQDTEAHVPDVH
EEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKRVVKGEKSFFLQPGEQLEQGIQDVYVLSEQQGLLLRALQPLEEGEDEEKVSHQAG
DHWLIRGPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLADRGEKDTAK
SLQPLAPRNKTRVVSYRVPHNAAVQVYDYREKRARVVFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADH
ARLQLQLAYNWHFEVNDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGFETSEAKGPDGMALPRPRD
QAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSM
AVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAIGP

--------------------------------------------------------------
>56101_56101_3_MVP-AP1B1_MVP_chr16_29859133_ENST00000357402_AP1B1_chr22_29754725_ENST00000357586_length(transcript)=6289nt_BP=2814nt
ACCCCTGGGCTTGGCCTGCCTTGCCCTGCCGGGAAGTGATCCCCAAGGCAGGGTGAGAGTTCCCCATCTGAGGCGTTTGTTGCAGCTACC
TGCACTTCTAGATTCATCTTCTTGTGAGCCCTGGGCTTAGGAGTCACCATGGCAACTGAAGAGTTCATCATCCGCATCCCCCCATACCAC
TATATCCATGTGCTGGACCAGAACAGCAACGTGTCCCGTGTGGAGGTCGGGCCAAAGACCTACATCCGGCAGGACAATGAGAGGGTACTG
TTTGCCCCCATGCGCATGGTGACCGTCCCCCCACGTCACTACTGCACAGTGGCCAACCCTGTGTCTCGGGATGCCCAGGGCTTGGTGCTG
TTTGATGTCACAGGGCAAGTTCGGCTTCGCCACGCTGACCTCGAGATCCGGCTGGCCCAGGACCCCTTCCCCCTGTACCCAGGGGAGGTG
CTGGAAAAGGACATCACACCCCTGCAGGTGGTTCTGCCCAACACTGCCCTCCATCTAAAGGCGCTGCTTGATTTTGAGGATAAAGATGGA
GACAAGGTGGTGGCAGGAGATGAGTGGCTTTTCGAGGGACCTGGCACGTACATCCCCCGGAAGGAAGTGGAGGTCGTGGAGATCATTCAG
GCCACCATCATCAGGCAGAACCAGGCTCTGCGGCTCAGGGCCCGCAAGGAGTGCTGGGACCGGGACGGCAAGGAGAGGGTGACAGGGGAA
GAATGGCTGGTCACCACAGTAGGGGCGTACCTCCCAGCGGTGTTTGAGGAGGTTCTGGATTTGGTGGACGCCGTCATCCTTACGGAAAAG
ACAGCCCTGCACCTCCGGGCTCGGCGGAACTTCCGGGACTTCAGGGGAGTGTCCCGCCGCACTGGGGAGGAGTGGCTGGTAACAGTGCAG
GACACAGAGGCCCACGTGCCAGATGTCCACGAGGAGGTGCTGGGGGTTGTGCCCATCACCACCCTGGGCCCCCACAACTACTGCGTGATT
CTCGACCCTGTCGGACCGGATGGCAAGAATCAGCTGGGGCAGAAGCGCGTGGTCAAGGGAGAGAAGTCTTTTTTCCTCCAGCCAGGAGAG
CAGCTGGAACAAGGCATCCAGGATGTGTATGTGCTGTCGGAGCAGCAGGGGCTGCTGCTGAGGGCCCTGCAGCCCCTGGAGGAGGGGGAG
GATGAGGAGAAGGTCTCACACCAGGCTGGGGACCACTGGCTCATCCGCGGACCCCTGGAGTATGTGCCATCTGCCAAAGTGGAGGTGGTG
GAGGAGCGCCAGGCCATCCCTCTAGACGAGAACGAGGGCATCTATGTGCAGGATGTCAAGACCGGAAAGGTGCGCGCTGTGATTGGAAGC
ACCTACATGCTGACCCAGGACGAAGTCCTGTGGGAGAAAGAGCTGCCTCCCGGGGTGGAGGAGCTGCTGAACAAGGGGCAGGACCCTCTG
GCAGACAGGGGTGAGAAGGACACAGCTAAGAGCCTCCAGCCCTTGGCGCCCCGGAACAAGACCCGTGTGGTCAGCTACCGCGTGCCCCAC
AACGCTGCGGTGCAGGTGTACGACTACCGAGAGAAGCGAGCCCGCGTGGTCTTCGGGCCTGAGCTGGTGTCGCTGGGTCCTGAGGAGCAG
TTCACAGTGTTGTCCCTCTCAGCTGGGCGGCCCAAGCGTCCCCATGCCCGCCGTGCGCTCTGCCTGCTGCTGGGGCCTGACTTCTTCACA
GACGTCATCACCATCGAAACGGCGGATCATGCCAGGCTGCAACTGCAGCTGGCCTACAACTGGCACTTTGAGGTGAATGACCGGAAGGAC
CCCCAAGAGACGGCCAAGCTCTTTTCAGTGCCAGACTTTGTAGGTGATGCCTGCAAAGCCATCGCATCCCGGGTGCGGGGGGCCGTGGCC
TCTGTCACTTTCGATGACTTCCATAAGAACTCAGCCCGCATCATTCGCACTGCTGTCTTTGGCTTTGAGACCTCGGAAGCGAAGGGCCCC
GATGGCATGGCCCTGCCCAGGCCCCGGGACCAGGCTGTCTTCCCCCAAAACGGGCTGGTGGTCAGCAGTGTGGACGTGCAGTCAGTGGAG
CCTGTGGATCAGAGGACCCGGGACGCCCTGCAACGCAGCGTCCAGCTGGCCATCGAGATCACCACCAACTCCCAGGAAGCGGCGGCCAAG
CATGAGGCTCAGAGACTGGAGCAGGAAGCCCGCGGCCGGCTTGAGCGGCAGAAGATCCTGGACCAGTCAGAAGCCGAGAAAGCTCGCAAG
GAACTTTTGGAGCTGGAGGCTCTGAGCATGGCCGTGGAGAGCACCGGGACTGCCAAGGCGGAGGCCGAGTCCCGTGCGGAGGCAGCCCGG
ATTGAGGGAGAAGGGTCCGTGCTGCAGGCCAAGCTAAAAGCACAGGCCTTGGCCATTGAAACGGAGGCTGAGCTCCAGAGGGTCCAGAAG
GTCCGAGAGCTGGAACTGGTCTATGCCCGGGCCCAGCTGGAGCTGGAGGTGAGCAAGGCTCAGCAGCTGGCTGAGGTGGAGGTGAAGAAG
TTCAAGCAGATGACAGAGGCCATAGGCCCCAGCACCATCAGGGACCTTGCTGTGGCTGGGCCTGAGATGCAGTCCACTCCCATCAACCTC
TTCAACACAGCCTTTGGGCTGCTGGGGATGGGGCCCGAGGGTCAGCCCCTGGGCAGAAGGGTGGCCAGTGGGCCCAGCCCTGGGGAGGGG
ATATCCCCCCAGTCTGCTCAGGCCCCTCAAGCTCCTGGAGACAACCACGTGGTGCCTGTACTGCGCTAACTCCTGATTAATACAATGGAA
GTTTCTGGGCATTTACAATTTCAACTGTCCCTGAAGTGTCGAGCACCAGAGGTGTCCCAGCACGTGTACCAGGCCTACGAGACCATCCTC
AAGAACTGAGACCCCGGCCAGCGCCCACCCCAGCCTTCTGCCCGCCCCATCGAGGAGGCCCCTCGGGGGCAGCACATCTTCCTCCTCGCA
GGAGGGACCAGGCGGGGCTCCAGGCCACTCAGTGGGCTCCCTGGTCCTGATGGCAGAACCCACCCGATCCCTGGGGTAGGGCACCACCCC
CTCCTGGGGTGAGAGCGCAGTGCACTCCCGTGCTCTGGGACACCCCTGCTCCTGTGGCTGTGATGTGGGGTTAAGTGAGGTGGGGACCAA
AGGAAACAGAGCCAGAGCAGCCACAGAAGCTGTGCCTGAAGGGTGAGTGTGGAGCTTGCCCCTCCGGCTCACAGCCCCGGCAGCCCCTGG
CTCCTTGGTCTCTCCGGTTGGTGTTAAAGGGCCCTCCACTGCCACCTCTCATGGGATGGACCCTGCCAACCTGGCCTGGGTGTGCAGGGA
GGGGTTCCCCTTGGTACCAGGAGAGCTGCTCACTTAGGGCCTGGGGCTCAAGGAGCTGTAGGTGCCGGCAGAGGGGCAGAGCTAGGCTGG
GAGGAGCCCAGGGCCTGCACCACCCACTTGCAACCACCAGGCTGGTGCCCTGCAGCTGTGCCAGTTGGGCCACAGCCTCCCGAGTGCTGA
CCCACATGGTCAAGACCAGGCAGAAGCTCCCAGAGCCCCTGTCTCGGGCTCCCCACCGACTGGCAGCTGCACTATCCCCAACTCCCCACT
TCTGCCCCAAGGGTGGTCACTGCCTGTGATACATTCCTCAGTGTCGCCTCTGAGCCCAGGCCTCCTGCCACAAAGACTGGGCCGAGAGAT
GGGGCTGGGTAAGCGGGTGCGCCTCCTGTTTGGGTTTCTTCGGGGTTTCTCTGTAGTGTCTGCTGCCCTCCTCCTGGCCTCCCAGGTTTC
AGTTGTGTCTGACAGAGCATTAGGTTTTCCTGTTACTGCTGTGTAATAATAAAGAAAGATTCGGCTTTTGGCAATCACGGACACTTTTTT
CCCCTCCACCGAATGTCAGGATTGAAAGCTGCCTCCGAGTGGTTGGGGATGGTTTTCTGACCCTACGGTAACTAGATCTAATATATATCA
TCAGAAAATATATATTGTATGTTTACTCTTATTTTCAGAAAGAGAAAATGAATAAAAATGATGACATCGACTTAGAGAGGCTGCGAGCAG
CAAGCTGCAGAGCAGCAACATCTTCACTGTCGCCAAGAGGAACGTGGAGGGCCAGGACATGCTCTACCAGTCCCTGAAGCTGACCAACGG
CATCTGGGTGCTGGCGGAGCTGCGGATCCAGCCGGGCAACCCCAGCTGCACGACCGGCAGATGTTCCTGGCCACATGGAAGGATATTCCC
AATGAGAATGAGGCCCAGTTCCAGATCAGAGACTGCCCCCTCAATGCAGGTGGCCGTGAAGAACAACATCGATGTCTTCTACTTCAGCAC
CTTGTACCCACTGCACATCCTCTTTGTGGAGGACGGGAAGATGGCTTTGGCCTGGCCCCCGCCACCCCCCTCCAGGTCCACGCGCCACTC
AGCCCCAACCAGACAGTGGAGATCTCCCTGCCTCTCAGCACGGTGGGCTCGGTCATGAAGATGGAGCCTCTGAACAACCTCCAGGTCTGG
CTCCCAGCCATGAAGGCTAAGGGGCTGGAGATCTCAGGCACCTTCACCCGCCAGGTGGGCTCCATCTCCATGGACCTGCAGCTGACCAAC
AAGGCCTTGCAGGTCATGACCGACTTTGCCATCCAGTTCAACCGCAACAGATTGGGGGCACCAACTTCGTGGCACCTCCAACAGCAGCAG
TACCAGCCAATCTTGGAGCACCCATCGGCAGTGGCCTGAGTGACCTCTTTGACCTGACCAGTGGCGTGGGCACCCTGTCAGGATCATATG
TGGCCCCCAAAGCAATGGGGGATGAGCCTGAAGGGGAGTGAGAGCGCAGAGAGCCCTGAGACAGCCCCTACTGGAGCACCTCCTGGGGAG
CAGCCAGATGTCATCCCCGCCCAGGGCGACCTGCTGGGTGACCTCCTCAACCTGGACCTCGGCCCCCCAGTGAGCGGCCCACCCCTGGCC
ACCTCCTCGGTGCAGATGGGAGCTGTGGACCTTCTTGGCGGTGGCCTTGACAGCCTGGACTCAGATAACCCAGACCTGCGGGACCGTGGC
TACATCTACTGGCGCCTGCTGTCCACGGACCCGGTGGCAGCCAAGGAGGTGGTGTTGGCTGAGAAGCCACTCATCTCTGAAGAGACGGAC
CTCATCGAGCCCACACTGTTAGACGAGCTTATCTGCTACATCGGCACGCTGGCTTCCGTCTACCATAAGCCTCCCAGTGCCTTTGTGGAG
GGGGGCCGGGGCGTCGTGCACAAGAGCCTGCCACCTCGCACGGCCTCGTCCAGCTGCAGCTGCTGACAGCCATTGTGAAACTCTTTCTAA
AGAAGCCAACAGAGACCCAGGAGCTGGTGCAGCAGGTCCTCAGTTTGGCCACTCAGGTATGAGAGTGTGATTGCCACACTGTGTGAGAAT
CTGGACTCCCTGGATGAGCCTGAGGCCCGGGCTGCCATGATCTGGATTGTGGGCGAGTACGCGGAACGGATCGACAACGCAGATGAGCTG
CTGGAGAGCTTCCTCGAGGGCTTCCATGACGAGAGCACACAGCAATCTGCGGAGCGCTGTGTGAGCACGCTGCTCGACCTCATCCAGACC
AAGGTCAACTATGTGGTCCAGGAGGCCATCGTGGTCATCAAGGACATCTTCCGCAAGTACCCCAACAAGTGTTGGCAGAGCTGAAAGAGT
ACGCAACAGAAGTGGATGTGGACTTTGTACGGAAGGCTGTGCGTGCTATTGGCCGCTGCGCCATCAAGGTGGAGGCCTGAGATCCTGAAG
CATGAGATGAAGGTGTTCTTCGTGAAGTACAACGACCCTATCTACGTGAAGCTGGAGAAGCTGGACATCATGATCCGCCTGGCCTCTCAG
GCCAACATCGCCCAGCATCTGTGAGCGGGTCACCCCCAGGCTCTCCCATGCCAACTCCGCTGTGGTGCTCTCTGCTGTGAAGGTGCTGAT
GAAGTTCATGGAGATGTTGTCTAAGGACTTGGACTACTACGGCACACTGCTCAAGAAGCTGGCCCCACCCCTGGTCACACTGCTGTCAGC
CGAGCCAGAGCTGCAGTATGTGGCCCTGCGCAACATCAATCTCATCGTGCAGAAAAGGTGGTGGCCAATGCAGTGGCAGCGCTCTCAGAA
ATTGCCGAGTCTCACCCCAGCAGCAACCTGCTCGATCTGAACCCACAGTCCATCAACAAGCTGCTGACAGCCCTCAATGAGTGCACCGAG

>56101_56101_3_MVP-AP1B1_MVP_chr16_29859133_ENST00000357402_AP1B1_chr22_29754725_ENST00000357586_length(amino acids)=882AA_BP=
MGLGVTMATEEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCTVANPVSRDAQGLVLFDVTGQVRLR
HADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTALHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEIIQATIIRQNQAL
RLRARKECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRDFRGVSRRTGEEWLVTVQDTEAHVPDVH
EEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKRVVKGEKSFFLQPGEQLEQGIQDVYVLSEQQGLLLRALQPLEEGEDEEKVSHQAG
DHWLIRGPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLADRGEKDTAK
SLQPLAPRNKTRVVSYRVPHNAAVQVYDYREKRARVVFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADH
ARLQLQLAYNWHFEVNDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGFETSEAKGPDGMALPRPRD
QAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSM
AVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAIGP

--------------------------------------------------------------
>56101_56101_4_MVP-AP1B1_MVP_chr16_29859133_ENST00000357402_AP1B1_chr22_29754725_ENST00000402502_length(transcript)=5203nt_BP=2814nt
ACCCCTGGGCTTGGCCTGCCTTGCCCTGCCGGGAAGTGATCCCCAAGGCAGGGTGAGAGTTCCCCATCTGAGGCGTTTGTTGCAGCTACC
TGCACTTCTAGATTCATCTTCTTGTGAGCCCTGGGCTTAGGAGTCACCATGGCAACTGAAGAGTTCATCATCCGCATCCCCCCATACCAC
TATATCCATGTGCTGGACCAGAACAGCAACGTGTCCCGTGTGGAGGTCGGGCCAAAGACCTACATCCGGCAGGACAATGAGAGGGTACTG
TTTGCCCCCATGCGCATGGTGACCGTCCCCCCACGTCACTACTGCACAGTGGCCAACCCTGTGTCTCGGGATGCCCAGGGCTTGGTGCTG
TTTGATGTCACAGGGCAAGTTCGGCTTCGCCACGCTGACCTCGAGATCCGGCTGGCCCAGGACCCCTTCCCCCTGTACCCAGGGGAGGTG
CTGGAAAAGGACATCACACCCCTGCAGGTGGTTCTGCCCAACACTGCCCTCCATCTAAAGGCGCTGCTTGATTTTGAGGATAAAGATGGA
GACAAGGTGGTGGCAGGAGATGAGTGGCTTTTCGAGGGACCTGGCACGTACATCCCCCGGAAGGAAGTGGAGGTCGTGGAGATCATTCAG
GCCACCATCATCAGGCAGAACCAGGCTCTGCGGCTCAGGGCCCGCAAGGAGTGCTGGGACCGGGACGGCAAGGAGAGGGTGACAGGGGAA
GAATGGCTGGTCACCACAGTAGGGGCGTACCTCCCAGCGGTGTTTGAGGAGGTTCTGGATTTGGTGGACGCCGTCATCCTTACGGAAAAG
ACAGCCCTGCACCTCCGGGCTCGGCGGAACTTCCGGGACTTCAGGGGAGTGTCCCGCCGCACTGGGGAGGAGTGGCTGGTAACAGTGCAG
GACACAGAGGCCCACGTGCCAGATGTCCACGAGGAGGTGCTGGGGGTTGTGCCCATCACCACCCTGGGCCCCCACAACTACTGCGTGATT
CTCGACCCTGTCGGACCGGATGGCAAGAATCAGCTGGGGCAGAAGCGCGTGGTCAAGGGAGAGAAGTCTTTTTTCCTCCAGCCAGGAGAG
CAGCTGGAACAAGGCATCCAGGATGTGTATGTGCTGTCGGAGCAGCAGGGGCTGCTGCTGAGGGCCCTGCAGCCCCTGGAGGAGGGGGAG
GATGAGGAGAAGGTCTCACACCAGGCTGGGGACCACTGGCTCATCCGCGGACCCCTGGAGTATGTGCCATCTGCCAAAGTGGAGGTGGTG
GAGGAGCGCCAGGCCATCCCTCTAGACGAGAACGAGGGCATCTATGTGCAGGATGTCAAGACCGGAAAGGTGCGCGCTGTGATTGGAAGC
ACCTACATGCTGACCCAGGACGAAGTCCTGTGGGAGAAAGAGCTGCCTCCCGGGGTGGAGGAGCTGCTGAACAAGGGGCAGGACCCTCTG
GCAGACAGGGGTGAGAAGGACACAGCTAAGAGCCTCCAGCCCTTGGCGCCCCGGAACAAGACCCGTGTGGTCAGCTACCGCGTGCCCCAC
AACGCTGCGGTGCAGGTGTACGACTACCGAGAGAAGCGAGCCCGCGTGGTCTTCGGGCCTGAGCTGGTGTCGCTGGGTCCTGAGGAGCAG
TTCACAGTGTTGTCCCTCTCAGCTGGGCGGCCCAAGCGTCCCCATGCCCGCCGTGCGCTCTGCCTGCTGCTGGGGCCTGACTTCTTCACA
GACGTCATCACCATCGAAACGGCGGATCATGCCAGGCTGCAACTGCAGCTGGCCTACAACTGGCACTTTGAGGTGAATGACCGGAAGGAC
CCCCAAGAGACGGCCAAGCTCTTTTCAGTGCCAGACTTTGTAGGTGATGCCTGCAAAGCCATCGCATCCCGGGTGCGGGGGGCCGTGGCC
TCTGTCACTTTCGATGACTTCCATAAGAACTCAGCCCGCATCATTCGCACTGCTGTCTTTGGCTTTGAGACCTCGGAAGCGAAGGGCCCC
GATGGCATGGCCCTGCCCAGGCCCCGGGACCAGGCTGTCTTCCCCCAAAACGGGCTGGTGGTCAGCAGTGTGGACGTGCAGTCAGTGGAG
CCTGTGGATCAGAGGACCCGGGACGCCCTGCAACGCAGCGTCCAGCTGGCCATCGAGATCACCACCAACTCCCAGGAAGCGGCGGCCAAG
CATGAGGCTCAGAGACTGGAGCAGGAAGCCCGCGGCCGGCTTGAGCGGCAGAAGATCCTGGACCAGTCAGAAGCCGAGAAAGCTCGCAAG
GAACTTTTGGAGCTGGAGGCTCTGAGCATGGCCGTGGAGAGCACCGGGACTGCCAAGGCGGAGGCCGAGTCCCGTGCGGAGGCAGCCCGG
ATTGAGGGAGAAGGGTCCGTGCTGCAGGCCAAGCTAAAAGCACAGGCCTTGGCCATTGAAACGGAGGCTGAGCTCCAGAGGGTCCAGAAG
GTCCGAGAGCTGGAACTGGTCTATGCCCGGGCCCAGCTGGAGCTGGAGGTGAGCAAGGCTCAGCAGCTGGCTGAGGTGGAGGTGAAGAAG
TTCAAGCAGATGACAGAGGCCATAGGCCCCAGCACCATCAGGGACCTTGCTGTGGCTGGGCCTGAGATGCAGTCCACTCCCATCAACCTC
TTCAACACAGCCTTTGGGCTGCTGGGGATGGGGCCCGAGGGTCAGCCCCTGGGCAGAAGGGTGGCCAGTGGGCCCAGCCCTGGGGAGGGG
ATATCCCCCCAGTCTGCTCAGGCCCCTCAAGCTCCTGGAGACAACCACGTGGTGCCTGTACTGCGCTAACTCCTGATTAATACAATGGAA
GTTTCTGGGCATTTACAATTTCAACTGTCCCTGAAGTGTCGAGCACCAGAGGTGTCCCAGCACGTGTACCAGGCCTACGAGACCATCCTC
AAGAACTGAGACCCCGGCCAGCGCCCACCCCAGCCTTCTGCCCGCCCCATCGAGGAGGCCCCTCGGGGGCAGCACATCTTCCTCCTCGCA
GGAGGCTGCGAGCAGCAAGCTGCAGAGCAGCAACATCTTCACTGTCGCCAAGAGGAACGTGGAGGGCCAGGACATGCTCTACCAGTCCCT
GAAGCTGACCAACGGCATCTGGGTGCTGGCGGAGCTGCGGATCCAGCCGGGCAACCCCAGCTGCACGACCGGCAGATGTTCCTGGCCACA
TGGAAGGATATTCCCAATGAGAATGAGGCCCAGTTCCAGATCAGAGACTGCCCCCTCAATGCAGGTGGCCGTGAAGAACAACATCGATGT
CTTCTACTTCAGCACCTTGTACCCACTGCACATCCTCTTTGTGGAGGACGGGAAGATGGCTTTGGCCTGGCCCCCGCCACCCCCCTCCAG
GTCCACGCGCCACTCAGCCCCAACCAGACAGTGGAGATCTCCCTGCCTCTCAGCACGGTGGGCTCGGTCATGAAGATGGAGCCTCTGAAC
AACCTCCAGGTCTGGCTCCCAGCCATGAAGGCTAAGGGGCTGGAGATCTCAGGCACCTTCACCCGCCAGGTGGGCTCCATCTCCATGGAC
CTGCAGCTGACCAACAAGGCCTTGCAGGTCATGACCGACTTTGCCATCCAGTTCAACCGCAACAGATTGGGGGCACCAACTTCGTGGCAC
CTCCAACAGCAGCAGTACCAGCCAATCTTGGAGCACCCATCGGCAGTGGCCTGAGTGACCTCTTTGACCTGACCAGTGGCGTGGGCACCC
TGTCAGGATCATATGTGGCCCCCAAAGCAGAGTGAGAGCGCAGAGAGCCCTGAGACAGCCCCTACTGGAGCACCTCCTGGGGAGCAGCCA
GATGTCATCCCCGCCCAGGGCGACCTGCTGGGTGACCTCCTCAACCTGGACCTCGGCCCCCCAGTGAGCGGCCCACCCCTGGCCACCTCC
TCGGTGCAGATGGGAGCTGTGGACCTTCTTGGCGGTGGCCTTGACAGCCTGGACTCAGATAACCCAGACCTGCGGGACCGTGGCTACATC
TACTGGCGCCTGCTGTCCACGGACCCGGTGGCAGCCAAGGAGGTGGTGTTGGCTGAGAAGCCACTCATCTCTGAAGAGACGGACCTCATC
GAGCCCACACTGTTAGACGAGCTTATCTGCTACATCGGCACGCTGGCTTCCGTCTACCATAAGCCTCCCAGTGCCTTTGTGGAGGGGGGC
CGGGGCGTCGTGCACAAGAGCCTGCCACCTCGCACGGCCTCGTCCAGCTGCAGCTGCTGACAGCCATTGTGAAACTCTTTCTAAAGAAGC
CAACAGAGACCCAGGAGCTGGTGCAGCAGGTCCTCAGTTTGGCCACTCAGGTATGAGAGTGTGATTGCCACACTGTGTGAGAATCTGGAC
TCCCTGGATGAGCCTGAGGCCCGGGCTGCCATGATCTGGATTGTGGGCGAGTACGCGGAACGGATCGACAACGCAGATGAGCTGCTGGAG
AGCTTCCTCGAGGGCTTCCATGACGAGAGCACACAGCAATCTGCGGAGCGCTGTGTGAGCACGCTGCTCGACCTCATCCAGACCAAGGTC
AACTATGTGGTCCAGGAGGCCATCGTGGTCATCAAGGACATCTTCCGCAAGTACCCCAACAAGTGTTGGCAGAGCTGAAAGAGTACGCAA
CAGAAGTGGATGTGGACTTTGTACGGAAGGCTGTGCGTGCTATTGGCCGCTGCGCCATCAAGGTGGAGGCCTGAGATCCTGAAGCATGAG
ATGAAGGTGTTCTTCGTGAAGTACAACGACCCTATCTACGTGAAGCTGGAGAAGCTGGACATCATGATCCGCCTGGCCTCTCAGGCCAAC
ATCGCCCAGCATCTGTGAGCGGGTCACCCCCAGGCTCTCCCATGCCAACTCCGCTGTGGTGCTCTCTGCTGTGAAGGTGCTGATGAAGTT
CATGGAGATGTTGTCTAAGGACTTGGACTACTACGGCACACTGCTCAAGAAGCTGGCCCCACCCCTGGTCACACTGCTGTCAGCCGAGCC
AGAGCTGCAGTATGTGGCCCTGCGCAACATCAATCTCATCGTGCAGAAAAGGTGGTGGCCAATGCAGTGGCAGCGCTCTCAGAAATTGCC
GAGTCTCACCCCAGCAGCAACCTGCTCGATCTGAACCCACAGTCCATCAACAAGCTGCTGACAGCCCTCAATGAGTGCACCGAGTGGGGC

>56101_56101_4_MVP-AP1B1_MVP_chr16_29859133_ENST00000357402_AP1B1_chr22_29754725_ENST00000402502_length(amino acids)=882AA_BP=
MGLGVTMATEEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCTVANPVSRDAQGLVLFDVTGQVRLR
HADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTALHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEIIQATIIRQNQAL
RLRARKECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRDFRGVSRRTGEEWLVTVQDTEAHVPDVH
EEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKRVVKGEKSFFLQPGEQLEQGIQDVYVLSEQQGLLLRALQPLEEGEDEEKVSHQAG
DHWLIRGPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLADRGEKDTAK
SLQPLAPRNKTRVVSYRVPHNAAVQVYDYREKRARVVFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADH
ARLQLQLAYNWHFEVNDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGFETSEAKGPDGMALPRPRD
QAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSM
AVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAIGP

--------------------------------------------------------------
>56101_56101_5_MVP-AP1B1_MVP_chr16_29859133_ENST00000357402_AP1B1_chr22_29754725_ENST00000405198_length(transcript)=6106nt_BP=2814nt
ACCCCTGGGCTTGGCCTGCCTTGCCCTGCCGGGAAGTGATCCCCAAGGCAGGGTGAGAGTTCCCCATCTGAGGCGTTTGTTGCAGCTACC
TGCACTTCTAGATTCATCTTCTTGTGAGCCCTGGGCTTAGGAGTCACCATGGCAACTGAAGAGTTCATCATCCGCATCCCCCCATACCAC
TATATCCATGTGCTGGACCAGAACAGCAACGTGTCCCGTGTGGAGGTCGGGCCAAAGACCTACATCCGGCAGGACAATGAGAGGGTACTG
TTTGCCCCCATGCGCATGGTGACCGTCCCCCCACGTCACTACTGCACAGTGGCCAACCCTGTGTCTCGGGATGCCCAGGGCTTGGTGCTG
TTTGATGTCACAGGGCAAGTTCGGCTTCGCCACGCTGACCTCGAGATCCGGCTGGCCCAGGACCCCTTCCCCCTGTACCCAGGGGAGGTG
CTGGAAAAGGACATCACACCCCTGCAGGTGGTTCTGCCCAACACTGCCCTCCATCTAAAGGCGCTGCTTGATTTTGAGGATAAAGATGGA
GACAAGGTGGTGGCAGGAGATGAGTGGCTTTTCGAGGGACCTGGCACGTACATCCCCCGGAAGGAAGTGGAGGTCGTGGAGATCATTCAG
GCCACCATCATCAGGCAGAACCAGGCTCTGCGGCTCAGGGCCCGCAAGGAGTGCTGGGACCGGGACGGCAAGGAGAGGGTGACAGGGGAA
GAATGGCTGGTCACCACAGTAGGGGCGTACCTCCCAGCGGTGTTTGAGGAGGTTCTGGATTTGGTGGACGCCGTCATCCTTACGGAAAAG
ACAGCCCTGCACCTCCGGGCTCGGCGGAACTTCCGGGACTTCAGGGGAGTGTCCCGCCGCACTGGGGAGGAGTGGCTGGTAACAGTGCAG
GACACAGAGGCCCACGTGCCAGATGTCCACGAGGAGGTGCTGGGGGTTGTGCCCATCACCACCCTGGGCCCCCACAACTACTGCGTGATT
CTCGACCCTGTCGGACCGGATGGCAAGAATCAGCTGGGGCAGAAGCGCGTGGTCAAGGGAGAGAAGTCTTTTTTCCTCCAGCCAGGAGAG
CAGCTGGAACAAGGCATCCAGGATGTGTATGTGCTGTCGGAGCAGCAGGGGCTGCTGCTGAGGGCCCTGCAGCCCCTGGAGGAGGGGGAG
GATGAGGAGAAGGTCTCACACCAGGCTGGGGACCACTGGCTCATCCGCGGACCCCTGGAGTATGTGCCATCTGCCAAAGTGGAGGTGGTG
GAGGAGCGCCAGGCCATCCCTCTAGACGAGAACGAGGGCATCTATGTGCAGGATGTCAAGACCGGAAAGGTGCGCGCTGTGATTGGAAGC
ACCTACATGCTGACCCAGGACGAAGTCCTGTGGGAGAAAGAGCTGCCTCCCGGGGTGGAGGAGCTGCTGAACAAGGGGCAGGACCCTCTG
GCAGACAGGGGTGAGAAGGACACAGCTAAGAGCCTCCAGCCCTTGGCGCCCCGGAACAAGACCCGTGTGGTCAGCTACCGCGTGCCCCAC
AACGCTGCGGTGCAGGTGTACGACTACCGAGAGAAGCGAGCCCGCGTGGTCTTCGGGCCTGAGCTGGTGTCGCTGGGTCCTGAGGAGCAG
TTCACAGTGTTGTCCCTCTCAGCTGGGCGGCCCAAGCGTCCCCATGCCCGCCGTGCGCTCTGCCTGCTGCTGGGGCCTGACTTCTTCACA
GACGTCATCACCATCGAAACGGCGGATCATGCCAGGCTGCAACTGCAGCTGGCCTACAACTGGCACTTTGAGGTGAATGACCGGAAGGAC
CCCCAAGAGACGGCCAAGCTCTTTTCAGTGCCAGACTTTGTAGGTGATGCCTGCAAAGCCATCGCATCCCGGGTGCGGGGGGCCGTGGCC
TCTGTCACTTTCGATGACTTCCATAAGAACTCAGCCCGCATCATTCGCACTGCTGTCTTTGGCTTTGAGACCTCGGAAGCGAAGGGCCCC
GATGGCATGGCCCTGCCCAGGCCCCGGGACCAGGCTGTCTTCCCCCAAAACGGGCTGGTGGTCAGCAGTGTGGACGTGCAGTCAGTGGAG
CCTGTGGATCAGAGGACCCGGGACGCCCTGCAACGCAGCGTCCAGCTGGCCATCGAGATCACCACCAACTCCCAGGAAGCGGCGGCCAAG
CATGAGGCTCAGAGACTGGAGCAGGAAGCCCGCGGCCGGCTTGAGCGGCAGAAGATCCTGGACCAGTCAGAAGCCGAGAAAGCTCGCAAG
GAACTTTTGGAGCTGGAGGCTCTGAGCATGGCCGTGGAGAGCACCGGGACTGCCAAGGCGGAGGCCGAGTCCCGTGCGGAGGCAGCCCGG
ATTGAGGGAGAAGGGTCCGTGCTGCAGGCCAAGCTAAAAGCACAGGCCTTGGCCATTGAAACGGAGGCTGAGCTCCAGAGGGTCCAGAAG
GTCCGAGAGCTGGAACTGGTCTATGCCCGGGCCCAGCTGGAGCTGGAGGTGAGCAAGGCTCAGCAGCTGGCTGAGGTGGAGGTGAAGAAG
TTCAAGCAGATGACAGAGGCCATAGGCCCCAGCACCATCAGGGACCTTGCTGTGGCTGGGCCTGAGATGCAGTCCACTCCCATCAACCTC
TTCAACACAGCCTTTGGGCTGCTGGGGATGGGGCCCGAGGGTCAGCCCCTGGGCAGAAGGGTGGCCAGTGGGCCCAGCCCTGGGGAGGGG
ATATCCCCCCAGTCTGCTCAGGCCCCTCAAGCTCCTGGAGACAACCACGTGGTGCCTGTACTGCGCTAACTCCTGATTAATACAATGGAA
GTTTCTGGGCATTTACAATTTCAACTGTCCCTGAAGTGTCGAGCACCAGAGGTGTCCCAGCACGTGTACCAGGCCTACGAGACCATCCTC
AAGAACTGAGACCCCGGCCAGCGCCCACCCCAGCCTTCTGCCCGCCCCATCGAGGAGGCCCCTCGGGGGCAGCACATCTTCCTCCTCGCA
GGAGGGACCAGGCGGGGCTCCAGGCCACTCAGTGGGCTCCCTGGTCCTGATGGCAGAACCCACCCGATCCCTGGGGTAGGGCACCACCCC
CTCCTGGGGTGAGAGCGCAGTGCACTCCCGTGCTCTGGGACACCCCTGCTCCTGTGGCTGTGATGTGGGGTTAAGTGAGGTGGGGACCAA
AGGAAACAGAGCCAGAGCAGCCACAGAAGCTGTGCCTGAAGGGTGAGTGTGGAGCTTGCCCCTCCGGCTCACAGCCCCGGCAGCCCCTGG
CTCCTTGGTCTCTCCGGTTGGTGTTAAAGGGCCCTCCACTGCCACCTCTCATGGGATGGACCCTGCCAACCTGGCCTGGGTGTGCAGGGA
GGGGTTCCCCTTGGTACCAGGAGAGCTGCTCACTTAGGGCCTGGGGCTCAAGGAGCTGTAGGTGCCGGCAGAGGGGCAGAGCTAGGCTGG
GAGGAGCCCAGGGCCTGCACCACCCACTTGCAACCACCAGGCTGGTGCCCTGCAGCTGTGCCAGTTGGGCCACAGCCTCCCGAGTGCTGA
CCCACATGGTCAAGACCAGGCAGAAGCTCCCAGAGCCCCTGTCTCGGGCTCCCCACCGACTGGCAGCTGCACTATCCCCAACTCCCCACT
TCTGCCCCAAGGGTGGTCACTGCCTGTGATACATTCCTCAGTGTCGCCTCTGAGCCCAGGCCTCCTGCCACAAAGACTGGGCCGAGAGAT
GGGGCTGGGTAAGCGGGTGCGCCTCCTGTTTGGGTTTCTTCGGGGTTTCTCTGTAGTGTCTGCTGCCCTCCTCCTGGCCTCCCAGGTTTC
AGTTGTGTCTGACAGAGCATTAGGTTTTCCTGTTACTGCTGTGTAATAATAAAGAAAGATTCGGCGACTTAGAGAGGCTGCGAGCAGCAA
GCTGCAGAGCAGCAACATCTTCACTGTCGCCAAGAGGAACGTGGAGGGCCAGGACATGCTCTACCAGTCCCTGAAGCTGACCAACGGCAT
CTGGGTGCTGGCGGAGCTGCGGATCCAGCCGGGCAACCCCAGCTGCACGACCGGCAGATGTTCCTGGCCACATGGAAGGATATTCCCAAT
GAGAATGAGGCCCAGTTCCAGATCAGAGACTGCCCCCTCAATGCAGGTGGCCGTGAAGAACAACATCGATGTCTTCTACTTCAGCACCTT
GTACCCACTGCACATCCTCTTTGTGGAGGACGGGAAGATGGCTTTGGCCTGGCCCCCGCCACCCCCCTCCAGGTCCACGCGCCACTCAGC
CCCAACCAGACAGTGGAGATCTCCCTGCCTCTCAGCACGGTGGGCTCGGTCATGAAGATGGAGCCTCTGAACAACCTCCAGGTCTGGCTC
CCAGCCATGAAGGCTAAGGGGCTGGAGATCTCAGGCACCTTCACCCGCCAGGTGGGCTCCATCTCCATGGACCTGCAGCTGACCAACAAG
GCCTTGCAGGTCATGACCGACTTTGCCATCCAGTTCAACCGCAACAGATTGGGGGCACCAACTTCGTGGCACCTCCAACAGCAGCAGTAC
CAGCCAATCTTGGAGCACCCATCGGCAGTGGCCTGAGTGACCTCTTTGACCTGACCAGTGGCGTGGGCACCCTGTCAGGATCATATGTGG
CCCCCAAAGCAATGGGGGATGAGCCTGAAGGGGAGTGAGAGCGCAGAGAGCCCTGAGACAGCCCCTACTGGAGCACCTCCTGGGGAGCAG
CCAGATGTCATCCCCGCCCAGGGCGACCTGCTGGGTGACCTCCTCAACCTGGACCTCGGCCCCCCAGTGAGCGGCCCACCCCTGGCCACC
TCCTCGGTGCAGATGGGAGCTGTGGACCTTCTTGGCGGTGGCCTTGACAGCCTGGACTCAGATAACCCAGACCTGCGGGACCGTGGCTAC
ATCTACTGGCGCCTGCTGTCCACGGACCCGGTGGCAGCCAAGGAGGTGGTGTTGGCTGAGAAGCCACTCATCTCTGAAGAGACGGACCTC
ATCGAGCCCACACTGTTAGACGAGCTTATCTGCTACATCGGCACGCTGGCTTCCGTCTACCATAAGCCTCCCAGTGCCTTTGTGGAGGGG
GGCCGGGGCGTCGTGCACAAGAGCCTGCCACCTCGCACGGCCTCGTCCAGCTGCAGCTGCTGACAGCCATTGTGAAACTCTTTCTAAAGA
AGCCAACAGAGACCCAGGAGCTGGTGCAGCAGGTCCTCAGTTTGGCCACTCAGGTATGAGAGTGTGATTGCCACACTGTGTGAGAATCTG
GACTCCCTGGATGAGCCTGAGGCCCGGGCTGCCATGATCTGGATTGTGGGCGAGTACGCGGAACGGATCGACAACGCAGATGAGCTGCTG
GAGAGCTTCCTCGAGGGCTTCCATGACGAGAGCACACAGCAATCTGCGGAGCGCTGTGTGAGCACGCTGCTCGACCTCATCCAGACCAAG
GTCAACTATGTGGTCCAGGAGGCCATCGTGGTCATCAAGGACATCTTCCGCAAGTACCCCAACAAGTGTTGGCAGAGCTGAAAGAGTACG
CAACAGAAGTGGATGTGGACTTTGTACGGAAGGCTGTGCGTGCTATTGGCCGCTGCGCCATCAAGGTGGAGGCCTGAGATCCTGAAGCAT
GAGATGAAGGTGTTCTTCGTGAAGTACAACGACCCTATCTACGTGAAGCTGGAGAAGCTGGACATCATGATCCGCCTGGCCTCTCAGGCC
AACATCGCCCAGCATCTGTGAGCGGGTCACCCCCAGGCTCTCCCATGCCAACTCCGCTGTGGTGCTCTCTGCTGTGAAGGTGCTGATGAA
GTTCATGGAGATGTTGTCTAAGGACTTGGACTACTACGGCACACTGCTCAAGAAGCTGGCCCCACCCCTGGTCACACTGCTGTCAGCCGA
GCCAGAGCTGCAGTATGTGGCCCTGCGCAACATCAATCTCATCGTGCAGAAAAGGTGGTGGCCAATGCAGTGGCAGCGCTCTCAGAAATT
GCCGAGTCTCACCCCAGCAGCAACCTGCTCGATCTGAACCCACAGTCCATCAACAAGCTGCTGACAGCCCTCAATGAGTGCACCGAGTGG

>56101_56101_5_MVP-AP1B1_MVP_chr16_29859133_ENST00000357402_AP1B1_chr22_29754725_ENST00000405198_length(amino acids)=882AA_BP=
MGLGVTMATEEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCTVANPVSRDAQGLVLFDVTGQVRLR
HADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTALHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEIIQATIIRQNQAL
RLRARKECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRDFRGVSRRTGEEWLVTVQDTEAHVPDVH
EEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKRVVKGEKSFFLQPGEQLEQGIQDVYVLSEQQGLLLRALQPLEEGEDEEKVSHQAG
DHWLIRGPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLADRGEKDTAK
SLQPLAPRNKTRVVSYRVPHNAAVQVYDYREKRARVVFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADH
ARLQLQLAYNWHFEVNDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGFETSEAKGPDGMALPRPRD
QAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSM
AVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAIGP

--------------------------------------------------------------
>56101_56101_6_MVP-AP1B1_MVP_chr16_29859133_ENST00000357402_AP1B1_chr22_29754725_ENST00000415447_length(transcript)=5120nt_BP=2814nt
ACCCCTGGGCTTGGCCTGCCTTGCCCTGCCGGGAAGTGATCCCCAAGGCAGGGTGAGAGTTCCCCATCTGAGGCGTTTGTTGCAGCTACC
TGCACTTCTAGATTCATCTTCTTGTGAGCCCTGGGCTTAGGAGTCACCATGGCAACTGAAGAGTTCATCATCCGCATCCCCCCATACCAC
TATATCCATGTGCTGGACCAGAACAGCAACGTGTCCCGTGTGGAGGTCGGGCCAAAGACCTACATCCGGCAGGACAATGAGAGGGTACTG
TTTGCCCCCATGCGCATGGTGACCGTCCCCCCACGTCACTACTGCACAGTGGCCAACCCTGTGTCTCGGGATGCCCAGGGCTTGGTGCTG
TTTGATGTCACAGGGCAAGTTCGGCTTCGCCACGCTGACCTCGAGATCCGGCTGGCCCAGGACCCCTTCCCCCTGTACCCAGGGGAGGTG
CTGGAAAAGGACATCACACCCCTGCAGGTGGTTCTGCCCAACACTGCCCTCCATCTAAAGGCGCTGCTTGATTTTGAGGATAAAGATGGA
GACAAGGTGGTGGCAGGAGATGAGTGGCTTTTCGAGGGACCTGGCACGTACATCCCCCGGAAGGAAGTGGAGGTCGTGGAGATCATTCAG
GCCACCATCATCAGGCAGAACCAGGCTCTGCGGCTCAGGGCCCGCAAGGAGTGCTGGGACCGGGACGGCAAGGAGAGGGTGACAGGGGAA
GAATGGCTGGTCACCACAGTAGGGGCGTACCTCCCAGCGGTGTTTGAGGAGGTTCTGGATTTGGTGGACGCCGTCATCCTTACGGAAAAG
ACAGCCCTGCACCTCCGGGCTCGGCGGAACTTCCGGGACTTCAGGGGAGTGTCCCGCCGCACTGGGGAGGAGTGGCTGGTAACAGTGCAG
GACACAGAGGCCCACGTGCCAGATGTCCACGAGGAGGTGCTGGGGGTTGTGCCCATCACCACCCTGGGCCCCCACAACTACTGCGTGATT
CTCGACCCTGTCGGACCGGATGGCAAGAATCAGCTGGGGCAGAAGCGCGTGGTCAAGGGAGAGAAGTCTTTTTTCCTCCAGCCAGGAGAG
CAGCTGGAACAAGGCATCCAGGATGTGTATGTGCTGTCGGAGCAGCAGGGGCTGCTGCTGAGGGCCCTGCAGCCCCTGGAGGAGGGGGAG
GATGAGGAGAAGGTCTCACACCAGGCTGGGGACCACTGGCTCATCCGCGGACCCCTGGAGTATGTGCCATCTGCCAAAGTGGAGGTGGTG
GAGGAGCGCCAGGCCATCCCTCTAGACGAGAACGAGGGCATCTATGTGCAGGATGTCAAGACCGGAAAGGTGCGCGCTGTGATTGGAAGC
ACCTACATGCTGACCCAGGACGAAGTCCTGTGGGAGAAAGAGCTGCCTCCCGGGGTGGAGGAGCTGCTGAACAAGGGGCAGGACCCTCTG
GCAGACAGGGGTGAGAAGGACACAGCTAAGAGCCTCCAGCCCTTGGCGCCCCGGAACAAGACCCGTGTGGTCAGCTACCGCGTGCCCCAC
AACGCTGCGGTGCAGGTGTACGACTACCGAGAGAAGCGAGCCCGCGTGGTCTTCGGGCCTGAGCTGGTGTCGCTGGGTCCTGAGGAGCAG
TTCACAGTGTTGTCCCTCTCAGCTGGGCGGCCCAAGCGTCCCCATGCCCGCCGTGCGCTCTGCCTGCTGCTGGGGCCTGACTTCTTCACA
GACGTCATCACCATCGAAACGGCGGATCATGCCAGGCTGCAACTGCAGCTGGCCTACAACTGGCACTTTGAGGTGAATGACCGGAAGGAC
CCCCAAGAGACGGCCAAGCTCTTTTCAGTGCCAGACTTTGTAGGTGATGCCTGCAAAGCCATCGCATCCCGGGTGCGGGGGGCCGTGGCC
TCTGTCACTTTCGATGACTTCCATAAGAACTCAGCCCGCATCATTCGCACTGCTGTCTTTGGCTTTGAGACCTCGGAAGCGAAGGGCCCC
GATGGCATGGCCCTGCCCAGGCCCCGGGACCAGGCTGTCTTCCCCCAAAACGGGCTGGTGGTCAGCAGTGTGGACGTGCAGTCAGTGGAG
CCTGTGGATCAGAGGACCCGGGACGCCCTGCAACGCAGCGTCCAGCTGGCCATCGAGATCACCACCAACTCCCAGGAAGCGGCGGCCAAG
CATGAGGCTCAGAGACTGGAGCAGGAAGCCCGCGGCCGGCTTGAGCGGCAGAAGATCCTGGACCAGTCAGAAGCCGAGAAAGCTCGCAAG
GAACTTTTGGAGCTGGAGGCTCTGAGCATGGCCGTGGAGAGCACCGGGACTGCCAAGGCGGAGGCCGAGTCCCGTGCGGAGGCAGCCCGG
ATTGAGGGAGAAGGGTCCGTGCTGCAGGCCAAGCTAAAAGCACAGGCCTTGGCCATTGAAACGGAGGCTGAGCTCCAGAGGGTCCAGAAG
GTCCGAGAGCTGGAACTGGTCTATGCCCGGGCCCAGCTGGAGCTGGAGGTGAGCAAGGCTCAGCAGCTGGCTGAGGTGGAGGTGAAGAAG
TTCAAGCAGATGACAGAGGCCATAGGCCCCAGCACCATCAGGGACCTTGCTGTGGCTGGGCCTGAGATGCAGTCCACTCCCATCAACCTC
TTCAACACAGCCTTTGGGCTGCTGGGGATGGGGCCCGAGGGTCAGCCCCTGGGCAGAAGGGTGGCCAGTGGGCCCAGCCCTGGGGAGGGG
ATATCCCCCCAGTCTGCTCAGGCCCCTCAAGCTCCTGGAGACAACCACGTGGTGCCTGTACTGCGCTAACTCCTGATTAATACAATGGAA
GTTTCTGGGCATTTACAATTTCAACTGTCCCTGAAGTGTCGAGCACCAGAGGTGTCCCAGCACGTGTACCAGGCCTACGAGACCATCCTC
AAGAACTGAAGGCTGCGAGCAGCAAGCTGCAGAGCAGCAACATCTTCACTGTCGCCAAGAGGAACGTGGAGGGCCAGGACATGCTCTACC
AGTCCCTGAAGCTGACCAACGGCATCTGGGTGCTGGCGGAGCTGCGGATCCAGCCGGGCAACCCCAGCTGCACGACCGGCAGATGTTCCT
GGCCACATGGAAGGATATTCCCAATGAGAATGAGGCCCAGTTCCAGATCAGAGACTGCCCCCTCAATGCAGGTGGCCGTGAAGAACAACA
TCGATGTCTTCTACTTCAGCACCTTGTACCCACTGCACATCCTCTTTGTGGAGGACGGGAAGATGGCTTTGGCCTGGCCCCCGCCACCCC
CCTCCAGGTCCACGCGCCACTCAGCCCCAACCAGACAGTGGAGATCTCCCTGCCTCTCAGCACGGTGGGCTCGGTCATGAAGATGGAGCC
TCTGAACAACCTCCAGGTCTGGCTCCCAGCCATGAAGGCTAAGGGGCTGGAGATCTCAGGCACCTTCACCCGCCAGGTGGGCTCCATCTC
CATGGACCTGCAGCTGACCAACAAGGCCTTGCAGGTCATGACCGACTTTGCCATCCAGTTCAACCGCAACAGATTGGGGGCACCAACTTC
GTGGCACCTCCAACAGCAGCAGTACCAGCCAATCTTGGAGCACCCATCGGCAGTGGCCTGAGTGACCTCTTTGACCTGACCAGTGGCGTG
GGCACCCTGTCAGGATCATATGTGGCCCCCAAAGCAGAGTGAGAGCGCAGAGAGCCCTGAGACAGCCCCTACTGGAGCACCTCCTGGGGA
GCAGCCAGATGTCATCCCCGCCCAGGGCGACCTGCTGGGTGACCTCCTCAACCTGGACCTCGGCCCCCCAGTGAGCGGCCCACCCCTGGC
CACCTCCTCGGTGCAGATGGGAGCTGTGGACCTTCTTGGCGGTGGCCTTGACAGCCTGGACTCAGATAACCCAGACCTGCGGGACCGTGG
CTACATCTACTGGCGCCTGCTGTCCACGGACCCGGTGGCAGCCAAGGAGGTGGTGTTGGCTGAGAAGCCACTCATCTCTGAAGAGACGGA
CCTCATCGAGCCCACACTGTTAGACGAGCTTATCTGCTACATCGGCACGCTGGCTTCCGTCTACCATAAGCCTCCCAGTGCCTTTGTGGA
GGGGGGCCGGGGCGTCGTGCACAAGAGCCTGCCACCTCGCACGGCCTCGTCCAGCTGCAGCTGCTGACAGCCATTGTGAAACTCTTTCTA
AAGAAGCCAACAGAGACCCAGGAGCTGGTGCAGCAGGTCCTCAGTTTGGCCACTCAGGTATGAGAGTGTGATTGCCACACTGTGTGAGAA
TCTGGACTCCCTGGATGAGCCTGAGGCCCGGGCTGCCATGATCTGGATTGTGGGCGAGTACGCGGAACGGATCGACAACGCAGATGAGCT
GCTGGAGAGCTTCCTCGAGGGCTTCCATGACGAGAGCACACAGCAATCTGCGGAGCGCTGTGTGAGCACGCTGCTCGACCTCATCCAGAC
CAAGGTCAACTATGTGGTCCAGGAGGCCATCGTGGTCATCAAGGACATCTTCCGCAAGTACCCCAACAAGTGTTGGCAGAGCTGAAAGAG
TACGCAACAGAAGTGGATGTGGACTTTGTACGGAAGGCTGTGCGTGCTATTGGCCGCTGCGCCATCAAGGTGGAGGCCTGAGATCCTGAA
GCATGAGATGAAGGTGTTCTTCGTGAAGTACAACGACCCTATCTACGTGAAGCTGGAGAAGCTGGACATCATGATCCGCCTGGCCTCTCA
GGCCAACATCGCCCAGCATCTGTGAGCGGGTCACCCCCAGGCTCTCCCATGCCAACTCCGCTGTGGTGCTCTCTGCTGTGAAGGTGCTGA
TGAAGTTCATGGAGATGTTGTCTAAGGACTTGGACTACTACGGCACACTGCTCAAGAAGCTGGCCCCACCCCTGGTCACACTGCTGTCAG
CCGAGCCAGAGCTGCAGTATGTGGCCCTGCGCAACATCAATCTCATCGTGCAGAAAAGGTGGTGGCCAATGCAGTGGCAGCGCTCTCAGA
AATTGCCGAGTCTCACCCCAGCAGCAACCTGCTCGATCTGAACCCACAGTCCATCAACAAGCTGCTGACAGCCCTCAATGAGTGCACCGA

>56101_56101_6_MVP-AP1B1_MVP_chr16_29859133_ENST00000357402_AP1B1_chr22_29754725_ENST00000415447_length(amino acids)=882AA_BP=
MGLGVTMATEEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCTVANPVSRDAQGLVLFDVTGQVRLR
HADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTALHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEIIQATIIRQNQAL
RLRARKECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRDFRGVSRRTGEEWLVTVQDTEAHVPDVH
EEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKRVVKGEKSFFLQPGEQLEQGIQDVYVLSEQQGLLLRALQPLEEGEDEEKVSHQAG
DHWLIRGPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLADRGEKDTAK
SLQPLAPRNKTRVVSYRVPHNAAVQVYDYREKRARVVFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADH
ARLQLQLAYNWHFEVNDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGFETSEAKGPDGMALPRPRD
QAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSM
AVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAIGP

--------------------------------------------------------------
>56101_56101_7_MVP-AP1B1_MVP_chr16_29859133_ENST00000357402_AP1B1_chr22_29754725_ENST00000432560_length(transcript)=6259nt_BP=2814nt
ACCCCTGGGCTTGGCCTGCCTTGCCCTGCCGGGAAGTGATCCCCAAGGCAGGGTGAGAGTTCCCCATCTGAGGCGTTTGTTGCAGCTACC
TGCACTTCTAGATTCATCTTCTTGTGAGCCCTGGGCTTAGGAGTCACCATGGCAACTGAAGAGTTCATCATCCGCATCCCCCCATACCAC
TATATCCATGTGCTGGACCAGAACAGCAACGTGTCCCGTGTGGAGGTCGGGCCAAAGACCTACATCCGGCAGGACAATGAGAGGGTACTG
TTTGCCCCCATGCGCATGGTGACCGTCCCCCCACGTCACTACTGCACAGTGGCCAACCCTGTGTCTCGGGATGCCCAGGGCTTGGTGCTG
TTTGATGTCACAGGGCAAGTTCGGCTTCGCCACGCTGACCTCGAGATCCGGCTGGCCCAGGACCCCTTCCCCCTGTACCCAGGGGAGGTG
CTGGAAAAGGACATCACACCCCTGCAGGTGGTTCTGCCCAACACTGCCCTCCATCTAAAGGCGCTGCTTGATTTTGAGGATAAAGATGGA
GACAAGGTGGTGGCAGGAGATGAGTGGCTTTTCGAGGGACCTGGCACGTACATCCCCCGGAAGGAAGTGGAGGTCGTGGAGATCATTCAG
GCCACCATCATCAGGCAGAACCAGGCTCTGCGGCTCAGGGCCCGCAAGGAGTGCTGGGACCGGGACGGCAAGGAGAGGGTGACAGGGGAA
GAATGGCTGGTCACCACAGTAGGGGCGTACCTCCCAGCGGTGTTTGAGGAGGTTCTGGATTTGGTGGACGCCGTCATCCTTACGGAAAAG
ACAGCCCTGCACCTCCGGGCTCGGCGGAACTTCCGGGACTTCAGGGGAGTGTCCCGCCGCACTGGGGAGGAGTGGCTGGTAACAGTGCAG
GACACAGAGGCCCACGTGCCAGATGTCCACGAGGAGGTGCTGGGGGTTGTGCCCATCACCACCCTGGGCCCCCACAACTACTGCGTGATT
CTCGACCCTGTCGGACCGGATGGCAAGAATCAGCTGGGGCAGAAGCGCGTGGTCAAGGGAGAGAAGTCTTTTTTCCTCCAGCCAGGAGAG
CAGCTGGAACAAGGCATCCAGGATGTGTATGTGCTGTCGGAGCAGCAGGGGCTGCTGCTGAGGGCCCTGCAGCCCCTGGAGGAGGGGGAG
GATGAGGAGAAGGTCTCACACCAGGCTGGGGACCACTGGCTCATCCGCGGACCCCTGGAGTATGTGCCATCTGCCAAAGTGGAGGTGGTG
GAGGAGCGCCAGGCCATCCCTCTAGACGAGAACGAGGGCATCTATGTGCAGGATGTCAAGACCGGAAAGGTGCGCGCTGTGATTGGAAGC
ACCTACATGCTGACCCAGGACGAAGTCCTGTGGGAGAAAGAGCTGCCTCCCGGGGTGGAGGAGCTGCTGAACAAGGGGCAGGACCCTCTG
GCAGACAGGGGTGAGAAGGACACAGCTAAGAGCCTCCAGCCCTTGGCGCCCCGGAACAAGACCCGTGTGGTCAGCTACCGCGTGCCCCAC
AACGCTGCGGTGCAGGTGTACGACTACCGAGAGAAGCGAGCCCGCGTGGTCTTCGGGCCTGAGCTGGTGTCGCTGGGTCCTGAGGAGCAG
TTCACAGTGTTGTCCCTCTCAGCTGGGCGGCCCAAGCGTCCCCATGCCCGCCGTGCGCTCTGCCTGCTGCTGGGGCCTGACTTCTTCACA
GACGTCATCACCATCGAAACGGCGGATCATGCCAGGCTGCAACTGCAGCTGGCCTACAACTGGCACTTTGAGGTGAATGACCGGAAGGAC
CCCCAAGAGACGGCCAAGCTCTTTTCAGTGCCAGACTTTGTAGGTGATGCCTGCAAAGCCATCGCATCCCGGGTGCGGGGGGCCGTGGCC
TCTGTCACTTTCGATGACTTCCATAAGAACTCAGCCCGCATCATTCGCACTGCTGTCTTTGGCTTTGAGACCTCGGAAGCGAAGGGCCCC
GATGGCATGGCCCTGCCCAGGCCCCGGGACCAGGCTGTCTTCCCCCAAAACGGGCTGGTGGTCAGCAGTGTGGACGTGCAGTCAGTGGAG
CCTGTGGATCAGAGGACCCGGGACGCCCTGCAACGCAGCGTCCAGCTGGCCATCGAGATCACCACCAACTCCCAGGAAGCGGCGGCCAAG
CATGAGGCTCAGAGACTGGAGCAGGAAGCCCGCGGCCGGCTTGAGCGGCAGAAGATCCTGGACCAGTCAGAAGCCGAGAAAGCTCGCAAG
GAACTTTTGGAGCTGGAGGCTCTGAGCATGGCCGTGGAGAGCACCGGGACTGCCAAGGCGGAGGCCGAGTCCCGTGCGGAGGCAGCCCGG
ATTGAGGGAGAAGGGTCCGTGCTGCAGGCCAAGCTAAAAGCACAGGCCTTGGCCATTGAAACGGAGGCTGAGCTCCAGAGGGTCCAGAAG
GTCCGAGAGCTGGAACTGGTCTATGCCCGGGCCCAGCTGGAGCTGGAGGTGAGCAAGGCTCAGCAGCTGGCTGAGGTGGAGGTGAAGAAG
TTCAAGCAGATGACAGAGGCCATAGGCCCCAGCACCATCAGGGACCTTGCTGTGGCTGGGCCTGAGATGCAGTCCACTCCCATCAACCTC
TTCAACACAGCCTTTGGGCTGCTGGGGATGGGGCCCGAGGGTCAGCCCCTGGGCAGAAGGGTGGCCAGTGGGCCCAGCCCTGGGGAGGGG
ATATCCCCCCAGTCTGCTCAGGCCCCTCAAGCTCCTGGAGACAACCACGTGGTGCCTGTACTGCGCTAACTCCTGATTAATACAATGGAA
GTTTCTGGGCATTTACAATTTCAACTGTCCCTGAAGTGTCGAGCACCAGAGGTGTCCCAGCACGTGTACCAGGCCTACGAGACCATCCTC
AAGAACTGAGACCCCGGCCAGCGCCCACCCCAGCCTTCTGCCCGCCCCATCGAGGAGGCCCCTCGGGGGCAGCACATCTTCCTCCTCGCA
GGAGGGACCAGGCGGGGCTCCAGGCCACTCAGTGGGCTCCCTGGTCCTGATGGCAGAACCCACCCGATCCCTGGGGTAGGGCACCACCCC
CTCCTGGGGTGAGAGCGCAGTGCACTCCCGTGCTCTGGGACACCCCTGCTCCTGTGGCTGTGATGTGGGGTTAAGTGAGGTGGGGACCAA
AGGAAACAGAGCCAGAGCAGCCACAGAAGCTGTGCCTGAAGGGTGAGTGTGGAGCTTGCCCCTCCGGCTCACAGCCCCGGCAGCCCCTGG
CTCCTTGGTCTCTCCGGTTGGTGTTAAAGGGCCCTCCACTGCCACCTCTCATGGGATGGACCCTGCCAACCTGGCCTGGGTGTGCAGGGA
GGGGTTCCCCTTGGTACCAGGAGAGCTGCTCACTTAGGGCCTGGGGCTCAAGGAGCTGTAGGTGCCGGCAGAGGGGCAGAGCTAGGCTGG
GAGGAGCCCAGGGCCTGCACCACCCACTTGCAACCACCAGGCTGGTGCCCTGCAGCTGTGCCAGTTGGGCCACAGCCTCCCGAGTGCTGA
CCCACATGGTCAAGACCAGGCAGAAGCTCCCAGAGCCCCTGTCTCGGGCTCCCCACCGACTGGCAGCTGCACTATCCCCAACTCCCCACT
TCTGCCCCAAGGGTGGTCACTGCCTGTGATACATTCCTCAGTGTCGCCTCTGAGCCCAGGCCTCCTGCCACAAAGACTGGGCCGAGAGAT
GGGGCTGGGTAAGCGGGTGCGCCTCCTGTTTGGGTTTCTTCGGGGTTTCTCTGTAGTGTCTGCTGCCCTCCTCCTGGCCTCCCAGGTTTC
AGTTGTGTCTGACAGAGCATTAGGTTTTCCTGTTACTGCTGTGTAATAATAAAGAAAGATTCGGCTTTTGGCAATCACGGACACTTTTTT
CCCCTCCACCGAATGTCAGGATTGAAAGCTGCCTCCGAGTGGTTGGGGATGGTTTTCTGACCCTACGGTAACTAGATCTAATATATATCA
TCAGAAAATATATATTGTATGTTTACTCTTATTTTCAGAAAGAGAAAATGAATAAAAATGATGACATCAGGCTGCGAGCAGCAAGCTGCA
GAGCAGCAACATCTTCACTGTCGCCAAGAGGAACGTGGAGGGCCAGGACATGCTCTACCAGTCCCTGAAGCTGACCAACGGCATCTGGGT
GCTGGCGGAGCTGCGGATCCAGCCGGGCAACCCCAGCTGCACGACCGGCAGATGTTCCTGGCCACATGGAAGGATATTCCCAATGAGAAT
GAGGCCCAGTTCCAGATCAGAGACTGCCCCCTCAATGCAGGTGGCCGTGAAGAACAACATCGATGTCTTCTACTTCAGCACCTTGTACCC
ACTGCACATCCTCTTTGTGGAGGACGGGAAGATGGCTTTGGCCTGGCCCCCGCCACCCCCCTCCAGGTCCACGCGCCACTCAGCCCCAAC
CAGACAGTGGAGATCTCCCTGCCTCTCAGCACGGTGGGCTCGGTCATGAAGATGGAGCCTCTGAACAACCTCCAGGTCTGGCTCCCAGCC
ATGAAGGCTAAGGGGCTGGAGATCTCAGGCACCTTCACCCGCCAGGTGGGCTCCATCTCCATGGACCTGCAGCTGACCAACAAGGCCTTG
CAGGTCATGACCGACTTTGCCATCCAGTTCAACCGCAACAGATTGGGGGCACCAACTTCGTGGCACCTCCAACAGCAGCAGTACCAGCCA
ATCTTGGAGCACCCATCGGCAGTGGCCTGAGTGACCTCTTTGACCTGACCAGTGGCGTGGGCACCCTGTCAGGATCATATGTGGCCCCCA
AAGCAGAGTGAGAGCGCAGAGAGCCCTGAGACAGCCCCTACTGGAGCACCTCCTGGGGAGCAGCCAGATGTCATCCCCGCCCAGGGCGAC
CTGCTGGGTGACCTCCTCAACCTGGACCTCGGCCCCCCAGTGAGCGGCCCACCCCTGGCCACCTCCTCGGTGCAGATGGGAGCTGTGGAC
CTTCTTGGCGGTGGCCTTGACAGCCTGGACTCAGATAACCCAGACCTGCGGGACCGTGGCTACATCTACTGGCGCCTGCTGTCCACGGAC
CCGGTGGCAGCCAAGGAGGTGGTGTTGGCTGAGAAGCCACTCATCTCTGAAGAGACGGACCTCATCGAGCCCACACTGTTAGACGAGCTT
ATCTGCTACATCGGCACGCTGGCTTCCGTCTACCATAAGCCTCCCAGTGCCTTTGTGGAGGGGGGCCGGGGCGTCGTGCACAAGAGCCTG
CCACCTCGCACGGCCTCGTCCAGCTGCAGCTGCTGACAGCCATTGTGAAACTCTTTCTAAAGAAGCCAACAGAGACCCAGGAGCTGGTGC
AGCAGGTCCTCAGTTTGGCCACTCAGGTATGAGAGTGTGATTGCCACACTGTGTGAGAATCTGGACTCCCTGGATGAGCCTGAGGCCCGG
GCTGCCATGATCTGGATTGTGGGCGAGTACGCGGAACGGATCGACAACGCAGATGAGCTGCTGGAGAGCTTCCTCGAGGGCTTCCATGAC
GAGAGCACACAGCAATCTGCGGAGCGCTGTGTGAGCACGCTGCTCGACCTCATCCAGACCAAGGTCAACTATGTGGTCCAGGAGGCCATC
GTGGTCATCAAGGACATCTTCCGCAAGTACCCCAACAAGTGTTGGCAGAGCTGAAAGAGTACGCAACAGAAGTGGATGTGGACTTTGTAC
GGAAGGCTGTGCGTGCTATTGGCCGCTGCGCCATCAAGGTGGAGGCCTGAGATCCTGAAGCATGAGATGAAGGTGTTCTTCGTGAAGTAC
AACGACCCTATCTACGTGAAGCTGGAGAAGCTGGACATCATGATCCGCCTGGCCTCTCAGGCCAACATCGCCCAGCATCTGTGAGCGGGT
CACCCCCAGGCTCTCCCATGCCAACTCCGCTGTGGTGCTCTCTGCTGTGAAGGTGCTGATGAAGTTCATGGAGATGTTGTCTAAGGACTT
GGACTACTACGGCACACTGCTCAAGAAGCTGGCCCCACCCCTGGTCACACTGCTGTCAGCCGAGCCAGAGCTGCAGTATGTGGCCCTGCG
CAACATCAATCTCATCGTGCAGAAAAGGTGGTGGCCAATGCAGTGGCAGCGCTCTCAGAAATTGCCGAGTCTCACCCCAGCAGCAACCTG
CTCGATCTGAACCCACAGTCCATCAACAAGCTGCTGACAGCCCTCAATGAGTGCACCGAGTGGGGCCAGATCTTCATCCTGGACTGCCTC

>56101_56101_7_MVP-AP1B1_MVP_chr16_29859133_ENST00000357402_AP1B1_chr22_29754725_ENST00000432560_length(amino acids)=882AA_BP=
MGLGVTMATEEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCTVANPVSRDAQGLVLFDVTGQVRLR
HADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTALHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEIIQATIIRQNQAL
RLRARKECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRDFRGVSRRTGEEWLVTVQDTEAHVPDVH
EEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKRVVKGEKSFFLQPGEQLEQGIQDVYVLSEQQGLLLRALQPLEEGEDEEKVSHQAG
DHWLIRGPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLADRGEKDTAK
SLQPLAPRNKTRVVSYRVPHNAAVQVYDYREKRARVVFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADH
ARLQLQLAYNWHFEVNDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGFETSEAKGPDGMALPRPRD
QAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSM
AVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAIGP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MVP-AP1B1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MVP-AP1B1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MVP-AP1B1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource