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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MYADM-TLK2 (FusionGDB2 ID:56160)

Fusion Gene Summary for MYADM-TLK2

check button Fusion gene summary
Fusion gene informationFusion gene name: MYADM-TLK2
Fusion gene ID: 56160
HgeneTgene
Gene symbol

MYADM

TLK2

Gene ID

91663

11011

Gene namemyeloid associated differentiation markertousled like kinase 2
SynonymsSB135HsHPK|MRD57|PKU-ALPHA
Cytomap

19q13.42

17q23.2

Type of geneprotein-codingprotein-coding
Descriptionmyeloid-associated differentiation markermyeloid upregulated proteinserine/threonine-protein kinase tousled-like 2
Modification date2020031320200313
UniProtAcc

Q96S97

.
Ensembl transtripts involved in fusion geneENST00000336967, ENST00000391769, 
ENST00000391770, ENST00000391771, 
ENST00000391768, 		ENST00000326270, 
ENST00000343388, ENST00000346027, 
ENST00000542523, ENST00000577616, 
ENST00000582809, 
Fusion gene scores* DoF score2 X 3 X 1=611 X 12 X 3=396
# samples 313
** MAII scorelog2(3/6*10)=2.32192809488736log2(13/396*10)=-1.60698880705116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYADM [Title/Abstract] AND TLK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYADM(54378586)-TLK2(60627211), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYADM

GO:0034115

negative regulation of heterotypic cell-cell adhesion

23264465

TgeneTLK2

GO:0001672

regulation of chromatin assembly or disassembly

12660173

TgeneTLK2

GO:0006468

protein phosphorylation

12660173

TgeneTLK2

GO:0006974

cellular response to DNA damage stimulus

12660173

TgeneTLK2

GO:0018105

peptidyl-serine phosphorylation

20016786

TgeneTLK2

GO:0035556

intracellular signal transduction

12660173

TgeneTLK2

GO:0071480

cellular response to gamma radiation

12660173


check buttonFusion gene breakpoints across MYADM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TLK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF339923MYADMchr19

54378586

+TLK2chr17

60627211

-


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Fusion Gene ORF analysis for MYADM-TLK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000336967ENST00000326270MYADMchr19

54378586

+TLK2chr17

60627211

-
3UTR-intronENST00000336967ENST00000343388MYADMchr19

54378586

+TLK2chr17

60627211

-
3UTR-intronENST00000336967ENST00000346027MYADMchr19

54378586

+TLK2chr17

60627211

-
3UTR-intronENST00000336967ENST00000542523MYADMchr19

54378586

+TLK2chr17

60627211

-
3UTR-intronENST00000336967ENST00000577616MYADMchr19

54378586

+TLK2chr17

60627211

-
3UTR-intronENST00000336967ENST00000582809MYADMchr19

54378586

+TLK2chr17

60627211

-
3UTR-intronENST00000391769ENST00000326270MYADMchr19

54378586

+TLK2chr17

60627211

-
3UTR-intronENST00000391769ENST00000343388MYADMchr19

54378586

+TLK2chr17

60627211

-
3UTR-intronENST00000391769ENST00000346027MYADMchr19

54378586

+TLK2chr17

60627211

-
3UTR-intronENST00000391769ENST00000542523MYADMchr19

54378586

+TLK2chr17

60627211

-
3UTR-intronENST00000391769ENST00000577616MYADMchr19

54378586

+TLK2chr17

60627211

-
3UTR-intronENST00000391769ENST00000582809MYADMchr19

54378586

+TLK2chr17

60627211

-
3UTR-intronENST00000391770ENST00000326270MYADMchr19

54378586

+TLK2chr17

60627211

-
3UTR-intronENST00000391770ENST00000343388MYADMchr19

54378586

+TLK2chr17

60627211

-
3UTR-intronENST00000391770ENST00000346027MYADMchr19

54378586

+TLK2chr17

60627211

-
3UTR-intronENST00000391770ENST00000542523MYADMchr19

54378586

+TLK2chr17

60627211

-
3UTR-intronENST00000391770ENST00000577616MYADMchr19

54378586

+TLK2chr17

60627211

-
3UTR-intronENST00000391770ENST00000582809MYADMchr19

54378586

+TLK2chr17

60627211

-
3UTR-intronENST00000391771ENST00000326270MYADMchr19

54378586

+TLK2chr17

60627211

-
3UTR-intronENST00000391771ENST00000343388MYADMchr19

54378586

+TLK2chr17

60627211

-
3UTR-intronENST00000391771ENST00000346027MYADMchr19

54378586

+TLK2chr17

60627211

-
3UTR-intronENST00000391771ENST00000542523MYADMchr19

54378586

+TLK2chr17

60627211

-
3UTR-intronENST00000391771ENST00000577616MYADMchr19

54378586

+TLK2chr17

60627211

-
3UTR-intronENST00000391771ENST00000582809MYADMchr19

54378586

+TLK2chr17

60627211

-
intron-intronENST00000391768ENST00000326270MYADMchr19

54378586

+TLK2chr17

60627211

-
intron-intronENST00000391768ENST00000343388MYADMchr19

54378586

+TLK2chr17

60627211

-
intron-intronENST00000391768ENST00000346027MYADMchr19

54378586

+TLK2chr17

60627211

-
intron-intronENST00000391768ENST00000542523MYADMchr19

54378586

+TLK2chr17

60627211

-
intron-intronENST00000391768ENST00000577616MYADMchr19

54378586

+TLK2chr17

60627211

-
intron-intronENST00000391768ENST00000582809MYADMchr19

54378586

+TLK2chr17

60627211

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MYADM-TLK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MYADM-TLK2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:54378586/:60627211)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYADM

Q96S97

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MYADM-TLK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MYADM-TLK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MYADM-TLK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MYADM-TLK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource