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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MXI1-MXI1 (FusionGDB2 ID:56139)

Fusion Gene Summary for MXI1-MXI1

check button Fusion gene summary
Fusion gene informationFusion gene name: MXI1-MXI1
Fusion gene ID: 56139
HgeneTgene
Gene symbol

MXI1

MXI1

Gene ID

4601

4601

Gene nameMAX interactor 1, dimerization proteinMAX interactor 1, dimerization protein
SynonymsMAD2|MXD2|MXI|bHLHc11MAD2|MXD2|MXI|bHLHc11
Cytomap

10q25.2

10q25.2

Type of geneprotein-codingprotein-coding
Descriptionmax-interacting protein 1MAX dimerization protein 2Max-related transcription factorclass C basic helix-loop-helix protein 11max-interacting protein 1MAX dimerization protein 2Max-related transcription factorclass C basic helix-loop-helix protein 11
Modification date2020031320200313
UniProtAcc

P50539

P50539

Ensembl transtripts involved in fusion geneENST00000239007, ENST00000332674, 
ENST00000361248, ENST00000485566, 
ENST00000369612, ENST00000393134, 
ENST00000239007, ENST00000393134, 
ENST00000332674, ENST00000361248, 
ENST00000369612, ENST00000485566, 
Fusion gene scores* DoF score8 X 8 X 4=25617 X 10 X 9=1530
# samples 819
** MAII scorelog2(8/256*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1530*10)=-3.00946032924907
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MXI1 [Title/Abstract] AND MXI1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMXI1(112046160)-MXI1(111985928), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMXI1

GO:0000122

negative regulation of transcription by RNA polymerase II

11875718

TgeneMXI1

GO:0000122

negative regulation of transcription by RNA polymerase II

11875718


check buttonFusion gene breakpoints across MXI1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MXI1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AL07648MXI1chr10

112046160

-MXI1chr10

111985928

+


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Fusion Gene ORF analysis for MXI1-MXI1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000239007ENST00000239007MXI1chr10

112046160

-MXI1chr10

111985928

+
3UTR-5UTRENST00000239007ENST00000393134MXI1chr10

112046160

-MXI1chr10

111985928

+
3UTR-5UTRENST00000332674ENST00000239007MXI1chr10

112046160

-MXI1chr10

111985928

+
3UTR-5UTRENST00000332674ENST00000393134MXI1chr10

112046160

-MXI1chr10

111985928

+
3UTR-5UTRENST00000361248ENST00000239007MXI1chr10

112046160

-MXI1chr10

111985928

+
3UTR-5UTRENST00000361248ENST00000393134MXI1chr10

112046160

-MXI1chr10

111985928

+
3UTR-5UTRENST00000485566ENST00000239007MXI1chr10

112046160

-MXI1chr10

111985928

+
3UTR-5UTRENST00000485566ENST00000393134MXI1chr10

112046160

-MXI1chr10

111985928

+
3UTR-intronENST00000239007ENST00000332674MXI1chr10

112046160

-MXI1chr10

111985928

+
3UTR-intronENST00000239007ENST00000361248MXI1chr10

112046160

-MXI1chr10

111985928

+
3UTR-intronENST00000239007ENST00000369612MXI1chr10

112046160

-MXI1chr10

111985928

+
3UTR-intronENST00000239007ENST00000485566MXI1chr10

112046160

-MXI1chr10

111985928

+
3UTR-intronENST00000332674ENST00000332674MXI1chr10

112046160

-MXI1chr10

111985928

+
3UTR-intronENST00000332674ENST00000361248MXI1chr10

112046160

-MXI1chr10

111985928

+
3UTR-intronENST00000332674ENST00000369612MXI1chr10

112046160

-MXI1chr10

111985928

+
3UTR-intronENST00000332674ENST00000485566MXI1chr10

112046160

-MXI1chr10

111985928

+
3UTR-intronENST00000361248ENST00000332674MXI1chr10

112046160

-MXI1chr10

111985928

+
3UTR-intronENST00000361248ENST00000361248MXI1chr10

112046160

-MXI1chr10

111985928

+
3UTR-intronENST00000361248ENST00000369612MXI1chr10

112046160

-MXI1chr10

111985928

+
3UTR-intronENST00000361248ENST00000485566MXI1chr10

112046160

-MXI1chr10

111985928

+
3UTR-intronENST00000485566ENST00000332674MXI1chr10

112046160

-MXI1chr10

111985928

+
3UTR-intronENST00000485566ENST00000361248MXI1chr10

112046160

-MXI1chr10

111985928

+
3UTR-intronENST00000485566ENST00000369612MXI1chr10

112046160

-MXI1chr10

111985928

+
3UTR-intronENST00000485566ENST00000485566MXI1chr10

112046160

-MXI1chr10

111985928

+
intron-5UTRENST00000369612ENST00000239007MXI1chr10

112046160

-MXI1chr10

111985928

+
intron-5UTRENST00000369612ENST00000393134MXI1chr10

112046160

-MXI1chr10

111985928

+
intron-5UTRENST00000393134ENST00000239007MXI1chr10

112046160

-MXI1chr10

111985928

+
intron-5UTRENST00000393134ENST00000393134MXI1chr10

112046160

-MXI1chr10

111985928

+
intron-intronENST00000369612ENST00000332674MXI1chr10

112046160

-MXI1chr10

111985928

+
intron-intronENST00000369612ENST00000361248MXI1chr10

112046160

-MXI1chr10

111985928

+
intron-intronENST00000369612ENST00000369612MXI1chr10

112046160

-MXI1chr10

111985928

+
intron-intronENST00000369612ENST00000485566MXI1chr10

112046160

-MXI1chr10

111985928

+
intron-intronENST00000393134ENST00000332674MXI1chr10

112046160

-MXI1chr10

111985928

+
intron-intronENST00000393134ENST00000361248MXI1chr10

112046160

-MXI1chr10

111985928

+
intron-intronENST00000393134ENST00000369612MXI1chr10

112046160

-MXI1chr10

111985928

+
intron-intronENST00000393134ENST00000485566MXI1chr10

112046160

-MXI1chr10

111985928

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MXI1-MXI1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MXI1-MXI1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:112046160/:111985928)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MXI1

P50539

MXI1

P50539

FUNCTION: Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.FUNCTION: Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MXI1-MXI1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MXI1-MXI1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MXI1-MXI1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MXI1-MXI1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource