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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MXI1-KLK3 (FusionGDB2 ID:56138)

Fusion Gene Summary for MXI1-KLK3

check button Fusion gene summary
Fusion gene informationFusion gene name: MXI1-KLK3
Fusion gene ID: 56138
HgeneTgene
Gene symbol

MXI1

KLK3

Gene ID

4601

3818

Gene nameMAX interactor 1, dimerization proteinkallikrein B1
SynonymsMAD2|MXD2|MXI|bHLHc11KLK3|PKK|PKKD|PPK
Cytomap

10q25.2

4q35.2

Type of geneprotein-codingprotein-coding
Descriptionmax-interacting protein 1MAX dimerization protein 2Max-related transcription factorclass C basic helix-loop-helix protein 11plasma kallikreinkallikrein B, plasma (Fletcher factor) 1kininogeninplasma prekallikrein
Modification date2020031320200320
UniProtAcc

P50539

P07288

Ensembl transtripts involved in fusion geneENST00000332674, ENST00000239007, 
ENST00000361248, ENST00000485566, 
ENST00000369612, ENST00000393134, 
ENST00000326003, ENST00000360617, 
ENST00000593997, ENST00000595952, 
ENST00000597483, 
Fusion gene scores* DoF score8 X 8 X 4=25630 X 32 X 3=2880
# samples 837
** MAII scorelog2(8/256*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(37/2880*10)=-2.96047163581336
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MXI1 [Title/Abstract] AND KLK3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMXI1(112046264)-KLK3(51358171), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMXI1

GO:0000122

negative regulation of transcription by RNA polymerase II

11875718

TgeneKLK3

GO:0031639

plasminogen activation

89876

TgeneKLK3

GO:0051919

positive regulation of fibrinolysis

89876


check buttonFusion gene breakpoints across MXI1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KLK3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HC-7742-01AMXI1chr10

112046264

-KLK3chr19

51358171

+


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Fusion Gene ORF analysis for MXI1-KLK3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000332674ENST00000326003MXI1chr10

112046264

-KLK3chr19

51358171

+
3UTR-intronENST00000332674ENST00000360617MXI1chr10

112046264

-KLK3chr19

51358171

+
3UTR-intronENST00000332674ENST00000593997MXI1chr10

112046264

-KLK3chr19

51358171

+
3UTR-intronENST00000332674ENST00000595952MXI1chr10

112046264

-KLK3chr19

51358171

+
3UTR-intronENST00000332674ENST00000597483MXI1chr10

112046264

-KLK3chr19

51358171

+
5CDS-intronENST00000239007ENST00000360617MXI1chr10

112046264

-KLK3chr19

51358171

+
5CDS-intronENST00000239007ENST00000593997MXI1chr10

112046264

-KLK3chr19

51358171

+
5CDS-intronENST00000239007ENST00000595952MXI1chr10

112046264

-KLK3chr19

51358171

+
5CDS-intronENST00000239007ENST00000597483MXI1chr10

112046264

-KLK3chr19

51358171

+
5CDS-intronENST00000361248ENST00000360617MXI1chr10

112046264

-KLK3chr19

51358171

+
5CDS-intronENST00000361248ENST00000593997MXI1chr10

112046264

-KLK3chr19

51358171

+
5CDS-intronENST00000361248ENST00000595952MXI1chr10

112046264

-KLK3chr19

51358171

+
5CDS-intronENST00000361248ENST00000597483MXI1chr10

112046264

-KLK3chr19

51358171

+
5CDS-intronENST00000485566ENST00000360617MXI1chr10

112046264

-KLK3chr19

51358171

+
5CDS-intronENST00000485566ENST00000593997MXI1chr10

112046264

-KLK3chr19

51358171

+
5CDS-intronENST00000485566ENST00000595952MXI1chr10

112046264

-KLK3chr19

51358171

+
5CDS-intronENST00000485566ENST00000597483MXI1chr10

112046264

-KLK3chr19

51358171

+
In-frameENST00000239007ENST00000326003MXI1chr10

112046264

-KLK3chr19

51358171

+
In-frameENST00000361248ENST00000326003MXI1chr10

112046264

-KLK3chr19

51358171

+
In-frameENST00000485566ENST00000326003MXI1chr10

112046264

-KLK3chr19

51358171

+
intron-3CDSENST00000369612ENST00000326003MXI1chr10

112046264

-KLK3chr19

51358171

+
intron-3CDSENST00000393134ENST00000326003MXI1chr10

112046264

-KLK3chr19

51358171

+
intron-intronENST00000369612ENST00000360617MXI1chr10

112046264

-KLK3chr19

51358171

+
intron-intronENST00000369612ENST00000593997MXI1chr10

112046264

-KLK3chr19

51358171

+
intron-intronENST00000369612ENST00000595952MXI1chr10

112046264

-KLK3chr19

51358171

+
intron-intronENST00000369612ENST00000597483MXI1chr10

112046264

-KLK3chr19

51358171

+
intron-intronENST00000393134ENST00000360617MXI1chr10

112046264

-KLK3chr19

51358171

+
intron-intronENST00000393134ENST00000593997MXI1chr10

112046264

-KLK3chr19

51358171

+
intron-intronENST00000393134ENST00000595952MXI1chr10

112046264

-KLK3chr19

51358171

+
intron-intronENST00000393134ENST00000597483MXI1chr10

112046264

-KLK3chr19

51358171

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361248MXI1chr10112046264-ENST00000326003KLK3chr1951358171+3651218820223014330
ENST00000239007MXI1chr10112046264-ENST00000326003KLK3chr1951358171+3887242422583250330
ENST00000485566MXI1chr10112046264-ENST00000326003KLK3chr1951358171+4218275525893581330

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361248ENST00000326003MXI1chr10112046264-KLK3chr1951358171+0.061733590.9382664
ENST00000239007ENST00000326003MXI1chr10112046264-KLK3chr1951358171+0.076426280.92357373
ENST00000485566ENST00000326003MXI1chr10112046264-KLK3chr1951358171+0.0448333620.9551667

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Fusion Genomic Features for MXI1-KLK3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MXI1-KLK3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:112046264/chr19:51358171)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MXI1

P50539

KLK3

P07288

FUNCTION: Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.FUNCTION: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMXI1chr10:112046264chr19:51358171ENST00000239007-6667_119735229.0DomainbHLH
HgeneMXI1chr10:112046264chr19:51358171ENST00000361248-5567_119689183.0DomainbHLH
TgeneKLK3chr10:112046264chr19:51358171ENST00000326003-1525_25815262.0DomainPeptidase S1
TgeneKLK3chr10:112046264chr19:51358171ENST000003606170525_2580239.0DomainPeptidase S1
TgeneKLK3chr10:112046264chr19:51358171ENST000005939970425_2580228.0DomainPeptidase S1
TgeneKLK3chr10:112046264chr19:51358171ENST000005959520525_2580219.0DomainPeptidase S1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMXI1chr10:112046264chr19:51358171ENST00000332674-1667_1190296.0DomainbHLH
HgeneMXI1chr10:112046264chr19:51358171ENST00000369612-1667_1190193.0DomainbHLH


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Fusion Gene Sequence for MXI1-KLK3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>56138_56138_1_MXI1-KLK3_MXI1_chr10_112046264_ENST00000239007_KLK3_chr19_51358171_ENST00000326003_length(transcript)=3887nt_BP=2424nt
GGTAAACAAACCACGCGCGGGCTGCCCGCGGCACGGCGGGCGCGGCTGGCGCGGCTGGGGCGGCAGGGGCGGCGGAGAGCGCGCCGAGCC
GCGGCCGAGCTGGCCCGCCCGCCCGTCGCACATGTTCCGGAACGGCGCCCGGCCGTAGCCGCCTGCGGCGCCTCCTGTCGGCCCGAGAAG
GGAGTGCGGAGAGGCGCCGGTCGCCACCCGCGGTGCCCATGGAGCGGGTGAAGATGATCAACGTGCAGCGTCTGCTGGAGGCTGCCGAGT
TTTTGGAGCGCCGGGAGCGAGAGTGTGAACATGGCTACGCCTCTTCATTCCCGTCCATGCCGAGCCCCCGACTGCAGCATTCAAAGCCCC
CACGGAGGTTGAGCCGGGCACAGAAACACAGCAGCGGGAGCAGCAACACCAGCACTGCCAACAGATCTACACACAATGAGCTGGAAAAGA
ATCGACGAGCTCATCTGCGCCTTTGTTTAGAACGCTTAAAAGTTCTGATTCCACTAGGACCAGACTGCACCCGGCACACAACACTTGGTT
TGCTCAACAAAGCCAAAGCACACATCAAGAAACTTGAAGAAGCTGAAAGAAAAAGCCAGCACCAGCTCGAGAATTTGGAACGAGAACAGA
GATTTTTAAAGTGGCGACTGGAACAGCTGCAGGGTCCTCAGGAGATGGAACGAATACGAATGGACAGCATTGGATCAACTATTTCTTCAG
ATCGTTCTGATTCAGAGCGAGAGGAGATTGAAGTGGATGTTGAAAGCACAGAGTTCTCCCATGGAGAAGTGGACAATATAAGTACCACCA
GCATCAGTGACATTGATGACCACAGCAGCCTGCCGAGTATTGGGAGTGACGAGGGTTACTCCAGTGCCAGTGTCAAACTTTCATTCACTT
CATAGAACCCAGCATGACATAACAGTGCAGGGCAAAATATTCACTGGGCCAATTCAATACAAACAATCTCTTAAATTGGGTTCATGATGC
AGTCTCCTCTTTAAAACAAAACAAAACAAAACAAAACTATACTTGAACAAAAGGGTCAGAGGACCTGTATTTAAGCAAATACTTAGCAAA
AAGTGGGGCAGAGCCTCCCAAGGAGAACAAATATTCAGAATATTCATATTGGAAAAATCACAATTTTTAATGGCAGCAGAAAACTTGTGT
GAAATTTTCTTGATTTGAGTTGATTGAGAAGAGGACATTGGAGATGCCATCCTCTTTCTCTTTTCTAGTTTGCTCATACTACATTGAGTA
GACACATTTAAGGATGGGGTTATGAACCCTTCCTGAGCTTTATGGTCCTAAAAGCAAAATAAAAACTATTCGAATGAAAAGACAAGAAAA
TCAGGTATTAATCTTGGATAGCTAATAATGAGCTATTAAAACTCAGCCTGGGACAGTTTATCATGAAGCCTGTGGATGATCAATCCTTTA
TTATTATTTTTTTTTTTTGAAAAAAGCTCATTTCATGCTCTGCAAAAGGAGAGACTCCCATGAAGCCTTTTGAAAGGGATCATCATGCAG
CTCAACTTTCTGTTGGATTCCATGCTAAGCAAGCTAACCTTATCCTGCATTGTTAGCACTAGGCACCCAGCTGCCACCTCTCCATCCTGC
TGCCCTTAGGCCACATGGGAGCAGTCCATGCATGACAGCCTCTATCCTACAAGGCCTATGAGTATGGATTGGGGGGGCCAAAAGGAAAAA
GCTCCATGTGCCTCTTTGTCTGCGTGGGTCAGAAGAGTTGTGCACGCAGATTAGCAGGCCAAGGTCTGAGCCACAGCAGCATTTTTATTT
CAGATTTTGATAACTGTTTATATGTGTTGAAAACCAAAATGACATCTTTTTAAAGCTTATCCATAAAAAAAAATAGATGTCTTTTATAGT
GGAAAAACACATGGGGAAAAAAATCATCTATTTTGATGCAGCATTTGATAATGATAAAACACCTCACACCTCACTCTTTATAGTGCACAA
AATGAATGAGGTCTGGGCTAGGTAGAAAAAGGGTCAATGCTATTTTTGTTTTTAGAATCATTACCTTTTACCAGCTTTTAACCATCTGAT
ATCTATAGTAGACACACTATCATAGTTAACATAGTAAGTTCAGCACTTGTCTCATTTTAATGTAAAGATTTGCTTCCATTTTCCTACAGG
CAGTCTCTCTCTTCCTCACAGTCCCACTGTGCAGGTGCTATTGTTACTCTTACGAATATTTTCAGTAATGTTATTTTCTTCTAAGTGAAA
TTTCTAGCCTGCACTTTGATGTCATGTGTTCCCTTTGTCTTTCAAACTCCAAGGTTCCCTTGTGGCCCTCTCCCTTACCCTGGGAAGGCC
TCTTGGAGACCTTACCCCTGGCTGTTTGGACTTTGTATACTTTAAATAATTTAACTACCCTTAATTACTTAAAAAAAAAAAAAAAGCCCC
AAGCTTACCACCTGCACCCGGAGAGCTGTGTCACCATGTGGGTCCCGGTTGTCTTCCTCACCCTGTCCGTGACGTGGATTGGTGCTGCAC
CCCTCATCCTGTCTCGGATTGTGGGAGGCTGGGAGTGCGAGAAGCATTCCCAACCCTGGCAGGTGCTTGTGGCCTCTCGTGGCAGGGCAG
TCTGCGGCGGTGTTCTGGTGCACCCCCAGTGGGTCCTCACAGCTGCCCACTGCATCAGGAACAAAAGCGTGATCTTGCTGGGTCGGCACA
GCCTGTTTCATCCTGAAGACACAGGCCAGGTATTTCAGGTCAGCCACAGCTTCCCACACCCGCTCTACGATATGAGCCTCCTGAAGAATC
GATTCCTCAGGCCAGGTGATGACTCCAGCCACGACCTCATGCTGCTCCGCCTGTCAGAGCCTGCCGAGCTCACGGATGCTGTGAAGGTCA
TGGACCTGCCCACCCAGGAGCCAGCACTGGGGACCACCTGCTACGCCTCAGGCTGGGGCAGCATTGAACCAGAGGAGTTCTTGACCCCAA
AGAAACTTCAGTGTGTGGACCTCCATGTTATTTCCAATGACGTGTGTGCGCAAGTTCACCCTCAGAAGGTGACCAAGTTCATGCTGTGTG
CTGGACGCTGGACAGGGGGCAAAAGCACCTGCTCGGGTGATTCTGGGGGCCCACTTGTCTGTAATGGTGTGCTTCAAGGTATCACGTCAT
GGGGCAGTGAACCATGTGCCCTGCCCGAAAGGCCTTCCCTGTACACCAAGGTGGTGCATTACCGGAAGTGGATCAAGGACACCATCGTGG
CCAACCCCTGAGCACCCCTATCAACCCCCTATTGTAGTAAACTTGGAACCTTGGAAATGACCAGGCCAAGACTCAAGCCTCCCCAGTTCT
ACTGACCTTTGTCCTTAGGTGTGAGGTCCAGGGTTGCTAGGAAAAGAAATCAGCAGACACAGGTGTAGACCAGAGTGTTTCTTAAATGGT
GTAATTTTGTCCTCTCTGTGTCCTGGGGAATACTGGCCATGCCTGGAGACATATCACTCAATTTCTCTGAGGACACAGATAGGATGGGGT
GTCTGTGTTATTTGTGGGGTACAGAGATGAAAGAGGGGTGGGATCCACACTGAGAGAGTGGAGAGTGACATGTGCTGGACACTGTCCATG
AAGCACTGAGCAGAAGCTGGAGGCACAACGCACCAGACACTCACAGCAAGGATGGAGCTGAAAACATAACCCACTCTGTCCTGGAGGCAC
TGGGAAGCCTAGAGAAGGCTGTGAGCCAAGGAGGGAGGGTCTTCCTTTGGCATGGGATGGGGATGAAGTAAGGAGAGGGACTGGACCCCC
TGGAAGCTGATTCACTATGGGGGGAGGTGTATTGAAGTCCTCCAGACAACCCTCAGATTTGATGATTTCCTAGTAGAACTCACAGAAATA

>56138_56138_1_MXI1-KLK3_MXI1_chr10_112046264_ENST00000239007_KLK3_chr19_51358171_ENST00000326003_length(amino acids)=330AA_BP=89
MHFDVMCSLCLSNSKVPLWPSPLPWEGLLETLPLAVWTLYTLNNLTTLNYLKKKKKPQAYHLHPESCVTMWVPVVFLTLSVTWIGAAPLI
LSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWVLTAAHCIRNKSVILLGRHSLFHPEDTGQVFQVSHSFPHPLYDMSLLKNRFL
RPGDDSSHDLMLLRLSEPAELTDAVKVMDLPTQEPALGTTCYASGWGSIEPEEFLTPKKLQCVDLHVISNDVCAQVHPQKVTKFMLCAGR

--------------------------------------------------------------
>56138_56138_2_MXI1-KLK3_MXI1_chr10_112046264_ENST00000361248_KLK3_chr19_51358171_ENST00000326003_length(transcript)=3651nt_BP=2188nt
CATCGCCCGAGGCGTCCGCCCTGCAAATCTGCCAGCCCCCGAGAGGGGTTTGGAACCTTAGCACCCAAGTCTAAGTCAACTTCATAGTGT
GAACATGGCTACGCCTCTTCATTCCCGTCCATGCCGAGCCCCCGACTGCAGCATTCAAAGCCCCCACGGAGGTTGAGCCGGGCACAGAAA
CACAGCAGCGGGAGCAGCAACACCAGCACTGCCAACAGACGAGCTCATCTGCGCCTTTGTTTAGAACGCTTAAAAGTTCTGATTCCACTA
GGACCAGACTGCACCCGGCACACAACACTTGGTTTGCTCAACAAAGCCAAAGCACACATCAAGAAACTTGAAGAAGCTGAAAGAAAAAGC
CAGCACCAGCTCGAGAATTTGGAACGAGAACAGAGATTTTTAAAGTGGCGACTGGAACAGCTGCAGGGTCCTCAGGAGATGGAACGAATA
CGAATGGACAGCATTGGATCAACTATTTCTTCAGATCGTTCTGATTCAGAGCGAGAGGAGATTGAAGTGGATGTTGAAAGCACAGAGTTC
TCCCATGGAGAAGTGGACAATATAAGTACCACCAGCATCAGTGACATTGATGACCACAGCAGCCTGCCGAGTATTGGGAGTGACGAGGGT
TACTCCAGTGCCAGTGTCAAACTTTCATTCACTTCATAGAACCCAGCATGACATAACAGTGCAGGGCAAAATATTCACTGGGCCAATTCA
ATACAAACAATCTCTTAAATTGGGTTCATGATGCAGTCTCCTCTTTAAAACAAAACAAAACAAAACAAAACTATACTTGAACAAAAGGGT
CAGAGGACCTGTATTTAAGCAAATACTTAGCAAAAAGTGGGGCAGAGCCTCCCAAGGAGAACAAATATTCAGAATATTCATATTGGAAAA
ATCACAATTTTTAATGGCAGCAGAAAACTTGTGTGAAATTTTCTTGATTTGAGTTGATTGAGAAGAGGACATTGGAGATGCCATCCTCTT
TCTCTTTTCTAGTTTGCTCATACTACATTGAGTAGACACATTTAAGGATGGGGTTATGAACCCTTCCTGAGCTTTATGGTCCTAAAAGCA
AAATAAAAACTATTCGAATGAAAAGACAAGAAAATCAGGTATTAATCTTGGATAGCTAATAATGAGCTATTAAAACTCAGCCTGGGACAG
TTTATCATGAAGCCTGTGGATGATCAATCCTTTATTATTATTTTTTTTTTTTGAAAAAAGCTCATTTCATGCTCTGCAAAAGGAGAGACT
CCCATGAAGCCTTTTGAAAGGGATCATCATGCAGCTCAACTTTCTGTTGGATTCCATGCTAAGCAAGCTAACCTTATCCTGCATTGTTAG
CACTAGGCACCCAGCTGCCACCTCTCCATCCTGCTGCCCTTAGGCCACATGGGAGCAGTCCATGCATGACAGCCTCTATCCTACAAGGCC
TATGAGTATGGATTGGGGGGGCCAAAAGGAAAAAGCTCCATGTGCCTCTTTGTCTGCGTGGGTCAGAAGAGTTGTGCACGCAGATTAGCA
GGCCAAGGTCTGAGCCACAGCAGCATTTTTATTTCAGATTTTGATAACTGTTTATATGTGTTGAAAACCAAAATGACATCTTTTTAAAGC
TTATCCATAAAAAAAAATAGATGTCTTTTATAGTGGAAAAACACATGGGGAAAAAAATCATCTATTTTGATGCAGCATTTGATAATGATA
AAACACCTCACACCTCACTCTTTATAGTGCACAAAATGAATGAGGTCTGGGCTAGGTAGAAAAAGGGTCAATGCTATTTTTGTTTTTAGA
ATCATTACCTTTTACCAGCTTTTAACCATCTGATATCTATAGTAGACACACTATCATAGTTAACATAGTAAGTTCAGCACTTGTCTCATT
TTAATGTAAAGATTTGCTTCCATTTTCCTACAGGCAGTCTCTCTCTTCCTCACAGTCCCACTGTGCAGGTGCTATTGTTACTCTTACGAA
TATTTTCAGTAATGTTATTTTCTTCTAAGTGAAATTTCTAGCCTGCACTTTGATGTCATGTGTTCCCTTTGTCTTTCAAACTCCAAGGTT
CCCTTGTGGCCCTCTCCCTTACCCTGGGAAGGCCTCTTGGAGACCTTACCCCTGGCTGTTTGGACTTTGTATACTTTAAATAATTTAACT
ACCCTTAATTACTTAAAAAAAAAAAAAAAGCCCCAAGCTTACCACCTGCACCCGGAGAGCTGTGTCACCATGTGGGTCCCGGTTGTCTTC
CTCACCCTGTCCGTGACGTGGATTGGTGCTGCACCCCTCATCCTGTCTCGGATTGTGGGAGGCTGGGAGTGCGAGAAGCATTCCCAACCC
TGGCAGGTGCTTGTGGCCTCTCGTGGCAGGGCAGTCTGCGGCGGTGTTCTGGTGCACCCCCAGTGGGTCCTCACAGCTGCCCACTGCATC
AGGAACAAAAGCGTGATCTTGCTGGGTCGGCACAGCCTGTTTCATCCTGAAGACACAGGCCAGGTATTTCAGGTCAGCCACAGCTTCCCA
CACCCGCTCTACGATATGAGCCTCCTGAAGAATCGATTCCTCAGGCCAGGTGATGACTCCAGCCACGACCTCATGCTGCTCCGCCTGTCA
GAGCCTGCCGAGCTCACGGATGCTGTGAAGGTCATGGACCTGCCCACCCAGGAGCCAGCACTGGGGACCACCTGCTACGCCTCAGGCTGG
GGCAGCATTGAACCAGAGGAGTTCTTGACCCCAAAGAAACTTCAGTGTGTGGACCTCCATGTTATTTCCAATGACGTGTGTGCGCAAGTT
CACCCTCAGAAGGTGACCAAGTTCATGCTGTGTGCTGGACGCTGGACAGGGGGCAAAAGCACCTGCTCGGGTGATTCTGGGGGCCCACTT
GTCTGTAATGGTGTGCTTCAAGGTATCACGTCATGGGGCAGTGAACCATGTGCCCTGCCCGAAAGGCCTTCCCTGTACACCAAGGTGGTG
CATTACCGGAAGTGGATCAAGGACACCATCGTGGCCAACCCCTGAGCACCCCTATCAACCCCCTATTGTAGTAAACTTGGAACCTTGGAA
ATGACCAGGCCAAGACTCAAGCCTCCCCAGTTCTACTGACCTTTGTCCTTAGGTGTGAGGTCCAGGGTTGCTAGGAAAAGAAATCAGCAG
ACACAGGTGTAGACCAGAGTGTTTCTTAAATGGTGTAATTTTGTCCTCTCTGTGTCCTGGGGAATACTGGCCATGCCTGGAGACATATCA
CTCAATTTCTCTGAGGACACAGATAGGATGGGGTGTCTGTGTTATTTGTGGGGTACAGAGATGAAAGAGGGGTGGGATCCACACTGAGAG
AGTGGAGAGTGACATGTGCTGGACACTGTCCATGAAGCACTGAGCAGAAGCTGGAGGCACAACGCACCAGACACTCACAGCAAGGATGGA
GCTGAAAACATAACCCACTCTGTCCTGGAGGCACTGGGAAGCCTAGAGAAGGCTGTGAGCCAAGGAGGGAGGGTCTTCCTTTGGCATGGG
ATGGGGATGAAGTAAGGAGAGGGACTGGACCCCCTGGAAGCTGATTCACTATGGGGGGAGGTGTATTGAAGTCCTCCAGACAACCCTCAG

>56138_56138_2_MXI1-KLK3_MXI1_chr10_112046264_ENST00000361248_KLK3_chr19_51358171_ENST00000326003_length(amino acids)=330AA_BP=89
MHFDVMCSLCLSNSKVPLWPSPLPWEGLLETLPLAVWTLYTLNNLTTLNYLKKKKKPQAYHLHPESCVTMWVPVVFLTLSVTWIGAAPLI
LSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWVLTAAHCIRNKSVILLGRHSLFHPEDTGQVFQVSHSFPHPLYDMSLLKNRFL
RPGDDSSHDLMLLRLSEPAELTDAVKVMDLPTQEPALGTTCYASGWGSIEPEEFLTPKKLQCVDLHVISNDVCAQVHPQKVTKFMLCAGR

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>56138_56138_3_MXI1-KLK3_MXI1_chr10_112046264_ENST00000485566_KLK3_chr19_51358171_ENST00000326003_length(transcript)=4218nt_BP=2755nt
GGGCCTTTGAATACCTGCGGGGTGATGAGATGGGGTCCCTTTAGCGGTGGCAGCCCAAGGGGCTGTAGAGATGGCGCAGAAAGACCAGGA
ACTCGGAGACTGTGGTGTCGAGAGAGAAAATGTCTTTCTAAGACTTGTTCGAAGTACACAAAAATATTGGGCTTAAAGAGACTCTTTAGA
ACAGAGAGAGTTGAAAGTAAAGGGGAATTTTTGAGGCAAGCGAAGTCAATGAGGTGAATGGTAACTGGTCACAAAATTTTTGTTCTAAAG
CATCTGAAATCTCAAGTTCTTGGGAGAGAAGGATTTTGGAAAGGGGGGATAAACTCTTTGGTTTAGAGGAGGTATCAAAACACCTTCCAG
CTGGTGGGGTGTCACAGGATTGATGTCCAGGCGAGGGACATTAATTTTCTAACCAAAAAGAGTGGAAACATTTTACCTCTTTTCCTGCTT
TCAAAAACCTGTTACTGCAAAGACCTCGGATTTGTGGGTCAATGGATTTGGGTACTATATTCTTCTTACCGTATCTTTTTTTCTTGCTTT
CTTCAGAGTGTGAACATGGCTACGCCTCTTCATTCCCGTCCATGCCGAGCCCCCGACTGCAGCATTCAAAGCCCCCACGGAGGTTGAGCC
GGGCACAGAAACACAGCAGCGGGAGCAGCAACACCAGCACTGCCAACAGATCTACACACAATGAGCTGGAAAAGAATCGCTTGAAGAATT
GGTTGGTTGGGAGAAGGGATACCAGAGGCATGAAGATGCTTTTGAAGGCTATTGCAGTAATCTAGACGAGCTCATCTGCGCCTTTGTTTA
GAACGCTTAAAAGTTCTGATTCCACTAGGACCAGACTGCACCCGGCACACAACACTTGGTTTGCTCAACAAAGCCAAAGCACACATCAAG
AAACTTGAAGAAGCTGAAAGAAAAAGCCAGCACCAGCTCGAGAATTTGGAACGAGAACAGAGATTTTTAAAGTGGCGACTGGAACAGCTG
CAGGGTCCTCAGGAGATGGAACGAATACGAATGGACAGCATTGGATCAACTATTTCTTCAGATCGTTCTGATTCAGAGCGAGAGGAGATT
GAAGTGGATGTTGAAAGCACAGAGTTCTCCCATGGAGAAGTGGACAATATAAGTACCACCAGCATCAGTGACATTGATGACCACAGCAGC
CTGCCGAGTATTGGGAGTGACGAGGGTTACTCCAGTGCCAGTGTCAAACTTTCATTCACTTCATAGAACCCAGCATGACATAACAGTGCA
GGGCAAAATATTCACTGGGCCAATTCAATACAAACAATCTCTTAAATTGGGTTCATGATGCAGTCTCCTCTTTAAAACAAAACAAAACAA
AACAAAACTATACTTGAACAAAAGGGTCAGAGGACCTGTATTTAAGCAAATACTTAGCAAAAAGTGGGGCAGAGCCTCCCAAGGAGAACA
AATATTCAGAATATTCATATTGGAAAAATCACAATTTTTAATGGCAGCAGAAAACTTGTGTGAAATTTTCTTGATTTGAGTTGATTGAGA
AGAGGACATTGGAGATGCCATCCTCTTTCTCTTTTCTAGTTTGCTCATACTACATTGAGTAGACACATTTAAGGATGGGGTTATGAACCC
TTCCTGAGCTTTATGGTCCTAAAAGCAAAATAAAAACTATTCGAATGAAAAGACAAGAAAATCAGGTATTAATCTTGGATAGCTAATAAT
GAGCTATTAAAACTCAGCCTGGGACAGTTTATCATGAAGCCTGTGGATGATCAATCCTTTATTATTATTTTTTTTTTTTGAAAAAAGCTC
ATTTCATGCTCTGCAAAAGGAGAGACTCCCATGAAGCCTTTTGAAAGGGATCATCATGCAGCTCAACTTTCTGTTGGATTCCATGCTAAG
CAAGCTAACCTTATCCTGCATTGTTAGCACTAGGCACCCAGCTGCCACCTCTCCATCCTGCTGCCCTTAGGCCACATGGGAGCAGTCCAT
GCATGACAGCCTCTATCCTACAAGGCCTATGAGTATGGATTGGGGGGGCCAAAAGGAAAAAGCTCCATGTGCCTCTTTGTCTGCGTGGGT
CAGAAGAGTTGTGCACGCAGATTAGCAGGCCAAGGTCTGAGCCACAGCAGCATTTTTATTTCAGATTTTGATAACTGTTTATATGTGTTG
AAAACCAAAATGACATCTTTTTAAAGCTTATCCATAAAAAAAAATAGATGTCTTTTATAGTGGAAAAACACATGGGGAAAAAAATCATCT
ATTTTGATGCAGCATTTGATAATGATAAAACACCTCACACCTCACTCTTTATAGTGCACAAAATGAATGAGGTCTGGGCTAGGTAGAAAA
AGGGTCAATGCTATTTTTGTTTTTAGAATCATTACCTTTTACCAGCTTTTAACCATCTGATATCTATAGTAGACACACTATCATAGTTAA
CATAGTAAGTTCAGCACTTGTCTCATTTTAATGTAAAGATTTGCTTCCATTTTCCTACAGGCAGTCTCTCTCTTCCTCACAGTCCCACTG
TGCAGGTGCTATTGTTACTCTTACGAATATTTTCAGTAATGTTATTTTCTTCTAAGTGAAATTTCTAGCCTGCACTTTGATGTCATGTGT
TCCCTTTGTCTTTCAAACTCCAAGGTTCCCTTGTGGCCCTCTCCCTTACCCTGGGAAGGCCTCTTGGAGACCTTACCCCTGGCTGTTTGG
ACTTTGTATACTTTAAATAATTTAACTACCCTTAATTACTTAAAAAAAAAAAAAAAGCCCCAAGCTTACCACCTGCACCCGGAGAGCTGT
GTCACCATGTGGGTCCCGGTTGTCTTCCTCACCCTGTCCGTGACGTGGATTGGTGCTGCACCCCTCATCCTGTCTCGGATTGTGGGAGGC
TGGGAGTGCGAGAAGCATTCCCAACCCTGGCAGGTGCTTGTGGCCTCTCGTGGCAGGGCAGTCTGCGGCGGTGTTCTGGTGCACCCCCAG
TGGGTCCTCACAGCTGCCCACTGCATCAGGAACAAAAGCGTGATCTTGCTGGGTCGGCACAGCCTGTTTCATCCTGAAGACACAGGCCAG
GTATTTCAGGTCAGCCACAGCTTCCCACACCCGCTCTACGATATGAGCCTCCTGAAGAATCGATTCCTCAGGCCAGGTGATGACTCCAGC
CACGACCTCATGCTGCTCCGCCTGTCAGAGCCTGCCGAGCTCACGGATGCTGTGAAGGTCATGGACCTGCCCACCCAGGAGCCAGCACTG
GGGACCACCTGCTACGCCTCAGGCTGGGGCAGCATTGAACCAGAGGAGTTCTTGACCCCAAAGAAACTTCAGTGTGTGGACCTCCATGTT
ATTTCCAATGACGTGTGTGCGCAAGTTCACCCTCAGAAGGTGACCAAGTTCATGCTGTGTGCTGGACGCTGGACAGGGGGCAAAAGCACC
TGCTCGGGTGATTCTGGGGGCCCACTTGTCTGTAATGGTGTGCTTCAAGGTATCACGTCATGGGGCAGTGAACCATGTGCCCTGCCCGAA
AGGCCTTCCCTGTACACCAAGGTGGTGCATTACCGGAAGTGGATCAAGGACACCATCGTGGCCAACCCCTGAGCACCCCTATCAACCCCC
TATTGTAGTAAACTTGGAACCTTGGAAATGACCAGGCCAAGACTCAAGCCTCCCCAGTTCTACTGACCTTTGTCCTTAGGTGTGAGGTCC
AGGGTTGCTAGGAAAAGAAATCAGCAGACACAGGTGTAGACCAGAGTGTTTCTTAAATGGTGTAATTTTGTCCTCTCTGTGTCCTGGGGA
ATACTGGCCATGCCTGGAGACATATCACTCAATTTCTCTGAGGACACAGATAGGATGGGGTGTCTGTGTTATTTGTGGGGTACAGAGATG
AAAGAGGGGTGGGATCCACACTGAGAGAGTGGAGAGTGACATGTGCTGGACACTGTCCATGAAGCACTGAGCAGAAGCTGGAGGCACAAC
GCACCAGACACTCACAGCAAGGATGGAGCTGAAAACATAACCCACTCTGTCCTGGAGGCACTGGGAAGCCTAGAGAAGGCTGTGAGCCAA
GGAGGGAGGGTCTTCCTTTGGCATGGGATGGGGATGAAGTAAGGAGAGGGACTGGACCCCCTGGAAGCTGATTCACTATGGGGGGAGGTG

>56138_56138_3_MXI1-KLK3_MXI1_chr10_112046264_ENST00000485566_KLK3_chr19_51358171_ENST00000326003_length(amino acids)=330AA_BP=89
MHFDVMCSLCLSNSKVPLWPSPLPWEGLLETLPLAVWTLYTLNNLTTLNYLKKKKKPQAYHLHPESCVTMWVPVVFLTLSVTWIGAAPLI
LSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWVLTAAHCIRNKSVILLGRHSLFHPEDTGQVFQVSHSFPHPLYDMSLLKNRFL
RPGDDSSHDLMLLRLSEPAELTDAVKVMDLPTQEPALGTTCYASGWGSIEPEEFLTPKKLQCVDLHVISNDVCAQVHPQKVTKFMLCAGR

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Fusion Gene PPI Analysis for MXI1-KLK3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MXI1-KLK3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MXI1-KLK3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource