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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MYBL1-MMP16 (FusionGDB2 ID:56172)

Fusion Gene Summary for MYBL1-MMP16

check button Fusion gene summary
Fusion gene informationFusion gene name: MYBL1-MMP16
Fusion gene ID: 56172
HgeneTgene
Gene symbol

MYBL1

MMP16

Gene ID

4603

4325

Gene nameMYB proto-oncogene like 1matrix metallopeptidase 16
SynonymsA-MYB|AMYBC8orf57|MMP-X2|MT-MMP2|MT-MMP3|MT3-MMP
Cytomap

8q13.1

8q21.3

Type of geneprotein-codingprotein-coding
Descriptionmyb-related protein Amyb-like protein 1v-myb avian myeloblastosis viral oncogene homolog-like 1matrix metalloproteinase-16MMP-16MT-MMP 3MT3MMPMTMMP3Putative transmembrane protein C8orf57matrix metallopeptidase 16 (membrane-inserted)membrane-type matrix metalloproteinase 3membrane-type-3 matrix metalloproteinase
Modification date2020031320200313
UniProtAcc

P10243

P51512

Ensembl transtripts involved in fusion geneENST00000517885, ENST00000522677, 
ENST00000524176, ENST00000522419, 
ENST00000544227, ENST00000286614, 
Fusion gene scores* DoF score5 X 8 X 4=1604 X 3 X 3=36
# samples 44
** MAII scorelog2(4/160*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MYBL1 [Title/Abstract] AND MMP16 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYBL1(67484717)-MMP16(89086971), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYBL1

GO:0045944

positive regulation of transcription by RNA polymerase II

7987850

TgeneMMP16

GO:0006508

proteolysis

24970228

TgeneMMP16

GO:0016485

protein processing

27229514


check buttonFusion gene breakpoints across MYBL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MMP16 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A0TY-01AMYBL1chr8

67484717

-MMP16chr8

89086971

-


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Fusion Gene ORF analysis for MYBL1-MMP16

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000517885ENST00000544227MYBL1chr8

67484717

-MMP16chr8

89086971

-
5CDS-5UTRENST00000522677ENST00000544227MYBL1chr8

67484717

-MMP16chr8

89086971

-
5CDS-5UTRENST00000524176ENST00000544227MYBL1chr8

67484717

-MMP16chr8

89086971

-
In-frameENST00000517885ENST00000286614MYBL1chr8

67484717

-MMP16chr8

89086971

-
In-frameENST00000522677ENST00000286614MYBL1chr8

67484717

-MMP16chr8

89086971

-
In-frameENST00000524176ENST00000286614MYBL1chr8

67484717

-MMP16chr8

89086971

-
intron-3CDSENST00000522419ENST00000286614MYBL1chr8

67484717

-MMP16chr8

89086971

-
intron-5UTRENST00000522419ENST00000544227MYBL1chr8

67484717

-MMP16chr8

89086971

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000522677MYBL1chr867484717-ENST00000286614MMP16chr889086971-1233221394112879822
ENST00000517885MYBL1chr867484717-ENST00000286614MMP16chr889086971-1135111584561898480
ENST00000524176MYBL1chr867484717-ENST00000286614MMP16chr889086971-119901797692537822

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000522677ENST00000286614MYBL1chr867484717-MMP16chr889086971-0.0001514790.9998485
ENST00000517885ENST00000286614MYBL1chr867484717-MMP16chr889086971-0.0001127550.9998872
ENST00000524176ENST00000286614MYBL1chr867484717-MMP16chr889086971-0.0001456330.9998543

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Fusion Genomic Features for MYBL1-MMP16


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MYBL1-MMP16


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:67484717/chr8:89086971)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYBL1

P10243

MMP16

P51512

FUNCTION: Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' (PubMed:8058310, PubMed:7987850). Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity). Transcriptional activator of SOX30 (By similarity). {ECO:0000250|UniProtKB:P51960, ECO:0000269|PubMed:7987850, ECO:0000269|PubMed:8058310}.FUNCTION: Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells. {ECO:0000269|PubMed:11278606}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYBL1chr8:67484717chr8:89086971ENST00000522677-1216110_133576753.0DNA bindingH-T-H motif
HgeneMYBL1chr8:67484717chr8:89086971ENST00000522677-1216161_184576753.0DNA bindingH-T-H motif
HgeneMYBL1chr8:67484717chr8:89086971ENST00000522677-121658_81576753.0DNA bindingH-T-H motif
HgeneMYBL1chr8:67484717chr8:89086971ENST00000524176-1215110_133576693.0DNA bindingH-T-H motif
HgeneMYBL1chr8:67484717chr8:89086971ENST00000524176-1215161_184576693.0DNA bindingH-T-H motif
HgeneMYBL1chr8:67484717chr8:89086971ENST00000524176-121558_81576693.0DNA bindingH-T-H motif
HgeneMYBL1chr8:67484717chr8:89086971ENST00000522677-1216138_188576753.0DomainHTH myb-type 3
HgeneMYBL1chr8:67484717chr8:89086971ENST00000522677-121630_81576753.0DomainHTH myb-type 1
HgeneMYBL1chr8:67484717chr8:89086971ENST00000522677-121682_137576753.0DomainHTH myb-type 2
HgeneMYBL1chr8:67484717chr8:89086971ENST00000524176-1215138_188576693.0DomainHTH myb-type 3
HgeneMYBL1chr8:67484717chr8:89086971ENST00000524176-121530_81576693.0DomainHTH myb-type 1
HgeneMYBL1chr8:67484717chr8:89086971ENST00000524176-121582_137576693.0DomainHTH myb-type 2
HgeneMYBL1chr8:67484717chr8:89086971ENST00000522677-1216230_295576753.0RegionTranscriptional activation domain
HgeneMYBL1chr8:67484717chr8:89086971ENST00000522677-1216298_553576753.0RegionNegative regulatory domain
HgeneMYBL1chr8:67484717chr8:89086971ENST00000524176-1215230_295576693.0RegionTranscriptional activation domain
HgeneMYBL1chr8:67484717chr8:89086971ENST00000524176-1215298_553576693.0RegionNegative regulatory domain
TgeneMMP16chr8:67484717chr8:89086971ENST00000286614510389_434361608.0RepeatNote=Hemopexin 2
TgeneMMP16chr8:67484717chr8:89086971ENST00000286614510436_484361608.0RepeatNote=Hemopexin 3
TgeneMMP16chr8:67484717chr8:89086971ENST00000286614510485_532361608.0RepeatNote=Hemopexin 4
TgeneMMP16chr8:67484717chr8:89086971ENST00000286614510586_607361608.0Topological domainCytoplasmic
TgeneMMP16chr8:67484717chr8:89086971ENST00000286614510565_585361608.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMMP16chr8:67484717chr8:89086971ENST0000028661451099_106361608.0MotifCysteine switch
TgeneMMP16chr8:67484717chr8:89086971ENST00000286614510340_388361608.0RepeatNote=Hemopexin 1
TgeneMMP16chr8:67484717chr8:89086971ENST00000286614510120_564361608.0Topological domainExtracellular


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Fusion Gene Sequence for MYBL1-MMP16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>56172_56172_1_MYBL1-MMP16_MYBL1_chr8_67484717_ENST00000517885_MMP16_chr8_89086971_ENST00000286614_length(transcript)=11351nt_BP=1158nt
AAACGGCGGCTCTTGAGGGAGGCTGGGCGCGAGATTCGGCGGTGCGGACAAAACCCTGCAGGAGACTGCGAGCCCTGCAGAACTGCTAGC
TGCGGGGGAGAGGGCAGGGGTCGGGCGCCTGTGGCGGAGCCGGGCTGGGGCCAGGGCAGGGAGGCTGACAAGCGGCGGGAGAAGCCGGCG
GAGGGCGGGATCGCGCCTCCTGACATGTTGGGGGTATCCCTGGCCGGGCCGGGCCGGGGCTAAGAGCGGCGCTGCGGGCCGGGGTCGGGG
TCGGGTCGCGGTCCGCCCCCGCTGTCCCTCCGTCCTGCCCTGTCGAGGACGTGCGTTCCGCACTCGGCCGCCTCCAGAGGGAGCGAGGGA
AGCGGCTAGAGGATCGGGGAGAAGGAGCATTCGCCGGAGGCTGGAGGAGGCTGACCCGCGTCCCCGCCCAGCCTGCTCCTATGCGGTACT
TGAAGGATGGCGAAGAGGTCGCGCAGTGAGGATGAGGATGATGACCTTCAGTATGCCGATCATGATTATGAAGTACCACAACAAAAAGGA
CTGAAGAAACTCTGGAACAGAGTAAAATGGACAAGGGACGAGGATGATAAATTAAAGAAGTTGGTTGAACAACATGGAACTGATGATTGG
ACTCTAATTGCTAGTCATCTTCAAAATCGCTCTGATTTTCAGTGCCAGCATCGATGGCAGAAAGTTTTAAATCCTGAATTGATAAAGGGT
CCTTGGACTAAAGAAGAAGATCAGAGGGTTATTGAATTAGTTCAGAAATATGGAAAGAAGAGAAAAATGCGAGTGGGTCATTCCCCAGGC
AGCGAACTTAGGGATGGCTCATTGAACGATGGTGGTAATATGGCGCTAAAACATACACCACTGAAAACACTACCATTTTCTCCTTCACAG
TTTTTCAACACATGTCCTGGTAATGAACAACTTAATATAGAAAATCCTTCATTTACATCAACCCCTATTTGTGGGCAGAAAGCTCTCATT
ACAACTCCTCTTCATAAGGAAACAACTCCCAAAGATCAAAAGGAAAATGTAGGGTTTAGAACACCTACTATTAGAAGATCTATACTGGGT
ACCACACCAAGAACTCCTACTCCTTTTAAGAATGCGCTTGCTGCTCAGGAGAAAAAATATGGACCTCTTAAAATTGTGGACCAGTGGTTT
TGGCGAGTGAGAAACAACAGGGTGATGGATGGATACCCAATGCAAATTACTTACTTCTGGCGGGGCTTGCCTCCTAGTATCGATGCAGTT
TATGAAAATAGCGACGGGAATTTTGTGTTCTTTAAAGGTAACAAATATTGGGTGTTCAAGGATACAACTCTTCAACCTGGTTACCCTCAT
GACTTGATAACCCTTGGAAGTGGAATTCCCCCTCATGGTATTGATTCAGCCATTTGGTGGGAGGACGTCGGGAAAACCTATTTCTTCAAG
GGAGACAGATATTGGAGATATAGTGAAGAAATGAAAACAATGGACCCTGGCTATCCCAAGCCAATCACAGTCTGGAAAGGGATCCCTGAA
TCTCCTCAGGGAGCATTTGTACACAAAGAAAATGGCTTTACGTATTTCTACAAAGGAAAGGAGTATTGGAAATTCAACAACCAGATACTC
AAGGTAGAACCTGGATATCCAAGATCCATCCTCAAGGATTTTATGGGCTGTGATGGACCAACAGACAGAGTTAAAGAAGGACACAGCCCA
CCAGATGATGTAGACATTGTCATCAAACTGGACAACACAGCCAGCACTGTGAAAGCCATAGCTATTGTCATTCCCTGCATCTTGGCCTTA
TGCCTCCTTGTATTGGTTTACACTGTGTTCCAGTTCAAGAGGAAAGGAACACCCCGCCACATACTGTACTGTAAACGCTCTATGCAAGAG
TGGGTGTGATGTAGGGTTTTTTCTTCTTTCTTTCTTTTGCAGGAGTTTGTGGTAACTTGAGATTCAAGACAAGAGCTGTTATGCTGTTTC
CTAGCTAGGAGCAGGCTTGTGGCAGCCTGATTCGGGGCTGACCTTTCAAACCCAGAGGGTTGCTGGTCCTGCACATGAGTGGAAATACAC
TCATGGGGAAGCTTCCATGATGCACAGTATCTGCTGTTCTTCAGTCCTTTGTCTTTCTTTGTCATTCAGTTCTAGGCCTTTCCTCTGCAC
GCTCAATGCCCAGTAAAATTTCAGGATTAACTAAAGAAGAGGAGAAAAAGAAGAAAAGATTCTTCTTAAAAGTTTCTAATGTTATTTTCC
TTCTGAAGTCTGAGCCCATTTCTGGGGGGAGAAAAAAAAAGCAAATCAGAAAACCCACGGTTTTTCTTTTTTTCTTTTTTTCTTTTTTTC
TTTTTTTGCTTTAAAACAAAGGGAAAAAAGAGTTTAAACAAAAAACCCACAATTGAACTTCCAGGAAAGTGTGAAGACCCAAAACAGCTT
TGTCTCCAAAGAAGATAGCTCTCTGACTGCTTTGGATAGTCTCCTACGCACCATTTTGTCAGGTGGGAGATTTGGAATACACATGCAGGA
CGTTAGACTGTTGGGACAGCCATTTTCCAACAACCAAGGGGCCAAAATATCTGCAATATAGTAACAGCCTTAATAATACATCCATTTTTC
GTTTTATACAGCTGTTCTCAGCTATGTCCTCAGTGTTTCATCGCATTTATATTCATAGCTATTTTCAAACACGACCTTTTAATTGTTTTT
GAAGTATTTCTAAACCCCTTCTTTCCACCTTACTCCTCCATCATTGTGATAATCTTCCCAAGTTGTATTAGGCCATTGCCCCAGGCCTTC
CATGGGTCTGTCAGGAATATTCGTTACAAAGCAGAGCAAGAAGCAGTATGTCTCTGAAGTGGATTACAGTGGCAGTTATTTTACAAGGAT
TTGTGACACTAGTAACATACCCGTGTAACCCTTTGAGAACTATCAGACCAGCTTTCAGAGTCTTAGGATTGTCGGTCTTGCGATCTGATA
AATTATAGAACTGGGCAATGGTAAAAACAGTCACAAGTTCAAGAAGTTCAGGTTTTTAAAACAGATATCCTATAATGTCATATAATTTTT
AAATGATTTACAAGACTACATAAATGTGTTTATAACAAACAGAAATGATGTTACTTGCCAAAATTTTTCTGGCAAATAAAAAAGGTATTT
TATTAAGATTCTCATAAATCTGAAATTTTATTTGAAAAACTGATAATAGCCTAAGTCTTCTTTTCTTTTTTTTAGGCATACTGAATTTCT
GTTTTAAAATCCATTGCATGAAAATTCAATTTGCCTTGGTATATGCAGTTAGCATTGCCATTTTAAAAATGAATTAAAACGGTGACTCTG
AAGTTGCATGAATATCCTCCAGTGCATTACCTATTGCATGTCCACCATAGTTCTCAAAGGGTTAGTGTGGCTTCTGGCATTTAGCCGTCC
ATTTGATCACTGACAGAGCCAAGAGACCACCAAAGCATTTCATTGTTGAGTGTAATTTGTCCTAACAGCAGTATTGTCATTTTCATGTGA
CCTGCAGAGCAGGTTTGTATCAATATTTTTTTCCTAGAGAAAAGTCAGCAACTGACAGACCTCTTTATTGATTTTTAGGAGCTGCTTCTT
GCAGTGAAAGGCTTTACAGCCACTGGGCTGTGAACTTATTAGAGATGGTCAGAATGAATGCACCCCATGAGTCAGACATTGGCTTTGTGT
GAAAGCCAGCTTTGAGGGGATTAGCTTTTGAAACAATGAACAGCTTGCCTTGAACTTGATTATTGATCTATTGACTGTCATTAACAACAA
CTTAAACATTGTCTTCTGTGAAAATTTTCCTTGAAGAGTCCTGTTCTATGTCTTTGCCCTTTGACCTTTAACTTGCAAACTGGCACAAAC
TGAAGGAAATCTGGTGTTGCTTCTCCATTGGATTAGTTGTTCTCTAAAACCTAGTAAGCATGAGCTGTTTCCTTAGAGTGGAGAGAGTGG
TGATGGCAGATCTGCAGATGGACACTTTGCTCTTTACATGCACACTCTGAAAATGCCCTATAGGTAGAAGTGAATTTTAATTTCATTTTA
ATATAATTTCAAGTCTAAATTCATCATTTTAGTACAAATTACAAAAACTATAGGAAAAAAAAAACCTCAAATACTTGAATGGCCAGTGTG
GCTTTTATATAAAGCAGGAATTTTATACTAGTAAAAATTTCTTACTCATTTGCTAATACACATTTCCAGATGATTTTTAATGAGTGTAGG
TATACATTCTTATTTGGAAATGGATAGTTTGGCTGCCTTGAATTTATATTTATACTCAACGTAGCATGAAAATTAGAATGCCTTTTGGTT
AAACTACATGTTTATGATTTGGTTGGGGAAAATATTTTATAATTGTGGGTGGCATGCTGCAAAGCCTTGCAGATTGTTATTTCTTACAAC
CTGAGCGTATATAGTATGAGCCTAAGAAAAAAGAAGAGTAAGAAAAGAAGAATGGCTTTACAGTAAAATATCATACAATGCAGACAATAT
TTTAAGAGGATATTGGAGATTATGTACGCAAGGGCCAAGAAAGCAAGAAATGAGAACCAGAGTCAGCCCTGTAGCTTTACTTCAGTGCTT
CCATTCTAGATGATGCTGATATTATAAAGAGTTAGTCACTGCTGCTAAGCATGGAGGACTATATACATAAGCTCGTTTATACAGTGTTTG
CTTGTGGGAGGGTTTAATCCTTTTAGGGCCTTGATGTCAAGAAAAAAATAACTGGAAACTATATTTTGCTAAAGATAGAAATGAGGAACT
GTGTCATTTTGGGACATGTGCAAATCATTGAGGAACTCCATCACCCTGCATTGAAAATTGATTTTTTTTTCCTCTAAAATGAGAAAGAAA
CTGAATAAGCAATCTGTTGCCTCTTTACTCATTCATCACAATATCCTGATTCGTCATAAGGCTATCAGTATATAAGGGCTAGAAAATAAT
CATAGCATTAAGAAGGAAGGAGTCTATCATTATGCTTGAATTCTGGCAAATGTCATGAATAAGGGTTGGGTCATATTTACTTTAATATGA
GACAAGATTTATGTGATAAGCAAAGGCATATAAGGCTGCTCTTTTGAACAGAACATTTCAGTTATCAGGCTGTACTATTACAAGAGATAA
GAAGACAATAAGGACAATGTAATCACAAACAGTGGGATTCCATTTGTTTATTGTACACCAGCTACTTTGTGGGTATGGTTCCTGACTCCT
CTTCTACATGAGGTTTGGGAAAAAAGTCTCAAACCAAATGGAACAGTGAAAGGGAAAGTAATTCATCTAGCACATAAGAATAGTGATTCA
AAACCAATGCAGAATAAATTTCCATGGGTCAATAACATAAGGTGTCAGTTCAGTGTTACTAGAGATATGCAAGGCATAAAATATTTTCAT
CACCCCATCACTAATAACATGAAAAGCTCAGACATAGGATTTCCCAAATTGAAATGAAAACACATTCATGCCTGCAAAAATAATTCTCCT
TCTGCTTCATTTCTCATTACTTTATCTAATATAAACACAAATGTAAACAAGGTAATGGTCTTCATGTAAAATGACCATATAGTTAAGAAT
TTTAGTAAAATATTGTTGTTCTGTGTATTATTAAACAAATGCAATGAAGTATTAAAATAGCTGATCAGTTTGAATTTCCTGTAAAGCAGT
AATTCCGCATCAGAATTGTAGATAAGGTTGTGAATTTATTGACTCATTTCAGAACAGTGTCTGTTGACATGGCAGTCAGAGCAGGTGAAT
ACAGATGCTCTTTCTGATTGCAAAGGTTATAGAGCTAAATTAGACAGCATTATGTGATACTAGCAAAGACAACTTCTGTTATAAATCAGA
GGGCAAGGCTTTTCTGAATCGATGTGATAAATTACTAAGTAATGATTACCAAAAATAATTACTAAGTAATAAAAGATACAGACTGGTTTA
CTGAAATAAGCAAGTGTTACATTTAATAATTACCTATAATCTTTTTTTGTTAACACATAAGCAAGTGTTACCTTTAATAATTACCTATAA
TCTTTTTTTGTTAACACATAATTTGGCCATTTCATATACTGTGTACCTATTTTCATTCCCTCTCTGTGGGTCATTAAAAAACACAATGTG
GTGGATAAGAACATTGTCCAAACTTCACTGCTAGTTCCAATACATAGATGATGGTGTGTAAACTGGATTGTAGGGGTAGTCATATTTGCA
AGTTCTACATGTTATGCTAATATATCTAGTATGGTACACATACACGCCCACACTTTGTGGATCTTACAGTGGAATAAATAGTGTGTCCAT
ATTAACTAAACTCAAAGTGCTATCTGAAGAGGAATGGATGTTATAAGCAGACAGACAGACTGAGTTAAACTGAGTCATGAAAAAATATAT
ATTTTAAAGTTTTTGGAATCATTTCCAGAAACTAATAAAGGGAATTATTTACTGGTAGTATTGAGTCTGTGAGATTGTAGTATATACTGA
AACAATCTTCTGGATGGTGGTAAGGTCTTTTTTAGCAAACACAGTAAAGAGCTTATTTCATTTCTGATGCTTTCAAGGGCATATTCCAAA
GTATCACAGATGTCAAATAGAATATGCTATATAAACCAAAAATGTGCATTTCAGATGACCTATTACAGCAATCTCAGCCAATATGTAATA
TCACAAAATGTGTCAAGTCAATCATATAAGAGGATCTAATCATTCGGCTGTATTTCATGTACCTTCATGTTGTTGATATATTGTGACCAC
AGGAAATAGGTGCCAGAGCATATGCAGTTAAGTTACAGGCTCCACGTTGCCTAGGAGGGAATCATAACTACATCAGAAAATTTTTAACAG
TTATATCTTAAAAATTAGAATTTTATGTAATAAATAAAGCGGCAACCAGGAATAGCAACGCAACAAATATGAAAGCTAATTATTATATTT
AGCTTTCATATTTATATAATATGATGGAAATGGAGGAGGAAAAATGAGTCTTTTGTTAAATATAAAGACAAACTATAACACTCCTTGATA
ATACAACTGGAAATTTTACTTTAGCAAGCATAAAATAGTGGAGGAAAAAAATCCAACTTCAAGCTCTTTGCACTAGTGATGATTATGTGA
TATATCAATGTAATATTTAGCCAGTGGTCATTAGATGTTACTGTGCTTAAACACATCTGATACTCATGCATTGCCTTACAGGCTAAAAAT
GTAAGAGGTAGGTGTTCAGTAACCTCAAGTTGGAAAGATATATAATGTTAGAATCCCCTGAGACAAGCCATTTCCCTGAAATAGAAATTT
ACCTCAATACTCATGTAATCTAAGACACTTGGCGTAGTAGCAAAGAAGTTGCCTTCATGTTCTAGTCTCATCTAATTGTGACCTTTGTCT
TTCATGTACTTCTGAAATCATTTTCCACTTTTTCCACTGGTGTGATTTTGAAACAATTCTGAAATATTTCAGGTAAGATTAATAACATCC
AATTACAAATATATGTTTCAATATTTTATACGTATGTCTACTTTGAAAGTTAAACCAATAGTATAGAAAGCCTAAGAATGAACACTGATT
GGACATACTCACAGAAATTAAGGGAAAAACACATATTGTAAAATTCCTGTCAATGTTTGAGTAGAATACAGAAGTACATAGCAGTCTTCA
ATTTTTAAACACAATTATGGGCTTATAACTGGACGTGACATGCATCATTTATTAGAACAATATTATTTATTTATACTAAGTAAGGATATA
AGATCACAGAAGCTTAGTGTTATAACGGAGACTTCACAGACATTCATAACTAATGTTTTCTAAGGCAAATAAGGGCATAAACCAGAACTC
ATGGTCAGTGCAGAGTAAGTATAAAAAGTTATGTATGAAAGACATTTATTTATAGAGATTTCTGAGGATTCTATGCCTTTTCAACTTAAA
GATGAGTGTGTCTTAGAATTTGTTTTATGCATCATTGGACTGGGGATGATATTCAAATGTGCACTCAGCGTGTCCTCACATTAAAGGGCA
CATTGAACAGTATAGGAAAATACATCATAAACTAGAATGTTGTACAGATTCATATAACTTTCCCATGTGCTCTGCTGTAGAGCTGAATTT
ATATGCCCTTAAAAAGGGATAAGAATCAATTAAATATAAATACGGAAATATACTTATGTTAGGTCACTTAGCTTCAGAGCAAGATGTCAT
TAACCTTTATTTCACAGAGAAAAACTGGAAGAAAAGAATGGTGAACAAGAATAAAATGATAAACTTTTTGGCTTATAGAGATGTTTCTTG
GGAATTTTTTCCACTTGTTTTTATACATGAAAAAAATATCAGTCACAATACAGACATTTCTGTAGTATTTGGTCTGTGGGTAAACTGGAT
CCCAGGCAGAATACTTTTTGACACAGGCCTTTTTATACATGCTTTATATATGATGAAGCTTTGGTGAGATGTGACTGCATGGTAGGATGC
ATTTTCCTAGGATAGGATATGGTGCTGCTTGTACTTGCCACCTTTTATATGAATGTATGTCGCTACATTGGCCTGTCTTGCCAAGACATG
GTTGAATGAAGCCTGGTGTGAGCTGTCTATTTGAAAAGTCACTAGGATGCATGTTTCATTTGCCGTTACATAATGCCAATTTGAACCTGT
TTCCTCTATATATTAACAATCCAATTGTTAAGATAAAATATACTTTGCTTGAATGAATGATTTTGGTAGTAATATGAGCGTTATCCTTAA
ATCAATGTTACAATTTTTGCTATTACTGAAATACCGTCACAGAGGCCACATTATTGGCTGTCTATACCATTGCCTGAGTAAAATTAGGTT
TTTAGGTCTTTTTGGCATTTACTTCTTTTACAGCTGATGTGGAATCAATTATTCCTTTATATGTTCATAAGTACAAAATTTCACTATCTT
AATTACTTCCAAACAAACAATTTCCAAGCAAGGGTATGTGTGCCTGGTTTTTCTGCTCCTCCAATTCTAAGATCGTTATTTGTTTGCCTT
CTGTTTCTCACCCAAAAATACAGATGGTTGGGAAAGATACATCTTATTGAGTTGTCCTATGCAGTCTCTGTCTATATTTGCATTTCTTTC
TATTCCTATCTTGCCTTTTTTTTTTTTTTTTACACAGATTTGGTTTTCCCTTCCCTTTGTGAAAACCAGAATTGAGCAGCATTGTACATC
AGAGATGGTACCCAGGAAATGTCTTTGTTCCTCAGTATTTTTCGTCAAAACTTCCATGCAAAGACAGTCCCAGCAAAGTTGACATACATC
CCAACCTCTCTCATTGGCTTTTCTAACTTTTTATAGAGCTATTCCCCTGAGAAAAGTGAAATGCTGAGTATGATGGGTATTGCCTGTTGA
TAGGATAGCTAAGGAAATTTGCTTTTGGAGAATGTATCTTAAATAATTATACAGGAAAGTAGTCACAGTATAGTGTTCTGTTTAAGGTAC
ATCATGGGTACATAAATGCCTAAAACCTTCATCCTTTGGTCTATTTCTCTGTAAGTGTAAATTACATATATATTAGAAAGAGAGATAGAA
TCAAAGAATTAGGGGTGTTACAGAGGCAGCTTTTTGCTGCCTTGGTTTTGACTGTATCAGCATTTCTATTGCAGACCTCTATTTTCAGGG
GTTTTAGAGACTCGACCATAAAAATTTGTTTCAGGCTTAAAAGTTTTGAAAGATTTTTTTAGGTATCTGATTTTAAACAAATAGATCTTG
TTTTTATATTATAGGAGGGAAATAAATGGAGTTTACTAGTTCAATTTTGCGCTAATATAACTTTTAATAAACTTAACTTTTTAAACAAAA
ACATAAAATCTAATTAGTTCATAGTTGGTTGATGCTTTTTTAAAAGAATCAATTATTGACCTTGAGAAACTTGCCTGCTTCATCAGTATA
GTAACCTATCTTTAAGATATTTTAAAACGTGTATACCTTTATTAACATTATCTTGATTCCAGCGGTGGATCAGTATGATAATGCAGATTT
ATGACATCCATATAAGCTATCTGGTAATATAGATTTAGGAATATATAGTATATATGATACATATATATATATATATTTACTAGATAGATT
AAGGAGAAAAAGCTCCCATAAACTTAGTTTGTCAAATAAATACCATATATTTAAAAAATGCACAGACATTTATCATTCAGAGTCAGAATG
AGATTCAAGTAATTGCAAAGGGAAGTTGTCTCTTGGGTAAACAATACACATTTTATAGCTTCTTGTGAAACTAATTTTTTCCTTTCTATA
TTGTGGTTATGGGAAAGTAAAAGAATTAAAATTAATACAGACTTTATTTAAATAACATTAAACTGTGAAGCAGAGAGAAACGCCAGGAAA
TTAAATATTTAGGCCATTATCTTGTGGTTGTCTGACAATACTTCACCTTTCTTTTAATTCCCCATGATGTTTTCAATTATGGAGAGAGTA
TTAAAATCTAGATTTAAGTTTCTGCATTGTTCTCATTACACTCAACACTATTTCATTAAGTTCTTGATAATATGTAGTCTTCTGTGTGCA
AGGAAAGAAATAAATAACACATTTATTTGCTGAATGAGTTTTAAGGTGTGCAAGTTGTAGTGATGTTTTTCCCACACAGGATTCTATACA
CTTATACCATCTTAAATCTGGCATTTTTTTTTTCAGATAGCTTCTACTGACAAACACAAAGCTTGTTTGTGTGCAAATATAAGGCTAAAT
AAATGGTGCTAAAGTGTATTATGACTGTCAGATAAAATCAGGCAAAATTTTGTGGTGCTTAAATTAATTTTTTCATTGATTTTATTGATC
AGTGCATTGAACAGTGTTTATTATTCACAAGTTGTCTTTTATTAGTAAATCAAGGCCTCATAGCACATTGTTAAATAAAGTGGTTGACTA
GTCTATGTAACAGCTCACCAAGCTACTATCTCTTTTAACTCCTTATAATGTTGCGTCATTAAAGGTCAAGGGGTCATGCTATTAATCTCA
TTGCTATAGACCATTAACATGACTGAACTTTTCCACAAAGTACTTATGTTTACAATGCTATAACCCTTTGACTGCTGCGGCAACCTTTAA
CCACACAAATGTCACAAGCTAGAATCATCAGCATGGTTCTTGCCATGGCAATCAAAGAGTTAAGGGCTGTGCAGTGATTTGTTTTGTATT
TATTAATTTATATTTATTTTGTTTCCATTCAAGGAGGGGATTAGGGGTGGGGCAGTTTTTGTCTGCTGTAAGTGTCTTAACCTAGGGAAG
GGTTAAATGGCTTTTTATACTATTGCATCTTCTGTATTTACCATCAATTCATTGTGTTGTAATTAAAAGAAACTGTCAATAAATAAGAGA

>56172_56172_1_MYBL1-MMP16_MYBL1_chr8_67484717_ENST00000517885_MMP16_chr8_89086971_ENST00000286614_length(amino acids)=480AA_BP=234
MAKRSRSEDEDDDLQYADHDYEVPQQKGLKKLWNRVKWTRDEDDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPW
TKEEDQRVIELVQKYGKKRKMRVGHSPGSELRDGSLNDGGNMALKHTPLKTLPFSPSQFFNTCPGNEQLNIENPSFTSTPICGQKALITT
PLHKETTPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAAQEKKYGPLKIVDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYE
NSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESP
QGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCL

--------------------------------------------------------------
>56172_56172_2_MYBL1-MMP16_MYBL1_chr8_67484717_ENST00000522677_MMP16_chr8_89086971_ENST00000286614_length(transcript)=12332nt_BP=2139nt
GGACAAAACCCTGCAGGAGACTGCGAGCCCTGCAGAACTGCTAGCTGCGGGGGAGAGGGCAGGGGTCGGGCGCCTGTGGCGGAGCCGGGC
TGGGGCCAGGGCAGGGAGGCTGACAAGCGGCGGGAGAAGCCGGCGGAGGGCGGGATCGCGCCTCCTGACATGTTGGGGGTATCCCTGGCC
GGGCCGGGCCGGGGCTAAGAGCGGCGCTGCGGGCCGGGGTCGGGGTCGGGTCGCGGTCCGCCCCCGCTGTCCCTCCGTCCTGCCCTGTCG
AGGACGTGCGTTCCGCACTCGGCCGCCTCCAGAGGGAGCGAGGGAAGCGGCTAGAGGATCGGGGAGAAGGAGCATTCGCCGGAGGCTGGA
GGAGGCTGACCCGCGTCCCCGCCCAGCCTGCTCCTATGCGGTACTTGAAGGATGGCGAAGAGGTCGCGCAGTGAGGATGAGGATGATGAC
CTTCAGTATGCCGATCATGATTATGAAGTACCACAACAAAAAGGACTGAAGAAACTCTGGAACAGAGTAAAATGGACAAGGGACGAGGAT
GATAAATTAAAGAAGTTGGTTGAACAACATGGAACTGATGATTGGACTCTAATTGCTAGTCATCTTCAAAATCGCTCTGATTTTCAGTGC
CAGCATCGATGGCAGAAAGTTTTAAATCCTGAATTGATAAAGGGTCCTTGGACTAAAGAAGAAGATCAGAGGGTTATTGAATTAGTTCAG
AAATATGGGCCAAAAAGATGGTCTTTAATTGCAAAACATTTAAAAGGAAGAATAGGCAAGCAGTGTAGAGAAAGATGGCATAATCATCTG
AATCCTGAGGTAAAGAAATCTTCCTGGACAGAAGAGGAGGACAGGATCATCTATGAAGCACATAAGCGGTTGGGAAATCGTTGGGCAGAA
ATTGCCAAACTACTTCCAGGAAGGACTGATAATTCTATCAAAAATCATTGGAATTCTACTATGCGAAGAAAAGTGGAACAGGAGGGCTAT
TTACAAGATGGAATAAAATCAGAACGATCTTCATCTAAACTTCAACACAAACCTTGTGCAGCTATGGATCATATGCAAACCCAGAATCAG
TTTTACATACCTGTTCAGATCCCTGGGTATCAGTATGTGTCACCTGAAGGCAATTGTATAGAACATGTTCAGCCTACTTCTGCCTTTATT
CAGCAACCCTTCATTGATGAAGATCCTGATAAGGAAAAGAAAATAAAGGAACTTGAGATGCTTCTTATGTCAGCTGAGAATGAAGTTAGA
AGAAAGCGAATTCCATCACAGCCTGGAAGTTTTTCTAGCTGGTCTGGTAGTTTCCTCATGGATGATAACATGTCTAATACTCTAAATAGC
CTTGACGAGCACACTAGTGAGTTTTACAGTATGGATGAAAATCAGCCTGTGTCTGCTCAGCAGAATTCACCCACAAAGTTCCTGGCCGTG
GAGGCAAACGCTGTGTTATCCTCTTTGCAGACCATCCCAGAATTTGCAGAGACTCTAGAACTTATTGAATCTGATCCTGTAGCATGGAGT
GACGTTACCAGTTTTGATATTTCTGATGCTGCTGCTTCTCCTATCAAATCCACCCCAGTTAAATTAATGAGAATTCAGCACAATGAAGGA
GCCATGGAATGCCAATTTAACGTCAGTCTTGTACTTGAAGGGAAAAAAAACACTTGTAATGGTGGCAACAGTGAAGCTGTTCCTTTAACA
TCCCCAAATATAGCCAAGTTTAGCACTCCACCAGCCATCCTCAGAAAGAAGAGAAAAATGCGAGTGGGTCATTCCCCAGGCAGCGAACTT
AGGGATGGCTCATTGAACGATGGTGGTAATATGGCGCTAAAACATACACCACTGAAAACACTACCATTTTCTCCTTCACAGTTTTTCAAC
ACATGTCCTGGTAATGAACAACTTAATATAGAAAATCCTTCATTTACATCAACCCCTATTTGTGGGCAGAAAGCTCTCATTACAACTCCT
CTTCATAAGGAAACAACTCCCAAAGATCAAAAGGAAAATGTAGGGTTTAGAACACCTACTATTAGAAGATCTATACTGGGTACCACACCA
AGAACTCCTACTCCTTTTAAGAATGCGCTTGCTGCTCAGGAGAAAAAATATGGACCTCTTAAAATTGTGGACCAGTGGTTTTGGCGAGTG
AGAAACAACAGGGTGATGGATGGATACCCAATGCAAATTACTTACTTCTGGCGGGGCTTGCCTCCTAGTATCGATGCAGTTTATGAAAAT
AGCGACGGGAATTTTGTGTTCTTTAAAGGTAACAAATATTGGGTGTTCAAGGATACAACTCTTCAACCTGGTTACCCTCATGACTTGATA
ACCCTTGGAAGTGGAATTCCCCCTCATGGTATTGATTCAGCCATTTGGTGGGAGGACGTCGGGAAAACCTATTTCTTCAAGGGAGACAGA
TATTGGAGATATAGTGAAGAAATGAAAACAATGGACCCTGGCTATCCCAAGCCAATCACAGTCTGGAAAGGGATCCCTGAATCTCCTCAG
GGAGCATTTGTACACAAAGAAAATGGCTTTACGTATTTCTACAAAGGAAAGGAGTATTGGAAATTCAACAACCAGATACTCAAGGTAGAA
CCTGGATATCCAAGATCCATCCTCAAGGATTTTATGGGCTGTGATGGACCAACAGACAGAGTTAAAGAAGGACACAGCCCACCAGATGAT
GTAGACATTGTCATCAAACTGGACAACACAGCCAGCACTGTGAAAGCCATAGCTATTGTCATTCCCTGCATCTTGGCCTTATGCCTCCTT
GTATTGGTTTACACTGTGTTCCAGTTCAAGAGGAAAGGAACACCCCGCCACATACTGTACTGTAAACGCTCTATGCAAGAGTGGGTGTGA
TGTAGGGTTTTTTCTTCTTTCTTTCTTTTGCAGGAGTTTGTGGTAACTTGAGATTCAAGACAAGAGCTGTTATGCTGTTTCCTAGCTAGG
AGCAGGCTTGTGGCAGCCTGATTCGGGGCTGACCTTTCAAACCCAGAGGGTTGCTGGTCCTGCACATGAGTGGAAATACACTCATGGGGA
AGCTTCCATGATGCACAGTATCTGCTGTTCTTCAGTCCTTTGTCTTTCTTTGTCATTCAGTTCTAGGCCTTTCCTCTGCACGCTCAATGC
CCAGTAAAATTTCAGGATTAACTAAAGAAGAGGAGAAAAAGAAGAAAAGATTCTTCTTAAAAGTTTCTAATGTTATTTTCCTTCTGAAGT
CTGAGCCCATTTCTGGGGGGAGAAAAAAAAAGCAAATCAGAAAACCCACGGTTTTTCTTTTTTTCTTTTTTTCTTTTTTTCTTTTTTTGC
TTTAAAACAAAGGGAAAAAAGAGTTTAAACAAAAAACCCACAATTGAACTTCCAGGAAAGTGTGAAGACCCAAAACAGCTTTGTCTCCAA
AGAAGATAGCTCTCTGACTGCTTTGGATAGTCTCCTACGCACCATTTTGTCAGGTGGGAGATTTGGAATACACATGCAGGACGTTAGACT
GTTGGGACAGCCATTTTCCAACAACCAAGGGGCCAAAATATCTGCAATATAGTAACAGCCTTAATAATACATCCATTTTTCGTTTTATAC
AGCTGTTCTCAGCTATGTCCTCAGTGTTTCATCGCATTTATATTCATAGCTATTTTCAAACACGACCTTTTAATTGTTTTTGAAGTATTT
CTAAACCCCTTCTTTCCACCTTACTCCTCCATCATTGTGATAATCTTCCCAAGTTGTATTAGGCCATTGCCCCAGGCCTTCCATGGGTCT
GTCAGGAATATTCGTTACAAAGCAGAGCAAGAAGCAGTATGTCTCTGAAGTGGATTACAGTGGCAGTTATTTTACAAGGATTTGTGACAC
TAGTAACATACCCGTGTAACCCTTTGAGAACTATCAGACCAGCTTTCAGAGTCTTAGGATTGTCGGTCTTGCGATCTGATAAATTATAGA
ACTGGGCAATGGTAAAAACAGTCACAAGTTCAAGAAGTTCAGGTTTTTAAAACAGATATCCTATAATGTCATATAATTTTTAAATGATTT
ACAAGACTACATAAATGTGTTTATAACAAACAGAAATGATGTTACTTGCCAAAATTTTTCTGGCAAATAAAAAAGGTATTTTATTAAGAT
TCTCATAAATCTGAAATTTTATTTGAAAAACTGATAATAGCCTAAGTCTTCTTTTCTTTTTTTTAGGCATACTGAATTTCTGTTTTAAAA
TCCATTGCATGAAAATTCAATTTGCCTTGGTATATGCAGTTAGCATTGCCATTTTAAAAATGAATTAAAACGGTGACTCTGAAGTTGCAT
GAATATCCTCCAGTGCATTACCTATTGCATGTCCACCATAGTTCTCAAAGGGTTAGTGTGGCTTCTGGCATTTAGCCGTCCATTTGATCA
CTGACAGAGCCAAGAGACCACCAAAGCATTTCATTGTTGAGTGTAATTTGTCCTAACAGCAGTATTGTCATTTTCATGTGACCTGCAGAG
CAGGTTTGTATCAATATTTTTTTCCTAGAGAAAAGTCAGCAACTGACAGACCTCTTTATTGATTTTTAGGAGCTGCTTCTTGCAGTGAAA
GGCTTTACAGCCACTGGGCTGTGAACTTATTAGAGATGGTCAGAATGAATGCACCCCATGAGTCAGACATTGGCTTTGTGTGAAAGCCAG
CTTTGAGGGGATTAGCTTTTGAAACAATGAACAGCTTGCCTTGAACTTGATTATTGATCTATTGACTGTCATTAACAACAACTTAAACAT
TGTCTTCTGTGAAAATTTTCCTTGAAGAGTCCTGTTCTATGTCTTTGCCCTTTGACCTTTAACTTGCAAACTGGCACAAACTGAAGGAAA
TCTGGTGTTGCTTCTCCATTGGATTAGTTGTTCTCTAAAACCTAGTAAGCATGAGCTGTTTCCTTAGAGTGGAGAGAGTGGTGATGGCAG
ATCTGCAGATGGACACTTTGCTCTTTACATGCACACTCTGAAAATGCCCTATAGGTAGAAGTGAATTTTAATTTCATTTTAATATAATTT
CAAGTCTAAATTCATCATTTTAGTACAAATTACAAAAACTATAGGAAAAAAAAAACCTCAAATACTTGAATGGCCAGTGTGGCTTTTATA
TAAAGCAGGAATTTTATACTAGTAAAAATTTCTTACTCATTTGCTAATACACATTTCCAGATGATTTTTAATGAGTGTAGGTATACATTC
TTATTTGGAAATGGATAGTTTGGCTGCCTTGAATTTATATTTATACTCAACGTAGCATGAAAATTAGAATGCCTTTTGGTTAAACTACAT
GTTTATGATTTGGTTGGGGAAAATATTTTATAATTGTGGGTGGCATGCTGCAAAGCCTTGCAGATTGTTATTTCTTACAACCTGAGCGTA
TATAGTATGAGCCTAAGAAAAAAGAAGAGTAAGAAAAGAAGAATGGCTTTACAGTAAAATATCATACAATGCAGACAATATTTTAAGAGG
ATATTGGAGATTATGTACGCAAGGGCCAAGAAAGCAAGAAATGAGAACCAGAGTCAGCCCTGTAGCTTTACTTCAGTGCTTCCATTCTAG
ATGATGCTGATATTATAAAGAGTTAGTCACTGCTGCTAAGCATGGAGGACTATATACATAAGCTCGTTTATACAGTGTTTGCTTGTGGGA
GGGTTTAATCCTTTTAGGGCCTTGATGTCAAGAAAAAAATAACTGGAAACTATATTTTGCTAAAGATAGAAATGAGGAACTGTGTCATTT
TGGGACATGTGCAAATCATTGAGGAACTCCATCACCCTGCATTGAAAATTGATTTTTTTTTCCTCTAAAATGAGAAAGAAACTGAATAAG
CAATCTGTTGCCTCTTTACTCATTCATCACAATATCCTGATTCGTCATAAGGCTATCAGTATATAAGGGCTAGAAAATAATCATAGCATT
AAGAAGGAAGGAGTCTATCATTATGCTTGAATTCTGGCAAATGTCATGAATAAGGGTTGGGTCATATTTACTTTAATATGAGACAAGATT
TATGTGATAAGCAAAGGCATATAAGGCTGCTCTTTTGAACAGAACATTTCAGTTATCAGGCTGTACTATTACAAGAGATAAGAAGACAAT
AAGGACAATGTAATCACAAACAGTGGGATTCCATTTGTTTATTGTACACCAGCTACTTTGTGGGTATGGTTCCTGACTCCTCTTCTACAT
GAGGTTTGGGAAAAAAGTCTCAAACCAAATGGAACAGTGAAAGGGAAAGTAATTCATCTAGCACATAAGAATAGTGATTCAAAACCAATG
CAGAATAAATTTCCATGGGTCAATAACATAAGGTGTCAGTTCAGTGTTACTAGAGATATGCAAGGCATAAAATATTTTCATCACCCCATC
ACTAATAACATGAAAAGCTCAGACATAGGATTTCCCAAATTGAAATGAAAACACATTCATGCCTGCAAAAATAATTCTCCTTCTGCTTCA
TTTCTCATTACTTTATCTAATATAAACACAAATGTAAACAAGGTAATGGTCTTCATGTAAAATGACCATATAGTTAAGAATTTTAGTAAA
ATATTGTTGTTCTGTGTATTATTAAACAAATGCAATGAAGTATTAAAATAGCTGATCAGTTTGAATTTCCTGTAAAGCAGTAATTCCGCA
TCAGAATTGTAGATAAGGTTGTGAATTTATTGACTCATTTCAGAACAGTGTCTGTTGACATGGCAGTCAGAGCAGGTGAATACAGATGCT
CTTTCTGATTGCAAAGGTTATAGAGCTAAATTAGACAGCATTATGTGATACTAGCAAAGACAACTTCTGTTATAAATCAGAGGGCAAGGC
TTTTCTGAATCGATGTGATAAATTACTAAGTAATGATTACCAAAAATAATTACTAAGTAATAAAAGATACAGACTGGTTTACTGAAATAA
GCAAGTGTTACATTTAATAATTACCTATAATCTTTTTTTGTTAACACATAAGCAAGTGTTACCTTTAATAATTACCTATAATCTTTTTTT
GTTAACACATAATTTGGCCATTTCATATACTGTGTACCTATTTTCATTCCCTCTCTGTGGGTCATTAAAAAACACAATGTGGTGGATAAG
AACATTGTCCAAACTTCACTGCTAGTTCCAATACATAGATGATGGTGTGTAAACTGGATTGTAGGGGTAGTCATATTTGCAAGTTCTACA
TGTTATGCTAATATATCTAGTATGGTACACATACACGCCCACACTTTGTGGATCTTACAGTGGAATAAATAGTGTGTCCATATTAACTAA
ACTCAAAGTGCTATCTGAAGAGGAATGGATGTTATAAGCAGACAGACAGACTGAGTTAAACTGAGTCATGAAAAAATATATATTTTAAAG
TTTTTGGAATCATTTCCAGAAACTAATAAAGGGAATTATTTACTGGTAGTATTGAGTCTGTGAGATTGTAGTATATACTGAAACAATCTT
CTGGATGGTGGTAAGGTCTTTTTTAGCAAACACAGTAAAGAGCTTATTTCATTTCTGATGCTTTCAAGGGCATATTCCAAAGTATCACAG
ATGTCAAATAGAATATGCTATATAAACCAAAAATGTGCATTTCAGATGACCTATTACAGCAATCTCAGCCAATATGTAATATCACAAAAT
GTGTCAAGTCAATCATATAAGAGGATCTAATCATTCGGCTGTATTTCATGTACCTTCATGTTGTTGATATATTGTGACCACAGGAAATAG
GTGCCAGAGCATATGCAGTTAAGTTACAGGCTCCACGTTGCCTAGGAGGGAATCATAACTACATCAGAAAATTTTTAACAGTTATATCTT
AAAAATTAGAATTTTATGTAATAAATAAAGCGGCAACCAGGAATAGCAACGCAACAAATATGAAAGCTAATTATTATATTTAGCTTTCAT
ATTTATATAATATGATGGAAATGGAGGAGGAAAAATGAGTCTTTTGTTAAATATAAAGACAAACTATAACACTCCTTGATAATACAACTG
GAAATTTTACTTTAGCAAGCATAAAATAGTGGAGGAAAAAAATCCAACTTCAAGCTCTTTGCACTAGTGATGATTATGTGATATATCAAT
GTAATATTTAGCCAGTGGTCATTAGATGTTACTGTGCTTAAACACATCTGATACTCATGCATTGCCTTACAGGCTAAAAATGTAAGAGGT
AGGTGTTCAGTAACCTCAAGTTGGAAAGATATATAATGTTAGAATCCCCTGAGACAAGCCATTTCCCTGAAATAGAAATTTACCTCAATA
CTCATGTAATCTAAGACACTTGGCGTAGTAGCAAAGAAGTTGCCTTCATGTTCTAGTCTCATCTAATTGTGACCTTTGTCTTTCATGTAC
TTCTGAAATCATTTTCCACTTTTTCCACTGGTGTGATTTTGAAACAATTCTGAAATATTTCAGGTAAGATTAATAACATCCAATTACAAA
TATATGTTTCAATATTTTATACGTATGTCTACTTTGAAAGTTAAACCAATAGTATAGAAAGCCTAAGAATGAACACTGATTGGACATACT
CACAGAAATTAAGGGAAAAACACATATTGTAAAATTCCTGTCAATGTTTGAGTAGAATACAGAAGTACATAGCAGTCTTCAATTTTTAAA
CACAATTATGGGCTTATAACTGGACGTGACATGCATCATTTATTAGAACAATATTATTTATTTATACTAAGTAAGGATATAAGATCACAG
AAGCTTAGTGTTATAACGGAGACTTCACAGACATTCATAACTAATGTTTTCTAAGGCAAATAAGGGCATAAACCAGAACTCATGGTCAGT
GCAGAGTAAGTATAAAAAGTTATGTATGAAAGACATTTATTTATAGAGATTTCTGAGGATTCTATGCCTTTTCAACTTAAAGATGAGTGT
GTCTTAGAATTTGTTTTATGCATCATTGGACTGGGGATGATATTCAAATGTGCACTCAGCGTGTCCTCACATTAAAGGGCACATTGAACA
GTATAGGAAAATACATCATAAACTAGAATGTTGTACAGATTCATATAACTTTCCCATGTGCTCTGCTGTAGAGCTGAATTTATATGCCCT
TAAAAAGGGATAAGAATCAATTAAATATAAATACGGAAATATACTTATGTTAGGTCACTTAGCTTCAGAGCAAGATGTCATTAACCTTTA
TTTCACAGAGAAAAACTGGAAGAAAAGAATGGTGAACAAGAATAAAATGATAAACTTTTTGGCTTATAGAGATGTTTCTTGGGAATTTTT
TCCACTTGTTTTTATACATGAAAAAAATATCAGTCACAATACAGACATTTCTGTAGTATTTGGTCTGTGGGTAAACTGGATCCCAGGCAG
AATACTTTTTGACACAGGCCTTTTTATACATGCTTTATATATGATGAAGCTTTGGTGAGATGTGACTGCATGGTAGGATGCATTTTCCTA
GGATAGGATATGGTGCTGCTTGTACTTGCCACCTTTTATATGAATGTATGTCGCTACATTGGCCTGTCTTGCCAAGACATGGTTGAATGA
AGCCTGGTGTGAGCTGTCTATTTGAAAAGTCACTAGGATGCATGTTTCATTTGCCGTTACATAATGCCAATTTGAACCTGTTTCCTCTAT
ATATTAACAATCCAATTGTTAAGATAAAATATACTTTGCTTGAATGAATGATTTTGGTAGTAATATGAGCGTTATCCTTAAATCAATGTT
ACAATTTTTGCTATTACTGAAATACCGTCACAGAGGCCACATTATTGGCTGTCTATACCATTGCCTGAGTAAAATTAGGTTTTTAGGTCT
TTTTGGCATTTACTTCTTTTACAGCTGATGTGGAATCAATTATTCCTTTATATGTTCATAAGTACAAAATTTCACTATCTTAATTACTTC
CAAACAAACAATTTCCAAGCAAGGGTATGTGTGCCTGGTTTTTCTGCTCCTCCAATTCTAAGATCGTTATTTGTTTGCCTTCTGTTTCTC
ACCCAAAAATACAGATGGTTGGGAAAGATACATCTTATTGAGTTGTCCTATGCAGTCTCTGTCTATATTTGCATTTCTTTCTATTCCTAT
CTTGCCTTTTTTTTTTTTTTTTACACAGATTTGGTTTTCCCTTCCCTTTGTGAAAACCAGAATTGAGCAGCATTGTACATCAGAGATGGT
ACCCAGGAAATGTCTTTGTTCCTCAGTATTTTTCGTCAAAACTTCCATGCAAAGACAGTCCCAGCAAAGTTGACATACATCCCAACCTCT
CTCATTGGCTTTTCTAACTTTTTATAGAGCTATTCCCCTGAGAAAAGTGAAATGCTGAGTATGATGGGTATTGCCTGTTGATAGGATAGC
TAAGGAAATTTGCTTTTGGAGAATGTATCTTAAATAATTATACAGGAAAGTAGTCACAGTATAGTGTTCTGTTTAAGGTACATCATGGGT
ACATAAATGCCTAAAACCTTCATCCTTTGGTCTATTTCTCTGTAAGTGTAAATTACATATATATTAGAAAGAGAGATAGAATCAAAGAAT
TAGGGGTGTTACAGAGGCAGCTTTTTGCTGCCTTGGTTTTGACTGTATCAGCATTTCTATTGCAGACCTCTATTTTCAGGGGTTTTAGAG
ACTCGACCATAAAAATTTGTTTCAGGCTTAAAAGTTTTGAAAGATTTTTTTAGGTATCTGATTTTAAACAAATAGATCTTGTTTTTATAT
TATAGGAGGGAAATAAATGGAGTTTACTAGTTCAATTTTGCGCTAATATAACTTTTAATAAACTTAACTTTTTAAACAAAAACATAAAAT
CTAATTAGTTCATAGTTGGTTGATGCTTTTTTAAAAGAATCAATTATTGACCTTGAGAAACTTGCCTGCTTCATCAGTATAGTAACCTAT
CTTTAAGATATTTTAAAACGTGTATACCTTTATTAACATTATCTTGATTCCAGCGGTGGATCAGTATGATAATGCAGATTTATGACATCC
ATATAAGCTATCTGGTAATATAGATTTAGGAATATATAGTATATATGATACATATATATATATATATTTACTAGATAGATTAAGGAGAAA
AAGCTCCCATAAACTTAGTTTGTCAAATAAATACCATATATTTAAAAAATGCACAGACATTTATCATTCAGAGTCAGAATGAGATTCAAG
TAATTGCAAAGGGAAGTTGTCTCTTGGGTAAACAATACACATTTTATAGCTTCTTGTGAAACTAATTTTTTCCTTTCTATATTGTGGTTA
TGGGAAAGTAAAAGAATTAAAATTAATACAGACTTTATTTAAATAACATTAAACTGTGAAGCAGAGAGAAACGCCAGGAAATTAAATATT
TAGGCCATTATCTTGTGGTTGTCTGACAATACTTCACCTTTCTTTTAATTCCCCATGATGTTTTCAATTATGGAGAGAGTATTAAAATCT
AGATTTAAGTTTCTGCATTGTTCTCATTACACTCAACACTATTTCATTAAGTTCTTGATAATATGTAGTCTTCTGTGTGCAAGGAAAGAA
ATAAATAACACATTTATTTGCTGAATGAGTTTTAAGGTGTGCAAGTTGTAGTGATGTTTTTCCCACACAGGATTCTATACACTTATACCA
TCTTAAATCTGGCATTTTTTTTTTCAGATAGCTTCTACTGACAAACACAAAGCTTGTTTGTGTGCAAATATAAGGCTAAATAAATGGTGC
TAAAGTGTATTATGACTGTCAGATAAAATCAGGCAAAATTTTGTGGTGCTTAAATTAATTTTTTCATTGATTTTATTGATCAGTGCATTG
AACAGTGTTTATTATTCACAAGTTGTCTTTTATTAGTAAATCAAGGCCTCATAGCACATTGTTAAATAAAGTGGTTGACTAGTCTATGTA
ACAGCTCACCAAGCTACTATCTCTTTTAACTCCTTATAATGTTGCGTCATTAAAGGTCAAGGGGTCATGCTATTAATCTCATTGCTATAG
ACCATTAACATGACTGAACTTTTCCACAAAGTACTTATGTTTACAATGCTATAACCCTTTGACTGCTGCGGCAACCTTTAACCACACAAA
TGTCACAAGCTAGAATCATCAGCATGGTTCTTGCCATGGCAATCAAAGAGTTAAGGGCTGTGCAGTGATTTGTTTTGTATTTATTAATTT
ATATTTATTTTGTTTCCATTCAAGGAGGGGATTAGGGGTGGGGCAGTTTTTGTCTGCTGTAAGTGTCTTAACCTAGGGAAGGGTTAAATG
GCTTTTTATACTATTGCATCTTCTGTATTTACCATCAATTCATTGTGTTGTAATTAAAAGAAACTGTCAATAAATAAGAGAACAGAAAAA

>56172_56172_2_MYBL1-MMP16_MYBL1_chr8_67484717_ENST00000522677_MMP16_chr8_89086971_ENST00000286614_length(amino acids)=822AA_BP=576
MAKRSRSEDEDDDLQYADHDYEVPQQKGLKKLWNRVKWTRDEDDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPW
TKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRWAEIAKLLPGRTDNSIKNHW
NSTMRRKVEQEGYLQDGIKSERSSSKLQHKPCAAMDHMQTQNQFYIPVQIPGYQYVSPEGNCIEHVQPTSAFIQQPFIDEDPDKEKKIKE
LEMLLMSAENEVRRKRIPSQPGSFSSWSGSFLMDDNMSNTLNSLDEHTSEFYSMDENQPVSAQQNSPTKFLAVEANAVLSSLQTIPEFAE
TLELIESDPVAWSDVTSFDISDAAASPIKSTPVKLMRIQHNEGAMECQFNVSLVLEGKKNTCNGGNSEAVPLTSPNIAKFSTPPAILRKK
RKMRVGHSPGSELRDGSLNDGGNMALKHTPLKTLPFSPSQFFNTCPGNEQLNIENPSFTSTPICGQKALITTPLHKETTPKDQKENVGFR
TPTIRRSILGTTPRTPTPFKNALAAQEKKYGPLKIVDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFK
DTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGK
EYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRH

--------------------------------------------------------------
>56172_56172_3_MYBL1-MMP16_MYBL1_chr8_67484717_ENST00000524176_MMP16_chr8_89086971_ENST00000286614_length(transcript)=11990nt_BP=1797nt
CATTCGCCGGAGGCTGGAGGAGGCTGACCCGCGTCCCCGCCCAGCCTGCTCCTATGCGGTACTTGAAGGATGGCGAAGAGGTCGCGCAGT
GAGGATGAGGATGATGACCTTCAGTATGCCGATCATGATTATGAAGTACCACAACAAAAAGGACTGAAGAAACTCTGGAACAGAGTAAAA
TGGACAAGGGACGAGGATGATAAATTAAAGAAGTTGGTTGAACAACATGGAACTGATGATTGGACTCTAATTGCTAGTCATCTTCAAAAT
CGCTCTGATTTTCAGTGCCAGCATCGATGGCAGAAAGTTTTAAATCCTGAATTGATAAAGGGTCCTTGGACTAAAGAAGAAGATCAGAGG
GTTATTGAATTAGTTCAGAAATATGGGCCAAAAAGATGGTCTTTAATTGCAAAACATTTAAAAGGAAGAATAGGCAAGCAGTGTAGAGAA
AGATGGCATAATCATCTGAATCCTGAGGTAAAGAAATCTTCCTGGACAGAAGAGGAGGACAGGATCATCTATGAAGCACATAAGCGGTTG
GGAAATCGTTGGGCAGAAATTGCCAAACTACTTCCAGGAAGGACTGATAATTCTATCAAAAATCATTGGAATTCTACTATGCGAAGAAAA
GTGGAACAGGAGGGCTATTTACAAGATGGAATAAAATCAGAACGATCTTCATCTAAACTTCAACACAAACCTTGTGCAGCTATGGATCAT
ATGCAAACCCAGAATCAGTTTTACATACCTGTTCAGATCCCTGGGTATCAGTATGTGTCACCTGAAGGCAATTGTATAGAACATGTTCAG
CCTACTTCTGCCTTTATTCAGCAACCCTTCATTGATGAAGATCCTGATAAGGAAAAGAAAATAAAGGAACTTGAGATGCTTCTTATGTCA
GCTGAGAATGAAGTTAGAAGAAAGCGAATTCCATCACAGCCTGGAAGTTTTTCTAGCTGGTCTGGTAGTTTCCTCATGGATGATAACATG
TCTAATACTCTAAATAGCCTTGACGAGCACACTAGTGAGTTTTACAGTATGGATGAAAATCAGCCTGTGTCTGCTCAGCAGAATTCACCC
ACAAAGTTCCTGGCCGTGGAGGCAAACGCTGTGTTATCCTCTTTGCAGACCATCCCAGAATTTGCAGAGACTCTAGAACTTATTGAATCT
GATCCTGTAGCATGGAGTGACGTTACCAGTTTTGATATTTCTGATGCTGCTGCTTCTCCTATCAAATCCACCCCAGTTAAATTAATGAGA
ATTCAGCACAATGAAGGAGCCATGGAATGCCAATTTAACGTCAGTCTTGTACTTGAAGGGAAAAAAAACACTTGTAATGGTGGCAACAGT
GAAGCTGTTCCTTTAACATCCCCAAATATAGCCAAGTTTAGCACTCCACCAGCCATCCTCAGAAAGAAGAGAAAAATGCGAGTGGGTCAT
TCCCCAGGCAGCGAACTTAGGGATGGCTCATTGAACGATGGTGGTAATATGGCGCTAAAACATACACCACTGAAAACACTACCATTTTCT
CCTTCACAGTTTTTCAACACATGTCCTGGTAATGAACAACTTAATATAGAAAATCCTTCATTTACATCAACCCCTATTTGTGGGCAGAAA
GCTCTCATTACAACTCCTCTTCATAAGGAAACAACTCCCAAAGATCAAAAGGAAAATGTAGGGTTTAGAACACCTACTATTAGAAGATCT
ATACTGGGTACCACACCAAGAACTCCTACTCCTTTTAAGAATGCGCTTGCTGCTCAGGAGAAAAAATATGGACCTCTTAAAATTGTGGAC
CAGTGGTTTTGGCGAGTGAGAAACAACAGGGTGATGGATGGATACCCAATGCAAATTACTTACTTCTGGCGGGGCTTGCCTCCTAGTATC
GATGCAGTTTATGAAAATAGCGACGGGAATTTTGTGTTCTTTAAAGGTAACAAATATTGGGTGTTCAAGGATACAACTCTTCAACCTGGT
TACCCTCATGACTTGATAACCCTTGGAAGTGGAATTCCCCCTCATGGTATTGATTCAGCCATTTGGTGGGAGGACGTCGGGAAAACCTAT
TTCTTCAAGGGAGACAGATATTGGAGATATAGTGAAGAAATGAAAACAATGGACCCTGGCTATCCCAAGCCAATCACAGTCTGGAAAGGG
ATCCCTGAATCTCCTCAGGGAGCATTTGTACACAAAGAAAATGGCTTTACGTATTTCTACAAAGGAAAGGAGTATTGGAAATTCAACAAC
CAGATACTCAAGGTAGAACCTGGATATCCAAGATCCATCCTCAAGGATTTTATGGGCTGTGATGGACCAACAGACAGAGTTAAAGAAGGA
CACAGCCCACCAGATGATGTAGACATTGTCATCAAACTGGACAACACAGCCAGCACTGTGAAAGCCATAGCTATTGTCATTCCCTGCATC
TTGGCCTTATGCCTCCTTGTATTGGTTTACACTGTGTTCCAGTTCAAGAGGAAAGGAACACCCCGCCACATACTGTACTGTAAACGCTCT
ATGCAAGAGTGGGTGTGATGTAGGGTTTTTTCTTCTTTCTTTCTTTTGCAGGAGTTTGTGGTAACTTGAGATTCAAGACAAGAGCTGTTA
TGCTGTTTCCTAGCTAGGAGCAGGCTTGTGGCAGCCTGATTCGGGGCTGACCTTTCAAACCCAGAGGGTTGCTGGTCCTGCACATGAGTG
GAAATACACTCATGGGGAAGCTTCCATGATGCACAGTATCTGCTGTTCTTCAGTCCTTTGTCTTTCTTTGTCATTCAGTTCTAGGCCTTT
CCTCTGCACGCTCAATGCCCAGTAAAATTTCAGGATTAACTAAAGAAGAGGAGAAAAAGAAGAAAAGATTCTTCTTAAAAGTTTCTAATG
TTATTTTCCTTCTGAAGTCTGAGCCCATTTCTGGGGGGAGAAAAAAAAAGCAAATCAGAAAACCCACGGTTTTTCTTTTTTTCTTTTTTT
CTTTTTTTCTTTTTTTGCTTTAAAACAAAGGGAAAAAAGAGTTTAAACAAAAAACCCACAATTGAACTTCCAGGAAAGTGTGAAGACCCA
AAACAGCTTTGTCTCCAAAGAAGATAGCTCTCTGACTGCTTTGGATAGTCTCCTACGCACCATTTTGTCAGGTGGGAGATTTGGAATACA
CATGCAGGACGTTAGACTGTTGGGACAGCCATTTTCCAACAACCAAGGGGCCAAAATATCTGCAATATAGTAACAGCCTTAATAATACAT
CCATTTTTCGTTTTATACAGCTGTTCTCAGCTATGTCCTCAGTGTTTCATCGCATTTATATTCATAGCTATTTTCAAACACGACCTTTTA
ATTGTTTTTGAAGTATTTCTAAACCCCTTCTTTCCACCTTACTCCTCCATCATTGTGATAATCTTCCCAAGTTGTATTAGGCCATTGCCC
CAGGCCTTCCATGGGTCTGTCAGGAATATTCGTTACAAAGCAGAGCAAGAAGCAGTATGTCTCTGAAGTGGATTACAGTGGCAGTTATTT
TACAAGGATTTGTGACACTAGTAACATACCCGTGTAACCCTTTGAGAACTATCAGACCAGCTTTCAGAGTCTTAGGATTGTCGGTCTTGC
GATCTGATAAATTATAGAACTGGGCAATGGTAAAAACAGTCACAAGTTCAAGAAGTTCAGGTTTTTAAAACAGATATCCTATAATGTCAT
ATAATTTTTAAATGATTTACAAGACTACATAAATGTGTTTATAACAAACAGAAATGATGTTACTTGCCAAAATTTTTCTGGCAAATAAAA
AAGGTATTTTATTAAGATTCTCATAAATCTGAAATTTTATTTGAAAAACTGATAATAGCCTAAGTCTTCTTTTCTTTTTTTTAGGCATAC
TGAATTTCTGTTTTAAAATCCATTGCATGAAAATTCAATTTGCCTTGGTATATGCAGTTAGCATTGCCATTTTAAAAATGAATTAAAACG
GTGACTCTGAAGTTGCATGAATATCCTCCAGTGCATTACCTATTGCATGTCCACCATAGTTCTCAAAGGGTTAGTGTGGCTTCTGGCATT
TAGCCGTCCATTTGATCACTGACAGAGCCAAGAGACCACCAAAGCATTTCATTGTTGAGTGTAATTTGTCCTAACAGCAGTATTGTCATT
TTCATGTGACCTGCAGAGCAGGTTTGTATCAATATTTTTTTCCTAGAGAAAAGTCAGCAACTGACAGACCTCTTTATTGATTTTTAGGAG
CTGCTTCTTGCAGTGAAAGGCTTTACAGCCACTGGGCTGTGAACTTATTAGAGATGGTCAGAATGAATGCACCCCATGAGTCAGACATTG
GCTTTGTGTGAAAGCCAGCTTTGAGGGGATTAGCTTTTGAAACAATGAACAGCTTGCCTTGAACTTGATTATTGATCTATTGACTGTCAT
TAACAACAACTTAAACATTGTCTTCTGTGAAAATTTTCCTTGAAGAGTCCTGTTCTATGTCTTTGCCCTTTGACCTTTAACTTGCAAACT
GGCACAAACTGAAGGAAATCTGGTGTTGCTTCTCCATTGGATTAGTTGTTCTCTAAAACCTAGTAAGCATGAGCTGTTTCCTTAGAGTGG
AGAGAGTGGTGATGGCAGATCTGCAGATGGACACTTTGCTCTTTACATGCACACTCTGAAAATGCCCTATAGGTAGAAGTGAATTTTAAT
TTCATTTTAATATAATTTCAAGTCTAAATTCATCATTTTAGTACAAATTACAAAAACTATAGGAAAAAAAAAACCTCAAATACTTGAATG
GCCAGTGTGGCTTTTATATAAAGCAGGAATTTTATACTAGTAAAAATTTCTTACTCATTTGCTAATACACATTTCCAGATGATTTTTAAT
GAGTGTAGGTATACATTCTTATTTGGAAATGGATAGTTTGGCTGCCTTGAATTTATATTTATACTCAACGTAGCATGAAAATTAGAATGC
CTTTTGGTTAAACTACATGTTTATGATTTGGTTGGGGAAAATATTTTATAATTGTGGGTGGCATGCTGCAAAGCCTTGCAGATTGTTATT
TCTTACAACCTGAGCGTATATAGTATGAGCCTAAGAAAAAAGAAGAGTAAGAAAAGAAGAATGGCTTTACAGTAAAATATCATACAATGC
AGACAATATTTTAAGAGGATATTGGAGATTATGTACGCAAGGGCCAAGAAAGCAAGAAATGAGAACCAGAGTCAGCCCTGTAGCTTTACT
TCAGTGCTTCCATTCTAGATGATGCTGATATTATAAAGAGTTAGTCACTGCTGCTAAGCATGGAGGACTATATACATAAGCTCGTTTATA
CAGTGTTTGCTTGTGGGAGGGTTTAATCCTTTTAGGGCCTTGATGTCAAGAAAAAAATAACTGGAAACTATATTTTGCTAAAGATAGAAA
TGAGGAACTGTGTCATTTTGGGACATGTGCAAATCATTGAGGAACTCCATCACCCTGCATTGAAAATTGATTTTTTTTTCCTCTAAAATG
AGAAAGAAACTGAATAAGCAATCTGTTGCCTCTTTACTCATTCATCACAATATCCTGATTCGTCATAAGGCTATCAGTATATAAGGGCTA
GAAAATAATCATAGCATTAAGAAGGAAGGAGTCTATCATTATGCTTGAATTCTGGCAAATGTCATGAATAAGGGTTGGGTCATATTTACT
TTAATATGAGACAAGATTTATGTGATAAGCAAAGGCATATAAGGCTGCTCTTTTGAACAGAACATTTCAGTTATCAGGCTGTACTATTAC
AAGAGATAAGAAGACAATAAGGACAATGTAATCACAAACAGTGGGATTCCATTTGTTTATTGTACACCAGCTACTTTGTGGGTATGGTTC
CTGACTCCTCTTCTACATGAGGTTTGGGAAAAAAGTCTCAAACCAAATGGAACAGTGAAAGGGAAAGTAATTCATCTAGCACATAAGAAT
AGTGATTCAAAACCAATGCAGAATAAATTTCCATGGGTCAATAACATAAGGTGTCAGTTCAGTGTTACTAGAGATATGCAAGGCATAAAA
TATTTTCATCACCCCATCACTAATAACATGAAAAGCTCAGACATAGGATTTCCCAAATTGAAATGAAAACACATTCATGCCTGCAAAAAT
AATTCTCCTTCTGCTTCATTTCTCATTACTTTATCTAATATAAACACAAATGTAAACAAGGTAATGGTCTTCATGTAAAATGACCATATA
GTTAAGAATTTTAGTAAAATATTGTTGTTCTGTGTATTATTAAACAAATGCAATGAAGTATTAAAATAGCTGATCAGTTTGAATTTCCTG
TAAAGCAGTAATTCCGCATCAGAATTGTAGATAAGGTTGTGAATTTATTGACTCATTTCAGAACAGTGTCTGTTGACATGGCAGTCAGAG
CAGGTGAATACAGATGCTCTTTCTGATTGCAAAGGTTATAGAGCTAAATTAGACAGCATTATGTGATACTAGCAAAGACAACTTCTGTTA
TAAATCAGAGGGCAAGGCTTTTCTGAATCGATGTGATAAATTACTAAGTAATGATTACCAAAAATAATTACTAAGTAATAAAAGATACAG
ACTGGTTTACTGAAATAAGCAAGTGTTACATTTAATAATTACCTATAATCTTTTTTTGTTAACACATAAGCAAGTGTTACCTTTAATAAT
TACCTATAATCTTTTTTTGTTAACACATAATTTGGCCATTTCATATACTGTGTACCTATTTTCATTCCCTCTCTGTGGGTCATTAAAAAA
CACAATGTGGTGGATAAGAACATTGTCCAAACTTCACTGCTAGTTCCAATACATAGATGATGGTGTGTAAACTGGATTGTAGGGGTAGTC
ATATTTGCAAGTTCTACATGTTATGCTAATATATCTAGTATGGTACACATACACGCCCACACTTTGTGGATCTTACAGTGGAATAAATAG
TGTGTCCATATTAACTAAACTCAAAGTGCTATCTGAAGAGGAATGGATGTTATAAGCAGACAGACAGACTGAGTTAAACTGAGTCATGAA
AAAATATATATTTTAAAGTTTTTGGAATCATTTCCAGAAACTAATAAAGGGAATTATTTACTGGTAGTATTGAGTCTGTGAGATTGTAGT
ATATACTGAAACAATCTTCTGGATGGTGGTAAGGTCTTTTTTAGCAAACACAGTAAAGAGCTTATTTCATTTCTGATGCTTTCAAGGGCA
TATTCCAAAGTATCACAGATGTCAAATAGAATATGCTATATAAACCAAAAATGTGCATTTCAGATGACCTATTACAGCAATCTCAGCCAA
TATGTAATATCACAAAATGTGTCAAGTCAATCATATAAGAGGATCTAATCATTCGGCTGTATTTCATGTACCTTCATGTTGTTGATATAT
TGTGACCACAGGAAATAGGTGCCAGAGCATATGCAGTTAAGTTACAGGCTCCACGTTGCCTAGGAGGGAATCATAACTACATCAGAAAAT
TTTTAACAGTTATATCTTAAAAATTAGAATTTTATGTAATAAATAAAGCGGCAACCAGGAATAGCAACGCAACAAATATGAAAGCTAATT
ATTATATTTAGCTTTCATATTTATATAATATGATGGAAATGGAGGAGGAAAAATGAGTCTTTTGTTAAATATAAAGACAAACTATAACAC
TCCTTGATAATACAACTGGAAATTTTACTTTAGCAAGCATAAAATAGTGGAGGAAAAAAATCCAACTTCAAGCTCTTTGCACTAGTGATG
ATTATGTGATATATCAATGTAATATTTAGCCAGTGGTCATTAGATGTTACTGTGCTTAAACACATCTGATACTCATGCATTGCCTTACAG
GCTAAAAATGTAAGAGGTAGGTGTTCAGTAACCTCAAGTTGGAAAGATATATAATGTTAGAATCCCCTGAGACAAGCCATTTCCCTGAAA
TAGAAATTTACCTCAATACTCATGTAATCTAAGACACTTGGCGTAGTAGCAAAGAAGTTGCCTTCATGTTCTAGTCTCATCTAATTGTGA
CCTTTGTCTTTCATGTACTTCTGAAATCATTTTCCACTTTTTCCACTGGTGTGATTTTGAAACAATTCTGAAATATTTCAGGTAAGATTA
ATAACATCCAATTACAAATATATGTTTCAATATTTTATACGTATGTCTACTTTGAAAGTTAAACCAATAGTATAGAAAGCCTAAGAATGA
ACACTGATTGGACATACTCACAGAAATTAAGGGAAAAACACATATTGTAAAATTCCTGTCAATGTTTGAGTAGAATACAGAAGTACATAG
CAGTCTTCAATTTTTAAACACAATTATGGGCTTATAACTGGACGTGACATGCATCATTTATTAGAACAATATTATTTATTTATACTAAGT
AAGGATATAAGATCACAGAAGCTTAGTGTTATAACGGAGACTTCACAGACATTCATAACTAATGTTTTCTAAGGCAAATAAGGGCATAAA
CCAGAACTCATGGTCAGTGCAGAGTAAGTATAAAAAGTTATGTATGAAAGACATTTATTTATAGAGATTTCTGAGGATTCTATGCCTTTT
CAACTTAAAGATGAGTGTGTCTTAGAATTTGTTTTATGCATCATTGGACTGGGGATGATATTCAAATGTGCACTCAGCGTGTCCTCACAT
TAAAGGGCACATTGAACAGTATAGGAAAATACATCATAAACTAGAATGTTGTACAGATTCATATAACTTTCCCATGTGCTCTGCTGTAGA
GCTGAATTTATATGCCCTTAAAAAGGGATAAGAATCAATTAAATATAAATACGGAAATATACTTATGTTAGGTCACTTAGCTTCAGAGCA
AGATGTCATTAACCTTTATTTCACAGAGAAAAACTGGAAGAAAAGAATGGTGAACAAGAATAAAATGATAAACTTTTTGGCTTATAGAGA
TGTTTCTTGGGAATTTTTTCCACTTGTTTTTATACATGAAAAAAATATCAGTCACAATACAGACATTTCTGTAGTATTTGGTCTGTGGGT
AAACTGGATCCCAGGCAGAATACTTTTTGACACAGGCCTTTTTATACATGCTTTATATATGATGAAGCTTTGGTGAGATGTGACTGCATG
GTAGGATGCATTTTCCTAGGATAGGATATGGTGCTGCTTGTACTTGCCACCTTTTATATGAATGTATGTCGCTACATTGGCCTGTCTTGC
CAAGACATGGTTGAATGAAGCCTGGTGTGAGCTGTCTATTTGAAAAGTCACTAGGATGCATGTTTCATTTGCCGTTACATAATGCCAATT
TGAACCTGTTTCCTCTATATATTAACAATCCAATTGTTAAGATAAAATATACTTTGCTTGAATGAATGATTTTGGTAGTAATATGAGCGT
TATCCTTAAATCAATGTTACAATTTTTGCTATTACTGAAATACCGTCACAGAGGCCACATTATTGGCTGTCTATACCATTGCCTGAGTAA
AATTAGGTTTTTAGGTCTTTTTGGCATTTACTTCTTTTACAGCTGATGTGGAATCAATTATTCCTTTATATGTTCATAAGTACAAAATTT
CACTATCTTAATTACTTCCAAACAAACAATTTCCAAGCAAGGGTATGTGTGCCTGGTTTTTCTGCTCCTCCAATTCTAAGATCGTTATTT
GTTTGCCTTCTGTTTCTCACCCAAAAATACAGATGGTTGGGAAAGATACATCTTATTGAGTTGTCCTATGCAGTCTCTGTCTATATTTGC
ATTTCTTTCTATTCCTATCTTGCCTTTTTTTTTTTTTTTTACACAGATTTGGTTTTCCCTTCCCTTTGTGAAAACCAGAATTGAGCAGCA
TTGTACATCAGAGATGGTACCCAGGAAATGTCTTTGTTCCTCAGTATTTTTCGTCAAAACTTCCATGCAAAGACAGTCCCAGCAAAGTTG
ACATACATCCCAACCTCTCTCATTGGCTTTTCTAACTTTTTATAGAGCTATTCCCCTGAGAAAAGTGAAATGCTGAGTATGATGGGTATT
GCCTGTTGATAGGATAGCTAAGGAAATTTGCTTTTGGAGAATGTATCTTAAATAATTATACAGGAAAGTAGTCACAGTATAGTGTTCTGT
TTAAGGTACATCATGGGTACATAAATGCCTAAAACCTTCATCCTTTGGTCTATTTCTCTGTAAGTGTAAATTACATATATATTAGAAAGA
GAGATAGAATCAAAGAATTAGGGGTGTTACAGAGGCAGCTTTTTGCTGCCTTGGTTTTGACTGTATCAGCATTTCTATTGCAGACCTCTA
TTTTCAGGGGTTTTAGAGACTCGACCATAAAAATTTGTTTCAGGCTTAAAAGTTTTGAAAGATTTTTTTAGGTATCTGATTTTAAACAAA
TAGATCTTGTTTTTATATTATAGGAGGGAAATAAATGGAGTTTACTAGTTCAATTTTGCGCTAATATAACTTTTAATAAACTTAACTTTT
TAAACAAAAACATAAAATCTAATTAGTTCATAGTTGGTTGATGCTTTTTTAAAAGAATCAATTATTGACCTTGAGAAACTTGCCTGCTTC
ATCAGTATAGTAACCTATCTTTAAGATATTTTAAAACGTGTATACCTTTATTAACATTATCTTGATTCCAGCGGTGGATCAGTATGATAA
TGCAGATTTATGACATCCATATAAGCTATCTGGTAATATAGATTTAGGAATATATAGTATATATGATACATATATATATATATATTTACT
AGATAGATTAAGGAGAAAAAGCTCCCATAAACTTAGTTTGTCAAATAAATACCATATATTTAAAAAATGCACAGACATTTATCATTCAGA
GTCAGAATGAGATTCAAGTAATTGCAAAGGGAAGTTGTCTCTTGGGTAAACAATACACATTTTATAGCTTCTTGTGAAACTAATTTTTTC
CTTTCTATATTGTGGTTATGGGAAAGTAAAAGAATTAAAATTAATACAGACTTTATTTAAATAACATTAAACTGTGAAGCAGAGAGAAAC
GCCAGGAAATTAAATATTTAGGCCATTATCTTGTGGTTGTCTGACAATACTTCACCTTTCTTTTAATTCCCCATGATGTTTTCAATTATG
GAGAGAGTATTAAAATCTAGATTTAAGTTTCTGCATTGTTCTCATTACACTCAACACTATTTCATTAAGTTCTTGATAATATGTAGTCTT
CTGTGTGCAAGGAAAGAAATAAATAACACATTTATTTGCTGAATGAGTTTTAAGGTGTGCAAGTTGTAGTGATGTTTTTCCCACACAGGA
TTCTATACACTTATACCATCTTAAATCTGGCATTTTTTTTTTCAGATAGCTTCTACTGACAAACACAAAGCTTGTTTGTGTGCAAATATA
AGGCTAAATAAATGGTGCTAAAGTGTATTATGACTGTCAGATAAAATCAGGCAAAATTTTGTGGTGCTTAAATTAATTTTTTCATTGATT
TTATTGATCAGTGCATTGAACAGTGTTTATTATTCACAAGTTGTCTTTTATTAGTAAATCAAGGCCTCATAGCACATTGTTAAATAAAGT
GGTTGACTAGTCTATGTAACAGCTCACCAAGCTACTATCTCTTTTAACTCCTTATAATGTTGCGTCATTAAAGGTCAAGGGGTCATGCTA
TTAATCTCATTGCTATAGACCATTAACATGACTGAACTTTTCCACAAAGTACTTATGTTTACAATGCTATAACCCTTTGACTGCTGCGGC
AACCTTTAACCACACAAATGTCACAAGCTAGAATCATCAGCATGGTTCTTGCCATGGCAATCAAAGAGTTAAGGGCTGTGCAGTGATTTG
TTTTGTATTTATTAATTTATATTTATTTTGTTTCCATTCAAGGAGGGGATTAGGGGTGGGGCAGTTTTTGTCTGCTGTAAGTGTCTTAAC
CTAGGGAAGGGTTAAATGGCTTTTTATACTATTGCATCTTCTGTATTTACCATCAATTCATTGTGTTGTAATTAAAAGAAACTGTCAATA

>56172_56172_3_MYBL1-MMP16_MYBL1_chr8_67484717_ENST00000524176_MMP16_chr8_89086971_ENST00000286614_length(amino acids)=822AA_BP=576
MAKRSRSEDEDDDLQYADHDYEVPQQKGLKKLWNRVKWTRDEDDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPW
TKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRWAEIAKLLPGRTDNSIKNHW
NSTMRRKVEQEGYLQDGIKSERSSSKLQHKPCAAMDHMQTQNQFYIPVQIPGYQYVSPEGNCIEHVQPTSAFIQQPFIDEDPDKEKKIKE
LEMLLMSAENEVRRKRIPSQPGSFSSWSGSFLMDDNMSNTLNSLDEHTSEFYSMDENQPVSAQQNSPTKFLAVEANAVLSSLQTIPEFAE
TLELIESDPVAWSDVTSFDISDAAASPIKSTPVKLMRIQHNEGAMECQFNVSLVLEGKKNTCNGGNSEAVPLTSPNIAKFSTPPAILRKK
RKMRVGHSPGSELRDGSLNDGGNMALKHTPLKTLPFSPSQFFNTCPGNEQLNIENPSFTSTPICGQKALITTPLHKETTPKDQKENVGFR
TPTIRRSILGTTPRTPTPFKNALAAQEKKYGPLKIVDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFK
DTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGK
EYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRH

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Fusion Gene PPI Analysis for MYBL1-MMP16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MYBL1-MMP16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MYBL1-MMP16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource